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Journal articles on the topic 'Pancreatic malignancy'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Shaikh, Oseen Hajilal, Julia Sunil, Sagar Prakash, Chellappa Vijaykumar, and Uday Shamrao Kumbhar. "Isolated pancreatic tuberculosis masquerading pancreatic malignancy." BMJ Case Reports 16, no. 7 (2023): e254250. http://dx.doi.org/10.1136/bcr-2022-254250.

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Pancreatic tuberculosis is the rarest form of abdominal and extrapulmonary tuberculosis. We present a patient in his 40s who presented with pain abdomen and a fever. On examination, the patient had mild jaundice and right hypochondriac tenderness. Blood investigation was suggestive of obstructive jaundice. Imaging studies were representative of pancreatic head lesion, causing mild intrahepatic biliary radical dilatation. Endoscopic ultrasound-guided fine-needle aspiration done from the pancreatic head lesion was diagnostic of tuberculosis. The patient was started on antitubercular medications

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2

Karki, Shovana, Sonafi Shrestha, Sansar B. Tiwari, and Paleswan Joshi Lakhey. "Histopathological Findings of Pancreaticoduodenectomy Specimens in a Tertiary Care Hospital in Nepal." Journal of Institute of Medicine Nepal 43, no. 3 (2021): 15–20. http://dx.doi.org/10.59779/jiomnepal.1180.

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Introduction: Among the gastrointestinal malignancies, 5% of the tumors comprise peri-ampullary carcinomas. Adenocarcinoma is the commonest malignancy in the peri-ampullary region. The important histopathological prognostic factors are tumor size, location, extension, resected marginal status, lymphovascular (LVI) and perineural invasion (PNI) and lymph nodal status. This study was conducted to analyze the lesions and to describe the associated histopathological parameters. Methods: This study was carried out in the Department of Pathology, TUTH, Kathmandu, includes pancreatico-duodenectomy sp

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3

Gunay, Yusuf, Ebru Demiralay, and Alp Demirag. "Pancreatic Metastasis of High-Grade Papillary Serous Ovarian Carcinoma Mimicking Primary Pancreas Cancer: A Case Report." Case Reports in Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/943280.

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Introduction. Reports of epithelial ovarian carcinomas metastatic to the pancreas are very rare. We herein present a metastasis of high grade papillary serous ovarian cancer to mid portion of pancreas.Case. A 42-year-old patient was admitted with a non-specified malignant cystic lesion in midportion of pancreas. She had a history of surgical treatment for papillary serous ovarian adenocarcinoma. A cystic lesion was revealed by an abdominal computerized tomography (CT) performed in her follow up . It was considered as primary mid portion of pancreatic cancer and a distal pancreatectomy was perf

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4

Nishith, Nilay, Ram Nawal Rao, and Praveer Rai. "Cytologic Categorization with Risk Stratification of Endoscopic Ultrasound-Guided Fine Needle Aspiration from Pancreatic Lesions Based on Guidelines of the Papanicolaou Society of Cytopathology: 12-Year Tertiary Care Experience." Discoveries 9, no. 3 (2021): e134. http://dx.doi.org/10.15190/d.2021.13.

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Background and Aims: Pancreatic malignancy is an important cause of cancer mortality worldwide. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) plays a crucial role in the pre-operative diagnosis of pancreatic lesions. In this study, we have analyzed the cytological spectrum of pancreatic lesions in the Indian population over 12 years, categorized them according to the Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology (PSCPC), and assessed the risk of malignancy (ROM) for each of the categories. Methods: A computerized data search from January

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5

Smith, LR, W. Coomer, S. Gupta, and T. Boyce. "Jaundice and a testicular lump: a rare cause of malignant biliary obstruction." Annals of The Royal College of Surgeons of England 104, no. 1 (2022): e4-e5. http://dx.doi.org/10.1308/rcsann.2020.7109.

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Biliary obstruction from metastatic deposits in the pancreas is rare. We present a case of primary testicular lymphoma (PTL) with pancreatic metastasis. A 56-year-old man presented to the general surgical department with signs and symptoms of obstructive jaundice. A computed tomography scan revealed multiple pancreatic metastases and a right primary testicular malignancy. Histology and positron emission tomography scanning subsequently confirmed PTL with pancreatic metastases. Metastasis to the pancreas from primary testicular malignancy is extremely rare. There is variation in prognosis betwe

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6

Sarwar, Maryem, Yumnah Babar, and Sundas Saba. "Pancreatic tuberculosis presenting as gastric outlet obstruction: a case report." Journal of Rehman Medical Institute 11, no. 1 (2025): 35–37. https://doi.org/10.52442/jrmi.v11i1.864.

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Pancreatic tuberculosis is an uncommon yet significant condition that can mimic malignant diseases, leading to challenges in diagnosis and management. It can present as gastric outlet obstruction due to swelling and inflammation, extrinsic compression, fibrosis and stricture formation. In such scenarios diagnosis of pancreatic tuberculosis should be considered especially in areas with high prevalence of tuberculosis. This case report presents a 68-year-old male exhibiting atypical symptoms of gastric outlet obstruction. Initial assessment suggested a potential malignancy, as imaging revealed

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7

Khalil, Beemen, Ayotunde Adeyeri, and Alexius Ramcharan. "Pancreatic Tuberculosis Mimicking Malignancy." Journal of the American College of Surgeons 208, no. 3 (2009): 476–77. http://dx.doi.org/10.1016/j.jamcollsurg.2008.06.328.

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8

Parihar, Ashwin Singh, Harmandeep Singh, Rajender Kumar, Vikas Gupta, Harpreet Singh, and Bhagwant Rai Mittal. "Pancreatic Malignancy or Not?" Clinical Nuclear Medicine 43, no. 4 (2018): e115-e117. http://dx.doi.org/10.1097/rlu.0000000000001989.

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9

Solomon, A., A. Green, and S. Russell. "Pancreatic malignancy and diabetes." Practical Diabetes International 25, no. 3 (2008): 95. http://dx.doi.org/10.1002/pdi.1216.

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10

Ratra, Atul, Busara Songtanin, Dauod Arif, and Kanak Das. "Rare solid pseudopapillary neoplasm in a Caucasian man." Southwest Respiratory and Critical Care Chronicles 12, no. 50 (2024): 52–55. http://dx.doi.org/10.12746/swrccc.v12i50.1283.

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Pancreatic pseudopapillary neoplasms are rare pancreatic tumors and have a female predominance. Clinical manifestations include abdominal pain and/or an abdominal mass. Some patients are asymptomatic, and the tumors are found incidentally on imaging. Endoscopic ultrasound with fine needle biopsy with pathological tissue remains the gold standard for diagnosis. The malignant potential is low, and surgery remains the standard treatment. Keywords: Solid pseudopapillary neoplasm, pancreatic tumor, pancreatic malignancy, endoscopic ultrasound

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11

Manohar, Murli, Alok K. Verma, Sathisha Upparahalli Venkateshaiah, and Anil Mishra. "Mechanistic role of eosinophils in the initiation and progression of pancreatitis pathogenesis." Journal of Immunology 198, no. 1_Supplement (2017): 66.2. http://dx.doi.org/10.4049/jimmunol.198.supp.66.2.

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Abstract Several clinical reports indicated that IL-18 and eosinophils are induced in patient with chronic pancreatitis and pancreatic malignancy. However, the etiology and pathogenesis of eosinophilic pancreatitis (EP) is poorly understood and termed as rare disease. Accordingly, we tested the hypothesis that IL-18 and IL-5 synergy may be critical in promoting EP pathogenesis. We performed qPCR, ELISA, western blot, immunofluorescence and immunohistochemical analyses to detect eosinophils, mast cells, collagen, associated cytokines and chemokines in experimental and human pancreatitis. Herein

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12

Syal, Arshi, Yajur Arya, Bruce Adrian Casipit, and Claudia Dourado. "Outcomes among patients with pancreatic malignancy on long-term anticoagulation hospitalized for acute pulmonary embolism: A nationwide analysis." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16266-e16266. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16266.

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e16266 Background: Pancreatic cancer is known to have an increased risk of thromboembolic events. Acute pulmonary embolism further complicates the clinical picture and confers a poor prognosis in this population. Data regarding prophylactic anticoagulation in patients with pancreatic malignancy is lacking, although there is evidence that prophylaxis does reduce incidence of venous thromboembolism in pancreatic malignancy. Whether this benefit equates to improved clinical outcomes needs further clarification. Methods: We utilized the 2018-2020 National Inpatient Sample (NIS) Database in conduct

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13

Spier, Bret J., Eric A. Johnson, Deepak V. Gopal, et al. "Predictors of Malignancy and Recommended Follow-Up for Patients with Negative Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Suspected Pancreatic Lesions." Canadian Journal of Gastroenterology 23, no. 4 (2009): 279–86. http://dx.doi.org/10.1155/2009/870323.

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BACKGROUND: Endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) can characterize and diagnose pancreatic lesions as malignant, but cannot definitively rule out the presence of malignancy. Outcome data regarding the length of follow-up in patients with negative or nondiagnostic EUS-FNA of pancreatic lesions are not well-established.OBJECTIVE: To determine the long-term outcome and provide follow-up guidance for patients with negative EUS-FNA diagnosis of suspected pancreatic lesions based on imaging predictors.METHODS: A retrospective review of patients undergoing EUS-FNA for suspecte

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14

Salahuddin, Ayesha, and Muhammad Wasif Saif. "Pancreatic Tuberculosis or Autoimmune Pancreatitis." Case Reports in Medicine 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/410142.

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Introduction. Isolated pancreatic and peripancreatic tuberculosis is a challenging diagnosis due to its rarity and variable presentation. Pancreatic tuberculosis can mimic pancreatic carcinoma. Similarly, autoimmune pancreatitis can appear as a focal lesion resembling pancreatic malignancy. Endoscopic ultrasound-guided fine needle aspiration provides an effective tool for differentiating between benign and malignant pancreatic lesions. The immune processes involved in immunoglobulin G4 related systemic diseases and tuberculosis appear to have some similarities.Case Report. We report a case of

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15

Ekberg, O., M. Bergenfeldt, P. Aspelin, et al. "Reliability of Ultrasound-Guided Fine-Needle Biopsy of Pancreatic Masses." Acta Radiologica 29, no. 5 (1988): 535–39. http://dx.doi.org/10.1177/028418518802900509.

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Fine-needle aspiration biopsy (FNB) was performed with ultrasound guidance in 79 patients in whom sonography had revealed a mass suggesting pancreatic malignancy. The final diagnosis (surgery, autopsy and clinical course) in 69 of these 79 patients was a malignancy closely related to the pancreas while in the remaining 10 patients benign disease was confirmed. A correct diagnosis of malignancy was attained by FNB in 59 of the 69 patients with a malignant tumour while in 10 it failed to confirm the diagnosis. FNB yielded a true negative result in 10 patients with benign disease. The accuracy of

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16

Newman, Naeem A., John T. Lucas, Diandra A. Peacock, et al. "Predictors for readmission after pancreatic resection for malignancy." Journal of Clinical Oncology 31, no. 4_suppl (2013): 301. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.301.

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301 Background: Readmission after pancreatic resection has been reported as high as 50%. This study was undertaken to determine factors predicting readmission after pancreatic resection for malignancy. Methods: We reviewed the medical records of 202 patients to identify patients that had a pancreatic resection for malignancy between 2003 and 2010. Outcome measures included patient characteristics, medical comorbidities, and perioperative factors. Results: A total of 202 patients underwent pancreatic resection for malignancy. AJCC T stage was T1, T2, T3, and T4 in 10.9%, 26.3%, 52% and 9.2% res

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17

Zhao, Jin, Sharon X. Liang, Lou Savas, and Barbara F. Banner. "An Immunostaining Panel for Diagnosis of Malignancy in Mucinous Tumors of the Pancreas." Archives of Pathology & Laboratory Medicine 125, no. 6 (2001): 765–69. http://dx.doi.org/10.5858/2001-125-0765-aipfdo.

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Abstract Background.—The diagnosis of malignancy in pancreatic mucinous cystic tumors depends on demonstrating invasion that may be focal and require extensive sectioning. Objective.—To explore markers that may indicate malignant potential in mucinous cystic tumors. Design.—Routinely processed sections from resected specimens of 12 normal pancreata, 14 pancreata with chronic pancreatitis, 9 mucinous cystic tumors, and 30 invasive adenocarcinomas were immunostained with antibodies to p53, HER-2/neu, epithelial growth factor receptor (EGFR), transforming growth factor α (TGF-α), and Ki-67. Resul

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18

Weinstein, David, Sarah Burroughs, Robert Toelke, Raza Muhammad, and Farhan Quader. "S2686 Pancreatic Tail Plasmacytoma Mimicking Primary Pancreatic Malignancy." American Journal of Gastroenterology 119, no. 10S (2024): S1875—S1876. http://dx.doi.org/10.14309/01.ajg.0001040112.19000.43.

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19

Ullah, A. K. M. Ahsan, S. M. Ferdous Ahmed, A. S. M. Lokman Hossain Chowdhury, Saad Mohammed, M. Mozammel Haque, and Abunur M. Masud Rana. "Evaluation of serum carbohydrate antigen 19-9 as a diagnostic marker for pancreatic malignancy." International Surgery Journal 7, no. 9 (2020): 2824. http://dx.doi.org/10.18203/2349-2902.isj20203762.

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Background: Carbohydrate antigen (CA) 19-9 is considered as a tumor marker in biliary-pancreatic malignancy. Though a high level may indicate the presence of a malignant disorder, it may rise even in benign condition. Similarly, the value may be normal even in malignant condition.Methods: An observational comparative study was conducted in the Department of Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from 01 June 2016 to 31 May 2017 to find out the sensitivity and specificity of CA 19-9 as a tumor marker in pancreatic malignancy in our perspective and to find out a cu

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20

Lai, Jian-Han, Keng-Han Lee, Chen-Wang Chang, Ming-Jen Chen, and Ching-Chung Lin. "Predicting Factors for Pancreatic Malignancy with Computed Tomography and Endoscopic Ultrasonography in Chronic Pancreatitis." Diagnostics 12, no. 4 (2022): 1004. http://dx.doi.org/10.3390/diagnostics12041004.

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Diagnosing pancreatic malignancy is challenging, especially in patients with chronic pancreatitis (CP). Endoscopic ultrasonography (EUS) is a promising diagnostic procedure for discriminating between malignancy and CP. We aimed to investigate the predictive factors and reliability of computed tomography (CT) and EUS for differentiating pancreatic mass lesions and the diagnostic accuracy of EUS-FNA or FNB in patients with CP. Forty patients with CP, receiving CT and EUS-FNA or FNB for pancreatic mass lesion evaluation, were enrolled in the study. Patients’ data, CT and EUS characteristics, imag

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21

Henkes, David N., Sandeep N. Patel, Laura A. Rosenkranz, and Jose L. Escobedo. "The Utility of UroVysion Fluorescence In Situ Hybridization in Pancreatic Fine-Needle Aspiration Samples Directed and Obtained by Endoscopic Ultrasonography." Archives of Pathology & Laboratory Medicine 137, no. 1 (2013): 64–71. http://dx.doi.org/10.5858/arpa.2011-0241-oa.

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Context.—The diagnosis of pancreatic adenocarcinoma can be challenging for the pathologist. Endoscopic ultrasound-guided, fine-needle aspiration (EUS-FNA) can be used to obtain samples of pancreatic masses. UroVysion fluorescence in situ hybridization (UFISH) has been reported to increase the sensitivity and to be very specific for the diagnosis of adenocarcinoma when combined with cytology in the diagnosis of biliary brushings and washings. Objectives.—To determine the sensitivity and specificity of UFISH on tissues obtained from pancreatic lesions suggestive of adenocarcinoma obtained by EUS

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22

Nadir, Adnan Hacım. "A Rare Benign Pancreatic Lesion Mimicking Malignancy- Eosinophilic Pancreatitis." Archives of Clinical Gastroenterology 4, no. 2 (2017): 020–22. https://doi.org/10.17352/2455-2283.000052.

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Background: Eosinophilic infiltration of the pancreas is usually associated with generalized diseases like “sclerosing pancreatitis”, “eosinophylic gastroenteritis” and “systemic mastocytosis”. Most patients have systemic findings such as eosinophilia, elevated IgE levels and gastrointestinal tract infiltration Isolated eosinophilic infiltration of the pancreas is much less common and is usually found in the histological evaluation of pancreatic specimens resected with the misdiagnosis of pancreatic cancer. 

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23

Diaz-Rubio, Jose Luis, Andres Duarte-Rojo, Milena Saqui-Salces, Armando Gamboa-Dominguez та Guillermo Robles-Diaz. "Cellular Proliferative Fraction Measured With Topoisomerase IIα Predicts Malignancy in Endocrine Pancreatic Tumors". Archives of Pathology & Laboratory Medicine 128, № 4 (2004): 426–29. http://dx.doi.org/10.5858/2004-128-426-cpfmwt.

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Abstract Context.—Endocrine pancreatic tumors (EPTs) are rare lesions with varying biological behavior. Establishing malignancy is a challenge for clinicians and pathologists. Objective.—To establish the role of proliferative, apoptotic, angiogenic, and hormonal markers as predictors of malignancy in EPTs. Design.—Paraffin-embedded EPT samples were studied for prognostic markers. Patients.—Twenty-one consecutive patients with a diagnosis of EPT. Main Outcome Measures.—The proliferative fraction (topoisomerase IIα), microvascular density (CD34), vascular endothelial growth factor expression, an

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24

Lad, D. L., L. K. V. Lad, N. C. Jhala, and A. Toha. "EUS-Guided FNA Biopsy of Solid Pancreatic Lesions: A Review of 111 Cases and Comparative Study of Diff-Quik/PAP/Thin Prep Staining Techniques." Journal of Global Oncology 4, Supplement 2 (2018): 216s. http://dx.doi.org/10.1200/jgo.18.87400.

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Background: Pancreatic cancer is the fourth leading cause of cancer associated deaths in the United States and ranks ninth in its incidence. EUS-guided FNA cytology has emerged as an important diagnostic tool since Vilman and Grimm (1992) made the first reports of endoscopic guided fine needle aspiration. Currently, EUS-guided FNA biopsy of the pancreas is a standard practice for the diagnosis and staging of pancreatic malignancy. Aim: The current study was carried out with the following objectives. 1. To find out the diagnostic accuracy, sensitivity, and specificity of EUS-guided FNA of the p

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25

Benny, PB, TA Vasu, VK Muhsin, and Ilakkia Selvan. "Distal pancreatic tumour - Masquerading malignancy." Kerala Surgical Journal 27, no. 1 (2021): 91. http://dx.doi.org/10.4103/ksj.ksj_12_21.

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26

Shulik, Oleg, Yana Cavanagh, and Matthew Grossman. "Pancreatic Lesion: Malignancy or Abscess?" American Journal of Case Reports 17 (May 18, 2016): 337–39. http://dx.doi.org/10.12659/ajcr.895621.

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27

Ussui, Vivian, Lavinia Goldstein, Enrico O. Souto, and Cynthia Levy. "Portal Cavernoma Mimicking Pancreatic Malignancy." American Journal of Gastroenterology 112 (October 2017): S693—S694. http://dx.doi.org/10.14309/00000434-201710001-01276.

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28

Ussui, Vivian M., Lavinia Goldstein, Enrico Souto, and Cynthia Levy. "Portal Cavernoma Mimicking Pancreatic Malignancy." ACG Case Reports Journal 5, no. 1 (2018): e15. http://dx.doi.org/10.14309/crj.2018.15.

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29

Jha, Priyanka, Bijan Bijan, Giselle Melendres, and David K. Shelton. "Hybrid Imaging for Pancreatic Malignancy." Clinical Nuclear Medicine 40, no. 3 (2015): 206–13. http://dx.doi.org/10.1097/rlu.0000000000000677.

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30

Raghavan, Pooja, and Dhyan Rajan. "Isolated Pancreatic Tuberculosis Mimicking Malignancy in an Immunocompetent Host." Case Reports in Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/501246.

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Despite the high prevalence of tuberculosis (TB) worldwide, pancreatic TB is rare. When present, pancreatic TB is frequently associated with miliary TB, often in immunocompromised hosts. Pancreatic TB may present as a pancreatic abscess, acute or chronic pancreatitis, and cystic or solid pancreatic masses. We present a case of an immunocompetent patient who presented with two discrete pancreatic masses and was subsequently diagnosed with isolated pancreatic TB. This case suggests that clinicians should have a heightened suspicion of pancreatic TB when faced with discrete pancreatic lesions, es

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31

Kanamori, Akane, Daisuke Matsubara, Yurika Saitoh, et al. "Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1." Oncogene 39, no. 39 (2020): 6218–30. http://dx.doi.org/10.1038/s41388-020-01423-8.

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Abstract Pancreatic cancer is one of the most fatal cancers without druggable molecular targets. Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcriptional factor that promotes malignancy in various cancers including pancreatic cancer. Herein, we found that HIF-1 is accumulated in normoxic or moderate hypoxic areas of pancreatic cancer xenografts in vivo and is active even during normoxia in pancreatic cancer cells in vitro. This prompted us to analyze whether the HIF-1 activator Mint3 contributes to malignant features of pancreatic cancer. Mint3 depletion by shRNAs attenuated HIF-1

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Nwafor, Divine C., Ashley B. Petrone, Joseph M. Collins, and Amelia K. Adcock. "Paraneoplastic Opsoclonus Myoclonus in a Patient with Pancreatic Adenocarcinoma." Case Reports in Neurological Medicine 2019 (April 16, 2019): 1–3. http://dx.doi.org/10.1155/2019/3601026.

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Opsoclonus myoclonus syndrome (OMS) is an extremely rare neurological syndrome typically affecting as few as 1 in 10,000,000 people annually. OMS is characterized by the presence of involuntary, saccadic eye movements, as well as ataxia, including gait incoordination, rigidity, and tremor. The origin of OMS is unclear, but a significant percentage of OMS cases are indicative of an underlying malignancy, most commonly neuroblastoma and small cell lung cancer. Here we describe an adult patient with OMS, who was ultimately diagnosed with a small ductal adenocarcinoma of the pancreas. To our knowl

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Zhang, Yajun, and Yuhong Tao. "Pediatric Pancreatic Tuberculosis: A Case Report and Review of the Literature." Case Reports in Pediatrics 2018 (August 30, 2018): 1–3. http://dx.doi.org/10.1155/2018/5215128.

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Pancreatic tuberculosis (TB) is an uncommon form of extrapulmonary TB and represents a diagnostic challenge for physicians. Pancreatic TB presents with nonspecific signs and symptoms and may mimic malignancy. However, pancreatic TB rarely occurs in children. Here, we present a case of a 5-year-old girl with pancreatic TB and markedly elevated serum cancer antigen- (CA-) 125 levels, thus raising the suspicion of malignancy, but positivity forMycobacterium tuberculosisDNA was noted. The patient recovered after being administered standard antitubercular therapy for one year. This case suggests th

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34

Timmaraju, Venkata Arun, Sydney David Finkelstein, and Jonathan Adam Levine. "Analytical Validation of Loss of Heterozygosity and Mutation Detection in Pancreatic Fine-Needle Aspirates by Capillary Electrophoresis and Sanger Sequencing." Diagnostics 14, no. 5 (2024): 514. http://dx.doi.org/10.3390/diagnostics14050514.

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Pancreatic cystic disease, including duct dilation, represents precursor states towards the development of pancreatic cancer, a form of malignancy with relatively low incidence but high mortality. While most of these cysts (>85%) are benign, the remainder can progress over time, leading to malignant transformation, invasion, and metastasis. Cytologic diagnosis is challenging, limited by the paucity or complete absence of cells representative of cystic lesions and fibrosis. Molecular analysis of fluids collected from endoscopic-guided fine-needle aspiration of pancreatic cysts and dilated du

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35

Matsushita, Mitsunobu, Tsukasa Ikeura, Masaaki Shimatani, et al. "Pancreatic Cystic Neoplasms: Imaging Surveillance for Pancreatic and Extra-Pancreatic Malignancy." American Journal of Gastroenterology 104, no. 4 (2009): 1055. http://dx.doi.org/10.1038/ajg.2009.17.

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36

Lokanatha, Orauganti PhD. "Eosinophils have a critical role in promoting pancreatic malignancy in experimental chronic pancreatitis." Internation J. Cell Biology and Physiology 5, no. 1&2 (2022): 1–4. https://doi.org/10.2364326/IJCBP.ISP.

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37

Moiseenko, V. E., A. V. Pavlovsky, D. A. Granov, I. G. Kardanova, L. V. Kochorova, and I. V. Dodonova. "Incidence of pancreatic malignancies in the Russian Federation: a retrospective cohort trial." Kuban Scientific Medical Bulletin 28, no. 3 (2021): 97–111. http://dx.doi.org/10.25207/1608-6228-2021-28-3-97-111.

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Background. Pancreatic malignancies pose a challenging medical and social problem. The assessment of oncology care requires an in-depth analysis of morbidity and lethality. At a relatively improved prevalence and lethality in other-locale malignancies, pancreatic cancer remains a disappointing situation. Medical statistics in pancreatic malignancy can be used for the specialty care prediction and implementation of measures to advance diagnostic algorithms and population screening.Objectives. An assessment of the pancreatic malignancy incidence and mortality in the adult population of Russian F

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38

Lee, S., and J. Y. Cho. "Use of endoscopic ultrasound scoring to estimate the malignant potential of branch duct type intraductal papillary-mucinous neoplasms of the pancreas." Journal of Clinical Oncology 29, no. 4_suppl (2011): 182. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.182.

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182 Background: Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas are characterized by intraductal papillary epithelial growth, mucin hypersecretion, and cystic dilation of main or branch pancreatic ducts. However, it is still difficult to differentiate between benign and malignant, when it only involves the branch duct. The purpose of this study was to evaluate the role of endoscopic ultrasound (EUS) scoring in predicting malignancy in branch-duct type IPMNs, thus providing a convenient guideline to a clinician before considering surgical resection. Methods: We retrospectively

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Al Najdi, NouraAbdulaziz, BasimAbdulrazzak Felemban, and AhmedHaroun Abou Issa. "Pancreatic tuberculosis causing biliary obstruction and mimicking pancreatic malignancy." Journal of Health Specialties 6, no. 1 (2018): 39. http://dx.doi.org/10.4103/jhs.jhs_106_17.

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40

Kothadia, Jiten P., Vyshnavi Kone, and Abbas Raza. "Primary Pancreatic Lymphoma: A Rare Cause of Pancreatic Malignancy." American Journal of Gastroenterology 112 (October 2017): S690—S691. http://dx.doi.org/10.14309/00000434-201710001-01269.

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Harindranath, Sidharth, and Sridhar Sundaram. "Approach to Pancreatic Head Mass in the Background of Chronic Pancreatitis." Diagnostics 13, no. 10 (2023): 1797. http://dx.doi.org/10.3390/diagnostics13101797.

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Chronic pancreatitis (CP) is a known risk factor for pancreatic cancer. CP may present with an inflammatory mass, and differentiation from pancreatic cancer is often difficult. Clinical suspicion of malignancy dictates a need for further evaluation for underlying pancreatic cancer. Imaging modalities remain the mainstay of evaluation for a mass in background CP; however, they have their shortcomings. Endoscopic ultrasound (EUS) has become the go-to investigation. Adjunct modalities such as contrast-harmonic EUS and EUS elastography, as well as EUS-guided sampling using newer-generation needles

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Lochan, R., A. K. Daly, H. L. Reeves, and R. M. Charnley. "Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma." Journal of Oncology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/215985.

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Aim. To examine interaction between history of cancer in first-degree relatives and tobacco smoking in index patients of pancreatic adenocarcinoma.Methods. We carried out a case-control involving 113 patients with pancreatic adenocarcinoma and 110 controls over a 12-month period at the Freeman Hospital, Newcastle upon Tyne, UK. They were all administered a detailed tobacco exposure questionnaire and a family history questionnaire. We calculated cumulative tobacco exposure and risk for pancreas cancer.Results. Both smokers (OR 3.01 (95% CI: 1.73 to 5.24)) and those with a family history of mali

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David, Charles, Melian Zhuo, Yong Li, et al. "Abstract C069: A conserved reepithelialization program driven by FOSL1 underlies malignancy in pancreatic ductal adenocarcinoma." Cancer Research 84, no. 17_Supplement_2 (2024): C069. http://dx.doi.org/10.1158/1538-7445.pancreatic24-c069.

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Abstract Benign lesions named pancreatic intraepithelial neoplasia (PanIN) are frequent in the healthy population but are precursors to deadly pancreatic ductal adenocarcinoma (PDAC). Conversion of PanINs to PDAC is poorly understood. Here we harness high resolution spatial transcriptomics to identify a core transcriptional program associated with invasive growth across human PDAC and required for PanIN-to-PDAC progression in mice. The malignancy program is lineage restricted, and predominantly comprised of transcripts activated to drive reepithelialization during skin wound healing. This woun

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Iskandar, Mazen E., Michael G. Wayne, Justin G. Steele, and Avram M. Cooperman. "Familial Pancreatic Cancer: The Case for Prophylactic Pancreatectomy in Lieu of Serial Screening and Shared Decision Making." Case Reports in Oncological Medicine 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/737183.

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At-risk family members with familial pancreatic cancer (FCaP) face uncertainty regarding the individual risk of developing pancreatic cancer (CaP) and whether to choose serial screening or prophylactic pancreatectomy to avoid CaP. We treated 2 at-risk siblings with a history of FCaP, congenital hepatic fibrosis (CHF), and jaundice secondary to a bile duct stricture. In one, a pancreaticoduodenal resection was done and in the second a total pancreatectomy. Malignancy was not present, but extensive pancreatic intraepithelial neoplasia (PanIn) 2 was present throughout both pancreata. The clinical

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Anil, Mishra. "Possible novel non-invasive biomarker for chronic inflammation induced chronic pancreatitis associated malignancy." Int. J. Basic Clin. Immonol 3, no. 1-4 (2020): 1–8. https://doi.org/10.1076/iJbCI.ISP.

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<strong>Objectives: </strong>Pancreatic malignancy is a major public health problem worldwide and recent reports indicated that pancreatic cancer will be second most common cause of cancer-related deaths by the end of 2021. The cause of increasing death rate is due to the nonexistence of detection tools to early diagnose, poor prognosis, resistance to chemotherapy and also lack in understanding the mechanism of PDAC pathogenesis. Circulating tumor cells (CTCs) play a major role in metastatic step of intravasation and presence of these cells are strong prognostic marker for the progression of p

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Sathisha, Upparahalli Venkateshaiah, Kumar Kandikattu Hemanth, Kumar Sandeep, and Mishra Anil. "Possible novel non-invasive biomarker for inflammation mediated pancreatic malignancy." International Journal of Basic and Clinical Immunology (Int. J. Basic. Clin. Immunol. 3, no. 1-4 (2020): 1–8. https://doi.org/10.1077/IJBCI.ISP.

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<strong>Objectives: </strong>Pancreatic malignancy is a major public health problem worldwide and recent reports indicated that pancreatic cancer will be second most common cause of cancer-related deaths by the end of 2021. The cause of increasing death rate is due to the nonexistence of detection tools to early diagnose, poor prognosis, resistance to chemotherapy and also lack in understanding the mechanism of PDAC pathogenesis. Circulating tumor cells (CTCs) play a major role in metastatic step of intravasation and presence of these cells are strong prognostic marker for the progression of p

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Abdellah, Tarek, Sayed Shalaby, Amira Salem та ін. "Pancreatic cyst fluid interleukin-1 beta (IL-1β) level in predicting the risk of malignancy in pancreatic cysts". Egyptian journal of Immunology 29, № 4 (2022): 75–83. http://dx.doi.org/10.55133/eji.290407.

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Pancreatic cystic lesions (PCLs) may be accidentally discovered in up to 13.5% of cases. These PCLs are of multiple types, including mucinous cysts (intra-ductal papillary mucinous neoplasms [IPMN] and mucinous cystic neoplasms [MCN]) that have a risk of malignant transformation. The difficulty in differentiation between the various PCLs and their unpredictable risk of malignant transformation makes their management difficult. The new diagnostic tools of PCLs often include endoscopic ultrasound guided fine needle aspiration (EUS-FNA) for pancreatic cyst fluid analysis. This study aimed to dete

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Ali, Md Akmat, and Richmond Ronald Gomes. "ERCP in Bilio-pancreatic malignancy: Demographic profile among Bangladeshi patients." Gazette of Medical Sciences 2, no. 2 (2021): 4–9. http://dx.doi.org/10.46766/thegms.oncol.21030603.

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Outcome of most of the biliary and pancreatic malignancy is not good. Demography and involvement of different sites of these malignancies by endoscopic retrograde cholagiopancreatography (ERCP) are not widely studied in Bangladesh. We have studied ERCP based different biliary and pancreatic malignancy and their demographic characteristics.

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Jang, Sung Ill, See Young Lee, Ji Hae Nahm, et al. "A New Staining Method Using Methionyl-tRNA Synthetase 1 Antibody for Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology of Pancreatic Cancer." Diagnostics 15, no. 14 (2025): 1783. https://doi.org/10.3390/diagnostics15141783.

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Background/Objectives: Accurate determination of malignancy in pancreatic masses through endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is crucial for appropriate clinical management and prognostic assessment. However, the diagnostic sensitivity of conventional cytology using Papanicolaou (Pap) staining remains limited, often leading to inconclusive results. In this study, we investigated the diagnostic utility of methionyl-tRNA synthetase 1 (MARS1) through immunohistochemical (IHC) and immunofluorescence (IF) staining as a potential biomarker for pancreatic cancer. IHC analysis

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Keane, Margaret G., Hannah R. Dadds, Ghassan El Sayed, et al. "Clinical and radiological features that predict malignant transformation in cystic lesions of the pancreas: a retrospective case note review." AMRC Open Research 1 (February 19, 2019): 4. http://dx.doi.org/10.12688/amrcopenres.12860.1.

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Background: Pancreatic cystic lesions (PCL) are being detected with increasing frequency. Current methods of stratifying risk of malignant transformation are imperfect. This study aimed to determine the frequency of pancreatic malignancy in patients with PCL and define clinical and radiological features that predict malignant transformation in patients managed by surgery and/or surveillance. Methods: A retrospective cohort of adults who were evaluated in a tertiary hepatopancreaticobiliary centre between January 2000 - December 2013 with a confirmed PCL and followed up for at least 5 years. Al

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