Academic literature on the topic 'Pancreatic Adenocarc'

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Journal articles on the topic "Pancreatic Adenocarc"

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Srinivasalu, Vijay Kumar, Narayana Subramaniam, Manjula Das, and Sujan Kumar Dhar. "Lipocalin 2 – Devil or Angel? A pan cancer study." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15609-e15609. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15609.

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e15609 Background: Lipocalin2 (LCN2, also known as neutrophil gelatinase-associated lipocalin), is a protein that in humans is encoded by the LCN2 gene. It’s abnormal expression serves critical roles in the EMT transition process, angiogenesis, cell migration and invasion in many cancers. We aim to study the expression of LCN2 in tumours with respect to normal and its association with survival in multiple forms of cancer. Methods: On analysis of 23 TCGA datasets containing gene expression data for both tumour and adjacent normal samples, normalized RNAseq RSEM values of LCN2 were compared and
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Martinez, Brandon Keith, Niraj K. Gupta, Vincent Flanders, Kannan Natarajan, Marc Underhill, and Jeff Cooke. "Safety and feasibility of yttrium-90 (Y-90) treatment for primary and metastatic liver tumors at a community hospital." Journal of Clinical Oncology 31, no. 15_suppl (2013): e14698-e14698. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14698.

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e14698 Background: Y-90 microspheres administered via hepatic artery is being increasingly utilized in the management of pri/metastatic liver cancers. We report safety/efficacy data on Y-90 therapy performed at a community hospital treating high volume of cancer patients. Methods: Multi-disciplinary tumor conferences were used for appropriate patient selection and pts. were seen on referral in the I/R clinic. Liver/tumor volume calculations were performed on pre-treatment imaging. Prescribed activity was calculated by BSA methods. Fractional tumor, liver-flow characteristics and lung shunt fra
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Baird, Richard D., Sophie Papa, Nicola Cresti, et al. "A phase I study of S-222611 an oral reversible dual inhibitor of EGFR and HER2, in patients with solid tumors." Journal of Clinical Oncology 30, no. 15_suppl (2012): 3100. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3100.

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3100 Background: S-222611 is a novel oral, potent, reversible tyrosine kinase inhibitor with antiproliferative activity in human tumor cell lines expressing EGFR and/or HER2 in vitro and in mouse xenograft models. We conducted the first study in patients (pts) with solid tumors expressing EGFR or HER2. Methods: Daily oral doses of S-222611 were escalated in successive cohorts from 100 mg to a maximum 1600 mg, using a 3 + 3 design. Full plasma pharmacokinetic (PK) profiles were obtained in all pts for 7 days after a single dose on Day 1 and for 24 h following 21 days of once daily dosing (Cycle
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Wang, Congcong, Jianping Guo, Xiaoyang Zhao, et al. "Identification of Hub Genes in Pancreatic Ductal Adenocarci-noma Using Bioinformatics Analysis." Iranian Journal of Public Health, October 26, 2021. http://dx.doi.org/10.18502/ijph.v50i11.7578.

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Background: To address the biomarkers that correlated with the prognosis of patients with PDCA using bioinformatics analysis.
 Methods: The raw data of genes were obtained from the Gene Expression Omnibus. We screened differently expressed genes (DEGs) by Rstudio. Database for Annotation,Visualization and Intergrated Discovery was used to investigate their biological function by Gene Ontology(GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. Protein-protein interaction of these DEGs were analyzed based on the Search Tool for the Retrieval of Interacting Genes database (STRING) and visu
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Dissertations / Theses on the topic "Pancreatic Adenocarc"

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ROVIELLO, GIANDOMENICO. "Tumour Infiltrating Lymphocytes and Immune-Related Genes as Predictors of Outcome in Pancreatic Adenocarcinoma." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2961014.

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Background: Pancreatic Carcinoma (PC) is a lethal disease with a poor prognosis. Pancreatic Carcinoma is characterized by a desmoplastic, highly heterogeneous and immune-suppressive microenvironment that hinders antitumour immunity. The aim of this study is to investigate the correlation between PC patient prognosis and the presence of tumour infiltrating lymphocytes and expression of 521 immune system genes. Materials and Method: Fresh PC specimens were obtained from patients (n=12) undergoing surgical resection at the Department of Medical, Surgical & Health Sciences, Cattinara Teaching Hos
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