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Dissertations / Theses on the topic 'Palladium catalysed synthesis'

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Published: 4 June 2021

Last updated: 7 February 2022

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1

Ostovar, Peyman. "Palladium-catalysed neuroleptic synthesis." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47601.

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2

Sadig, Jessie E. R. "Palladium-catalysed heterocycle synthesis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:c9608957-d215-4a15-87e3-5871c1391946.

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Chapter 1 is a literature review of selected palladium-catalysed aryl C-N and C-S bond forming reactions. The application of these reactions to the synthesis of heterocycles is also discussed. Chapter 2 highlights the importance of the benzimidazole motif and gives a brief discussion of the existing routes to this scaffold. The utility of N-(o-halophenyl)imidoyl chlorides and imidates as precursors to heterocycles is demonstrated in a palladium-catalysed reaction with N-nucleophiles to afford benzimidazole products. Chapter 3 provides a brief introduction to the synthesis of benzothiazoles and

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3

Li, Meiling. "Palladium catalysed allene carbocyclisation." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:747420b6-c11f-451c-83c7-fa9fca5f7752.

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In this thesis, firstly, a Pd-catalysed diastereoselective carbocyclisation of allenes with aryl halides or vinyl iodides was designed and developed to form arylative or vinylative spirolactam compounds. High yields and diastereoselectivities were obtained in the presence of Pd<sub>2</sub>(dba)<sub>3</sub>/dppe and K<sub>2</sub>CO<sub>3</sub> in DMSO at 70 °C, particularly when spiropiperidin-2-ones were formed. The method is simple to perform and broad in scope. Having established the diastereoselective methodology for the arylative or vinylative allene carbocyclisation, a Pd-catalysed en

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4

Damian, Karen Serena. "Pd catalysed synthesis of phosphines for homogeneous catalysis." Thesis, St Andrews, 2009. http://hdl.handle.net/10023/907.

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5

Watson, Emma Louise. "Palladium-catalysed synthesis of 3-aminooxindoles." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531596.

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6

Tadd, Andrew. "Palladium and copper catalysed heterocycle synthesis." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504606.

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7

Ball, Catherine Jane. "Palladium- and copper-catalysed heterocycle synthesis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:589b70fb-0823-4ccf-8b35-1883908f917d.

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A number of privileged starting materials based on aryl halide frameworks have emerged that allow access to a variety of different heterocyclic scaffolds through judicious choice of reaction conditions. This work describes efforts to develop and extend the utility of two of these general heterocycle precursors - ortho-(haloalkenyl)aryl halides A and α-(ortho-haloaryl) ketones B - in conjunction with cascade reactions involving the construction of key carbon-heteroatom bonds via palladium or copper catalysis. Chapter 1 entails an overview of the development of palladium- and copper-catalysed ca

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8

Gatland, Alice Elizabeth. "Palladium-catalysed enolate arylation in the synthesis of isoquinolines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f106760d-2375-4d56-81b2-faa6ee96cabc.

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<strong>Chapter 1. Introduction</strong> Scientific background on the development of homogeneous palladium-catalysed cross coupling reactions, focusing on the α-arylation reaction of enolates and its application to the synthesis of heteroaromatic compounds. The classical syntheses of isoquinolines are discussed, followed by an account of modern methods for their synthesis, including the recent α-arylation-based methodology developed by the Donohoe group. <strong>Chapter 2. Results and Discussion</strong> 2.1 Studies towards the development of a palladium-catalysed, C–H activation-b

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9

Phillips, David J. "Palladium-catalysed synthesis of highly functionalised compounds." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/9011/.

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Palladium-catalysis is extremely important in fine chemical synthesis. This thesis looks at the development of new palladium-catalysed carbon–carbon bond formation reactions, with particular attention to forming new bonds to sp3 carbons. The opening chapter of this thesis gives an overview of current methods for palladium-catalysed heterocyclisation, and the methods for incorporating further functionalisation into this process, then focuses on the optimisation and expansion of a new palladium-catalysed carboallylation reaction. The reaction mechanism was demonstrated via a deuterium-labelling

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10

Yagoubi, Myriam. "Synthesis of heterocycles via palladium-catalysed direct arylation." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e1206b3a-b9e8-4371-a94c-da3bc04c116e.

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Chapter 1 is a brief review on some of the recents developments in palladium-catalysed C-H functionalisation chemistry. The synthesis and functionalisation of heterocycles using these methodologies was particularly emphasised. Chapter 2 presents our efforts to identify a new catalytic system to promote the intramolecular coupling of vinyl bromides with unfunctionalised aryl C-H bonds for the formation of benzofurans. Dihydrobenzofurans were obtained efficiently under mild conditions in the presence of Pd(OAc)₂, X-Phos and K₂CO₃ in DMA at 80 °C and a subsequent one-pot isomerisation under acidi

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11

Marelli, Enrico. "Nickel- and palladium-catalysed deprotonative cross-couplings." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/15603.

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Transition metal-catalysed cross coupling chemistry is a valuable tool for synthetic organic chemistry, enabling the preparation of compounds of great interest. The catalytic metal of choice is usually palladium, which generally offer better performances in term of catalytic activity and easy handling. On the other hand, the use of nickel in this class of reactions is gaining attention, as it would provide more economically and environmentally sustainable processes. Deprotonative cross couplings are a subgroup of these reactions, in which the nucleophile is generated in situ by direct deproton

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12

Pilgrim, Ben Samuel. "Novel palladium-catalysed routes to aromatic heterocycles." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d143b5bf-1738-48ce-be75-4a25249acb9d.

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A brief summary of the use of palladium as a catalyst, the characteristic reactivity of palladium complexes and the commonly used palladium-catalysed cross coupling reactions is given, with a special focus on the palladium-catalysed α-arylation of enolates and its application to the synthesis of aromatic heterocycles. The synthesis of aromatic heterocycles via both traditional methods and more recent metal-catalysed approaches is discussed in the context of isoquinolines. The palladium-catalysed oxidation of dihydrofurans bearing an ortho-bromophenyl group at the 2-position to the correspondin

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13

Smith, Craig. "Palladium-catalysed alkene difunctionalisation in the synthesis of heterocycles." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/8003/.

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The opening chapter of this thesis is split in two with part one providing a summary of the existing methods for palladium-catalysed oxypalladation reactions resulting in the synthesis of oxygen containing heterocycles. Part two focuses on a niche area of palladium catalysis. Here, palladium-catalysed isohypsic reactions, in which the oxidation state of the palladium does not change throughout the entire catalytic cycle, are described and summarised. Chapter 2 describes the extension of the heteroallylation reaction to incorporate the synthesis of lactones and the pursuit of an enantioselectiv

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14

Cordonnier, Marie-Caroline A. "Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:24302e85-de80-4562-a98e-ee0e6ba93862.

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In this work, a new methodology for the synthesis of a number of silylated bicyclic dienes has been reported. These bicyclic dienes allowed access to a variety of enones and phenols in 2 further steps. The stabilities and reactivities of different dialkylisopropoxy silanes have been evaluated,revealing relative instability of the dimethylisopropoxy silyl group towards chromatography. When using the analogous diethylisopropoxy silyl group instead, the products showed greater stability towards chromatography, however a higher temperature was necessary to oxidise the more sterically hindered sily

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15

Durrani, Jamie T. "Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes." Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/6276.

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Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation reactions of alkenes have the potential to deliver valuable chiral carboxylic acid and ester building blocks from cheap feedstocks: alkenes, carbon monoxide and water (alcohols in the case of alkoxycarbonylation). Despite the attractive nature of these reactions, extensive research has so far been unable to produce effective catalysts which are capable of controlling both regio- and enantioselectivity. Building on exciting recent results involving the use of highly enantioselective palladium catalysts derived from Phanephos-type l

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16

Flynn, Bernard L. "The synthesis and palladium-catalysed coupling of 5-Trifluoromethanesulfonyluridine derivatives /." Title page, contents and abstractn only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phf648.pdf.

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17

Lopez, Suarez Laura. "Tetra-substituted olefin synthesis using palladium-catalysed C-H activation." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/5869.

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In an effort to obtain more efficient and greener chemical transformations, a substantial amount of research interest has been directed towards the use of arene C-H bonds as functional groups. Hydroarylation of alkynes through direct functionalisation of C-H bonds has been studied in recent years leading to the development of high-yielding metal-mediated processes. The main aim of the current work is the addition of a third component in the hydroarylation of alkynes trough C-H activation, in order to achieve a second C-C bond formation. Attempts at palladium-catalysed three-component reaction

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18

Sore, Hannah Fiona. "The synthesis and palladium catalysed cross coupling of organosilicon reagents." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608633.

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19

Trejos, Alejandro. "Palladium-Catalysed Couplings in Organic Synthesis : Exploring Catalyst-Presenting Strategies and Medicinal Chemistry Applications." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173068.

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Palladium-catalysed coupling reactions have been embraced by synthetic chemists as one of the preferred means for smooth formation of new carbon-carbon bonds: a truly ubiquitous methodology of synthesizing complex molecules. This thesis describes the study of a series of palladium(0)-catalysed C2-arylations of a 1-cyclopentenyl ether, equipped with a chiral (S)-N-methyl-pyrrolidine auxiliary. The investigated olefin was demonstrated to undergo Si-face insertion, providing (R)-configuration of the arylated C2-carbon. In addition, the mild and novel palladium(II)-catalysed dominoHeck/Suzuki β,α-

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20

Greenaway, Rebecca L. "Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d49aad2d-65ce-4af1-acda-e90921d34a1a.

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The aim of this work was to investigate palladium-catalysed cyclisations of bromoenynamides in the synthesis of amidodienes, which on further reaction or oxidation can lead to a diverse range of heteroaromatic systems. Building upon work within the Anderson group on the palladium-catalysed cyclisations of bromoenynes, we have been able to successfully apply a palladium-catalysed carbopalladation/Stille coupling/electrocyclisation cascade to bromoenynamides and then further develop this to incorporate a Suzuki coupling, leading to bicyclic amidodienes which can undergo selective oxidation to a

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21

Jumnah, Roshan. "Palladium-catalysed allylic amination in the formation of α-amino acids". Thesis, Loughborough University, 1995. https://dspace.lboro.ac.uk/2134/31905.

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The review of this thesis describes palladium catalysed allylic amination in the context of the mechanism and synthetic utility. Examples of alkene geometry, regioselectivity and net retention have been illustrated as a consequence of the amination mechanism. The synthetic aspects of palladium catalysed allylic amination consists of other examples of the formation of enantiomerically enriched allylic amines and amino acids.

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22

Glink, Peter Thomas. "Synthesis of unsaturated [alpha]-amino acid derivatives by palladium catalysed modification /." Title page, contents and absract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phg561.pdf.

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23

Davies, Paul William. "Palladium-catalysed cyclisation-carbonylation cascade processes and their application in synthesis." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268498.

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24

Foltz-Cesar, Carole. "Trisoxazolines: synthesis and application in enantioselective palladium- and copper-catalysed reactions." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-79452.

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25

Henderson, Jaclyn. "Benzyne in synthesis : a search for palladium catalysed three-component couplings." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4868.

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It is over 100 years since scientists first postulated the existence of arynes as reactive intermediates. Their use in organic synthesis is now well-established and investigations into novel methods for their generation and utility in carbon-carbon bond forming reactions continue to this day. In 1983 Kobayashi and co-workers introduced a novel method of generating benzyne under mild conditions, using a fluoride induced decomposition of 2-(trimethylsilyl)phenyl triflate 1. This development has opened the door to employing arynes in a variety of transitionmetal mediated carbon-carbon bond formin

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26

Foltz-César, Carole. "Trisoxazolines : Synthesis and application in enantioselective palladium- and copper-catalysed reactions." Strasbourg 1, 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/FOLTZ-CESAR_Carole_2007.pdf.

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Le but de ce travail a été de concevoir de nouveaux ligands trisoxazolines de haute symétrie et de déterminer leur intérêt par rapport aux ligands de symétrie C2 bien établis dans la littérature. Une étude directe de l’influence de la symétrie C3 en catalyse asymétrique par comparaison directe entre des systèmes trisoxazoline/métal et bisoxazoline/métal a donc été effectuée. Dans un premier temps, trois nouvelles trisoxazolines de symétrie C3 ont été synthétisées avec, sur les cycles oxazoline, les substituants chiraux phenyl, benzyl et indanyl. Des bisoxazolines et trisoxazolines à groupement

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27

Lowe, Martin A. "Development of a palladium-catalysed synthesis of pyrrolidines from vinyl-substituted aziridines." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443678.

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28

Watt, Michael Samuel. "Palladium-catalysed C-H functionalisation in the stereoselective synthesis of complex polyheterocycles." Thesis, University of Bristol, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730843.

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29

Hewitt, Joanne F. M. "Development of methodology for the palladium-catalysed synthesis of oxygen-containing heterocycles." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5096/.

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The opening chapter of this thesis gives an overview of the existing methods to functionalise palladium(II)-alkyl intermediates resulting from oxy- or carbopalladation of unactivated alkenes, outlining the range of heterocycles which can be formed using this type of methodology. A summary of Pd(IV) species in synthesis and catalysis follows, with a focus on Pd(IV) intermediates arising from oxidative addition of alkyl halides to Pd(II) and those suggested in alkene difunctionalisation reactions. As the subsequent formation of sp3–sp3 C–C bonds from Pd(II)-alkyl intermediates was noted as a lim

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30

Hesse, Ronny, Anne Jäger, Arndt W. Schmidt, and Hans-Joachim Knölker. "Palladium(II)-catalysed total synthesis of naturally occurring pyrano[3,2-a]carbazole and pyrano[2,3-b]carbazole alkaloids." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-149135.

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Seven naturally occurring pyranocarbazole alkaloids (pyrayafoline A–E, O-methylmurrayamine A and O-methylmahanine) have been obtained by total synthesis using a palladium(II)-catalysed oxidative cyclisation of a diarylamine to an orthogonally diprotected 2,7-dihydroxycarbazole as key step.

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31

Ainge, Simon W. "A palladium-catalysed carbonylative cyclisation approach to the synthesis of lactams and lactones." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240858.

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32

Esteves, Carlos Henrique Alves. "Palladium-catalysed enolate arylation in the synthesis of aromatic heterocycles and substituted heterocycles." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b69e1a46-3275-4d77-a043-7207e7c93d59.

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<b>Chapter 1. Introduction</b> A literature background on the early development of the Pd-catalysed cross-coupling reactions and the later discovery of the enolate arylation reaction is presented. In the second part, the literature on pyruvate chemistry is explored, focusing on enantioselective transformations and the synthesis of α-arylated pyruvate derivatives. The final part presents reported protocols on the synthesis of β-carboline, isoquinoline and indole esters, from the classical approaches to the more recent methodologies based on metal catalysed transformations. <b>Chapter

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33

Walker, P. Ross. "Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c5c072f8-920a-4894-8223-179fb81db67f.

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The initial aim of this project was to investigate ways of synthesising fused, spirocyclic and linked bicyclic amines. We built on methodology previously developed within our group, employing cyclic dienamides, prepared using the reductive cyclisation of bromoenynamides, as key structural building blocks for further annulation. In the course of investigating the reactivity of these cyclic dienamides, we discovered a new efficient and general route to their synthesis, by employing palladium- or ruthenium-catalysed enynamide cycloisomerisation. A wide range of attractive dienamide scaffolds were

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34

Hodgkinson, Roy. "Synthesis of indoles and azaindoles via copper/palladium catalysed tandem C-N bond coupling." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504479.

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35

Lightowler, Stephen. "Palladium-catalysed cross-coupling reactions in the synthesis of novel organic polymers and monodisperse oligomers." Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342874.

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36

Skillinghaug, Bobo. "Palladium(II)-Catalysed Heck and Addition Reactions : Exploring Decarboxylative and Desulfitative Processes." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304746.

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Palladium complexes have the ability to catalyse cross-coupling of two organic moieties through the formation of transient metal-carbon bonds, thus bringing them closer to each other to facilitate the formation of a new bond. Palladium-catalysed coupling reactions are one of the most important carbon-carbon forming reactions available to organic chemists and many of these reactions rely on the reactivity of aryl-palladium complexes. The investigation of new aryl-palladium precursors is thus of great interest, especially as more sustainable and economic methods can be developed. This thesis des

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37

Hogg, Kirsten Fiona. "Palladium-catalysed carbonylation of aliphatic amines and its application in the total synthesis of cylindricine C." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277806.

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This thesis comprises three projects on the theme of catalytic C(sp3)–H carbonylation of secondary aliphatic amines. Chapter 2 describes the development of a general methyl C–H carbonylation of secondary aliphatic amines to form synthetically useful β-lactam building blocks. Amines exhibiting a range of substitution patterns around the nitrogen functionality, and bearing a wide variety of functional groups, could be tolerated in the reaction. The desired β-lactam products were delivered in high yields, with excellent selectivity observed for the β-C–H position. Computational studies suggested

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38

Åkerbladh, Linda. "Palladium(0)-Catalysed Carbonylative Multicomponent Reactions : Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329970.

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Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. By varying the components of the carbonylative multicomponent reaction, considerable product diversity can readily be attained. However, due to the reluctance to use toxic CO gas, considerable efforts have been directed at exploring non-gaseous approaches. The work described in this thesis has mainly focused on the develo

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39

Owens, Thomas Graham. "The promoting role of Au in the Pd-catalysed synthesis of vinyl acetate monomer." Thesis, University of St Andrews, 2007. http://hdl.handle.net/10023/352.

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40

Ho, Danny Ka Hei. "Palladium(II)-catalysed sp 3 C–H functionalisation of hindered amines and its application in synthesis of astemizole analogues." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/267480.

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The development of a palladium-catalysed C–H carbonylation of hindered secondary amines is described. Central to this strategy is the temporary conversion of simple ketones into hindered secondary amines that facilitates a sterically promoted palladium-catalysed C–H activation. A range of functional groups are shown to be compatible with this catalytic process, and with exclusive regioselectivity for the terminal ethyl sp 3 C–H in most cases. This method allows an overall incorporation of a carboxyl group to the b-position of terminal ketones, generating 1,4- dicarbonyl moieties which are impo

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41

Thomas, Claudia, Olga Kataeva, Arndt W. Schmidt, and Hans-Joachim Knölker. "Regioselective prenylation of bromocarbazoles by palladium(0)-catalysed cross coupling – synthesis of O-methylsiamenol, O-methylmicromeline and carquinostatin A." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36279.

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We describe the regioselective prenylation of 3-bromocarbazole by palladium(0)-catalysed cross coupling with a prenylstannane or a prenylboronate. The procedure is applied to the synthesis of precursors for biologically active carbazole alkaloids.

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42

Milton, Edward J. "Pd catalysed C-C & C-O bond formation using bis-(dialkyl/diarylphosphino)ferrocene ligands." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1022.

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A brief introduction explaining phosphine ligand properties, Pd catalysed cross-coupling reactions; the importance of the steps involved in the catalytic cycle (oxidative addition, transmetalation & reductive elimination), mechanistic studies and a comparison of various reactions will give an overview of important cross-coupling reactions and their limitations. The development of a “super-concentrated” (5M) Pd catalysed Kumada type coupling reaction has been developed for coupling a range of aryl bromide and chloride substrates with the Grignard reagents ((p-CF₃-C₆H₄)MgBr)) and PhMgBr in methy

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43

Haire, Andrew Richard. "Probing the influence of bimetallic composition on the Pd/Au catalysed synthesis of vinyl acetate monomer." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1018.

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Scanning Tunnelling Microscopy (STM) was utilised together with the high resolution depth-profiling capabilities of Medium Energy Ion Scattering (MEIS), a technique traditionally associated with single crystal substrates, to probe the mean size and depth dependent composition profile of bimetallic PdAu nanoparticles on planar oxide surfaces as functions of the starting composition and annealing temperature. In order to fit composition profiles to experimental MEIS data, a new analysis tool has been designed that models the particles as flat-topped structures with a hexagonal base which can be

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44

Krahl, Micha P. "Regioselektive Synthese oxygenierter Carbazole." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1168004377329-87485.

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In der heutigen Wirkstoffforschung stellen vor allem multiresistente Krankheitserreger eine große Herausforderung an die Wissenschaft dar. Noch sterben z.B. an der Tuberkulose jährlich etwa 1.7 Millionen Menschen, davon 69000 allein in Europa (WHO-Angaben, 2004). Die Tuberkulose verursacht neben AIDS die meisten Todesfälle unter den Infektionskrankheiten. Ein großes Problem sind die zahlreichen Neuerkrankungen, die mit herkömmlichen Mitteln nicht mehr behandelt werden können, sowie zunehmende Medikamentenallergien. Somit ist ein wichtiges Gebiet der Wirkstoff-forschung, neben der Weiterentwick

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45

Krahl, Micha P. "Regioselektive Synthese oxygenierter Carbazole." Doctoral thesis, Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A24953.

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In der heutigen Wirkstoffforschung stellen vor allem multiresistente Krankheitserreger eine große Herausforderung an die Wissenschaft dar. Noch sterben z.B. an der Tuberkulose jährlich etwa 1.7 Millionen Menschen, davon 69000 allein in Europa (WHO-Angaben, 2004). Die Tuberkulose verursacht neben AIDS die meisten Todesfälle unter den Infektionskrankheiten. Ein großes Problem sind die zahlreichen Neuerkrankungen, die mit herkömmlichen Mitteln nicht mehr behandelt werden können, sowie zunehmende Medikamentenallergien. Somit ist ein wichtiges Gebiet der Wirkstoff-forschung, neben der Weiterentwick

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46

Marchbank, John David. "Palladium-catalysed cascade ring syntheses." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405708.

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Sebelius, Sara. "Palladium-Catalyzed Synthesis and Transformation of Organoboranes." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1198.

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Rozhkov, Roman Vladimirovich. "Synthesis of Dihydrobenzofurans via Palladium-Catalyzed Heteroannulations." Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/835297-tuwp7H/webviewable/.

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Harris, Michele C. 1975. "The palladium-catalyzed synthesis of organic amines." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/29226.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.<br>Vita.<br>Includes bibliographical references.<br>Chapter 1. The chelating ligand bis[2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or electron-rich aryl bromides. In addition

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Durbin, Matthew J. "Palladium catalysis for natural product synthesis." Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519010.

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This thesis details investigations towards the total synthesis of the naturally occurring alkaloid hodgkinsine, utilising palladium catalysis to achieve desymmetrisation of a meso-chimonanthine derivative. Initially, a Suzuki cross-coupling approach was envisaged. Meso-chimonanthine is functionalised as its C-7 bisiodide derivative by directed ortho-lithiation. Suitable electrophiles are screened for the successful preparation of additional bisbromide and bistriflate derivatives to broaden the scope of the cross-coupling. The synthesis of a suitable indole-3-boronic ester coupling partner is a

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