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Journal articles on the topic 'Paper-based microfluidics'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Soum, Veasna, Sooyong Park, Albertus Ivan Brilian, Oh-Sun Kwon, and Kwanwoo Shin. "Programmable Paper-Based Microfluidic Devices for Biomarker Detections." Micromachines 10, no. 8 (2019): 516. http://dx.doi.org/10.3390/mi10080516.

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Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.

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2

Abadian, Arash, and Shahin Jafarabadi-Ashtiani. "Paper-based digital microfluidics." Microfluidics and Nanofluidics 16, no. 5 (2014): 989–95. http://dx.doi.org/10.1007/s10404-014-1345-7.

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3

Niedl, Robert R., and Carsten Beta. "Hydrogel-driven paper-based microfluidics." Lab on a Chip 15, no. 11 (2015): 2452–59. http://dx.doi.org/10.1039/c5lc00276a.

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4

Dungchai, Wijitar, Orawon Chailapakul, and Charles S. Henry. "Electrochemical Detection for Paper-Based Microfluidics." Analytical Chemistry 81, no. 14 (2009): 5821–26. http://dx.doi.org/10.1021/ac9007573.

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5

Choi, Gihoon, and Seokheun Choi. "Cellular flow in paper-based microfluidics." Sensors and Actuators B: Chemical 237 (December 2016): 1021–26. http://dx.doi.org/10.1016/j.snb.2015.11.127.

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6

Shen, Liu‐Liu, Gui‐Rong Zhang, and Bastian J. M. Etzold. "Paper‐Based Microfluidics for Electrochemical Applications." ChemElectroChem 7, no. 1 (2019): 10–30. http://dx.doi.org/10.1002/celc.201901495.

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7

Kaya, Kerem, Ahmet Yasin Celik, and Senol Mutlu. "Integration of Paper Based Electro-Osmotic Pumps to Continuous Microfluidic Channels." Proceedings 2, no. 13 (2018): 870. http://dx.doi.org/10.3390/proceedings2130870.

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This work reports for the first-time integration of continuous microfluidic channels to the paper-based electro-osmotic pumps (EOPs) with liquid bridges. In addition, 0.2 μm pore sized cellulose acetate (CA) membrane filter is used to eliminate pressure-driven flow instead of filter paper which is common in paper microfluidics and has an average pore size of 10 μm. A factor of 57 increase in hydraulic resistance is achieved with the new paper. Fabrication of the pumps and microfluidic channels using paper, wax, adhesive film and PMMA plates is explained. Volumetric flow rate of 19 nL/min is achieved in the microfluidic system with 61 V/cm electrical field magnitude applied to DI water. The capability of the integrated system is shown with precise liquid motion in a Y-shaped microfluidic channel integrated with two EOPs.

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8

Liu, Bingwen, Dan Du, Xin Hua, Xiao-Ying Yu, and Yuehe Lin. "Paper-Based Electrochemical Biosensors: From Test Strips to Paper-Based Microfluidics." Electroanalysis 26, no. 6 (2014): 1214–23. http://dx.doi.org/10.1002/elan.201400036.

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9

Gorgannezhad, Lena, Helen Stratton, and Nam-Trung Nguyen. "Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology." Micromachines 10, no. 6 (2019): 408. http://dx.doi.org/10.3390/mi10060408.

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Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this research area has had a broad range of applications. Novel and innovative strategies for detection and identification of bacterial nucleic acids are important for practical applications. Microfluidics is an emerging technology that only requires small amounts of liquid samples. Microfluidic devices allow for rapid advances in microbiology, enabling access to methods of amplifying nucleic acid molecules and overcoming difficulties faced by conventional. In this review, we summarize the recent progress in microfluidics-based polymerase chain reaction devices for the detection of nucleic acid biomarkers. The paper also discusses the recent development of isothermal nucleic acid amplification and droplet-based microfluidics devices. We discuss recent microfluidic techniques for sample preparation prior to the amplification process.

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10

Meredith, Nathan A., Casey Quinn, David M. Cate, Thomas H. Reilly, John Volckens, and Charles S. Henry. "Paper-based analytical devices for environmental analysis." Analyst 141, no. 6 (2016): 1874–87. http://dx.doi.org/10.1039/c5an02572a.

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11

Gerold, Chase T., Eric Bakker, and Charles S. Henry. "Selective Distance-Based K+ Quantification on Paper-Based Microfluidics." Analytical Chemistry 90, no. 7 (2018): 4894–900. http://dx.doi.org/10.1021/acs.analchem.8b00559.

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12

Gao, Zehang, Huo Peng, Minjie Zhu, et al. "A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics." Micromachines 10, no. 5 (2019): 291. http://dx.doi.org/10.3390/mi10050291.

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In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidics. In this paper, the principle, setup and procedure were introduced. Finally, as a demonstration, the strategy was also implemented in a miniaturized picoinjector in order to monitor and control the injection dosage to droplets. We expect that this facile strategy supplies a low-cost yet effective imaging system that can be easily implemented in miniaturized microfluidic systems or general laboratories.

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13

Lim, Jafry, and Lee. "Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices." Molecules 24, no. 16 (2019): 2869. http://dx.doi.org/10.3390/molecules24162869.

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Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages.

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14

Prasad, Alisha, Tiffany Tran, and Manas Gartia. "Multiplexed Paper Microfluidics for Titration and Detection of Ingredients in Beverages." Sensors 19, no. 6 (2019): 1286. http://dx.doi.org/10.3390/s19061286.

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Food safety and access to systematic approaches for ensuring detection of food hazards is an important issue in most developing countries. With the arrival of paper-based analytical devices (µPADs) as a promising, rapid, easy-to-use, and low-cost analytical tool, we demonstrated a simple microfluidic-based titration study for the analysis of packaged fruit juices. Similar, to the titration experiments using traditional glassware in chemistry laboratories, in this study the titration experiments were developed using paper microfluidics for the analysis of several analytes such as pH, vitamin C, sugars, and preservatives present in the packaged fruit juices. The allergen found commonly in dairy based mixtures and the non-pathogenic biochemical component responsible for food spoilage in cider based fruit juices were also determined. The results obtained using paper microfluidics were compared with those obtained using a conventional spectrophotometric technique. Finally, a paper microfluidics based multiplexed sensor was developed for the analysis of common nutritional ingredients, an allergen, and a non-pathogenic byproduct present in packaged fruit juices on a single platform. Overall, the results presented in this study reveal that the proposed paper microfluidic assisted colorimetric multiplexed sensor offers a quick and reliable tool for on-spot routine analysis for food safety applications.

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15

Lin, Yang, Dmitry Gritsenko, Shaolong Feng, Yi Chen Teh, Xiaonan Lu, and Jie Xu. "Detection of heavy metal by paper-based microfluidics." Biosensors and Bioelectronics 83 (September 2016): 256–66. http://dx.doi.org/10.1016/j.bios.2016.04.061.

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16

Nishat, Sumaira, Ali Turab Jafry, Andres W. Martinez, and Fazli Rabbi Awan. "Paper-based microfluidics: Simplified fabrication and assay methods." Sensors and Actuators B: Chemical 336 (June 2021): 129681. http://dx.doi.org/10.1016/j.snb.2021.129681.

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17

Zhang, Yajun, Jingji Liu, Hongliang Wang, and Yiqiang Fan. "Laser-induced selective wax reflow for paper-based microfluidics." RSC Advances 9, no. 20 (2019): 11460–64. http://dx.doi.org/10.1039/c9ra00610a.

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18

Temirel, Mikail, Sajjad Rahmani Dabbagh, and Savas Tasoglu. "Hemp-Based Microfluidics." Micromachines 12, no. 2 (2021): 182. http://dx.doi.org/10.3390/mi12020182.

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Hemp is a sustainable, recyclable, and high-yield annual crop that can be used to produce textiles, plastics, composites, concrete, fibers, biofuels, bionutrients, and paper. The integration of microfluidic paper-based analytical devices (µPADs) with hemp paper can improve the environmental friendliness and high-throughputness of µPADs. However, there is a lack of sufficient scientific studies exploring the functionality, pros, and cons of hemp as a substrate for µPADs. Herein, we used a desktop pen plotter and commercial markers to pattern hydrophobic barriers on hemp paper, in a single step, in order to characterize the ability of markers to form water-resistant patterns on hemp. In addition, since a higher resolution results in densely packed, cost-effective devices with a minimized need for costly reagents, we examined the smallest and thinnest water-resistant patterns plottable on hemp-based papers. Furthermore, the wicking speed and distance of fluids with different viscosities on Whatman No. 1 and hemp papers were compared. Additionally, the wettability of hemp and Whatman grade 1 paper was compared by measuring their contact angles. Besides, the effects of various channel sizes, as well as the number of branches, on the wicking distance of the channeled hemp paper was studied. The governing equations for the wicking distance on channels with laser-cut and hydrophobic side boundaries are presented and were evaluated with our experimental data, elucidating the applicability of the modified Washburn equation for modeling the wicking distance of fluids on hemp paper-based microfluidic devices. Finally, we validated hemp paper as a substrate for the detection and analysis of the potassium concentration in artificial urine.

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19

Kong, Taejoon, Shawn Flanigan, Matthew Weinstein, Upender Kalwa, Christopher Legner, and Santosh Pandey. "A fast, reconfigurable flow switch for paper microfluidics based on selective wetting of folded paper actuator strips." Lab Chip 17, no. 21 (2017): 3621–33. http://dx.doi.org/10.1039/c7lc00620a.

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20

Islam, Md Nazibul, Jarad Yost, and Zachary Gagnon. "Electrokinetically Assisted Paper-Based DNA Concentration for Enhanced qPCR Sensing." Proceedings 60, no. 1 (2020): 33. http://dx.doi.org/10.3390/iecb2020-07074.

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Paper-based microfluidics have gained widespread attention for use as low-cost microfluidic diagnostic devices in low-resource settings. However, variability in fluid transport due to evaporation and lack of reproducibility with processing real-world samples limits their commercial potential and widespread adoption. We have developed a novel fabrication method to address these challenges. This approach, known as “Microfluidic Pressure in Paper” (μPiP), combines thin laminating polydimethylsiloxane (PDMS) membranes and precision laser-cut paper microfluidic structures to produce devices that are low-cost, scalable, and exhibit controllable and reproducible fluid flow dynamics similar to conventional microfluidic devices. We present a new μPiP DNA sample preparation and processing device that reduces the number of sample preparation steps and improves sensitivity of the quantitative polymerase chain reaction (qPCR) by electrophoretically separating and concentrating nucleic acids (NAs) continuously on paper. Our device was assembled using two different microfluidic paper channels: one with a larger pore (25 microns) size for bulk fluid transport and another with a smaller pore size (11 microns) for electrophoretic sample concentration. These two paper types were aligned and laminated within PDMS sheets, and integrated with adhesive copper tape electrodes. A solution containing a custom DNA sequence was introduced into the large pore size paper channel using a low-cost pressure system and a DC voltage was applied to the copper tape to electrophoretically deflect the solution containing NAs into the paper channel with the smaller pore size. Samples were collected from both DNA enriched and depleted channels and analyzed using qPCR. Our results demonstrate the ability to use these paper devices to process and concentrate nucleic acids. Our concentration device has the potential to reduce the number of sample preparation steps and to improve qPCR sensitivity, which has immediate applications in disease diagnostics, microbial contamination, and public health monitoring.

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21

Evard, Hanno, Hans Priks, Indrek Saar, Heili Aavola, Tarmo Tamm, and Ivo Leito. "A New Direction in Microfluidics: Printed Porous Materials." Micromachines 12, no. 6 (2021): 671. http://dx.doi.org/10.3390/mi12060671.

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In this work, the feasibility of a novel direction for microfluidics is studied by demonstrating a set of new methods to fabricate microfluidic systems. Similarly to microfluidic paper-based analytical devices, porous materials are being used. However, alternative porous materials and different printing methods are used here to give the material the necessary pattern to act as a microfluidic system. In this work, microfluidic systems were produced by the following three separate methods: (1) by curing a porous monolithic polymer sheet into a necessary pattern with photolithography, (2) by screen printing silica gel particles with gypsum, and (3) by dispensing silica gel particles with polyvinyl acetate binder using a modified 3D printer. Different parameters of the printed chips were determined (strength of the printed material, printing accuracy, printed material height, wetting characteristics, repeatability) to evaluate whether the printed chips were suitable for use in microfluidics. All three approaches were found to be suitable, and therefore the novel approach to microfluidics was successfully demonstrated.

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22

Mao, Kang, Xiaocui Min, Hua Zhang, et al. "Paper-based microfluidics for rapid diagnostics and drug delivery." Journal of Controlled Release 322 (June 2020): 187–99. http://dx.doi.org/10.1016/j.jconrel.2020.03.010.

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23

Alsaeed, Basma, and Fotouh R. Mansour. "Distance-based paper microfluidics; principle, technical aspects and applications." Microchemical Journal 155 (June 2020): 104664. http://dx.doi.org/10.1016/j.microc.2020.104664.

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24

Lei, Kin Fong, Kun-Fei Lee, and Shih-I. Yang. "Fabrication of carbon nanotube-based pH sensor for paper-based microfluidics." Microelectronic Engineering 100 (December 2012): 1–5. http://dx.doi.org/10.1016/j.mee.2012.07.113.

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25

Kurniawan, Yehezkiel Steven, Arif Cahyo Imawan, Sathuluri Ramachandra Rao, et al. "Microfluidics Era in Chemistry Field: A Review." Journal of the Indonesian Chemical Society 2, no. 1 (2019): 7. http://dx.doi.org/10.34311/jics.2019.02.1.7.

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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based and digital microfluidic devices. The brief fabrication technique of those microfluidic devices, as well as their potential application for particles separation, solvent extraction, nanoparticle fabrication, qualitative and quantitative analysis, environmental monitoring, drug delivery, biochemical assay and so on, are discussed. Recent perspectives of the microfluidics as a lab-on-chip or micro total analysis system device and organ-on-chip are also introduced.

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26

Tsur, Elishai Ezra. "Computer-Aided Design of Microfluidic Circuits." Annual Review of Biomedical Engineering 22, no. 1 (2020): 285–307. http://dx.doi.org/10.1146/annurev-bioeng-082219-033358.

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Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The field includes the development of new description languages, optimization methods, benchmarks, and integrated design tools. Here, recent advancements are reviewed in the computer-aided design of flow-, droplet-, and paper-based microfluidics. A case study of the design of resistive microfluidic networks is discussed in detail. The review concludes with perspectives on the future of computer-aided microfluidics design, including the introduction of cloud computing, machine learning, new ideation processes, and hybrid optimization.

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27

Stojanović, Paroški, Samardžić, Radovanović, and Krstić. "Microfluidics-Based Four Fundamental Electronic Circuit Elements Resistor, Inductor, Capacitor and Memristor." Electronics 8, no. 9 (2019): 960. http://dx.doi.org/10.3390/electronics8090960.

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The microfluidics domain has been progressing rapidly recently, particularly considering its useful applications in the field of biomedicine. This paper presents a novel, microfluidics-based design for four fundamental circuit elements in electronics, namely resistor, inductor, capacitor, and memristor. These widely used passive components were fabricated using a precise and cost-effective xurography technique, which enables the construction of multi-layered structures on foil, with gold used as a conductive material. To complete their assembly, an appropriate fluid was injected into the microfluidic channel of each component: the resistor, inductor, capacitor, and memristor were charged with transformer oil, ferrofluid, NaCl solution, and TiO2 solution, respectively. The electrical performance of these components was determined using an Impedance Analyzer and Keithley 2410 High-Voltage Source Meter instrument and the observed characteristics are promising for a wide range of applications in the field of microfluidic electronics.

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28

Renkó, József Bálint, Attila Bonyár, and Péter János Szabó. "Development of Microfluidic Cell for Liquid Phase Layer Deposition Tracking." Acta Materialia Transylvanica 3, no. 2 (2020): 94–97. http://dx.doi.org/10.33924/amt-2020-02-08.

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Abstract This paper shows how microfluidic tools can be used for up-to-date microstructural investigations based on thin film deposition. The construction and production methods of such measuring procedures are introduced, and their application in ellipsometric investigations is shown. By using these tools, the researchers provide the possibility to observe and document the effects of certain fine structural processes in the development of the final microstructure. This paper describes two specific application areas of such microfluidics cells. Microfluidics cells can be used together with both optical microscopy and spectroscopic ellipsometry to understand previously unexplored microstructural changes.

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29

Zhang, Lang, Jinfang Nie, Huili Wang, et al. "Instrument-free quantitative detection of alkaline phosphatase using paper-based devices." Analytical Methods 9, no. 22 (2017): 3375–79. http://dx.doi.org/10.1039/c7ay00599g.

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A new method is proposed for the quantitative detection of alkaline phosphatase (ALP) by integrating paper microfluidics with an instrument-free length-measuring readout based on the ALP-caused hydrophilicity-to-hydrophobicity change in paper.

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30

Kim, Daeyoung, Yunho Lee, Dong-Weon Lee, Wonjae Choi, Koangki Yoo, and Jeong-Bong (JB) Lee. "Hydrochloric acid-impregnated paper for gallium-based liquid metal microfluidics." Sensors and Actuators B: Chemical 207 (February 2015): 199–205. http://dx.doi.org/10.1016/j.snb.2014.09.108.

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31

Liu, Rui, Chunsun Zhang, and Min Liu. "Open bipolar electrode-electrochemiluminescence imaging sensing using paper-based microfluidics." Sensors and Actuators B: Chemical 216 (September 2015): 255–62. http://dx.doi.org/10.1016/j.snb.2015.04.014.

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32

Elizalde, Emanuel, Raúl Urteaga, and Claudio L. A. Berli. "Rational design of capillary-driven flows for paper-based microfluidics." Lab on a Chip 15, no. 10 (2015): 2173–80. http://dx.doi.org/10.1039/c4lc01487a.

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We present a tool that allows one to determine the cross-sectional profile required for a programmed liquid front velocity or flow rate during lateral imbibition in paper substrates. New regimes can be designed, i.e. constant liquid front velocity.

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33

Li, Xiao, Philip Zwanenburg, and Xinyu Liu. "Magnetic timing valves for fluid control in paper-based microfluidics." Lab on a Chip 13, no. 13 (2013): 2609. http://dx.doi.org/10.1039/c3lc00006k.

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34

Wang, Jingyun, Maria Rowena N. Monton, Xi Zhang, Carlos D. M. Filipe, Robert Pelton, and John D. Brennan. "Hydrophobic sol–gel channel patterning strategies for paper-based microfluidics." Lab Chip 14, no. 4 (2014): 691–95. http://dx.doi.org/10.1039/c3lc51313k.

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35

Davaji, Benyamin, and Chung Hoon Lee. "A paper-based calorimetric microfluidics platform for bio-chemical sensing." Biosensors and Bioelectronics 59 (September 2014): 120–26. http://dx.doi.org/10.1016/j.bios.2014.03.022.

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36

Atabakhsh, Saeed, Zahra Latifi Namin, and Shahin Jafarabadi Ashtiani. "Paper-based resistive heater with accurate closed-loop temperature control for microfluidics paper-based analytical devices." Microsystem Technologies 24, no. 9 (2018): 3915–24. http://dx.doi.org/10.1007/s00542-018-3891-5.

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Deng, B., X. F. Li, D. Y. Chen, L. D. You, J. B. Wang, and J. Chen. "Parameter Screening in Microfluidics Based Hydrodynamic Single-Cell Trapping." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/929163.

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Microfluidic cell-based arraying technology is widely used in the field of single-cell analysis. However, among developed devices, there is a compromise between cellular loading efficiencies and trapped cell densities, which deserves further analysis and optimization. To address this issue, the cell trapping efficiency of a microfluidic device with two parallel micro channels interconnected with cellular trapping sites was studied in this paper. By regulating channel inlet and outlet status, the microfluidic trapping structure can mimic key functioning units of previously reported devices. Numerical simulations were used to model this cellular trapping structure, quantifying the effects of channel on/off status and trapping structure geometries on the cellular trapping efficiency. Furthermore, the microfluidic device was fabricated based on conventional microfabrication and the cellular trapping efficiency was quantified in experiments. Experimental results showed that, besides geometry parameters, cellular travelling velocities and sizes also affected the single-cell trapping efficiency. By fine tuning parameters, more than 95% of trapping sites were taken by individual cells. This study may lay foundation in further studies of single-cell positioning in microfluidics and push forward the study of single-cell analysis.

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Hassan, Sammer-ul, and Xunli Zhang. "Microfluidics as an Emerging Platform for Tackling Antimicrobial Resistance (AMR): A Review." Current Analytical Chemistry 16, no. 1 (2020): 41–51. http://dx.doi.org/10.2174/1573411015666181224145845.

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Background: Antimicrobial resistance (AMR) occurs when microbes become resistant to antibiotics causing complications and limited treatment options. AMR is more significant where antibiotics use is excessive or abusive and the strains of bacteria become resistant to antibiotic treatments. Current technologies for bacteria and its resistant strains identification and antimicrobial susceptibility testing (AST) are mostly central-lab based in hospitals, which normally take days to weeks to get results. These tools and procedures are expensive, laborious and skills based. There is an ever-increasing demand for developing point-of-care (POC) diagnostics tools for rapid and near patient AMR testing. Microfluidics, an important and fundamental technique to develop POC devices, has been utilized to tackle AMR in healthcare. This review mainly focuses on the current development in the field of microfluidics for rapid AMR testing. Method: Due to the limitations of conventional AMR techniques, microfluidic-based platforms have been developed for better understandings of bacterial resistance, smart AST and minimum inhibitory concentration (MIC) testing tools and development of new drugs. This review aims to summarize the recent development of AST and MIC testing tools in different formats of microfluidics technology. Results: Various microfluidics devices have been developed to combat AMR. Miniaturization and integration of different tools has been attempted to produce handheld or standalone devices for rapid AMR testing using different formats of microfluidics technology such as active microfluidics, droplet microfluidics, paper microfluidics and capillary-driven microfluidics. Conclusion: Current conventional AMR detection technologies provide time-consuming, costly, labor-intensive and central lab-based solutions, limiting their applications. Microfluidics has been developed for decades and the technology has emerged as a powerful tool for POC diagnostics of antimicrobial resistance in healthcare providing, simple, robust, cost-effective and portable diagnostics. The success has been reported in research articles; however, the potential of microfluidics technology in tackling AMR has not been fully achieved in clinical settings.

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Alistar, Mirela. "Mobile Microfluidics." Bioengineering 6, no. 1 (2019): 5. http://dx.doi.org/10.3390/bioengineering6010005.

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Microfluidics platforms can program small amounts of fluids to execute a bio-protocol, and thus, can automate the work of a technician and also integrate a large part of laboratory equipment. Although most microfluidic systems have considerably reduced the size of a laboratory, they are still benchtop units, of a size comparable to a desktop computer. In this paper, we argue that achieving true mobility in microfluidics would revolutionize the domain by making laboratory services accessible during traveling or even in daily situations, such as sport and outdoor activities. We review the existing efforts to achieve mobility in microfluidics, and we discuss the conditions mobile biochips need to satisfy. In particular, we show how we adapted an existing biochip for mobile use, and we present the results when using it during a train ride. Based on these results and our systematic discussion, we identify the challenges that need to be overcome at technical, usability and social levels. In analogy to the history of computing, we make some predictions on the future of mobile biochips. In our vision, mobile biochips will disrupt how people interact with a wide range of healthcare processes, including medical testing and synthesis of on-demand medicine.

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40

Li, Xiao, and Xinyu Liu. "Microfluidics-Based Biosensors: A Microfluidic Paper-Based Origami Nanobiosensor for Label-Free, Ultrasensitive Immunoassays (Adv. Healthcare Mater. 11/2016)." Advanced Healthcare Materials 5, no. 11 (2016): 1378. http://dx.doi.org/10.1002/adhm.201670056.

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Carrilho, Emanuel, Andres W. Martinez, and George M. Whitesides. "Understanding Wax Printing: A Simple Micropatterning Process for Paper-Based Microfluidics." Analytical Chemistry 81, no. 16 (2009): 7091–95. http://dx.doi.org/10.1021/ac901071p.

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Li, Hua, and Andrew J. Steckl. "Paper Microfluidics for Point-of-Care Blood-Based Analysis and Diagnostics." Analytical Chemistry 91, no. 1 (2018): 352–71. http://dx.doi.org/10.1021/acs.analchem.8b03636.

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Gong, Max M., and David Sinton. "Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application." Chemical Reviews 117, no. 12 (2017): 8447–80. http://dx.doi.org/10.1021/acs.chemrev.7b00024.

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Carrell, Cody, Alyssa Kava, Michael Nguyen, et al. "Beyond the lateral flow assay: A review of paper-based microfluidics." Microelectronic Engineering 206 (February 2019): 45–54. http://dx.doi.org/10.1016/j.mee.2018.12.002.

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Hariharan, Abishek, Sai Manohar Chelli, Sai Muthukumar V, et al. "Paper-microfluidics based SERS substrate for PPB level detection of catechol." Optical Materials 94 (August 2019): 305–10. http://dx.doi.org/10.1016/j.optmat.2019.05.041.

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Li, Xu, David R. Ballerini, and Wei Shen. "A perspective on paper-based microfluidics: Current status and future trends." Biomicrofluidics 6, no. 1 (2012): 011301. http://dx.doi.org/10.1063/1.3687398.

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Jia, Yuan, Wenyu Wu, Jianping Zheng, Zhonghua Ni, and Hao Sun. "Spatial varying profiling of air PM constituents using paper-based microfluidics." Biomicrofluidics 13, no. 5 (2019): 054103. http://dx.doi.org/10.1063/1.5119910.

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TermehYousefi, Amin, Samira Bagheri, and Nahrizul Adib. "Integration of biosensors based on microfluidic: a review." Sensor Review 35, no. 2 (2015): 190–99. http://dx.doi.org/10.1108/sr-09-2014-697.

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Abstract:

Purpose – Biotechnology is closely associated to microfluidics. During the last decade, designs of microfluidic devices such as geometries and scales have been modified and improved according to the applications for better performance. Numerous sensor technologies existing in the industry has potential use for clinical applications. Fabrication techniques of microfluidics initially rooted from the electromechanical systems (EMS) technology. Design/methodology/approach – In this review, we emphasized on the most available manufacture approaches to fabricate microchannels, their applications and the properties which make them unique components in biological studies. Findings – Major fundamental and technological advances demonstrate the enhancing of capabilities and improving the reliability of biosensors based on microfluidic. Several researchers have been reported verity of methods to fabricate different devices based on EMS technology due to the electroconductivity properties and their small size of them. Therefore, controlled fabrication method of MEMS plays an important role to design and fabricate a highly selective detection of medical devices in a variety of biological fluids. Stable, tight and reliable monitoring devices for biological components still remains a massive challenge and several studies focused on MEMS to fabricate simple and easy monitoring devices. Originality/value – This paper is not submitted or under review in any other journal.

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Torino, Stefania, Brunella Corrado, Mario Iodice, and Giuseppe Coppola. "PDMS-Based Microfluidic Devices for Cell Culture." Inventions 3, no. 3 (2018): 65. http://dx.doi.org/10.3390/inventions3030065.

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Abstract:

Microfluidic technology has affirmed itself as a powerful tool in medical and biological research by offering the possibility of managing biological samples in tiny channels and chambers. Among the different applications, the use of microfluidics for cell cultures has attracted much interest from scientists worldwide. Traditional cell culture methods need high quantities of samples and reagents that are strongly reduced in miniaturized systems. In addition, the microenvironment is better controlled by scaling down. In this paper, we provide an overview of the aspects related to the design of a novel microfluidic culture chamber, the fabrication approach based on polydimethylsiloxane (PDMS) soft-lithography, and the most critical issues in shrinking the size of the system.

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Mabbott, Samuel, Syrena C. Fernandes, Monika Schechinger, et al. "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering." Analyst 145, no. 3 (2020): 983–91. http://dx.doi.org/10.1039/c9an01748h.

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