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1

Haas, Sarah K., Virginia Hayssen, and Paul R. Krausman. "Panthera leo." Mammalian Species 762 (July 2005): 1–11. http://dx.doi.org/10.1644/1545-1410(2005)762[0001:pl]2.0.co;2.

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2

Diedrich , Cajus G. "Pleistocene Panthera leo spelaea (g." Quaternaire, no. 22/2 (June 1, 2011): 105–27. http://dx.doi.org/10.4000/quaternaire.5897.

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3

Christiansen, Per. "Distinguishing skulls of lions (Panthera leo) and tigers (Panthera tigris)." Mammalian Biology 73, no. 6 (November 2008): 451–56. http://dx.doi.org/10.1016/j.mambio.2007.08.001.

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4

Mozos, E., P. Ginel, A. Diz, B. Blanco, J. Negrini, R. Guerra, and M. Novales. "Otolithiasis in African Lions (Panthera leo)." Journal of Comparative Pathology 150, no. 1 (January 2014): 124. http://dx.doi.org/10.1016/j.jcpa.2013.11.199.

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5

Libert, Cédric, Christophe Ravel, Francine Pratlong, Patrick Lami, Jacques Dereure, and Nicolas Keck. "LEISHMANIA INFANTUMINFECTION IN TWO CAPTIVE BARBARY LIONS (PANTHERA LEO LEO)." Journal of Zoo and Wildlife Medicine 43, no. 3 (September 20, 2012): 685–88. http://dx.doi.org/10.1638/2012-0056.1.

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6

Metter, J. E. Van, M. Dana Harriger, and Rosina H. Bolen. "Environmental enrichment utilizing stimulus objects for African lions (Panthera leo leo) and Sumatran tigers (Panthera tigris sumatrae)." BIOS 79, no. 1 (March 2008): 7–16. http://dx.doi.org/10.1893/0005-3155(2008)79[7:eeusof]2.0.co;2.

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7

Lucena, Ricardo B., Rafael A. Fighera, and Claudio S. L. Barros. "Cistos peribiliares em leão-africano (Panthera leo)." Pesquisa Veterinária Brasileira 31, no. 2 (February 2011): 165–68. http://dx.doi.org/10.1590/s0100-736x2011000200012.

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São descritos os achados macroscópicos e histopatológicos de cistos peribiliares em uma fêmea adulta de leão-africano (Panthera leo). Macroscopicamente, todos os lobos hepáticos continham numerosos cistos preenchidos por líquido translúcido. Histologicamente, os cistos estavam localizados no hilo hepático e nos tratos portais. Os cistos eram revestidos internamente por epitélio simples, constituído por células colunares ou cuboidais e não mucinosas, de acordo com avaliação para ácido periódico de Schiff/azul alciano. Na imuno-histiquímica, todas as células desse epitélio foram positivas para citoceratina. O leão morreu de complicações relacionadas a um carcinoma pulmonar e não foram observadas alterações clínicas associadas à lesão hepática, comprovando que cistos peribiliares em leões também ocorrem não associados a sinais clínicos.
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8

Bizari, Thiago G., Betina F. Lautert, and Renato S. de Sousa. "Biliary cystadenoma in a lion (Panthera leo)." Brazilian Journal of Veterinary Pathology 15, no. 1 (March 31, 2022): 54–56. http://dx.doi.org/10.24070/bjvp.1983-0246.v15i1p54-56.

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Animals in human care often exceed the life expectancy of animals in the wild when they have veterinarian follow-ups, no competition for space or food, and continuous care. Advanced age favors the development of mutations that often trigger cancer, which sometimes causes death. There are reports in the literature on neoplasms in lions in the liver, which are one of the main organs affected. A 20-year-old lion specimen was received for necropsy at the Federal University of Paraná, Curitiba, Brazil. Multiple cystic dilations were observed in the liver. Histologically, they were internally covered by a simple cuboidal epithelium, similar to that observed in the bile ducts, without cellular atypia. The adjacent liver parenchyma presented with mild disorganization of the hepatocyte cords. Biliary cystadenomas are benign growths formed by a thin opaque capsule filled with a slightly yellowish translucent fluid compressing the adjacent liver parenchyma, as highlighted in this case. The epithelium of the cysts was positive for anti-cytokeratin (CK) (EIA/A3E) and anti-CK7, confirming histogenesis in the bile ducts. This study reports a case of biliary cystadenoma in a Panthera leo specimen.
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9

Tucker, Alison R., Edward C. Ramsay, and Robert L. Donnell. "Oligodendroglioma in an African Lion (Panthera leo)." Journal of Zoo and Wildlife Medicine 39, no. 4 (December 2008): 650–54. http://dx.doi.org/10.1638/2007-0097.1.

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10

Martella, Vito, Marco Campolo, Eleonora Lorusso, Paolo Cavicchio, Michele Camero, Anna L. Bellacicco, Nicola Decaro, et al. "Norovirus in Captive Lion Cub (Panthera leo)." Emerging Infectious Diseases 13, no. 7 (July 2007): 1071–73. http://dx.doi.org/10.3201/eid1307.070268.

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11

Harrison, T. M., C. A. McKnight, J. G. Sikarskie, B. E. Kitchell, M. M. Garner, J. T. Raymond, S. D. Fitzgerald, V. E. Valli, D. Agnew, and M. Kiupel. "Malignant Lymphoma in African Lions (Panthera Leo)." Veterinary Pathology 47, no. 5 (July 7, 2010): 952–57. http://dx.doi.org/10.1177/0300985810375054.

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12

Jayakumar, C. S., Swapna Susan Abraham, and D. Sanjay. "Congenital megacolon in a Lion (Panthera leo)." Zoos' Print Journal 20, no. 9 (August 21, 2005): 1998. http://dx.doi.org/10.11609/jott.zpj.1365.1998.

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13

Hayward, Matt W., and Graham I. H. Kerley. "Prey preferences of the lion ( Panthera leo )." Journal of Zoology 267, no. 03 (October 18, 2005): 309. http://dx.doi.org/10.1017/s0952836905007508.

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14

Gjurovski, I., T. Ristoski, S. Kostadinova Kunovska, J. Milosevski, and V. Levajkovic-Trajkov. "Facial Myxofibrosarcoma in a Lion (Panthera leo)." Journal of Comparative Pathology 174 (January 2020): 197. http://dx.doi.org/10.1016/j.jcpa.2019.10.184.

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15

Chandra, A. M. Sundeep, Rebecca E. Papendick, Juergen Schumacher, Bruce L. Homer, and Paul Wollenman. "Cerebellar Herniation in Captive Lions (Panthera Leo)." Journal of Veterinary Diagnostic Investigation 11, no. 5 (September 1999): 465–68. http://dx.doi.org/10.1177/104063879901100514.

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16

Leonardi, L., E. Lepri, S. Nannarone, and O. Mechelli. "Fibroblastic osteosarcoma in a lion (Panthera leo)." Open Veterinary Journal 5, no. 2 (2014): 1. http://dx.doi.org/10.5455/ovj.2014.v4.i1.p1.

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This report describes a case of spontaneous fibroblastic osteosarcoma in the humerus of a lion from a private park in Perugia, Italy. The tumor had an irregular, smooth, brown surface and a generally firm, rubbery consistence with gritty to hard areas interspersed. The mass was poorly vascularized with areas of necrosis at the periphery. The cut surface showed a multilobulated mass that had breached the humeral cortex, with periosteal production of reactive bone. The mass invaded the epiphysis, the synovial membrane, the joint capsule and ligaments. A mild hemorrhagic effusion appeared in the joint space. Clinical signs, gross and histopathologic findings are described in this rare case of a malignant bone tumor.
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17

Larsson, Maria Helena Matiko Akao, Auddrey Sismotto Flores, José Daniel Luzes Fedullo, Rodrigo Hidalgo Friciello Teixeira, Regina Mieko Sakata Mirandola, Fumio Honma Ito, Rebecca Bastos Pessoa, and Paula Hiromi Itikawa. "Biochemical parameters of wild felids (Panthera leo and Panthera tigris altaica) kept in captivity." Semina: Ciências Agrárias 38, no. 2 (May 2, 2017): 791. http://dx.doi.org/10.5433/1679-0359.2017v38n2p791.

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Most populations of wild felines are now considered endangered or near extinction due to the indiscriminate hunting and the reduction of their natural habitat, caused by man. Due to the limited number of animals within a population, these species are especially vulnerable to the impacts of diseases and endogamy. In addition, wild felines are also susceptible to metabolic and behavioral changes related to a change in their natural conditions, habitat, and feeding, when the animal enters into captivity. There are few descriptions in the literature of the serum biochemistries of lions and tigers. This study presents the biochemical parameters of 23 captive lions (Panthera leo) and 10 captive Siberian tigers (Panthera tigris altaica) from the Zoological Park of the Sao Paulo Foundation. Serum urea, creatinine, total protein, albumin, total, direct and indirect bilirubin were measured. In addition, serum levels of ALT, AST, ALP, GGT, glucose, CK, lactate dehydrogenase, cholesterol, and triglycerides were determined, as well as calcium, phosphorus, chlorine, sodium, and potassium. Biochemical parameters did not differ significantly among males and females lions, but higher albumin values were observed in male Panthera tigris altaica in comparison to females. The values obtained in this study may be used as reference for captive individuals of Panthera leo and Panthera tigris altaica.
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18

Costa, Eliesse Pereira, Fabiano da Silva Flores, Guilherme Rech Cassanego, Priscila Inês Ferreira, Josiele Milena de Souza, and Luciana Silveira Flôres. "Aspectos morfológicos da glândula molar em leão (Panthera leo)/ Morphological aspects of the molar gland in lion (Panthera leo)." Brazilian Journal of Development 7, no. 9 (September 7, 2021): 87614–21. http://dx.doi.org/10.34117/bjdv7n9-090.

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19

Lucena, Ricardo B., Rafael A. Fighera, Adriano B. Carregaro, Maria Andréia Inkelmann, and Claudio S. L. Barros. "Carcinoma bronquíolo-alveolar em leão-africano (Panthera leo)." Pesquisa Veterinária Brasileira 30, no. 6 (June 2010): 479–83. http://dx.doi.org/10.1590/s0100-736x2010000600002.

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Um caso de carcinoma bronquíolo-alveolar difuso do tipo misto foi diagnosticado em um leão-africano (Panthera leo), hospitalizado com sinais de dispnéia e emagrecimento progressivo. Em todos os lobos pulmonares havia múltiplos nódulos esbranquiçados, macios e homogêneos, de 0,2-0,5cm em diâmetro. Histologicamente, os nódulos eram constituídos por células neoplásicas arranjadas em alvéolos e papilas sustentados por moderado estroma fibrovascular, um padrão que lembrava a estrutura pulmonar pré-existente. Na reação pelo ácido periódico de Schiff (PAS) foi observada marcação positiva no citoplasma de numerosas células neoplásicas. Todas as células neoplásicas demonstraram forte e uniforme imunorreatividade citoplasmática para pancitoceratina. A marcação para o fator 1 de transcrição da tireóide (TTF-1) foi observada em focos nos núcleos das células neoplásicas das margens dos nódulos. Nas secções avaliadas para surfactante A, a marcação foi observada em múltiplas áreas focais, tanto no citoplasma como na membrana citoplasmática das células neoplásicas. O diagnóstico de carcinoma bronquíolo-alveolar difuso do tipo misto foi feito com base nos achados histológicos, histoquímicos e imuno-histoquímicos. Essa parece ser a primeira descrição de um neoplasma pulmonar primário maligno em leão-africano.
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20

Ricci, Emanuele, Paolo Cavicchio, and Carlo Cantile. "Fibrocartilaginous Embolic Myelopathy in a Lion (Panthera leo)." Journal of Zoo and Wildlife Medicine 41, no. 2 (June 2010): 334–37. http://dx.doi.org/10.1638/2009-0101r.1.

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21

Andersen,, K. F. "Urinary Volatile Constituents of the Lion, Panthera leo." Chemical Senses 24, no. 2 (April 1, 1999): 179–89. http://dx.doi.org/10.1093/chemse/24.2.179.

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22

Hartman, Marthinus J., Eric Monnet, Robert M. Kirberger, Leon J. Venter, Lynette Bester, Martin L. Schulman, Tania Serfontein, Retha Fourie, and Johan P. Schoeman. "Laparoscopic Sterilization of the African Lioness (Panthera leo)." Veterinary Surgery 42, no. 5 (January 8, 2013): 559–64. http://dx.doi.org/10.1111/j.1532-950x.2012.01049.x.

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23

Smuts, G. L., J. L. Anderson, and J. C. Austin. "Age determination of the African lion (Panthera leo)." Journal of Zoology 185, no. 1 (August 20, 2009): 115–46. http://dx.doi.org/10.1111/j.1469-7998.1978.tb03317.x.

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24

Garcia-Gonzalez Beatriz, B., and N. Cuesta-Garcia. "Multiseptate Gallbladder in an African Lioness (Panthera leo)." Journal of Comparative Pathology 148, no. 1 (January 2013): 89. http://dx.doi.org/10.1016/j.jcpa.2012.11.175.

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25

Sharma, Anil K., Monalisa Sahoo, and M. Karikalan. "Cloisonné kidney in an Asiatic lion (Panthera leo)." Indian Journal of Veterinary Pathology 39, no. 3 (2015): 293. http://dx.doi.org/10.5958/0973-970x.2015.00073.5.

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26

Ruiz de Ybanez, M. R., C. Martinez-Carrasco, J. J. Martinez, J. M. Ortiz, T. Attout, and O. Bain. "Dirofilaria immitis in an African lion (Panthera leo)." Veterinary Record 158, no. 7 (February 18, 2006): 240–42. http://dx.doi.org/10.1136/vr.158.7.240.

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27

de Manuel, Marc, Ross Barnett, Marcela Sandoval-Velasco, Nobuyuki Yamaguchi, Filipe Garrett Vieira, M. Lisandra Zepeda Mendoza, Shiping Liu, et al. "The evolutionary history of extinct and living lions." Proceedings of the National Academy of Sciences 117, no. 20 (May 4, 2020): 10927–34. http://dx.doi.org/10.1073/pnas.1919423117.

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Lions are one of the world’s most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old cave lions (Panthera leo spelaea), 12 historic lions (Panthera leo leo/Panthera leo melanochaita) that lived between the 15th and 20th centuries outside the current geographic distribution of lions, and 6 present-day lions from Africa and India. We found that cave and modern lions shared an ancestor ca. 500,000 y ago and that the 2 lineages likely did not hybridize following their divergence. Within modern lions, we found 2 main lineages that diverged ca. 70,000 y ago, with clear evidence of subsequent gene flow. Our data also reveal a nearly complete absence of genetic diversity within Indian lions, probably due to well-documented extremely low effective population sizes in the recent past. Our results contribute toward the understanding of the evolutionary history of lions and complement conservation efforts to protect the diversity of this vulnerable species.
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28

Argant, Alain, and Jean-Philip Brugal. "The cave lion Panthera (Leo) spelaea and its evolution: Panthera spelaea intermedia nov. subspecies." Acta Zoologica Cracoviensia 60, no. 2 (December 29, 2017): 58–103. http://dx.doi.org/10.3409/azc.60_2.59.

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29

Kumar, Vijay, and Anshu Raj. "Management of wound myiasis in a lion (panthera leo)." International Journal for Agro Veterinary and Medical Sciences 6, no. 1 (2012): 4. http://dx.doi.org/10.5455/ijavms.11680.

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30

Montellano-Ballesteros, Marisol, and Gerardo Carbot-Chanona. "Panthera leo atrox (Mammalia: Carnivora: Felidae) in Chiapas, Mexico." Southwestern Naturalist 54, no. 2 (May 2009): 217–22. http://dx.doi.org/10.1894/clg-20.1.

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31

Murer, L., M. B. Ribeiro, L. Machado, L. Sagave, G. D. Kommers, G. J. N. Galiza, N. Moreira, and M. Lovato. "Piometra em uma leoa (Panthera leo): relato de caso." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 67, no. 3 (June 2015): 727–31. http://dx.doi.org/10.1590/1678-4162-8154.

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A piometra é uma infecção aguda ou crônica do útero que ocorre frequentemente em cadelas não castradas, podendo também ocorrer em gatas domésticas e selvagens, sendo poucos os estudos relacionados à piometra em grandes felídeos. O objetivo deste relato foi descrever um caso de piometra em uma leoa (Panthera leo) de cativeiro, as lesões de necropsia e histológicas, bem como os resultados da análise microbiológica. Uma leoa com aproximadamente 23 anos, pertencente a um criadouro conservacionista de Santa Maria-RS, foi encontrada morta pela manhã em seu recinto. Após coleta de dados, procedeu-se à necropsia e à coleta de material para análise histopatológica e bacteriológica. A análise microbiológica revelou predomínio das bactérias Streptococcus sp. e Escherichia coli no conteúdo purulento do útero, caracterizando como piometra, e a bactéria predominante em plasma, fígado e medula óssea foi E. coli. De acordo com o laudo histopatológico, as alterações observadas nessa leoa sugerem um quadro de septicemia grave, sendo a origem do foco infeccioso bacteriano, provavelmente, a piometra. Considera-se importante chamar a atenção dos médicos veterinários de animais selvagens para um diagnóstico precoce dessa doença, que é comum em cadelas, mas que pode acometer também felídeos selvagens e levá-los à morte.
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32

Bharathidasan, Murugan, Benjamin Justin William, Ramamurthy Jayaprakash, Thandavan Arthanari Kannan, Rajarthanam Thirumurugan, and Ravi Sundar George. "Immobilization and Anaesthesia in Asiatic Lions (Panthera leo persica)." Advances in Animal and Veterinary Sciences 4, no. 3 (March 4, 2016): 134–44. http://dx.doi.org/10.14737/journal.aavs/2016/4.3.134.144.

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33

Dolrenry, Stephanie, Jennifer Stenglein, Leela Hazzah, R. Scott Lutz, and Laurence Frank. "A Metapopulation Approach to African Lion (Panthera leo) Conservation." PLoS ONE 9, no. 2 (February 5, 2014): e88081. http://dx.doi.org/10.1371/journal.pone.0088081.

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34

Scaglione, F. E., C. Schröder, G. Degiorgi, O. Zeira, and E. Bollo. "Cranial Malformations in Related White Lions (Panthera leo krugeri)." Veterinary Pathology 47, no. 6 (September 8, 2010): 1095–99. http://dx.doi.org/10.1177/0300985810382518.

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35

Das, Dilip Kumar, G. Srinivas Murthy, and Narayana Bhattacherjee. "Management of posterior paresis in a lion (Panthera leo)." Zoos' Print Journal 20, no. 3 (February 21, 2005): 1822. http://dx.doi.org/10.11609/jott.zpj.1134.1822.

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36

Ravindran, Reghu, Bindu Lakshmanan, S. Anoop, T. S. Rajeev, and C. N. Dinesh. "Parasitic infection in captive lions (Panthera leo) at Wyanad." Zoos' Print Journal 21, no. 4 (March 21, 2006): 2230. http://dx.doi.org/10.11609/jott.zpj.1438.2230.

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37

Eloff, F. C. "THE LIFE OF THE KALAHARI LION (PANTHERA LEO VERNAYI)." Transactions of the Royal Society of South Africa 53, no. 2 (January 1998): 267–69. http://dx.doi.org/10.1080/00359199809520393.

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38

Bollo, E., F. E. Scaglione, M. Tursi, C. Schröder, G. Degiorgi, E. Belluso, S. Capella, and D. Bellis. "Malignant pleural mesothelioma in a female Lion (Panthera leo)." Research in Veterinary Science 91, no. 1 (August 2011): 116–18. http://dx.doi.org/10.1016/j.rvsc.2010.08.005.

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39

Bruche, Susann, Markus Gusset, Sebastian Lippold, Ross Barnett, Klaus Eulenberger, Jörg Junhold, Carlos A. Driscoll, and Michael Hofreiter. "A genetically distinct lion (Panthera leo) population from Ethiopia." European Journal of Wildlife Research 59, no. 2 (October 9, 2012): 215–25. http://dx.doi.org/10.1007/s10344-012-0668-5.

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40

Negrini, J., R. Guerra, J. Ruiz, M. Novales, B. Blanco, A. Diz, and E. Mozos. "Multiple Malformations in Non-related Captive Lions (Panthera leo)." Journal of Comparative Pathology 148, no. 1 (January 2013): 89. http://dx.doi.org/10.1016/j.jcpa.2012.11.174.

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41

Karlstam, E., and M. Goczkowski. "Syringomyelia in Two Asian Lion (Panthera leo persica) Siblings." Journal of Comparative Pathology 154, no. 1 (January 2016): 100. http://dx.doi.org/10.1016/j.jcpa.2015.10.106.

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42

Tende, Talatu, Staffan Bensch, Ulf Ottosson, and Bengt Hansson. "Dual phylogenetic origins of N igerian lions ( Panthera leo )." Ecology and Evolution 4, no. 13 (June 11, 2014): 2668–74. http://dx.doi.org/10.1002/ece3.1116.

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43

Schramm, Ralph Dee, Michael B. Briggs, and Jerry J. Reeves. "Spontaneous and induced ovulation in the lion (Panthera leo)." Zoo Biology 13, no. 4 (1994): 301–7. http://dx.doi.org/10.1002/zoo.1430130403.

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44

Vercammen, F., No author No author, J. Brandt, L. Brantegem, and L. Ducatelle. "Haemangiosarcoma in a captive Asiatic lion (Panthera leo persica)." Open Veterinary Journal 5, no. 2 (2015): 52. http://dx.doi.org/10.5455/ovj.2015.v5.i1.p52.

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A 2.7-year-old male captive Asiatic lion (Panthera leo persica) died unexpectedly without preceding symptoms. Gross necropsy revealed liver and lung tumours, which proved to be haemangiosarcomas by histopathology. Some of the liver tumours were ruptured, leading to massive intra-abdominal haemorrhage and death. Haemangiosarcomas are rare in domestic and exotic felids, occurring in skin, thoracic-abdominal cavity and bones. Although these tumours mainly appear to be occurring in older cats, they are sometimes observed in younger animals, as in the present case. This is the first description of haemangiosarcoma in a young Asiatic lion.
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45

Meoli, R., C. Eleni, P. Cavicchio, MC Tonnicchia, B. Biancani, L. Galosi, and G. Rossi. "B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo)." Veterinární Medicína 63, No. 9 (September 18, 2018): 433–37. http://dx.doi.org/10.17221/144/2017-vetmed.

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A 15-year-old female African lion (Panthera leo) maintained at the Zoological Garden of Pistoia, Tuscany (Italy), showed signs of malaise, dyspnoea, tremors, pale mucous membranes and ataxia for two days prior to death. Complete blood count showed anaemia, thrombocytopaenia and severe lymphocytosis. At autopsy, the most relevant finding was severe, generalised splenomegaly. Histologically, high numbers of neoplastic lymphocytes diffusely infiltrated the spleen, liver, heart, pancreas, kidney and lungs. The lymphoid cells were positive for CD79a and negative for CD3 on immunohistochemistry. The histologic features of the neoplastic cells and their immunophenotype are consistent with B-cell lymphocytes. Based on surface membrane co-expression of immunoglobulin M and immunoglobulin D in most neoplastic cells, which indicated that they were naïve, antigen-inexperienced and mature circulating resting B-cells, and consistent with their appearance as small lymphocytes with high nuclear-to-cytoplasmic ratios, a diagnosis of B-cell chronic lymphocytic leukaemia was made.
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46

Larsson, Maria Helena M. A., Fernanda M. Coelho, Valéria M. C. Oliveira, Fernanda L. Yamaki, Guilherme G. Pereira, Elaine C. Soares, José Daniel L. Fedullo, Roberto C. Pereira, and F. H. Ito. "Electrocardiographic Parameters of Captive Lions (Panthera leo) and Tigers (Panthera tigris) Immobilized with Ketamine Plus Xylazine." Journal of Zoo and Wildlife Medicine 39, no. 3 (September 2008): 314–19. http://dx.doi.org/10.1638/2007-0028.1.

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47

Duarte, Margarida D., Sílvia C. Barros, Margarida Henriques, Teresa Lobo Fernandes, Rui Bernardino, Madalena Monteiro, and Miguel Fevereiro. "Fatal Infection with Feline Panleukopenia Virus in Two Captive Wild Carnivores (Panthera tigris and Panthera leo)." Journal of Zoo and Wildlife Medicine 40, no. 2 (June 2009): 354–59. http://dx.doi.org/10.1638/2008-0015.1.

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48

Reilly, Sabrina, M. Reza Seddighi, James C. Steeil, Patricia Sura, Jacqueline C. Whittemore, Rebecca E. Gompf, Sarah B. Elliott, and Edward C. Ramsay. "SELECTED CLINICAL, BIOCHEMICAL, AND ELECTROLYTE ALTERATIONS IN ANESTHETIZED CAPTIVE TIGERS (PANTHERA TIGRIS) AND LIONS (PANTHERA LEO)." Journal of Zoo and Wildlife Medicine 45, no. 2 (June 2014): 328–34. http://dx.doi.org/10.1638/2013-0202r.1.

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49

Eikelberg, Deborah Johanna, Lisa Allnoch, Pierre Grothmann, Julia Bohner, and Marion Hewicker-Trautwein. "Subcutaneous fibrosarcomas with pulmonary metastases in a white tiger (Panthera tigris) and a lion (Panthera leo)." Veterinary Record Case Reports 8, no. 2 (April 2020): e000960. http://dx.doi.org/10.1136/vetreccr-2019-000960.

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Two cases of recurrent subcutaneous fibrosarcomas in a white tiger and a lion were observed and the animals were euthanised humanely due to clinical deterioration. In both animals, postmortem examination revealed multinodular, white to fawn, firm to greasy, subcutaneous masses at the left side of the thorax infiltrating into the adjacent musculature. Furthermore, the tiger showed a single mass and the lion multiple masses in the lung. Histopathologically, the subcutaneous and pulmonary masses consisted of spindle-shaped neoplastic cells with necrotic areas, and infiltration with multinucleated giant cells and lymphocytes. Immunohistochemically, tumour cells labelled positive for vimentin and negative for desmin, factor VIII-related antigen, smooth muscle actin S100, CD31 and nerve growth factor receptor p75. Thus, the pulmonary tumours were diagnosed as metastases of subcutaneous fibrosarcomas. Like domestic cats, also large, non-domestic felids could be predisposed for metastasising fibrosarcoma, which may be associated with injections or trauma.
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50

Jahan, Meeno, Aftab Ahmed, Gerhard Braunitzer, Zafar H. Zaidi, and Reinhard Göltenboth. "Carnivora: The Primary Structures of Adult Lion (Panthern leo) Hemoglobins." Zeitschrift für Naturforschung B 42, no. 11 (November 1, 1987): 1465–70. http://dx.doi.org/10.1515/znb-1987-1116.

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Complete amino acid sequences of lion (Panthera leo) hemoglobins are reported. Polyacrylamide gel disc electrophoresis at pH 8.3 and also in the presence of 8 M urea and Triton-X100, RP-HPLC, liquid and gas phase amino acid sequenator. and FAB Mass spectrometer are used. Sequences are aligned with human hemoglobin (Hb A ) and compared with other hemoglobins of felidae.
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