Academic literature on the topic 'Parathyroidectomy'

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Journal articles on the topic "Parathyroidectomy"

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El-Sayed, Yasser, and Atif Abdelatif. "FOCUSED PARATHYROIDECTOMY." Mansoura Medical Journal 33, no. 1 (April 1, 2004): 99–111. http://dx.doi.org/10.21608/mjmu.2004.127430.

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Duke, William S., Hampton M. Vernon, and David J. Terris. "Reoperative Parathyroidectomy." Otolaryngology–Head and Neck Surgery 154, no. 2 (November 25, 2015): 268–71. http://dx.doi.org/10.1177/0194599815619625.

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Biggar, Magdalena A., and Thomas W. J. Lennard. "Urgent parathyroidectomy." ANZ Journal of Surgery 82, no. 4 (March 21, 2012): 193–94. http://dx.doi.org/10.1111/j.1445-2197.2012.06002.x.

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Shepherd, J. "FAILED PARATHYROIDECTOMY." ANZ Journal of Surgery 68, no. 2 (February 1998): 87. http://dx.doi.org/10.1111/j.1445-2197.1998.tb04712.x.

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Ikeda, Y., and H. Takami. "Endoscopic parathyroidectomy." Biomedicine & Pharmacotherapy 54 (June 2000): 52s—56s. http://dx.doi.org/10.1016/s0753-3322(00)80011-6.

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Simental, Alfred, and Robert L. Ferris. "Reoperative Parathyroidectomy." Otolaryngologic Clinics of North America 41, no. 6 (December 2008): 1269–74. http://dx.doi.org/10.1016/j.otc.2008.05.008.

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Assalia, Ahmad, and William B. Inabnet. "Endoscopic parathyroidectomy." Otolaryngologic Clinics of North America 37, no. 4 (August 2004): 871–86. http://dx.doi.org/10.1016/j.otc.2004.02.017.

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Irvin, George L. "Quantitative Parathyroidectomy." Mayo Clinic Proceedings 69, no. 6 (June 1994): 605. http://dx.doi.org/10.1016/s0025-6196(12)62258-7.

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Silberfein, Eric J. "Reoperative Parathyroidectomy." Archives of Surgery 145, no. 11 (November 15, 2010): 1065. http://dx.doi.org/10.1001/archsurg.2010.230.

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Burkey, Shelby H. "Directed Parathyroidectomy." Archives of Surgery 138, no. 6 (June 1, 2003): 604. http://dx.doi.org/10.1001/archsurg.138.6.604.

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Dissertations / Theses on the topic "Parathyroidectomy"

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Nilsson, Inga-Lena. "Primary Hyperparathyroidism : A Study of Cardiovascular Dysfunction and its Reversibility After Parathyroidectomy." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5090-3/.

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UCHIDA, KAZUHARU, YUJI TANAKA, YOSHIHIRO TOMINAGA, and HIROSHI TAKAGI. "Surgery for Renal Hyperparathyroidism : Experience of 640 Cases." Nagoya University School of Medicine, 1997. http://hdl.handle.net/2237/16748.

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Choi, Joseph Do Woong. "The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure." Master's thesis, Canberra, ACT : The Australian National University, 2017. http://hdl.handle.net/1885/146626.

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Background Since the 1850s, parathyroid surgery continues to evolve through improved understanding of the pathophysiology. Dialysis dependant end stage renal failure (ESRF), the major cause of secondary hyperparathyroidism continues to rise in the western world. Other than renal transplantation, parathyroidectomy may provide a substantial cure for longstanding renal hyperparathyroidism in dialysis dependant patients. In 2004, cinacalcet was introduced as an alternative to the surgical management of renal hyperparathyroidism. However, cinacalcet was withdrawn from Australia’s Pharmaceutical Benefits Scheme (PBS) in 2015, as the EVOLVE study failed to demonstrate a statistically significant reduction in the time to death, or non-fatal cardiovascular events in those treated with cinacalcet with renal hyperparathyroidism. This led to a re-emergence in parathyroidectomy. Additionally in our institution, patients who had been on cinacalcet, and subsequently underwent parathyroidectomy because of refractory disease or intolerance to cinacalcet, were noted to experience greater hyperkalaemia and hypocalcaemia in the intraoperative and immediate postoperative period. Aims • To review the engrossing history of the discovery and progression of parathyroid surgery since the 19th century; • To correlate the embryology, anatomy, histology, physiology and pathophysiology of parathyroid glands in end stage renal failure; • To provide up to date review in regards to investigation and the surgical management of renal hyperparathyroidism; • Conduct a cohort study on the association of cinacalcet use with greater likelihood of intraoperative and immediate postoperative hyperkalaemia and hypocalcaemia following parathyroidectomy in renal hyperparathyroidism. Methods Literature reviews utilizing MEDLINE and Cochrane review databases, life science journals and textbooks were utilized. Hospital medical records from The Canberra Hospital were studied to collect data on the cohort case series. Analysis of data was performed using SPSS Statistics and Microsoft Excel. Results Sir Richard Owen is reputed to be the first person to discover the existence of parathyroid glands when examining a rhinoceros in 1852. In the spirit of mortui vivos docent, Captain Charles Martell in the 1930s had significantly increased our understanding of the existence of ectopic locations of parathyroid glands, as well as operative planning. The physiology and pathophysiology of parathyroid glands in chronic renal failure is multifaceted, with a complex interplay between bone, kidneys, intestine, vitamin D, potassium, phosphate and magnesium. There are a range of investigative strategies for localizing parathyroid glands, often yielding greater sensitivity and specificity when utilizing a combination of imaging tools. The choice of operative strategy for parathyroidectomy is often influenced by surgeon’s preference and the institution’s resources, due to paucity of good randomized trials and meta-analysis. Finally, our cohort study has shown that prior cinacalcet use was linked closely with severe intraoperative and immediate postoperative hyperkalaemia, and greater hypocalcaemia compared to control patients who underwent parathyroidectomy for renal hyperparathyroidism. Conclusions The continued inquiry into the basic sciences around renal hyperparathyroidism ensures that we are able to question traditional protocols, and practice the best evidence based medicine. From this, cinacalcet emerged to change the medical and surgical landscape in the treatment of hyperparathyroidism. The results of the cohort study led to development of a protocol for the perioperative management of renal hyperparathyroidism in cinacalcet treated patients requiring parathyroidectomy.
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Hagström, Emil. "Metabolic disturbances in relation to serum calcium and primary hyperparathyroidism /." Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6893.

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PALMIERI, SERENA. "IMPACT OF CHOLECALCIFEROL SUPPLEMENTATION ON SKELETAL AND NON-SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED UP WITHOUT SURGERY: CARDIOVASCULAR OUTCOMES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/865447.

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Context: Cardiovascular (CV) complications are a still debated issue in patients with biochemically mild primary hyperparathyroidism (PHPT) and may be related to both the PHPT condition itself and the hypovitaminosis D. Objective: To evaluate the prevalence, nature and reversibility of CV disease and associated risk factors in a large cohort of postmenopausal mild PHPT patients surgically cured (PTx Group) or observed for two years without surgical intervention (no-PTx Group). To preliminarily assess, in both group, if the administration of two different doses (800 UI and 2000 UI) of cholecalciferol (VitD) versus no supplementation could affect the CV disease evolution. Design: Randomized longitudinal prospective open label study. Settings: The study was conducted in the Endocrinology Unit of two university hospitals. Participants: 91 post-menopausal women with PHPT (38 in the PTx Group and 53 in the no-PTx Group) participated in the study. Outcome Measures: Cardiac and vascular damage (blood pressure, transthoracic echocardiography and carotid ultrasonography), lipids and glucose metabolism, renin-angiotensin system (RAAS) activity. Results: Arterial hypertension (AH) was found in 50.5% of patients and was not associated with PHPT after adjusting data for major CV risk factor. Diastolic dysfunction, LV hypertrophy and valve calcifications were diagnosed in 54.9%, 13.2% and 12.1% of patients and were respectively predicted by body mass index (BMI) and advancing age, by the presence of AH and by advancing age and the presence of AH, respectively. Similarly, advancing age was the only significant predictor of the presence of carotid plaque and AH was the only significant predictor of carotid intima-media thickness. We did not find any association between calcium, PTH or 25OHD and all glycemic parameters. No activation of RAAS was found in normotensive mild PHPT patients. All CV complications and risk factors were neither reversed nor significantly improved by surgery and/or VitD administration up to 24 months’ follow-up. Conclusions: The high incidence of CV disease and metabolic derangements reported in mild PHPT may be primarily related to the coexistence of AH, advanced age or increased BMI. Moreover, the administration of VitD supplements would seem to have a neutral effect at least as regards CV complications and CV risk factors in mild PHPT patients.
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Hagström, Emil. "Metabolic Disturbances in Relation to Serum Calcium and Primary Hyperparathyroidism." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6893.

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Primary hyperparathyroidism (pHPT), characterized by elevated serum levels of calcium and parathyroid hormone (PTH), is associated with a number of metabolic derangements causing secondary manifestations. These include osteoporosis and increased risk of fractures, but also risk factors for cardiovascular morbidity and mortality. These risk factors include impaired glucose tolerance (IGT), dyslipidemia, increased body mass index and hypertension. While the skeletal abnormalities are mainly due to elevated PTH, the latter disturbances are still unexplained. Non-insulin dependent diabetes mellitus (NIDDM), IGT, dyslipidemia and hypertension are all included in the metabolic syndrome, also associated with morbidity and mortality in cardiovascular diseases.

In this thesis, decreased bone mineral density (BMD) and variables of the metabolic syndrome are explored in patients with mild and normocalcemic pHPT before and after parathyroidectomy. To further investigate the relationship between insulin sensitivity and calcium, a community-based cohort was investigated.

In two different patient cohorts of pHPT, lipoprotein alterations with decreased levels of HDL-cholesterol and elevated triglycerides were found in association with a high frequency of IGT, NIDDM and decreased insulin sensitivity. Parathyroidectomy had effects on the dyslipidemia and in part on the glucose metabolism. The disturbed glucose metabolism in pHPT was substantiated by results from the general population by a negative association between insulin sensitivity, measured by hyperinsulinemic clamp, and serum calcium.

In conclusion, normocalcemic, mild and overt pHPT are associated with a range of risk factors for cardiovascular diseases, development of NIDDM and decreased BMD in cortical as well as trabecular bone. These findings explain, at least in part, the elevated morbidity and mortality from cardiovascular disease as well as fractures, reported in pHPT patients. Moreover, in the general population, serum calcium is associated with decreased insulin sensitivity. Parathyroidectomy has positive effects on several, but not all, of the investigated metabolic parameters.

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Santos, Stenio Roberto de Castro Lima. "Fatores preditivos da hipofunção do autoimplante de paratireóide em pacientes submetidos à paratireoidectomia total por hiperparatireoidismo secundário à insuficiência renal crônica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-23012013-101503/.

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O hiperparatireoidismo (HPT) secundário é uma complicação da doença renal crônica. A paratireoidectomia total com autoimplante proporciona bons resultados no seu tratamento, mas alguns doentes não desenvolvem níveis adequados de hormônio da paratireóide (PTH) após a operação. Os objetivos, do presente estudo, foram analisar fatores que poderiam interferir no funcionamento do autoimplante de glândula paratireóide e quantificar a taxa de hipofunção segundo alguns critérios. Casuística e Métodos: em um estudo prospectivo e observacional, foram analisados a idade, sexo, peso, altura e a etnia. A causa da doença renal crônica (DRC), tempo de DRC antes da paratireoidectomia, tempo de diálise, antecedente de intoxicação por alumínio e tempo de diagnóstico do HPT. Os dados bioquímicos estudados foram os níveis pré-operatórios de fósforo, cálcio total, cálcio iônico, PTH e fosfatase alcalina e aos 6 meses e 1 ano de pós-operatório. Registrada a quantidade de cálcio (gluconato e carbonato) e calcitriol ofertada no pós-operatório sendo realizada durante a primeira semana, no primeiro, terceiro sexto mês de pós-operatório. A histologia da glândula implantada foi analisada. Os pacientes foram divididos, segundo os níveis preconizados de PTH para indivíduos normais e segundo as recomendações da Fundação Nacional do Rim dos Estados Unidos da América (K/DOQI), em grupos hipofuncionante (grupo 1) e funcionante ( grupo 2). Resultados: Entre julho de 2007 e dezembro de 2008, 48 pacientes (18 homens e 30 mulheres) foram submetidos à paratireoidectomia total com autoimplante imediato. A média de idade dos indivíduos foi 44,7 anos (EP: 12,6), a do tempo de diálise foi 9,6 anos (EP: 5,1), a média do tempo de diagnóstico do hiperparatireoidismo de 2,6 anos (EP: 2). A principal causa da doença renal crônica foi a hipertensão arterial em 16 indivíduos (33,3%) seguida de causa indefinida em 12 (25%), GESF em 5 (10,4%), diabetes mellitus em 4 (8,3%). Com relação ao número de fragmentos implantados, houve tendência a uma diferença entre os grupos 1 e 2 (p= 0,14). Houve tendência a uma diferença entre os grupos 1 e 2 (p= 0,1) no que diz respeito a histologia da glândula implantada. O índice de hipofunção do auto implante, em 1 ano, foi de 21,27% no critério do nível de PTH para indivíduos normais e de 72,9% segundo as recomendações do KDOIQ. As complicações e óbitos por causa cardiovascular não diferiram entre os grupos. CONCLUSÃO: a frequência de hipofunção do implante imediato de paratireóide foi de 21,27% e de 72,9% segundo as recomendações do KDOQ e não houve a identificação de fatores preditivos para sua hipofunção.
The secondary hyperparathyroidism (HPT) is a complication of chronic kidney disease. A total parathyroidectomy with autograft provides good results in treatment, but some patients do not develop adequate levels of parathyroid hormone (PTH) after operation. The objectives of study were to analyze factors that could interfere with the function of the parathyroid gland autograft and measure the rate of hypofunction according several criteria. Patients and Methods: a prospective observational study were analyzed age, sex, weight, height and ethnicity. The cause of chronic kidney disease (CKD), duration of CKD prior to parathyroidectomy, duration of dialysis, previous aluminum intoxication and time of diagnosis of HPT. The biochemical data studied : preoperative levels of phosphorus, total calcium, ionized calcium, PTH and alkaline phosphatase and 6 months and 1 year postoperatively. Recorded the amount of calcium (gluconate and carbonate) and calcitriol offered postoperative being held during the first week, the first, third, sixth month postoperatively. Histology of the implanted gland was analyzed. Patients were divided according to the recommended levels of PTH for normal individuals and in accordance with the recommendations of the National Foundation Kidney the United States of America (K / DOQI) in hypofunction groups (group 1) and functional (group 2). Results: Between July 2007 and December 2008, 48 patients (18 men and 30 women) underwent total parathyroidectomy with immediate autograft. The mean age was 44.7 years (SE: 12.6), the duration of dialysis was 9.6 years (SE: 5.1), the average time of diagnosis of hyperparathyroidism 2.6 years (EP: 2). The main cause of chronic renal disease was hypertension in 16 patients (33.3%) followed by unknown cause in 12 (25%), FSGS in 5 (10.4%), diabetes mellitus in 4 (8.3%.). The number of implanted fragments, there was a trend to a difference between groups 1 and 2 (p = 0.14). There was a trend to a difference between groups 1 and 2 (p = 0.1) as regards the histology of the gland implanted. The rate of self hypofunction implant at 1 year was 21.27% at the discretion of the PTH level in normal individuals and 72.9% according to the recommendations of KDOIQ. Complications and deaths from cardiovascular causes did not differ between groups. CONCLUSION: The rate of hypofunction of the parathyroid immediate implant was 21.27% and 72.9% according to the recommendations of KDOIQ and there was no identification of predictive factors for its hypofunction.
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Coutinho, Flavia Lima. "Avaliação da densidade mineral óssea em pacientes com hiperparatireoidismo primário hereditário associado à neoplasia endócrina múltipla tipo 1, antes e após paratireoidectomia." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-16062009-171933/.

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INTRODUÇÃO: Hiperparatireoidismo primário (HPT) é uma doença endócrina relativamente comum, caracterizada por hipercalcemia associada a concentrações de PTH elevadas ou inapropriadamente normais. A maioria dos pacientes (90%-95%) apresenta a forma esporádica da doença, enquanto a forma familiar pode ocorrer associada à neoplasia endócrina múltipla tipo 1 (NEM1) e tipo 2, HPT-tumor de mandíbula, HPT neonatal severo e HPT isolada familiar. HPT associado com NEM1 (HPT/NEM1) difere da forma esporádica em vários aspectos, entre eles: acometimento multiglandular das paratireóides (hiperplasia x adenoma); início da doença mais precoce (20 x 40 anos); afeta homens e mulheres em proporção semelhante (1:1), em contraste a 1:3 no HPT esporádico; diferentes tratamentos cirúrgicos (paratireoidectomia total ou subtotal x adenomectomia); maior taxa de recorrência após paratireoidectomia (PTx); e tende a ser menos agressivo que o HPT esporádico. No HPT esporádico, o perfil da perda mineral óssea e o impacto do tratamento cirúrgico na densidade mineral óssea (DMO) estão bem definidos. Por outro lado, dados sobre perda óssea no HPT/NEM1 e sua potencial recuperação após PTx são escassamente relatados. O objetivo deste estudo é avaliar o perfil densitométrico e o impacto do tratamento cirúrgico na DMO em pacientes com HPT/NEM1. MÉTODOS: Neste estudo, avaliamos inicialmente 36 pacientes (18 homens e 18 mulheres) com diagnóstico de HPT/NEM1 (média de idade ao diagnóstico de HPT de 38,99 ± 14.46 anos, 20-74 anos). Estes pacientes pertenciam a oito famílias não relacionadas previamente caracterizadas clinicamente e portadoras de mutações germinativas MEN1. Avaliamos a DMO no terço proximal do rádio distal (1/3 RD), fêmur (colo do fêmur e fêmur total) e coluna lombar (L1-L4) destes 36 pacientes. A DMO foi medida pela densitometria óssea de dupla emissão com fonte de raios X (DXA) e os valores expressos em índice T, índice Z e em valores absolutos (g/cm2). Após esta avaliação da DMO, vinte e quatro pacientes foram submetidos à paratireoidectomia total seguida por auto-implante em antebraço não dominante. Em um grupo selecionado de 16 pacientes foi avaliada a densidade mineral óssea antes e após (período médio de 15 meses) o tratamento cirúrgico. RESULTADOS: Desmineralização óssea (osteoporose/osteopenia) foi observada no 1/3 RD (28/34, 79,4%); colo do fêmur (26/36, 72,7%) e na coluna lombar (25/36, 69,4%). Osteopenia foi principalmente observada no colo do fêmur (19/36, 52,8%), seguida pelo 1/3 RD (14/34, 41,2%) e coluna lombar (11/36, 30,5%). Osteoporose foi observada principalmente na coluna lombar (14/36, 38,9%) e 1/3 RD (14/34, 41,2%); enquanto no colo do fêmur (7/36, 19,4%) a prevalência foi menor . Valores médios de índice T estavam severamente reduzidos no 1/3 RD (- 2,46±1,436 DP), seguido pela coluna lombar (-2,05±1,539 DP). O colo do fêmur foi o menos afetado (-1,60±1,138 DP). Nos 16 pacientes submetidos ao tratamento cirúrgico, no período médio de 15 meses após PTx, a DMO (g/cm2) aumentou significativamente na coluna lombar de 0,843 para 0,909 g/cm2 (+ 8,4%; p=0,001). A DMO (g/cm2) no colo do fêmur também aumentou significativamente de 0,745 para 0,798 g/cm2 (+ 7,7%; p=0.0001). No 1/3 RD não houve modificação estatisticamente significante da DMO (0,627 ± 0,089 para 0,622 ± 0,075; p=0,76). CONCLUSÃO: Nossos dados demonstraram que o rádio distal é o sítio ósseo preferencial para desmineralização óssea e que a coluna lombar pode não estar relativamente protegida na HPT/MEN1, como descrito no HPT esporádico. Um aumento significante foi observado na coluna lombar e no colo do fêmur em pacientes com HPT/NEM1, em um período médio de 15 meses após paratireoidectomia; enquanto no terço proximal do radio distal, não houve melhora significativa durante este estudo
INTRODUTION: Primary hyperparathyroidism (HPT) is a relatively common endocrine disorder, which is characterized by hypercalcemia and elevated or inappropriately normal levels of PTH. Most patients (90-95%) present with the sporadic form of the disease, whereas familial cases may occur associated with multiple endocrine neoplasias type 1 (MEN1) and type 2, jaw tumours, as well as severe neonatal form and familial isolated HPT. HPT associated with MEN1 (HPT/MEN1) differs from sporadic primary HPT (s- HPT) in the following aspects: it presents as a multiglandular parathyroid neoplasia (hyperplasia vs adenoma); it has an earlier disease onset (20 vs. 40 years of age); there is a sex ratio of 1:1 in contrast to the 1:3 ratio for s- HPT; different surgical treatment (total or subtotal parathyroidectomy x adenomectomy); there are higher recurrence rates after a parathyroidectomy (PTx); and it frequently tends to be less aggressive than s-HPT. In s-HPT, the bone loss profile and the impact of parathyroid surgery are well defined. In contrast, data on bone losses in HPT/MEN1 and the potential bone recovery after PTx have been scarcely reported. The aim of this study is to evaluate the bone mineral status and the impact of surgical treatment on bone mineral density (BMD) in HPT/MEN1 patients. METHODS: We studied 36 cases (18 males and 18 females) diagnosed with HPT/MEN1 (average age at the HPT diagnosis of 38.9 ± 14.46 years; range, 20-74 years). These patients belonged to eight unrelated MEN1 families previously clinically characterized and harboring germline MEN1 mutations. We have assessed the values of BMD in the proximal one third distal radius (1/3 distal radius), femoral (femoral neck and total) and lumbar spine (L1-L4) of these 36 HPT/MEN1 cases. BMD values were measured by dual-energy X-ray absorptiometry and the values expressed in T, Z-score and in absolute values. After BMD analyses, twenty four out of them were submitted to total parathyroidectomy followed by autoimplant in the non-dominant forearm. BMD measurements were evaluated before and in a mean period of 15 months after surgery, in a subset of 16 patients. RESULTS: Bone demineralization (osteoporosis/osteopenia) was seen at the proximal third of distal radius (28/34, 79.4%); femoral neck (26/36, 72.7%) and in the lumbar spine (25/36, 69.4%). Osteopenia was mostly found in femoral neck (19/36, 52.8%), whereas 1/3 distal radius (14/34, 41.2%) and lumbar spine (11/36, 30.5%) were also represented. Osteoporosis was mostly marked at lumbar spine (14/36, 38.9%) and 1/3 DR (14/34, 41.2%), but femoral neck (7/36, 19.4%) was also affected. Mean T score values at the 1/3 DR were severely reduced (-2.46±1.436 SD), followed by lumbar spine (-2.05 ± 1.539 SD). The femoral neck was the least affected site (-1. 60 ± 1.138 SD). In the 16 cases submitted to surgical treatment, in a mean period of 15 months after PTX, BMD (g/cm2) significantly increased at the lumbar spine from 0.843 to 0.909 g/cm2 (+ 8.4%; p=0.001). Femoral neck BMD (g/cm2) also increased significantly from 0.745 to 0.798 g/cm2 (+ 7.7%; p=0.0001). In the proximal one third of distal radius, BMD (g/cm2) remained unchanged (baseline, 0.627 ± 0.089 to 0.622 ± 0.075; p=0.76). CONCLUSION: Our data confirmed distal radius as the preferential site of bone demineralization and that lumbar spine may not be relatively protected in HPT/MEN1, as related in the s-HPT. A significant increase in the BMD has been verified in the lumbar spine and femoral neck BMD in 16 patients with HPT/MEN1, in a mean period of 15 months after parathyroidectomy. However, the proximal one third of distal radius BMD did not present significant improvement during this study
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Silveira, André Albuquerque. "Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/.

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INTRODUÇÃO: A monitorização do paratormônio rápido (PTHr) é padrão no tratamento cirúrgico do hiperparatireoidismo primário, para garantir a retirada da paratireoide doente e preservação das saudáveis. Sua utilidade no tratamento cirúrgico do hiperparatireoidismo secundário à doença renal crônica é controversa. Esse estudo tem como objetivo verificar: 1) se a medida PTHr auxilia na predição do resultado cirúrgico precoce; 2) se existem diferenças de comportamento do PTHr entre pacientes dialíticos e transplantados; 3) se existem diferenças de comportamento do PTHr entre modalidades de operações distintas; 4) a acurácia do método em predizer controle do hiperparatireoidismo renal. MÉTODOS: Trata-se de estudo de coorte retrospectiva e prospectiva observacional, de pacientes com diagnóstico de HPTr, dialítico ou persistência após transplante renal, submetidos a paratireoidectomia total ou subtotal em único centro, no período de 2011 a 2016. Durante a cirurgia, realizamos coletas seriadas do PTHr, sendo três dessas amostras antes da exérese das glândulas paratireoides (basal periférico, basal central e pré-retirada), e duas após ressecção (10 min e 15 min). O critério de queda porcentual igual ou maior a 80% do maior valor entre as amostras basais, em 10 minutos, foi arbitrado preditor de êxito intra-operatório. Os pacientes foram seguidos durante intervalos regulares (15 dias, 3, 6 e 12 meses). Foram divididos em dois grupos (sucesso e falha da operação) de acordo com o controle dos níveis de PTH, cálcio e fósforo conforme consensos internacionais, ao término do seguimento de 1 ano. RESULTADOS: Duzentos e vinte e oito pacientes foram elegíveis, sendo 186 (81,6%) dialíticos e 42 (18,4%) transplantados. A paratireoidectomia alcançou sucesso em 92,1% (210/228) e falha em 7,9% (18/228) dos pacientes, sem diferenças de resultados entre grupos de diagnósticos diferentes e/ou tipos de operações distintas. O principal motivo de falha foi presença de glândula supranumerária, em 61,1% dos casos (11/18). A amostra basal central (BC) representou o real maior valor basal do PTHr para ambos os diagnósticos, porém com maior chance de picos do PTHr na amostra pré-retirada (PRE) nos pacientes transplantados. Após remoção da massa de tecido paratireóideo doente, os níveis de PTHr foram menores em 10 minutos quando comparados com as amostras basais (resultado estatisticamente significativo) para todos diagnósticos, tipos de operações e desfechos terapêuticos. No grupo sucesso, houve diferença estatisticamente significativa, entre as medidas de 10 e 15 minutos entre si, com valores menores em 15 minutos, enquanto que no grupo falha, sem distinção de 10 e 15 minutos entre si e com valores médios maiores em 15 min. Os valores do PTHr foram maiores no paciente dialítico quando comparados com transplantado, em todas as amostras (p < 0,001). No grupo sucesso, os pacientes dialíticos e transplantados, e os pacientes dialíticos submetidos a exérese total e subtotal apresentaram porcentual de queda do PTHr semelhantes em 10 e 15 minutos para as amostras BC e PRE; o paciente transplantado obteve decaimentos porcentuais menores quando houve ressecção subtotal. O grupo falha apresentou queda porcentual nitidamente menor e com significância estatística (p < 0,001), para todas amostra basais e em qualquer momento, quando comparado ao grupo sucesso. A função renal pré-operatória dos transplantados não influenciou a cinética de decaimento do PTHr (não teve correlação, p=0,09). A monitorização do PTHr influenciou a conduta cirúrgica em 7% (16/228) da casuística; o principal motivo foi a ocorrência de localização ectópica de umas das quatros paratireoides, responsável por 75% (12/16) dos casos. A paratireiodectomia bem sucedida exibiu impacto negativo na função do enxerto renal no pós-operatório, porém com posterior recuperação ao término de 1 ano. O método da dosagem do PTHr com o critério de 80% de queda, apresentou acurácia de 87%, sensibilidade de 88% e especificidade de 67% para a amostra BC em 15 minutos, e melhor especificidade (74%) na amostra PRE em 10 min. CONCLUSÕES: Em pacientes com hiperparatireoidismo renal, uso de medidas intra-operatórias do PTHr apresenta alta sensibilidade para indicar o sucesso da operação quando há redução de 80% dos valores iniciais. Apesar de valores absolutos diferentes, as taxas de redução desse hormônio após uma paratireoidectomia bem sucedida não são significativamente diferentes em pacientes dialíticos e transplantados, em operação total com auto-enxerto ou subtotal, com efetiva queda em 10 minutos de amostragem. A utilização de uma medida adicional 15 minutos após a retirada das glândulas aumenta a acurácia do método. A medida intra-operatória do PTHr pode auxiliar na tomada de decisões durante a operação desses pacientes
INTRODUCTION: Rapid Parathyroid Monitoring (rPTH) is standard in the surgical treatment of primary hyperparathyroidism, to ensure the excision of the diseased parathyroid and preservation of healthy parathyroid glands. Its usefulness in the surgical treatment of hyperparathyroidism secondary to chronic kidney disease is controversial. This study aims to verify: 1) whether the rPTH measure assists in the prediction of the early surgical outcome; 2) whether there are differences in rPTH pattern between dialytic and transplanted patients; 3) if there are differences in the decay of the rPTH between different operations modalities; 4) the accuracy of the method in predicting control of renal hyperparathyroidism. METHODS: This is a retrospective and prospective observational cohort study of patients with a diagnosis of PTH, dialysis or persistence after renal transplantation, who underwent total or subtotal parathyroidectomy in a single center from 2011 to 2016. During surgery, we performed serial samples of the rPTH, three of these were before excision of the parathyroid glands (peripheral basal, central basal and pre-withdrawal), and two after resection (10 min and 15 min). The criterion of percentage drop equal to or greater than 80% of the highest value of the basal samples, in 10 minutes, was arbitrated predictor of intraoperative success. Patients were followed at regular intervals (15 days, 3, 6 and 12 months). They were divided into two groups (success and failure of the operation) according to the control of the levels of PTH, calcium and phosphorus according to international consensus, at the end of the 1 year follow-up. RESULTS: Two hundred and twenty-eight patients were eligible, being 186 (81.6%) dialytic and 42 (18.4%) transplanted. Parathyroidectomy achieved success in 92.1% (210/228) and failure in 7.9% (18/228) of the patients, with no differences in results between groups of different diagnoses and/or different types of operations. The main reason for failure was the presence of supernumerary glands, 61.1% of the cases (11/18). The central basal (CB) sample represented the actual higher baseline PTHr for both diagnoses, but with a higher chance of rPTH peaks in the pre-withdrawal sample (PRE) in the transplanted patients. After removal of the diseased parathyroid tissue mass, rPTH levels were lower in 10 minutes compared to baseline (statistically significant) for all diagnoses, types of operations and therapeutic outcomes. In the success group, there was a statistically significant difference between the 10 and 15 minutes measurements, with smaller values in 15 minutes, while in the failure group, there was no distinction of 10 and 15 minutes between them and with mean values greater in 15 min. The rPTH values were higher in the dialytic patient when compared to transplanted in all samples (p < 0.001). In the success group, dialytic and transplanted patients, and dialytic patients submitted to total and subtotal excision, presented similar percent drop in rPTH at 10 and 15 minutes for CB and PRE samples; the transplanted patient had lower percentage decreases when subtotal resection. The failure group had a significantly lower percentage drop and with statistical significance (p < 0.001), for all baseline and at any time, when compared to the success group. The preoperative renal function of the transplanted patients did not influence the kinetics of rPTH decay (had no correlation, p=0.09). The rPTH monitoring influenced the surgical management in 7% (16/228) of the series; the main reason was the occurrence of ectopic localization of one of the four parathyroid glands, responsible for 75% (12/16) of the cases. In transplanted patients, successful parathyroidectomy had a negative impact on renal graft function in the postoperative period, but with a subsequent recovery at the end of 1 year. The rPTH dosage method with the 80% drop criterion showed an accuracy of 87%, a sensitivity of 88% and specificity of 67% for the CB sample in 15 minutes and a better specificity (74%) in the PRE sample in 10 min. CONCLUSION: In patients with renal hyperparathyroidism, the use of intraoperative measurements of rPTH has a high sensitivity to indicate the success of the operation when there is a reduction of 80% of the initial values. In spite of different absolute values, the rates of reduction of this hormone after successful parathyroidectomy are not significantly different in dialytic and transplant patients, in total autograft or subtotal operation, with an effective drop in 10 minutes of sampling. The use of an additional measurement 15 minutes after removal of the glands increases the accuracy of the method. The intraoperative measurement of rPTH may aid in decision making during the operation of these patients
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Barreira, Carlos Eduardo Santa Ritta. "Análise da ultra-estrutura do tecido paratireóideo humano em solução para preservação de tecidos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-28052010-115506/.

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INTRODUÇÃO: A criopreservação de tecido paratireóideo é empregada no tratamento cirúrgico do hiperparatireoidismo secundário nos pacientes com doença renal crônica. Entre a captação do tecido e a criopreservação, realizada em laboratório especializado, o tecido é preservado em solução para cultura de células a 4°C (solução para transporte). Não há dados que demonstrem por quanto tempo o tecido paratireóideo humano pode permanecer viável nesta solução, antes de ser criopreservado. Este estudo objetiva avaliar o período de tempo que o tecido da glândula paratireóide hiperplásica de humanos pode permanecer na solução para transporte, sem apresentar danos ultra-estruturais. MÉTODOS: Estudo prospectivo que incluiu 11 pacientes submetidos a paratireoidectomia total com autoimplante heterotópico e criopreservação de fragmentos de tecido paratireóideo. Parte do tecido destinado para exame anatomopatológico foi selecionado para preservação em solução para transporte. Foram definidos 5 períodos relacionados ao tempo de permanência dos fragmentos de paratireóide na solução para transporte. No tempo 1, o material foi fixado a fresco, sem contato com a solução para transporte, este tempo serviu para controle. No tempo 2, os fragmentos de tecido permaneceram imersos na solução para transporte por 2 horas, no tempo 3, este período foi de 6 horas, e os tempos 4 e 5, corresponderam a preservação dos fragmento de paratireóide na solução para transporte por 12 e 24 horas respectivamente. Ao final de cada período os fragmentos foram removidos da solução de transporte e fixados com glutaraldeído a 2%, seguido por preparo do material para cortes ultrafinos. A análise por microscopia eletrônica avaliou a adesão celular e a integridade das membranas plasmáticas, dos núcleos e das mitocôndrias, além da presença de edema celular e de vacúolos. RESULTADOS: Dos 11 casos estudados, 10 apresentaram achados ultraestruturais compatíveis com a normalidade nos fragmentos de tecido que permaneceram na solução para transporte por até 12 horas. Em apenas um destes casos, houve preservação das características morfológicas do tecido por 24 horas, na solução para transporte. Em um caso os achados caracterizaram sinais de dano celular irreversível em todos os períodos, inclusive no tempo inicial, em que o tecido foi fixado a fresco, sem contato com a solução para transporte. As alterações das mitocôndrias representaram os danos ultra-estruturais mais constantes nos casos estudados. CONCLUSÃO: A análise da ultra-estrutura do tecido da glândula paratireoide hiperplásica de humanos permite concluir que ocorre manutenção adequada da integridade estrutural do tecido que permanece na solução com meio de cultura de células a 4°C.até cerca de 12 horas após sua retirada do organismo, na maioria dos casos.
BACKGROUND: The cryopreservation of parathyroid tissue is employed in the surgical treatment of secondary hyperparathyroidism in patients with chronic kidney disease. During the period between surgical resection and cryopreservation of tissue, which requires a specialized laboratory, the tissue is stored in a cell culture solution, at 4 °C (solution for transport from the operating room to the laboratory). There is no data showing for how long the human parathyroid tissue can remain viable in this solution, before being cryopreserved. The present study evaluates the time that the tissue of human hyperplastic parathyroid gland could remain in solution for transportation, without showing ultrastructural damages. METHODS: This prospective study included 11 patients, who underwent total parathyroidectomy with heterotopic autotransplantation and cryopreservation of parathyroid tissue fragments. Part of the tissue intended for pathological examination was selected for storage at solution for transportation. Five periods were defined, related to the storage time of parathyroid fragments at solution for transportation. At time 1, the material was fixed at the time of surgical resection, without contact with the solution for transport, this time was used as control. At time 2, the fragments of tissue remained stored at the solution for transportation for 2 hours, at time 3, this period was 6 hours, and Times 4 and 5, corresponded to the parathyroid fragments stored in the transport solution for 12 and 24 hours, respectively. At the end of each period the fragments were removed from the transport solution and fixed with 2% glutaraldehyde, followed by preparation of material for ultrathin sections. The analysis by electron microscopy was used to evaluate cell adhesion and integrity of plasma membranes, nuclei and mitochondria, and the presence of edema and cell vacuoles. RESULTS: Of the 11 cases studied, 10 showed ultrastructural findings consistent with the normal tissue fragments that remained in the solution to transport up to 12 hours. In only one of these cases, there was preservation of the morphological characteristics of the tissue for 24 hours, at the solution for transportation. In one case, there were findings of marked signs of irreversible cell damage in all periods, including the initial time in which the tissue was fixed at the time of surgical resection, without contact with the solution for transportation. Changes of mitochondria represented the ultrastructural damage more constant in the cases studied. CONCLUSION: The analysis of the ultrastructure of human hyperplastic parathyroid gland tissue shows that, in most cases, ultrastructural integrity is properly maintained in fragments stored up to 12 hours in a solution of cell culture, at 4° C.
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Books on the topic "Parathyroidectomy"

1

Feliz, Arcelia. Coloring Book - You Will Get Better - Parathyroidectomy. Independently Published, 2021.

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Kwon, Rachel J. Minimally Invasive Parathyroidectomy versus Conventional Surgery for Primary Hyperparathyroidism. Edited by Randall Owen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199384075.003.0043.

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This chapter provides a summary of a landmark study in endocrine surgery. Is minimally invasive parathyroidectomy better than conventional bilateral cervical exploration for the treatment of primary hyperparathyroidism with respect to cure rates and complication rates? Starting with that question, it describes the basics of the study, including year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case on minimally invasive parathyroidectomy.
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Ford, Pete. Endocrine surgery. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198719410.003.0023.

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Agarwal, Anil, Neil Borley, and Greg McLatchie. Endocrine surgery. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199608911.003.0006.

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This chapter provides information on common endocrine operations. Techniques of ultrasound—guided fine-needle aspiration cytology of a thyroid nodule is described. Operations of total thyroidectomy, hemithyroidectomy, bilateral neck exploration, and minimally invasive parathyroidectomy (MIP), and open and both laparoscopic transperitoneal and retroperitoneal adrenalectomy are described.
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Nilsson, Inga-Lena. Primary Hyperparathyroidism: A Study of Cardiovascular Dysfunction & Its Reversibility After Parathyroidectomy (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1066). Uppsala Universitet, 2001.

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Voinescu, Alexandra, Nadia Wasi Iqbal, and Kevin J. Martin. Management of chronic kidney disease-mineral and bone disorder. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0118_update_001.

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In all patients with chronic kidney disease (CKD) stages 3–5, regular monitoring of serum markers of CKD-mineral and bone disorder, including calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25-hydroxyvitamin D, and alkaline phosphatase, is recommended. Target ranges for these markers are endorsed by guidelines. The principles of therapy for secondary hyperparathyroidism include control of hyperphosphataemia, correction of hypocalcaemia, use of vitamin D sterols, use of calcimimetics, and parathyroidectomy. of hyperphosphataemia is crucial and may be achieved by means of dietary P restriction, use of P binders, and P removal by dialysis. Dietary P restriction requires caution, as it may be associated with protein malnutrition. Aluminium salts are effective P binders, but they are not recommended for long-term use, as Aluminium toxicity (though from contaminated dialysis water rather than oral intake) may cause cognitive impairment, osteomalacia, refractory microcytic anaemia, and myopathy. Ca-based P binders are also quite effective, but should be avoided in patients with hypercalcaemia, vascular calcifications, or persistently low PTH levels. Non-aluminium, non-Ca binders, like sevelamer and lanthanum carbonate, may be more adequate for such patients; however, they are expensive and may have several side effects. Furthermore, comparative trials have failed so far to provide conclusive evidence on the superiority of these newer P binders over Ca-based binders in terms of preventing vascular calcifications, bone abnormalities, and mortality. P removal is about 1800–2700 mg per week with conventional thrice-weekly haemodialysis, but may be increased by using haemodiafiltration or intensified regimens, such as short daily, extended daily or three times weekly nocturnal haemodialysis. Several vitamin D derivatives are currently used for the treatment of secondary hyperparathyroidism. In comparison with the natural form calcitriol, the vitamin D analogue paricalcitol seems to be more fast-acting and less prone to induce hypercalcaemia and hyperphosphataemia, but whether these advantages translate into better clinical outcomes is unknown. Calcimimetics such as cinacalcet can significantly reduce PTH, Ca, and P levels, but they have failed to definitively prove any benefits in terms of mortality and cardiovascular events in dialysis patients. Parathyroidectomy is often indicated in CKD patients with severe persistent hyperparathyroidism, refractory to aggressive medical treatment with vitamin D analogues and/or calcimimetics. This procedure usually leads to rapid improvements in biochemical markers (i.e. significant lowering of serum Ca, P, and PTH) and clinical manifestations (such as pruritus and bone pain); however, the long-term benefits are still unclear.
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Elder, Grahame J. Metabolic bone disease after renal transplantation. Edited by Jeremy R. Chapman. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0288.

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Patients who undergo kidney transplantation have laboratory, bone, and soft tissue abnormalities that characterize chronic kidney disease mineral and bone disorder (CKD-MBD). After successful transplantation, abnormal values of parathyroid hormone, fibroblast growth factor 23, calcium, phosphate, vitamin D sterols, and sex hormones generally improve, but abnormalities often persist. Cardiovascular risk remains high and is influenced by prevalent vascular calcification, and fracture risk increases due to a combination of abnormal bone ‘quality’, compounded by immunosuppressive drugs and reductions in bone mineral density. Patients with well managed CKD-MBD before transplantation generally have a smoother post-transplant course, and it is useful to assess patients soon after transplantation for risk factors relevant to the general population and to patients with CKD. Targeted laboratory assessment, bone densitometry, and X-ray of the spine are useful for guiding therapy to minimize post-transplant effects of CKD-MBD. To reduce fracture risk, general measures include glucocorticoid dose minimization, attaining adequate 25(OH)D levels, and maintaining calcium and phosphate values in the normal range. Calcitriol or its analogues and antiresorptive agents such as bisphosphonates may protect bone from glucocorticoid effects and ongoing hyperparathyroidism, but the efficacy of these therapies to reduce fractures is unproven. Alternate therapies with fewer data include denosumab, strontium ranelate, teriparatide, oestrogen or testosterone hormone replacement therapy, tibolone, selective oestrogen receptor modulators, and cinacalcet. Parathyroidectomy may be necessary, but is generally avoided within the first post-transplant year. A schema is presented in this chapter that aims to minimize harm when allocating therapy.
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Book chapters on the topic "Parathyroidectomy"

1

Morris, Lilah F., and Michael W. Yeh. "Parathyroidectomy." In Illustrative Handbook of General Surgery, 39–50. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-24557-7_4.

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Mansfield, Sara A., and Jennifer H. Aldrink. "Parathyroidectomy." In Operative Dictations in Pediatric Surgery, 387–89. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24212-1_99.

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Neymark, Mariya, Haggi Mazeh, and Michal Mekel. "Parathyroidectomy." In Atlas of Parathyroid Surgery, 35–44. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-40756-8_4.

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Schmiedt, Chad. "Parathyroidectomy." In Complications in Small Animal Surgery, 193–97. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119421344.ch27.

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Gurll, Nelson J. "Parathyroidectomy." In Chassin’s Operative Strategy in General Surgery, 906–11. New York, NY: Springer New York, 2002. http://dx.doi.org/10.1007/978-0-387-22532-6_108.

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Sarpel, Umut. "Parathyroidectomy." In Surgery, 207–17. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0903-2_19.

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Simental, Alfred, and Robert L. Ferris. "Parathyroidectomy." In Encyclopedia of Otolaryngology, Head and Neck Surgery, 2066–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_166.

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Morris, Lilah F., and Michael W. Yeh. "Parathyroidectomy." In Illustrative Handbook of General Surgery, 23–28. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-089-0_4.

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Nowlin, William F. "Parathyroidectomy." In Advanced Surgical Techniques for Rural Surgeons, 147–55. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-1495-1_18.

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Dream, Sophie. "Parathyroidectomy." In Common Surgeries Made Easy, 261–65. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41350-7_44.

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Conference papers on the topic "Parathyroidectomy"

1

Wang, Yuanyuan, Xi Zhang, Peisong Wang, Yanhua Li, Zhi Lv, and Guang Chen. "Intraoperative Parathyroid Hormone Monitoring in Parathyroidectomy for PHPT." In 2016 8th International Conference on Information Technology in Medicine and Education (ITME). IEEE, 2016. http://dx.doi.org/10.1109/itme.2016.0056.

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Sousa, Andreia Coimbra, Victor Hugo Ferreira e. Léda, Victor Caires Tadeu, Leticia Queiroga de Figueiredo, Isabele Parente de Brito Antonelli, and Ricardo Fuller. "PARATHYROIDECTOMY AS A TRIGGER FOR CALCIUM PYROPHOSPHATE CRYSTALS ARTHRITIS." In XXXIX Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2022. http://dx.doi.org/10.47660/cbr.2022.2216.

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Loufopoulos, Panos, Spyridon Miliaras, Georgios Tsoulfas, Georgia Koutsouki, Evanthia Giannoula, and Ioannis Iakovou. "The Application of Radio-Guided Occult Lesion Localization to the Minimal-Invasive Parathyroidectomy." In 6th International Conference on Radiopharmaceutical Therapy (ICRT 2021) Abstracts. Thieme Medical and Scientific Publishers Pvt. Ltd., 2022. http://dx.doi.org/10.1055/s-0042-1749242.

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Azad, T., B. Kesavan, and K. Manoharan. "B54 Bilateral superficial cervical plexus block for awake parathyroidectomy in a high risk patient." In ESRA Abstracts, 39th Annual ESRA Congress, 22–25 June 2022. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/rapm-2022-esra.129.

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Azad, T., B. Kesavan, and K. Manoharan. "LB20 Bilateral superficial cervical plexus block for awake parathyroidectomy in a high risk patient." In ESRA Abstracts, 39th Annual ESRA Congress, 22–25 June 2022. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/rapm-2022-esra.539.

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Inmutto, Nakarin, Tanop Srisuwan, Thanate Kattipatanapong, and Prach Pochan. "Comparative Effectiveness of Percutaneous Ethanol Injection Therapy and Parathyroidectomy in the Treatment of Secondary and Tertiary Hyperparathyroidism." In PAIRS Annual Meeting. Thieme Medical and Scientific Publishers Pvt. Ltd., 2018. http://dx.doi.org/10.1055/s-0041-1730675.

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Reports on the topic "Parathyroidectomy"

1

Pons, Aina, Annalisa Hauck, and Tarek Abdel Aziz. On Indocyanine Green Fluorescence and Autofluorescence in thyroid and parathyroid surgery: A systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0067.

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Review question / Objective: Autofluorescence (AF) and Indocyanine Green Fluorescence (ICG) were used for the first time for parathyroid gland (PG) identification in 2011 and 2015, respectively, during thyroidectomy/parathyroidectomy. Authors reported promising results. We aim to understand the efficacy, technical challenges, cost-effectiveness, and impact on postoperative biochemical and clinical outcomes of such new techniques. Eligibility criteria: The language filter was set to allow for publications in English, German, Spanish, and French assessing the use of ICG and/or AF for PG identification. Only titles and abstracts, followed by the full text dating from 2008 to 2020 have been considered in this review. Existing systematic reviews were excluded from the results.
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