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Dissertations / Theses on the topic 'Palladium-catalyzed arylation'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Sävmarker, Jonas. "Palladium-Catalyzed Carbonylation and Arylation Reactions." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167720.

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Palladium-catalyzed reactions have found widespread use in contemporary organic chemistry due to their impressive range of functional group tolerance and high chemo- and regioselectivity. The pioneering contributions to the development of the Pd-catalyzed C-C bond forming cross-coupling reaction were rewarded with the Nobel Prize in Chemistry in 2010. Today, this is a rapidly growing field, and the development of novel methods, as well as the theoretical understanding of the various processes involved are of immense importance for continued progress in this field. The aim of the work presented

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2

Niwa, Takashi. "Studies on Palladium-Catalyzed Benzylic Arylation." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/77959.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第14583号<br>工博第3051号<br>新制||工||1454(附属図書館)<br>26935<br>UT51-2009-D295<br>京都大学大学院工学研究科材料化学専攻<br>(主査)教授大嶌幸一郎, 教授檜山爲次郎, 教授松原誠二郎<br>学位規則第4条第1項該当

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3

Lafrance, Marc. "Development of new palladium-catalyzed arylation reactions." E-theses uOttawa (Restricted to University of Ottawa), 2008. https://login.proxy.bib.uottawa.ca/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:NR41635.

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4

Fujino, Daishi. "Studies on Palladium-Catalyzed Arylative Cyclization Reactions." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188508.

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5

Duvall, Bridget Rebecca. "Efforts toward (+)-7-deoxypancratistatin featuring a palladium catalyzed allylic arylation." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2336.

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Thesis (M.S.)--University of Maryland, College Park, 2005.<br>Thesis research directed by: Dept. of Chemistry and Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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6

Mo, Jun. "Palladium catalyzed heck arylation of electron-rich olefins by aryl halides." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433729.

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7

Rousseaux, Sophie. "Palladium-Catalyzed C(sp2)-C(sp3) Bond Formation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23058.

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Palladium-catalyzed reactions for carbon-carbon bond formation have had a significant impact on the field of organic chemistry in recent decades. Illustrative is the 2010 Nobel Prize, awarded for “palladium-catalyzed cross couplings in organic synthesis”, and the numerous applications of these transformations in industrial settings. This thesis describes recent developments in C(sp2)-C(sp3) bond formation, focusing on alkane arylation reactions and arylative dearomatization transformations. In the first part, our contributions to the development of intramolecular C(sp3)-H arylation reactions

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8

Beydoun, Kassem. "Palladium catalyzed direct arylation of heteroaromatics via C-H bond activation : a green access to fine chemicals and materials." Rennes 1, 2012. http://www.theses.fr/2012REN1S174.

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During this thesis, we were interested in the C-H bonds activation catalyzed by palladium catalysts such PdCl(C₃H₅)(dppb) and ligand-free or ligand associated Pd(OAc)₂ for the préparation of biaryls. This method is considered as cost effective and environmentally attractive compared to other types of couplings such as Suzuki, Stille, or Negishi. First we demonstrated that it is possible to apply C-H bond activation method for the direct arylation of formyl or acetyl halothiophene derivatives. The corresponding products could be further functionalized due to the presence of the halo and carbony

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9

Jiang, Tuo. "Palladium(II)-Catalyzed Oxidative Carbocyclization : Stereoselective Formation of C–C and C–B Bonds." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-108669.

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Transition metal catalysis has emerged as one of the most versatile methods for the selective formation of carbon–carbon and carbon–heteroatom bonds. In particular, oxidative carbon–carbon bond forming reactions have been widely studied due to their atom economic feature. This thesis has been focused on the development of new palladium(II)-catalyzed carbocyclization reactions under oxidative conditions. The first part of the thesis describes the palladium(II)-catalyzed oxidative carbocyclization-borylation and -arylation of enallenes. In these reactions, the (σ-alkyl)palladium(II) intermediate

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10

Persson, Andreas K. Å. "Palladium(II)-Catalyzed Oxidative Cyclization Strategies : Selective Formation of New C-C and C-N Bonds." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-75435.

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The main focus of this thesis has been directed towards preparation and oxidative carbocyclization of en-, dien- and aza-enallenes. In the first part of this thesis, a stereoselective oxidative carbocyclization of dienallenes was realized. By employing cheap and readily available palladium trifluoroacetate we were able to efficiently cyclize a variety of dienallenes into hydroxylated carbocycles in high yield and high selectivity. This oxidative process was compatible with two different reoxidation protocols: one relying on p-benzoquinone (BQ) as the oxidant and the other employing molecular o

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11

Zhao, Liqin. "Palladium-catalyzed direct arylation via sp² and sp³ C-H activation of hetero(aromatics) and hydrocarbons for C-C bond formation." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S038/document.

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Au cours de cette thèse, nous nous sommes intéressés à l'activation de liaisons sp² et sp³ C-H catalysée par le palladium pour la préparation d'(hétéro)aryl-aryles et de biaryles. Cette méthode est considérée comme attractive pour l'environnement par rapport aux méthodes classiques, tels que Suzuki, Heck, ou Negishi. Tout d'abord, nous avons décrit que la C2-arylation directe de benzothiophènes peut être effectuée par un catalyseur du palladium en l'absence de ligand phosphine avec une grande sélectivité. Nous avons également démontré qu'il est possible d'activer les positions C2 et C5 de pyrr

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12

Liang, Yong. "Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1591.

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The antiviral or anticancer activities of C-5 modified pyrimidine nucleoside analogues validate the need for the development of their syntheses. In the first half of this dissertation, I explore the Pd-catalyzed cross-coupling reaction of allylphenylgermanes with aryl halides in the presence of SbF5/TBAF to give various biaryls by transferring multiple phenyl groups, which has also been applied to the 5-halo pyrimidine nucleosides for the synthesis of 5-aryl derivatives. To avoid the use of organometallic reagents, I developed Pd-catalyzed direct arylation of 5-halo pyrimidine nucleosides. It

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13

Naas, Mohammed. "Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2009/document.

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L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles. Dans la première partie, nous avons étudié la sélectivité des couplages de type Suzuki, pour fonctionnaliser la position 3 d’indazoles possédant la fonction NH libre. Par la suite, un nouveau procédé d’(hétéro)arylation direct pallado-catalysé régiosélectif a été mis à profit pour synthétiser des indazoles fonctionnalisés tant sur la position 3 que sur le som

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14

Bassoude, Ibtissam. "Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00789954.

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Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l'accès de façon rapide et efficace à différents dérivés pyrazolo[1,5-a]pyrimidiniques diversement fonctionnalisés.La première partie de ce travail concerne l'étude et l'application de la condensation de la pyran-2-one avec les 5(3)-amino-3(5)-arylpyrazoles que ce soit par chauffage classique ou sous irradiation micro-onde. Par la suite, un nouveau procédé d'(hétéro)arylation pallado-catalysé direct régiosélectif a été mis à profit pour élaborer des pyrazolo[1,5-a]pyrimidines fonctionnalisées tant en

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15

Zucker, Sina Patricia [Verfasser]. "Investigation of Structure-Reactivity Relationships of Arylpalladium Complexes in Transmetalations with Arylzinc Reagents : and Palladium-Catalyzed Directed Halogenations of Bipyridine N-Oxides, and Mechanistic Investigations of the Direct Arylation of Pyridine N-Oxides with Bromoarenes / Sina Patricia Zucker." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1124465286/34.

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16

Tomakinian, Terry. "Nouvelles méthodes de synthèse de benzofuroindolines. Vers la synthèse de la phalarine." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS031.

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Les benzofuroindolines forment une famille de composés qui se retrouvent sous deux formes : les benzofuro[2,3-b]indolines ou les benzofuro[3,2-b]indolines. Ce motif se retrouve dans de nombreuses molécules naturelles comme la bipleiophylline, la voacalgine A, le diazonamide A et la phalarine ce qui a mené à de nombreuses recherches pour leur synthèse. La biogénèse postulée est le couplage oxydant d'un indole et d'un phénol. Nous avons développé plusieurs voies d'accès à ces motifs en utilisant le noyau indolique. La première étude a consisté en un couplage oxydant direct entre un N-acétylindol

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17

Tanji, Yutaka. "Steric Effect of Carboxylate Ligands on Pd-Catalyzed C-H Bond Arylation Reactions." Kyoto University, 2020. http://hdl.handle.net/2433/253293.

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18

Petrov, Ivan. "The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19788.

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The regioselectivity in Pd(0)-catalyzed direct arylation of pyrrole, thiophene, and indole can be improved by blocking some of the reactive sites with a chloride group, leading to increased yields of the desired regioisomers. Competition experiments and computational studies show that the blocking group also activates the substrates toward arylation. Due to the activated nature of chlorinated heteroaromatics, rare and sought after regioisomers, such as 3-arylthiophenes, can be obtained under mild conditions in good yields. Chlorine-bearing thiophenes arylated at C3 and C4 have the potential

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19

Schipper, Derek. "Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20121.

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Part 1: Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis. These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates. Of these processes, direct arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry. Also, alkyne hydroarylation has garnered interest because it allows for the atom-economical synthesis of functionalized alkenes directly from si

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20

Li, Haoran. "Pd-catalyzed C-H bond functionalizations of (hetero)arenes and alkenes : A one step access to poly(hetero)aromatics and styrene derivatives." Thesis, Rennes, Ecole nationale supérieure de chimie, 2020. http://www.theses.fr/2020ENCR0068.

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Afin d'expliquer le contexte de mon travail de recherche, j'ai résumé dans le premier chapitre des informations mécanistiques générales sur l'arylation des liaisons C-H catalysée par le palladium et j'ai détaillé certains travaux sur l'arylation directe en relation avec mes travaux. Mes objectifs étaient d'étudier la réactivité de nouvelles unités synthétiques permettant l'accès direct à des composés bi-(hétéro)aryls ou à des dérivés du styrène. Ensuite, dans les chapitres 2 à 6, j'ai résumé mes travaux de recherche. J'ai étudié l’arylation directes en C2 du Methoxsalen par des chlorures de be

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21

Zhang, Yin. "Backbone decoration of imidazol-2-ylidene ligands with amino groups and their application in palladium catalyzed arylative amination reaction." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30109/document.

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Ce travail s'inscrit dans le cadre de la chimie des carbènes N-hétérocycliques (NHC) et s'articule autour de la fonctionnalisation directe de l'hétérocycle des l'imidazol-2-ylidènes par substitution formelle d'un ou deux groupements diméthylamino. Deux nouvelles catégories de NHCs ont d'abord été obtenues par cette stratégie, dénommées 4-(diméthylamino)imidazol-2-ylidène IArNMe2 et 4,5-bis(diméthylamino)imidazol-2-ylidène IAr(NMe2)2. Les sels d'imidazolium précurseurs de ces NHCs, à savoir le triflate de 4-(diméthylamino)imidazolium (IArNMe2)·HOTf et le triflate de 4,5-bis(diméthylamino)imidaz

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22

Zine, Khalid. "Synthèse régio- et stéréosélective du 4,4,4-trifluorobut-2-énoate d'éthyle porteur d'un groupement tributylstannyl en position alpha ou bêta : réactivité cupro-catalysée des vinylétains en l'absence de complexes du palladium." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR4044/document.

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Vu l’importance des molécules fluorées dans différents domaines et vu la réactivité engendrée par le 4,4,4-trifluorobut-2-ynoate d’éthyle 1 lors des travaux antérieurs réalisés au laboratoire, nous avons décidé d’étudier le comportement de dérivé fluoré 1 vis-à-vis d’hydrure tributylétain sans l’emploi de catalyseurs ou d’additifs. Le but est d’accéder à de nouveaux synthons fluorés par voies originales.Après une étude préliminaire pour effectuer cette réaction d’hydrostannation dans les meilleures conditions, nous avons réalisé pour la première fois la synthèse totalement régio- et stéréoséle

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23

Lin, Yu-Jen, and 林囿任. "Aqueous Palladium-Catalyzed Direct-Arylation Polymerization." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/cx8t87.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>107<br>Direct arylation polymerization (DArP) has been developed to synthesize conjugated polymers. Compared to the conventional cross-coupling methods, DArP exhibits atomic economy and reduces the synthetic cost. On the other hand, with the decent optoelectronic characteristics and outstanding water solubility, water-soluble conjugated polymers are widely used in biomedical science, especially in biosensor or cell imaging. However, most of the reactions were achieved by traditional cross-coupling methods. Also, the environmental media are usually organic solven

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24

Chang, Yu-Hsuan, та 張宇瑄. "Palladium-Catalyzed α-Arylation of Indoxyls". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/xwqj7x.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>108<br>This research mainly describes the optimization process and results of palladium-catalyzed α-arylation of indoxyl species. Indoxyl species was prepared by using commercially available indole-3-carboxaldehyde as a starting material. Then we used a base to promote the alkylation of indoxyl. A series of different alkyl substituted indoxyl compounds were successfully synthesized. In the palladium-catalyzed α-arylation of α-alkylindoxyl, we tested different combinations of bases, ligands, palladium sources and solvents. After many experiments, we found that the

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25

Yi-KuanLin and 林宜冠. "Palladium-Catalyzed Intramolecular Arylation of Benzylic Carbon-Hydrogen Bond:Synthesis of Methylene-Bridge polyarenes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/04072741003720431427.

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碩士<br>國立成功大學<br>化學系碩博士班<br>98<br>Several fluorene derivatives 8 have been generated by the Pd-catalyzed through the benzylic C-H bond activation, cyclization of biphenyls 10. Based on this synthetic method, five fluorene derivatives have been prepared in 81-88 %. And applied this method for prepared indenofluorene in high yield. This procedure provides not only single regioselectivity and compatibility but also excellent yield. Systematic studies of the reaction conditions revealed that palladium catalysts, base and solvents all play key roles. The reaction conditions have been optimized. Upon

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26

Yang, Yi-Chi, and 楊逸祺. "Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/d5uge4.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>108<br>A set of cascade deprotonative arylation processes of cyclic vinylogous esters has been developed. These transformations were notably empowered by a catalytic reaction system entailing palladium diacetate and sterically bulky phosphine ligands, tris(1-adamantyl)phosphine (PAd3). A range of multiply arylated structures bearing bisbenzylic α-quaternary carbon center was synthesized in good yields. Notably, we discovered that the kinetic barrier of the first arylation reaction is significantly lower. Taking advantage of this phenomenon, a sequential introductio

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27

Jheng-JhihChen and 陳政志. "Palladium-Catalyzed Arylation of Methylene-Bridged Polyarenes: Synthesis and Structures of 9-Arylfluorene Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/94329607511854507448.

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碩士<br>國立成功大學<br>化學系碩博士班<br>100<br>The main goal of this paper is to develop a new synthetic method for the preparation of 9-arylfluorene (10), which is applicable to OLEDs and chiral catalysts. In the presence of a catalytic system comprised of palladium(II) acetate and tris(cyclohexyl)phosphonium tetrafluoroborate, the reaction of fluorene (2) with haloarenes (25) generated 9-arylfluorenes (10) in good to excellent yields. The scope and limitations of the coupling reaction were investigated. A wide range of functional groups, including alkyl, alkoxy, ester, ketone and nitrile can tolerate the

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28

Chen, Cheng-Yi, and 陳政毅. "Efficient Microwave-Assisted Palladium-Catalyzed Selective N-Arylation of Anilines with 2,3-Dihalopyridines in Water." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/47722773190002375151.

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碩士<br>高雄醫學大學<br>藥學研究所<br>101<br>A principal goal of organometallic chemistry was the catalytic synthesis of organic compounds by using the transition metals with organic ligands. The palladium-catalyzed arylation of N-nucleophiles was an established and efficient method, which has been widely applied to organic chemistry. Organic reaction in water have recently attracted much attention, only because of its unique reactivity was often observed in water but also because water was a safe and more economic solvent for conventional organic reaction. Thus, the development of environmental safe,

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29

Schulman, Jacqueline Madeleine. "Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles." Thesis, 2011. http://hdl.handle.net/1807/31434.

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Increasing attention has recently been directed toward 1,2,3-triazole-containing compounds. With their unique properties and excellent stability, 1,4-disubstituted triazoles are readily accessible via the copper catalyzed azide alkyne cycloaddition (CuAAC). As compounds containing fused triazoles become common in pharmaceutical targets and biologically active substances, new strategies to synthesize this class of molecules are highly desirable. An efficient and highly modular approach toward the synthesis of three different heterocyclic motifs containing fused 1,2,3-triazoles is reported.

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30

Hou, Wen-Yi, та 侯文易. "Palladium-Catalyzed α Arylation Reaction of Cyclic Vinylogous Esters: Total Syntheses of Aromatic Podocarpane-type Diterpenoids". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/99977t.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>105<br>The first part of this thesis describes palladium-catalyzed α-arylation reaction of cyclic vinylogous esters. The commercial 1,3-cyclohexedione (81) was undergo three times alkylation on the different atoms of compound 81 to get the vinylogous esters 86. We examined several reaction parameters and found the optimal condition called for the combination of Pd(dba)2 and tBuP3 and lithium dicyclohexylamide acting as a base. The optimized conditions were utilized to conduct the coupling reaction between a vinylogous ester and bromoarenes. Electron-deficient and E

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Hsu, Chien-ming, and 徐堅銘. "Bipyridine and Pyrazine Derivatives as Ligands for Palladium-Catalyzed Heck and Heck-Type Arylation of Olefins." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/386vm7.

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32

Tsai, Shiang-Lin, and 蔡香琳. "Palladium(II)-Catalyzed Ortho Arylation of 2-Phenylpyridines and 2-(phenylthio)pyridines with Potassium Aryltrifluoroborates via C-H Functionalization." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/89749928632719697247.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>97<br>An efficient one-pot synthesis of ortho arylated 2-phenylpyridine and pyridine derivatives with potassium aryltrifluoroborates is presented. The optimal reaction conditions are as follows: 2-phenylpyridine and pyridine derivatives were treated with two and a half equivalents of potassium aryltrifluoroborates in the presence of 10 mol % Pd(OAc)2, three equivalents of Cu(OAc)2, two equivalents of p-benzoquinone in 1,4-dioxane at 120 oC for 24 h. p-Benzoquinone is an essential co-oxidant and promoter in the transmetallation-reductive elimination step. The kin

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33

Geary, Laina Michelle. "A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene." 2011. http://hdl.handle.net/1993/4381.

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Trichloroethylene, a simple and very inexpensive material, has been identified as a tri- and tetrafunctionalizable building block. A combination of selective palladium-catalyzed cross-coupling reactions with standard lithiation and electrophilic quenching yields a wide variety of unsaturated linear or cyclic compounds in excellent yields in few synthetic steps. Dichlorovinyl ethers, obtained from a nucleophilic displacement reaction with trichloroethylene, are the basic starting materials. Two sets of conditions have been developed to achieve the reaction of either electron-rich or –defici

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34

Wu, Chung-chiu, and 吳仲丘. "Palladium (II)-Catalyzed Ortho Arylation of 9-(Pyridin-2-yl)-9H-carbazoles via C-H Bond Activation And Mechanistic Investigation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/17866903721550186564.

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碩士<br>國立中山大學<br>化學系研究所<br>100<br>A one-pot synthesis of ortho-arylated 9-(pyridin-2-yl)-9H-carbazoles via C-H bond activation, in which palladium(II)-catalyzed cross-coupling of 9-(pyridin-2-yl)-9H-carbazoles with potassium aryltrifluoroborates is presented. Silver nitrate and tert-butanol were proved to be the best oxidant and solvent for the process, respectively. The product yields fluctuated from modest to excellent, and the reaction showed sufficient functional group tolerance. p-Benzoquinone served as an important ligand for the transmetalation and reductive elimination steps in the cata

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35

Li, Chin-Wei, and 李晉緯. "Palladium(II)-Catalyzed Selective Aroylation of N-Arylpyridin-2-amines and Arylation of Pyrazolo[1,5 a]pyridines via C-H Activation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/30340383722807719251.

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碩士<br>國立中山大學<br>化學系研究所<br>104<br>Part I A direct ortho-aroylation of N-arylpyridin-2-amines with aldehydes to afford mono- and di-aroylated N-arylpyridin-2-amines in modest to good yields is presented. In the reaction, palladium(II) acetate, tert-butyl hydroperoxide (TBHP), and 1,4-dioxane were used as the catalyst, oxidant, and solvent, respectively. The synthetic methodology serves good functional group compatibility (Scheme a). A plausible mechanism of the catalytic C-H aroylation was suggested with the intermolecular and intramolecular experiments in Kinetic Isotope Effect and experiment

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Ladd, Carolyn L. "Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs." Thèse, 2017. http://hdl.handle.net/1866/20442.

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Huang, Hao-ping, and 黃皓平. "Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/33597258074376514286.

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碩士<br>國立中山大學<br>化學系研究所<br>101<br>The direct ortho arylation of 4-methyl-N-phenylpyridin-2-amines via palladium(II)-catalyzed C-H activation is described. Treatment of 4-methyl-N-phenylpyridin-2-amine with potassium aryltrifluoroborate using ten mol % of Pd(OAc)2 as the catalyst, two equivalents of copper (II) acetate as the oxidant and one equivalent of p-benzoquinone in tert-butyl alcohol gave the ortho-arylated products in modest to excellent yields. This reaction shows good functional group compatibility. A series of controlled experiments and 1H NMR titration experiments for the reaction w

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Poupart, Julien. "Synthesis, diversification and biomedical applications of 4,5-substitued N-aminoimidazol-2-ones." Thesis, 2020. http://hdl.handle.net/1866/24770.

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In peptide-based medicinal chemistry, mimicry of turn conformations is important because of the significance of such secondary structures for molecular recognition. In this context, N-aminoimidazol-2-one (Nai) residues have demonstrated ability to mimic the central residue of turn conformers. Moreover, potential to functionalize the 4- and 5-positions of the Nai heterocycle offer opportunities to add and orient side chain functionalities with constrained c-geometry. Methods have been developed to employ Nai residues for peptide mimicry. Previously, Nai dipeptide esters with substituents at

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Blignaut, Jacques Philip. "Theoretical aspects of palladium-catalyzed direct arylations of heterocycles." Thesis, 2017. https://hdl.handle.net/10539/24983.

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Thesis (M.Sc.)--University of the Witwatersrand, Faculty of Science, School of Chemistry, 2017.<br>In this work, commercially relevant palladium catalysed direct arylation reactions, in which the molecule oxazole is coupled to toluene were investigated computationally. These involve the Pd(II)/Pd(0) manifold. Each of the three hydrogen atoms of oxazole can be replaced by a toluene molecule, and as both mono- and di-substitution occurs there are 6 possible products. Experimental results, using the catalyst Pd(OAc)2 in DMA solvent, show that both the presence and quantity of tri-tertiary bu

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Chen, Yi-An, and 陳怡安. "Palladium-Catalyzed Arylative Ring Opening of Meyers’ Lactam Foraml Synthetic of Schulzeine C: Optimization of Aza-annulation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/56r445.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>108<br>(I) project 1: Quaternary carbon stereocenter is an important trait in natural products. Meyers’ lactam is a useful template to construct a quaternary carbon stereocenter. In previous works, quaternary carbon stereocenter was settled by sequential alkylation. Herein, we focused on palladium-catalyzed -arylation of bicyclic lactam to furnish a stereocenter with aryl group. In this chapter, we also describe a new reactivity to generate heterocyclic ring product through hydride shift. After extensive screening of the condition, we found that reaction conversio

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