Relevant bibliographies by topics / Paralogues de Rad51

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Academic literature on the topic 'Paralogues de Rad51'

Author: Grafiati
Published: 7 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Paralogues de Rad51"

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Tarsounas, Madalena, Adelina A. Davies, and Stephen C. West. "RAD51 localization and activation following DNA damage." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 359, no. 1441 (2004): 87–93. http://dx.doi.org/10.1098/rstb.2003.1368.

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The efficient repair of double–strand breaks in DNA is critical for the maintenance of genome stability. In response to ionizing radiation and other DNA–damaging agents, the RAD51 protein, which is essential for homologous recombination, relocalizes within the nucleus to form distinct foci that can be visualized by microscopy and are thought to represent sites where repair reactions take place. The formation of RAD51 foci in response to DNA damage is dependent upon BRCA2 and a series of proteins known as the RAD51 paralogues (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), indicating that the compon
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Godin, Stephen K., Meghan R. Sullivan, and Kara A. Bernstein. "Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication." Biochemistry and Cell Biology 94, no. 5 (2016): 407–18. http://dx.doi.org/10.1139/bcb-2016-0012.

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In this review we focus on new insights that challenge our understanding of homologous recombination (HR) and Rad51 regulation. Recent advances using high-resolution microscopy and single molecule techniques have broadened our knowledge of Rad51 filament formation and strand invasion at double-strand break (DSB) sites and at replication forks, which are one of most physiologically relevant forms of HR from yeast to humans. Rad51 filament formation and strand invasion is regulated by many mediator proteins such as the Rad51 paralogues and the Shu complex, consisting of a Shu2/SWS1 family member
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Liu, Jie, Ludovic Renault, Xavier Veaute, Francis Fabre, Henning Stahlberg, and Wolf-Dietrich Heyer. "Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation." Nature 479, no. 7372 (2011): 245–48. http://dx.doi.org/10.1038/nature10522.

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Angelis, Karel J., Lenka Záveská Drábková, Radka Vágnerová, and Marcela Holá. "RAD51 and RAD51B Play Diverse Roles in the Repair of DNA Double Strand Breaks in Physcomitrium patens." Genes 14, no. 2 (2023): 305. http://dx.doi.org/10.3390/genes14020305.

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RAD51 is involved in finding and invading homologous DNA sequences for accurate homologous recombination (HR). Its paralogs have evolved to regulate and promote RAD51 functions. The efficient gene targeting and high HR rates are unique in plants only in the moss Physcomitrium patens (P. patens). In addition to two functionally equivalent RAD51 genes (RAD1-1 and RAD51-2), other RAD51 paralogues were also identified in P. patens. For elucidation of RAD51’s involvement during DSB repair, two knockout lines were constructed, one mutated in both RAD51 genes (Pprad51-1-2) and the second with mutated
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Khoo, Kelvin H. P., Hayley R. Jolly, and Jason A. Able. "The RAD51 gene family in bread wheat is highly conserved across eukaryotes, with RAD51A upregulated during early meiosis." Functional Plant Biology 35, no. 12 (2008): 1267. http://dx.doi.org/10.1071/fp08203.

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The RADiation sensitive protein 51 (RAD51) recombinase is a eukaryotic homologue of the bacterial Recombinase A (RecA). It is required for homologous recombination of DNA during meiosis where it plays a role in processes such as homology searching and strand invasion. RAD51 is well conserved in eukaryotes with as many as four paralogues identified in vertebrates and some higher plants. Here we report the isolation and preliminary characterisation of four RAD51 gene family members in hexaploid (bread) wheat (Triticum aestivum L.). RAD51A1, RAD51A2 and RAD51D were located on chromosome group 7,
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Pohl, Thomas J., and Jac A. Nickoloff. "Rad51-Independent Interchromosomal Double-Strand Break Repair by Gene Conversion Requires Rad52 but Not Rad55, Rad57, or Dmc1." Molecular and Cellular Biology 28, no. 3 (2007): 897–906. http://dx.doi.org/10.1128/mcb.00524-07.

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ABSTRACT Homologous recombination (HR) is critical for DNA double-strand break (DSB) repair and genome stabilization. In yeast, HR is catalyzed by the Rad51 strand transferase and its “mediators,” including the Rad52 single-strand DNA-annealing protein, two Rad51 paralogs (Rad55 and Rad57), and Rad54. A Rad51 homolog, Dmc1, is important for meiotic HR. In wild-type cells, most DSB repair results in gene conversion, a conservative HR outcome. Because Rad51 plays a central role in the homology search and strand invasion steps, DSBs either are not repaired or are repaired by nonconservative singl
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Badie, Sophie, Chunyan Liao, Maria Thanasoula, Paul Barber, Mark A. Hill, and Madalena Tarsounas. "RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation." Journal of Cell Biology 185, no. 4 (2009): 587–600. http://dx.doi.org/10.1083/jcb.200811079.

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The RAD51 paralogues act in the homologous recombination (HR) pathway of DNA repair. Human RAD51C (hRAD51C) participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Evidence for early involvement of RAD51 during DNA repair also exists, but its function in this context is not understood. In this study, we demonstrate that RAD51C accumulates at DNA damage sites concomitantly with the RAD51 recombinase and is retained after RAD51 disassembly, which is consistent with both an early and a late function fo
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Godin, Stephen, Adam Wier, Faiz Kabbinavar, et al. "The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination." Nucleic Acids Research 41, no. 8 (2013): 4525–34. http://dx.doi.org/10.1093/nar/gkt138.

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Yang, Yongjia, Jihong Guo, Lei Dai, et al. "XRCC2 mutation causes meiotic arrest, azoospermia and infertility." Journal of Medical Genetics 55, no. 9 (2018): 628–36. http://dx.doi.org/10.1136/jmedgenet-2017-105145.

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BackgroundMeiotic homologous recombination (HR) plays an essential role in gametogenesis. In most eukaryotes, meiotic HR is mediated by two recombinase systems: ubiquitous RAD51 and meiosis-specific DMC1. In the RAD51-mediated HR system, RAD51 and five RAD51 paralogues are essential for normal RAD51 function, but the role of RAD51 in human meiosis is unclear. The knockout of Rad51 or any Rad51 paralogue in mice exhibits embryonic lethality. We investigated a family with meiotic arrest, azoospermia and infertility but without other abnormalities.MethodsHomozygosity mapping and whole-exome seque
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Roy, Upasana, and Eric C. Greene. "The Role of the Rad55–Rad57 Complex in DNA Repair." Genes 12, no. 9 (2021): 1390. http://dx.doi.org/10.3390/genes12091390.

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Homologous recombination (HR) is a mechanism conserved from bacteria to humans essential for the accurate repair of DNA double-stranded breaks, and maintenance of genome integrity. In eukaryotes, the key DNA transactions in HR are catalyzed by the Rad51 recombinase, assisted by a host of regulatory factors including mediators such as Rad52 and Rad51 paralogs. Rad51 paralogs play a crucial role in regulating proper levels of HR, and mutations in the human counterparts have been associated with diseases such as cancer and Fanconi Anemia. In this review, we focus on the Saccharomyces cerevisiae R
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Dissertations / Theses on the topic "Paralogues de Rad51"

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Dupont, Chloé. "Régulation de la formation des nucléofilaments Rad51 par les complexes de paralogues de Rad51 chez la levure Saccharomyces cerevisiae." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL009.

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La recombinaison homologue (RH) est une des voies majeures de réparation des dommages de l'ADN telles que les cassures double brin (CDB). Cette voie est également impliquée dans le redémarrage des fourches de réplication bloquées à une lésion. Une étape clé de cette voie de réparation consiste en la formation de filaments nucléoprotéiques formés de la recombinase Rad51 sur de l'ADN simple brin (ADNsb). Ces nucléofilaments sont responsables de la recherche d'homologie et de l'invasion d'un ADN intact et semblable à l'ADN endommagé afin de l'utiliser comme matrice pour la synthèse réparatrice. L
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Dobson, Rachel Pamela. "Analysis of the functions and interactions of RAD51 paralogues in Trypanosoma brucei." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/939/.

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Trypanosoma brucei evades host acquired immunity by antigenic variation, involving periodic switches in the variant surface glycoprotein (VSG) coat. DNA recombination is critical in this process and a key component of homologous recombination, RAD51, also plays a role in VSG switching. T. brucei encodes four proteins distantly related to RAD51; termed RAD51 paralogues, named RAD51-3, RAD51-4, RAD51-5 and RAD51-6. Two of these RAD51 paralogues, RAD51-3 and RAD51-5, have been shown to function in homologous recombination, DNA repair and RAD51 re-localization into foci following DNA damage. Surpr
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Rodrigue, Amélie. "Rôles des paralogues de RAD51 humains dans la recombinaison homologue et le maintien de la stabilité du génome en mitose." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/27916/27916.pdf.

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Daboussi, Fayza. "Relations épistatiques entre RAD51 et ses paralogues chez les mammifères : étude de la sensibilité aux stress génotoxiques, la recombinaison homologue, la duplication des centrosomes et la réplication." Paris 7, 2005. http://www.theses.fr/2005PA077199.

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La recombinaison homologue (RH) est un processus fondamental conservé chez les tous les organismes vivants. Chez les mammifères, ce processus implique de nombreuses protéines parmi lesquelles Rad51 et ses paralogues. Afin de déterminer si ces paralogues agissent dans la même voie que RAD51, nous avons réalisé une étude d'épistasie en associant la sur-expression d'un dominant négatif de RAD51 avec une mutation dans un des paralogues, le gène XRCC2. Cette étude montre que les protéines Xrcc2 et Rad51 sont impliquées dans la même voie pour la résistance aux stress génotoxiques, la recombinaison h
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Oliveira, Ana Clara. "Influência do gene PTEN na expressão de RAD51 e suas parálogas, RAD51C e RAD51B, em linhagens de glioblastoma multiforme tratadas com etoposídeo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-27072016-143803/.

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O Glioblastoma Multiforme (GBM) é o tipo de tumor cerebral maligno com maior incidência na população. A perda do gene PTEN (fosfatase e tensina homóloga) é uma alteração comum associada ao GBM (até 60%) e esse gene codifica uma enzima que antagoniza a ação de PI3K, inibindo a fosforilação de AKT e, desse modo, regulando vias de sinalização relativas à sobrevivência celular e proliferação. Mutações em PTEN têm sido associadas à instabilidade genômica e ao aumento no número de quebras de fita dupla, além de serem relacionadas também à redução da expressão de RAD51, a qual é uma proteína-chave da
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Taylor, M. R. G. "Mechanism of action of Rad51 paralogs." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1458671/.

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Homologous recombination (HR) is an essential DNA break repair mechanism that remains incompletely understood. HR is a complex multistep process initiated by the loading of RAD-51 recombinase as filaments onto single stranded DNA (ssDNA). This structure directly invades an intact homologous duplex, which serves as a template for repair DNA synthesis. Numerous positive regulators of HR have been described, including the Rad51 paralogs, but the mechanism of action of Rad51 paralogs in promoting HR is unknown. In this study, I have characterized the mechanism of action of a novel Rad51 paralog co
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Van, Laar Tricia A. "The behavior of RAD51D and XRCC2 in response to drug induced DNA damage and a continuing study of the fly RAD51 paralogs." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/764.

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Repair of DNA damage is one of the most important processes undergone in a dividing cell. This is a two-part study undertaken to better understand some of the proteins involved in the sensing and repair of DNA damage in Drosophila melanogaster. The first portion of this experiment followed two Drosophila Rad51 paralogs, dmRad51D and dmXRRC2, and using constructs tagged with GFP, found that they entered the nucleus in response to drug induced DNA damage. Approximately one hour after the induction of DNA damage via bleomycin, dmRad51D and dmXRCC2 entered the nucleus of the Drosophila culture cel
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Haldenby, Sam. "Genetic analysis of RadB, a paralogue of the archaeal Rad51/RecA homologue, RadA." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/10384/.

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The integrity of all genomes is under constant threat, with DNA double strand breaks being particularly dangerous. Double strand breaks can be repaired by homologous recombination, a process catalysed by recombinase proteins of the RecA family. The archaeal recombinase, RadA, is homologous to eukaryotic and bacterial Rad51/RecA. Euryarchaea encode an additional Rad51/RecA homologue, RadB. RadB shares homology with the core domain of RadA and has been shown to bind both single and double stranded DNA, binds ATP and possesses a very weak ATPase activity. However, RadB does not catalyse strand ex
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Amunugama, Ravindra Bandara. "Insights into Regulation of Human RAD51 Nucleoprotein Filament Activity During Homologous Recombination." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1321984760.

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Saini, Siddharth. "Role of XRCC3 in Acquisition and Maintenance of Invasiveness through Extracellular Matrix in Breast Cancer Progression." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/131.

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Acquisition of invasiveness through extracellular matrix is a crucial characteristic of transition to malignancy in the breast. It was previously shown that Polo-like kinase 1 (PLK-1), a mitotic kinase and genome stability regulator, is involved in acquisition of invasiveness in a breast cell model (HMT-3522 cell line) of pre-invasive to invasive transition. This and other data led to the suggestion that a new class of genes called GISEM for Genome Instability and Extracellular Matrix Invasiveness may exist. Previous lab data show that XRCC3 is found downregulated in progression from prei
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Book chapters on the topic "Paralogues de Rad51"

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Roy, Upasana, Youngho Kwon, Patrick Sung, and Eric C. Greene. "Single-molecule studies of yeast Rad51 paralogs." In Methods in Enzymology. Elsevier, 2021. http://dx.doi.org/10.1016/bs.mie.2021.08.006.

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