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Relevant bibliographies by topics / Paraproteins

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Academic literature on the topic 'Paraproteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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Journal articles on the topic "Paraproteins"

1

Grass, Sandra, Klaus-Dieter Preuss, Stephan Thome, et al. "Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM." Blood 118, no. 3 (2011): 635–37. http://dx.doi.org/10.1182/blood-2011-01-331454.

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Abstract Paratarg-7 (P-7) is a frequent paraprotein target in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), and Waldenström macroglobulinemia. Patients with P-7-specific paraproteins carry a hyperphosphorylated paratarg-7 (pP-7). Because pP-7 carrier state is dominantly inherited, we determined the paraprotein targets in 4 families with familial MGUS/MM. No antigenic target was identified for the paraproteins from 2 members of one family. Paraproteins from affected members of 2 other families targeted P-7, and paraproteins from 4 affected members of a fourth

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Henskens, Yvonne, John de Winter, Maurits Pekelharing, and Gabrielle Ponjee. "Detection and identification of monoclonal gammopathies by capillary electrophoresis." Clinical Chemistry 44, no. 6 (1998): 1184–90. http://dx.doi.org/10.1093/clinchem/44.6.1184.

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Abstract Capillary electrophoresis (CE) and immunosubtraction capillary electrophoresis (IS-CE) were compared with the conventional methods agarose gel electrophoresis (AGE) and immunofixation electrophoresis (IFE) for detection and identification of paraproteins. In total, 74 paraproteins out of 468 serum samples were detected by both methods. Seventy-three monoclonal bands with concentrations ranging from 0.6 to 50.9 g/L were detected by the routine method. With CE, 70 paraproteins were detected and quantified on the electropherogram. Four paraproteins were not detected by CE; three of these

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3

Bowles, Shirley A., R. Campbell Tait, Stephen G. Jefferson, Maria H. Gilleece, and Mansel R. Haeney. "Characteristics of Monoclonal Immunoglobulins That Interfere with Serum Inorganic Phosphate Measurement." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 31, no. 3 (1994): 249–54. http://dx.doi.org/10.1177/000456329403100306.

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The measurement of inorganic phosphate using an unmodified acid/molybdate assay is known to be subject to interference when paraproteinaemia exists. This phenomenon, due to precipitation in the reaction mixture, is not common to all paraproteins. We studied sera from 35 patients to determine whether interference in the assay was related to particular electrophysical characteristics of the paraproteins. There were spuriously elevated phosphate concentrations in 48·6% of the sera assayed. This could not be related to a direct effect of light chain type, electrical charge or IgG subclass. No IgA

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Carney, Dennis A., Srinivas R. Mummadi, Susan A. Lerner, and Michael J. Keating. "Paraproteins in CLL Are Frequently the Product of Another Clone." Blood 104, no. 11 (2004): 1912. http://dx.doi.org/10.1182/blood.v104.11.1912.1912.

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Abstract Paraproteins are found in 5–10% of CLL patients using conventional techniques and in a higher number using more sensitive techniques. The significance of this finding is uncertain although it has been suggested to be associated with a worse prognosis. When a paraprotein occurs with CLL it is usually considered to be a product of the leukemic clone. However there is an increased incidence of both B cell clonal expansions and monoclonal immunoglobulins (Igs) in the elderly suggesting an alternative source may exist. We examined the clinicopathological features of 34 cases of paraprotein

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5

Klouche, M., A. R. Bradwell, D. Wilhelm, and H. Kirchner. "Subclass typing of IgG paraproteins by immunofixation electrophoresis." Clinical Chemistry 41, no. 10 (1995): 1475–79. http://dx.doi.org/10.1093/clinchem/41.10.1475.

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Abstract We present a simple method for subclass typing of IgG paraproteins, with which we have demonstrated a large number of paraproteins that were undetected by conventional immunofixation techniques. The types and distribution of IgG subclass paraproteins were analyzed in 92 human sera in which IgG paraproteins had been demonstrated. The IgG subclass paraproteins were separated by agarose gel electrophoresis rapidly and simply and then typed with the use of sheep anti-human monospecific IgG1-IgG4 antibodies. In 24 of the sera analyzed, IgG subclass typing revealed 25 additional monoclonal

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6

Berenson, JR, A. Lichtenstein, S. Hart, D. Palomares, and RA Miller. "Expression of shared idiotypes by paraproteins from patients with multiple myeloma and monoclonal gammopathy of undetermined significance." Blood 75, no. 11 (1990): 2107–11. http://dx.doi.org/10.1182/blood.v75.11.2107.2107.

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Abstract Twenty-nine murine monoclonal antibodies have been produced that react with shared idiotypes expressed by B-cell lymphomas and leukemias. We tested this panel of antibodies for reactivity with the paraproteins from 32 patients with multiple myeloma and 10 patients with monoclonal gammopathy of undetermined significance (MGUS). Thirteen of 42 paraproteins reacted with at least one antibody in this panel of anti- idiotypic antibodies. Six different anti-idiotypes demonstrated reactivity with the paraproteins. A similar frequency of reactivity was found for both myeloma and MGUS proteins

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Berenson, JR, A. Lichtenstein, S. Hart, D. Palomares, and RA Miller. "Expression of shared idiotypes by paraproteins from patients with multiple myeloma and monoclonal gammopathy of undetermined significance." Blood 75, no. 11 (1990): 2107–11. http://dx.doi.org/10.1182/blood.v75.11.2107.bloodjournal75112107.

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Twenty-nine murine monoclonal antibodies have been produced that react with shared idiotypes expressed by B-cell lymphomas and leukemias. We tested this panel of antibodies for reactivity with the paraproteins from 32 patients with multiple myeloma and 10 patients with monoclonal gammopathy of undetermined significance (MGUS). Thirteen of 42 paraproteins reacted with at least one antibody in this panel of anti- idiotypic antibodies. Six different anti-idiotypes demonstrated reactivity with the paraproteins. A similar frequency of reactivity was found for both myeloma and MGUS proteins. One ant

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8

Norden, A. G., L. M. Fulcher, and A. D. Heys. "Rapid typing of serum paraproteins by immunoblotting without antigen-excess artifacts." Clinical Chemistry 33, no. 8 (1987): 1433–36. http://dx.doi.org/10.1093/clinchem/33.8.1433.

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Abstract In this new immunoblotting procedure for determining the heavy-chain class and light-chain type of monoclonal serum immunoglobulins, proteins are transferred from agarose electrophoretic gels to nitrocellulose by brief capillary blotting. Paraproteins transferred are detected with appropriate horseradish peroxidase-conjugated antisera to light chain and heavy chain. Examination of 121 serum specimens probably containing a paraprotein (as detected by protein staining) by immunoblotting and by immunofixation gave the same results for 116 specimens: paraproteins were typed in 103 specime

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9

Preuss, Klaus-Dieter, Michael Pfreundschuh, Natalie Fadle, et al. "Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A." Blood 118, no. 12 (2011): 3340–46. http://dx.doi.org/10.1182/blood-2011-04-351668.

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Abstract Paratarg-7, a frequent autoantigenic target, and all other autoantigenic targets of human paraproteins molecularly defined to date are hyperphosphorylated in the respective patients compared with healthy controls, suggesting that hyperphosphorylation of autoantigenic paraprotein targets is a general mechanism underlying the pathogenesis of these paraproteins. We now show that hyperphosphorylation of paratarg-7 occurs because of an additional phosphorylation of Ser17, which is located within the paraprotein-binding epitope. Coimmunoprecipitation identified phosphokinase C ζ (PKCζ) as t

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Ng, VL, KH Chen, KM Hwang, H. Khayam-Bashi, and MS McGrath. "The clinical significance of human immunodeficiency virus type 1- associated paraproteins." Blood 74, no. 7 (1989): 2471–75. http://dx.doi.org/10.1182/blood.v74.7.2471.2471.

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Abstract We observed and characterized paraproteins present in the serum of seven human immunodeficiency virus type 1 (HIV-1)-infected individuals. Immunoglobulin (Ig) subclass typing performed on these paraproteins identified five as IgG1 kappa, one as an IgG3 lambda, and one as an IgA lambda. The IgG1 kappa paraproteins, purified by high-pressure liquid chromatography, contained the majority of anti-HIV-1 antibody reactivity present in the five serum specimens (ranging from 1:5,000 to 1:500,000) as demonstrated by immunoblot. All five IgG1 paraproteins had at least two light chain species as

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Dissertations / Theses on the topic "Paraproteins"

1

Ayoub, Fayad Mazen. "The interactions of paraproteins and albumin with artificial and biological membranes." Thesis, University of Essex, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295643.

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2

Ramadan, Gamal Ramadan Shebl. "Induction of in vitro T cell immune response against the variable region of paraprotein light chain through autologous dendritic cells." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963906038.

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Ciesiolka, Aleksandra [Verfasser], and Michael [Akademischer Betreuer] Pfreundschuh. "Hyperphosphoryliertes Paratarg-7 als molekulare Zielstruktur von Paraproteinen bei Patienten mit MGUS, Multiplen Myelom und Makroglobulinämie Waldenström / Aleksandra Ciesiolka. Betreuer: Michael Pfreundschuh." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1064868576/34.

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Lachira-Yparraguirre, Lizbeth, Ali Al-kassab-Córdova, Edgar Quispe-Silvestre, and Daniel Enriquez-Vera. "Cardiac amyloidosis secondary to waldenström macroglobulinemia." Editorial Ciencias Medicas, 2020. http://hdl.handle.net/10757/655705.

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Introduction: Waldenström's macroglobulinemia is a hematological neoplasm belonging to the group of monoclonal gammopathies, which includes systemic symptoms and those related to an increase in M paraprotein. Objective: To describe a case of cardiac amyloidosis associated with macroglobulinemia. Clinical case: Male patient who was admitted for asthenia, dysphonia, and who, during his evolution, developed progressive dyspnea, heart failure and pleural effusion. Additionally, echocardiography showed myocardial granular pattern, while pleural biopsy was positive for Congo red staining. Subsequent

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Ramadan, Gamal Ramadan Shebl [Verfasser]. "Induction of in vitro T cell immune response against the variable region of paraprotein light chain through autologous dendritic cells / Gamal Ramadan Shebl Ramadan." 2001. http://d-nb.info/963906038/34.

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Books on the topic "Paraproteins"

1

W, Pruzanski, and Keystone E. C, eds. Paraproteins in disease: Investigation of plasma cell dyscrasia. Churchill Livingstone, 1985.

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2

W, Pruzanski, and Keystone E. C, eds. Paraproteins in desease: Investigation of plasma cell dyscrasia. Churchill Livingstone, 1985.

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3

W, Delamore I., ed. Multiple myeloma and other paraproteinaemias. Churchill Livingstone, 1986.

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4

Bradwell, A. R. The binding site guide to paraprotein testing. University of Birmingham, 1994.

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5

Berden, Jo H. M., and Jack F. M. Wetzels. Immunological investigation of the patient with renal disease. Edited by Christopher G. Winearls. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0017.

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Laboratory techniques (electrophoresis, indirect immunofluorescence, ELISA, and immunoblotting) required for immunological investigation of the patient with renal disease are described. Renal disease-related aspects of immunoglobulins (immunoglobulin A, paraproteins, cryoglobulins), complement, antinuclear antibodies, anti-C1q antibodies, antineutrophil cytoplasmic antibodies, anti-glomerular basement membrane antibodies, antipodocyte antibodies, antiphospholipid antibodies, and antimicrobial responses (streptococci, hepatitis C, hepatitis B) are reviewed. Laboratory assays which evaluate the

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6

Korbet, Stephen M., Melvin M. Schwartz, and Edmund J. Lewis. Fibrillary and immunotactoid glomerulopathy. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0081.

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Fibrillary or immunotactoid nephropathy is a rare deposition disease of unknown cause in which highly organized deposits containing immunoglobulin and complement are found in the glomerular basement membrane and mesangium. These deposits are not amyloid fibrils and do not stain with Congo red. They are usually polyclonal and are not associated with monoclonal paraproteins, or with cryoglobulins or systemic lupus, distinguishing them from other non-amyloid fibrillary glomerulopathies. There is debate about whether there is a useful distinction between distinct fibrillary and rarer immunotactoid

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7

Jätzold, Christiane Elisabeth. Reevaluation immunelektrophoretisch detektierter Paraproteine mittels Immunfixation: Ein Methodenvergleich. 1990.

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8

Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Clinical approach. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0001.

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History taking in patients with haematological disease - Physical examination - Splenomegaly - Lymphadenopathy - Unexplained anaemia - Patient with elevated haemoglobin - Elevated white blood cell (WBC) count - Reduced WBC count - Elevated platelet count - Reduced platelet count - Easy bruising - Recurrent thromboembolism - Pathological fracture - Raised ESR - Serum or urine paraprotein - Anaemia in pregnancy - Thrombocytopenia in pregnancy - Prolonged bleeding after surgery - Positive sickle test (HbS solubility test)

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Hassan Al-Sader. Clinical approach. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0001_update_001.

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History taking in patients with haematological disease - Physical examination - Splenomegaly - Lymphadenopathy - Unexplained anaemia - Patient with elevated haemoglobin - Elevated white blood cell (WBC) count - Reduced WBC count - Elevated platelet count - Reduced platelet count - Easy bruising - Recurrent thromboembolism - Pathological fracture - Raised ESR - Serum or urine paraprotein - Anaemia in pregnancy - Thrombocytopenia in pregnancy - Prolonged bleeding after surgery - Positive sickle test (HbS solubility test)

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10

Fabrizi, Fabrizio, and Patrice Cacoub. The patient with cryoglobulinaemia. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0151.

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AbstractCryoglobulinaemia is characterized by the presence in the blood of proteins showing the that precipitate when serum is cooled. Clinically recognised cryoprecipitates are predominantly immunoglobulin-containing. In Type 1 cryoglobulinaemia, the precipitate is formed from a monoclonal paraprotein, usually IgG. In Type 2, a monoclonal IgM binds IgG to form a mixed precipitate. Type 3 cryoglobulins do not contain a monoclonal element.Type 1 cryoglobulins are a rare cause of renal disease, but cause a membranoproliferative glomerulonephritis (MPGN) with nephrotic syndrome and haematuria and

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Book chapters on the topic "Paraproteins"

1

Pioltelli, Pietro Enrico. "Paraproteins Associated with Malignancy." In Paraproteinemia and Related Disorders. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-10131-1_20.

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2

Holdenrieder, S., and P. Stieber. "Paraprotein." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2352-1.

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Holdenrieder, S., and P. Stieber. "Paraprotein." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2352.

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Berenson, J. R., A. K. Lichtenstein, J. Cao, S. Hart, D. Palomares, and R. A. Miller. "Racial Differences in the Expression of Shared Idiotypes by Paraproteins from Patients with Monoclonal Gammopathies." In Epidemiology and Biology of Multiple Myeloma. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76655-8_15.

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Baum, H. "IgM-Paraprotein." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_1515-1.

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Baum, H. "IgM-Paraprotein." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1515.

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7

Jolliff, Carl R. "Serum and Urine Paraprotein Capillary Electrophoresis." In Clinical and Forensic Applications of Capillary Electrophoresis. Humana Press, 2001. http://dx.doi.org/10.1007/978-1-59259-120-6_5.

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8

Picken, Maria M., and Ahmet Dogan. "Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond." In Current Clinical Pathology. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19294-9_12.

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Picken, Maria M. "Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond." In Amyloid and Related Disorders. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-60761-389-3_11.

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10

Farooq, Muhammad, Noriko Takahashi, Mark Drayson, John Lund, and Royston Jefferis. "A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myeloma." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5383-0_10.

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Conference papers on the topic "Paraproteins"

1

Grass, Sandra, Klaus-Dieter Preuss, Aleksandra Wikowicz, et al. "Abstract 1924: The paraproteins of patients with familial MGUS / multiple myeloma (MM) target family-specific antigens: Experience with paratarg-7 and paratarg-8." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1924.

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2

Venus, Cameron, Nawaf Yassi, Belinda Cruse, Mark Dowling, Monique Youl, and Edrich Rodrigues. "3119 A case of rapidly progressive neuropathy from poems syndrome with undetectable paraprotein." In ANZAN Annual Scientific Meeting 2024 Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjno-2024-anzan.108.

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Loureiro, G., LSA Rocha, DD Pereira, et al. "IMPORTÂNCIA DA QUANTIFICAÇÃO DAS CADEIAS LEVES KAPPA E LAMBDA LIVRES URINÁRIAS NO ESTUDO DAS PARAPROTEÍNAS." In Resumos do 54º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/1516-3180.140s1.7189.

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Objetivo: Avaliar a sensibilidade e a especificidade da dosagem das CLLs por imunoturbidimetria com relação à eletroforese e à imunofixação de proteínas urinárias. Método: Trinta e oito amostras de urina da rotina laboratorial (isolada e de 24 horas) foram avaliadas. Os exames de eletroforese e imunofixação das proteínas urinárias foram solicitados. A detecção das CLLs por eletroforese e imunofixação foi realizada no equipamento SPIFE II (Helena, USA). A dosagem quantitativa das CLL foi realizada por método imunoturbidimétrico, utilizando um conjunto diagnóstico da marca Freelite (Binding Site

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Pengo, V., M. J. Heine, P. Thiagarajan, and s. s. Shapiro. "A GENERAL MECHANISM FOR LUPUS ANTICOAGULANTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643660.

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Although- a number of observations have implied that lupus anticoagulants have immunologic specificity towards anionic. phospholipids, thereby prolonging phospholipid-dependent coagulation tests, this assumption has been directly demonstrated in only one patient with a monoclonal IgM paraprotein. We have tested the generality of this hypothesis directly by isolating five IgG lupus anticoagulants from patients with lupus-like syndromes and/or thrombosis. IgG lupus anticoagulant fractions were isolated free of other plasma proteins and free of contaminating phospholipid by adsorption to and elut

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