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Journal articles on the topic 'Pancreas β-cells regeneration'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pylaev, T. E., I. V. Smyshlyaeva та E. B. Popyhova. "Regeneration of β-cells of the islet apparatus of the pancreas. Literature review". Diabetes mellitus 25, № 4 (2022): 395–404. http://dx.doi.org/10.14341/dm12872.

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Diabetes of both type 1 and type 2 is characterized by a progressive loss of β-cell mass, which contributes to the disruption of glucose homeostasis. The optimal antidiabetic therapy would be simple replacement of lost cells, but at present, many researchers have shown that the pancreas (PZ) of adults has a limited regenerative potential. In this regard, significant efforts of researchers are directed to methods of inducing the proliferation of β-cells, stimulating the formation of β-cells from alternative endogenous sources and/or the generation of β-cells from pluripotent stem cells. Factors

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Beamish, Christine A., Sofia Mehta, Brenda J. Strutt, Subrata Chakrabarti, Manami Hara та David J. Hill. "Decrease in Ins+Glut2LO β-cells with advancing age in mouse and human pancreas". Journal of Endocrinology 233, № 3 (2017): 229–41. http://dx.doi.org/10.1530/joe-16-0475.

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The presence and location of resident pancreatic β-cell progenitors is controversial. A subpopulation of insulin-expressing but glucose transporter-2-low (Ins+Glut2LO) cells may represent multipotent pancreatic progenitors in adult mouse and in human islets, and they are enriched in small, extra-islet β-cell clusters (<5 β cells) in mice. Here, we sought to identify and compare the ontogeny of these cells in mouse and human pancreata throughout life. Mouse pancreata were collected at postnatal days 7, 14, 21, 28, and at 3, 6, 12, and 18 months of age, and in the first 28 days after β-cell m

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Balaji, Shruti, Tiziana Napolitano, Serena Silvano, et al. "Epigenetic Control of Pancreatic Regeneration in Diabetes." Genes 9, no. 9 (2018): 448. http://dx.doi.org/10.3390/genes9090448.

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Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development, making use of diverse cell sources or converting pre-existing pancreatic cells. Despite impressive progresses and promising successes, it appears that we still need to gain further insight into the molecular mechanisms underlying β-cell development. This becomes even more obviou

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Anggi, Viani, Joni Tandi, and Veronika Veronika. "TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN." Jurnal Ilmiah Manuntung 6, no. 1 (2020): 24. http://dx.doi.org/10.51352/jim.v6i1.294.

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This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given g

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Karampelias, Christos, Bianca Băloiu, Birgit Rathkolb та ін. "Examining the liver–pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regeneration". Life Science Alliance 7, № 11 (2024): e202402771. http://dx.doi.org/10.26508/lsa.202402771.

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Regeneration of insulin-producing β-cells is an alternative avenue to manage diabetes, and it is crucial to unravel this process in vivo during physiological responses to the lack of β-cells. Here, we aimed to characterize how hepatocytes can contribute to β-cell regeneration, either directly or indirectly via secreted proteins or metabolites, in a zebrafish model of β-cell loss. Using lineage tracing, we show that hepatocytes do not directly convert into β-cells even under extreme β-cell ablation conditions. A transcriptomic analysis of isolated hepatocytes after β-cell ablation displayed alt

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Butler, Alexandra E., Sangeeta Dhawan, Jonathan Hoang та ін. "β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation". Journal of Clinical Endocrinology & Metabolism 101, № 2 (2016): 523–32. http://dx.doi.org/10.1210/jc.2015-3566.

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Abstract Context: Type 2 diabetes is characterized by a β-cell deficit and a progressive defect in β-cell function. It has been proposed that the deficit in β-cells may be due to β-cell degranulation and transdifferentiation to other endocrine cell types. Objective: The objective of the study was to establish the potential impact of β-cell dedifferentiation and transdifferentiation on β-cell deficit in type 2 diabetes and to consider the alternative that cells with an incomplete identity may be newly forming rather than dedifferentiated. Design, Setting, and Participants: Pancreata obtained at

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Bonner-Weir, Susan, Akari Inada, Shigeru Yatoh та ін. "Transdifferentiation of pancreatic ductal cells to endocrine β-cells". Biochemical Society Transactions 36, № 3 (2008): 353–56. http://dx.doi.org/10.1042/bst0360353.

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The regenerative process in the pancreas is of particular interest, since diabetes, whether Type 1 or Type 2, results from an inadequate amount of insulin-producing β-cells. Islet neogenesis, or the formation of new islets, seen as budding of hormone-positive cells from the ductal epithelium, has long been considered to be one of the mechanisms of normal islet growth after birth and in regeneration, and suggested the presence of pancreatic stem cells. Results from the rat regeneration model of partial pancreatectomy led us to hypothesize that differentiated pancreatic ductal cells were the pan

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Köhler, Christina U., Marvin Olewinski, Andrea Tannapfel, Wolfgang E. Schmidt, Helga Fritsch та Juris J. Meier. "Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas". American Journal of Physiology-Endocrinology and Metabolism 300, № 1 (2011): E221—E230. http://dx.doi.org/10.1152/ajpendo.00496.2010.

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β-Cell regeneration declines with aging, but the molecular mechanisms controlling β-cell replication in humans are not well understood. We compared the expression of selected cell cycle proteins in prenatal and adult tissue and examined the association of these proteins with β-cell replication. Pancreatic tissue from a total of 20 human fetuses and adults was stained for Ki67, cyclin D3, p16 and p27, and insulin. The β-cellular expression of these cell cycle proteins was determined. The frequency of β-cell replication was lower in adult compared with prenatal β-cells (<0.5 vs. 3.4 ± 0.5%, r

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Azahari, Nuraniza, Nor Azwani Mohd-Shukri та Muhammad Muzaffar Ali Khan Khattak. "Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model". Advances in Obesity, Weight Management & Control 10, № 2 (2021): 33–38. http://dx.doi.org/10.15406/aowmc.2020.10.00302.

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Introduction:The aim of this study was to evaluate the effect protein containing adiponectin from the adipocytes on the regeneration of pancreatic β-cells in rates previously treated with (STZ). Therefore, adipocytes from different sources were extracted for protein (adipokines) and the effect was evaluated on pancreatic β-cell regeneration. Methods: The protein extracts from trimmed off abdominal adipose tissues of meat sources, namely chicken, beef and lamb, were used in the present study. The fats were removed, and protein were isolated, and hydrolysate were prepared and injected to rats. T

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Movassat, Jamileh, та Bernard Portha. "Early administration of keratinocyte growth factor improves β-cell regeneration in rat with streptozotocin-induced diabetes". Journal of Endocrinology 195, № 2 (2007): 333–40. http://dx.doi.org/10.1677/joe-07-0098.

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The aim of our study was to investigate the ability of keratinocyte growth factor (KGF; palifermin) in regulating β-cell growth in normal newborn rats and in rats with neonatal diabetes. Wistar rats were injected with streptozotocin (STZ) to induce diabetes on the dayof birth. From days 2 to 6 after birth, animals received a daily s.c. injection of KGF (STZ/KGF group) and at the dose of 3 mg/kg body weight or saline solution (STZ groups). A group of non-diabetic Wistar rats was treated either with saline (Wistar group) or with KGF from days 2 to 6 after birth at the dose of 3 mg/kg body weight

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Lee, Catherine S., Diva D. De León, Klaus H. Kaestner, and Doris A. Stoffers. "Regeneration of Pancreatic Islets After Partial Pancreatectomy in Mice Does Not Involve the Reactivation of Neurogenin-3." Diabetes 55, no. 2 (2006): 269–72. http://dx.doi.org/10.2337/diabetes.55.02.06.db05-1300.

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Understanding the factors and mechanisms involved in β-cell regeneration will guide therapeutic efforts to augment β-cell mass in patients with diabetes. Neurogenin-3 (Ngn3) is a bHLH transcription factor that responds to Notch signaling and whose expression marks endocrine progenitors. During fetal development, all endocrine cells are derived from Ngn3+ precursors. Although expression of Ngn3 in the adult pancreas has not been reported, it has been suggested that islet regeneration in adult organisms recapitulates embryonic developmental pathways. Here, we investigated whether β-cell regenera

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Attanayake, Anoja Priyadarshani, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa та Chitra Pathirana. "β-cell Regenerative Potential of Selected Herbal Extracts in Alloxan Induced Diabetic Rats". Current Drug Discovery Technologies 16, № 3 (2019): 278–84. http://dx.doi.org/10.2174/1570163815666180418153024.

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Background:Effective β-cell regeneration is a recognized therapeutic strategy in the treatment of type 1 diabetes mellitus. Regeneration of β-cells could be achieved via exogenous natural sources as medicinal plant extracts. Medicinal plants selected for the investigation were Spondias pinnata (Linn. f.) Kurz, Coccinia grandis (L.) Voigt and Gmelina arborea Roxb. The objective was to determine the β-cell regenerative potential of these plant extracts in alloxan-induced diabetic rats. Alloxan monohydrate was used to induce diabetes (150 mg/kg, ip).Methods:Wistar albino rats were divided into si

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Stahlman, Mildred T., Mary E. Gray та Jeffrey A. Whitsett. "Temporal-Spatial Distribution of Hepatocyte Nuclear Factor-3β in Developing Human Lung and Other Foregut Derivatives". Journal of Histochemistry & Cytochemistry 46, № 8 (1998): 955–62. http://dx.doi.org/10.1177/002215549804600809.

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SUMMARY We assessed the temporal-spatial distribution of hepatocyte nuclear factor-3β (HNF-3β) in developing human lung and other foregut derivatives. Tissue from 31 fetuses (10-40 weeks) and 24 infants with hyaline membrane disease (HMD) or bronchopulmonary dysplasia (BPD) (2 days to 7 months) was studied. HNF-3β was detected in nuclei of epithelial cells of trachea and of conducting and terminal airways at 10 weeks. Thereafter, epithelial nuclei were immunolabeled more widely in peripheral than proximal airways. HNF-3β was confined to bronchiolo-alveolar portals and Type II cells in nonfetal

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Li, Bing, Xiao Wang, and Jun-Li Liu. "Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 2 (2010): G413—G421. http://dx.doi.org/10.1152/ajpgi.00500.2009.

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Reg proteins are normally expressed in pancreatic acinar cells, and the level of several of these proteins was significantly induced upon damage to the endocrine or exocrine pancreas. It has been established that Reg1 and pancreatic islet neogenesis-associated protein [INGAP, Reg3δ] promote the growth or regeneration of the endocrine islet cells. Recent reports suggest that Reg2 is an autoantigen normally expressed in islet β-cells. Reg2 overexpression in vitro offered protection to insulinoma cells. Overexpressed Reg3α increased cyclin D1 and CDK4 levels and the rate of proliferation in insul

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Park, So-young, Boyoung Kim, Yun Kyung Lee та ін. "Silk Fibroin Promotes the Regeneration of Pancreatic β-Cells in the C57BL/KsJ-Leprdb/db Mouse". Molecules 25, № 14 (2020): 3259. http://dx.doi.org/10.3390/molecules25143259.

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Diabetes mellitus is a chronic metabolic disease, and its progression leads to serious complications. Although various novel therapeutic approaches for diabetes mellitus have developed in the last three decades, its prevalence has been rising more rapidly worldwide. Silk-related materials have been used as anti-diabetic remedies in Oriental medicine and many studies have shown the effects of silk fibroin (SF) in both in vitro and in vivo models. In our previous works, we reported that hydrolyzed SF improved the survival of HIT-T15 cells under high glucose conditions and ameliorated diabetic dy

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Tyurenkov, I. N., T. I. Faibisovich, M. A. Dubrovina, D. A. Bakulin, and D. V. Kurkin. "Gabaergic System in the Regulation of the Functioning of Pancreas Beta-Cells in Normal Physiological Conditions and in Diabetes." Успехи физиологических наук 54, no. 2 (2023): 86–104. http://dx.doi.org/10.31857/s030117982302008x.

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Abstract—The incidence of diabetes mellitus (DM) is steadily increasing all over the world, and at the same time there is an increase in its complications, which are the main causes of early disability and premature death. The pathogenesis of DM is based on a steady decrease in pancreatic β-cells. A decrease in β-cell mass leads to a decrease in insulin production and the development of hyperglycemia and associated severe complications. Therefore, the need to prevent the death of β-cells and stimulate their regeneration is obvious. In recent literature, much attention has been paid to the role

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Kim, Hyo‐Sup, та Moon‐Kyu Lee. "β‐Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas". Journal of Diabetes Investigation 7, № 3 (2016): 286–96. http://dx.doi.org/10.1111/jdi.12475.

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Meier, Juris J., Christina U. Köhler, Bacel Alkhatib та ін. "β-cell development and turnover during prenatal life in humans". European Journal of Endocrinology 162, № 3 (2010): 559–68. http://dx.doi.org/10.1530/eje-09-1053.

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Introductionβ-cell regeneration is an area under active investigation for the future treatment of diabetes, but little is known about the patterns and dynamics of prenatal β-cell development in humans. In particular, the quantitative changes in β-cell mass in the developing pancreas have not been elucidated in detail. We addressed the following questions in prenatal humans: i) what is the timing of β-cell occurrence and islet growth? ii) What are the dynamics of β-cell replication and apoptosis?MethodsPancreatic tissue was obtained from 65 human embryos and foetuses aged between 8 weeks post c

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Tchamgoue, Armelle D., Paul DD Dzeufiet, Jules-Roger Kuiata, and Gabriel A. Agbor. "Costus afer modulates the activities of glycolytic and gluconeogenic enzymes in streptozotocin induced diabetic rats." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 63–70. http://dx.doi.org/10.22270/jddt.v10i4-s.4270.

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Background: Glycolytic enzymes (Hexokinase and α-glucosidase) and gluconeogenic enzymes (Glucose-6-phosphatase and fructose-1,6-disphosphatase) control carbohydrate metabolism and hence glucose hemostasis, an important approach for the control of diabetes. The present study was carried out to evaluate the effect of hydro-ethanolic leaf extract of Costus afer on these enzymes. Materials and methods: Streptozotocin-induced diabetic rats were administered hydro-ethanolic leaf extract of Costus afer (250, 500 and 1000 mg/kg body weight) orally for 8 weeks. Effect of the extract was monitored

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Lu, Yarong, André Ponton, Hiroshi Okamoto, Shin Takasawa, Pedro L. Herrera, and Jun-Li Liu. "Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas." American Journal of Physiology-Endocrinology and Metabolism 291, no. 1 (2006): E50—E58. http://dx.doi.org/10.1152/ajpendo.00596.2005.

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We have recently reported that Pdx1-Cre-mediated whole pancreas inactivation of IGF-I gene [in pancreatic-specific IGF-I gene-deficient (PID) mice] results in increased β-cell mass and significant protection against both type 1 and type 2 diabetes. Because the phenotype is unlikely a direct consequence of IGF-I deficiency, the present study was designed to explore possible activation of proislet factors in PID mice by using a whole genome DNA microarray. As a result, multiple members of the Reg family genes (Reg2, -3α, and -3β, previously not known to promote islet cell growth) were significan

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Tidjane, Nejla, Louis Gaboury, and Réjean Couture. "Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612." Biological Chemistry 397, no. 4 (2016): 323–36. http://dx.doi.org/10.1515/hsz-2015-0230.

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Abstract The mechanism by which kinin B1 receptor (B1R) contributes to type 1 diabetes is addressed by determining the impact of its inhibition on diabetes and on its pancreatic expression and cellular localisation on immunocompetent cells and primary sensory C-fibres. Rats were made diabetic with streptozotocin (STZ). On day 4, they were treated daily for 7 days with a B1R antagonist (SSR240612, 10 mg/kg) or its vehicle. The surviving β-cells were measured by immunostaining. The expression of B1R, iNOS, TNF-α, macrophages, TCD4+, CGRP and TRPV1 was measured by Western blotting, qRT-PCR and im

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Putria, Sinta Julia Liona, Siti Rohani, Ertati Suarni, Yesi Astri, and Trisnawati Mundijo. "The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ." Biomedical Journal of Indonesia 11, no. 1 (2025): 60–67. https://doi.org/10.32539/bji.v11i1.236.

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Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models. Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110

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Ukah, Tobechukwu Kenneth, Alexis N. Cattin-Roy, Mindy M. Miller, and Habib Zaghouani. "Immune Modulation and Vascular Repair Sustain Pancreatic Beta Cell Regeneration To Reverse Late Stage Type 1 Diabetes." Journal of Immunology 200, no. 1_Supplement (2018): 176.8. http://dx.doi.org/10.4049/jimmunol.200.supp.176.8.

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Abstract Type 1 diabetes (T1D) is a chronic inflammatory disease which manifests when the pancreatic β-cells are destroyed by cells of the immune system. We have previously shown that antigen-specific therapy with Ig-GAD2, an Ig chimera carrying glutamic acid decarboxylase 206–220 sequence (GAD2), induces regeneration of β-cells and reverses T1D when intervention is made at the pre-diabetic stage. However, Ig-GAD2 could not reverse T1D when the treatment is made at the onset of disease (diabetic stage). Surprisingly, endothelial precursor cells (EPCs), alongside Ig-GAD2, sustain reversal of th

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Stiles, Bangyan L., Christine Kuralwalla-Martinez, Wei Guo та ін. "Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes". Molecular and Cellular Biology 26, № 7 (2006): 2772–81. http://dx.doi.org/10.1128/mcb.26.7.2772-2781.2006.

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ABSTRACT Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid phosphatase. PTEN inhibits the action of phosphatidylinositol-3-kinase and reduces the levels of phosphatidylinositol triphosphate, a crucial second messenger for cell proliferation and survival, as well as insulin signaling. In this study, we deleted Pten specifically in the insulin producing β cells during murine pancreatic development. Pten deletion leads to increased cell proliferation and decreased cell death, without significant alteration of β-cell differentiation. Consequently, the mutant pancreas gene

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Eluehike, Nkeiruka, and Iyere Osolase Onoagbe. "Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats." Avicenna Journal of Medical Biochemistry 8, no. 1 (2020): 15–20. http://dx.doi.org/10.34172/ajmb.2020.02.

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Background: There is a growing trend towards the use of medicinal plant that can prevent degeneration of pancreatic cells and regenerate islet cells in diabetes treatment Objectives: The possible effects of the extracts of Spondias mombin leaves on the regeneration of pancreatic beta cells in streptozotocin (STZ)-induced diabetic rats were determined in this study. Methods: Twenty-five male Wistar rats were randomly divided into 5 groups (A-E) including normal and diabetic rats. Aqueous and ethanol extracts of S. mombin were administered orally to diabetic rats in groups D and E for 12 weeks.

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Liu, Ye Qi, Peter W. Nevin та Jack L. Leahy. "β-Cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia". American Journal of Physiology-Endocrinology and Metabolism 279, № 1 (2000): E68—E73. http://dx.doi.org/10.1152/ajpendo.2000.279.1.e68.

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Islet β-cells are the regulatory element of the glucose homeostasis system. When functioning normally, they precisely counterbalance changes in insulin sensitivity or β-cell mass to preserve normoglycemia. This understanding seems counter to the dogma that β-cells are regulated by glycemia. We studied 60% pancreatectomy rats (Px) 4 wk postsurgery to elucidate the β-cell adaptive mechanisms. Nonfasting glycemia and insulinemia were identical in Px and sham-operated controls. There was partial regeneration of the excised β-cells in the Px rats, but it was limited in scope, with the pancreas β-ce

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Granata, Riccarda, Alessandra Baragli, Fabio Settanni, Francesca Scarlatti, and Ezio Ghigo. "Unraveling the role of the ghrelin gene peptides in the endocrine pancreas." Journal of Molecular Endocrinology 45, no. 3 (2010): 107–18. http://dx.doi.org/10.1677/jme-10-0019.

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The ghrelin gene peptides include acylated ghrelin (AG), unacylated ghrelin (UAG), and obestatin (Ob). AG, mainly produced by the stomach, exerts its central and peripheral effects through the GH secretagogue receptor type 1a (GHS-R1a). UAG, although devoid of GHS-R1a-binding affinity, is an active peptide, sharing with AG many effects through an unknown receptor. Ob was discovered as the G-protein-coupled receptor 39 (GPR39) ligand; however, its physiological actions remain unclear. The endocrine pancreas is necessary for glucose homeostasis maintenance. AG, UAG, and Ob are expressed in both

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Tian, Lei, Jie Gao, Jianqiang Hao та ін. "Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor". Endocrinology 151, № 7 (2010): 3049–60. http://dx.doi.org/10.1210/en.2010-0068.

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Inhibition of dipeptidyl peptidase IV (DPP-IV) activity by NVP-DPP728, a DPP-IV inhibitor, improves the therapeutic efficacy of glucagon-like peptide-1 (GLP-1). CD26 is a membrane-associated glycoprotein with DPP-IV activity and is expressed on lymphocytes. We investigated the effect of NVP-DPP728 on reversing new-onset diabetes in nonobese diabetic (NOD) mice and modulating the inflammatory response and stimulating β-cell regeneration. New-onset diabetic NOD mice were treated with NVP-DPP728 for 2, 4, and 6 wk. Blood glucose level was monitored. Regulatory T cells in thymus and secondary lymp

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Pasek, Raymond C., Jennifer C. Dunn, Joseph M. Elsakr, Mounika Aramandla, Anveetha R. Matta та Maureen Gannon. "Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice". American Journal of Physiology-Endocrinology and Metabolism 311, № 3 (2016): E564—E574. http://dx.doi.org/10.1152/ajpendo.00194.2016.

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During pregnancy, maternal β-cells undergo compensatory changes, including increased β-cell mass and enhanced glucose-stimulated insulin secretion. Failure of these adaptations to occur results in gestational diabetes mellitus. The secreted protein connective tissue growth factor (CTGF) is critical for normal β-cell development and promotes regeneration after partial β-cell ablation. During embryogenesis, CTGF is expressed in pancreatic ducts, vasculature, and β-cells. In adult pancreas, CTGF is expressed only in the vasculature. Here we show that pregnant mice with global Ctgf haploinsufficie

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M., Senthilnathan, Ramadevi A., Srinivas K., and Thangamani A. "Diabetes Mellitus: Can Stem Cells be the Answer?" Biotechnology Journal International 18, no. 4 (2017): 1–12. https://doi.org/10.9734/BJI/2017/34614.

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This review aims to enlighten the readers regarding the past, present and future of stem cells in the treatment of Diabetes. Diabetes is one of the leading causes of morbidity and mortality, affecting more than 415 million people worldwide. It is estimated that one in ten adults will have diabetes by 2030. Diabetes is mainly due to reduction in β-cell mass which are responsible for insulin production. Exogenous administration of insulin is having good impact on restoring glucose homeostasis, but it does not entirely control the minute-to-minute fluctuations in systemic blood glucose. Recently

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Khan, Anish Murtaja Alam, Nusrat Nabi, Gholamreza Abdi та ін. "Human Pancreatic β Cell Regenerative Therapy: Exploring the Role of Chicoric Acid as a Phytochemical Candidate". Journal of Phytopharmacology 13, № 2 (2024): 105–13. http://dx.doi.org/10.31254/phyto.2024.13204.

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Diabetes is a global health issue, impacting life expectancy and productivity. Pathogenesis of diabetes mellitus involves decreased functional beta cells, making beta cell replacement and regeneration a crucial area of research. However, current methods like whole pancreas transplant or stem cell-derived beta cells have limitations for diabetic patients. Exploring pharmacological approaches to stimulate regeneration of residual beta cells is valuable, as many diabetic patients retain some beta cells. Finding drugs that target and regenerate these cells effectively is a challenge, with no appro

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Wagner, Martin, Stefan Koschnick, Sven Beilke, Melanie Frey, Guido Adler та Roland M. Schmid. "Selective expansion of the β-cell compartment in the pancreas of keratinocyte growth factor transgenic mice". American Journal of Physiology-Gastrointestinal and Liver Physiology 294, № 5 (2008): G1139—G1147. http://dx.doi.org/10.1152/ajpgi.00338.2007.

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Epithelial-mesenchymal interactions are essential for growth, differentiation, and regeneration of exocrine and endocrine cells in the pancreas. The keratinocyte growth factor (KGF) is derived from mesenchyme and has been shown to promote epithelial cell differentiation and proliferation in a paracrine fashion. Here, we have examined the effect of ectopic expression of KGF on pancreatic differentiation and proliferation in transgenic mice by using the proximal elastase promoter. KGF transgenic mice were generated following standard procedures and analyzed by histology, morphometry, immunohisto

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Lu, Li, Li Zhitao, Cui Nannan та ін. "Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation". Stem Cells International 2022 (27 березня 2022): 1–18. http://dx.doi.org/10.1155/2022/1172795.

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β cell dysfunction is the leading cause of diabetes. Adult β cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal β cells are insensitive to glucose and are functionally immature. However, how β cells mature and acquire robust GSIS is not fully understood. Here, we explored the potential regulatory proteins of β cell maturation process and the capacity for GSIS. Combined with the data from public databases, we found that the gene expression of Mitofusin2 (Mfn2) showed an increasing trend from mouse neonatal β cells to mature β cells. Moreover, its protein

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Shimada, K., T. Ito, G. Miao та ін. "Regeneration of β Cells in the Native Pancreata After Syngeneic and Allogeneic Pancreas Transplantations in Spontaneously Type 2 Diabetic Torii Rats". Transplantation Proceedings 40, № 2 (2008): 438–40. http://dx.doi.org/10.1016/j.transproceed.2008.01.019.

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Omoboyowa, D. A., F. O. Afolabi, and T. C. Aribigbola. "Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats." Biomedical Research and Therapy 5, no. 7 (2018): 2440–54. http://dx.doi.org/10.15419/bmrat.v5i7.456.

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Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate.

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Manam, Vishnu Kiran, and Subbaiah Murugesan. "Anti-diabetic Efficacy of Silver Nanoparticles Biosynthe-sized from Marine Red Seaweed Halymenia porphyroides Boergesen on Alloxan Stimulated Hyperglycemic Activity in Rats." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 5 (2021): 5639–46. http://dx.doi.org/10.37285/ijpsn.2021.14.5.8.

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The assessment of silver nanoparticles biosynthesized and characterized using UV-Spec, FTIR, XRD, TGA, SEM, TEM from marine red seaweed Halymenia porphyroides have been evaluated for its anti-hyperglycemic activity in vivo. The anti-diabetic efficacy of the biosynthesized silver nanoparticles from marine red seaweed Halymenia porphyroides was studied by chemically inducing diabetes in the experimental Wistar albino rats through Alloxan monohydrate, which ultimately results in hyperglycemia at a dosage of 50 mg/kg body weight given orally for about 28 days. The outcome of the results was estima

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Al-Adsani, Amani M., Anoud N. Al-Otaibi, Sahar A. Barhoush, Khaled K. Al-Qattan, and Suzanne A. Al-Bustan. "Expression Profiling of Pdx1, Ngn3, and MafA in the Liver and Pancreas of Recovering Streptozotocin-Induced Diabetic Rats." Genes 13, no. 9 (2022): 1625. http://dx.doi.org/10.3390/genes13091625.

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Studies in animal diabetic models have demonstrated the possibility of islet regeneration through treatment with natural extracts, such as Allium sativum (garlic). This study aimed to investigate the effect of garlic extract (GE) on the expression of three genes (Ngn3, Pdx1, and MafA) in the pancreas and liver of diabetic rats. Thirty-two rats were divided into two groups, streptozotocin (STZ)-induced diabetic rats (n = 16) and healthy rats (n = 16). Both groups were subdivided into GE-treated (n = 8), and those administered 0.9% normal saline (NS) (n = 8) for 1 week (n = 4) and 8 weeks (n = 4

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Albadr, Abrar, and Nazar S. Haddad. "Pancreatic Stone Protein/ regenerating Protein (PSP/reg) as a Biochemical Marker for prediction of Microvascular Complications of Type 2 Diabetes Mellitus." AL-Kindy College Medical Journal 19, no. 2 (2023): 66–71. http://dx.doi.org/10.47723/kcmj.v19i2.966.

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Background: Type 2 diabetes mellitus (T2DM) characterized by insulin resistance (IR) and progressive decline in functional beta (β) cell mass partially due to increased β cell apoptosis rate. Pancreatic stone protein /regenerating protein (PSP/reg) is produced mainly by the pancreas and elevated drastically during pancreatic disorder. Beta cells are experiencing apoptosis that stimulate the expression of PSP/reg gene in surviving neighboring cells, and that PSP/reg protein is subsequently secreted from these cells which could play a role in their regeneration. Objectives: To analyze serum leve

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Kucia, Magda, Krzysztof Oldak, Mariusz Z. Ratajczak, Janina Ratajczak, and Zygmunt Pojda. "Percoll Gradient Separation of Cord Blood Mononuclear Cells Reveals the Presence of a Novel Population of CXCR4+ Oct-4+ Small Embryonic-Like Stem Cells." Blood 106, no. 11 (2005): 1069. http://dx.doi.org/10.1182/blood.v106.11.1069.1069.

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Abstract Cord blood (CB) mononuclear cells (MNC) were demonstrated to contribute to organ/tissue regeneration, however, the identity of the specific cell type(s) involved remains unknown. Recently, it had been identified in adult bone marrow (BM) a mobile, SDF-1-, HGF/SF- and LIF-responsive population of CXCR4+ non-hematopoietic MNC that expresses markers (RQ-PCR, immunhistochemistry) of early pluripotent/tissue committed stem cells (TCSC) for skeletal muscles, heart, neural tissue, liver, pancreas, epidermis and intestinal epithelium (Leukemia2004:18;29–40). We hypothesized that a similar pop

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Olenovych, O., T. Boychuk, I. Davydenko, and O. Davydenko. "HISTOMORPHOLOGICAL PECULIARITIES OF THE PANCREATIC PARENCHYMA IN RATS WITH ALLOXAN-INDUCED DIABETES OF DIFFERENT DURATION." Neonatology, Surgery and Perinatal Medicine 14, no. 2(52) (2024): 100–107. http://dx.doi.org/10.24061/2413-4260.xiv.2.52.2024.15.

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The study of pathohistological and morphofunctional changes in the endocrine pancreas is an integral part of experimental diabetology, which allows obtaining a signifi cant amount of information on various aspects of the etiology and pathogenesis of diabetes and its complications using experimental animal models. Aim of the study was to conduct a comprehensive evaluation of histostructure peculiarities of the pancreas and the reparativepotential of the aff ected pancreatic islets of Langerhans in rats with alloxan- induced experimental diabetes mellitus (EDM) of diff erent duration.Materials a

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Abd El Latif, Amira, Badr El Said El Bialy, Hamada Dahi Mahboub та Mabrouk Attia Abd Eldaim. "Moringa oleiferaleaf extract ameliorates alloxan-induced diabetes in rats by regeneration of β cells and reduction of pyruvate carboxylase expression". Biochemistry and Cell Biology 92, № 5 (2014): 413–19. http://dx.doi.org/10.1139/bcb-2014-0081.

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Moringa oleifera Lam. contains many active ingredients with nutritional and medicinal values. It is commonly used in folk medicine as an antidiabetic agent. The present study was designed to investigate how an aqueous extract from the leaves of M. oleifera reveals hypoglycemia in diabetic rats. M. oleifera leaf extract counteracted the alloxan-induced diabetic effects in rats as it normalized the elevated serum levels of glucose, triglycerides, cholesterol, and malondialdehyde, and normalized mRNA expression of the gluconeogenic enzyme pyruvate carboxylase in hepatic tissues. It also increased

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Adepoju, Feyisayo O., Ksenia V. Sokolova, Irina F. Gette, et al. "Protective Effect of Betulin on Streptozotocin–Nicotinamide-Induced Diabetes in Female Rats." International Journal of Molecular Sciences 25, no. 4 (2024): 2166. http://dx.doi.org/10.3390/ijms25042166.

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Type 2 diabetes is characterized by hyperglycemia and a relative loss of β–cell function. Our research investigated the antidiabetic potential of betulin, a pentacyclic triterpenoid found primarily in birch bark and, intriguingly, in a few marine organisms. Betulin has been shown to possess diverse biological activities, including antioxidant and antidiabetic activities; however, no studies have fully explored the effects of betulin on the pancreas and pancreatic islets. In this study, we investigated the effect of betulin on streptozotocin–nicotinamide (STZ)-induced diabetes in female Wistar

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Gupta, P. P., J. Haider, R. P. Yadav, and U. Pal. "Preclinical evaluation of antidiabetic activity of poly herbal plant extract in streptozotocin induced diabetic rats." Journal of Phytopharmacology 5, no. 2 (2016): 45–49. http://dx.doi.org/10.31254/phyto.2016.5202.

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Objective: To study and compare the effect of Poly herbal plant extract (PHPE) with Glibenclamide (GL) on various parameters in Streptozotocin (STZ) induced diabetic rats. Methods: Diabetes was induced by combining High Fat-diet and injecting low dose Streptozotocin (35 mg/kg body wt.) to Sprague-dawley rats. Diabetic rats were treated with chloroform leaf extract of Azadirachta indica, aqueous leaf extract of Bougainvillea spectabilis and ethanolic seed extract of Trigonella foenum graecum combined in ratio of 1:2:3 respectively at dose of 600 mg/kg body weight by oral gavaging for 28 days. T

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Barrera Roa, Jose, Gabiela Sanchez Tortolero, and Emanuele Gonzalez. "Trefoil factor 3 (TFF3) expression is regulated by insulin and glucose." Journal of Health Sciences 3, no. 1 (2013): 1–12. http://dx.doi.org/10.17532/jhsci.2013.26.

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Introduction: Trefoil factors are effector molecules in gastrointestinal tract physiology. They are classified into three groups: the gastric peptides (TFF1), spasmolytic peptide (TFF2) and intestinal trefoil factor (TFF3). Previous studies have shown that trefoil factors are located and expressed in human endocrine pancreas suggesting that TFF3 play a role in: a) pancreatic cells migration, b) β-cell mitosis, and c) pancreatic cells regeneration. We speculated that the presence of TFF3 in pancreas, could be associated to a possible regulation mechanism by insulin and glucose. To date, there a

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Abdul, Mughni, Chemy Wiryawan, Reza Tri Sutrisno, Vito Mahendra, and Dimas Erlangga. "Effect of Sleeve Gastrectomy With Pancreatic Omentoplasty On Pancreatic Vegf Intensity In Non-Obesity Diabetes Mellitus Rats." Eduvest - Journal of Universal Studies 2, no. 12 (2022): 2734–42. http://dx.doi.org/10.59188/eduvest.v2i12.696.

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Diabetes mellitus is one of the most common non-communicable diseases that that is still growing today especially diabetes mellitus type 2 (DMT2). Diabetes in non-obese patients is an important problem to solve because it tends to be worse than DM in obese patients. Chronic hyperglycemia can damage body tissues through several mechanisms like polyol pathway, hexosamine pathway, activation of protein kinase C (PKC) and advance glycation end products (AGEs). This pathway can damage the pancreas so that insulin cannot be secreted and worsen the condition of diabetes. Sleeve gastrectomy procedure

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Sentoso, Joko Wibowo, Agung Putra, and Henky Agung Nugroho. "The Role of Mesenchymal Stem Cells Secretome in Regeneration of Thyroid Tissue Damage after Thyroid Lobectomy: A Literature Review." Journal of Cancer and Tumor International 14, no. 2 (2024): 14–20. http://dx.doi.org/10.9734/jcti/2024/v14i2252.

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Mesenchymal Stem Cells (MSC) are a type of stem cell that is multipotent and originates from the mesoderm and ectoderm at an early stage of development and can differentiate into: 1. Ectodermal derivatives such as: neurons, keratocytes and keratinocytes; 2. Endodermal derivatives such as: hepatocytes and pancreatic β cells. MSCs were first discovered in the bone marrow, but in recent research they have been found in many other body tissues, such as the lungs, pancreas, liver, adipose tissue, synovial tissue, muscles, bones, amniotic fluid and umbilical cord blood. MSCs vary in content, accessi

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Moustafa, Enas M., Fatma S. M. Moawed, and Gehan R. Abdel-Hamid. "Icariin Promote Stem Cells Regeneration and Repair Acinar Cells in L-arginine / Radiation -Inducing Chronic Pancreatitis in Rats." Dose-Response 18, no. 4 (2020): 155932582097081. http://dx.doi.org/10.1177/1559325820970810.

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Objective: Chronic Pancreatitis (CP) is a multifactorial disease. It was characterized by severe inflammation and acinar cell destruction. Thus, the present study was initiated to evaluating the ability of bone marrow-based mesenchymal stem cell (MSCs) combined with Icariin to restore and regenerate acinar cells in the pancreas of rats suffering chronic pancreatitis. Methods: Chronic pancreatitis was induced in rats via both L-arginine plus radiation, repeated L-arginine injection (2.5g/Kg body-weight, 1, 4,7,10,13,16,19 days), then, on day 21, rats were exposed to a single dose of gamma-radia

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Altabas, Velimir, and Tomislav Bulum. "Current Challenges in Pancreas and Islet Transplantation: A Scoping Review." Biomedicines 12, no. 12 (2024): 2853. https://doi.org/10.3390/biomedicines12122853.

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Type 1 diabetes mellitus is an autoimmune condition characterized by the destruction of pancreatic β-cells, necessitating insulin therapy to prevent life-threatening complications such as diabetic ketoacidosis. Despite advancements in glucose monitoring and pharmacological treatments, managing this disease remains challenging, often leading to long-term complications and psychological burdens, including diabetes distress. Advanced treatment options, such as whole-pancreas transplantation and islet transplantation, aim to restore insulin production and improve glucose control in selected patien

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Iftikhar, Asra, Bilal Aslam, Maryam Iftikhar, et al. "Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway." Oxidative Medicine and Cellular Longevity 2020 (March 17, 2020): 1–14. http://dx.doi.org/10.1155/2020/9020219.

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Caesalpinia bonduc has been used in herbal medicines for the treatment of a wide range of diseases from decades. The present study has explored the remedial potential and underlying mechanism of polyphenol extract of Caesalpinia bonduc in alloxanized diabetic rats. HPLC/MS analysis confirmed the presence of phenolics in considerable concentrations in Caesalpinia bonduc extract. Administration of different doses (250 and 500 mg/kg) of CPP extract to hyperglycemic rats for 8 weeks restored blood and serum glucose, insulin, glycosylated hemoglobin, leptin, amylin, and carbohydrate metabolizing en

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Wookey, Peter J., Thomas A. Lutz, and Sof Andrikopoulos. "Amylin in the Periphery II: An Updated Mini-Review." Scientific World JOURNAL 6 (2006): 1642–55. http://dx.doi.org/10.1100/tsw.2006.263.

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Amylin is a polypeptide that is cosecreted with insulin from the β cells of the pancreas. Therefore, in states of diabetes in which the β-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated.While the soluble monomeric form of amylin acts as a hormone that alters physiological responses related to feeding and acts as a specific growth factor, there has been renewed interest in the less-soluble oligomeric and insoluble polymeric forms of human (also monkey and cat) amylin that may contribute to the establishment of a pathophysiological pathw

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