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Dissertations / Theses on the topic 'Paper-based microfluidics'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Terblanche, Johannes C. "Modified polysaccharide-based particles for strengthening paper." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5376.

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Thesis (PhD (Process Engineering))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: The ongoing trend in papermaking industries is to lower production costs by increasing the low cost filler content in the sheets. However, the disruption of inter-fibre bonding is accompanied by a deterioration of paper stiffness and mechanical properties if filler content exceeds 18 wt%. Polysaccharide solutions, such as starch, are often used as a low cost biodegradable additive to improve internal sheet strength when added to the wet-end of production. The amount of starch that can be added is ho

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2

Clayton, Katherine Noel. "Comparing Anti-VEGF Antibodies and Aptamers on Paper Microfluidic-Based Platforms." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/765.

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The field of microfluidics is expanding into what is known as paper microfluidics. This uses a paper platform rather than materials (i.e. PDMS, PMMA) that are commonly used in microfluidics research. Current devices require an expensive manufacturing process and external sources to power the device. Such devices are not practical in low resource environments. As a consequence, it is the goal of this Thesis to develop a three-dimensional, multiplexed assay chip using nitrocellulose membranes. This device comprises of multiple layers of nitrocellulose membranes with defined fluidic channels. The

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3

Li, Hua. "Qualitative Blood Coagulation Test Using Paper-Based Microfluidic Lateral Flow Device." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406810864.

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4

Shen, Liuliu [Verfasser], J. M. Bastian [Akademischer Betreuer] Etzold, and Markus [Akademischer Betreuer] Biesalski. "Paper-based Microfluidics for Electrochemical Applications / Liuliu Shen ; J. M. Bastian Etzold, Markus Biesalski." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1211478149/34.

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Shen, Liuliu [Verfasser], J. M. Bastian Akademischer Betreuer] Etzold, and Markus [Akademischer Betreuer] [Biesalski. "Paper-based Microfluidics for Electrochemical Applications / Liuliu Shen ; J. M. Bastian Etzold, Markus Biesalski." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://nbn-resolving.de/urn:nbn:de:tuda-tuprints-117737.

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6

Ward, Jennifer Guerin. "Nitrocellulose Paper Based Microfluidic Platform Development and Surface Functionalization with Anti-IgE Aptamers." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/746.

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The purpose of this thesis project was to demonstrate the ability to utilize the capabilities of aptamers so that they may act as capture reagents for paper microfluidic devices. Several characterization experiments were conducted as a precursor before the final experimentation was performed. Paper characterization, manufacturing protocols for printing and heating, as well as 3D chip fabrication were all performed and analyzed. The results confirmed that the control of fluid through a 3D microfluidic device based in nitrocellulose is possible. For the biochemistry portion of this thesis rep

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7

Murdock, Richard C. "Development of Microfluidic Paper-based Analytical Devices for Point-of-Care Human Physiological and Performance Monitoring." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439308025.

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8

Holler, Alicia Leanne. "Functional 3-D Cellulose and Nitrocellulose Paper-based, Microfluidic Device Utilizing ELISA Technology for the Detection/Distinction Between Hemorrhagic and Ischemic Strokes." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1707.

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The purpose of this thesis project is to demonstrate and evaluate an enzyme-linked immunosorbent assay (ELISA) on a paper microfluidic device platform. The integration of ELISA technology onto paper microfluidic chips allows for a quantitative detection of stroke biomarkers, such as glial fibrillary acidic protein (GFAP). Dye experiments were performed to confirm fluid connectivity throughout the 3D chips. Several chip and housing designs were fabricated to determine an optimal design for the microfluidic device. Once this design was finalized, development time testing was performed. The resul

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9

Klasner, Scott A. "Novel capillary and microfluidic devices for biological analyses." Diss., Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3747.

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10

Glavan, Ana. "Chemical Approaches to the Surface Engineering of Paper and Cellulose-Based Materials for Microfluidics, Electronics and Low-Cost Diagnostics." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718749.

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Paper (and other cellulose-based materials such as cotton thread and fabrics) are underexploited as materials for the construction of “high-tech” and “lab-on-a-chip” devices. One major drawback of paper is its tendency to absorb water from the environment and, with wetting, to change its mechanical properties; other challenges relate to control over the attachment of molecules (e.g. antibodies, DNA) and cells on its surface, and to the addition of electronic function. The goal of this thesis is to develop paper as a substrate for a range of applications— microfluidics, substrates for electroni

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Tageson, Mackenzie Elizabeth. "FUNCTIONAL 3-D CELLULOSE & NITROCELLULOSE PAPER-BASED, MULITPLEX DIAGNOSTIC PLATFORMS WITHOUT COUPLING AGENTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1128.

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The purpose of this thesis was to demonstrate device functionality of 3-D paper-based, multiplex platforms, µPADs, without the use of coupling agents between layers. Previously, these platforms were fabricated with double-sided tape and cellulose powder to try to augment proper fluid routing, but difficulties with this method occurred. An acrylic housing unit with strategically placed pressure tabs was designed to aid horizontal and vertical fluid routing through the platform, thus eliminating the inconsistencies associated with coupling agents. Channel characterization studies, a COMSOLTM sim

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12

Barbosa, Luís Miguel Marques. "Production and characterization of the fusion ZZapo-CBM64 for the capture and detection of apolipoprotein-A1 in paper tests." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22709.

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Mestrado em Bioquímica - Métodos Biomoleculares<br>Affibodies (ZZ) são pequenas proteínas de afinidade que podem ser modificadas para se ligarem a alvos específicos. Estas proteínas têm sido sugeridas como uma alternativa a anticorpos, devido ao seu processo de produção mais simples e barato. Assim, o objetivo deste trabalho de mestrado visou a possibilidade da utilização de um affibody (ZZapo) para a captura da Apolipoproteina-A1 (Apo-A1) e sua deteção com anticorpos Anti-Apo-A1 conjugados com Nanopartículas de Ouro (AuNPs) num Dispositivo Microfluídico Analítico de Papel (μPAD). Para atingir

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13

Pokpas, Keagan William. "Microfluidic graphenised-paper electroanalytical devices (μGPED) for adsorptive cathodic stripping voltammetric detection of metal contaminants". University of the Western Cape, 2017. http://hdl.handle.net/11394/5506.

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Philosophiae Doctor - PhD<br>The need for clean, non-toxic drinking water supplies, free of pollutants and metal contamination is vital in impoverished areas and the developing world alike. With this in mind, the development of accurate, inexpensive, portable and simple devices for remote sensing applications is therefore pivotal for early detection and the prevention of illnesses. Over the last two decades, adsorptive stripping voltammetry (AdSV) has emerged as a superior detection method over common analytical techniques due to its low-cost instrumentation, unskilled labour and ability

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14

Louw, Clementine Juliat. "Microfluidic paper based electrochemical sensing devices." University of the Western Cape, 2019. http://hdl.handle.net/11394/7000.

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>Magister Scientiae - MSc<br>Microfluidic paper based electrochemical sensing devices (μPEDs) provides a new way for point of care testing (POCT). μPEDs offer an inexpensive, portable, easy to use technology too monitor the environment and diagnose diseases, especially in developing countries in cases where there is not enough infrastructure and a limited trained medical and health professionals. The aim of this work is to develop a paper based electrode which can be further integrated into a microfluidic paper device to develop miniature point of care devices. Paper was used as a substr

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15

Ciniciato, Gustavo Pio Marchesi Krall. "Desenvolvimento de biocélulas a combustível de glicose/oxigênio em microfluídica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/75/75134/tde-23042013-105430/.

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O objetivo principal desta tese foi o de se desenvolver uma biocélula a combustível enzimática em microfluídica, utilizando a glicose como combustível e o oxigênio como oxidante. Foram utilizadas as enzimas Glicose Oxidase ou Glicose Desidrogenase em um bioânodo, de forma a promover reações bioeletrocatalíticas de oxidação da glicose e as enzimas Lacase ou Bilirrubina Oxidase, de forma a promover reações bioeletrocatalíticas de redução do oxigênio molecular. O trabalho se procedeu por tentativas de imobilizar estas enzimas, de forma a promover o mecanismo de transferência eletrônica direta

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16

Morbioli, Giorgio Gianini. "Funcionalização de celulose para ensaios bioanalíticos em dispositivos microfluídicos baseados em papel (μPADs)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-23062015-105938/.

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A funcionalização da matriz celulósica é um ponto essencial para o aprimoramento dos dispositivos microfluídicos baseados em papel (µPADs). Ela permite minimizar o preparo de amostras e a interferência do usuário, principais fontes de erro no processo analítico. A oxidação da celulose durante uma hora com m-periodato de sódio e a imobilização química de enzimas a partir da formação de bases de Schiff (iminas), via a adição direta da enzima ao substrato oxidado sem a necessidade de outras etapas, é um processo rápido e de baixo custo, apresentando grande potencialidade de aplicação nos di

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17

Liu, Cheyenne H. "Development and Characterization of Reagent Pencils for Microfluidic Paper Based Analytical Devices." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1639.

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Microfluidic paper based analytical devices (microPADs) are a novel platform for point of care (POC) diagnostics. Limitations of reagent shelf life have been overcome with the introduction of reagent pencils as a method for solid-based reagent deposition. While useful, little work has been reported on the characterization and optimization of reagent pencils. Herein, an investigation on reagent pencil composition and efficiency is conducted via colorimetric release profile tests utilizing an erioglaucine disodium salt that yields a quantifiable blue colored product in the presence of water. Wit

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Mitchell, Haydn Thomas. "AN INVESTIGATION OF POLY(N-ISOPROPYLACRYLAMIDE) FOR APPLICATIONS WITH MICROFLUIDIC PAPER-BASED ANALYTICAL DEVICES." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1248.

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N,N′-methylenebisacrylamide-crosslinked poly(N-isopropylacrylamide), also known as P(NIPAM), was developed as a fluid delivery system for use with microfluidic paper-based analytical devices (microPADs). MicroPADs are postage-stamp-sized devices made out of paper that can be used as platforms for low-cost, simple-to-use point-of-care diagnostic assays. P(NIPAM) is a thermally responsive polymer that absorbs aqueous solutions at room temperature and will expel the solutions to microPADs when heated. The fluid delivery characteristics of P(NIPAM) were assessed, and P(NIPAM) was able to deliver m

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Santhiago, Murilo 1984. "Construção e aplicação de dispositivos analíticos 2D e 3D à base de papel com detecção eletroquímica." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248388.

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Orientador: Lauro Tatsuo Kubota<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-24T12:03:31Z (GMT). No. of bitstreams: 1 Santhiago_Murilo_D.pdf: 3375339 bytes, checksum: 5d945dd23cfef732a3e3d083685bedc0 (MD5) Previous issue date: 2014<br>Resumo: Neste trabalho descreve-se a construção e aplicação de dispositivos analíticos 2D e 3D à base de papel com detecção eletroquímica (ePAD). Os dispositivos foram construídos empregando o método de impressão com cera e diferentes tipos de papéis. Eletrodos de ouro foram utilizados junt

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20

Busin, Valentina. "The development of microfluidic paper-based analytical devices for point-of-care diagnosis of sheep scab." Thesis, Heriot-Watt University, 2017. http://hdl.handle.net/10399/3263.

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The recent growing interest and development of microfluidic paper-based analytical devices (μPADs) for point-of-care (POC) testing in human health in low-resource settings has great potential for the exploitation of these technologies in animal disease diagnosis. Sheep scab is a highly infectious, widespread and notifiable disease of sheep, which poses major economic and welfare concerns for the UK farming industry. The possibility of diagnosing sheep scab at the POC is, consequently, very important to controlling this disease. The overall aim of this project was, therefore, to develop μPADs b

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21

Chaplan, Cory A. "Stabilization of Horseradish Peroxidase Using Epoxy Novolac Resins for Applications with Microfluidic Paper-Based Analytical Devices." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1252.

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Microfluidic paper-based analytical devices (microPADs) are an emerging platform for point-of-care diagnostic tests for use by untrained users with potential applications in healthcare, environmental monitoring, and food safety. These devices can be developed for a multitude of different tests, many of which employ enzymes as catalysts. Without specialized treatment, some enzymes tend to lose their activity when stored on microPADs within 48 hours, which is a major hurdle for taking these types of devices out of the laboratory and into the real world. This work focused on the development of si

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22

Jain, Ishan. "Paper-Based Sensors for Contaminant Detection Using Surface Enhanced Raman Spectroscopy." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/53946.

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Surface enhanced Raman spectroscopy (SERS) is highly promising analytical technique for trace detection of analytes. It is particularly well suited for environmental analyses due to its high sensitivity, specificity, ease of operation and rapidity. The detection and characterization of environmental contaminants, using SERS is highly related to the uniformity, activity and reproducibility of the SERS substrate. In this thesis, SERS substrates were produced by gold nanoparticle formation on wax patterned chromatography paper. In situ reduction of hydrogen tetrachloroaurate (gold precursor) b

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23

Schultz, Spencer A. "An Investigation into the Use of Polymer Bound Boronic Acid for Glucose Detection in Paper Based Microfluidic Devices." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1611.

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Paper Based Microfluidic Devices (microPADs) are a new platform for point-of-care diagnostic assays for use in resource-limited settings. These devices rely typically on enzymatic assays to produce their results, which makes them susceptible to degradation when exposed to extreme environmental conditions such as high temperature. In order to overcome this limitation, this research project focused on investigating the use of polymers instead of enzymes to detect analytes on microPADs. Polymer-bound boronic acid, a glucose and pH sensitive polymer, was incorporated into microPADs in order to dev

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Kripalani, Rishi A. "Novel Integration of Conductive-ink Circuitry with a Paper-based Microfluidic Battery as an All-printed Sensing Platform." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1694.

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The addition of powered components for active assays into paper-based analytical devices opens new opportunities for medical and environmental analysis in resource-limited applications. Current battery designs within such devices have yet to adopt a ubiquitous circuitry material, necessitating investigation into printed circuitry for scalable platforms. In this study, a microfluidic battery was mated with silver-nanoparticle conductive ink to prototype an all-printed sensing platform. A multi-layer, two-cell device was fabricated, generating 200 μA of direct electrical current at 2.5 V sustain

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Ismail, Abdul Ghani. "Miniaturized devices for bioanalysis : case of nitric oxide stored as S-nitrosothiols in biological fluids." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066357/document.

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Les S-nitrosothiols (RSNOs) sont considérés comme des stocks circulant de monoxyde d'azote (NO) et qui ont de nombreux rôles in vivo. Une variation de la proportion des taux de RSNOs a été démontrée dans de nombreuses maladies. Il est donc important de pouvoir identifier et quantifier chaque RSNO dans les fluides biologiques pour la réalisation de diagnostics médicaux. Il devient alors intéressant de développer des outils analytiques pour la détermination des RSNOs, en utilisant de faibles volumes d'échantillons biologiques. Ce travail de thèse a ainsi été orienté vers le développement d'outil

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Lahr, Rebecca Halvorson. "Advanced Applications of Raman Spectroscopy for Environmental Analyses." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54010.

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Due to an ever-increasing global population and limited resource availability, there is a constant need for detection of both natural and anthropogenic hazards in water, air, food, and material goods. Traditionally a different instrument would be used to detect each class of contaminant, often after a concentration or separation protocol to extract the analyte from its matrix. Raman spectroscopy is unique in its ability to detect organic or inorganic, airborne or waterborne, and embedded or adsorbed analytes within environmental systems. This ability comes from the inherent abilities of the Ra

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Shen, Liuliu. "Paper-based Microfluidics for Electrochemical Applications." Phd thesis, 2020. https://tuprints.ulb.tu-darmstadt.de/11773/1/19-11-26%20PHD%20thesis%20Liu-Liu%20Shen.pdf.

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Paper-based microfluidic platforms enable miniaturization and integration of various reaction processes and technologies into on-chip devices, aiming at fabricating a broad range of low cost custom products of our daily life. This dissertation focuses on applying the paper-based microfluidic concept to construct portable and disposable electrochemical devices with simple structure and affordable price. For three examples, their structural features, working principles and electrochemical performance are systematically investigated and discussed. The examples are: 1) a paper-based microfluidic

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Po-ShengChen and 陳柏昇. "Rapid fabrication of paper based microfluidics by microembossing." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/5bzfux.

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YuWang and 王瑀. "Fabrication of Paper-based Microfluidics by One-step Hot Microembossing." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/vkt755.

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碩士<br>國立成功大學<br>化學工程學系<br>107<br>In recent years, microfluidic paper-based analytical device (µPAD) has been receiving attention because it is simple, inexpensive and power-free for low-cost chemical, biological and environmental detection. Moreover, paper is lightweight, easy to stack, store and transport, biodegradable, biocompatible, good for colorimetric tests, flammable for easy disposal of used paper-based diagnostic devices by incineration, and can be chemically modified. Different methods have been demonstrated to fabricate µPADs such as solid wax printing, craft cutting, photolithogra

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Pei, Zhang. "Application of Ion Concentration Polarization to Water Desalination and Active Control of Analytes in Paper." Thesis, 2013. http://hdl.handle.net/1807/43362.

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This thesis focuses on the development of two new applications using ion concentration polarization (ICP): an out-of-plane microfluidic approach for water desalination and a method for concentration and transportation of charged analytes in paper-based biomedical diagnostic device. In the first work, we present an out-of-plane desalination approach using ICP. A depletion boundary separates salt ions and purified water into distinct vertically stacked layers. The out-of-plane design enables multiplexing in three dimensions, providing the functional density required for practical application

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Silva, Miguel Ângelo Alves Gomes dos Santos. "Spectroscopic platform for the classification of pathological states." Master's thesis, 2018. http://hdl.handle.net/10400.14/33835.

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Nos últimos anos, os ensaios de dispositivos analíticos baseados em papel apresentaram um crescimento significativo na indústria de testes de diagnóstico point-of-care (POC) sendo considerados uma tecnologia sólida e robusta. Entre as principais vantagens, estes dispositivos caracterizam-se pela simplicidade, precisão relativa, tempo de retorno rápido, fácil utilização e preço acessível. Tendo em conta estas vantagens, estes testes suscitaram o interesse não só da academia, mas também da indústria levando ao aparecimento de uma grande gama de aplicações (e.g. testes de gravidez, testes de gluc

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Couto, Adriana Miguel Serra Silva. "Development of high-sensitivity colorimetric assay for detection of multiple urinary tract infection biomarkers on diaper." Master's thesis, 2017. http://hdl.handle.net/1822/49606.

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Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica)<br>The invasion and the multiplication of microorganisms like bacteria, viruses and parasites that are not commonly found on the human body may cause infections. Regarding incidence it is important to point out the urinary tract infections (UTI), the second most common kind of infection, making of utmost importance its early detection, diagnosis and swift identification of the most appropriate customized treatment. These infections can be detected using urinalysis that can also handle the d

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Li, Jain-De, and 李建德. "Diagnosis and Fault Tolerance of Paper-Based Microfluidic Biochips." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/2vjkw9.

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Kao, Peng-Kai, and 高鵬凱. "Fabrication of Microfluidic Paper-based Analytical Devices Using Plasma Processes." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/05500605933774590472.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>102<br>In this work, we first demonstrated an all-dry, top-down, and one-step rapid process to fabricate paper-based microfluidic devices using fluorocarbon plasma polymerization. This process is able to create fluorocarbon-coated hydrophobic patterns on filter paper substrates while maintaining the trench and detection regions intact and free of contamination after the fabrication process, as confirmed by ATR-FTIR and XPS. We have shown that the processing time is one critical factor that influences the device performance. For the device fabricated with a sufficien

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Ko, Chien-Hsuan, and 柯建亘. "Rapid Microfluidic Paper-Based System for Sulfur Dioxide Detection in Food." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/s538he.

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碩士<br>國立屏東科技大學<br>材料工程研究所<br>106<br>This study aims to detect the concentration of sulfur dioxide (SO2) in food additives by rapid microfluidic paper-based system. The concept of Lab-on-a-Chip (LOC) and point-of-care (POC) were combined for food inspection. This helped to develop an easily-control and portable rapid detection system. By this method, smartphone is capable of revealing the value of Red Green Blue Color model (RBG) and converting it to the concentration of SO2 after dropping several drops of sample on the reacting area of paper-based chip. The results demonstrate that the lineari

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"Microfluidic Paper-Based Analytical Devices: Sample Preparation, Medical Monitoring and Diagnostics." 2013.

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LIU, YI-WEN, and 劉議文. "Research on the paper-based microfluidic chip for detection of pesticide." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9v73jn.

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碩士<br>明志科技大學<br>機械工程系機械與機電工程碩士班<br>106<br>In pesticide detection, the activity of acetylcholinesterase (AChE) is inhibited, causing AChE to lose its ability to hydrolyze by combining with pesticides. The activity of AChE is reduced when the pesticide concentration is increased. Therefore, yellow 5-thio-2-nitrobenzoate (TNB) products are reduced and the color of the reaction becomes brighter. The toxicity of the pesticide depends on the inhibition of AChE, and such detection methods require the sample to have a fixed reaction time, resulting in a complicated procedure if traditional technology

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WU, PEI-YI, та 吳姵儀. "Development of rapid microfluidic paper-based analytical device（μPAD）of nitrite detection". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/rrfb23.

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碩士<br>國立高雄海洋科技大學<br>水產食品科學研究所<br>106<br>Nitrite is one of the commonly, use preservatives in the food system. Nitrite in the meat products red color and inhibit the growth of Clostridium botulinum. Therefore, is necessary to use nitrite in the food products to ensure safety and maintain color. However, nitrite is a known carcinogen and possesses a potential risk. The traditional analyses of nitrite, include chromatography, electrochemical approach, spectral analysis and capillary electrophoresis etc. Using microfluidic paper-based analytical devices（μPADs）has many advantages such as simple

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Wei-ShuanLi and 李維璿. "Fabrication of microfluidic paper-based analytical devices (µPADs) by filtration-assisted lithography (FilL)." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8r8qgd.

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碩士<br>國立成功大學<br>化學工程學系<br>104<br>In this study, we have proposed and demonstrated a relatively simple and fast technique, i.e. filtration-assisted lithography (FilL) to fabricate paper-based microfluidic devices. The filter paper was first patterned with the tape, followed by dispensing polymer solution on top of the paper and turning on vacuum pump. It was found that the polymer was retained inside the filter paper at the designated locations to form the barrier, i.e. the channel wall. The minimum channel width is approximately 1000 m. When using 22 wt% polymethylmethacrylate solution with

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Yen, Yu-Chun, and 閻侑君. "Rapid Detection of Ketamine in Oral Fluid Using Microfluidic Paper Based Analytical Devices." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/41518009916702411371.

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碩士<br>國立中興大學<br>生醫工程研究所<br>103<br>A novel oral fluid testing platform based on microfluidic paper‐based analytical devices (µPADs) is proposed for on-site high-throughput monitoring of driving under the influence of drug (DUID). A key advantage of the proposed technology is the ability to simultaneously and effectively measure low concentration of ketamine in oral fluid without the need of complex equipment, power sources and long processing time. The detection system will provide key elements including (a) adequate, consistent and high recovery oral fluid collection without dilution, (b) sele

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Wu, Jia-Han, and 吳佳翰. "An Integrated Paper-Based Microfluidic System for Bacterial Detection Utilizing Magnetic-composite-membrane devices." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/z38d4x.

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Chen, Ming Jie, and 陳銘潔. "A paper-based cell culture microfluidic platform for the study of cell-cell interaction." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/47573356211763489463.

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Yang, Shih I., and 楊士奕. "Development of a paper-based carbon nanotube sensing microfluidic system for chemical and biological detection." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/11338221328006063622.

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碩士<br>長庚大學<br>醫療機電工程研究所<br>101<br>Paper-based microfludics is an academically creative research, which can be used in different types of analyses, such as pH, glucose, uric acid and protein. However, sensing electrodes are usually made of metal and its fluidic channels are usually made with SU-8 photolithography or wax. In this study, carbon nanotube(CNT) was proposed to be an alternative material to form the sensing electrode, and combined with a paper-based microfluidic analytical device which was defined by PDMS. In this research, three parts were divided. First, manufacturing of the CNT el

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Chen, Guan-Hua, and 陳冠樺. "Intergration of Gold Nanoparticle Colorimetric Assay and Microfluidic Paper Based Analytical Devices for Mercury Detection." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/48802594449126944286.

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碩士<br>國立中興大學<br>生醫工程研究所<br>101<br>Colorimetric sensing strategy employing gold nanoparticles and a paper assay platform has been developed for inorganic mercury detection in environment. Unmodified gold nanoparticles, 3-mercaptopropionic acid (MPA) and detection single-stranded deoxyribonucleic acid (ssDNA) are used to achieve rapid mercury ion sensing without complicated and time-consuming thiolated or other surface-modified probe preparation processes. To eliminate the use of sophisticated equipment for data analysis, the color variance for multiple detection results was simultaneously colle

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Shih-HaoYeh and 葉世豪. "Sample Preconcentration with High Enrichment Factors in Paper-Based Microfluidic Devices Using Ion Concentration Polarization." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/25805464961166295057.

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CHIANG, CHEN-KUANG, and 江晨光. "Preparation and Evaluation of 3D Printed Microfluidic Paper-based Devices for the Detection of Nitrite and Hemoglobin." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/y5z6ke.

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LIN, PENG-YI, and 林芃儀. "Development of a Microfluidic Paper-based Analytical Device Based On Near-Infrared Emitting Iridium(III) Complex for Glucose Detection In Human Blood." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/9r4t3e.

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碩士<br>東吳大學<br>化學系<br>107<br>The first part is "Development of a portable fluorescent detector", with the increasing number of aging population, our research target has become to develop a simple and a small equipment to achieve real-time monitoring health condition. This article uses 3D printing technology to create a portable fluorometer that can be combined with mobile phones. The portable fluorometer includes a first body part, a second body part and a support body part. The design with the advantages of small size, easy storage, less interference from the scattering light, and low-cast. An

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Ferreira, Francisca Teixeira Soares da Mota. "Design and assembly of microfluidic paper-based analytical devices (μPADS) for the quantification of nitrite and nitrate in saliva". Master's thesis, 2019. http://hdl.handle.net/10400.14/31708.

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Nos últimos anos, investigadores, com o auxílio de novas tecnologias, têm trabalhado para o desenvolvimento de técnicas e dispositivos de diagnóstico e tratamento mais práticos e económicos. Neste trabalho foram desenvolvidos dois dispositivos microfluídicos analíticos baseados em papel (μPADs) para a determinação dos aniões nitrito e nitrato em amostras de saliva humana, para auxílio no diagnóstico de doenças associadas à sua presença. Para desenvolver estes μPADs foram realizados vários estudos de desenho e construção, incluindo um teste de interferências e estudos de estabilidade. A estrutu

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Wu, Chen-Yi, and 吳貞儀. "Coupling of microfluidic paper-based separation devices and time-of-flight secondary ion mass spectroscopy (ToF-SIMS) for analyzing molecular mixtures." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/40587187689657153557.

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碩士<br>國立臺灣大學<br>材料科學與工程學研究所<br>104<br>Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is a promising surface characterization technique that is able to address spectral analysis and direct imaging. With recent development of cluster ion beams, molecular species could also be examined according to their molecular weights without the need of labeling. High spatial resolution images of molecular distribution on a surface could also be acquired via using a focused primary ion scanning over the specimen. Besides, operated within the static regime, the specimen is nearly unaltered after an

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Aguiar, Juliana Isabel Soares. "Design and development of a microfluific paper-based analytical device ( μPAD) for magnesium determination in saliva". Master's thesis, 2019. http://hdl.handle.net/10400.14/31498.

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De todos os catiões presentes no corpo, o magnésio é o segundo mais importante catião e o quarto mais prevalente. Doenças que envolvem o magnésio são classificadas em dois grupos: hipomagnesemia (défice de magnésio) e hipermagnesemia. Desta forma, a determinação de magnésio despertou grande interesse, porque auxilia no contexto clínico e em pesquisas epidemiológicas. Portanto, o objetivo deste trabalho foi desenvolver um dispositivo microfluídico analítico em papel (μPAD) para quantificar magnésio em amostras salivares. Neste caso em concreto, o μPAD baseia-se numa reação colorimétrica entre o

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