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Journal articles on the topic 'Palmoplantar keratoderma'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Dessureault, Josee, Yves Poulin, Marc Bourcier, and Eric Gagne. "Olmsted Syndrome—Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma." Journal of Cutaneous Medicine and Surgery 7, no. 3 (2003): 236–42. http://dx.doi.org/10.1177/120347540300700309.

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Background: Olmsted syndrome is a rare congenital disorder with mutilating palmoplantar keratoderma, periorificial keratotic plaques, and other variable features. Objective: We describe a 65-year-old woman with Olmsted syndrome complicated by the occurrence of a malignant melanoma inside the plantar keratoderma. To our knowledge, this is the first reported case of such an occurrence in Olmsted syndrome. The published cases of this rare disorder are reviewed. Conclusion: An association between malignant epithelial tumors and Olmsted syndrome has already been reported. The association of maligna

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2

Bhansali, Ashok, Setu Mathur, Gunjan Bhansali, and Anuroopa Kishan. "Palmoplantar Keratoderma with Periodontitis." Journal of Health Sciences & Research 8, no. 2 (2017): 89–92. http://dx.doi.org/10.5005/jp-journals-10042-1057.

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ABSTRACT Palmoplantar keratodermas (PPKs) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. The PPKs are distinguished by their mode of inheritance and by the presence of certain associated clinical features. Periodontitis was reported in association with more than one syndrome characterized by PPK. Knowledge about heterogeneous groups of acquired or hereditary PPK is important, leading to an appropriate diagnosis and corrective therapies in the future. This case report aims at critically reviewing the literature concerned with PPK an

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3

OʼConnor, Elizabeth A., and William W. Dzwierzynski. "Palmoplantar Keratoderma." Annals of Plastic Surgery 67, no. 4 (2011): 439–41. http://dx.doi.org/10.1097/sap.0b013e3182085a8b.

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4

Lestre, Sara, Eva Lozano, Cláudia Meireles, and Ana Barata Feio. "Autoimmune Thyroiditis Presenting as Palmoplantar Keratoderma." Case Reports in Medicine 2010 (2010): 1–3. http://dx.doi.org/10.1155/2010/604890.

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Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics and corticosteroids. Her past medical and family histories were unremarkable. She complained of recent asthenia, mood changes and constipation. Laboratory evaluation revealed an autoimmune thyroiditis with

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5

Shchagina, Olga, Valeriy Fedotov, Tatiana Markova, et al. "Palmoplantar Keratoderma: A Molecular Genetic Analysis of Family Cases." International Journal of Molecular Sciences 23, no. 17 (2022): 9576. http://dx.doi.org/10.3390/ijms23179576.

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Palmoplantar keratoderma is a clinically polymorphic disorder with a heterogeneous etiology characterized by marked hyperkeratotic lesions on the surface of palms and soles. Hereditary forms of palmoplantar keratoderma usually have autosomal dominant inheritance and are caused by mutations in dozens of genes, most of which belong to the keratin family. We carried out clinical and molecular genetic analysis of the affected and healthy members of four families with autosomal dominant palmoplantar keratoderma. In three out of four family cases of autosomal dominant palmoplantar keratoderma, the f

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6

Ortonne, JP, L. Juhlin, P. El Baze, and G. Pautrat. "Familial rolled and spiral hairs with palmoplantar keratoderma." Acta Dermato-Venereologica 65, no. 3 (1985): 250–54. http://dx.doi.org/10.2340/0001555565250254.

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A 59-year-old man with palmoplantar keratoderma and rolled spiral hairs on the abdomen and extremities is reported. His father had the same skin manifestations but his brother and sister only keratoderma palmoplantare. Scanning electron microscopy of the rolled hairs showed that they were coiled in a spiral around their own axis. These spiral hairs had lower cysteine than the normal appearing hairs on the body. The scalp hair appeared normal but was low in cysteine which was compensated by an increase in threonine. Urine analysis showed a decrease of cysteine.

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7

SS, Vishal Anand, Rakshith UR, and Srikanth MS. "A Review on Palmoplantar keratodermas." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 6 (2022): 6258–31. http://dx.doi.org/10.37285/ijpsn.2022.15.6.8.

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A palmoplantar keratoderma is a group of hereditary, keratinization disorders characterised by hyperkeratotic thickening of the palms and soles. PPK presents in three forms namely diffuse, focal & punctate. The aetiological factors of Palmoplantar keratoderma are drug-related, chemical-related, systemic disease-related, infection-related, & idiopathic. Palmoplantar keratodermas are diagnosed based on their clinical manifestations and forms. Tiny raindrop-shaped lesions, which are relatively uncommon in nature are one of the clinical symptoms of Type-I PPK. The papules are round and hyp

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8

USUKI, Kazunari. "Aquagenic Palmoplantar Keratoderma." Nishi Nihon Hifuka 65, no. 5 (2003): 443–45. http://dx.doi.org/10.2336/nishinihonhifu.65.443.

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9

Yan, Albert C., Sumaira Z. Aasi, William J. Alms, et al. "Aquagenic palmoplantar keratoderma." Journal of the American Academy of Dermatology 44, no. 4 (2001): 696–99. http://dx.doi.org/10.1067/mjd.2001.113479.

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10

Patel, Shaily, Matthew Zirwas, and Joseph C. English. "Acquired Palmoplantar Keratoderma." American Journal of Clinical Dermatology 8, no. 1 (2007): 1–11. http://dx.doi.org/10.2165/00128071-200708010-00001.

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11

KAWAI, Kazuhiro, Tomoko FUKUSHIGE, Masanao SAKANOUE, and Takuro KANEKURA. "Striate palmoplantar keratoderma." Journal of Dermatology 37, no. 9 (2010): 854–56. http://dx.doi.org/10.1111/j.1346-8138.2010.00874.x.

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12

Imbernón-Moya, A., A. Aguilar-Martínez, and E. Vargas-Laguna. "Linear Palmoplantar Keratoderma." Actas Dermo-Sifiliográficas (English Edition) 109, no. 3 (2018): 269. http://dx.doi.org/10.1016/j.adengl.2018.02.014.

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13

Bukhari, Rahaf, Waseem Alhawsawi, Aisha Ahmad Radin, Hawazin D. Jan, Khalid Al Hawsawi, and Marwan Al Ahmadi. "Punctate Palmoplantar Keratoderma: A Case Report of Type 1 (Buschke-Fischer-Brauer Disease)." Case Reports in Dermatology 11, no. 3 (2019): 292–96. http://dx.doi.org/10.1159/000503337.

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Punctate palmoplantar keratoderma is a rare hereditary palmoplantar keratoderma. Herein we report a 59-year-old male, otherwise healthy, who presented with a 25-year history of asymptomatic persistent slowly progressing skin lesions on both hands. The parents are non-consanguineous and none of his family members had similar lesions. Skin examination revealed multiple tiny keratotic pits on both palms. Punch skin biopsy from the palmar lesion revealed epidermal depression with an overlying column of compact orthokeratosis. Based on the above clinicopathological findings, a diagnosis of punctate

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14

Gamborg Nielsen, P. "Hereditary palmoplantar keratoderma in the northernmost county of Sweden." Acta Dermato-Venereologica 65, no. 3 (1985): 224–29. http://dx.doi.org/10.2340/0001555565224229.

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A papular and a diffuse variety of hereditary palmoplantar keratoderma (Unna Thost) are described. It was not possible to demonstrate any histopathological differences between the two varieties. Of the patients examined 36.2% were found to have dermatophytosis in addition to hereditary palmoplantar keratoderma. The hyperkeratosis was smooth and uniform in both varieties. When scaling and fissuring did occur they were signs of dermatophytosis and not part of the clinical picture. The examination of biopsies stained with H&E and PAS showed that dermatophytosis in patients with hereditary pal

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15

Swetha, Sridhar, Samayam Aneesh, and Anjan Kumar Patra. "A rare case of Vohwinkel’s syndrome." Our Dermatology Online 11, e (2020): e183.1-e183.3. http://dx.doi.org/10.7241/ourd.2020e.183.

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Keratoderma hereditarium mutilans or Vohwinkel’s syndrome is a rare autosomal dominant type of palmoplantar keratoderma characterized by honeycomb appearance, pseudoainhum leading to auto-amputation and stellate keratosis on knuckles. It’s mode of inheritance is autosomal dominant with mutation in loricrin and connexin 26 genes. We report the case of a 35-year-old female with alopecia universalis since birth and transgradient palmoplantar keratoderma, impaired hearing and pseudoainhum formation since childhood. This case is being reported to highlight the association of Vohwinkel’s syndrome wi

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16

Gupta, VedPrakash, and Isha Chaudhari. "Palmoplantar keratoderma with keratoconus." Middle East African Journal of Ophthalmology 25, no. 1 (2018): 49. http://dx.doi.org/10.4103/meajo.meajo_221_17.

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17

Lee Dellon, A. "Epidermalytic hereditary palmoplantar keratoderma." Journal of Hand Surgery 16, no. 1 (1991): 180. http://dx.doi.org/10.1016/s0363-5023(10)80040-1.

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18

Chen, K. L., Y. T. Cho, C. W. Yang, et al. "Olmutinib-induced palmoplantar keratoderma." British Journal of Dermatology 178, no. 2 (2017): e129-e131. http://dx.doi.org/10.1111/bjd.15935.

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19

Jacyk, W. K., and P. L. Bill. "Palmoplantar Keratoderma with Amyotrophy." Dermatology 176, no. 5 (1988): 251–56. http://dx.doi.org/10.1159/000248713.

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20

Xoagus, Elizabeth, Donald Hudson, and Sean Moodley. "Palmoplantar keratoderma surgical management." Journal of Plastic, Reconstructive & Aesthetic Surgery 67, no. 12 (2014): e316-e317. http://dx.doi.org/10.1016/j.bjps.2014.08.012.

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21

Fonseca, E. "Epidermolytic hereditary palmoplantar keratoderma." British Journal of Dermatology 113, no. 4 (1985): 505. http://dx.doi.org/10.1111/j.1365-2133.1985.tb02371.x.

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22

Rodriguez-Matta, Elisa M., Elisha M. Singer, and Olayemi Sokumbi. "Acquired Palmoplantar Keratoderma: Answer." American Journal of Dermatopathology 47, no. 3 (2025): 244–45. https://doi.org/10.1097/dad.0000000000002909.

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23

Tauseef, Shahzer, Ayesha Sharmeen, Mohammad Adil, and Murad Ahmad. "Keratosis Linearis with Ichthyosis Congenita and Sclerosing Keratoderma Syndrome – An Unusual Presentation." Indian Journal of Postgraduate Dermatology 2 (August 23, 2024): 114–17. http://dx.doi.org/10.25259/ijpgd_50_2024.

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Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome is a rare autosomal recessive disorder which is characterised by palmoplantar keratoderma, linear hyperkeratotic plaques, ichthyosiform scaling, pseudoainhum and plaques distributed linearly in the flexures. A 7-year-boy presented with ichthyosiform scaling over body since birth, hyperkeratotic plaques over palms and soles. On cutaneous examination, diffuse ichthyosiform scales were present all over body with non-transgradient type of palmoplantar keratoderma with bilaterally symmetrical linear hyperkeratotic plaq

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24

Grabovskaya, Olga V., Nataliya P. Teplyuk, Yuliya V. Колесова, and Dmitriy V. Ignatyev. "Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma." Russian Journal of Skin and Venereal Diseases 25, no. 4 (2022): 303–12. http://dx.doi.org/10.17816/dv111752.

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Palmoplantar keratoderma is a heterogeneous group of diseases, both hereditary and acquired, affecting, as a rule, the skin of the palms and soles in the form of focal or diffuse hyperkeratotic layers. Hereditary forms are characterized by a defect in the genes encoding certain structural components of keratinocytes, which leads to the corresponding clinical manifestations. The actual method of genomic sequencing has made it possible to identify the localization of defects in certain genes for specific types of hereditary palmoplantar keratoderma, however, despite the big step in diagnosis, th

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25

MORI, Makiko, Noriyuki HIRASHIMA, Masakazu OHTSU, et al. "Aquagenic Palmoplantar Keratoderma : A Report of Five Cases." Nishi Nihon Hifuka 76, no. 6 (2014): 555–61. http://dx.doi.org/10.2336/nishinihonhifu.76.555.

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26

Tiwary, AnupKumar, Sagarika Chatterjee, and DharmendraKumar Mishra. "Brunauer–Fuhs–Siemens palmoplantar keratoderma: A rare, striate type of focal palmoplantar keratoderma." Indian Journal of Paediatric Dermatology 17, no. 3 (2016): 246. http://dx.doi.org/10.4103/2319-7250.179500.

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27

Agashe, Akshata Kuwarlal, Saloni Abhijit Desai, Suraj Uday Pai, Atul Madhusudan Dongre, and Chitra Shivanand Nayak. "Fracture Reveals a Case of Spiny Keratoderma!" Indian Journal of Postgraduate Dermatology 2 (August 23, 2024): 118–20. http://dx.doi.org/10.25259/ijpgd_7_2024.

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Spiny keratoderma is a rare and likely underreported condition characterised by asymptomatic multiple pinpoint, keratotic projections over palms and soles. We report a case of a 50-year-old female with hereditary spiny keratoderma without any associated disease. Interestingly, the patient consulted us after a fracture of her right middle finger splinted, due to which she was unable to use her hand and wash it as usual and the consequent absence of exfoliation caused by hand usage and washing made the spines prominent. The characteristic clinical presentation with histopathologic and dermoscopi

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28

Almutawa, Fahad, Thusanth Thusaringam, Kevin Watters, Tenzin Gayden, Nada Jabado, and Denis Sasseville. "Pachyonychia Congenita (K16) with Unusual Features and Good Response to Acitretin." Case Reports in Dermatology 7, no. 2 (2015): 220–26. http://dx.doi.org/10.1159/000438920.

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Background: Pachyonychia congenita (PC) is a rare autosomal dominant disease whose main clinical features include hypertrophic onychodystrophy and palmoplantar keratoderma. The new classification is based on genetic variants with mutations in keratin KRT6A, KRT6B, KRT6C, KRT16, KRT17, and an unknown mutation. Here, we present a case of PC with unusual clinical and histological features and a favorable response to oral acitretin. Case: A 49-year-old male presented with diffuse and striate palmoplantar keratoderma, thickened nails, knuckle pads, and pseudoainhum. Histology showed compact hyperke

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29

Hashimoto, T., K. Teye, S. Numata, Y. Suga, T. Hamada, and N. Ishii. "Detection ofSERPINB7mutation can distinguish Nagashima-type palmoplantar keratoderma from other keratodermas with palmoplantar lesions." Clinical and Experimental Dermatology 42, no. 3 (2017): 342–45. http://dx.doi.org/10.1111/ced.13059.

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30

Foy, Hjordis M., Samran Tarmapai, Poovanon Eamchan, and Orapun Metdilogkul. "Chronic Arsenic Poisoning from Well Water in a Mining Area in Thailand." Asia Pacific Journal of Public Health 6, no. 3 (1992): 150–52. http://dx.doi.org/10.1177/101053959200600306.

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Endemic arsenic poisoning manifested by palmoplantar keratoderma and hyperpigmentation was surveyed in a village in a tin and wolfram mining area in southern Thailand where two cases of Bowen's carcinoma had occurred. Nine percent of examined adults randomly selected from 58 households were found to have skin manifestations of arsenic poisoning. Also, children with typical palmoplantar keratoderma were recognized, the youngest being four years old. A seven-year-old with severe keratoderma also had neurological manifestations and appeared mentally retarded. Arsenic concentration in shallow well

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31

Laxmi, K. Raghavendra, C. M. Prithvish, and H. Sanjay. "Cardiocutaneous Syndrome: Naxos Disease." International Journal of Preclinical and Clinical Research 3, no. 3 (2022): 83–86. http://dx.doi.org/10.51131/ijpccr/v3i3.22.30.

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Naxos disease is a recessively inherited condition, caused by mutation in genes encoding desmosomal proteins Plakoglobin. It is characterized by peculiar woolly hair, palmoplantar keratoderma with arrhythmogenic Right Ventricular dysplasia /cardiomyopathy. A syndrome (a variant of Naxos) with same cutaneous phenotype and predominant Left Ventricular involvement is CARVAJAL syndrome. Patients are at risk of sudden cardiac death due to cardiomyopathy. We herein report a rare case of Naxos disease in a 16 years old male born of a 3º consanguineous marriage, presented with features suggestive of c

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32

Singh, MP, Manishi Singh, Manika Singh, and Prashant Tripathi. "Clouston Syndrome with Palmoplantar Keratoderma." Journal of Indian Academy of Oral Medicine and Radiology 23 (July 2011): S425—S428. http://dx.doi.org/10.5005/jp-journals-10011-1188.

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33

Kaliyadan, Feroze, and Ajit Nambiar. "Palmoplantar keratoderma with dental abnormalities." Indian Dermatology Online Journal 5, no. 2 (2014): 232. http://dx.doi.org/10.4103/2229-5178.131152.

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34

Kalyana, Tanshum, Astha Arora, and G. P. Thami. "Palmoplantar keratoderma and woolly hair." Cosmoderma 2 (October 12, 2022): 91. http://dx.doi.org/10.25259/csdm_98_2022.

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35

Jha, Niharika, Bimal Kanish, and Anuradha Bhatia. "Imatinib mesylate-induced palmoplantar keratoderma." Indian Journal of Drugs in Dermatology 7, no. 1 (2021): 49. http://dx.doi.org/10.4103/ijdd.ijdd_17_20.

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36

FITZGERALD, D. A., and J. L. VERBOV. "Hereditary palmoplantar keratoderma with deafness." British Journal of Dermatology 134, no. 5 (1996): 939–42. http://dx.doi.org/10.1046/j.1365-2133.1996.133868.x.

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37

Miller, Roling, Spiers, Davies, Rawlings, and Leyden. "Palmoplantar keratoderma associated with hypothyroidism." British Journal of Dermatology 139, no. 4 (1998): 741–42. http://dx.doi.org/10.1046/j.1365-2133.1998.02480.x.

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38

FITZGERALD, D. A., and J. L. VERBOV. "Hereditary palmoplantar keratoderma with deafness." British Journal of Dermatology 134, no. 5 (1996): 939–42. http://dx.doi.org/10.1111/j.1365-2133.1996.tb06331.x.

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39

Alsaleh, Q. A., and A. S. Teebi. "Autosomal recessive epidermolytic palmoplantar keratoderma." Journal of Medical Genetics 27, no. 8 (1990): 519–22. http://dx.doi.org/10.1136/jmg.27.8.519.

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40

Barman, KrishnaDeb, Sudhanshu Sharma, VijayKumar Garg, and Shalu Jain. "Unilateral linear punctate palmoplantar keratoderma." Indian Journal of Dermatology, Venereology, and Leprology 78, no. 1 (2012): 85. http://dx.doi.org/10.4103/0378-6323.90953.

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41

Yilmaz, P., M. Medvecz, J. Kohlhase, J. Küsel, J. Fischer, and C. Has. "Alitretinoin in punctate palmoplantar keratoderma." British Journal of Dermatology 180, no. 4 (2018): 931–32. http://dx.doi.org/10.1111/bjd.17336.

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42

Nielsen, Povl Gamborg. "Hereditary Palmoplantar Keratoderma and Dermatophytosis." International Journal of Dermatology 27, no. 4 (1988): 223–31. http://dx.doi.org/10.1111/j.1365-4362.1988.tb03213.x.

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43

Sehgal, Virendra N., Devinder M. Thappa, and Sanjiv Jain. "Palmoplantar Keratoderma with Cutaneous Horns." International Journal of Dermatology 31, no. 5 (1992): 369–70. http://dx.doi.org/10.1111/j.1365-4362.1992.tb03967.x.

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44

Das, Anupam, Dhiraj Kumar, and Nilay Kanti Das. "Diffuse non-epidermolytic Palmoplantar Keratoderma." Indian Pediatrics 50, no. 10 (2013): 979. http://dx.doi.org/10.1007/s13312-013-0249-z.

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45

Singh, Sanjay, Prateek Sondhi, and Gomathy Sethuraman. "Palmoplantar keratoderma with curly hair." Pediatric Dermatology 34, no. 6 (2017): 724–25. http://dx.doi.org/10.1111/pde.13307.

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46

Verbov, J. "Palmoplantar keratoderma, deafness and atopy." British Journal of Dermatology 116, no. 6 (1987): 881. http://dx.doi.org/10.1111/j.1365-2133.1987.tb04914.x.

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47

Itin, Peter H., and Stephan Lautenschlager. "Palmoplantar keratoderma and associated syndromes." Seminars in Dermatology 14, no. 2 (1995): 152–61. http://dx.doi.org/10.1016/s1085-5629(05)80012-4.

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48

Wevers, Andrea, Andreas Kuhn, and Gustav Mahrle. "Palmoplantar keratoderma with tonotubular keratin." Journal of the American Academy of Dermatology 24, no. 4 (1991): 638–42. http://dx.doi.org/10.1016/0190-9622(91)70099-n.

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49

Khlebnikova, A. N., and O. V. Dorokhina. "Punctate palmoplantar keratoderma, porokeratotic type." Klinicheskaya dermatologiya i venerologiya 22, no. 4 (2023): 441. http://dx.doi.org/10.17116/klinderma202322041441.

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50

Bhati, Surendra Singh, Anmol Bhargava, Pramey Deshpande, and Swati Sahu. "Olmsted Syndrome: A Case Report of Two Brothers." Indian Journal of Paediatric Dermatology 25, no. 4 (2024): 340–42. https://doi.org/10.4103/ijpd.ijpd_126_24.

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Abstract Olmsted syndrome is a rare disease characterized by severe mutilating transgradient keratoderma with prominent periorificial hyperkeratosis. A total of 73 cases have been reported worldwide. We hereby report the cases of two brothers who were diagnosed as Olmsted syndrome, who presented with periorificial hyperkeratosis and palmoplantar keratoderma.

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