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Dissertations / Theses on the topic 'Pancreatic neuroendocrine tumour'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Gill, Preetjote. "Studies In Patients With Surgically Resected Pancreatic Neuroendocrine Tumours - MicroRNA Expression And Clinical Correlation." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18181.

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INTRODUCTION Pancreatic Neuroendocrine Tumours (PNETS) have increased in incidence over the past three decades. Treatment options currently include surgery, locoregional and systemic therapies, however the prognosis remains poor and biomarkers that accurately predict the clinical behavior of these tumours are lacking. Dysregulation of microRNAs (miRNAs) has recently been shown to play a role in the development of many cancers through post-transcriptional gene regulation, however, few studies have investigated the role of miRNAs as diagnostic or prognostic markers in PNETs. METHODS Patients un

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2

De, Cassan Chiara. "Elastography mean strain histogram value for the differential diagnosis of malignant pancreatic masses: a monocentric study." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424524.

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Introduction Endoscopic ultrasound (EUS) elastography is a recent ultrasound method used for the real-time visualization and evaluation of tissue elasticity. Qualitative and quantitative methods have been used, in particular in evaluation of pancreatic diseases and malignant lymph nodes, with interesting results regarding the accuracy and the differential diagnosis between malignant and benign masses. No consensus has been reached with regard to the superiority of different quantitative methods, but strain ratio and strain histogram (SH) remain the most used. SH corresponds to a graphical re

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3

Hanson, Matthew Richard. "Expression studies on PPARγ in pancreatic neuroendocrine tumours". Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/710.

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Pancreatic NETs occur with an annual incidence of around 5 per 1,000,000 population per year, with survival rates of between 30 – 97% at 5 years depending on the tumour subtype. The PPARs (peroxisomal proliferator-activated receptors) are members of the nuclear receptor superfamily that includes receptors for thyroid, steroid and retinoid hormones. PPARγ protein is also thought to be expressed in human pancreatic islet cells and has been shown to be a negative regulator of islet β cell mass both in vivo and in vitro. Its emerging function in controlling cell proliferation, differentiation and

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4

Bösch, Florian [Verfasser], and Markus [Akademischer Betreuer] Guba. "Single center experience in pancreatic neuroendocrine tumors / Florian Bösch. Betreuer: Markus Guba." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1081899859/34.

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5

Yamauchi, Yuki. "Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264634.

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京都大学<br>新制・論文博士<br>博士(医学)<br>乙第13418号<br>論医博第2226号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授羽賀博典, 教授長船健二, 教授伊藤貴浩<br>学位規則第4条第2項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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6

Körner, Jan Lennart [Verfasser], and Roland [Akademischer Betreuer] Kontermann. "Target identification and probe development for pancreatic neuroendocrine tumors / Jan Lennart Körner. Betreuer: Roland Kontermann." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2015. http://d-nb.info/1069290211/34.

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7

ANDREASI, VALENTINA. "ROLE OF CHROMOGRANIN A-DERIVED FRAGMENTS AND OTHER BIOMARKERS IN PANCREATIC NEOPLASMS: FOCUS ON NEUROENDOCRINE TUMORS." Doctoral thesis, Università Vita-Salute San Raffaele, 2021. http://hdl.handle.net/20.500.11768/121777.

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Introduction: The lack of valid biomarkers represents a major unmet clinical need in pancreatic neuroendocrine neoplasms (PanNENs). Chromogranin A (CgA) is the most commonly measured PanNEN biomarker, despite relevant limitations related to variable sensitivity, poor specificity and lack of assay standardization. Therefore, novel biomarkers are needed to improve diagnosis, detect disease recurrence and assess treatment response. In this project, the role of CgA-derived fragments as PanNEN biomarkers was investigated, focusing on the N-terminal peptide vasostatin-1 (VS-1). A multianalyte biomar

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8

Örlefors, Håkan. "Positron Emission Tomography in the Management of Neuroendocrine Tumors." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3356.

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<p>Neuroendocrine tumors (NET´s) are often characterized by overproduction of peptide hormones. In spite of pronounced clinical symptoms, the tumor lesions can be small and difficult to detect. The general aim of this thesis was to investigate, in vitro and in vivo, some of the potential monoamine pathways present in NET´s, using radiolabeled tracers for positron emission tomography (PET), with the intention to explore the value of PET-imaging in the management of NET´s.</p><p>We used the 11C-labeled serotonin precursor 5-hydroxy tryptophan (HTP) as the tracer for imaging of NET´s. More than 9

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9

Capodanno, Ylenia. "Identifying therapeutic implications of cancer stem cells in human and canine insulinoma." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31175.

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Pancreatic neuroendocrine tumours (PNETs) are the most common neuroendocrine tumours diagnosed in humans and dogs. Due to the highly heterogeneous nature of these tumours, definitive data are still lacking over the molecular mechanisms involved in their cancerous behaviour. This study focused on insulinoma (INS), as it is the most commonly diagnosed PNET in human and veterinary oncology. INS is an insulin-producing tumour that causes a hypoglycaemic syndrome related to the excessive insulin production. In humans, it is often a small benign neoplasm readily curable by surgical resection whereas

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10

Ekeblad, Sara. "Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7937.

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11

Behrang, Yasmin [Verfasser]. "Etablierung und Charakterisierung eines neuen humanen, hochdifferenzierten und funktionell-aktiven Tumormodells eines pankreatischen neuroendokrinen Tumors : Establishment and Characterization of a Novel Well-differentiated and Functionally Active Human Pancreatic Neuroendocrine Tumor Model / Yasmin Behrang." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1221084143/34.

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12

CATALDO, Ivana. "Landscape of genomic alteration of Pancreatic Neuroendocrine Tumours." Doctoral thesis, 2017. http://hdl.handle.net/11562/961508.

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Pancreatic Neuroendocrine Tumors (PanNETs) are rare malignancies with a wide range of clinical-pathological characteristics and different prognosis with a challenging clinical management. They typically carry out modifications of tumour suppressor pathways and no oncogenic alterations have been found yet. The recent acquisitions on the biological behavior of these rare tumors, due to the analysis of large cohorts of patients with consistent follow up data, lead to a change in classification of PanNETs in recent years. Our group recently identified novel pathways (mTOR, chromatin-remodeling an

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13

AMATO, Eliana. "Aberrant methylation and chromosomal alterations involving RASSF1 locus in pancreatic neoplasms." Doctoral thesis, 2010. http://hdl.handle.net/11562/343714.

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RASSF1 è un gene soppressore tumorale, la cui ipermetilazione del promotore è stata associata alla patogenesi di diversi tipi di tumore, tra cui i tumori endocrini del pancreas (PET) e il più aggressivo adenocarcinoma pancreatico (PDAC). La perdita allelica della regione 3p21.3, in cui è compreso il locus di RASSF1, è inoltre un evento che è stato recentemente associato all’insorgenza dei PET. Tuttavia, studi precedenti non hanno fornito un prova sperimentale diretta dell’effettiva riduzione dell’espressione di RASSF1A, in relazione alla metilazione. In questo studio è stata condotta un’analis

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14

Correia, Bárbara Costa. "Pancreatic Neuroendocrine Tumors: from diagnosis to therapeutics." Master's thesis, 2020. https://hdl.handle.net/10216/128086.

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15

Correia, Bárbara Costa. "Pancreatic Neuroendocrine Tumors: from diagnosis to therapeutics." Dissertação, 2020. https://hdl.handle.net/10216/128086.

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16

BERSANI, Samantha. "Molecular characterization of Pancreatic NeuroEndocrine Tumors (PanNETs)." Doctoral thesis, 2014. http://hdl.handle.net/11562/706564.

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Scopo: identificare le alterazioni molecolari clinicamente rilevanti associate ai tumori neuroendocrini del pancreas (PanNETs). Materiali e Metodi: 204 pazienti sono stati studiati per la ricerca mutazionale in 8 geni frequentemente alterati in PanNETs utilizzando Tecnologia Ion Torrent. Tali geni si dividono tra MEN1, ATRX e DAXX coinvolti nel rimodellamento della cromatina, PIK3CA,TSC2,PTEN,MTOR implicati nel mTOR pathway e infine ATM presente come ruolo centrale nel mantenimento della stabilità e riparazione del DNA. Inoltre sono stati valutati: i) le variazioni del numero di copie (C

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17

Roy, Rakhi Chanda. "Cysteine metabolism and pancreatic neuroendocrine tumors (PNETs) chemoresistance." Master's thesis, 2019. http://hdl.handle.net/10362/87825.

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Cancer is characterised as a set of diseases that is involved in uncontrolled cell growth with the ability to invade or spread to the other part of the body. Carcinogenesis is recognized as a process through aggregation of genetic and epigenetic changes in normal cell that ultimately leading to unlimited growth proliferation and invasion. Pancreatic neuroendocrine tumour (PNET) is a rare tumour that arise from neuroendocrine gland, occurs in various part of the body. The prevalence rate of PNETs is near about 25–30 per 100,000 population in the United States and according to Surveillance Epide

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18

Sá, Ana Isabel da Rocha. "Evaluation of a novel mouse model of pancreatic neuroendocrine tumors." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/109412.

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19

Sá, Ana Isabel da Rocha. "Evaluation of a novel mouse model of pancreatic neuroendocrine tumors." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/109412.

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20

BONINSEGNA, Letizia. "Incidental nonfunctioning pancreatic endocrine tumors: clinical and surgical implications." Doctoral thesis, 2012. http://hdl.handle.net/11562/394335.

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Introduzione: l’attuale diffusione e maggior accessibilità delle tecniche imaging negli ultimi anni hanno aumentato l’incidenza di riscontro di neoplasie endocrine non-funzionanti del pancreas (NF-PNETs) asintomatiche. I NF-PNETs incidentali (I-NF-PNETs) solitamente presentano diametro e stadio minori rispetto ai NF-PNETs sintomatici (S-NF-PNETs) ed il riscontro occasionale sembra rappresentare un fattore prognostico favorevole sia per lo stadio di malattia sia per il grading istologico. Vi è comunque una assenza di dati circa la gestione dei I-NF-PETs potenzialmente non aggressivi. Obiettivi:

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21

PARTELLI, Stefano. "OBSERVATIONAL STUDY OF NATURAL HISTORY OF SMALL SPORADIC NONFUNCTIONING PANCREATIC NEUROENDOCRINE TUMORS." Doctoral thesis, 2014. http://hdl.handle.net/11562/716561.

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Introduzione: I tumori pancreatici neuroendocrini non funzionanti (NF-PNET) asintomatici ben differenziati sono un’entità sempre più spesso diagnosticata e la loro gestione è controversa vista la loro buona prognosi seppur eterogenea. Scopo: Scopo dello studio è stato quello di valutare la storia naturale dei NF-PNET sporadici asintomatici con diametro < 2 cm valutando il rapporto rischio-beneficio di una gestione conservativa. Metodi: Tra Gennaio 2000 e Giugno 2011, 46 pazienti con una diagnosi di NF-PNET < 2 cm sono stati inseriti in un programma di follow-up di almeno 18 mesi con imagin

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22

Paiella, Salvatore. "Preoperative fine-needle aspiration of pancreatic neuroendocrine tumors: a reliable tool to assess diagnosis and grading - A prospective single-center analysis of 100 cases." Doctoral thesis, 2019. http://hdl.handle.net/11562/994779.

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Background & Aims:Fine-needle aspiration (FNA) of pancreatic neuroendocrine tumors (Pan-NENs) has been proposed to obtain the grading, using Ki-67 proliferation index calculation. Data on reliability of grading (G) and Ki-67 index calculations from FNA cell blocks are controversial as there are potential limitations. Methods:One hundred patients subjected to FNA for a presumed PanNEN and subsequent resection material were evaluated at a single institution. FNA was obtained with endoultrasonography or with a percutaneous approach. Ki-67 calculation was performed using WHO guidelines. A com

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23

Gupta, Aparna. "Neuroendocrine prostate tumors mimic endocrine differentiation of pancreatic beta cells in 12T-10 mice foxa2 and mash-1 the key players /." Diss., 2007. http://etd.library.vanderbilt.edu/ETD-db/available/etd-07302007-134815/.

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24

Chou, Wen Chi, and 周文其. "The significance of plasma chromogranin A levels and gene mutation profiles of patients with pancreatic neuroendocrine tumors in Taiwan." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/v9juf9.

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博士<br>長庚大學<br>臨床醫學研究所<br>106<br>Gastroenteropancreatic neuroendocrine tumors (GEP NET) is the second most prevalent malignancy in the gastrointestinal tract. The differences in epidemiological distribution of and genetic alterations in pancreatic NETs in Western and Eastern populations imply different pancreatic NET pathogenesis between patients of different ethnicities. Chromogranin A (CgA) expression generally correlates with activity of neuroendocrine cells. The immunohistochemical staining of CgA in tumor cells is the gold standard for diagnosis of NETs, however, circulatory CgA levels hav

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