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Journal articles on the topic 'Pankaj Gupta'

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Published: 5 June 2025

Last updated: 15 July 2025

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Gupta, Pankaj. "Safe and Reliable Software." ITNOW 66, no. 2 (2024): 62–63. http://dx.doi.org/10.1093/itnow/bwae066.

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Kaul, Dinesh. "Malaria: BD Gupta, RK Maheswari, Pankaj Agarwal (eds)." Indian Journal of Pediatrics 87, no. 3 (2020): 247–48. http://dx.doi.org/10.1007/s12098-019-03157-2.

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Gupta, Pankaj. "Zero Trust and Data Engineering." ITNOW 66, no. 1 (2024): 62. http://dx.doi.org/10.1093/itnow/bwae030.

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Abstract Pankaj Gupta, a data analytics engineer from Discover Financial Services, puts zero trust under the microscope and explores why it's necessary, how it works and what the concept might mean for the future of security.

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Lichtenstein, Brad. "Gupta, Pankaj H. 2009. Apna Aloo Bazaar Becha: From subsistence ecology to the market (Film review)." International Journal of the Commons 4, no. 2 (2010): 782. http://dx.doi.org/10.18352/ijc.231.

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Lal, Prateek Kumar. "PROPER MANAGEMENT REQUIRED TO UPLIFT THE ECONOMY AND BUSINESS HOUSES AFTER THE PANDEMIC." INTERNATIONAL JOURNAL OF ADVANCED RESEARCH IN COMMERCE, MANAGEMENT & SOCIAL SCIENCE 08, no. 01(I) (2025): 111–14. https://doi.org/10.62823/ijarcmss/8.1(i).7177.

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The lives of people have been shattered after the corona uprise. With very cases detected initially in the capital the lives of people got affected and the second thing that was affected badly is the economy. Be it International or National, trades were decreasing and suddenly after the increase in COVID cases, it led to the implementation of lockdown announced by the PM of India. Life came to a sudden halt as the people got stuck in their homes and the Market that is shops, offices, malls, etc were all closed. Business houses incurred huge losses and suffered a lot during this pandemic. Stocks became obsolete, people became jobless and transportation was closed. The whole cycle needed to run the supply chain was hindered because of the closure, but the business houses did have to pay their fixed incomes such as salaries of employees, rent, maintenance, etc. which in whole was not easy and need to overcome as soon as possible. After the reduction in the number of cases and the development of the corona vaccine the market is slowly reviving and proper management is necessary to uplift the economy and help the business houses to recover and come on track. Case: During the Pandemic, there was a serious shortage of various equipment like Masks, Sanitizers, Ventilators, etc. some came up with very innovative, prompt, and cost-effective ideas among them were Mr. Gupta. Mr. Pankaj Gupta is the Managing Partner of Singapore-based “EthAum Venture Partners” (Chengappa, 2020). Ventilators that are much more capable of pumping 2000ml oxygen per minute support a bodyweight of max 280 kgs no one have that much weight. He came up with the lifesaving idea of splitting the oxygen supply to four people. Utilizing the underutilized ventilator saved millions of lives during the Pandemic.

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Dialameh, Babak, and Hamed Ebrahimian. "Discussion of “Transient Water Flow and Nitrate Movement Simulation in Partially Saturated Zone” by Jahangeer, Pankaj Kumar Gupta, and Brijesh Kumar Yadav." Journal of Irrigation and Drainage Engineering 145, no. 4 (2019): 07019003. http://dx.doi.org/10.1061/(asce)ir.1943-4774.0001384.

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Soltani, Amin, and Mehdi Mirzababaei. "Discussion of “Compaction and Strength Behavior of Tire Crumbles–Fly Ash Mixed with Clay” by Akash Priyadarshee, Arvind Kumar, Deepak Gupta, and Pankaj Pushkarna." Journal of Materials in Civil Engineering 31, no. 6 (2019): 07019004. http://dx.doi.org/10.1061/(asce)mt.1943-5533.0002701.

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Kumar, Amit, Samir Agarwal, Pankaj Khanna, Shobit Gupta, Rama Chandran, and Ananth S. Bommakanti. "Abstract 1903: Actionable mutational landscape in solid tumors: a case study of ovarian and colon cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 1903. https://doi.org/10.1158/1538-7445.am2025-1903.

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Abstract Background: Solid tumors are abnormal tissue masses that can be benign or malignant. They are named after the type of cells that form them, and can be categorized by where they originate such as breast, colon, bladder, ovary, and lung. Methods: Genomic profiling was done with sequencing of FFPE tumor samples 40 using Genes2Me PanCancer assay with 681 genes and the target size of 1.7 Mb on Illumina platform. Bioinformatics analysis was performed using standard GATK.v4.1.2 somatic variant calling pipeline. Mutational plots were generated using MAFtools and inhouse python script for post data analysis. Results: The number of mutant allele frequency (MAF) of the most frequently mutated genes varied significantly across tumor types, with the highest MAF observed in this cancer type. Significantly mutated cancer-related genes in solid tumors found the most frequently altered genes to be TP53(45%), KRAS(18%), TERT(14%), CDKN2A(12%), PIK3CA(11%), APC(36%), EGFR(10%), ESR1(20%), KIT(9%), AR(64%), MYC(44%), FGFR1(21%), BRCA1(22%), BRCA2(63%), CCND1(46%) in colon and ovarian carcinoma. Tumormutational burden (TMB) varied significantly across tumor types, and patients with high MAF had a significantly higher TMB score with one of the investigated platforms. Conclusion: These findings describe the similarities and differences between mutational signature of different solid tumors from cancer patients, providing valuable information for personalized medicine and also an important implication for the selection of patients for clinical trials with molecularly targeted therapies. Citation Format: Amit Kumar, Samir Agarwal, Pankaj Khanna, Shobit Gupta, Rama Chandran, Ananth S. Bommakanti. Actionable mutational landscape in solid tumors: a case study of ovarian and colon cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1903.

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Prachi, Singh, Kumar Maurya Sanjeev, and Nigam Gaurav. "AN ETHNOMEDICINAL STUDY OF PLANTS USED FOR THE TREATMENT OF VARIOUS SKIN PROBLEMS IN THE SIDHI DISTRICT OF MADHYA PRADESH, INDIA." Biolife 2, no. 3 (2022): 880–84. https://doi.org/10.5281/zenodo.7220557.

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ABSTRACT An Ethnobotanical study was made on the medicinal plants frequently  used  for  the  administration  of  skin problems in  Sidhi  district of  Uttar  Pradesh  by traditional  healers. The study revealed 30 species of plants belonging to 27 genera of 26 families. Leaves are the most frequently used plant part of ethnomedicinal species. It was also found that the ethnomedicinal plant species are over exploited in the study area. So there is urgent need to document ethnobotanical information before they get extinct and continuous efforts should be made to collect the information which will provide opportunity for future generation. Key words: Ethnobotanical, Skin problems, Sidhi, Traditional healers. REFERENCES Amestrong, D. & Cohen, J. 1999. Infectious diseases Mosby, Spain. 1(2): 35.1-35.70. Dam, P.K., Yadav, P., Ramnath,T. & Tyagi, B.K. 1998. Constraints in conservation of medicinal plants in the climatologically changing Thar desert. National Environment Science Academy, VIII Annual Congress Gulberga. Dwivedi, S.N. & Pandey, A., 1992. Ethnobotanical studies on wild and indigenous species of Vindhya plateau. Herbaceous Flora. J. Econ Tax Bot Addl. 1(10): 143-150. Dwivedi, S.N., Dwivedi, S. & Patel, P.C. 2006. Medicinal plants used by the tribal and rural people of Satna district, Madhya Pradesh for the treatment of gastrointestinal diseases and disorders. Natural Product Radiance. 5(1): 60-63. Jain, S.K. & Goel, A.K. 1995. A manual of ethnobotany. Scientific publishers, Jodhpur, India. 142-153. Maurya S.K., Nigam G. and Kumar V. 2012. Ethnomedicinal Study of Some Medicinal Plants Used by Rural Communities of district Jhansi, Uttar Pradesh. Online International Journal of Biosolution. 2 (4), 2012. 106-109. Oomanchanl, M., & Shrivastava, J.L. 1996. Flora of Jabalpur. Scientific Publishers, Jodhpur. Pankaj K. Sahu and Sharmistha Gupta.  2014. Medicinal plants of morning glory: convolvulaceae juss. Of central india (Madhya Pradesh and Chhattishgarh)  Biolife. 2(2), 463-469. Varghese, E. 1996. Applied Ethnobotany, A case study among the Khairas of Central India. Deep Publication, New Delhi.

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Dr., Pankaj Gupta, and Deepshikha Parashar Dr. "THE UNFINISHED AGENDA OF NATIONAL INTEGRATION." Raj-Yashti IX, no. 2, July-December, 2016 (2016): 91–101. https://doi.org/10.5281/zenodo.6327524.

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National Integration is the feeling of oneness among the citizens of the country and rising above all the parochial loyalties. India is a perfect example of unity in diversity. It is inhabited by many races, castes, religions , languages. It implies a sense of belonging, a feeling of togetherness and unity. The most serious problem faced by India at present is, how to create and maintain the sense of integrity among the people. National integration is under threat due to many factors like caste, regionalism, communalism, linguism, and politics of secession. This paper makes an attempt to understand the term national integration and takes into consideration about various disintegrative forces and try to give insight on the probable solutions to the problem.

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Traboulsi, Wael, Subhadip Kundu, Pankaj Gaur, et al. "Abstract LB339: PARP inhibition reprograms CD8 T cells, enhancing their function and generation of prolonged memory, leading to greater anti-tumor immune response." Cancer Research 83, no. 8_Supplement (2023): LB339. http://dx.doi.org/10.1158/1538-7445.am2023-lb339.

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Abstract Olaparib is the most widely studied third-generation PARP inhibitor (PARPi) in clinical practice with a significant clinical outcome in BRCA deficient tumors such as breast and ovarian cancers. However, innate and adaptive resistance in patients with DNA damage repair (DDR) gene mutations were reported after treatment with PARPi, highlighting the potential implication of other compartments such as the role of immune cells in the mechanism of resistance. Importantly, PARPi is shown to have an immune-modulatory capacity within the tumor microenvironment (TME) by activating the STING pathway and increasing interferon gamma (INF-gamma) and chemokine secretion and hence increasing the recruitment and function of CD8 T cells. In addition, PARPi is shown to affect other cells within the TME such as, macrophages, myeloid-derived suppressor cells (MDSCs) and cancer associated fibroblasts (CAFs), promoting either an immune enhancement or immune suppressor milieu that could indirectly affect CD8 T cell function. However, little is known about the direct effect of PARPi on CD8 T cells. In this study using two cold tumor models, we show that PARPi controls the tumor growth and increases survival in tumor-bearing mice. This effect is due to the enhancement of number and cytotoxicity of antigen-specific CD8 T cells and the maintenance of memory population within the TME. In vitro study shows that PARPi activates the SIRT-1/FOXO1 pathway, leading to the modification of gene expression related to memory and fatty acid oxidation (FAO) metabolism in CD8 T cells. As a result, a unique subpopulation of superior central memory cells with high recall responses and anti-tumor effects are generated after PARPi treatment. Interestingly this unique subpopulation was also generated after PARPi in human cells. Together, our findings highlight the direct effect of PARP inhibition on CD8 T cells and its ability to modulate and reprogram CD8 T cells within the TME, leading to a greater anti-tumor immune response. Citation Format: Wael Traboulsi, Subhadip Kundu, Pankaj Gaur, Zainab Ramlaoui, Dareen Sarhan, Nour Shobaki, Jacob Lee, Nazli Jafarzadeh, Simon T. Barry, Viia E. Valge-Archer, Vivek Verma, Seema Gupta, Samir N. Khleif. PARP inhibition reprograms CD8 T cells, enhancing their function and generation of prolonged memory, leading to greater anti-tumor immune response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB339.

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Gupta, Shobit, Amit Kumar, Pankaj Khanna, Rama Chandran, and Samir Agarwal. "Abstract 1906: Comprehensive genomic profiling for solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 1906. https://doi.org/10.1158/1538-7445.am2025-1906.

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Abstract Background: Next-generation sequencing technologies provides deep knowledge into the foundation of tumors and can advance the field of precision oncology. It can be used to effectively select the treatment based on druggable genomic alterations. In the present study, we prospectively investigated the clinical utility of a CGP assay in patients with metastatic tumors of the lung, breast, gynecologic, and colon etc. Methods: Genomic profiling was done on FFPE tumor samples using Genes2Me PanCancer assay. This assay, specifically adapted for the present molecular screening, is validated for clinical use and accredited by CEIVD and based on the guidelines published by the Association for Molecular Pathology, College of American Pathologists. It is a NGS-based product especially designed to identify genomic alterations, based on Food and Drug Administration, National Comprehensive Cancer Network guideline references, European Medicine Agency approvals, European Society for Medical Oncology (ESMO), updated every 3-6 months. It Targets around 681 genes with the size of 1.7 Mb containing different biomarkers such as DNA/RNA fusions, TMB, MSI and HPV related genes. It also incudes homologous recombinational repair (HRR) related genes. This panel was also designed to identify large scale rearrangements and special biomarkers such as MET exon 14skipping. Sequencing was done on Illumina platform. Bioinformatics analysis was performed using standard GATK.v4.1.2 somatic variant calling pipeline. Results: Most of the samples were sequenced with average depth of &gt;1000X. On target ration ranged between 82-94% with coverage % at 10X and 30X was more than 99%. In all the samples mutations were identifies with VAF ranges from 8-28%. mutations More than 50% samples have identified mutations with actionable FDA approved drugs. Conclusion: Although further studies are needed to support, this CGP assay is a noninvasive assay to guide therapeutic choice in oncology. It provides tumor heterogeneity profile that could be incorporated in routinely clinical practice. These findings may support the modification of the primary treatment in patients with metastatic solid tumors thus be the first step for future advances in precision oncology. Citation Format: Shobit Gupta, Amit Kumar, Pankaj Khanna, Rama Chandran, Samir Agarwal. Comprehensive genomic profiling for solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1906.

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Gaur, Pankaj, Vivek Verma, Mays Alreem Elayyan, et al. "Abstract 4217: MEKi in combination with anti-OX40 generates metabolically fit effector CD8+ T cells, enhances stem cell-like memory CD8+ T cells, and leads to strong anti-tumor activity." Cancer Research 82, no. 12_Supplement (2022): 4217. http://dx.doi.org/10.1158/1538-7445.am2022-4217.

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Abstract In the tumor microenvironment (TME), T cell exhaustion and short persistence of effector cells are crucial factors that limit the efficacy of endogenously generated or adoptively transferred effector cells. Regenerative stem-cell memory CD62LhiCD44lowSca1+ CD8+ CD8+ T cells (TSCM) persist longer and produce cells with more vital effector functions. OX40, a member of TNFRSF4, has been shown to promote the expansion and proliferation of activated effector T cells, leading to the generation of robust anti-tumor responses and immune memory. However, treatment with anti-OX40 as a single therapeutic modality has not generated desirable clinical outcomes. A combination of immune modulators has been found to enhance the therapeutic efficacy synergistically. Recently, we reported that inhibition of MEK1/2 using selumetinib (AZD6244) leads to a significant increase in the numbers of CD8+ TSCM cells with self-renewability, enhanced multipotency and proliferative capacity, leading to potent anti-tumor effects. Therefore, here we combined selumetinib with anti-OX40 to investigate if enhanced immune-mediated anti-tumor responses could be obtained. Using three mouse tumor models (TC1, B16, and CT26), we found that combination of MEKi with anti-OX40 enhances the anti-tumor activity by increasing the expansion of total and antigen-specific CD8+ T cells in the TME. These CD8+ T cells have higher functional activity as seen by increased Granzyme B and INF-γ production. We also found similar results after adoptive cell therapy (ACT) where infusion of MEKi-treated cells in B16 tumor-bearing mice synergized with anti-OX40 agonist treatment. Interestingly, anti-OX40 treatment of MEKi-treated CD8+ T cells enhanced the metabolic fitness as demonstrated by low mitochondrial potential and enhanced Oxygen Consumption Rates (OCR), Spare Respiratory Capacity (SRC), and Extra-cellular Acidification Rates (ECAR) compared to anti-OX40 treatment alone. Furthermore, OX40 agonist significantly enhanced the longevity of MEKi-induced CD8+ TSCM cells. In summary, our data provide a novel strategy to utilize MEKi to enhance the efficacy of ACT and combination immunotherapy using anti-OX40 agonist. Citation Format: Pankaj Gaur, Vivek Verma, Mays Alreem Elayyan, Zainab Ramlaoui, Simon T. Barry, Viia E. Valge-Archer, Paul D. Smith, Seema Gupta, Samir N. Khleif. MEKi in combination with anti-OX40 generates metabolically fit effector CD8+ T cells, enhances stem cell-like memory CD8+ T cells, and leads to strong anti-tumor activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4217.

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Shobaki, Nour, Pankaj Gaur, Rahul Nadre, et al. "Abstract LB566: Class 1 HDAC inhibition induces antitumor immunity by NF-kB-mediated enhanced metabolic fitness and generation of unique effector function enriched memory CD8 T cell subtype." Cancer Research 82, no. 12_Supplement (2022): LB566. http://dx.doi.org/10.1158/1538-7445.am2022-lb566.

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Abstract Histone/protein deacetylases (HDACs) are a class of enzymes that regulate gene expression and are involved in regulating the transcription process as well as regulating fundamental cellular processes such as proliferation, differentiation and development. Class I HDACs (which includes HDAC1, 2, 3, and 8) contribute in epigenetic regulations of T cell tolerance. Under anergic T cell condition, HDAC1 and HDAC2 are involved in the histone deacetylation. However, the role of HDACs in CD8 T cell function and differentiation is not well understood. Therefore, we aimed to understand the effect of HDAC inhibition (HDACi) on CD8 T cells phenotype and functionality by using Entinostat (ENT), a class I HDAC (HDAC1 and 3) inhibitor. We found that ENT induces strong immune-mediated anti-tumor effects in TC-1 and B16 tumor-bearing mice. Mechanistically, ENT modulated the tumor microenvironment through an increased infiltration of CD8 T cells, enhanced CD8 T cell antigen-specificity and CD8 T cell functionality represented by interferon gamma (IFN-γ) and granzyme B (GrB) secretion. Our in vitro and in vivo data also indicate that ENT enhances central memory phenotype (CD62L+, CD44+) of CD8 T cells. We also found that ENT-treated CD8 T cells have distinct metabolic phenotype compared to activated CD8 T cells. Specifically, these cells relied more on amino acid metabolism while, unexpectedly, they had lower fatty acid uptake with enhanced mitochondrial potential (TMRM). Interestingly, ENT-induced central memory CD8 T cells also showed increased mitochondrial potential as well as reliance on amino acid metabolism. Therefore, ENT treatment induced memory cells with a unique phenotype different from the classical memory CD8 T cells with enhanced effector functions and reliance on distinct metabolic pathways. Furthermore, ENT-treated CD8 T cells have higher peaks at H3K27Ac site compared to the control. Since these peaks are mostly associated with genes such as IFN-γ, GrB, Pim1, EOMES, and IL-2, the known canonical target genes of NF-κB in CD8 T cells, we further dissected the role of NF-κB in these ENT-mediated effects. First, motif analysis showed that NF-κB binding motif is enriched in differential H3K27Ac sites associated with HDACi. Next, flow cytometry and immunofluorescence analysis showed that although ENT does not increase total NF-κB levels in CD8 T cells, it enhances its binding to the chromatin due to enhanced gene accessibility. This research highlights the significance of epigenetic modulation in enhancing the immune-mediated anti-tumor effects and provide fundamental understanding of the mechanism of action of HDAC inhibition in CD8 T cells. Citation Format: Nour Shobaki, Pankaj Gaur, Rahul Nadre, Vivek Verma, Peter Ordentlich, Lei Wang, Nazli Jafarzadeh, Wael Traboulsi, Mikayel Mkrtichyan, Seema Gupta, Samir N. Khleif. Class 1 HDAC inhibition induces antitumor immunity by NF-kB-mediated enhanced metabolic fitness and generation of unique effector function enriched memory CD8 T cell subtype [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB566.

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Jafarzadeh, Nazli, Pankaj Gaur, Dareen Sarhan, et al. "Abstract LB217: Ascorbic acid rescues antitumor immune response by reversing hypoxia-induced CD8+T cell dysfunction." Cancer Research 82, no. 12_Supplement (2022): LB217. http://dx.doi.org/10.1158/1538-7445.am2022-lb217.

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Abstract Growing evidence suggests that hypoxia is one of the most important phenomena of solid tumors that supports tumor progression as well as therapeutic resistance. When T cells infiltrate the tumor microenvironment (TME), they encounter hypoxia and, in this condition, cells upregulate an evolutionary conserved Hypoxia-inducible factor 1 (HIF-1) transcription factor to adapt to the hypoxic stress. Hypoxia has been reported to alter specific aspects of CD8+ T cell biology through various mechanisms but in large part by the HIF1-α, leading to immune suppression. Therefore, identification and development of drugs that target hypoxia is critical to augment immune cells' function and enhance the anti-tumor response of immunotherapy. Over the past decades, several cellular and pre-clinical studies have shown that ascorbic acid (AA) possesses anti-tumor properties and acts as an adjuvant to various cancer therapies. AA, as a proven redox potential modulator, has proved to also be effective in targeting oxygen sensing regulator (reducing Hif1-α levels) and epigenetic reprogramming (increasing ten-eleven translocation (TET) methylcytosine dioxygenase enzymatic activity) in cancer cells. Most recently, immunomodulating potential of AA has been recognized as it enhanced the efficacy of checkpoint blockade by increasing immune cell infiltration within the TME. However, the exact mechanisms by which AA exerts immunotherapeutic effects in cancer have not been fully understood. Here, we hypothesized that AA exerts its immunotherapeutic effects by targeting tumor-induced hypoxic stress in CD8 T cells. Indeed, we found that AA induces a robust anti-tumor response by decreasing tumor volume and increasing mice survival. Immune profiling in the TME revealed that AA increases the infiltration of CD8+ T cells with enhanced cytotoxic cytokine production and proliferation. To further evaluate the underlying mechanism, we challenged CD8+ T cells with a cognate antigen ex vivo under the hypoxic/normoxic conditions. We found that hypoxia negatively affected the effector functions and proliferation of CD8 T cells. Interestingly, AA could reverse these effects, bringing the function and proliferation of cells back to the normoxic level by increasing the expression of Granzyme B, Interferon gamma and Ki-67. This reversal of hypoxia-induced adverse effects on CD8 T cells was achieved by AA-mediated decrease in the Hif1-α levels (a hypoxia mediator) and increase in TET-2 protein expression and function (characterized by increased 5-hydroxymethylcytosine (5-hmc) levels). Moreover, AA treatment could significantly enhance the metabolic fitness of CD8+ T cells (characterized by improved glycolytic ability and mitochondrial function) that were exposed to severe hypoxia. In conclusion, our data indicate that AA treatment shows enhanced anti-tumor effects via restoring cytotoxic T cell functions under hypoxic TME. These results also provide new insights into the immunomodulatory effects of AA via targeting hypoxia in CD8 T cells. Given that hypoxia in the TME is a barrier for generation of effective immune response, our results suggest that AA treatment is an effective strategy against cancer and may further enhance the anti-tumor effects of immunotherapeutic agents. Citation Format: Nazli Jafarzadeh, Pankaj Gaur, Dareen Sarhan, Nour Shobaki, Wael Traboulsi, Zainab Ramlaoui, Vivek Verma, Seema Gupta, Samir N. Khleif. Ascorbic acid rescues antitumor immune response by reversing hypoxia-induced CD8+T cell dysfunction [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB217.

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Sinha, Surajit, Abir Panda, Zeribe Nwosu, et al. "Abstract C106: IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis." Cancer Research 84, no. 2_Supplement (2024): C106. http://dx.doi.org/10.1158/1538-7445.panca2023-c106.

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Abstract Introduction: Metastatic outgrowth and colonization requires that disseminated tumor cells simultaneously compensate for alterations in nutrient availability, counteract oxidative stress, and evade host innate and adaptive immune surveillance. The mechanistic underpinnings of how these vital processes are coordinated is not understood. Experimental procedures: Using intrasplenic injection (liver metastases) and tail vein injection (lung metastases), we employed a gain-of-function cDNA screen in mice to identify regulators of colonization. In doing so, we identified GCN1 signaling as indispensable to the disseminated pancreatic cancer cell. Summary of unpublished data: Specifically, we demonstrate that alterations in nutrient availability encountered in target organs (liver, lung) trigger pancreatic cancer cells to utilize GCN1 stress signaling to upregulate the expression of serine, folate, and methionine pathway biosynthetic enzymes together with amino acid transporters through the integrated stress response effector ATF4. These pathways act in concert to facilitate acquisition of metabolites critical for cellular functions including maintenance of redox homeostasis. Surprisingly, we found that GCN1 also functions in the nucleus, where it interacts with HNRNPK to destabilize the transcripts encoding natural killer (NK) cell activation ligands and key regulators of major histocompatibility complex (MHC) class I molecules. Intriguingly, we identified an endogenous protein rheostat, IMPACT, for GCN1’s dual functions and show that IMPACT expression is lost in human pancreatic metastases through DNA methylation. IMPACT overexpression in pancreatic cancer cell lines inhibited the integrated stress response effector ATF4 to retard nutrient uptake and activated the expression of NK cell ligands and MHC class I molecules to fuel anti-tumor immune responses. Conversely, IMPACT knockout enabled successful acquisition of metabolic intermediaries in response to nutrient alterations and suppressed anti-tumor immune response to accelerate metastatic outgrowth. Accordingly, bioinformatic analyses of human pancreatic cancer showed that while the expression of GCN1 increases in metastatic disease, the expression of IMPACT is lost, correlating with significantly shorter survival of GCN1-high, IMPACT-low expressing tumors. Finally, IMPACT overexpression synergized with immune checkpoint inhibitors in mice to eliminate macrometastases formation. Conclusion: In summary, we have identified IMPACT as an immunometabolic checkpoint that restrains GCN1-mediated metabolic plasticity and GCN1-mediated suppression of innate and adaptive immune surveillance. We propose that drugs that can restore IMPACT expression or IMPACT mimetic agents will have therapeutic value for patients with pancreatic cancer. Citation Format: Surajit Sinha, Abir Panda, Zeribe Nwosu, Rodrigo Neves Das, Xu Ke, Elke van Beek, Alexander J. Rossi, Reed I. Ayabe, James McDonald, Michael M. Wach, Samantha Ruff, Priyanka P. Desai, David Sun, Martha E. Teke, Emily A. Verbus, Areeba Saif, Shreya Gupta, Tahsin Khan, Leila Sarvestani, Carrie E. Ryan, Jacob Lambdin, Kirsten Remmert, Emily Smith, Kenneth Luberice, Stephie Lux, Imani A. Alexander, Tracey Pu, Allen Luna, Sarfraz R. Akmal, Shahyan Rehman, Ashley Rainey, Hanna Hong, Yuri Lin, Samantha Sevilla, Gasmi Billel, Sivasish Sindiri, Todd Prickett, King Chan, Eileen Li, Xiaolin Wu, Nicholas D. Klemen, Giorgio Trinchieri, Costas A. Lyssiotis, Jeremy Davis, Pankaj K. Singh, Steven A. Rosenberg, Michael B. Yaffe, Filippo Giancotti, Ethan M. Shevach, Jonathan M. Hernandez. IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Pancreatic Cancer; 2023 Sep 27-30; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(2 Suppl):Abstract nr C106.

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Odelu, G. "PRESENT STATUS OF AQUATIC MACROPHYTES OF FOUR FRESH WATER ECOSYSTEMS OF ELLANDHAKUTA AND ITS SURROUDING VILLAGES, KARIM NAGAR DISTRICT, TELANGANA. INDIA." Biolife 2, no. 3 (2022): 956–65. https://doi.org/10.5281/zenodo.7224935.

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ABSTRACT Present study was conducted on four fresh water ecosystems to analyses,the importance of fresh ecosystems biological components, species diversity, alienspecies, aquatic macrophytes distribution in four  villages around study area was studied during 2012-2014. One hundred and ten different species of were recorded in 41 families in these 24 from Dicotyledons, 14, Monocots, two from Pteridophyta, one from Algae total Genera 84. Poaceae was the most dominant families with 14 species followed by Cyperaceae (10species), Asteraceae(9), Euphorbhiaceae (7), and Twenty five families were represented by one species each. But unfortunately, such very resourceful fresh water ecosystems are gradually degrading due to various natural and manmade activities like, development of commercial fisheries, excessive growth of invasive aquatic weeds mainly Eichhornia crassipes (Mart.) S.L., Leersia hexandra SW and Hymenachne acutigluma (Steud) Gill which are suppressing the growth of other associated species,causing of loss of native biota. The migratory birds are Actitis hypoleucos, Ardea purpurea, Plegadis chihi, Mycteria leucocephala. Key Words: Macrophytes, Invasive weeds, Native biota, Emergent anchored weeds REFERENCES Ambasht, R. S. (2005). Macrophytes limnology in the Indian subcontinent. Ukaaz Publication, Hyderabad: 58 – 174. Bhaskar, V. & Raji, B.A. 1973. Hydrophytes and marsh plants of Mysore city. Prasaranga, University of Mysore, Mysore, India. Bhattacharjee DK, Sarma SK, Devi B, Journal. Eco. Taxo.Bot, 2006, 30 (suppl), 133-139. Bhattacharjee DK, Sarma SK, Bora PC, Kar A, Journal of Advance Plant Sciences, 2008, 4(1&2), 69-73. Billore DK, Vyas IN, International Journal of Ecological Science, 1981, (7), 45-54. Biswas K, Calder CC, Hand book of common water and marsh plants of India and Burma. Calcutta. 1936. ( revised ed.1954). Borah B, Sarma SK, Journal of Advance plant Sciences, 2012, 6 (5 & 6), 91-101. Cowardian LM, Carter V, Golet FC, LaRoe ET, Classification of Wetlands and Deepwater Habitats of the United States. FWS/OBS-79/31. U.S. Fish and Wildlife Service: Washington, D.C.,1979. Cook, C.D.K. (1996). Aquatic and wetland plants in India Oxford University press. London. Carpenter, S. R., Lodge, D. M. (1986) Effects of submersed macrophytes on ecosystem processes. Aquatic Bot 26: 341-370. Chambers, P.A., P. Lacoul, K.J., Murphy, S.M., (2010). World checklist of macrophyte species. Published on the internet; http://fada.biodiversity.be/group/show/60 accessed 10 August. Daubenmire RF, Plants and Environment. New York, 1947. Deka U, Sarma SK, New York Science Journal, 2014, 7 (6), 1-8. Ghosh SK, Illustrated Aquatic and Wetland Plants in Harmony with Mankind, Standard Literature, Kolkota. 2005. Dutta R, Baruah B, Sarma SK, Annal of Biological Research, 2011, 2(4), 268-280. Dutta R, Barua D, Sarma SK, Hazarika LP, Nature Environment and Pollution Technology, 2010, 9(2), 283. Bentham, G. & Hooker, J.D. 1862 - 1883. Genera Plantarum. 3-vols. L. Reeve & Co Ltd, Ashford, Kent. London. Gopal B, Wetland and biodiversity: How to Kill Two Birds With One Stone ? In: W.Giesen (Ed.). Wetlands Biodiversity and Development. Proceeding of Workshop of the International Conference on Wetlands and Development held in Kuala Lumpur, Malaysia, and 9-13 October 1995. Wetlands Internationals, Kuala Lumpur,1997,pp18-28. Kachroo, P. 1984. Aquatic Biology in India. Bishen Singh Mahendra Pal Singh, Dehra Dun Kayode, J. and Ogunleye, O.T. (2008) Checklist and Status of Plant Species Used as Spices in Kaduna State of Nigeria. African Journal of General Agriculture 4, 13-18. Kiran, B.R., Patel A.N., Kumar Vijaya and Puttaiah E.T. (2006). Aquatic macrophytes in fish culture ponds at Bhadra fish farm, Karnataka. J. Aqua.Biol. 21(2): 27– 30. Krull, J.N. (1970). Aquatic plant-invertebrate associations and waterfowl. Journal of Wildlife Management 34:707-718. Kumar, M. and Singh, J. (1987) Environmental impacts of Aquatic Weeds and their classification. Proceedings of the workshop on management of Aquatic Weeds, Amritsar, Punjab, India. [24]Majid,F.Z. (1986). Aquatic Weeds –Utility and Development, Agro Botanical Publishers, India. Naskar, K.R. (1990). Aquatic and Semi-aquatic Plants of the Lower Ganga Delta. Daya Publishing House, New Delhi. Pankaj K. Sahu and Sharmistha Gupta. Medicinal plants of morning glory: convolvulaceae juss. Of central India (Madhya Pradesh & Chhattishgarh). 2014. Biolife. 2(2):463-469. Raunkiaer, C. 1934. The life forms of plants and statistical plants geography. ClarendonPress,Oxford. Singh, A.K. 2006. A contribution to the Aquatic and Wetland flora of Varanasi. J. Econ.Taxon. Bot. 30(1): 6 – 24 Srivastava RC, Kumar A, Journal of Ecology Tau. Bor, 1987, 9, 433-458 Subramanyam K. Aquatic Angiosperms, New Delhi. 1962 Unni KS, Journal of Bombay Natural History Society, 1971, 64(1), 95-102.

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Vikas, Kumar. "BANARAS: A PARALLEL SPACE OF THE COSMIC UNIVERSE AND ITS CONTRIBUTION TO ARCHITECTURE." International Journal of Advanced Research 8, no. 10 (2020): 936–43. http://dx.doi.org/10.21474/ijar01/11920.

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From its prominent position on the river Ganges , Banaras has borne testimony to a flourishing civilization and the many socio-political turmoil associated with a thriving territory from the ancient kingdoms of Aryans with its mention in Ramayana to the combats of medieval rulers of Mauryan and Gupta dynasty and the never ceasing instability during the dominance of Muslim and British regime.[1] The historical unrest has vanished and the city with its inhabitants of “grin-and-bear-it” attitude endured every phase of this turmoil and adapted to it and commemorated every such change in their stories and culture. Every paradigm shift gave Banaras its own unique Art and Culture which it (Banaras) has assimilated and made it its very own signature be it Food, Fabric, Jewellery, Lifestyle, Mode of communication, Weapons, Architecture, Mythology, Tales, Culture, Cult , Art and much more The citys divine image , its elaborate traditional rituals , its prodigious display of the hand-in-hand existence of art and the mundane activities of life. All give it a peculiar feel, though the city has tried to keep pace with time, it has modernized or commercialised but what has stayed with time is what satiates the quench of a mystic or an explorer of Art and Culture . This write up here is an attempt to bring to words the connection between what the oldest civilizations or cults have left to enrich the Art & culture or other-way-round , how by exploring the existing we are able to get a glimpse into the glorious past that has passed and enriched India .This manuscript is a study and construal of Varanasi from the perspective of one who is close enough to the hindu tradition to see its religious significance and also close enough to art , design and academics to know the understanding that Arts and Varanasi might pose. The journey towards the finalization of this script started with mapping the city and searching for the temples mentioned in various texts and my work is based on two primary sources : the city itself with its multitude of temples , its seasons of pilgrimage , the Akharas , voluminous literature on Banaras and its pandas and lay interpreters.

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Nursiani, Lubis, Rauf Abdul, and Sabrina T. "Growth and production response of mung bean (Vigna radiata L) by application of mycorriza and Penicillium sp in paddy lands." Jurnal Pertanian Tropik 7, no. 1 (2020): 64–71. http://dx.doi.org/10.32734/jpt.v7i1.3710.

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ABSTRACT This study aimed to evaluate the effect of mycorrhiza and Penicilliumsp on the growth and production of mung beans in paddy land. The design of this experimental research was a factorial Randomized Block Design (RBD) with 2 factors and 3 replications. The first factor was the dosage of mycorrhiza consisting of 0 g/plant; 5 g/plant; 10 g/plant; and 15g/plant. The second factor was the type of phosphate solubilizing microbes consisting of withoutPenicilliumsp; Penicilliumspfrom Mursala island (20 ml/plant); Penicilliumsp collection taken from soil biology laboratory of faculty of agriculture USU (20 ml/plant). The results showed that the dosage of Mycorrhiza and Penicilliumsp were not significantly affected the height of mung bean plants, however, it significantly affected the population of Penicillium sp. The application of 15 g Mycorrhiza with Penicilliumsp from Mursala was the best treatment for the growth of mungbean plants at 4 weeks after planting (42.98 cm) and the interaction of Mycorrhiza15 g/plant and PenicilliumspMursala produced the best seeds/plant of 16.76 g/plant. REFERENCES Adiningsih, S. 2004. Nutrient dynamics in soil and nutrient uptake mechanisms. Soil Research Center. Ministry of Agriculture. Jakarta. Badan Pusat Statistik. 2016. Production of Cassava and Green Beans by Province in 1993-2015. Jakarta. Budiman, A. 2004. Application of Cashing and Arbuscular Mycorrhizal Fungi on Ultisols and the Effects on the Development of Soil Microorganisms and the Result of Semi Corn (Zea mays L.). Thesis of the Faculty of Agriculture. Andalas University. Padang. De datta, S.K. 1990. Principle and Practice of Rice Production. New York. Dobermann, A. and T. Fairhurst. 2000. Rice, Nutrient disorders and nutrient management. IRRI and Potash and PPI/PPIC. Manila, Philipina. Fitriatin, B. M., A. Yuniarti., O. Mulyani., F. S. Fauziah., dan M. D. Tiara. 2009. Effect of Microbial Solvents on Phosphate and Fertilizer P on Available P, Phosphatase Activity, P on Plants and Upland Rice Results on Ultisol. Agriculture Journal20 (3) : 210 – 215. Harahap, F.S. 2009. Pengujian pengolahan tanah konservasi dan inokulasi mikoriza terhadap sifat fisik dan kimia tanah serta produksi beberapa varietas kacang tanah (Arachis hypogaea. L) Universitas Sumatra Utara Medan. Skripsi. Hasanuddin and Bambang. G. M. 2004. Utilization of phosphate and mycorrhizal microbial solvents to repair available phosphorus, soil phosphorus uptake (ultisol) and maize yields (on ultisol). Journal of agricultural sciences Indonesia, 6 (1): 8 – 13. Husin, E.F. 2000. Fungus Arbuskula Mycorrhiza. Andalas University Faculty of Agriculture. Padang. Illmer, P. and F. Schinner. 1992. Solubilization of inorganic phosphate by microorganisms isolated from forest soils. Journal Soil Biology Biochem, 24 (4): 389 – 395. Sastrahidayat, R. 2011. Science of fungi (Mycology). Universitas Brawijaya Press. Malang. Sembiring and Fauzi. 2017. Bacterial and Fungi Phosphate Solubilization Effect to Increase Nutrient Uptake and Potatoes (Solanum tuberosum L.) Production on Andisol Sinabung Area. Journal of Agronomy 16 (3) : 131 – 137. Sitrianingsih. 2010. The Effect of Arbuscular Vesicular Mycorrhiza Inoculation on the Growth of Pandak Pule Seedlings (Rauvolfia verticillata Lour.) Publication Text. Biology Department Faculty of Mathematics and Natural Sciences Sebelas Maret University Surakarta. Suratmin, D. Wakano, D. Badwi. 2017. The use of compost and phosphorus fertilizer on the growth of green bean plants. Journal of Biology Science & Education, 6 (2): 148 – 158. Susanti, R., Afriani, A., Harahap, F.S., Fadhillah, W., Oesman, R. and Walida, H., 2019. Application Micoriza and Baean Varieties by Conservation Tillage for Biological Soil Properties Improvement. Jurnal Pertanian Tropik, 6 : 34-42. Syawal, F., Rauf, A. dan Rahmawaty. 2017. Upaya rehabilitasi tanah sawah terdegradasi dengan menggunakan kompos sampah kota di Desa Serdang Kecamatan Beringin Kabupaten Deli Serdang. Jurnal Pertanian Tropik 4 3 :183-189. Syawal, F., Rauf, A., Rahmawaty, R. dan Hidayat, B. 2017. Pengaruh Pemberian Kompos Sampah Kota Pada Tanah Terdegrdasi Terhadap Produktivitas Tanaman Padi Sawah Di Desa Serdang Kecamatan Beringin Kabupaten Deli Serdang. Dalam Prosiding SEMDI-UNAYA (Seminar Nasional Multi Disiplin Ilmu UNAYA) (Vol. 1, No. 1, pp. 41-51). Wakelin, S.A, V.V.S.R. Gupta, P.R Harvey, and M.H. Ryder. 2007. Commonwealth Scientific and Industrial Organisation (CSIRO) Land and Water, PMB 2, Glend Osmon, SA 5064, Australia. Whitelaw. 2000. Growth promotion of plants inoculated with phosphate solubilizing fungi. Journal Adv. Agron 69 : 99 – 151.

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K K A, Abdullah, Robert A B C, and Adeyemo A B. "August 2016 VOLUME 5, ISSUE 8, AUGUST 2016 5th Generation Wi-Fi Shatha Ghazal, Raina S Alkhlailah Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5801 ECG Arrhythmia Detection Using Choi-Williams Time-Frequency Distribution and Artificial Neural Network Sanjit K. Dash, G. Sasibhushana Rao Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5802 Data Security using RSA Algorithm in Cloud Computing Santosh Kumar Singh, Dr. P.K. Manjhi, Dr. R.K. 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Ghodke Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5809 Automatic Single and Multi Topic Summarization and Evolution to Generate Timeline Mrs. V. Meenakshi, Ms. S. Jeyanthi Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5810 Data Hiding in Encrypted HEVC/AVC Video Streams Saltanat Shaikh, Prof. Shahzia Sayyad Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5811 A Study of Imbalanced Classification Problem P. Rajeshwari, D. Maheshwari Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5812 Design of PTL based Area Efficient and Low Power 4-bit ALU Saraabu Narendra Achari, Mr. C. Pakkiraiah Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5813 The Design of Driver Safety Awareness and Assistance System through Sleep Activated and Auto Brake System for Vehicle Control D. Sivabalaselvamani, Dr. A. Tamilarasi, L. Rahunathan and A.S. Harishankher Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5814 Parameters Selection, Applications & Convergence Analysis of PSO Algorithms Sachin Kumar, Mr. N.K. Gupta Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5815 Effective Pattern Deploying Model for the Document Restructuring and Classification Niketa, Jharna Chopra Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5816 Cataloging Telugu Sentences by Hidden Morkov Techniques V. Suresh Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5817 Biometrics for Cell Phone Safety Jyoti Tiwari, Santosh Kumar Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5818 Digital Image Watermarking using Modified DWT&DCT Combination and Bi Linear Interpolation Yannam .Nagarjuna, K. 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Barbole Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5830 Design of Low Pass Digital FIR Filter Using Nature Inspired Technique Nisha Rani, Balraj Singh, Darshan Singh Sidhu Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5831 Issues and Challenges in Software Quality Assurance Himangi, Surender singh Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5832 Hybridization of GSA and AFSA to Detect Black Hole Attack in Wireless Sensor Network Soni Rani, Charanjit Singh Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5833 Reversible Watermarking Technique for Data Hiding, Accurate Tamper Detection in ROI and Exact Recovery of ROI Y. Usha Madhuri, K. 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Savkare Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5854 Comparison Study of Induction Motor Drives using Microcontroller and FPGA Sooraj M S, Sreerag K T V Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5855 A Survey on Text Categorization Senthil Kumar B, Bhavitha Varma E Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5856 Multirate Signal Reconstruction Using Two Channel Orthogonal Filter Bank Sijo Thomas, Darsana P Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5857 The Multi-keyword Synonym Search for Encrypted Cloud Data Using Clustering Method Monika Rani H G, Varshini Vidyadhar Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5858 A Review on Various Speech Enhancement Techniques Alugonda Rajani, Soundarya .S.V.S Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5859 A Survey on Various Spoofing Attacks and Image Fusion Techniques Pravallika .P, Dr. K. 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Kshirsagar Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5865 Compact Microstrip Octagonal Slot Antenna for Wireless Communication Applications Thasneem .H, Midhun Joy Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5866 ‘Aquarius’- Smart IOT Technology for Water Level Monitoring System Prof. A. M. Jagtap, Bhaldar Saniya Sikandar, Shinde Sharmila Shivaji, Khalate Vrushali Pramod, Nirmal Kalyani Sarangdhar Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5867 Future of Results in Select Search Engine Peerzada Mohammad Iqbal, Dr. Abdul Majid Baba, Aasim Bashir Abstract | PDF with Text | DOI: 10.17148/IJARCCE.2016.5868 Semantic Indexing Techniques on Information Retrieval of Web Content." IJARCCE 5, no. 8 (2016): 347–52. http://dx.doi.org/10.17148/ijarcce.2016.5869.

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R, Remesh Kumar, and Aparna C. Ajayan. "Behavioral Disorders in Children: BD Gupta, RK Maheshwari, Anil Kumar Arora, Pankaj Agrawal, Adarsh Purohit and Shivji Ram Choudhary (eds)." Indian Journal of Pediatrics, February 21, 2024. http://dx.doi.org/10.1007/s12098-024-05079-0.

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