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Journal articles on the topic 'Paraneoplastic neurological syndromes'

Author: Grafiati

Published: 21 December 2024

Last updated: 25 July 2025

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1

Pathirana, KD. "Paraneoplastic neurological syndromes." Ceylon Medical Journal 53, no. 4 (2009): 148. http://dx.doi.org/10.4038/cmj.v53i4.290.

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2

Chad, David A., and Lawrence D. Recht. "Neurological Paraneoplastic Syndromes." Cancer Investigation 6, no. 1 (1988): 67–82. http://dx.doi.org/10.3109/07357908809077030.

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3

Bashir, R., and F. Hochberg. "Paraneoplastic Neurological Syndromes." Cancer Investigation 6, no. 1 (1988): 117–18. http://dx.doi.org/10.3109/07357908809077035.

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4

Nath, U., and R. Grant. "Neurological paraneoplastic syndromes." Journal of Clinical Pathology 50, no. 12 (1997): 975–80. http://dx.doi.org/10.1136/jcp.50.12.975.

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5

Sutton, Ian. "Paraneoplastic neurological syndromes." Current Opinion in Neurology 15, no. 6 (2002): 685–90. http://dx.doi.org/10.1097/00019052-200212000-00005.

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6

Sutton, Ian. "Paraneoplastic neurological syndromes." Current Opinion in Neurology 15, no. 6 (2002): 685–90. http://dx.doi.org/10.1097/01.wco.0000044764.39452.64.

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7

Leypoldt, F., and K. P. Wandinger. "Paraneoplastic neurological syndromes." Clinical & Experimental Immunology 175, no. 3 (2014): 336–48. http://dx.doi.org/10.1111/cei.12185.

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8

Dalmau, Josep O., and Jerome B. Posner. "Neurological Paraneoplastic Syndromes." Neuroscientist 4, no. 6 (1998): 443–53. http://dx.doi.org/10.1177/107385849800400616.

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9

Smitt, Peter Sillevis. "Paraneoplastic neurological syndromes." Lancet Neurology 1, no. 7 (2002): 408. http://dx.doi.org/10.1016/s1474-4422(02)00218-1.

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10

Graus, Francesc, and Josep Dalmau. "Paraneoplastic neurological syndromes." Current Opinion in Neurology 25, no. 6 (2012): 795–801. http://dx.doi.org/10.1097/wco.0b013e328359da15.

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11

Toothaker, Thomas B., and Michael Rubin. "Paraneoplastic Neurological Syndromes." Neurologist 15, no. 1 (2009): 21–33. http://dx.doi.org/10.1097/nrl.0b013e3181870aa2.

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12

Iorio, Raffaele, Gregorio Spagni, and Gianvito Masi. "Paraneoplastic neurological syndromes." Seminars in Diagnostic Pathology 36, no. 4 (2019): 279–92. http://dx.doi.org/10.1053/j.semdp.2019.06.005.

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13

Dalmau, Josep, and Jerome B. Posner. "Neurological paraneoplastic syndromes." Springer Seminars in Immunopathology 18, no. 1 (1996): 85–95. http://dx.doi.org/10.1007/bf00792611.

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14

Fathallah-Shaykh, Hassan M. "Paraneoplastic Neurological Syndromes." Archives of Neurology 56, no. 2 (1999): 151. http://dx.doi.org/10.1001/archneur.56.2.151.

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15

Devine, Michelle F., Naga Kothapalli, Mahmoud Elkhooly, and Divyanshu Dubey. "Paraneoplastic neurological syndromes: clinical presentations and management." Therapeutic Advances in Neurological Disorders 14 (January 2021): 175628642098532. http://dx.doi.org/10.1177/1756286420985323.

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We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We pr

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16

Erraichi, Hayat, Niaina Ezra Randriamanovontsoa, Valère Litique, et al. "Ovarian Cancer Revealed by Paraneoplastic Cerebellar Degeneration Anti-Yo Positive: A Case Report." International Journal of Innovative Research in Medical Science 5, no. 12 (2020): 635–37. http://dx.doi.org/10.23958/ijirms/vol05-i12/1016.

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Neurological paraneoplastic syndromes are rare, often associated with gynecological cancer or small cell lung cancer. This article reports a case of ovarian cancer to discuss the difficulties in the management of neurological paraneoplastic syndromes. This is a case of paraneoplastic cerebellar syndrome with anti-Yo antibodies. Neurological syndromes, testing for onconeural antibodies and testing for underlying cancer provide a basis for the diagnosis. The anti-tumor treatment constitutes the mainstay of the care.

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17

Joy, Shiny, Ayush Agarwal, Shamim Ahmed Shamim, and Ajay Garg. "Seronegative paraneoplastic encephalomyelitis in occult colonic carcinoma." BMJ Case Reports 16, no. 9 (2023): e254397. http://dx.doi.org/10.1136/bcr-2022-254397.

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Paraneoplastic neurological syndromes are immune-mediated neurological attacks triggered by malignancies. They are commonly associated with lung, breast, thymus, gynaecological and haematological malignancies. We report a case of a male patient in his late 40s with paraneoplastic encephalomyelitis due to a colonic adenocarcinoma emphasising a low threshold for extensive cancer evaluation in all subacutely presenting neurological syndromes. We also emphasise that the absence of a positive onconeural antibody does not preclude the diagnosis of a paraneoplastic syndrome.

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18

Pranzatelli, M. R. "Peripheral neurological paraneoplastic syndromes." Drugs of Today 34, no. 7 (1998): 625. http://dx.doi.org/10.1358/dot.1998.34.7.485261.

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19

Lorusso, Lorenzo, Ian K. Hart, Daniela Ferrari, Gaelle K. Ngonga, Chiara Gasparetto, and Giovanni Ricevuti. "Autonomic paraneoplastic neurological syndromes." Autoimmunity Reviews 6, no. 3 (2007): 162–68. http://dx.doi.org/10.1016/j.autrev.2006.10.003.

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20

Yang, Ingrid, Joanna Jaros, and Danny Bega. "Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature." Case Reports in Neurology 9, no. 1 (2017): 22–30. http://dx.doi.org/10.1159/000458435.

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Neurologic symptoms secondary to a paraneoplastic syndrome may be the presenting manifestation of a previously undiagnosed cancer, and alertness to these syndromes may provide an opportunity for early detection and treatment of a cancer. Paraneoplastic weakness is a rare manifestation of renal cell carcinoma and may present with variable electrophysiological features. We present a case of a patient with progressive weakness, sensory changes, and urinary retention, with electrophysiological features suggestive of a complex peripheral nervous system syndrome. Ultimately, a renal cell mass was de

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21

Avino, Gianluca, Fabiola De Marchi, Roberto Cantello, and Letizia Mazzini. "Anti-Yo Paraneoplastic Cerebellar Degeneration and Breast Cancer: A Long Survival of Persistent Cerebellar Syndrome." Sclerosis 1, no. 1 (2022): 5–8. http://dx.doi.org/10.3390/sclerosis1010002.

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Paraneoplastic neurological syndromes (PNS) occur in 1–3% of all cancer patients with several cancer-related neurologic diseases involving any part of the nervous system. Paraneoplastic cerebellar degeneration (PCD) is a specific type of PNS characterized by sub-acute cerebellar syndrome with trunk and limb ataxia, dysarthria, diplopia, and vertigo. We report herein the case of a 70-year-old female patient with cerebellar symptoms and transient anti-Yo antibody PCD positivity manifested three years after a breast cancer diagnosis who is currently neurologically stable after an extended follow-

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22

Kamimura, Hiroteru, Tomohiro Iwasaki, Kazunao Hayashi, and Shuji Terai. "Rare paraneoplastic syndromes in digestive systems caused by lung cancer." BMJ Case Reports 14, no. 2 (2021): e240161. http://dx.doi.org/10.1136/bcr-2020-240161.

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We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer’s syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestin

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23

Chakravarthy, Krishnan. "Updated Review and Treatment Recommendations on Paraneoplastic Neurologic Syndromes and Chronic Pain." Pain Physician 5, no. 22;5 (2019): 433–45. http://dx.doi.org/10.36076/ppj/2019.22.433.

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Background: This comprehensive review of pain in paraneoplastic neurological syndromes focuses on current mechanisms that lead to pain, including autoimmune processes as well as the systemic secretion of factors that sensitize nociceptive nerves. Systemic secretion of functional molecules is a well-recognized phenomenon in endocrine paraneoplastic syndromes; however, cancer pain research has predominantly focused on cytokine-nerve interactions in the tumor microenvironment, and few groups have applied the molecular mechanisms of local pain to study widespread neuropathic pain resulting from sy

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24

Höftberger, Romana, Myrna R. Rosenfeld, and Josep Dalmau. "Update on neurological paraneoplastic syndromes." Current Opinion in Oncology 27, no. 6 (2015): 489–95. http://dx.doi.org/10.1097/cco.0000000000000222.

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25

Didelot, Adrien, and Jérôme Honnorat. "Update on paraneoplastic neurological syndromes." Current Opinion in Oncology 21, no. 6 (2009): 566–72. http://dx.doi.org/10.1097/cco.0b013e3283306647.

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26

Honnorat, Jérôme, and Stéphanie Cartalat-Carel. "Advances in paraneoplastic neurological syndromes." Current Opinion in Oncology 16, no. 6 (2004): 614–20. http://dx.doi.org/10.1097/01.cco.0000142486.89472.eb.

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27

Voltz, Raymond. "Paraneoplastic neurological syndromes – Author's reply." Lancet Neurology 1, no. 7 (2002): 408. http://dx.doi.org/10.1016/s1474-4422(02)00219-3.

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28

Vedeler, C. "240 INVITED Paraneoplastic Neurological Syndromes." European Journal of Cancer 47 (September 2011): S57. http://dx.doi.org/10.1016/s0959-8049(11)70455-5.

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29

Giannopoulou, Chariklia. "Navigating the paraneoplastic neurological syndromes." European Journal of Nuclear Medicine and Molecular Imaging 30, no. 3 (2003): 333–38. http://dx.doi.org/10.1007/s00259-002-1005-0.

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30

Giometto, B., B. Taraloto, and F. Graus. "Autoimmunity in Paraneoplastic Neurological Syndromes." Brain Pathology 9, no. 2 (2006): 261–73. http://dx.doi.org/10.1111/j.1750-3639.1999.tb00225.x.

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31

Zoccarato, Marco, Matteo Gastaldi, Luigi Zuliani, et al. "Diagnostics of paraneoplastic neurological syndromes." Neurological Sciences 38, S2 (2017): 237–42. http://dx.doi.org/10.1007/s10072-017-3031-5.

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32

Opalińska, Marta, Anna Sowa-Staszczak, Kamil Wężyk, Jeremiasz Jagiełła, Agnieszka Słowik, and Alicja Hubalewska-Dydejczyk. "Additional Value of [18F]FDG PET/CT in Detection of Suspected Malignancy in Patients with Paraneoplastic Neurological Syndromes Having Negative Results of Conventional Radiological Imaging." Journal of Clinical Medicine 11, no. 6 (2022): 1537. http://dx.doi.org/10.3390/jcm11061537.

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Background: Paraneoplastic neurological syndromes (PNS) affecting the CNS (central nervous system) are rare, presenting in less than 1% of all those with cancer. The pathogenesis of paraneoplastic neurological syndromes is not fully understood, but it is presumed to result from an immune attack on the underlying malignancy. The presence of different types of onconeural antibodies may occur in different tumors and can lead to different clinical manifestations, making the early detection of cancers challenging. Aim: An evaluation of [18F]FDG PET/CT in neoplastic tumor detection in patients with

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33

Naqvi, Syed Mohammad, Hashim Talib Hashim, Syed Yaseen Naqvi, et al. "Small cell lung cancer progressing into fatal ascending motor and sensory polyneuropathy despite dramatic response to chemotherapy: A case report." Medicine 104, no. 1 (2025): e41172. https://doi.org/10.1097/md.0000000000041172.

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Rationale: Paraneoplastic syndromes occur in 10% to 20% of all malignancies, with paraneoplastic neurological syndromes in less than 1% of all malignancies. In small cell lung cancer (SCLC), paraneoplastic manifestations are more common, affecting up to 5% of cases. Common manifestations include syndrome of inappropriate antidiuretic hormone secretion, Cushing’s syndrome due to adrenocorticotropic hormone secretion, paraneoplastic cerebellar degeneration, and Lambert-Eaton myasthenic syndrome. Paraneoplastic acute motor and sensory polyneuropathy is an exceptionally rare but severe complicatio

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34

Rajan, Archana, and Abhisek Sahoo. "Paraneoplastic Syndromes in Small Cell Lung Cancer: A Narrative Review." International Journal of Research and Review 10, no. 7 (2023): 660–70. http://dx.doi.org/10.52403/ijrr.20230778.

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Paraneoplastic syndromes are commonly associated with lung cancer, particularly small-cell lung cancer. These syndromes often occur before the cancer is diagnosed or in the early stages of the disease. However, they can also occur at the time of metastasis. Through this article, we want to focus on the epidemiology, pathophysiology, symptoms, and current treatment approaches for the most frequent paraneoplastic syndromes seen in patients with small-cell lung cancer. Recent advancements have improved our understanding of these syndromes and provided better diagnostic and therapeutic options. Be

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35

Rudnicka, Halina, Agnieszka I. Jagiello Gruszfeld, and Iwona Glogowska. "Antigens diagnoses in paraneoplastic neurological syndromes." Journal of Clinical Oncology 30, no. 15_suppl (2012): 10582. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10582.

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10582 Background: At present, paraneoplasmatic neurological syndroms (PNS) are thought to be autoimmunological disorders. Neurological symptoms in PNS result from the disturbance of the nervous system, with a participation of the immune response triggered by the aberrant expression of the so-called onconeuronal antigens of a tumour. Very important for PNS diagnostics is the investigation of antineuronal antibodies (ANA) in the serum. Different types of ANA are frequently associated with specific tumors and with specific neurological syndromes.Investigations of serum ANA in patients with breast

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36

Grigoryeva, V. N., and E. A. Ruina. "Paraneoplastic neurological syndromes: upgraded approaches to diagnosis." Russian neurological journal 29, no. 1 (2024): 4–13. http://dx.doi.org/10.30629/2658-7947-2024-29-1-4-13.

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Paraneoplastic neurological syndromes (PNNS) are neurological disorders due to autoimmune attack on the nervous system, induced by a tumor remote from these structures. The existence of relatively stable associations between the neurological syndrome, the type of antineuronal antibodies (Ab) and the nature of tumor has been proven. At the same time, there are no pathognomonic combinations of this kind: the same antibodies can be detected in diff erent types of tumors and in diff erent syndromes. In addition, level of reliability of the diagnosis of PNNS is considered, taking into account the p

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37

Dai, Yi-Ling, Ling Xiao, Zhen Pan, et al. "Anti-Hu antibody associated paraneoplastic neurological syndrome in a child with ganglioneuroblastoma: A rare case report and literature review." Medicine 103, no. 19 (2024): e38148. http://dx.doi.org/10.1097/md.0000000000038148.

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Rationale: Paraneoplastic neurological syndrome with anti-Hu antibody (Hu-PNS) is a neurological disorder that occur in patients with malignancy. The syndrome has a wide range of presentations and can present before diagnosis of primary malignancy. Familiarity with these paraneoplastic neurological syndromes can help early recognition and take appropriate regimens. Patients concerns: Diagnosis and treatment of Hu-PNS. Diagnoses: This is retrospective study that analyzed the clinical data of this case. Through retrospective analysis and targeted antibody screening, serum anti-Hu antibody was de

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38

Samaha, Shehab, and Andrew J. Larner. "Cerebellar syndrome: cause cured, but symptoms persist." Progress in Neurology and Psychiatry 27, no. 4 (2023): 27–29. http://dx.doi.org/10.1002/pnp.812.

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Subacute cerebellar syndromes have a broad differential diagnosis, which includes paraneoplasia. Paraneoplastic cerebellar degeneration needs to be considered in this clinical situation even if initial brain imaging is normal, and the neurological prognosis is guarded even if the underlying tumour can be successfully treated.

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39

Deleva, Nadezhda. "Neurological paraneoplastic syndromes in education and neurological practice." Scripta Scientifica Medica 39, no. 2 (2007): 155. http://dx.doi.org/10.14748/ssm.v39i2.489.

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40

SUTTON, Ian, and John B. WINER. "The immunopathogenesis of paraneoplastic neurological syndromes." Clinical Science 102, no. 5 (2002): 475–86. http://dx.doi.org/10.1042/cs1020475.

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Paraneoplastic neurological syndromes are rare non-metastatic complications of cancer that have an immune-mediated aetiology. The central and peripheral nervous systems are considered to be immune-privileged sites, since the presence of the ‘blood-brain/nerve barrier’ means that antigens sequestered within the nervous system do not normally induce an immune response. Aberrant expression of a neuronal antigen by a tumour arising outside this barrier can lead to the breakdown of immune tolerance to the nervous system. However, in many cases the immune mechanisms that result in neurological dysfu

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41

Małek, Natalia, Sara Emerla, Aleksandra Brożyna, et al. "Paraneoplastic syndromes in childhood neuroblastoma." Journal of Education, Health and Sport 71 (May 24, 2024): 51252. http://dx.doi.org/10.12775/jehs.2024.71.51252.

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INTRODUCTION: Neuroblastoma is a malignant tumor primarily affecting infants. Originating from embryonic cells of the sympathetic nervous system, NB commonly arises in the adrenal glands, followed by the abdomen, mediastinum, head, and neck. Clinical presentation varies depending on the tumor's location. General symptoms, if present, include fatigue, weight loss, and fever. The paraneoplastic syndrome refers to symptoms and disorders associated with malignant tumors but not directly caused by the tumor itself or its metastases. Opsoclonus-myoclonus syndrome and diarrhea are the most common par

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42

Tanaka, Keiko. "Diagnostic Significance of Paraneoplastic Neurological Syndromes." Nihon Naika Gakkai Zasshi 97, no. 8 (2008): 1761–63. http://dx.doi.org/10.2169/naika.97.1761.

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43

Nomura, Kyoichi. "2. Immunotherapy for Paraneoplastic Neurological Syndromes." Nihon Naika Gakkai Zasshi 97, no. 8 (2008): 1830–37. http://dx.doi.org/10.2169/naika.97.1830.

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44

Hansra, Damien, and Stefan Glück. "Paraneoplastic neurological syndromes in breast cancer." Breast Cancer Management 3, no. 1 (2014): 113–20. http://dx.doi.org/10.2217/bmt.13.65.

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45

Symonds, R. P., R. B. Hogg, and I. Bone. "Paraneoplastic Neurological Syndromes Associated with Lymphomas." Leukemia & Lymphoma 15, no. 5-6 (1994): 487–90. http://dx.doi.org/10.3109/10428199409049752.

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46

SUTTON, Ian, and John B. WINER. "The immunopathogenesis of paraneoplastic neurological syndromes." Clinical Science 102, no. 5 (2002): 475. http://dx.doi.org/10.1042/cs20010121.

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47

Lorusso, L., I. K. Hart, B. Giometto, et al. "Immunological Features of Paraneoplastic Neurological Syndromes." International Journal of Immunopathology and Pharmacology 17, no. 2 (2004): 135–44. http://dx.doi.org/10.1177/039463200401700205.

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48

Graus, Francesc, and Josep Dalmau. "Paraneoplastic neurological syndromes: diagnosis and treatment." Current Opinion in Internal Medicine 7, no. 1 (2008): 82–87. http://dx.doi.org/10.1097/wco.0b013e3282f189dc.

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49

Honnorat, J., and A. Viaccoz. "New concepts in paraneoplastic neurological syndromes." Revue Neurologique 167, no. 10 (2011): 729–36. http://dx.doi.org/10.1016/j.neurol.2011.08.001.

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50

Joubert, Bastien, and Jérôme Honnorat. "Autoimmune channelopathies in paraneoplastic neurological syndromes." Biochimica et Biophysica Acta (BBA) - Biomembranes 1848, no. 10 (2015): 2665–76. http://dx.doi.org/10.1016/j.bbamem.2015.04.003.

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