Dissertations / Theses: 'PanIN'

1

Distler, Marius, Daniela E. Aust, Jürgen Weitz, Christian Pilarsky, and Robert Grützmann. "Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-147337.

Full text

Abstract:

Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.

APA, Harvard, Vancouver, ISO, and other styles

2

Hamidi, Tewfik. "La protéine de stress p8 permet l'adaptation des cellules cancéreuses pancréatiques aux conditions microenvironnementales extrêmes. : Etude de ses mécanismes d'action." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4100.

Full text

Abstract:

La protéine de stress p8 fut découverte et caractérisée dans notre laboratoire. Cette protéine est surexprimée dans l'adénocarcinome pancréatique et possède un rôle dans la progression tumorale. Pendant ce travail de thèse, nous nous sommes focalisé sur le rôle de p8 dans les phases initiales de la tumorigénèse pancréatique et sur ses mécanismes d'action, impliqués dans la progression tumorale. Nous avons montré que p8 joue un rôle essentiel dans l'apparition des lésions PanINs suite à l'activation de l'oncogène Kras. Au niveau cellulaire, nous avons montré que la protéine p8 protège les cellules tumorales pancréatiques contre le stress de la privation en nutriments via la régulation de l'expression de RelB et IER3. La voie p8, RelB et IER3 est impliquée dans l'inhibition de l'apoptose suite au stress. De plus, nous avons observé que ces trois protéines sont co-exprimées dans les adénocarcinomes humains et leur expression corrèle avec l'évolution de la maladie. Dans un second lieu, nous avons démontré le rôle essentiel de la protéine p8 dans la résistance des cellules tumorales pancréatiques à l'hypoxie et à la privation en glucose. Nous avons identifié la voie p8/Aurora KinaseA, qui en réponse au stress métabolique, réduit l'apparition des dommages à l'ADN en contrôlant l'expression des gènes liés au cycle cellulaire et à la réparation de l'ADN. De plus, nos recherches ont montré que p8 protège les cellules tumorales du stress métabolique en inhibant la mort cellulaire dépendante de l'autophagie. Nous espérons que nos résultats aideront à mieux cibler les cellules tumorales pancréatiques et leur caractère résistant au stress micro-environnemental extrême
The stress protein p8 was discovered and characterized in our laboratory. Over expressed in pancreatic adenocarcinoma, p8 is involved in tumor progression. During my PhD studies, we focused on the role of p8 in pancreatic cancer development and on its mechanisms of action. First, we demonstrated that p8 is essential for PanIN development following Kras oncogene activation. At the cellular level, we found that p8 protects pancreatic cancer cells upon nutrient starvation stress through the regulation of RelB and IER3 expression. p8, RelB and IER3-dependent cascade inhibits apoptosis after the starvation stress. Furthermore, we showed that these tree proteins are co expressed in human pancreatic adenocarcinoma. One the other hand, our study showed that p8 is involved in pancreatic cancer cells resistance to hypoxia and glucose starvation. We identified a p8/Aurora KinaseA pathway which, in response to such metabolic stress, reduces DNA damage by regulating cell cycle and DNA repair genes expression. Moreover, our studies demonstrated that p8/AURKA path protects cancer cells against metabolic stress by inhibiting autophagy-associated cell death. We expect that our data will help to get new therapeutics against pancreatic cancer

APA, Harvard, Vancouver, ISO, and other styles

3

Serwaah-Panin, Amma [Verfasser], Dorothea [Gutachter] Kübler, and Ferdinand [Gutachter] Vieider. "Experiments in risk, insurance and development / Amma Serwaah-Panin ; Gutachter: Dorothea Kübler, Ferdinand Vieider." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1164076337/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Tsuda, Motoyuki. "The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis." Kyoto University, 2019. http://hdl.handle.net/2433/242378.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Salcedo, Allende Maria Teresa. "Neoplasia intraepitelial pancreática y adenocarcinoma ductal de pancreas: estudio de factores de las vías de señalización celular y su correlación con la clínica." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/377763.

Full text

Abstract:

El adenocarcinoma ductal pancreático (ADP) constituye aproximadamente el 85% de los tumores del páncreas. Es el tumor en el que menos avances clínicos se han producido en los últimos 50 años y sigue teniendo un pronóstico muy malo. Por ello, es necesaria la identificación de factores de riesgo y la caracterización del proceso de progresión tumoral, así como la identificación de nuevas dianas terapéuticas. En esta Tesis Doctoral estudiamos el estado de las vías de señalización celular en una serie de ADP convencionales, así como en ductos de pancreatitis crónicas (PC) y las lesiones precursoras asociadas (PanIN). El objetivo principal del presente trabajo es el estudio inmunohistoquímico y molecular de diversos factores implicados en las vías de señalización celular y de transición epitelio-mesénquima (PI-3K-AKT-mTOR, Ras-Raf-MAPK, Hippo, p53, N-cadherina y p16), con el objetivo de poder definir un modelo de progresión desde lesiones de PanIN en PC a ADP infiltrante , así como demostrar la relación de los niveles de expresión de dichos factores con una serie de parámetros clínico-patológicos con valor pronóstico, estado mutacional y supervivencias, en el ADP. Los resultados del estudio de nuestra serie validan, por una parte, los criterios establecidos como factores con valor pronóstico: tamaño tumoral, margen quirúrgico afecto (R1), invasión vascular, invasión linfática, invasión perineural, metástasi hepáticas y estadios avanzados. En relación al modelo de progresión PanIN-ADP, demostramos que existe un aumento en la expresión de la gran mayoría de proteínas estudiadas desde su expresión en ductos de PC y la expresión en ADP. Asimismo, porponemos un valor de Ki67 ≥ a 20% como biomarcador útil a la hora de discernir entre proliferación ductular reactiva o ADP bien diferenciado en las biopsias pequeñas o en los márgenes quirúrgicos de piezas de resección. En relación al estudio genético de RAS, confirmamos que ningún caso presenta mutación para NRAS, a diferencia del 89% de los ADP, que presentan mutaciones de KRAS, y que la presencia de dicha mutación implica peor pronóstico. En cuanto a los factores de señalización celular en ADP, se confirma que la expresión de algunas proteínas (p4E-BP1, eIF4E y YAP1) se asocia a factores de mal pronóstico y peor supervivencia. No evidenciamos en el estudio relación significativa entre la expresión de las proteínas estudiadas con parámetros clínico-patológicos relacionados con estroma peritumoral (p16, desmoplasia, inflamación). Nuestros resultados concluyen que el estudio de los factores de las vías de señalización celular complementan el estudio anatomopatológico de los ADP. La determinación de Ki67 con un valor superior a 20% permite discernir entre una proliferación ductular reactiva/metaplasia acinar ductal y ADP bien diferenciado y lo proponemos como marcador a la hora de valorar margen quirúrgico de piezas de resección y biopsias pequeñas. La sobreexpresión de YAP1 nuclear, eIF4E citoplasmático y p4E-BP1 nuclear definen un perfil molecular de ADP de peor pronóstico. Finalmente, resaltar la relevancia de caracterizar factores asociados al microambiente que rodea al ADP e influyan en el comportamiento biológico de los mismos. El grupo de tumores sin mutaciones de KRAS y NRAS es muy interesante de cara a identificar otras eventuales alteraciones moleculares, con incidencia en el desarrollo de los ADP. La intención en un futuro es ampliar la serie para conseguir resultados significativos que permitan obtener más conclusiones.
Pancreatic ductal adenocarcinoma (ADP) constitutes approximately 85% of pancreatic tumors. It is the tumor in which fewer clinical developments have occurred in the last 50 years and continues to have a very poor prognosis. Therefore, the identification of risk factors and characterization of tumor progression, as well as the identification of new therapeutic targets is necessary. In this Thesis we studied the state of the cell signaling pathways in a number of conventional ADP as well as ducts of chronic pancreatitis (CP) and the associated precursor lesions (PanIN). The main objective of this paper is the study of various factors involved in cell signaling pathways and epitelio-mesenchymal transition (PI-3K-AKT-mTOR, Ras-Raf-MAPK, Hippo, p53, N-cadherin and p16) by immunohistochemical and molecular study, with the aim to define a model of progression from precursor lesions of PanIN in PC to infiltrating ADP; and to demonstrate the relationship of the expression levels of these factors with a series of pathological parameters with prognostic value, mutational state and survival in the ADP. The survey results of our series validate the established prognostic criteria factors: tumor size, surgical margin affection (R1), vascular invasion, lymphatic invasion, perineural invasion, progression to liver metastasis and advanced stages. Regarding the progression model PanIN-ADP show an increased expression of the vast majority of proteins studied since its expression in ducts of PC to ADP expression. Also, we propose a value of Ki67 ≥ 20% as useful biomarker to discern between a benign reactive ductular proliferation/acinar ductal metaplasia and a well differentiated ADP in small biopsies or in surgical margins of resected specimens. In relation to genetic study of RAS, we confirm that no event has mutation to NRAS, unlike the 89% of ADP showing KRAS mutations, and the presence of said mutation confers decreased survival. As for cell signaling factors in ADP, it is confirmed that the expression of some proteins (p4E-BP1, eIF4E and YAP1) factors associated with poor prognosis and shorter survival. No we show in the study significant relationship between the expression of the proteins with pathological parameters related to peritumoral stroma (p16, desmoplasia, inflammation). Our results conclude that the study of the factors of cellular signaling pathways complement the pathological report of the ADP. Ki67 determining a value greater than 20% can discern between a benign reactive ductular proliferation and a well differentiated ADP and propose it as a marker in assessing surgical resection margin and small biopsies. Overexpression of YAP1 nuclear, eIF4E cytoplasmic and p4E-BP1 nuclear define a molecular profile of ADP with worse prognosis. Finally, highlight the importance of characterizing factors associated with ADP microenvironment and their influence on biological behavior. The group of tumors without KRAS mutations and NRAS is very interesting in order to identify other molecular alterations, with impact on the development of ADP. The intention in the future is to expand the series to achieve significant results that allow more conclusions.

APA, Harvard, Vancouver, ISO, and other styles

6

Panin, Valerii [Verfasser], Thomas [Akademischer Betreuer] Aumann, and Joachim [Akademischer Betreuer] Enders. "Fully exclusive measurements of quasi-free single-nucleon knockout reactions in inverse kinematics. / Valerii Panin. Betreuer: Thomas Aumann ; Joachim Enders." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2012. http://d-nb.info/1106257030/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

DeVeaugh-Geiss, Angela Marie West Suzanne L. "Depression and comorbid panic and pain in primary care patients." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1734.

Full text

Abstract:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.
Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the Doctor of Philosophy of Epidemiology in the School of Public Health." Discipline: Epidemiology; Department/School: Public Health.

APA, Harvard, Vancouver, ISO, and other styles

8

Schmahl, Michelle Jordan. "Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Martínez, Romero Carles. "Polycomb group proteins Bmi1 and Ring1B are involved in cell plasticity and tumorigenesis of the pancreas." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7190.

Full text

Abstract:

L'adenocarcinoma ductal pancreàtic (PDAC) és un dels càncers més letals. Per tal de millorar el diagnòstic precoç, s'estan investigant les etapes inicials de la formació del càncer, com és el cas de les lesions preneoplàstiques, i es vol desxifrar l'origen cel·lular de la malaltia. Les proteïnes Polycomb constitueixen una família de silenciadors epigenètics que es troben en una varietat de tumors sòlids. La hipòtesi principal és que Polycomb pot estar participant en els processos preneoplàstics del pàncreas i en l'aparició i progressió del tumor. La expressió de Bmi1 i Ring1B fou analitzada durant el desenvolupament del pàncreas, en teixit pancreàtic de diferents models murins de la malaltia i en mostres humans de teixit pancreàtic. Es va dur a terme l'anàlisi del mecanisme de Bmi1 mitjançant models in vitro i induint la depleció de Bmi1. Bmi1 i Ring1B s'expressaren en precursors pancreàtics durant etapes primerenques del desenvolupament i en cèl·lules ductals i dels illots,
però no en els acins, en el pàncrees adult. Bmi1 s'induí en cèl·lules acinars durant lesió aguda, en lesions metaplàstiques acinoductals, en neoplàsies intraepitelials pancreàtiques (PanIN) i en PDAC. Ring1B s'incrementà significativament en PanINs de grau alt i en PDAC. La disminució dels nivells de Bmi1 en la línia cel·lular acinar canvià l'expressió dels enzims digestius pancreàtics. Aquests resultats suggereixen que Bmi1 i Ring1B podrien estar contribuint de diferent manera en la progressió tumoral.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. To improve early diagnosis, research efforts are focused in characterising early events of cancer formation like preneoplastic lesions and deciphering the cell origin of the malignancy. Polycomb proteins constitute a family of epigenetic silencers found in a variety of solid tumours. The main hypothesis is that Polycomb might play a role in preneoplastic states in the pancreas and in tumour development and progression. The expression of Bmi1 and RingB was analysed during pancreatic development, in pancreatic tissue from mouse models of disease and in human pancreatic tissue samples. Mechanistic insights of Bmi1 were performed using in vitro models and with induced Bmi1 depletion. Bmi1 and Ring1B were expressed in pancreatic exocrine precursors during early development and in ductal and islet cells, but not in acinar cells, in the adult pancreas. Bmi1 was induced in acinar cells during acute injury, in acinar-ductal metaplastic lesions, in pancreatic intraepithelial neoplasia (PanIN) and PDAC. In contrast, Ring1B was significantly increased in high-grade PanINs and in PDAC. Bmi1 knockdown in acinar cell line changed the expression of pancreatic digestive enzymes. These results suggest that Bmi1 and Ring1B could contribute differently to tumour development.

APA, Harvard, Vancouver, ISO, and other styles

10

Bustamante, Mirayo Antonio. "Pain Diary : Pain Management Platform." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177259.

Full text

Abstract:

In the context of current human diseases and conditions, chronic pain is among the most typical reasons for seeking medical attention and is seen in 20 to 50 percent of patients attending primary care (Bajwa Z. H., 2012). With those figures in hand, the medical specialty of pain is of increasing interest to the scientific community and other parties involved in the management of chronic diseases. In the practical sense, chronic pain patients usually have, as of now, regular check-up appointments with their pain specialist, where medication is modified or maintained depending on the frequency and intensity of the patient’s pain episodes. As a matter of fact, between appointments, patients are usually encouraged to write a comprehensive account of their pain episodes and their characteristics in the form of a pain diary. In such diary, they write the intensity of their pain in a relative scale from 1 to 10, the location of the pain in their body, and other relevant comments, namely medication side-effects or the activity they were performing when pain appeared. This set of data is then used by pain specialists to calibrate the patient’s medication and follow their treatment. Pain Diary, the project developed and described in the present document, seeks a more flexible, precise approach for patients to record their pain diaries. The project emphasizes on the interaction between the patient and an electronic pain diary, in the form of an application for the iOS platform. This document discusses the human-computer interaction analysis, usability tests, accessibility tests, and prototypes created to develop a comprehensive user-oriented solution for patients of cancer and other chronic diseases. Finally, the paper will present a functional prototype created for iOS, taking into account UX (user experience) design and interaction, as well as a RESTful back-end to consider in a future large scale implementation of the project.

APA, Harvard, Vancouver, ISO, and other styles

11

Peters, Madelon Louise. "Chronic pain and pain perception." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=8259.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Hamilton, Gia Renee. "Nonclinical panic: A useful analogue for panic disorder?" CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2155.

Full text

Abstract:

The objective of this study is to see if nonclinical panickers with unexpected panic attacks (NCPs-U) may be a more useful panic disorder (PD) analogue than nonclinical panickers with expected panic attacks (NCPs-E).

APA, Harvard, Vancouver, ISO, and other styles

13

Jylli, Leena. "Acute pain in pediatric patients : aspects of pain management and pain assessment /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-135-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Blackburn, Alison. "Living with pain or living in pain : narrative journeys with low back pain." Thesis, Northumbria University, 2011. http://nrl.northumbria.ac.uk/1536/.

Full text

Abstract:

This study used a qualitative method to focus on the perspectives, beliefs and expectations of low back pain sufferers. The research was undertaken within a hospital based pain clinic. In recent years low back pain research has proliferated, and the epidemiological evidence suggests that back pain is an increasing problem. Much attention has been paid to the impact of low back pain on the population, and to the increasing cost in economic and health terms. Biomedical and psychological evidence abounds to shape acute and chronic management of low back pain, but there is a dearth of information about the viewpoint of those suffering pain. This study attempted to bring the understanding of the back pain sufferer to the fore. Issues of quality of life, functional ability and the impact of back pain on their lifestyle were explored, along with the influence of contextual factors in relation to how back pain sufferers perceived themselves and how others perceived them. A narrative method was utilized to illuminate the journey with pain. Nine interviews were conducted, and the interpretation and presentation of the narratives generated was influenced by Ricoeur’s interpretative theory. Thematic analysis revealed that doctorability, agency, control, separation or acceptance of the pain and the concept of future life were key features within the narratives. The analysis highlighted that for the majority in this study pain arrived uninvited following a traumatic accident or incident, and back pain became a chronic condition. It was always unwanted and initially it was unexpected as the usual script for pain is one of a transient incapacity followed by recovery. It was precisely this deviation from the norm that resulted in difficulties for the people suffering the pain. Biographical differences did not appear to be identifiable in the themes discerned in the stories, nor in the overall structure.

APA, Harvard, Vancouver, ISO, and other styles

15

Jansaithong, Jarassri. "Northern Thai school-aged children pain experience : pain descriptions and pain management strategies /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7184.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Wessner, Mark Daren. "Face to face [panim ʼel panim] in Old Testament literature /." Theological Research Exchange Network (TREN), 1998. http://www.tren.com.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Wittchen, Hans-Ulrich, Agnes Nocon, Katja Beesdo, Daniel S. Pine, Michael Höfler, Roselind Lieb, and Andrew T. Gloster. "Agoraphobia and Panic." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100091.

Full text

Abstract:

Background: The relationship of panic attacks (PA), panic disorder (PD) and agoraphobia (AG) is controversial. The aim of the current study is to prospectively examine the 10-year natural course of PA, PD and AG in the first three decades of life, their stability and their reciprocal transitions. Methods: DSM-IV syndromes were assessed via Composite International Diagnostic Interview – Munich version in a 10-year prospective-longitudinal community study of 3,021 subjects aged 14–24 years at baseline. Results: (1) Incidence patterns for PA (9.4%), PD (with and without AG: 3.4%) and AG (5.3%) revealed differences in age of onset, incidence risk and gender differentiation. (2) Temporally primary PA and PD revealed only a moderately increased risk for subsequent onset of AG, and primary AG had an even lower risk for subsequent PA and PD. (3) In strictly prospective analyses, all baseline groups (PA, PD, AG) had low remission rates (0–23%). Baseline PD with AG or AG with PA were more likely to have follow-up AG, PA and other anxiety disorders and more frequent complications (impairment, disability, help-seeking, comorbidity) as compared to PD without AG and AG without PA. Conclusions: Differences in incidence patterns, syndrome progression and outcome, and syndrome stability over time indicate that AG exists as a clinically significant phobic condition independent of PD. The majority of agoraphobic subjects in this community sample never experienced PA, calling into question the current pathogenic assumptions underlying the classification of AG as merely a consequence of panic. The findings point to the necessity of rethinking diagnostic concepts and DSM diagnostic hierarchies.

APA, Harvard, Vancouver, ISO, and other styles

18

Manduch, Marosh. "Stimulation-evoked pain and temperature sensations in thalamus of pain and non-pain patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0006/MQ46163.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Grant, Nancy Anne Tully. "Pain measurement : validation of the Sensory Pain Questionnaire." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63861.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Boichat, Charlotte Sarah. "Anxiety-related pain constructs, attentional bias and pain." Thesis, University of Bath, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539551.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Osborn, Jody. "Pain generated by observation of others in pain." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1753/.

Full text

Abstract:

Recently, observation of pain has been linked to areas of the brain coding the sensory/discriminative aspects of pain (Avenanti et al., 2005; Avenanti et al., 2006). The experiential qualities associated with observing another in pain are poorly understood. In this thesis, we demonstrate that pain generated by observation of others in pain is reported by a significant minority of healthy individuals. The pain reported is mild, transient and occurs in the same location as the observed pain. Ten pain responders were matched with ten non-responders to take part in an fMRI study observing others in pain. Responders activated emotional and sensory brain regions associated with pain while the non-responders activated very little. Reports of pain were more likely to be accompanied by a pain memory. Pain responders are quicker to represent the perspective of others and have a more flexible sense of body ownership but are not more likely to report somatic symptoms during incongruent sensori-motor feedback. These findings provide convincing evidence that some people can readily experience pain during observation of others‘ pain. It is plausible that the mechanism underpinning pain reports evoked by observation of pain is not specific to pain processing per se.

APA, Harvard, Vancouver, ISO, and other styles

22

Frost, Michael. "Is pain still an issue in pain management?" Thesis, Bangor University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.483541.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Duinen, Marlies Alice van. "The stress of panic neuroendocrinological and neuroimmunological studies in panic disorder /." [Maastricht] : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 2005. http://arno.unimaas.nl/show.cgi?fid=6447.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Johansson, Angelika, and Martina Petersson. "Nätdroger : Moralisk panik eller verklig fara?" Thesis, Linnéuniversitetet, Institutionen för socialt arbete (SA), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-27504.

Full text

Abstract:

The aim of the study was to investigate whether the phenomenon of internet drugs should be considered as a moral panic or as a real danger. We have mainly focused on how society perceives young people's use of these drugs. The study is based on a qualitative approach and we have used structured interviews. The interviews were conducted with three different categories of professionals who in different ways have contact with parts of our study in their professional capacity. These are: officials, commentators, and researchers. We chose these respondents to get a chance to see the phenomenon from different perspectives. The study's starting point is moral panic and youth culture. The results and analysis section showed that the professionals had differing opinions on how to consider the phenomenon. The majority of respondents felt that there are elements of both moral panic and real danger; however, there were those who felt it was merely a moral panic, while others felt that it was solely a real danger. With this background, our conclusion is that probably internet drugs should be seen as both - a moral panic and a real danger.

APA, Harvard, Vancouver, ISO, and other styles

25

Nilsson, Madeleine. "Fångars anpassning i samhället : debatten i massmedia om anpassningen och dess anknytning till lagen." Thesis, Stockholm University, Department of Social Work, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-363.

Full text

Abstract:

Syftet med den här studien har varit att belysa hur fångars situation, med avseende på deras anpassning i samhället, uttrycks i massmedia samt hur de uttryckta föreställningarna om anpassning kan relateras till lagtexten. Studien är kvalitativ och den empiri som använts är debattartiklar i Dagens Nyheter och Svenska Dagbladet. Till dessa artiklar har följande frågeställningar ställts:

-Vilka förhållanden anses som problem i massmediala diskussioner beträffande fångarnas situation? Hur beskrivs dessa och vilka förslag till lösningar diskuteras?

-Hur kan sådana förhållanden relateras till fångarnas anpassning i samhället och hur kan den i sin tur kopplas till lagens intentioner?

Resultatet av den första frågeställningen har analyserats utifrån ett socialkonstruktivistiskt perspektiv och med hjälp av begreppen ”claims- maker”, ”socialt problem” och ”moralisk panik”. Den andra frågeställningen har analyserats med lagtext som utgångspunkt. Resultatet har även jämförts med tidigare forskning på området. Viktiga slutsatser har varit att de fångar som är mest isolerade från samhället också löper den största risken att inte bli föremål för återanpassningsinriktade åtgärder. Hög säkerhet och fångars anpassning i samhället kan även sägas stå i ett motsatsförhållande till varandra.

APA, Harvard, Vancouver, ISO, and other styles

26

Ankargård, Therese, and Malin Skilberg. "Ungdomars upplevelse av social medias risker och möjligheter." Thesis, Högskolan i Gävle, Socialt arbete, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-27421.

Full text

Abstract:

Sociala medier tar en allt större plats i ungdomars vardag, men hur stor plats tar den egentligen. Vi läser i media om hur allt fler ungdomar utsätts för övergrepp, kränkningar och mobbning via sina sociala medier. Vi vill genom vår studie visa hur några ungdomar själva resonerar kring sin användning av sociala medier. Vi vill även lyfta fram deras tankar kring risker och möjligheter som de själva kan se med sociala medier. Vi har intervjuat sju ungdomar från olika områden i Stockholm i åldrarna 15–19 år. Slutsatsen av studien är att ungdomarna kan se att det finns risker med sociala medier. De ser samtidigt att möjligheterna som finns med sociala medier, som till exempel att det är en snabb kommunikationskanal till deras kompisar både nära och långt bort, och att de även har tillgång till nyheter och information från hela världen, överväger riskerna.
Young people’s experience of social media’s risks and opportunities Social media is taking an ever-bigger place in the everyday life of young people, but how much space does it really take. We read in the media about how young people are being subjected to abuse, insults and bullying through their social media. Through our study, we want to show how some young people themselves argue about their use of social media. We also want to elevate their thoughts on the risks and opportunities they can see with social media. We have interviewed seven young people from different areas of Stockholm between the ages of 15-19 years. The conclusion of the study is that young people can see that there are risks with social media. At the same time, they see that the potential of social media, such as giving them a fast communication channel to their friends, both close and far away, and also having access to news and information from around the world, contemplates the risks.

APA, Harvard, Vancouver, ISO, and other styles

27

Miller, Andrew. "Ingenious pain." Thesis, Lancaster University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337550.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Hanson-Parkes, Jannae. "Chronic pain." Online version, 2002. http://www.uwstout.edu/lib/thesis/2002/2002hansonparkesj.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Almeida, Marina Barbosa de. "Imagining pain." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/94772.

Full text

Abstract:

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2011
Made available in DSpace on 2012-10-25T15:51:07Z (GMT). No. of bitstreams: 1 297994.pdf: 2120603 bytes, checksum: f399d37e8a1be779e659cfa014006b86 (MD5)
A presente tese reflete sobre maneiras de sermos afetados por representações de violência e sofrimento humano. A discussão parte da incapacidade do discurso midiático em sensibilizar sua audiência quando imagens violentas não são capazes de causar choque e empatia. Em contraste a estas representações, este estudo examina representações literárias e a experiência de leitura de narrativas que são temática e esteticamente violentas. O argumento segue a metodologia proposta por Marco Abel (2007) na qual a representação de eventos violentos é abordada em termos de sua força estética; em termos do potencial da literatura em suspender o significado e a verdade evitando, assim, a transformação da experiência da violência em uma representação da violência. As análises de Beloved (1987) de Toni Morrison, Push (1996) de Sapphire e The Dew Breaker (2004) de Edwidge Danticat ilustram como escritoras negras norte-americanas utilizam o recurso narrativo deferral of truth ("postergar a verdade"). Tal recurso carrega o potencial de subverter o conhecimento do leitor, trazer de volta sensação e oferecer a possibilidade de criarmos novos significados. Desta forma, estas narrativas de violência e dor tornam-se espaços de indeterminação e dúvida, mas também de imaginação, criatividade e reflexão.

APA, Harvard, Vancouver, ISO, and other styles

30

Sorrell, John T. "Effects of pain and fear stimulus intensity levels on pain responding in chronic pain patients." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1712.

Full text

Abstract:

Thesis (M.A.)--West Virginia University, 2000.
Title from document title page. Document formatted into pages; contains viii, 61 p. : ill. Includes abstract. Includes bibliographical references (p. 23-27).

APA, Harvard, Vancouver, ISO, and other styles

31

Anderson, Ruth. "Dancing in pain : pain appraisal and coping in dancers /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18372.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Norberg, Anna. "Genetics of pain : studies of migraine and pain insensitivity." Doctoral thesis, Umeå : Medical Biosciences Medicinsk biovetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-776.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Gradin, Maria. "Procedural pain reducing methods and pain assessment in newborns /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med868s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Nguyen, The Tung. "Un environnement pour le calcul intensif pain à pain." Phd thesis, Institut National Polytechnique de Toulouse - INPT, 2011. http://tel.archives-ouvertes.fr/tel-00657952.

Full text

Abstract:

Le concept de pair à pair (P2P) a connu récemment de grands développements dans les domaines du partage de fichiers, du streaming vidéo et des bases de données distribuées. Le développement du concept de parallélisme dans les architectures de microprocesseurs et les avancées en matière de réseaux à haut débit permettent d'envisager de nouvelles applications telles que le calcul intensif distribué. Cependant, la mise en oeuvre de ce nouveau type d'application sur des réseaux P2P pose de nombreux défis comme l'hétérogénéité des machines, le passage à l'échelle et la robustesse. Par ailleurs, les protocoles de transport existants comme TCP et UDP ne sont pas bien adaptés à ce nouveau type d'application. Ce mémoire de thèse a pour objectif de présenter un environnement décentralisé pour la mise en oeuvre de calculs intensifs sur des réseaux pair à pair. Nous nous intéressons à des applications dans les domaines de la simulation numérique et de l'optimisation qui font appel à des modèles de type parallélisme de tâches et qui sont résolues au moyen d'algorithmes itératifs distribués or parallèles. Contrairement aux solutions existantes, notre environnement permet des communications directes et fréquentes entre les pairs. L'environnement est conçu à partir d'un protocole de communication auto-adaptatif qui peut se reconfigurer en adoptant le mode de communication le plus approprié entre les pairs en fonction de choix algorithmiques relevant de la couche application ou d'éléments de contexte comme la topologie au niveau de la couche réseau. Nous présentons et analysons des résultats expérimentaux obtenus sur diverses plateformes comme GRID'5000 et PlanetLab pour le problème de l'obstacle et des problèmes non linéaires de flots dans les réseaux.

APA, Harvard, Vancouver, ISO, and other styles

35

Armstrong, Mary P. "Chronic low back pain : effectiveness of pain management programmes." Thesis, University of Ulster, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Galli, Ursula. "Stress and pain (dys)regulation in chronic orofacial pain." Göttingen Cuvillier, 2008. http://d-nb.info/99103158X/04.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Kappesser, Judith. "Pain judgements in other people investigating underestimation of pain /." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11759435.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

BRANDAO, MONICA CRISTINA DE CARVALHO CAMPIOLI. "SYSTEMIC LUPUS ERYTHEMATOSUS: PHYSICAL PAIN,PAIN OF THE SELF." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2003. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=4093@1.

Full text

Abstract:

COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
Focalizando o Lúpus Eritematoso Sistêmico como uma doença psicossomática, localizada no limiar entre o psíquico e o físico, esta dissertação pretende contribuir para o estudo do trauma, da dor psíquica e física, utilizando-se das teorias de Winnicott e Freud para este fim. Considerando que a dor física faz parte do quadro clínico do Lúpus Eritematoso Sistêmico, este trabalho levanta a questão de que o quadro álgico torna-se muitas vezes insuportável, por se somar à dor física, o eu que dói, decorrente de traumas vividos. O corpo adoecido e dolorido reclama a ausência de um meio ambiente bom o bastante levando a quebra na vivência de continuidade do ser, (Winnicott), assim como a ausência de uma barreira de estímulos (Freud) forte, que permita o desenvolvimento adequado do eu. Para ilustrar as idéias apresentadas no trabalho, foram retirados fragmentos dos relatos, realizados no ambulatório do Hospital Universitário Pedro Ernesto.
Focusing Systemic Erythematosus as a psychosomatic disease, located in the difficult thesrhold between the psychic and the physical, this dissertation intends to contribute for the study of the trauma, of psychic and physical pain, using the theories of Winnicott and Freud for this purpose. Considering that physical pain is part of the clinical picture of Systemic Lupus Erythematosus, this work raises the subject that of pain becomes many times unbearable, considering that to physical pain, pain of the self is odded, due to past, experienced traumas. The sick and aching body claims the break in the experience of the continuity of being, lock of a good enough environment (Winnicott), as well as lock of a strong stimuli barrier (Freud), allowing for on appropriate development of the self. To illustrate the ideas presented in this work, fragments of patients reports from the clinic of the University Hospital, Pedro Ernesto, were used for this purpose.

APA, Harvard, Vancouver, ISO, and other styles

39

Muir, R. "Living with chronic pain following a pain management programme." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2008410/.

Full text

Abstract:

Chronic pain is pain that has lasted for longer than six months (B.H. Smith, Elliott, & Hannaford, 2004) and has a wide ranging impact on individuals’ lives, affecting physical, social and psychological functioning (B. H. Smith et al., 2001). Despite the impact of chronic pain and the significantly increased use of healthcare (Von Korff, Wagner, Dworkin, & Saunders, 1991), the effectiveness of treatments for chronic pain are limited to a minority of individuals, whether of a medical or psychological orientation (Turk, 2005). One approach to chronic pain is through pain management programmes, which aim to increase individuals’ quality of life, psychological functioning and levels of activity (British Pain Society, 2007). Although previous reviews of the effectiveness of pain management programmes have concluded that such programmes are effective (Eccleston, Williams, & Morley, 2012; Flor, Fydrich, & Turk, 1992; Scascighini, Toma, Dober-Spielmann, & Sprott, 2008), these reviews have focussed on the short-term (less than 12 months) outcomes. Considering that such programmes do not ameliorate pain and that individuals will often experience pain for the rest of their lives there is a need for review of the long-term outcomes of these programmes. Paper one of this thesis is a review of the quantitative literature concerning long-term (greater than 12 months) psychological and quality of life outcomes of pain management programmes. Whilst quantitative research concerning chronic pain has focussed upon the shortterm effectiveness of psychological treatments, qualitative research has focused upon the experience of chronic pain prior to interventions (Hellström, 2001; J. A. Smith & Osborn, 2007; Toye et al., 2013). In particular, this research has highlighted themes relating to a changing understanding of individuals’ bodies and a threat to their identity (Hellström, 2001; Osborn & Smith, 2006; J. A. Smith & Osborn, 2007; Toye et al., 2013). As there is now greater certainty of the effectiveness of psychological approaches to chronic pain (Eccleston, Williams, & Morley, 2012) there is currently a shift away from studies of the effectiveness of interventions to a greater focus upon the mechanisms of change (McCracken & Marin, 2014; Morley, Williams, & Eccleston, 2013). Qualitative research of living with chronic pain following pain management programmes would inform both clinicians’ and researchers’ understanding of the experience of living with chronic pain after an intervention and therefore contribute to the development of this area of research. It would also help to contextualise psychological models of chronic pain (Hayes, Strosahl, & Wilson, 2004; Vlaeyen & Linton, 2000) within a phenomenological understanding (J. A. Smith, Flowers, & Larkin, 2009). The second paper of this thesis aims to provide a phenomenological account of the experiences of participants who have completed a pain management programme 12-36 months prior to participating in the research.

APA, Harvard, Vancouver, ISO, and other styles

40

Becker, Bettina. "Narratives of pain in old age : challenging 'ordinary' pain." Thesis, University of Winchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311849.

Full text

Abstract:

This thesis is based on narrative interviews with older people who live with pain and explores the meanings they develop. From their stories it emerged that constructions of ageing shape the meaning of pain. Pain is consequently constructed as `ordinary', non-disruptive pain that is a natural consequence of ageing. However, the narrators also developed alternative meanings. They constructed their pain as unique and disruptive, contested age-based definitions of their pain, and resisted medical intervention. The thesis explores the conflicts and contradictions that arise out of these multiple constructions.

APA, Harvard, Vancouver, ISO, and other styles

41

McCready, Marshall. "Putting the Panic Back in Moral Panic Theory: A Case for Disproportionality." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1752379/.

Full text

Abstract:

The appeal of moral panic studies, a once very popular sociological subfield, dropped precipitously around the turn of the century due in large part to debates about disproportionality, the notion a panicked group's concern about a perceived threat exceeds that warranted by its objective harmfulness. Classic theorists claim disproportionality is a panic's essential criterion and that it can be demonstrated by comparing a group's concerned reaction to the available facts. Critics argue it is a value-laden, ideologically tainted construct and often claim it cannot be demonstrated because there are no authoritative facts. These debates were and still are fraught with confusion. Perplexingly, both sides assume a shared definition despite clearly assessing the proportionality of different aspects of the relevant reaction. A typology differentiating the potential types of disproportionality either does not exist in the moral panic literature or remains shrouded in obscurity. In this paper, I review the classic theories, their critiques, and a new postmodern moral panic theory. By juxtaposing the different foci of the orthodox and contemporary theories, I derive a much-needed disproportionality typology. I also develop a new framework through which to assess moral panics predicated on this typology. My hope is these developments will stimulate a more sophisticated debate about disproportionality and encourage theorists to refine rather than simply reject classic approaches to the disproportionality problem.

APA, Harvard, Vancouver, ISO, and other styles

42

Kingsbury, Rachell. "Social pain theory : physical pain as a mediator of the relationship between social pain and defensiveness /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17731.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Warbrick, Tracy. "The effects of pain related anxiety on EEG correlates of pain perception and subjective pain responses." Thesis, Staffordshire University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438084.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Da, Costa Kathryn T. "The pain relief paradox : an investigation of the discrepancy between retrospective pain relief and pain intensity." Thesis, University of Hull, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252609.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Molen, Gerda Margo van der. "Panic, phobia and hypocapnia." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5608.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Burdová, Lucie. "Marketingový mix hotelu Panon." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2012. http://www.nusl.cz/ntk/nusl-223568.

Full text

Abstract:

This thesis focuses mainly on the analysis of marketing mix of hotel PANON, which offers accomodation in South Moravia in the town Hodonín in *** category in single, double and triple rooms as well as in apartments of different categories, catering services and a large number of additional services. The aim of this thesis is to make marketing mix of given hotel more efficient and thus ensure not only growth of existing number of guests, but also get new domestic and foreign guests, which will lead to growth of profit of the hotel PANON and strenghtening of its position in the tourism market.

APA, Harvard, Vancouver, ISO, and other styles

47

Kelly, Sioban Colette. "Structural and functional MRI studies of pain behaviour, selective attention and fear of pain in pain-free volunteers and chronic low back pain patients." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569583.

Full text

Abstract:

The aim of the original work presented in this thesis was to investigate morphological and functional differences in clinical and control populations, which may negatively impact the experience of pain. Firstly, morphological differences were investigated between groups of healthy controls and chronic low back pain (CLBP) patients. Included in the latter were subgroups of patients not previously investigated in the current morphological literature, those with and without pain behaviour. We investigated differences in gray matter (GM) volume between groups using an automated whole brain technique, and a manual method applied to two regions of interest, namely prefrontal cortex and insular cortex. A deficit in GM volume of right dorsal prefrontal cortex between CLBP patients and controls was found, with a further deficit in left insular cortex for CLBP patients with concomitant pain behaviour. Secondly, we conducted two studies using functional magnetic resonance imaging (fMRI) and a task of selective attention. Our initial investigation provided a proof of principle regarding the suitability of a semantic dot probe task within the fMRI environment. Pain-free participants were grouped based upon fear of pain scores. The results indicated differential behavioural and functional results between the groups. The thesis culminates with an fMRl study investigating selective attention in CLBP patients with pain behaviour. The clinical group were tested prior to and on completion of an intensive multidisciplinary pain management programme (PMP), with the aim of assessing if selective attention is sensitive to cognitive interventions. Selective attentional bias was demonstrated in the clinical group for pain-related trials at both testing sessions, although the direction of attention differed. Similarly, fMRI results showed differences in neural correlates for task performance between groups, with pre-PMP results demonstrating a reliance on semantic and memory processes. The fmdings suggest that fear of pain may be a vulnerability factor in the transition from acute to chronic pain and furthermore, CLBP patients with pain behaviour have structural, functional and behavioural differences which may negatively impact their ability to cope with their pain condition.

APA, Harvard, Vancouver, ISO, and other styles

48

Mechlin, Beth Girdler Susan S. "African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,679.

Full text

Abstract:

Thesis (M.A.)--University of North Carolina at Chapel Hill, 2006.
Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Psychology (Biological Psychology)." Discipline: Psychology; Department/School: Psychology.

APA, Harvard, Vancouver, ISO, and other styles

49

Gosden, Thomas. "Images of pain : exploration of the characteristics and functions of pain-related mental imagery in chronic pain." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2742.

Full text

Abstract:

Introduction A recent study by Potter et al. (in submission) reported that many chronic pain sufferers experience a spontaneous mental image of their pain, and that these individuals also report higher levels of anxiety and depression. However, little is known about the nature of pain-related mental imagery or the role it might have in chronic pain problems. Research Aims This project aimed to replicate these findings with a larger sample, and to discover more about the characteristics of pain-related mental imagery. It also aimed to explore the possible function of mental imagery in inducing physiological arousal and negative emotional reactivity. Methodology The research consisted of two discrete studies. In the first study, questionnaire measures of mental imagery, pain self-report, depression, anxiety, and use of imagery in everyday life were obtained from a naturalistic sample of chronic pain sufferers (N=105). The second study interviewed fourteen participants who reported experiencing pain-related mental imagery. These participants were also asked to intentionally generate their image and subjective measures of physiological and emotional reactivity were recorded. Results A significant proportion (40%) of participants reported experiencing pain-related mental imagery. Those who did also reported significantly higher levels of depression, though a trend towards higher levels of anxiety was not statistically significant. Mental images were predominately reported to be distressing, to occur frequently (at least every day), to interfere with daily living, to be longstanding (on average of three years duration), and to be largely stable over time. The majority of participants who were asked to intentionally self-generate their image during interview reported increases in physiological arousal and negative emotional reactivity. Discussion Experiencing a mental image of pain is a common phenomenon among chronic pain sufferers. Furthermore, the images experienced are long-standing, stable, and appear to be linked with physiological and negative emotional reactivity. It therefore seems possible that these images have a role in psychological adjustment to chronic pain for some sufferers and may contribute to long-term distress and disability. These findings suggest that a greater understanding of pain-related mental imagery may contribute to the psychological assessment and treatment of chronic pain sufferers.

APA, Harvard, Vancouver, ISO, and other styles

50

Schweinhardt, Petra. "Neural correlates of clinical pain processing in neuropathic and inflammatory pain patients and comparison with experimental pain." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:12e71d31-24f8-47e8-ba83-129575007644.

Full text

Abstract:

The goal of this thesis was to examine the processing of clinical pain in two patient groups with well defined primary pathologies, i.e. neuropathic pain patients and patients with rheumatoid arthritis (RA). It was hypothesized that chronic pain is associated with plastic changes in pain processing brain structures that can be detected using functional magnetic resonance imaging (FMRI). The first study, presented in Chapter 3, demonstrates that the neural representation of experimental heat pain is different in neuropathic pain patients than in age- and gender-matched healthy control subjects, although the pain stimulus was applied outside clinically affected areas. Increased activation was found in amygdala and anterior insula in the patient group and was accompanied by increased state anxiety and depression scores. Anterior insula is the focus of Chapter 4 in which it is demonstrated that clinical pain processing is located significantly more anteriorly in the insula than experimental pain processing, in close proximity to neural correlates of highly negative emotions and the conscious perception of bodily sensations. This offers a potential explanation for the shift of clinical pain processing. In Chapter 5, clinical pain is contrasted with experimental pain in the same patient population, i.e. patients with RA. In addition to comparing clinical and experimental pain processing, it was investigated if emotional and cognitive determinates of the pain experience, specifically depression and catastrophizing, exert different influences on the two types of pain. It is shown that clinical pain, but not experimental pain, is likely to be driven partially by depressive symptoms whereas catastrophizing is associated with the same neural activation pattern in both conditions. The cerebral representation of allodynic pain in neuropathic pain patients is presented Chapter 6. Chapters 6 and 7 demonstrate that the FMRI signal encodes the perceived intensity of clinical allodynic pain across subjects and that it reflects longitudinal variations of the perceived intensity within subjects. This thesis illustrates that FMRI can reveal subtle differences in the processing of clinical and experimental pain, despite brain activation patterns being similar on the whole. It also indicates that FMRI can be used to elucidate the origin of these differences, for instance by studying the influence of emotional and cognitive variables. This suggests that neuroimaging methods, in particular FMRI, have the potential to dissect clinical pain into its constituent parts, including central sensitization, brainstem facilitation and amplification by psychological factors. Such knowledge could potentially be exploited to target treatment selectively at different components of clinical pain and to monitor longitudinal changes of these components separately.

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'PanIN'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles