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Journal articles on the topic 'Pancreas Histoarchitecture'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Anyakudo, Magnus Michael Chukwudike, Naomi Tinuola Omogbehin, and Olorunsola Israel Adeyomoye. "Beneficial Impacts of Solanum aethiopicum L. in Diabetes Control." International Journal of Nutrition 7, no. 1 (2022): 30–40. http://dx.doi.org/10.14302/issn.2379-7835.ijn-22-4170.

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Garden egg nutritional values are numerous. However, few nutritional and epidemiological data exist on the impacts of garden egg consumption on diabetes control. In this experimentally-control designed nutritional study, the effects of scarlet garden egg species (Solanum aethiopicum L.) on lipoglycemic profile, weight control and, pancreas histoarchitecture in diabetic male Wistar rats were examined. Twenty-One adult male Wistar rats inducted with diabetes were randomly categorized into three groups (n = 7, each): Diabetic control (DC); Diabetic treated with aqueous extract of garden egg (DEE)

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2

Lal, Kanwar, Ashok Purohit, and Heera Ram. "GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS ." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 292. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.17997.

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Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undul

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3

Al-Saffar, F. J., and Riyadh Hameed Nasif. "Histoarchitecture and histochemical study of the exocrine pancreas of the adult guinea pigs (Cavia porcellus)." Veterinary Medicine and Public Health Journal 1, no. 3 (2020): 85–90. http://dx.doi.org/10.31559/vmph2020.1.3.3.

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4

Abou Khalil, Nasser S., Alaa S. Abou-Elhamd, Salwa I. A. Wasfy, Ibtisam M. H. El Mileegy, Mohamed Y. Hamed, and Hussein M. Ageely. "Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats." Journal of Diabetes Research 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/8408326.

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Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts ofBalanites aegyptiacaandPetroselinum sativumextracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. F

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5

Tizhe, Emmanuel, Najume Ibrahim, Mohammed Fatihu, Suleiman Ambali, Ikechukwu Igbokwe, and Ussa Tizhe. "Pancreatic function and histoarchitecture in Wistar rats following chronic exposure to Bushfire®: the mitigating role of zinc." Journal of International Medical Research 46, no. 8 (2018): 3296–305. http://dx.doi.org/10.1177/0300060518778640.

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Objectives To assess the toxicopathologic effects of chronic exposure to the glyphosate-based herbicide Bushfire® on the pancreas of Wistar rats and the protective role of zinc. Methods We exposed the rats to daily doses of 14.4 to 750 mg/kg body weight of the glyphosate-based herbicide Bushfire® and to 50 or 100 mg/kg zinc, and measured blood glucose levels and serum insulin levels. Tissue samples were evaluated for histopathological alterations. Results Levels of both blood glucose and serum insulin increased in glyphosate-exposed rats, and moderate to severe degenerative changes were observ

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6

Bradbery, A. N., J. A. Coverdale, C. J. Hartz, et al. "Effect of maternal overnutrition on predisposition to insulin resistance in the foal: Maternal parameters and foal pancreas histoarchitecture." Animal Reproduction Science 227 (April 2021): 106720. http://dx.doi.org/10.1016/j.anireprosci.2021.106720.

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7

Peña-Corona, Sheila I., Dinorah Vargas-Estrada, Juan I. Chávez-Corona та ін. "Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats". Toxics 11, № 7 (2023): 626. http://dx.doi.org/10.3390/toxics11070626.

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This study investigated whether the coadministration of vitamin E (VitE) diminishes the harmful effects provoked by plasticizer bisphenol S (BPS) in the serum metabolites related to hepatic and renal metabolism, as well as the endocrine pancreatic function in diabetic male Wistar rats. Rats were divided into five groups (n = 5–6); the first group was healthy rats (Ctrl group). The other four groups were diabetic rats induced with 45 mg/kg bw of streptozotocin: Ctrl-D (diabetic control); VitE-D (100 mg/kg bw/d of VitE); BPS-D (100 mg/kg bw/d of BPS); The animals from the VitE + BPS-D group were

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8

Al-Saffar, F., and Riyadh Nasif. "Histoarchitecture of Islet’s of Langerhans and Their Related Hormones Analysis in the Pancreas of Adult Guinea Pig (Cavia porcellus)." Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry 11, no. 2 (2019): 33–42. http://dx.doi.org/10.21608/eajbsd.2019.57991.

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9

Marcus Durojaye, Ayoola, Oluwagbemi Moyinoluwa, Odediran Akintunde Samuel, Oladoja Farouk Adedeji, and Kasumu Oluwabusayo Emmanuel. "Evaluation of the Antihyperglycaemic Activities, Safety and Phytochemical Profile of Celtis zenkeri Engl." Archives of Pharmacy and Pharmaceutical Sciences 7, no. 1 (2023): 036–44. http://dx.doi.org/10.29328/journal.apps.1001042.

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Objective: The study evaluated the hyperglycaemia-lowering effects, safety, and phytochemical profile of Celtis zenkeri leaf extract in order to justify its antidiabetic folkloric usage. Methods: Modified OECD test guidelines were used to assess its acute and sub-acute toxicity while its effect on blood parameters such as blood glucose, and haematological and biochemical levels were evaluated using appropriate assays. Both in vitro and in vivo antihyperglycaemic assays were used for the antidiabetic studies while histology of the pancreas, liver, and kidney of the rats was examined after treat

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10

Alsailawi, H. A., Rawaa T. Alasadi, Sharara Fadhil Abbood, et al. "Effect of zinc sulfate on biochemical parameters, histopathological, histochemical and immunological in male <em>albino</em> rats." Multidisciplinary Science Journal 6, no. 12 (2024): 2024219. http://dx.doi.org/10.31893/multiscience.2024219.

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All tissues contain zinc, the most prevalent intracellular trace element. Muscle and bone contain the highest amounts of zinc. A subchronic toxicity study was carried out to determine the effects of overdose from zinc sulphate induced biochemical and histopathological changes in the rats' liver, stomach, pancreas, kidney, brain, and spleen. Forty male albino rats were used in this study. Twenty, forty, and sixty mg/kg of zinc sulphate were given to the second group during the six-week study period, while the first group served as the control. Samples of the liver, kidney, and serum were collec

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11

Alabi, Toyin Dorcas, Nicole L. Brooks, and Oluwafemi O. Oguntibeju. "Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes." Plants 10, no. 2 (2021): 300. http://dx.doi.org/10.3390/plants10020300.

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Kidney disease in diabetes is one of the common microvascular complications of diabetes mellitus implicated in end-stage renal failure. This study explored the ability of Anchomanes difformis to ameliorate kidney and pancreatic damage in type 2 diabetes mellitus using male Wistar rats. Two weeks of fructose (10%) administration followed by streptozotocin (40 mg/kg) were used to induce type 2 diabetes. Leaf extract (aqueous) of Anchomanes difformis (200 mg and 400 mg/kgBW) was administered orally for six weeks. Body weights were monitored, urea and creatinine were measured. Interleukins (IL)-1β

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12

Mandlik, Rahul V., Suresh R. Naik, Sandip Zine, Hemen Ved, and Gaurav Doshi. "Antidiabetic Activity of Caulerpa racemosa: Role of Proinflammatory Mediators, Oxidative Stress, and Other Biomarkers." Planta Medica International Open 9, no. 01 (2022): e60-e71. http://dx.doi.org/10.1055/a-1712-8178.

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AbstractA marine alga, Caulerpa racemose (seaweed), exhibits few biological activities, such as antinociceptive/anti-inflammatory, antitumor, and growth regulator. This study aimed to determine the antidiabetic activity of this seaweed. High-performance thin-layer chromatography of C. racemosa ethanolic extract was performed to identify its active constituents. Antidiabetic activity of C. racemosa ethanolic extract (100 and 200 mg/kg) was evaluated using various biochemical paradigms against glipizide (5 mg/kg) in a streptozotocin-induced diabetes rat model. High-performance thin-layer chromat

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13

Sarkar, Deotima, Arijit Chakraborty, Adipa Saha, and Amar K. Chandra. "Iodine in excess in the alterations of carbohydrate and lipid metabolic pattern as well as histomorphometric changes in associated organs." Journal of Basic and Clinical Physiology and Pharmacology 29, no. 6 (2018): 631–43. http://dx.doi.org/10.1515/jbcpp-2017-0204.

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Abstract Background Iodine is a nonpareil constituent of thyroid hormones (THs) and a prime regulator of thyroid gland functioning. Although essential at recommended levels for the prevention of iodine deficiency disorders (IDDs), exposure to excess iodine reportedly causes hypothyroidism, hyperthyroidism, and several other emerging deleterious impacts. The objective of the present study is to explore the influence of excess iodide exposure on carbohydrate and lipid metabolism along with the histoarchitecture of certain associated organs such as the pancreas, liver, kidney, and skeletal and ca

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14

Paudel, YN, MR Ali, S. Bawa та ін. "Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats". Human & Experimental Toxicology 37, № 2 (2017): 163–74. http://dx.doi.org/10.1177/0960327117692133.

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4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitivity, oxidative stress, and inflammatory mediators were evaluated in streptozotocin (STZ)-induced neonatal models of non-insulin-dependent diabetes mellitus (NIDDM) rats where NIDDM was induced in neonatal pups with single intraperitoneal injection of STZ (100 mg/kg). The effect of BAC (10 and 20 mg/kg, p.o.) for 3 weeks was evaluated by the determination of

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15

Velmani, Krishnasamy, and Muruhan Sridevi. "In vivo assessment of Antidiabetic Activity in Streptozotocin (STZ) induced Diabetes in Albino Rats for isolated compound (E, 7R, 11R) - 3,7,11,15- tetramethyl hexadec-2- en-1-ol isolated from Waltheria indica Linn." Research Journal of Biotechnology 20, no. 3 (2025): 54–63. https://doi.org/10.25303/203rjbt054063.

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The growing global incidence of diabetes mellitus is a major problem in both developed and developing countries and the limitations associated with currently available treatments have shifted researchers' focus to naturopathy. Herbal plants have been utilised for the treatment of diabetes since ancient times as they are less poisonous and have fewer adverse effects than synthetic ones. We isolated and purified two novel chemicals (Phytol and 2- Methyl hexadecan-1-ol) from Waltherica indica hydroalcoholic extract in prior investigations. The goal of this work was to assess the in vivo antidiabe

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16

Oyesola, Olusoji. "Evaluation of the effect of antibiotics, anti-inflammatory agent, and monoclonal antibody on the gastrointestinal tract in a rat model of acetic acid-induced ulcerative colitis." Journal of Current Biomedical Research 4, no. 5 (2024): 1836–57. https://doi.org/10.54117/jcbr.v4i5.5.

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by gut pathology and impaired gut function. This study aimed to evaluate the efficacy of antibiotic, anti-inflammatory, and monoclonal antibody therapies on gut pathology in a rat model of acetic acid-induced UC. Fifty Adult Male Sprague-Dawley rats were divided into five groups of ten rats each, the animals were allowed to acclimatize for a period of 2 weeks. The induction of the ulcerative colitis was done according to the method described by Al-Rejaie et al., (2013), after 24 hours fast, 2 ml of 4% acetic acid sol

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17

Gogoi, Neelutpal, and Biman Bhuyan. "IN VIVO ANTI-DIABETIC ACTIVITY EVALUATION OF THE BARK OF CASCABELA THEVETIA L. IN STREPTOZOTOCIN INDUCED DIABETIC RATS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 6 (2017): 48. http://dx.doi.org/10.22159/ijpps.2017v9i6.17200.

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Objective: In this study, the plant Cascabela thevetia L. was selected based on ethnomedicinal documentation reports for evaluation of the antidiabetic activity. The aim of this study was to carry out acute toxicity study and in vivo evaluation of antidiabetic activity in an animal model.Methods: Firstly direct extraction of the dried bark powder was done with methanol using soxhlet apparatus. After collecting the extract, acute toxicity study was performed according to OECD (Organization for Economic Cooperation and Development) guideline 425. For in vivo evaluation of antidiabetic activity,

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18

Elijah, Arayombo Babatunde, Viskasari Pintoko Kalanjati, Ofusori David Adesanya, et al. "Histological and Histomorphometric Effects of Ethyl Acetate Fraction of Lycopene on the Liver and Pancreas of Experimentally-Induced Diabetic Wistar Rats." Recent Advances in Clinical Trials 4, no. 1 (2024). https://doi.org/10.33425/2771-9057.1036.

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Objectives: The aim of the study was to assess the effects of ethyl acetate fraction of lycopene (EAFL) on the histoarchitecture and histomorphometry of liver and pancreas of experimentally-induced diabetic Wistar rats. Materials and Methods: Sixty adult male Wistar rats weighing between 180 and 200g were used for this study. The animals were kept in the animal holding of the department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile-Ife. They were fed on high fat rat diet for 4 weeks and given water ad libitum. The animals were given humane care according to the guidelines of Hea

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19

Demyashkin, Grigory, Tatyana Dubovaya, Dali Ugurchieva, Matvey Vadyukhin, Pinara Akhmedova, and Valeria Simagina. "Morphofunctional characteristics of the pancreas after administration of N-acetylcysteine in an acute post-radiation pancreatitis model." Morphology, December 22, 2023. http://dx.doi.org/10.17816/morph.623166.

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BACKGROUND: The development of effective methods of non-drug and drug protection of humans and animals from the effects of ionizing radiation remains relevant. It is necessary to conduct a morphofunctional assessment of changes in the pancreatic parenchyma and identify the degree of radiosensitization of acinocytes and insulocytes outside the tumor, as well as during electron therapy of cancer of neighboring organs, such as the colon, stomach, etc. AIM: morphological assessment of the pancreas after administration of N-acetylcysteine in a model of acute radiation-induced pancreatitis.&#x

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20

Anyakudo, M., and A. Olanubi. "Beneficial Effects of Moderate Intake of Red Wine on Glycemic Control, Lipid Profile and Pancreas Histoarchitecture in Diabetic Rats Fed on High Carbohydrate Diet." July 19, 2016. https://doi.org/10.19070/2326-3350-1600056.

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Moderate alcohol consumption has been linked to improved cardiovascular and total mortality rates. However, the riskbenefit balance is controversial among moderate drinkers where evidence of type 2 diabetes was reported to be less prevalent. This experimentally-controlled designed study aimed to determine the effects of moderate red wine consumption on body anthropometry, glycemic and lipid profiles and pancreatic tissue histology in diabetic rats. Twenty eight male Wistar rats each weighing ≥ 200g were randomly categorized into four experimental groups (n=7, each): Normal control fed with sta

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21

M, Anyakudo, and Olanubi A. "Beneficial Effects of Moderate Intake of Red Wine on Glycemic Control, Lipid Profile and Pancreas Histoarchitecture in Diabetic Rats Fed on High Carbohydrate Diet." International Journal of Food Science, Nutrition and Dietetics, July 19, 2016, 313–18. http://dx.doi.org/10.19070/2326-3350-1600056.

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22

"Fractions of Lawsonia inermis Linn leaves reversed the damage caused to major organs involved in diabetic complications by improving their histomorphological appearance in diabetic Wistar rat model." Journal of Sustainable Veterinary and Allied Sciences, June 15, 2022, 33–40. http://dx.doi.org/10.54328/covm/josvas.2022.045.

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Diabetes mellitus (DM) is clinically known as diverse sets of biochemical syndromes with a basic symptom of glucose intolerance and is a major cause of morbidity and mortality worldwide. Diabetes mellitus exclusively disrupts glucose metabolism in various tissues and organs leading to complications such as retinopathy, nephropathy and brain micro-infarcts. This study investigated the positive modulatory effect of Lawsonia inermis Linn leaves on major organs involved in diabetic complications in Wister rats experimentally induced by type 1 diabetes using streptozocine. Lawsonia inermis leaves w

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23

"Fractions of Lawsonia inermis Linn leaves improved the histomorphological appearance of major organs involved in diabetic complications." Journal of Sustainable Veterinary and Allied Sciences, March 31, 2022, 34–40. http://dx.doi.org/10.54328/covm.josvas.2022.045.

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Diabetes mellitus (DM) is clinically known as diverse sets of biochemical syndromes with a basic symptom of glucose intolerance and is a major cause of morbidity and mortality worldwide. Diabetes mellitus exclusively disrupts glucose metabolism in various tissues and organs leading to complications such as retinopathy, nephropathy and brain micro-infarcts. This study investigated the positive modulatory effect of Lawsonia inermis Linn leaves on major organs involved in diabetic complications in Wister rats experimentally induced by type 1 diabetes using streptozocine. Lawsonia inermis leaves w

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24

ADEOYE, Olufunso B., Abolape A. IYANDA, Michael O. DANIYAN, et al. "ANTI-DYSLIPIDAEMIA AND CARDIO-PROTECTIVE EFFECTS OF NIGERIAN BITTER HONEY IN STREPTOZOTOCIN INDUCED DIABETIC RATS." Universal Journal of Pharmaceutical Research, May 15, 2023. http://dx.doi.org/10.22270/ujpr.v8i2.920.

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Background and Aim: Chronic hyperglycemia, oxidative stress, and dyslipidemia usually predispose to cardiac aberrations. Certain honey samples have been reported to worsen glycemic control or proven to be cardiotoxic. The study sought to elucidate the roles of Nigerian bitter honey in experimental diabetes. Experimental Procedures: Diabetes was induced in adult female Wistar rats (90–110g) by single administration of streptozotocin (65 mg/kg body weight, i.p.). Rats were randomly allocated into six groups (n= 8). Bitter honey (50 mg/kg) and metformin (100 mg/kg) were orally administered daily

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