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Journal articles on the topic 'Panaxytriol'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Satoh, Mitsuru, Masayoshi Ishii, Mitsuo Watanabe, Kimiaki Isobe, Taketo Uchiyama, and Yasuo Fujimoto. "Absolute Structure of Panaxytriol." CHEMICAL & PHARMACEUTICAL BULLETIN 50, no. 1 (2002): 126–28. http://dx.doi.org/10.1248/cpb.50.126.

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2

Prasad, Kavirayani R., and Bandita Swain. "Total synthesis of panaxytriol and panaxydiol." Tetrahedron: Asymmetry 22, no. 12 (2011): 1261–65. http://dx.doi.org/10.1016/j.tetasy.2011.07.007.

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3

SATOH, Mitsuru, Naoki TAKEUCHI, and Yasuo FUJIMOTO. "Synthesis and Absolute Configuration of Panaxytriol." CHEMICAL & PHARMACEUTICAL BULLETIN 45, no. 7 (1997): 1114–16. http://dx.doi.org/10.1248/cpb.45.1114.

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4

Satoh, Mitsuru, Masayoshi Ishii, Mitsuo Watanabe, Kimiaki Isobe, Taketo Uchiyama, and Yasuo Fujimoto. "ChemInform Abstract: Absolute Structure of Panaxytriol." ChemInform 33, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.200229224.

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5

Wang, Bang-Yan, Chen-Hao Zhu, Xue-Qiong Yang та ін. "Inducing Intermediates in Biotransformation of Natural Polyacetylene and A Novel Spiro-γ-Lactone from Red Ginseng by Solid Co-Culture of Two Gut Chaetomium globosum and The Potential Bioactivity Modification by Oxidative Metabolism". Molecules 25, № 5 (2020): 1216. http://dx.doi.org/10.3390/molecules25051216.

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The ω-hydroxyl-panaxytriol (1) and ω-hydroxyl-dihydropanaxytriol (2)—are rare examples of polyacetylene metabolism by microbial transformation, and these new metabolites (1, 2) from fermented red ginseng (FRG) by solid co-culture induction of two Chaetomium globosum should be the intermediates of biotransformation of panaxylactone (metabolite A). The metabolic pathway of panaxylactone was also exhibited. The ingredients of red ginseng (RG) also induced the production of rare 6/5/5 tricyclic ring spiro-γ-lactone skeleton (3). The ω-hydroxylation of new intermediates (1, 2) decreases cytotoxicit

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6

SATOH, M., N. TAKEUCHI, and Y. FUJIMOTO. "ChemInform Abstract: Synthesis and Absolute Configuration of Panaxytriol." ChemInform 28, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199751278.

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7

Hiramatsu, Genki, Kosuke Matsuda, Daisuke Uta, Kenichi Mihara, Ysuhunobu Andoh, and Toshiaki Kume. "Inhibitory effect of panaxytriol on thelipopolysaccharide-induced microglial activation." Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (2021): 2—Y—F1–1. http://dx.doi.org/10.1254/jpssuppl.94.0_2-y-f1-1.

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8

Hiramatsu, Genki, Daisuke Uta, Kenichi Mihara, Tsugunobu Andoh, and Toshiaki Kume. "Inhibitory effect of panaxytriol on BV-2 microglial cell activation." Journal of Pharmacological Sciences 145, no. 3 (2021): 273–78. http://dx.doi.org/10.1016/j.jphs.2021.01.001.

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9

Yun, Heedong, and Samuel J. Danishefsky. "Straightforward Synthesis of Panaxytriol: An Active Component of Red Ginseng." Journal of Organic Chemistry 68, no. 11 (2003): 4519–22. http://dx.doi.org/10.1021/jo0341665.

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10

Mao, Jianyou, Jiangchun Zhong, Bo Wang, et al. "Synthesis of panaxytriol and its stereoisomers as potential antitumor drugs." Tetrahedron: Asymmetry 27, no. 7-8 (2016): 330–37. http://dx.doi.org/10.1016/j.tetasy.2016.03.005.

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11

Bae, Eun-Ah, Myung Joo Han, Nam-In Baek, and Dong-Hyun Kim. "In Vitro Anti-Helicobacterpylori activity of Panaxytriol isolated from Ginseng." Archives of Pharmacal Research 24, no. 4 (2001): 297–99. http://dx.doi.org/10.1007/bf02975095.

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12

Katano, Mitsuo, Tetsuya Saita, Hiroshi Yamamoto, Masato Mori, and Hisashi Matsunaga. "Potentiation of cytotoxicity of mitomycin C by a polyacetylenic alcohol, panaxytriol." Cancer Chemotherapy and Pharmacology 33, no. 4 (1994): 291–97. http://dx.doi.org/10.1007/s002800050055.

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13

Matsunaga, Hisashi, Mitsuo Katano, Tetsuya Saita, Hiroshi Yamamoto, and Masato Mori. "Potentiation of cytotoxicity of mitomycin C bt a polyacetylenic alcohol, panaxytriol." Cancer Chemotherapy and Pharmacology 33, no. 4 (1994): 291–97. http://dx.doi.org/10.1007/bf00685902.

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14

SAITA, Tetsuya, Mitsuo KATANO, Hisashi MATSUNAGA, Isao KOUNO, Hiroshi FUJITO, and Masato MORI. "Screening of Polyacetylenic Alcohols in Crude Drugs Using the ELISA for Panaxytriol." Biological & Pharmaceutical Bulletin 18, no. 7 (1995): 933–37. http://dx.doi.org/10.1248/bpb.18.933.

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15

Hiramatsu, Genki, Kosuke Matsuda, Daisuke Uta, Kenichi Mihara, and Toshiaki Kume. "Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation in Vivo." Biological and Pharmaceutical Bulletin 44, no. 7 (2021): 1024–28. http://dx.doi.org/10.1248/bpb.b21-00288.

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16

Xie, Qian, Bin Li, Jialong Fan, et al. "Biomimetic hybrid-cell membrane nanoparticles loaded with panaxytriol for breast cancer combinational therapy." Materials & Design 223 (November 2022): 111219. http://dx.doi.org/10.1016/j.matdes.2022.111219.

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17

Lu, Wei, Guangrong Zheng, and Junchao Cai. "First Total Synthesis of Panaxytriol, a Potent Antitumor Agent Isolated from Panax Ginseng." Synlett 1998, no. 7 (1998): 737–38. http://dx.doi.org/10.1055/s-1998-1775.

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18

SAITA, Tetsuya, Hisashi MATSUNAGA, Hiroshi YAMAMOTO, et al. "A Highly Sensitive Enzyme-Linked Immunosorbent Assay(ELISA) for Antitumor Polyacetylenic Alcohol, Panaxytriol." Biological & Pharmaceutical Bulletin 17, no. 6 (1994): 798–802. http://dx.doi.org/10.1248/bpb.17.798.

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19

Yadav, J. S., and Arup Maiti. "Asymmetric total syntheses of panaxytriol and panaxydol, potent antitumor agents from Panax ginseng." Tetrahedron 58, no. 24 (2002): 4955–61. http://dx.doi.org/10.1016/s0040-4020(02)00423-4.

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20

Chou, T. C., H. Dong, X. Zhang, et al. "Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol." Proceedings of the National Academy of Sciences 108, no. 34 (2011): 14336–41. http://dx.doi.org/10.1073/pnas.1111332108.

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21

Zhang, Lingming, Jingdi Yan, Jianming Liu, Chao Meng, Fanglan Liu та Chunhua Xia. "Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα". Phytomedicine 101 (липень 2022): 154097. http://dx.doi.org/10.1016/j.phymed.2022.154097.

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22

MATSUNAGA, Hisashi, Mitsuo KATANO, Hiroshi YAMAMOTO, Masato MORI, and Katsumi TAKATA. "Studies on the panaxytriol of Panax ginseng C.A. MEYER. Isolation, determination and antitumor activity." CHEMICAL & PHARMACEUTICAL BULLETIN 37, no. 5 (1989): 1279–81. http://dx.doi.org/10.1248/cpb.37.1279.

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23

Lu, Wei, Guangrong Zheng, Daxin Gao, and Junchao Cai. "Syntheses of two diastereoisomers of panaxytriol, a potent antitumor agent isolated from panax ginseng." Tetrahedron 55, no. 23 (1999): 7157–68. http://dx.doi.org/10.1016/s0040-4020(99)00352-x.

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24

Gurjar, Mukund K., V. Sylesh Kumar, and B. Venkateswara Rao. "Synthesis of a new type of antitumour agent panaxytriol: Synthesis of its four diastereomers." Tetrahedron 55, no. 43 (1999): 12563–76. http://dx.doi.org/10.1016/s0040-4020(99)00732-2.

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25

KOBAYASHI, Motomasa, Taifo MAHMUD, Takashi UMEZOME, and Isao KITAGAWA. "The Absolute Stereostructure of Panaxytriol,a Biologically Active Diacetylenic Acetogenin, from Ginseng Radix Rubra." CHEMICAL & PHARMACEUTICAL BULLETIN 43, no. 9 (1995): 1595–97. http://dx.doi.org/10.1248/cpb.43.1595.

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26

Wu, Jie, Na Yao, Qingqing Hu, et al. "Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway." Phytotherapy Research 33, no. 4 (2019): 968–75. http://dx.doi.org/10.1002/ptr.6290.

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27

Yan, Jingdi, Qi Gu, Chao Meng, Jianming Liu, Fanglan Liu, and Chunhua Xia. "Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements." Journal of Ethnopharmacology 310 (June 2023): 116398. http://dx.doi.org/10.1016/j.jep.2023.116398.

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28

Matsunaga, H., T. Saita, F. Nagumo, M. Mori, and M. Katano. "A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration." Cancer Chemotherapy and Pharmacology 35, no. 4 (1995): 291–96. http://dx.doi.org/10.1007/s002800050235.

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29

Matsunaga, H., T. Saita, F. Nagumo, M. Mori, and M. Katano. "A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration." Cancer Chemotherapy and Pharmacology 35, no. 4 (1995): 291–96. http://dx.doi.org/10.1007/bf00689447.

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30

LU, W., G. ZHENG, and J. CAI. "ChemInform Abstract: First Total Synthesis of Panaxytriol, a Potent Antitumor Agent Isolated from Panax ginseng." ChemInform 29, no. 43 (2010): no. http://dx.doi.org/10.1002/chin.199843277.

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31

Yadav, J. S., and Arup Maiti. "ChemInform Abstract: Asymmetric Total Syntheses of Panaxytriol and Panaxydol, Potent Antitumor Agents from Panax ginseng." ChemInform 33, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.200241228.

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32

Kim, Ji Yeon, Ki-Won Lee, Sun-Ho Kim, Jae Joon Wee, Young-Suk Kim, and Hyong Joo Lee. "Inhibitory Effect of Tumor Cell Proliferation and Induction of G2/M Cell Cycle Arrest by Panaxytriol." Planta Medica 68, no. 2 (2002): 119–22. http://dx.doi.org/10.1055/s-2002-20240.

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33

Ng, Fay, Heedong Yun, Xiaoguang Lei, et al. "(3R,9R,10R)-Panaxytriol: a molecular-based nutraceutical with possible application to cancer prevention and treatment." Tetrahedron Letters 49, no. 50 (2008): 7178–79. http://dx.doi.org/10.1016/j.tetlet.2008.09.169.

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34

Lu, Wei, Guangrong Zheng, Daxin Gao, and Junchao Cai. "ChemInform Abstract: Syntheses of Two Diastereoisomers of Panaxytriol, a Potent Antitumor Agent Isolated from Panax ginseng." ChemInform 30, no. 35 (2010): no. http://dx.doi.org/10.1002/chin.199935276.

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35

KOBAYASHI, M., T. MAHMUD, T. UMEZOME, and I. KITAGAWA. "ChemInform Abstract: The Absolute Stereostructure of Panaxytriol, a Biologically Active Diacetylenic Acetogenine from Ginseng Radix Rubra." ChemInform 27, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199611291.

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36

Matsunaga, Hisashi, Mitsuo Katano, Hiroshi Yamamoto, Masato Mori, Katsumi Takata, and Masatoshi Nishi. "Determination of panaxytriol, a new type of tumour growth inhibitor from Panax ginseng, by capillary gas chromatography." Journal of Chromatography A 481 (January 1989): 368–72. http://dx.doi.org/10.1016/s0021-9673(01)96781-0.

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37

Cho, Eun Jin, and Daesung Lee. "Total Synthesis of (3R,9R,10R)-Panaxytriol via Tandem Metathesis and Metallotropic [1,3]-Shift as a Key Step." Organic Letters 10, no. 2 (2008): 257–59. http://dx.doi.org/10.1021/ol702651s.

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38

Hu, Qingqing, Na Yao, Jie Wu, et al. "Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor." Biochemical Pharmacology 159 (January 2019): 32–39. http://dx.doi.org/10.1016/j.bcp.2018.11.009.

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39

Yun, Heedong, Ting-Chao Chou, Huajin Dong, Yuan Tian, Yue-ming Li, and Samuel J. Danishefsky. "Total Synthesis as a Resource in Drug Discovery: The First In Vivo Evaluation of Panaxytriol and Its Derivatives." Journal of Organic Chemistry 70, no. 25 (2005): 10375–80. http://dx.doi.org/10.1021/jo0515475.

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40

Kim, Ranhee, So-Ri Son, Na-Kyung Lee, et al. "Cytotoxic Properties of C17 Polyacetylenes from the Fresh Roots of Panax ginseng on Human Epithelial Ovarian Cancer Cells." Molecules 27, no. 20 (2022): 7027. http://dx.doi.org/10.3390/molecules27207027.

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Although C17 polyacetylenes from Panax ginseng exhibit cytotoxic properties against various tumor cells, there have been few experiments on epithelial ovarian carcinoma cells. This study aimed to investigate the cytotoxic effects of C17 polyacetylenes from P. ginseng against ovarian cancer cell lines. Four unreported (1–4) and fifteen known (5–19) C17 polyacetylenes were obtained from the roots of P. ginseng using repeated chromatography (open column, MPLC, and preparative HPLC). The chemical structures of all the compounds were determined by analyzing their spectroscopic data (NMR, IR, and op

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41

He, Fang, Wen Zhang, Caiwen Zeng, et al. "Mechanism of Action of Panaxytriol on Midazolam 1′-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes." Biological & Pharmaceutical Bulletin 38, no. 10 (2015): 1470–77. http://dx.doi.org/10.1248/bpb.b15-00143.

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42

Halim, Marlin, Dominic J. Yee, and Dalibor Sames. "Imaging Induction of Cytoprotective Enzymes in Intact Human Cells: Coumberone, a Metabolic Reporter for Human AKR1C Enzymes Reveals Activation by Panaxytriol, an Active Component of Red Ginseng." Journal of the American Chemical Society 130, no. 43 (2008): 14123–28. http://dx.doi.org/10.1021/ja801245y.

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43

Mayer, Sandra F., Andreas Steinreiber, Romano V. A. Orru, and Kurt Faber. "Chemoenzymatic Asymmetric Total Syntheses of Antitumor Agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol fromPanaxginsengUsing an Enantioconvergent Enzyme-Triggered Cascade Reaction." Journal of Organic Chemistry 67, no. 26 (2002): 9115–21. http://dx.doi.org/10.1021/jo020073w.

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44

"Synthesis of (3R,9R,10R)-Panaxytriol." Synfacts 2008, no. 06 (2008): 0561. http://dx.doi.org/10.1055/s-2008-1072607.

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45

Yun, Heedong, and Samuel J. Danishefsky. "Straightforward Synthesis of Panaxytriol: An Active Component of Red Ginseng." ChemInform 34, no. 39 (2003). http://dx.doi.org/10.1002/chin.200339214.

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46

Yun, Heedong, Ting-Chao Chou, Huajin Dong, Yuan Tian, Yue-ming Li, and Samuel J. Danishefsky. "Total Synthesis as a Resource in Drug Discovery: The First in vivo Evaluation of Panaxytriol (I) and Its Derivatives." ChemInform 37, no. 19 (2006). http://dx.doi.org/10.1002/chin.200619211.

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47

Cho, Eun Jin, and Daesung Lee. "ChemInform Abstract: Total Synthesis of (3R,9R,10R)-Panaxytriol via Tandem Metathesis and Metallotropic [1,3]-Shift as a Key Step." ChemInform 39, no. 25 (2008). http://dx.doi.org/10.1002/chin.200825210.

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48

Mayer, Sandra F., Andreas Steinreiber, Romano V. A. Orru, and Kurt Faber. "Chemoenzymatic Asymmetric Total Syntheses of Antitumor Agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol (Ia) and (Ib) and (R)- and (S)-Falcarinol (IIa) and (IIb) from Panax ginseng Using an Enantioconvergent Enzyme-Triggered Cascade Reaction." ChemInform 34, no. 20 (2003). http://dx.doi.org/10.1002/chin.200320236.

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