Academic literature on the topic 'Pang huang (Lu, Xun)'

Abstract Antibody-drug conjugates (ADCs) such as HER2 ADC Enhertu and TROP2 ADC Trodelvy have been proved to be the promising therapeutic agents in portion of cancer diseases. However, there are still numerous patients refractory to the therapy, indicating that the efficacy of ADCs may need to be further optimized. Here, we report that the excessive cancer-associated fibroblasts (CAFs) can serve as a fibrotic barrier, to the detriment of anti-tumor effects from ADCs by alleviating their tissue penetration. Mechanistically, the cancer cells can transform the normal fibrotic cells into CAFs which are featured by the hyperactivated focal adhesion kinase (FAK) signaling. The fast-growing CAFs would decrease the tumor uptake of the big molecules, conferring drug resistance of ADCs to the cancer cells. Targeting FAK with a small molecule inhibitor IN10018 is capable to reduce CAFs associated tumor barrier, elevating the tissue penetration of different types of ADCs regardless their respective targets. The combination regimen comprising IN10018 and the ADCs targeting either HER2 or TROP2 outperformed each monotherapy with respect to antitumor outcomes in different animal experiments. The preclinical evidence for the dual regimen of IN10018 and ADCs warrants a further validation in clinical settings. Citation Format: Baoyuan Zhang, Zhixiang Zhang, Jiaming Gao, Shiqiang Lu, Ran Pang, Dongfang Li, Xun Huang, Natasha Qin, Leo Liu, Zaiqi Wang. Targeting FAK improves the tumor penetration of antibody-drug conjugates to strengthen the anti-cancer responses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4655.

Abstract. City is a symbol of modernity. The revival of the Urban Fiction genre in contemporary Chinese literature is driven by writers of the 1970s. It portrays not only urban landscapes with the beauty in their works, but also exposes the souls that suffer in urban spaces. As a symbol of a modern, advanced and civilized life portrayed in Huang Yongmei's short story "Rearview Mirror", it has a dark side. Various changes that move to bring progress do not necessarily change the fate and fortune of urban people who live in it. Instead of being able to enjoy a comfortable and orderly urban space, an elderly former truck driver in the text seems to be moving back in time. Huang Yongmei, literary winner of the 7th Lu Xun literary award (2018), builds allegories about denial of the progress or modernity of today's China. The Rearview Mirror property serves as a kind of reminder of how many parts of past lives have been left behind as we go fast in the flow of change. The magnitude of the progress and the change can only be measured by constantly looking back to its rickety and worn-out past. The suffer of the city people in old age is symbolized with the scene of going backwards, as a healing therapy for the abnormal spine due to sitting behind the wheel for too long. When the city people rush over each day, this old man goes backwards. The complexity of big city problems make the elderly desperate. Widower in old age, deceived by false loyalty, habit of going back to the past have turned into a swimming backstroke. Huang Yongmei has arrived to the point of firmness by keeping the urban’s subject away from the sparkling city life that just makes the little people suffer. The Father's Rearview Mirror text asserts that the urban subject who suffers in his last days leave his hometown, for good.

Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in hematologic malignancies but limited success in solid tumors. GCC19CART, the first clinical candidate from the CoupledCAR solid tumor platform, is designed to overcome the limitations of conventional CAR T-cells in solid tumor malignancies by pairing solid tumor CAR T-cells with CD19 targeting CAR T-cells to amplify proliferation and activation of the solid tumor CAR T component. GCC19CART targets guanylate cyclase-C (GCC) which is expressed in the metastatic lesions of 70%-80% of subjects with colorectal cancers. A Phase 1 investigator-initiated clinical trial is underway in China for patients with relapsed or refractory metastatic colorectal cancer who have received at least 2 prior lines of therapy. Based on a data cutoff on October 20, 2022 21 subjects have been enrolled in 2 dose escalation groups at 5 hospitals in China. Methods: Subjects are screened for GCC expression by immunohistochemistry. Eligible subjects undergo leukapheresis, a single dose of lymphodepleting chemotherapy (fludarabine 30mg/m2 and cyclophosphamide 300mg/m2) 3 days prior to infusion, and then administration of a single infusion of GCC19CART at one of two preassigned doses: 1 × 106 or 2 × 106 CAR T-cells/kg. Endpoints are safety and preliminary evidence of efficacy as determined by CT or PET/CT per RECIST 1.1 or PERCIST 1.0. All responses were confirmed by an independent third-party imaging contract research organization (CRO). Results: 13 subjects have been enrolled to dose level 1 (1 × 106 cells/kg) and 8 subjects have been enrolled to dose level 2 (2 × 106 cells/kg). The most common adverse events were cytokine release syndrome (CRS) in 21/21 subjects (Grade 1 19/21 (90.48%) or Grade 2 2/21 (9.52%)) and diarrhea in 21/21 subjects (Grade 1 6/21 (28.57%) Grade 2 5/21 (23.81%) Grade 3 9/21 (42.86%) or Grade 4 1/21 (4.76%)). Neurotoxicity was observed in 2/21 (9.52%) subjects at Grade 3 or 4 and resolved with corticosteroids. The combined overall response rate (ORR) for both dose levels was 28.6% (6/21). For dose level 1, the overall response rate (ORR) per RECIST 1.1 was 15.4% (2/13). Two subjects demonstrated a partial response (PR) while 3 additional subjects had partial metabolic response (PMR) on PET/CT with stable disease (SD) or progressive disease (PD) per RECIST 1.1. For dose level 2, The ORR per RECIST 1.1 was 50% (4/8). 4 subjects demonstrated a PR (3 at month 1, 1 at month 3 after being SD at month 1) and 2 additional subjects had PMR on PET/CT with SD per RECIST 1.1. Conclusions: preliminary data show that GCC19CART has meaningful dose dependent clinical activity and an acceptable safety profile in relapsed or refractory metastatic colorectal cancer. This trial is ongoing and updated data will be presented. A Phase 1 trial of GCC19CART in the US under a cleared IND is expected to enroll patients from mid-2022. Citation Format: Naifei Chen, Chengfei Pu, Lingling Zhao, Ning Li, Chang Wang, Yusheng Huang, Suxia Luo, Xun Li, Zhenzhou Yang, Jun Bie, Ruihong Zhu, Xi Huang, Haiyang Tang, Tingting Liang, Yizhuo Wang, Beibei Jia, Dongqi Chen, Zhao Wu, Yongping Song, Victor Lu, Lei Xiao, Jiuwei Cui. A phase 1 dose escalation study of GCC19CART - a novel CoupledCAR therapy for subjects with metastatic colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1130.

BackgroundRecent data suggested an association between Tofacitinib treatment and increased cardiovascular events in patients with Rheumatoid arthritis. Janus Kinase inhibitors (JAKi), specifically JAK3, have been demonstrated to be one of the regulators of platelet function. Treating platelets with thrombin induces tyrosine phosphorylation of the JAK3 target substrates STAT1 and STAT3, and JAK3 deficiency in mice reduces platelet aggregation and improves event-free survival in thromboplastin-induced thromboembolism.ObjectivesThis study aimed to study the ability of the JAK1/JAK3 inhibitor, Tofacitinib, to influence platelet activity in patients with Rheumatoid Arthritis.MethodsWe enrolled patients with a diagnosis of RA according to the ACR/EULAR 2010 ACR/EULAR criteria. Peripheral blood was obtained from RA patients at the baseline and after 1, 3 and 6 months of Tofacitinib therapy.Platelet aggregation assay was performed by optical aggregometry stimulated with the thromboxane A2receptor in RA patients and controls. The aggregation test was performed before starting the therapy with Tofacitinib and after one month, three months and six months.Results25 RA patients treated with Tofacitinib were recruited, 86% female and 14 % male, with a mean age of 56.5 years (SD 9.7 yrs.), mean disease duration of 16.3 years, mean ESR 28.2 mm, mean CRP 0.9 mg/dl, mean SDAI 18.2 and mean prednisone equivalent dose 3.75 mg/die. 78% of the patients were positive for Rheumatoid factor and 57.1% for ACPA. Looking at the classical risk factors, 35.7 had hypertension, 21.4% had hypercholesterolemia, 16.2% had diabetes, and 14.2% were smokers.; only one patient had a previous cardiovascular event.The platelet aggregation was not influenced by Tofacitinib treatment at any time points (T1, T3 and T6) at any Thromboxane dose (5uM and 20 uM), furthermore did not differ from patients and controls basally (64%, SD 15.84% vs 62%, SD 10.5%).ConclusionIn conclusion, Tofacitinib does not increase platelet aggregation in patients treated for Rheumatoid Arthritis.References[1]Lu, W.-J., Lin, K.-C., Huang, S.-Y., Thomas, P. A., Wu, Y.-H., Wu, H.-C., Lin, K.-H., & Sheu, J.-R. (2014). Role of a Janus kinase 2-dependent signaling pathway in platelet activation.Thrombosis Research,133(6), 1088–1096.[2]Parra-Izquierdo, I., Melrose, A. R., Pang, J., Lakshmanan, H. H. S., Reitsma, S. E., Vavilapalli, S. H., Larson, M. K., Shatzel, J. J., McCarty, O. J. T., & Aslan, J. E. (2022). Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function.Platelets,33(3), 404–415.AcknowledgementsResearch was supported by an unrestricted grant by Pfizer.Disclosure of InterestsDaniele Mauro Grant/research support from: Research was supported by an unrestricted grant by Pfizer, Daniela Iacono Grant/research support from: Research was supported by an unrestricted grant by Pfizer, Ilenia Pantano Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Maura Raimondi Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Maria Laura Marchesano Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Flavia Riccio Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Anna Pellegrino Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Vasiliki Liakouli Grant/research support from: Some research was supported by an unrestricted grant by Pfizer, Francesco Ciccia Grant/research support from: Some research was supported by an unrestricted grant by Pfizer.

The work describes the technology of a liquid crystal cell with a tapered optical fiber as an element providing light. The tapered optical fiber with the total optical loss of 0.22 ± 0.07 dB, the taper waist diameter of 15.5 ± 0.5 μm, and the elongation of 20.4 ± 0.3 mm has been used. The experimental results are presented for a liquid crystal cell filled with a mixture 1550* for parallel orientation of LC molecules to the cross section of the taper waist. Measurement results show the influence of the electrical field with voltage in the range of 0-200 V, without, as well as with different modulation for spectral characteristics. The sinusoidal and square signal shapes are used with a 1-10 Hz frequency range. Full Text: PDF ReferencesZ. Liu, H. Y. Tam, L. Htein, M. L.Vincent Tse, C. Lu, "Microstructured Optical Fiber Sensors", J. Lightwave Technol. 35, 16 (2017). CrossRef T. R. Wolinski, K. Szaniawska, S. Ertman1, P. Lesiak, A. W. Domański, R. Dabrowski, E. Nowinowski-Kruszelnicki, J. 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Abstract Background: Despite a high response rate to cCRT, patients with limited-stage SCLC generally experience recurrence of disease after a few months and survival remains poor. Immunotherapy has shown benefit in many tumor types, including SCLC. In preclinical and clinical studies of solid tumors, co-inhibition of T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitor motif domains (TIGIT) and PD-1 enhanced antitumor activity of anti-PD-1. AdvanTIG-204 (NCT04952597) investigated the efficacy and safety of ociperlimab + tislelizumab + cCRT in patients with untreated limited-stage SCLC. Methods: Patients with limited-stage SCLC and no prior systemic therapy were randomized 1:1:1 to Arm A (ociperlimab [900 mg IV Q3W] + tislelizumab [200 mg IV Q3W] + cCRT for 4 cycles, then ociperlimab + tislelizumab), Arm B (tislelizumab + cCRT for 4 cycles, then tislelizumab), or Arm C (cCRT for 4 cycles). Study drugs (Arms A and B) were continued for up to 12 months or until progression, unacceptable toxicity, or withdrawal. Primary endpoint: investigator-assessed PFS per RECIST v1.1. Secondary analyses included additional efficacy and safety endpoints in the ITT population, and efficacy in patient subgroups by PD-L1 and TIGIT expression (both <1% vs ≥1%), using tumor area positivity (PD-L1) and immune cell scoring (TIGIT). No hypothesis testing was predefined (p-value for descriptive purposes only). Descriptive comparisons were conducted for Arm A vs C, B vs C, and A vs B. Results: As of July 26, 2023, 126 patients (median age, 61.5 years) were randomized to Arm A (n=41), Arm B (n=42), or Arm C (n=43). Median follow-up: ~18 months (all arms). There was a trend of improvement in median PFS in Arm A (12.6 months) and Arm B (13.2 months) vs Arm C (9.5 months); HR (95% CI): Arm A vs C, 0.84 (0.46-1.52; p=0.2793); Arm B vs C, 0.80 (0.45-1.44; p=0.2414). ORR was 85.4% (3 CR) in Arm A, 88.1% (4 CR) in Arm B, and 76.7% (1 CR) in Arm C. Median DoR was 10.1 months in Arm A, 11.5 months in Arm B, and 8.2 months in Arm C. Median OS was not reached in any arm. Analyses showed that PD-L1 or TIGIT expression did not correlate with efficacy, however, small subgroup size limits interpretability. All patients experienced ≥1 treatment-related adverse event (TRAE); rates of grade ≥3 TRAEs were 73.2%, 78.6% and, 65.1% in Arms A, B, and C, respectively. The most common TRAEs included anemia (80.5% in Arm A vs 83.3% in Arm B vs 81.4% in Arm C), nausea (80.5% vs 76.2% vs 65.1%), and WBC count decreased (78.0% vs 76.2% vs 62.8%). Rates of TRAEs leading to any treatment discontinuation were 26.8%, 21.4%, and 4.7% in Arms A, B, and C, respectively. One patient in each arm experienced a TRAE leading to death. Conclusion: In patients with untreated limited-stage SCLC, tislelizumab + cCRT yielded a trend of improvement in PFS and ORR vs cCRT; addition of ociperlimab did not show detectable improvement. The overall safety profile of the treatments was tolerable, manageable, and generally consistent with the known risks of ociperlimab, tislelizumab, and cCRT. Citation Format: Youling Gong, Qingsong Pang, Rong Yu, Zhengfei Zhu, Jiangqiong Huang, Yufeng Cheng, Diansheng Zhong, Hongbo Wu, Seung Soo Yoo, Tracy Dobbs, Zinan Bao, Yunxia Zuo, Boxian Wei, Pu Sun, You Lu. AdvanTIG-204: A phase 2, multicenter, randomized, 3-arm, open-label study investigating the preliminary efficacy and safety of ociperlimab (anti-TIGIT) + tislelizumab (anti-PD-1) + concurrent chemoradiotherapy (cCRT) in patients with untreated limited-stage small cell lung cancer (SCLC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT255.

The paper is the first of a series, which aims to present a consistent interpretation of the suprageneric taxa of fossil beetles in the current century and their generic and species composition. Order Coleoptera is considered in composition of the superorder Coleopteroidea Handlirsch, 1903 (= Coleopterida sensu Boudreaux, 1979, nec Pearse, 1936) together with orders Skleroptera and Strepsiptera, and also with the family Umenocoleidae of unclear position. This paper includes the archostematan superfamilies Coleopseoidea and Cupedoidea of the infraorder Cupediformia, i.e., Coleopseidae (one genus and one species), Tshekardocoleidae (12 genera, 15 species), Labradorocoleidae (one genus, one species), Permocupedidae (together with Taldycupedinae, stat. nov., 24 genera and 54 species) and Cupedidae (three subfamilies, 49 genera, 253 species). The preliminary information on structure of the larva of Tshekardocoleidae from Tshekarda is done. There are also described the new taxa: genus Afrotaldycupes Kirejtshuk, gen. nov. with the type species: genus Taldycupes africanus Ponomarenko in Ponomarenko & Mostovski, 2005 [Afrotaldycupes africanus comb. nov.] and Afrotaldycupes lidgettoniensis (Ponomarenko in Ponomarenko & Mostovski, 2005), comb. nov. [Taldycupes]; genus Allophalerus Kirejtshuk, gen. nov. with the type species: Tetraphalerus aphaleratus Ponomarenko, 1969 [Allophalerus aphaleratus comb. nov.], and also with Allophalerus antiquus (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Allophalerus bontsaganensis (Ponomarenko, 1997), comb. nov. [Tetraphalerus], Allophalerus incertus (Ponomarenko, 1969), comb. nov. [Tetraphalerus], Allophalerus latus (Tan, Ren et Shih, 2007), comb. nov. [Tetraphalerus], Allophalerus maximus (Ponomarenko, 1968), comb. nov. [Tetraphalerus], Allophalerus okhotensis (Ponomarenko, 1993), comb. nov. [Tetraphalerus], Allophalerus tenuipes (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Allophalerus verrucosus (Ponomarenko, 1966), comb. nov. [Tetraphalerus]; genus Bukhkalius Kirejtshuk et Jarzembowski, gen. nov. with the type species: Tetraphalerus lindae Jarzembowski, Wang et Zheng, 2017 [Bukhkalius lindae comb. nov.]; genus Burmocoleus Kirejtshuk, gen. nov. with the type species: Burmocoleus prisnyi sp. nov. and Burmocoleus zhiyuani (Liu, Tan, Ślipiński, Jarzembowski, Wang, Ren et Pang, 2017), comb. nov. [Brochocoleus]; genus Cionocups Kirejtshuk, gen. nov. with the type species: Cionocups manukyani sp. nov.; genus Echinocups Kirejtshuk et Jarzembowski, gen. nov. with the type species: Notocupes neli Tihelka, Huang et Cai, 2020 [Echinocups neli comb. nov.], and also Echinocups ohmkuhnlei (Jarzembowski, Wang et Zheng, 2020), comb. nov. [Notocupes] and Echinocups denticollis (Jiang, Li, Song, Shi, Liu, Chen et Kong, 2020), comb. nov. [Notocupes]; genus Jarzembowskops Kirejtshuk, gen. nov. with the type species: Brochocoleus caseyi Jarzembowski, Wang et Zheng, 2016 [Jarzembowskops caseyi comb. nov.]; genus Lobanovia Kirejtshuk, gen. nov. with the type species: Simmondsia permiana Ponomarenko, 2013 [Lobanovia permiana comb. nov.]; genus Pintolla Kirejtshuk, gen. nov. with the type species: Kaltanicupes ponomarenkoi Pinto, 1987 [Pintolla ponomarenkoi comb. nov.]; genus Polyakius Kirejtshuk, gen. nov. with the type species: Polyakius alberti Kirejtshuk, sp. nov. and Polyakius pubescens Kirejtshuk, sp. nov.; Clessidromma zengi Kirejtshuk, sp. nov.; Cupes golovatchi Kirejtshuk, sp. nov.; Cupes legalovi Kirejtshuk, sp. nov.; Cupes lutzi Kirejtshuk, sp. nov.; Cupes nabozhenkoi Kirejtshuk, sp. nov.; Cupes wedmannae Kirejtshuk, sp. nov.; Mallecupes prokini Kirejtshuk, sp. nov. and Omma janetae Kirejtshuk, sp. nov. The new synonymy is established for the generic names Clessidromma Jarzembowski, Wang et Zheng, 2017 and Lepidomma Jarzembowski, Wang et Zheng, 2019, syn. nov. The rank of Cainomerga A. Kirejtshuk, Nel et P. Kirejtshuk, 2016 is elevated from subgeneric to generic. Also other new combinations are proposed: Cainomerga brevicornis (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Cainomerga fraterna (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Cainomerga immaculata (Piton, 1940: 194), comb. nov. [Zonabris, Mesocupes], Cainomerga palaeocenica (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], and Cainomerga ponti (A. Kirejtshuk, Nel et P. Kirejtshuk, 2016), comb. nov. [Mesocupes], Clessidromma tianae (Jarzembowski, Wang et Zheng, 2019), comb. nov. [Lepidomma], Diluticupes applanatus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes crowsonae (Jarzembowski, Yan, Wang et Zhang. 2013), comb. nov. [Brochocoleus], Diluticupes magnus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes minor (Ponomarenko, 2000), comb. nov. [Brochocoleus], Diluticupes validus (Tan et Ren, 2009), comb. nov. [Brochocoleus], Diluticupes yangshuwanziensis (Jarzembowski, Yan, Wang et Zhang. 2013), comb. nov. [Brochocoleus], Monticupes curtinervis (Tan, Ren et Shih, 2007), comb. nov. [Tetraphalerus], Monticupes decorosus (Tan, Wang, Ren et Yang, 2012), comb. nov. [Tetraphalerus], Odontomma sulcatum (Tan, Ren et Shih, 2007), comb. nov. [Brochocoleus], Omma ancistrodontum (Tan, Wang, Ren et Yang, 2012), comb. nov. [Pareuryomma], Omma grande (Ponomarenko, 1964), comb. nov. [Tetraphalerus], Omma longicolle (Ponomarenko, 1997), comb. nov. [Tetraphalerus], Pareuryomma angustum (Tan, Ren et Shich, 2007), comb. nov. [Brochocoleus], Pareuryomma magnum (Tan et Ren, 2009), comb. nov. [Brochocoleus], Zygadenia aliena (Tan et Ren, 2006), comb. nov. [Ovatocupes], Zygadenia baojiatunensis (Hong 1992), comb. nov. [Chengdecupes], Zygadenia brachycephala (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia caduca (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia caudata (Ponomarenko, 1966), comb. nov. [Notocupes], Zygadenia cellulosa (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia crassa (Ponomarenko, 1969), comb. nov., [Notocupes], Zygadenia cyclodontus (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia dischdes (Zhang, 1986), comb. nov. [Notocupes], Notocupes dundulaensis (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia elegans (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia epicharis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia eumeura (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia excellens (Ponomarenko, 1966), comb. nov. [Notocupes], Zygadenia exigua (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia foersteri (Ponomarenko, 1971), comb. nov. [Procarabus, Notocupes], Zygadenia homora (Lin, 1986), comb. nov. [Conexicoxa, Notocupes], Zygadenia issykkulensis (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia jurassica (Hong 1983), comb. nov. [Chengdecupes], Zygadenia kezuoensis (Hong 1987), comb. nov. [Chengdecupes], Zygadenia khasurtuiensis (Strelnikova, 2019), comb. nov. [Notocupes], Zygadenia khetanensis (Ponomarenko, 1993), comb. nov. [Notocupes], Zygadenia kirghizica (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia laeta (Lin, 1976), [Tetraphalerus], Zygadenia laiyangensis (Hong et Wang, 1990), comb. nov. [Forticupes, Notocupes], Zygadenia lapidaria (Ponomarenko, 1968), comb. nov. [Notocupes], Zygadenia laticella (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia lata (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia lenta (Ren, Lu, Guo et Ji, 1995), comb. nov. [Tetraphalerus], Zygadenia lini (Ponomarenko, Yan, Wang et Zhang, 2012), comb. nov. [Notocupes], Zygadenia longicollis (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia ludongensis (Wang et Liu, 1996), comb. nov. [Notocupes], Zygadenia minuscula (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia mongolica (Ponomarenko, 1994), comb. nov. [Notocupes], Zygadenia nigrimonticola (Ponomarenko, 1968), comb. nov. [Notocupes], Zygadenia oxypyga (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia patula (Ponomarenko, 1985), comb. nov. [Notocupes], Zygadenia pingi (Ponomarenko et Ren, 2010), comb. nov. [Notocupes], Zygadenia porrecta (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygadenia protensa (Tan, Ren, Shih et Ge, 2006), comb. nov. [Amblomma, Notocupes], Zygodenia psilata (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], , Zygadenia pulchra Ponomarenko, 1968, comb. nov. [Notocupes], Zygadenia reticulata (Oppenheim, 1888), comb. nov. [Procarabus, Notocupes], Notocupes rostrata (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia rudis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia shiluoensis (Hong 1984), comb. nov. [Chengdecupes], Zygadenia sogutensis (Ponomarenko, 1969), comb. nov., Zygadenia stabilis (Tan, Ren et Liu, 2005), comb. nov. [Amblomma, Notocupes], Zygadenia tenuis (Ponomarenko, 1969), comb. nov. [Notocupes], Zygadenia tripartita (Oppenheim, 1888), comb. nov. [Procarabus, Notocupes], Zygadenia tuanwangensis (Hong et Wang, 1990), comb. nov. [Picticupes, Notocupes], Zygadenia valida (Lin, 1976), comb. nov. [Sinocupes, Notocupes], Zygadenia vitimensis (Ponomarenko, 1966), comb. nov. [Notocupes].

The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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LANGUAGE NOTE | Document text in Chinese; abstract also in English. 魯迅(1881-1936)是我國現代小説重要的開拓者。他的小説，無論內容、形式、技巧，都突破傳統小説的規範，尤其敍述技巧方面，勇於作種種新的嘗試。他借鑑了西方的敍事觀點理論，靈活變化運用：每一種敍事觀點都加以試驗，相同的敍事觀點又加以變化運用，做成每一篇作品都有不同的形式。 《吶喊》和《彷徨》是魯迅創作小説的結集。本文就兩部小説集中二十五篇小説，逐一分析其敍述技巧；而所謂敍述技巧，主要是敍事觀點的選擇、運用，有時旁及敍述時間的操縱、調度。Lu Xun (1881-1936) is an important pioneer of Chinese modem fiction. The content, format, techniques of his novels are also breakthroughs to the canonical of traditional Chinese novels. He also made new attempts in his narrative techniques. He used the experience of the narrative viewpoint theory from the western novels and handled them with great flexibility. He experimented on each of the narrative viewpoint and applied them quick-wittedly on the same narrative viewpoint so that each piece of the novels has a different modality. "Cry Out” ('Na Han') and "Wandering" (‘Pang Wang') are the two collections of short novels of Lu Xun. This passage focuses on the analysis of the narrative viewpoints of the twenty five masterpieces one by one. The so-called narrative techniques are mainly the choice of narrative viewpoint. He might sometimes takes interest in the control and management of narrative time as well.

碩士
雲林科技大學
漢學資料整理研究所碩士班
96
Lu Xun was a Chinese writer, who published the first Chinese modern short story collection "A Madman''s Diary" in New Youth during the Five Fourth Movement, which strongly shocked many readers. And afterwards Lu Xun published many other short stories, all of them were collected in "Na Han" and "Pang Huang" and both of which gave huge influences on the development of the Five Fourth Movement and New Literature Movement. Arthur Henderson Smith（1845—1932）was an American missionary. Because of the needs of missionary work, he had to enter the world of the country, therefore, he had detailed and deep observation on Chinese characteristics, and wrote down the book “ Chinese Characteristics”. Lu Xun ever read “Chinese Characteristics” while studied in Jupan, and the content and topic of “Na Han" and "Pang Huang" also encircled the issue “national spirit”. Are Arthur Henderson Smith’s opinions either pejorative bias or penetrating insight? And why does Lu Xun’s story make people relish it again and again? Is the “national spirit” presented among those pieces either Lu Xun’s intentional depiction for exposing such spiritual ills or the real picture of his personal experiences? One was a Chinese writer and the other was an American missionary, both of them had their own grounds and views on Chinese natioanl spirit. About their similarities and dissimilarities, we hope to provide some references by the study.

博士
國立高雄師範大學
國文學系
104
The Concept of “Screaming” in Lu Xun’s novels were derived from the origins of revolutionary spirit, female autonomy, and native belief. The external revolution had been deepened into the internal one, which carried out the spirit of the Enlightenment into female autonomy, and eventually found strength of purity and stability in the native belief. In Call to Arms (Na han) and Wandering (Pang huang), we can see that the category of “Moro Poet” had taken Lu Xun as its creative prototype, that is, the imperfect intellectuals, the roles of women endeavouring to survive, and some seemingly ordinary nobodies, etc. From the struggling hardships they encountered and from the real inner voices of the characters, we see that the concept of “screaming” can be interpreted as “to compromise between ideal and reality,” “to find truth of life in irony and sarcasm,” “to self-identify and explore the significance of being,” “to affirm human desires and awake to self-discipline,” and “to redeem beauty and confess to strive,” etc. The characters in Call to Arms (Na han) and Wandering (Pang huang) often have sharp and distinct personalities which can be perceived from the descriptions of the relations between group and individual in the ongoing situations in the novels. These characters possess the poetic and vigorous styles of Wei and Jin dynasties, and they reveal unintentionally some rebellious complexes. All these happen to be the characteristics of Western expressionists. The plot and the lives of characters, arranged under the negative and tragic struggle and selection, seemed to point to an internal revolution in Lu’s mind, which had to be rooted in the land of truth and being, and be activated by the strength of inner stability or the combination of love and wisdom. After the individual enlightenment, one recognizes that happiness does not come in mere imagination. One has to seek a balance between ideal and reality, and he has to establish a bridge to communicate between and groups and the autistic self. The internal revolution has to be coordinated and synchronized with that of the external. This is the real and progressive purpose of life illustrated in the idea of “establishing oneself and helping others in establishment” in Lu Xun’s thoughts.

Chapter One examines pastiche in the shopping mall and cultural heritage site Xintiandi, before discussing the site’s buried modern art histories marred by cross-cultural conflicts. Xintiandi physically surrounds China’s first communist meeting site of 1921, today memorialized as a museum. The complex was designed with reference to the vernacular homes of its formerly foreign occupied French Concession setting, and is officially celebrated for its “East-meets-West” and “Old-meets-New” architecture, even while the construction demolished most of the site’s existing homes and dislocated thousands of working class residents. This chapter analyzes how Xintiandi’s seemingly benign East-meets-West façades mask collusions between the Chinese Communist Party’s autocratic state power and capitalist development, while romanticizing Shanghai’s modern cosmopolitan legacy. The chapter analyzes examples of Xintiandi’s repressed cultural histories, including the revolutionary art and design experiments of Pang Xunqin, founder of the 1930s avant-garde collective, The Storm Society, leftist writings and art promoted by Lu Xun, and the major Cultural Revolution Era debate sparked by Michelangelo Antonioni’s 1972 documentary, Chung Kuo Cina. The chapter argues that the official admonishment of Shanghai-based cultural projects by Pang and Antonioni speak to collisions between Shanghai’s semi-colonial past, Maoist socialism, and Cultural Revolution Era totalitarianism that still resonate in Shanghai today.