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Dissertations / Theses on the topic 'Pancreatic necrosis'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Molloy, Sally Dixon. "A DNA Vaccine Against Infectious Pancreatic Necrosis Virus." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/MolloySD2007.pdf.

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2

Bain, Nicola. "Understanding host-pathogen interactions of infectious pancreatic necrosis virus (IPNV)." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158418.

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Sequencing and phylogenetic analysis was used to characterise a number of Scottish IPNV isolates. The majority of isolates from Scotland were genetically closely related to the Sp strain of IPNV. There appears to be a link between the IPN status of a farm and the presence of IPNV in the environment but this is short lived as IPNV does not typically persist in natural reservoirs at sufficiently high levels to allow re-infection to occur. Real-time PCR was used to study the expression of a subset of immune relevant genes following IPNV challenges by a natural (co-habitation) and unnatural (i.p.)

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Knott, Rachel M. "The persistence of infectious pancreatic necrosis virus in Atlantic salmon." Thesis, University of Aberdeen, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330104.

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The persistence of infectious pancreatic necrosis virus (IPNV) in Atlantic salmon was examined with particular emphasis on the association of IPNV with leucocytes. Atlantic salmon were infected with IPNV via the water and via the feed. Despite relatively low mortalities, a high prevalence of IPNV was demonstrated particularly when the virus was introduced via the water. No virus-specific pathology or reduction in the growth performance of infected populations was evident. The conditions for the stimulation of Atlantic salmon leucocytes with the mitogen, phytohemagglutinin (PHA) were optimised

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Мадяр, Володимир Васильович, Владимир Васильевич Мадяр, Volodymyr Vasylovych Madiar та І. Г. Каплун. "Комплексне лікування панкреонекрозу". Thesis, Вид-во СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/7553.

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5

Mangunwiryo, Hariyadi. "Aspects of infectious pancreatic necrosis (IPN) virus infections in farmed fish." Thesis, Kingston University, 1988. http://eprints.kingston.ac.uk/20347/.

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A rainbow trout (Slamo gairdneri Richardson) population of IPN virus carriers was studied over a one-year period using both homogenisatian and co-cultivation for virus isolation. The percentage of virus-yielding fish was high between March and June but then declined. This was diametrically opposite to the trend in the serum antibody levels indicating that the marked humoral immune response resulted in a very significant reduction in the virus titres. The highest isolation rate was obtained from the kidneys after co-cultivation (from seventeen of the twenty-three virus-positive fish) underlinin

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6

Plant, Karen Patricia. "Studies on resistance to infectious pancreatic necrosis virus in Atlantic salmon (Salmo salar)." Thesis, University of Stirling, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365033.

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7

Bossard, Maud. "The role of epithelial cell-derived tumour necrosis Factor Alpha in pancreatic carcinogenesis." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8563.

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Activating mutations of the kras proto-oncogene are found in more than 90% of human pancreatic ductal adenocarcinoma (PDAC) and can result in increased activity of the NF-κB pathway, leading to constitutive production of proinflammatory cytokines such as TNF-α. Pancreatic cancer progression occurs through a series of pre-invasive lesions, pancreatic intraepithelial neoplasias (PanIN lesions), which progress into invasive carcinoma. The aim of this thesis is to understand the autocrine role of TNF-α produced by premalignant epithelial cells in pancreatic tumour progression. This cytokine has al

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8

Guy, Derrick Richard. "Genetic resistance to infectious pancreatic necrosis virus in pedigreed atlantic salmon (Salmo salar)." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5293.

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Infectious Pancreatic Necrosis (IPN), due to infection with the IPN virus (IPNv), continues to cause heavy mortalities and is endemic across the major Atlantic salmon farming regions of the world. Prevalances of 0.3-0.8 or more at the freshwater stage and 0.05 to 0.3 in the seawater phase of production are typical. Partially effective injectable vaccines are available against seawater IPN but biosecurity measures remain the main methods of control. To explore the feasibility of selecting salmon for resistance to IPN, a selective breeding program was initiated in 1996, including a series of fie

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9

Song, Haichen. "Functional studies of infectious pancreatic necrosis virus proteins and mechanism of virus-induced apoptosis." College Park, Md. : University of Maryland, 2003. http://hdl.handle.net/1903/144.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2003.<br>Thesis research directed by: Animal Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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10

Daud, Hassan Bin Hj Mohd. "Experimentally induced infectious pancreatic necrosis (IPN) virus infection in common carp ('Cyprinus carpio', Linnaeus)." Thesis, Kingston University, 1989. http://eprints.kingston.ac.uk/20349/.

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11

Tsuji, Yoshihisa. "Perfusion computerized tomography can predict pancreatic necrosis in early stages of severe acute pancreatitis." Kyoto University, 2010. http://hdl.handle.net/2433/120574.

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12

Stead, Aileen. "The application of recombinant DNA technology to the study of the infectious pancreatic necrosis virus." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068186.

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Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an economically important pathogen in the fish farming industry. The aim of this project was to apply the techniques of recombinant DNA technology to develop methods for the detection of IPNV nucleic acid and the classification of IPNV strains, and to the production of a recombinant vaccine. A polymerase chain reaction (PCR) protocol was developed to amplify cDNA encoding three regions of the IPNV/Sp strain genome: the VP2 and the VP3 genes, encoding the major and minor structural proteins respectively, and the hypervariable region

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13

McKinley, Gavin. "The innate immune response of Atlantic salmon head kidney macrophages to Infectious Pancreatic Necrosis Virus (IPNV)." Thesis, University of Stirling, 2007. http://hdl.handle.net/1893/243.

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Infectious pancreatic necrosis virus (IPNV) is the aetiological agent of infectious pancreatic necrosis (IPN), a disease associated with serious economic loss in Atlantic salmon (Salmo salar). The interaction between IPNV and the host is poorly characterised. IPNV has been detected within macrophages in natural and experimental infections. The macrophage is an important component of the host immune system, participating in innate and adaptive immune responses. The overarching objective of this project was to study aspects of the interaction between IPNV and innate immune responses in the Atlan

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14

Henderson, Rachael A. "Investigation of proteins from infectious pancreatic necrosis virus important for protection in Atlantic salmon (Salmo salar)." Thesis, University of Aberdeen, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421329.

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Infectious Pancreatic Necrosis Virus (IPNV) belongs to the birnavirus genes, family <i>Birnaviridae, </i>and has classically been shown to be virulent to salmonid fish, including Atlantic salmon (<i>Salmo salar).</i> This study was oriented around this pathogen; it’s structural proteins in particular, namely viral proteins 2 and 3 (VP2 and VP3). Two VP2 fragments were expressed in <i>E. coli</i> and full length VP3 was expressed in <i>Pichia</i>. These proteins were tested for their abilities to confer protection against IPNV in an Atlantic salmon trial. The serum was analysed by ELISA against

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Ulrich, Kristina. "Molecular epidemiological study on Infectious Pancreatic Necrosis Virus isolates from aquafarms in Scotland over three decades." Thesis, University of Stirling, 2018. http://hdl.handle.net/1893/28340.

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Introduction: RNA viruses are economically important pathogens of fish, and among these viruses, infectious pancreatic necrosis virus (IPNV) is of particular concern for the aquaculture industry, especially for farmed rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar). This non-enveloped aquatic virus, which was first isolated in the UK in 1971, belongs to the family of Birnaviridae and has a bi-segmented dsRNA genome of about 6kb. IPNV is classified in 6 genogroups with correspondence to 10 known serotypes and an additional proposed genogroup of marine aquabirnaviruses (MAB

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Almeida, Daria Raquel Queiroz de. "Terapia fotodinâmica em células de tumores pancreáticos humanos: eficiência e análise das vias mediadoras de citotoxicidade." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24082018-090240/.

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O adenocarcinoma de ducto pancreático (PDAC) é a quarta causa de morte em decorrência de neoplasias nos países ocidentais. Atualmente, a cirurgia ressectiva é a única possibilidade de cura para a doença, porém, a recidiva tumoral acontece em menos de um ano após a intervenção cirúrgica, mesmo com a quimioterapia adjuvante. A terapia fotodinâmica (PDT) é uma alternativa promissora no tratamento do câncer. No entanto, pouco se sabe sobre o uso da PDT em tumores pancreáticos. Portanto, o objetivo deste trabalho foi avaliar a eficiência da PDT com o azul de metileno (MB) como fotossensibilizador (

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17

Thorvaldson, Lina. "Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8228.

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18

Holstad, Maria. "Prevention of type 1 diabetes mellitus in experimental studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4972-7/.

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19

LAVIGNE, LAURENCE. "Pancreatite aigue : evaluation de nouveaux marqueurs de gravite." Toulouse 3, 1993. http://www.theses.fr/1993TOU31521.

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Malaquias, Ana Rita Santos Patrício. "Complicações da pancreatite aguda." Master's thesis, Universidade da Beira Interior, 2008. http://hdl.handle.net/10400.6/818.

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A pancreatite aguda define-se como um processo inflamatório do pâncreas e a sua incidência tem aumentado mas últimas décadas, em vários países. Apesar do processo patológico poder ser limitado ao pâncreas, a chamada pancreatite aguda ligeira, também pode condicionar envolvimento local e sistémico. Um episódio de pancreatite aguda grave tem uma taxa de mortalidade elevada e a sua abordagem correcta é ainda alvo de controvérsia. O conhecimento limitado da fisiopatologia e a multi-causalidade da doença dificultam o seguimento e a terapêutica. A estratificação do risco, com identificação p

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Leyton, Rossi Rodrigo Alonso. "Expresión heteróloga de la proteína IFN-I del sistema inmune de Salmo salar en Bacillus megaterium." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/170084.

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Memoria para optar al título de Bioquímico<br>La industria acuícola de salmónidos, como la del salmón del Atlántico o de la trucha arcoíris, constituye una de las principales actividades económicas de Chile. Sin embargo, en su puesta en marcha enfrenta desafíos técnicos y ambientales, incluyendo la aparición de enfermedades que se transmiten rápidamente dentro de las poblaciones de cultivo. La segunda causa de pérdidas por patología infecciosa es la Necrosis Pancreática Infecciosa, causada por el virus IPNv. Se ha descrito que la citoquina IFN-I induce una potente actividad antiviral contra IP

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22

Matheus, André Siqueira. "Efeito da inibição da produção de TNF-alfa por meio da administração de pentoxifilina na pancreatite aguda experimental." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-16102014-095603/.

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Pancreatite aguda é uma das principais causas de síndrome da resposta inflamatória sistêmica (SRIS). Complicações sistêmicas são os principais fatores responsáveis pela ocorrência de falência de múltiplos órgãos e sistemas e morte durante a primeira etapa da doença. Os níveis de mediadores inflamatórios possuem uma relação com a gravidade da pancreatite. O TNF-alfa tem sido descrito como o agente iniciador da resposta inflamatória da pancreatite aguda. Estudos prévios usando a pentoxifilina para bloquear a produção de TNF-alfa têm demonstrado efeitos benéficos quando usada em modelos experimen

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23

Damasceno, Samara Rodrigues Bonfim. "Effect anti-necrotic of ConA and ConBr lectins in pancreatic acinar cell injury induced by bile salt, alcohol, and palmitoleic acid: involvement of the lectin domain." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13880.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Acute pancreatitis is an inflammatory disease of the pancreas which involves a complex sequence of pathophysiological events, many of which are still unknown. Recent data give more importance to the events that happen within the pancreatic cell. The severity and duration of the stimulus applied to pancreatic acinar cells may lead to apoptosis or necrosis. A large number of studies have demonstrated that the lectin of Canavalia ensiformis (ConA) and Canavalia brasiliensis (ConBr) induce cell death by apoptosis in various cell type

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Chou, Yi-Li, and 周宜黎. "Molecular apoptotic mechanism of infectious pancreatic necrosis virus vp3." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/ea97z2.

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碩士<br>國立成功大學<br>生物科技研究所碩博士班<br>92<br>From the previous study, the Infectious Pancreatic Necrosis Virus (IPNV) could induces Chinook salmon embryo cell (CHSE-214) death through apoptosis, but whether viral gene could involved in host cell death still don’t known. On the other hand, from our preliminary data shown that we found overexpression the vp3 could rapidly induce 3T3 cell death after 24hr incubation. So in this study,we want to examine vp3 how to induce apoptotic death and its molecular-death mechanism in 3T3 cells. 　　Interestingly,we found that the bad gene could be induced at 24hr post

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Chuang, Shu-Chin, and 莊舒菁. "Establishment of Rapid Diagnosis Methods of Infectious Pancreatic Necrosis Virus." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/15576223721267300536.

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碩士<br>國立臺灣大學<br>獸醫學系<br>86<br>Since isolated from rainbow trout in 1983 in Taiwan, the IPNV (Infectious Pancreatic Necrosis Virus) was identified in many kind of marine and fresh water fish continuously. In addition to horizontal transmission between fish, the vertical transmission via carrier and eggs causes a large number of deaths of fingerlings. Because the source of rainbow trout eggs completely depends on importation, this experiment is designed to build a rapid diagnos

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Ju, Wan-Geng, and 朱萬庚. "Studies on the Genmoic Sequence of Aquatic Infectious Pancreatic Necrosis Virus." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/92435947722352141486.

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碩士<br>國立海洋大學<br>生物技術研究所<br>84<br>IPNV-E1S,the Ab type of aquatic birnavirus, has a bisegmented dsRNA genome which consists of 3.2 Kb A segment and 2.9 Kb B segment. The large ORF of A segment mainly encodes three viral proteins including VP2 (capsidprotein),VP4 (protease) and VP3 (internal structure protein). B segment encodes RNA-dependent RNA polymerase. The serotype-specific epitope contained in VP2 is critical to the detection and vaccine production of IPNV. For determining the functi

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HUNG, TSANG-YU, and 洪滄佑. "The Relationship between Infectious Pancreatic Necrosis Virus ( IPNV ) and Cellular Siganl Transduction." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/62461097272439037206.

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碩士<br>東吳大學<br>微生物學系<br>85<br>Infectious pancreatic necrosis virus (IPNV) is classified into the familyof Birnaviridae. In IPN viruses, there are both virulent and avirulent strains.The infection of virulent strains sometimes causes 90% to 100% of mortality in fish aquaculture. Under environmental stress, even the avirulent strain cancause 60% to 90% of mortality. The pathogenic mechanisms of IPNV virulence are still obscure. In the present study, the original Buhl strain (VR-299 serotype)of

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LIU, ZHEN, and 劉貞. "Molecular characterization of infectious pancreatic necrosis virus persistent infection in TO-2 cells." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/03292267282938217454.

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HE, GUO-MOU, and 何國牟. "Molecular cloning and structure study of infectious pancreatic necrosis virus (IPNV) RNA genome." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/72161707526265899358.

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LIN, RONG-HUANG, and 林榮煌. "Biochemical characteristics of infectious pancreatic necrosis virus (IPNV)-E1-S isolated from eel." Thesis, 1985. http://ndltd.ncl.edu.tw/handle/54287344513382844285.

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Lin, Chih-Hsin, and 林志信. "The Preliminary Study of Infectious Pancreatic Necrosis Virus VP3 Gene Function and DNA Vaccine." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/45455236972550483778.

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碩士<br>國立海洋大學<br>水產養殖學系<br>87<br>Infectious pancreatic necrosis virus(IPNV), a birnavirus, is an important pathogen in fish farms. In Taiwan, IPNV has caused great damages and loss in the aquacultures of tilapia, eel, milk fish and clam. Therefore, how to effectively control the IPNV infection is an important issue to the aquacultures.To order to study the gene function and develop of DNA vaccine. So construction of the expression vector is the first, the VP2 and VP3 cDNA clones of IPNV were cloned into the pCDNA3 expression vector for mammalian cell. It contains cytomegalovirus (CMV) immediate

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Hong, Jiann-Ruey, and 洪健睿. "Induction and molecular regulation of host cell apoptosis by infectious pancreatic necrosis virus infection." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/52401582092286857870.

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博士<br>國防醫學院<br>生命科學研究所<br>87<br>English abstract Apoptosis is an active process of cell death that serves diverse functions in multicellular organisms, and under physiological conditions, it is tightly controlled. Apoptosis is often implicated in the elimination of cells whose survival might be harmful to organism as a whole; for example, the mechanisms have evolved to target virus-infected cells for apoptotic cell death. Infectious pancreatic necrosis virus (IPNV) is an economically important fish pathogen and belongs to Birnaviridae virus family. E1-S of IPNV Ab strain was isol

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LIU, MING-CAN, and 劉銘燦. "Characterization of guanylyltransferase and genome-linked viral proteins in infectious pancreatic necrosis virus(IPNV)." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/99252866365564274869.

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Bruslind, Linda D. "Pathogenic and molecular characterization of three closely related isolates of infectious pancreatic necrosis virus (IPNV)." Thesis, 1997. http://hdl.handle.net/1957/34139.

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Three closely related isolates belonging to the A�� serotype of infectious pancreatic necrosis virus (IPNV) were selected for comparison, to provide insight into the nature of variation in the virulence of IPN viruses. Brook trout fry (Salvelinus fontinalis) were experimentally infected with the three isolates by immersion. Cumulative mortalities over a 62 day period for the three isolates were 67%, 78%, and 93%. The negative control was 3%. Virus titers from whole fish homogenates sampled at peak mortality for each isolate were statistically similar, indicating that quantity of virus does no

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Kao, Yi-Feng, and 高翊峰. "Effect of Infectious pancreatic necrosis virus (IPNV) on the tolerance of grouper to Znic and Cadium." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/29161438142057484990.

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Hsiao, Yieh-Her, and 蕭亦何. "Inhibition of infectious pancreatic necrosis virus infection by hammerhead ribozyme expression in TO-2 cell line." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/35581115536878182347.

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碩士<br>國立海洋大學<br>水產生物技術研究所<br>87<br>Infectious pancreatic necrosis virus (IPNV) is one kind of the contagious and widespread fish diseases. IPNV belongs to the Birnaviridae family of virus, which has bisegmented ds-RNA genomes and often causes sever damage to the aquaculture industry in Taiwan. The purpose of this study was to investigate whether the expression of hammerhead ribozyme in persistent Tilapia ovary-2 (TO-2) cells can protect the cells from viral replication. Seven target sites of hammerhead ribozyme were selected according to secondary structure of VP2 cDNA sequence pred

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LI, QING-CHUN, and 李慶春. "In vitro studies of selected antiviral agents against fish birnavirus, infectious pancreatic necrosis virus (IPNV)-T42G." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/55532335076135594602.

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Wang, Wei-Lun, and 汪惟倫. "Hammerhead ribozymes on the cleavage of VP5 RNA in infectious pancreatic necrosis virus (IPNV) at low temperature." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/65367701652998611726.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>88<br>Infectious pancreatic necrosis virus (IPNV) is one of the contagious and widespread fish diseases. IPNV belongs to the Birnaviridae family of virus, which has bisegmented ds-RNA genomes and often causes seriously damages to the aquaculture in Taiwan. VP5 is encoded from the small ORF located at 5' end of A segment. VP5 protein had been demonstrated to play a dual role on the regulation of virus replication and up-regulation of the survival factor Mcl-1 during IPNV infection. In this study, we designed highly specific hammerhead ribozymes to test the cleavages o

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Mason, Carla L. "Molecular characterization of the proteinase and RNA-dependent RNA polymerase of Infectious Pancreatic Necrosis Virus, a fish birnavirus." Thesis, 1992. http://hdl.handle.net/1957/36739.

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The A segment of infectious pancreatic necrosis virus (IPNV) is expressed as a polyprotein encoding three primary gene products, VP2, NS and VP3, from a large open reading frame. The nucleotide sequence for the A segment of the Sp isolate of IPNV was determined. The NS protein is the putative autocatalytic proteinase responsible for the cleavage of the polyprotein. The functional boundaries of the NS proteinase were mapped by plasmid deletion analysis and examined in an La vitro, translation system. The NS proteolytic activity was determined to lie within the EcoRI and Nsil restriction sites.

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LIN, MAO-XIANG, and 林茂香. "Viral interference and defective interfering particles of infections pancreatic necrosis virus HB-1 isolate from clam meretrix iusoria." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/13692382735402652981.

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碩士<br>輔仁大學<br>生物學研究所<br>75<br>IPN 病毒類，HB-1文蛤病毒分離株在高濃度下經4 個月繼代培養，發現病毒效價有波動情形，其波動度高於以低濃度感染之病毒，因其教價會降低，且皆低於以低濃度接種之繼代病毒，顯示有病毒干擾現象。取經40代高濃度繼代之高毒與正常低濃度感染之病毒，於同時間內分別純化，取得多DI病毒及多正常病毒之收集管。將兩者之收隻管加以分析，多DI管感染效價最高在第7 收集管，干擾效價最高在第9 收集管，正常病毒之感染效價最高在第7 收集管，且其所有收集管均測不到干擾現象，觀測其蛋白質電泳分析圖譜，發現兩者之α、β蛋白質群有差異，γ蛋白質群則其相同分子量之蛋白質，多成熟DI管之α蛋白質分子量分別為94Kd ，105Kd，成熟正常病毒為94Kd，多成熟DI管之β蛋白質分子量分別為50Kd ，51Kd，成熟正常病毒為52.3Kd ，推測分子量50Kd及105Kd 者為成熟DI特有之蛋白質，應和干擾現象有關。至於以10％聚烯醯胺分析基因

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QI, XIAO-QI, and 齊肖琪. "The studies of aquatic birnaviruses serotyping and defective interfering particles by monoclonal antibodies against infectious pancreatic necrosis virus." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/23353535233520235723.

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Park, Kyoung Chul. "Characterization of an inhibitor ("6S") of infectious pancreatic necrosis virus (IPNV) in normal rainbow trout serum (RTS) and its effects on the virus." Thesis, 2000. http://hdl.handle.net/1957/32673.

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The characteristics of an inhibitor of infectious pancreatic necrosis virus (IPNV) found in normal rainbow trout serum (RTS) were studied. The serum inhibitor had a molecular weight of approximately 150 kDa and was dependent on divalent cations, either Ca�� or Mg��. It was stable at temperatures up to 50��C and at a pH range between 4-10. The inhibitor directly inactivated the virus and the inhibition level was dependent on cell densities and on the time at which virus was exposed to RTS. The level of virus inhibition by RTS was altered by the cell line in which virus was produced. IPNV

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彭翠儀. "Effect of Heavy Metal Stressors and Salinity Shock on the SUsceptibity of Grouper (Epinephelus sp.) to Infectious Pancreatic Necrosis Virus (IPNV)." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/29710907019237768850.

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李盈撰. "The changes of cell cycle progression and cellular signal transduction in Chinook salmon embryonic cells-214 after infectious pancreatic necrosis virus (IPNV-T42G) infection." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/86420717104336373660.

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碩士<br>國立海洋大學<br>水產養殖學系<br>90<br>Abstract Infectious pancreatic necrosis virus (IPNV) belongs to the Birnaviridae family. It is currently one of the most serious infectious diseases in fish farming. Though IPNV was originally isolated as long as early 1960s, little is known about the mechanism related to the viral induced intracellular molecular changes that support viral replication. In this thesis we try to assess the cell cycle progression of the infected cells and to assess the potential role of cellular signal transduction in IPNV replication. In

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Chen, Meei Mei, and 陳媺玫. "Characterization of a virally persistently infected cell line derived from swimming bladder of black carp and the infectious pancreatic necrosis virus isolated from this cell line." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/68509626368651220127.

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博士<br>國立臺灣大學<br>動物學系<br>81<br>SB細胞株源自青魚鰾組織，在初級細胞培養時，即表現出喪失停泊依賴性，喪失接觸抑制性，血清依賴性降低及高群落形成率等腫瘤細胞特性，以倒立顯微鏡觀察，SB細胞以纖維母細胞為主，其間夾雜許多巨大細胞。以 Acridine orange 染色，並以螢光顯微鏡觀察，可觀察到在這些巨大細胞細胞質的位置有黃綠色包涵體，應為雙股核酸病毒的包涵體。在掃描式電子顯微鏡下，SB細胞表現鋪展不良，富於長微絨毛等強轉型細胞特性。SB 細胞的培養液接種於CCT及TO-2細胞，導致嚴重細胞病變。這些結果顯示，SB細胞源自腫瘤組織，並有雙股核醣核酸病毒的持續性感染。以穿透式電子顯微鏡觀察此尾青魚之組織，在前腎可觀察到細胞質空泡化，細胞核膜增生等病變，並可觀察到二十面體病毒的存在。 SB細胞亦有類似細胞病變，但病變的程度嚴重並且在細胞質可觀察到大量病毒及病毒質的戌b ，病毒顆粒之直徑約 55-70nm。分析病毒來源

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HONG, WEN-LING, and 洪紋玲. "Gene cloming of the capsid protein of infectious pancreation necrosis virus (IPNV)." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/53503771843342273784.

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碩士<br>東吳大學<br>生物學研究所<br>80<br>T42G病毒為本實驗室在1987年鹿谷養鱒場發生大量鱒魚死亡時，由其病魚體所分離到的一種具兩段雙股核醣核酸病毒，在分類上屬於Birnaviridae，為感染性胰臟壞 ▔▔▔▔▔▔ 死病毒（infectious pancreatic necrosis virus, 簡稱IPNV）之VR-299電泳型。其基因體大小為Ａ段3.8kb 及Ｂ段3.2kb ，分別轉譯四個病毒蛋白（Ａ段）及核醣核酸轉錄酵素(RNA transcriptase) （Ｂ段）。本實驗 T42G 病毒的 cDNA 是利用 hexanucleotide當作random primer 或用專一性引導子(specific primers)及反轉錄酵素(reverse transcriptase) 來合成的，雙股核醣核酸的第一階段變性條件，以處理一次所合成之cDNA的產率優於處理兩次者，且當引導子與核醣核酸模板之用

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Miranda, Joana Santos. "Proteína C-reativa como fator preditivo de necrose na pancreatite aguda." Master's thesis, 2020. http://hdl.handle.net/10451/48011.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020<br>A pancreatite aguda é uma das patologias mais comuns do trato gastrointestinal, com morbi-mortalidade consideráveis, em particular se associada a necrose pancreática. Pretendemos avaliar a associação entre os valores de marcadores inflamatórios e a necrose pancreática e, no caso particular da proteína C reativa (PCR), determinar os timings e valores de cut-off consistentes. Estudo de coorte retrospetivo, com recolha de dados de indivíduos adultos, que recorreram ao Serviço de Urg

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Fael, Mariana Ferreira. "Pancreatite aguda necrotizante em idade pediátrica : a propósito de um caso clínico." Master's thesis, 2020. http://hdl.handle.net/10451/48240.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020<br>A pancreatite aguda (PA) é uma doença transversal a todas as faixas etárias. A sua incidência em crianças e jovens tem vindo a aumentar, exigindo a atenção dos profissionais de saúde da área pediátrica médica e cirúrgica. A morbilidade e mortalidade da doença nesta população não são desprezíveis, variando consoante diversos fatores. Neste trabalho é descrito o caso de um adolescente que apresentou pancreatite aguda grave com necrose pancreática extensa, em conjunto com cetoacidose

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