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Journal articles on the topic 'Parenchymal tumor cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wolf, Gregory T., Jerry L. Hudson, Karen A. Peterson, Harriet L. Miller, and Kenneth D. Mcclatchey. "Lymphocyte Subpopulations Infiltrating Squamous Carcinomas of the Head and Neck: Correlations with Extent of Tumor and Prognosis." Otolaryngology–Head and Neck Surgery 95, no. 2 (1986): 142–52. http://dx.doi.org/10.1177/019459988609500203.

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Because little is known about the mechanisms involved in local tumor-host immune reactions in squamous carcinoma of the head and neck, a study was undertaken to better characterize the types of immune cells present at the local tumor site and determine their relationship to tumor extent, systemic cellular immune parameters, and clinical outcome. In 40 untreated patients, lymphocyte subsets (LS) at the tumor-host interface were quantitated immunohistologically from serial sections of frozen tumor specimens and correlated with concurrently measured peripheral LS levels and in vitro lymphocyte re

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Szabo, Peter M., George Lee, Scott Ely, et al. "CD8+ T cells in tumor parenchyma and stroma by image analysis (IA) and gene expression profiling (GEP): Potential biomarkers for immuno-oncology (I-O) therapy." Journal of Clinical Oncology 37, no. 15_suppl (2019): 2594. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.2594.

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2594 Background: Distribution patterns of CD8+ T cells within the tumor microenvironment (TME) can be assessed by IA, which may reflect underlying tumor biology and serve as a potential biomarker to assess the utility of I-O therapy. These patterns are variable and may be classified as immune desert (minimal infiltrate), excluded (T cells confined to tumor stroma or to the invasive margin), or inflamed (T cells diffusely infiltrating tumor parenchyma and stroma). We hypothesized that association of a GEP signature with abundance of parenchymal and stromal T-cell infiltrates may identify biomar

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Nwajei, Felix, Meenakshi Shanmugasundaram, Dana Paine, et al. "Brain tumor-induced neuronal stress orchestrates adaptive immune surveillance through fractalkine." Journal of Immunology 200, no. 1_Supplement (2018): 178.13. http://dx.doi.org/10.4049/jimmunol.200.supp.178.13.

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Abstract Tissue damage contributes to initiation and modulation of an immune response. Tumor progression generally causes distress to the surrounding tissue. However, how tumor-induced parenchymal damage regulates anti-tumor immune response remains to be understood. We found that tumors that invaded brain parenchyma compressed the surrounding neurons causing increased expression of the neuronal chemokine CX3CL1/fractalkine in the peritumoral margin. Intravital two-photon microscopy revealed perivascular recruitment of monocyte-derived CD11c+ dendritic cells and T cells that interacted and kill

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BD, Impana, Seethalakshmi S, and Raghavendran R. "A rare and challenging case of pineal gland tumor – A case report." IP Journal of Diagnostic Pathology and Oncology 8, no. 3 (2023): 181–84. http://dx.doi.org/10.18231/j.jdpo.2023.043.

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Pineal gland tumors are of rare occurrence and may arise from pineal parenchymal cells, the neighboring glia or residual stem cells. Due to its rarity pineal gland tumors are often misdiagnosed. The World Health Organsation (WHO) classifies and grades pineal parenchymal tumors from grade I to grade IV. We present a case report of a rare pineal parenchymal tumor (PPT) in an adult female which was diagnosed mainly on histopathology and aided by immunohistochemistry. The case report includes review of histopathological features and grading of pineal region tumors of intermediate malignancy which

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Takabatake, Kiyofumi, Hotaka Kawai, Haruka Omori, et al. "Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma." International Journal of Molecular Sciences 21, no. 20 (2020): 7714. http://dx.doi.org/10.3390/ijms21207714.

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Solid tumors consist of the tumor parenchyma and stroma. The standard concept of oncology is that the tumor parenchyma regulates the tumor stroma and promotes tumor progression, and that the tumor parenchyma represents the tumor itself and defines the biological characteristics of the tumor tissue. Thus, the tumor stroma plays a pivotal role in assisting tumor parenchymal growth and invasiveness and is regarded as a supporter of the tumor parenchyma. The tumor parenchyma and stroma interact with each other. However, the influence of the stroma on the parenchyma is not clear. Therefore, in this

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Kälin, Roland, Linzhi Cai, Yuping Li, et al. "OTME-1. TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression." Neuro-Oncology Advances 3, Supplement_2 (2021): ii13. http://dx.doi.org/10.1093/noajnl/vdab070.052.

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Abstract Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP) that transiently appeared during glioblastoma growth. TAMEP of mice and humans were identi

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Kälin, Roland, Linzhi Cai, Dongxu Zhao, et al. "Local progenitor cells shape the neoplastic vasculature and promote brain tumor growth." Journal of Clinical Oncology 39, no. 15_suppl (2021): e14044-e14044. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e14044.

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e14044 Background: Aggressive brain tumors like glioblastoma depend on support by their local environment. While the role of tumor-associated myeloid cells on glioblastoma progression is well-documented, we have only partial knowledge of the pathological impact of glioblastoma -parenchymal progenitor cells. Methods: We investigated the glioblastoma microenvironment with transgenic lineage-tracing models ( nestin-creER2, R26-tdTomato and sox2-creER2,R26-tdTomato), intravital imaging, single-cell transcriptomics, immunofluorescence and flow-cytometry as well as histopathology and characterized a

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Sulistyo, Eko, and Ildsa Maulidya Mar’athus N. "DIFFERENCE IMPLEMENTATION OF T1WI SE AND T1WI FSPGR BRAVO SEQUENTS IN MRI BRAIN TUMOR." Journal of Applied Health Management and Technology 1, no. 1 (2019): 23–27. http://dx.doi.org/10.31983/jahmt.v1i1.5307.

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Tumor is basically an uncontrolled growth of cancerous cells in any part of the body, whereas a brain tumor is an uncontrolled growth of cancerous cells in the brain. Useing of MRI in diagnose tumors can be done with various sequences. Contrast medium is needed to evince tumor enhancement, as well as sequences that support to produce tumor in post contrast, one of which uses a conventional sequence T1WI SE. This sequences often lose information in providing images in cases of brain tumors and generally more time consuming. FSPGR BRAVO is a 3D volumetric acquisition that captures thin section i

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Chekol, Seble S., and Chen-Chin Sun. "Malignant Mesothelioma of the Tunica Vaginalis Testis: Diagnostic Studies and Differential Diagnosis." Archives of Pathology & Laboratory Medicine 136, no. 1 (2012): 113–17. http://dx.doi.org/10.5858/arpa.2010-0550-rs.

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Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. Gross examination of testicular mesotheliomas typically reveals tumor nodules studding the thickened tunica vaginalis and, in some cases, infiltrating the testicular parenchyma, leading to diagnostic challenges. Microscopically, the tumor is characterized by epithelioid cells arising from the tunica vaginalis with papillary, tubulopapillary, or solid architectural patterns. The papillae are usually lined by a single layer of cells with relatively bland cytolo

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Jiang, Wulin, Alain Valdivia, Alison Mercer-Smith, Carey Anders, and Shawn Hingtgen. "EXTH-02. TUMOR-HOMING INDUCED NEURAL STEM CELL THERAPY INHIBITS THE PROGRESSION OF BREAST CANCER BRAIN METASTASIS AND LEPTOMENINGEAL CARCINOMATOSIS." Neuro-Oncology 22, Supplement_2 (2020): ii86—ii87. http://dx.doi.org/10.1093/neuonc/noaa215.356.

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Abstract INTRODUCTION Breast cancer brain metastasis, including leptomeningeal carcinomatosis (LC), remains one of the most lethal CNS diseases. New therapies are urgently needed to treat this highly aggressive disease. Here we used models of both breast cancer brain parenchymal metastasis and leptomeningeal metastasis to investigate the efficacy of engineered tumor-homing neural stem cells (NSCs) therapy. METHODS Personalized NSCs were created using Sox2 overexpression to transdifferentiate human fibroblasts into induced NSCs (iNSCs), followed by genetic engineering to enable iNSCs to secrete

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Corchado-Cobos, Roberto, Natalia García-Sancha, Marina Mendiburu-Eliçabe, et al. "Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer." Cancers 14, no. 2 (2022): 322. http://dx.doi.org/10.3390/cancers14020322.

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Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor

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Kälin, Roland, Linzhi Cai, Yuping Li, Ines Hellmann, and Rainer Glass. "TAMI-36. TAMEP ARE BRAIN TUMOR PARENCHYMAL CELLS CONTROLLING NEOPLASTIC ANGIOGENESIS AND PROGRESSION." Neuro-Oncology 23, Supplement_6 (2021): vi205—vi206. http://dx.doi.org/10.1093/neuonc/noab196.820.

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Abstract Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor-parenchymal cells may promote specific phases of disease-progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP) that transiently appeared during glioblastoma growth. TAMEP of mice and humans were identi

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Weiskirchen, Ralf, and Frank Tacke. "Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease." Cells 8, no. 1 (2019): 16. http://dx.doi.org/10.3390/cells8010016.

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Autophagy is a highly conserved intracellular process for the ordered degradation and recycling of cellular components in lysosomes. In the liver, parenchymal cells (i.e., mainly hepatocytes) utilize autophagy to provide amino acids, glucose, and free fatty acids as sources of energy and biosynthesis functions, but also for recycling and controlling organelles such as mitochondria. Non-parenchymal cells of the liver, including endothelial cells, macrophages (Kupffer cells), and hepatic stellate cells (HSC), also employ autophagy, either for maintaining cellular homeostasis (macrophages, endoth

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Suzuki, Takamoto, Yukimasa Yasumoto, Kazuo Kumami, et al. "Primary pineal melanocytic tumor." Journal of Neurosurgery 94, no. 3 (2001): 523–27. http://dx.doi.org/10.3171/jns.2001.94.3.0523.

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✓ A primary melanocytic lesion arising from the pineal gland is very rare. The authors report a case of primary pineal melanocytic tumor with dissemination to the right hippocampus in a 50-year-old woman who presented with memory disturbance. Magnetic resonance (MR) imaging revealed a mass that was hyperintense on T1-weighted and hypointense on T2-weighted MR images. The pineal tumor was removed subtotally via the occipital transtentorial approach, and the patient underwent whole-brain irradiation. Results of histological examination revealed that the tumor predominantly consisted of atypical

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Lee, Wen-Jui, Shih-Hsin Tu, Tzu-Chun Cheng, et al. "Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues." Molecules 26, no. 21 (2021): 6548. http://dx.doi.org/10.3390/molecules26216548.

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The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular matrix can attenuate the invasion of human breast tumor cells. Decreased HA levels in subcutaneous Has3-KO mouse tissues promoted orthotopic breast cancer (E0771) cell-derived allograft tumor growth. MDA-MB-231 cells premixed with higher concentration HA attenuate tumor growth in xenografted nude mice. Human patient-derived xenotransplantation (

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Thorn, Stephanie R., Stig Purup, Mogens Vestergaard, et al. "Regulation of mammary parenchymal growth by the fat pad in prepubertal dairy heifers: role of inflammation-related proteins." Journal of Endocrinology 196, no. 3 (2007): 539–46. http://dx.doi.org/10.1677/joe-07-0501.

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In prepubertal heifers, the mammary parenchyma consists of epithelial and myoepithelial cells growing within a mammary fat pad (MFP). The MFP produces IGF-I that stimulates epithelial cell proliferation. In other species, adipose tissue expansion induces inflammation-related proteins (IRP), such as tumor necrosis factor α (TNFα), interleukin (IL)-6, IL-1β transforming growth factor β, monocyte chemoattractant protein 1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1). The MFP production of IRP may influence mammary development because they impair not only insulin but also IGF-I actions.

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Kälin, Roland E., Linzhi Cai, Yuping Li, et al. "TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression." Cell Systems 12, no. 3 (2021): 248–62. http://dx.doi.org/10.1016/j.cels.2021.01.002.

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Kälin, R., L. Cai, Y. Li, et al. "TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression." Brain and Spine 1 (2021): 100468. http://dx.doi.org/10.1016/j.bas.2021.100468.

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19

Zavyalova, M. V., A. V. Zavyalov, E. S. Pudova, et al. "Generalized lymphogenous metastasis involving parenchymal organs in gastric cancer (case report)." Siberian journal of oncology 24, no. 1 (2025): 189–98. https://doi.org/10.21294/1814-4861-2025-24-1-189-198.

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Generalized metastases to parenchymatous organs in gastric cancer are usually associated with hematogenous spread of cancer cells. Generalized lymphogenous metastasis involves the spread of cancer cells to distant lymph nodes and serous membranes. There is very little information on generalized metastases to parenchymatous organs due to tumor embolism of their lymphatic vessels. Objective: to present a fatal case with generalized lymphogenous metastases to parenchymatous organs. Case presentation. A 56-year-old female patient with gastric cancer presented to the hospital with generalized lymph

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Korf, Horst W., Jeffrey A. Bruce, Barbara Vistica, Mark Rollag, Bennett M. Stein, and David C. Klein. "Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors?" Journal of Neurosurgery 70, no. 5 (1989): 682–87. http://dx.doi.org/10.3171/jns.1989.70.5.0682.

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✓ This investigation evaluated the possibility that the occurrence of S-antigen in cerebrospinal fluid (CSF) might be used as a preoperative marker of pineal parenchymal tumors (pineoblastoma and pineocytoma). Such a marker could provide a means of preoperatively differentiating these neoplasms from pineal region tumors of other origin. The S-antigen, also known as the 48-kD protein or arrestin, is a highly antigenic protein originally found in the retina and pineal gland. In the retinal photoreceptors and submammalian pineal photoreceptors the protein is thought to be involved in phototransdu

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Nogueira, Adriano Barreto, Ariel Barreto Nogueira, Anderson Lino Costa, Fabiana Roberto Lima, Sheila Aparecida Siqueira, and Manoel Jacobsen Teixeira. "Hepatocellular carcinoma may display elevated nestin expression in endothelial cells: experimental study." Sao Paulo Medical Journal 133, no. 2 (2015): 135–40. http://dx.doi.org/10.1590/1516-3180.2014.8670910.

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CONTEXT AND OBJECTIVE: Nestin, a class VI intermediate filament protein, is highly expressed in the portal mesenchyme and sinusoidal endothelium of the human fetal liver, but scarcely expressed in adult portal vessel endothelium. During experimental liver regeneration, an increased number of nestin-positive parenchymal cells have been observed in the zone adjacent to the Hering canals. These parenchymal cells are regarded as hepatic stem cells or hepatoblasts, which may be involved in hepatocellular carcinogenesis. In the light of recent reports describing nestin-positive parenchymal cells in

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Athukuri, Prazwal, Karina Moreno, Yuhui Yang, et al. "DDEL-06. HEAT-ACTIVATED DOXORUBICIN UPTAKE FACILITATED BY LASER INTERSTITIAL THERMAL THERAPY." Neuro-Oncology 24, Supplement_7 (2022): vii95. http://dx.doi.org/10.1093/neuonc/noac209.352.

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Abstract Although surgery has been shown to provide a survival benefit in patients with glioblastoma multiforme (GBM), tumor location and geometry may restrict maximal resection. Additionally, the margin of resection cavity contains infiltrating tumor cells that result in recurrence and therapy resistance. Laser interstitial thermal therapy (LITT) is a treatment modality that uses thermal energy to destroy tumor cells. LITT is useful for tumors that are not appropriate for conventional surgical resection. Our laboratory has developed a LITT model to study LITT in a genetically engineered mouse

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Leary, Owen, Steven Toms, John Zepecki, Derek Merck, Nikos Tapinos, and Richard Gilbert. "NIMG-21. FROM BEYOND THE MARGIN: HIGH ANGULAR RESOLUTION Q-SPACE MRI MAY DETECT GLIOBLASTOMA TUMOR CELL INVASION INTO BRAIN PARENCHYMA." Neuro-Oncology 21, Supplement_6 (2019): vi166. http://dx.doi.org/10.1093/neuonc/noz175.693.

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Abstract BACKGROUND Invasion of glioblastoma tumor cells beyond the visible margins is hypothesized to mediate tumor spread and recurrence, and thereby affect poor survival. Radiomic biomarkers associated with the extent of tumor infiltration are virtually non-existent. METHODS Seven subjects diagnosed with glioblastoma underwent high resolution “Q-Space” diffusion-weighted MRI sequences (Siemens 3T scanner, 64 gradient directions, b-value=1000s/mm2) during pre-operative MRI workup. For each subject, the largest tumor was manually segmented, and patterns of probabilistic inter-voxel coherence

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Brognaro, E. "P14.19 The inverse paradigm of IDH-wildtype glioblastoma is fundamental to overcome the two causes of resistance and develop novel effective therapies." Neuro-Oncology 21, Supplement_3 (2019): iii70. http://dx.doi.org/10.1093/neuonc/noz126.254.

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Abstract BACKGROUND IDH-wildtype glioblastoma behaves differently from all other solid tumors. This is the reason why after decades of praiseworthy therapeutic efforts, the prognosis remains very poor. Many clues (radiological, clinical, surgical) and recent indirect experimental evidence converge to indicate that the entire brain parenchyma is micro-infiltrated from the very beginning by the founding clone before the primary bulk has started its growth. Therefore, only in IDH-wildtype glioblastoma the malignant (i.e. distantly infiltrating the organ of origin) and deadly (leading cause to pat

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An, Yang, Lan Su, Guole Lin, Han Chen, Yuxin Liu, and Jiaolin Zhou. "The tumor immune microenvironment features and their prognostic value in rectal and sigmoid colon signet-ring cell carcinoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): 3544. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3544.

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3544 Background: Signet-ring cell carcinoma (SRCC) of the rectum and sigmoid colon is a rare and highly malignant challenge in clinical practice. Although high PD-1+CD8+ tumor-infiltrating lymphocyte (TIL) infiltration has been reported as a positive prognostic factor in gastric cancer, pancreatic cancer, etc., its role in colorectal SRCC remains unclear. This study aims to explore the immune landscape of colorectal SRCC and its prognostic implications. Methods: The study included 34 patients with stage II-IV SRCC of the rectum and sigmoid colon. The immune contextures of tumor tissues were ch

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Chopra, Martin, Simone S. Riedel, Viktoria von Krosigk, et al. "In Vivo Bioluminescence Imaging to Study the Contribution of TNF-TNFR Interactions on Immune and Parenchymal Cells to Tumor Cell Progression in a Syngenic Mouse Model." Blood 118, no. 21 (2011): 1110. http://dx.doi.org/10.1182/blood.v118.21.1110.1110.

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Abstract Abstract 1110 The cytokine tumor necrosis factor-α (TNF) has pleiotropic functions both in normal physiology and disease. TNF and its relative lymphotoxin-α (LT) signal by activating two cell surface receptors TNFR1 and TNFR2. TNFR1 is expressed on most cells whereas TNFR2 is mainly expressed in cells of the hematopoietic system. TNF-TNFR interactions were shown to play a major role in graft-versus-leukemia effect and in the immunosurveillance of solid tumors. To study the contribution of TNF-TNFR interactions on tumor cell progression we employed a syngenic B16 melanoma mouse model c

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Chicoine, Michael R., and Daniel L. Silbergeld. "Invading C6 glioma cells maintaining tumorigenicity." Journal of Neurosurgery 83, no. 4 (1995): 665–71. http://dx.doi.org/10.3171/jns.1995.83.4.0665.

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✓ To characterize rat glioma cell invasion, 2 × 106 fluorophore-labeled or transfection-labeled C6 rat glioma cells were implanted in the rat frontal lobe. Eighty percent of the rats implanted formed bulk tumors (3–4 mm in diameter). Two weeks after implantation, fluorescence microscopy revealed single tumor cells in sites over 16 mm from the bulk brain tumor. Tumor cells distant from the bulk tumor remained single without mass formation and invaded primarily along white matter tracts. Two weeks after tumor implantation, three cell lines were created from each brain by disaggregation and initi

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Naleskina, L. A., T. V. Zadvornyi, L. M. Kunska, and N. Y. Lukianova. "Morphological features of invasion of tumor cells of invasive ductal breast cancer." Morphologia 15, no. 3 (2021): 119–24. http://dx.doi.org/10.26641/1997-9665.2021.3.119-124.

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Background. Nowadays, it has been proven that along with the invasion of individual tumor cells, their group migration occurs in the invasive front of the tumor, and this is an important factor in tumor progression. Objective: to determine the features of tumor cell invasion in the invasive front (IF) of invasive ductal breast cancer (BCa) without special specific features (IC NST) and to establish associative links between them and the clinical and pathological characteristics of the disease. Methods. The study was performed on BCa samples (after hematoxylin and eosin stained) from 120 patien

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Kazantseva, Natalia E., Ilona S. Smolkova, Vladimir Babayan, Jarmila Vilčáková, Petr Smolka, and Petr Saha. "Magnetic Nanomaterials for Arterial Embolization and Hyperthermia of Parenchymal Organs Tumors: A Review." Nanomaterials 11, no. 12 (2021): 3402. http://dx.doi.org/10.3390/nano11123402.

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Magnetic hyperthermia (MH), proposed by R. K. Gilchrist in the middle of the last century as local hyperthermia, has nowadays become a recognized method for minimally invasive treatment of oncological diseases in combination with chemotherapy (ChT) and radiotherapy (RT). One type of MH is arterial embolization hyperthermia (AEH), intended for the presurgical treatment of primary inoperable and metastasized solid tumors of parenchymal organs. This method is based on hyperthermia after transcatheter arterial embolization of the tumor’s vascular system with a mixture of magnetic particles and emb

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Ideguchi, Reiko, Kazuto Ashizawa, Saori Akashi, et al. "Malignant Pleural Mesothelioma with Marked Lymphatic Involvement: A Report of Two Autopsy Cases." Case Reports in Oncological Medicine 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/6195898.

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We herein report two cases of malignant pleural mesothelioma with marked lymphangiosis. The patients included a 68-year-old man and a 67-year-old man who both had a history of exposure to asbestos. Computed tomography (CT) on admission showed pleural effusion with pleural thickening. In both cases, a histopathological examination of the pleura confirmed the diagnosis of epithelioid malignant mesothelioma. They received chemotherapy, but the treatment was only palliative. The chest CT assessments during admission revealed marked pleural effusion and mediastinal lymphadenopathy. CT also showed a

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Leprini, Arnaldo, Umberto Valante, Sergio Barocci, et al. "Expression of HLA‐class I molecules in human pancreas." Clinical Transplantation 4, no. 3 (1990): 159–66. http://dx.doi.org/10.1111/j.1399-0012.1990.tb00046.x.

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AbstractIn the present work we have focused our attention on the distribution of HLA‐class I molecules (A, B, C) in human pancreas. To this end, tissue sections from 12 pancreata, obtained from normal cadaver donors, were studied by means of single and double immunoenzymatic stainings with a battery of monoclonal antibodies. The analysis of 10 out of 12 organs demonstrated that: i) endocrine parenchymal cells expressed very low amounts of HLA‐class I antigens as opposed to exocrine parenchymal cells that were stained with different degrees of clear positivity: ii) within the non‐fibroblastic i

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Ryskalin, Larisa, Francesca Biagioni, Paola Lenzi, Alessandro Frati, and Francesco Fornai. "mTOR Modulates Intercellular Signals for Enlargement and Infiltration in Glioblastoma Multiforme." Cancers 12, no. 9 (2020): 2486. http://dx.doi.org/10.3390/cancers12092486.

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Recently, exosomal release has been related to the acquisition of a malignant phenotype in glioblastoma cancer stem cells (GSCs). Remarkably, intriguing reports demonstrate that GSC-derived extracellular vesicles (EVs) contribute to glioblastoma multiforme (GBM) tumorigenesis via multiple pathways by regulating tumor growth, infiltration, and immune invasion. In fact, GSCs release tumor-promoting macrovesicles that can disseminate as paracrine factors to induce phenotypic alterations in glioma-associated parenchymal cells. In this way, GBM can actively recruit different stromal cells, which, i

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Zavyalova, M. V., D. M. Loos, D. S. Pismenny, et al. "Features of lymph node metastasis depending on intratumoral heterogeneity of non-small cell lung cancer in patients with different morphological changes in the bronchial epithelium." Siberian journal of oncology 21, no. 5 (2022): 69–81. http://dx.doi.org/10.21294/1814-4861-2022-21-5-69-81.

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The aim of the study: to examine the relationship between the morphological diversity of non-small cell lung cancer and the frequency of lymph node metastasis in groups of patients with different epithelial conditions in the bronchi adjacent to the tumor. Material and methods. Surgical specimens from 90 patients with non-small cell lung cancer, who were treated in the Thoracoabdominal Department Of The Research Institute Of Oncology Of The Tomsk National Research Medical Center in the period from 2009 to 2017 were studied. The histological type of cancer was determined according to the who cla

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Muthee, Bernadette. "PAEDIATRIC-07 IMAGING OF PINEAL REGION TUMOURS IN CHILDREN." Neuro-Oncology Advances 5, Supplement_4 (2023): iv10. http://dx.doi.org/10.1093/noajnl/vdad121.041.

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Abstract Pineal tumors comprise between 3% and 8% of all pediatric brain tumors. Pineal region tumors can be divided into four categories: Germ cell tumors, pineal cysts, pineal parenchymal tumors, and tumors of the supporting tissues of the pineal gland or adjacent structures (such as pineal gliomas, dermoids, and epidermoids). The most common pineal region tumors are germ cell tumors, most are pure germinomas. Other variants such as nongerminomatous germ cell tumors, mixed germ cell tumors, teratomas, embryonal cell carcinoma, yolk sac tumor, and choriocarcinoma constitute the remainder. Ger

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Werner, Melanie, Stefan Schefczyk, Martin Trippler, et al. "Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3." Viruses 14, no. 2 (2022): 218. http://dx.doi.org/10.3390/v14020218.

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The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses is not well understood. Here, primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells were isolated from liver tissue obtained after tumor resections or liver transplantations. Cells were stimulated with Toll-like receptor 1–9 ligands for 6–24 h. Non-parenchymal liver cells expressed and secreted inflammatory cytokines (IL6, TNF and IL10). Toll-like receptor- and cell type-specific downstream signals included the phosphorylation of

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Kandigian, Savannah E., Sampada Chande, Darin Dolezal, et al. "BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE." Neuro-Oncology Advances 6, Supplement_1 (2024): i7. http://dx.doi.org/10.1093/noajnl/vdae090.020.

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Abstract Leptomeningeal disease (LMD) is a rare form of central nervous system (CNS) metastasis wherein tumor cells invade the cerebrospinal fluid (CSF) filled space that surrounds the brain and spinal cord. For patients with LMD, prognosis is extremely poor even with aggressive treatment. The mechanisms of progression to LMD and the adaptations tumor cells make to survive in this metabolically sparse microenvironment are poorly understood. As 60% of patients with LMD have concurrent or prior parenchymal metastases, our laboratory examined our established murine models of parenchymal metastase

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Cai, Linzhi, Sabrina V. Kirchleitner, Dongxu Zhao, et al. "Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells." International Journal of Molecular Sciences 21, no. 2 (2020): 612. http://dx.doi.org/10.3390/ijms21020612.

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Molecular imaging is essential for diagnosis and treatment planning for glioblastoma patients. Positron emission tomography (PET) with tracers for the detection of the solute carrier family 7 member 5 (SLC7A5; also known as the amino acid transporter light chain L system, LAT1) and for the mitochondrial translocator protein (TSPO) is successfully used to provide additional information on tumor volume and prognosis. The current approaches for TSPO-PET and the visualization of tracer ([18F] Fluoroethyltyrosine, FET) uptake by LAT1 (FET-PET) do not yet exploit the full diagnostic potential of the

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Erra, Stefania, Giorgia Zappaterra, Antonella Lancella, and Antonello Berni. "On a rare case of solitary fibrous tumor in a thyroid gland." GSC Biological and Pharmaceutical Sciences 5, no. 1 (2018): 021–25. https://doi.org/10.5281/zenodo.4305532.

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Solitary fibrous tumor (SFT) represents an ubiquitous soft tissue neoplasia, thought deriving from mesothelial cells. Most of cases are described in respiratory tract, even if many SFT have been reported in abdominal cavity, spermatic cord and some parenchymal organs, such as breast. Solitary fibrous tumor of the thyroid gland (T-SFT) is rarely described, with only 26 cases being reported since 2014 in the international literature [1]. In this manuscript we report a case of solitary fibrous tumor of the thyroid gland in a 67-years-old man occasionally detected on a thyroidectomy sample perform

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Cheng, Jiying, Min Li, Charlotte Flüh, et al. "TMIC-76. HUMANIN RELEASE FROM TUMOR ASSOCIATED MYELOID CELLS PROMOTES GLIOMA CHEMORESISTANCE." Neuro-Oncology 24, Supplement_7 (2022): vii288. http://dx.doi.org/10.1093/neuonc/noac209.1119.

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Abstract Transcriptomic screens of brain tumor (glioblastoma; GBM) parenchymal cells indicated tumor supporting traits of the GBM microenvironment, but largely excluded mitochondrially enriched gene-sets. Here, we show that a mitochondrial transcript of GBM parenchymal cells contributes to therapy resistance. We inspected the non-coding transcriptome of human GBM associated myeloid cells (GAM) and observed an upregulation of the mitochondrial ribosomal subunit MT-RNR2, which contains an open reading frame for the signaling peptide humanin. Immunohistology disclosed that humanin was preponderan

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Kinoshita, Masahiko, Takahito Kawaguchi, Shogo Tanaka, et al. "Application of Indocyanine Green Fluorescence Imaging for Tumor Localization during Robot-Assisted Hepatectomy." Cancers 15, no. 17 (2023): 4205. http://dx.doi.org/10.3390/cancers15174205.

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The efficacy of indocyanine green (ICG) fluorescence imaging for visualizing hepatic tumors in robot-assisted hepatectomy (RAH) should be validated. This study included 30 consecutive patients with 33 collective tumors who underwent RAH. ICG was administered at a dose of 0.5 mg/kg before surgery. ICG fluorescence imaging was performed intraoperatively. In total, 28 patients with a combined total of 31 tumors underwent ICG fluorescence imaging. Further, 26 (84%) tumors were identified on hepatic surfaces prior to hepatic transection. The fluorescence signals of eight tumors were detected on hep

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Chernikova, Sophia, Sheila Tsau, Yuelong Wang, et al. "MODL-25. INTERNAL CAROTID INJECTION MODEL OF BRAIN METASTASIS DESCRIBES LEPTOMENINGEAL DISEASE." Neuro-Oncology 25, Supplement_5 (2023): v304. http://dx.doi.org/10.1093/neuonc/noad179.1176.

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Abstract Leptomeningeal disease (LMD), the most aggressive form of central nervous system (CNS) metastasis in which cancer cells infiltrate leptomeninges, is universally and rapidly fatal due to poor detection and no effective treatment. Treatment of LMD is challenged by the diffuse nature of the disease, low specificity of detection, poor drug penetration into CNS and high neurotoxicity. LMD is a heterogeneous disease: co-existence of leptomeningeal spread and parenchymal brain metastases in not uncommon, and LMD tumors vary in size and may be found at various locations throughout entire neur

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Franses, Joseph Wang, Irun Bhan, Cristina R. Ferrone, Genevieve Marie Boland, and David Tsai Ting. "Spatial transcriptomics characterization of hepatocellular carcinoma using Molecular Cartography." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16110-e16110. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16110.

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e16110 Background: The microenvironment within hepatocellular carcinoma (HCC) tumors is composed of interacting cancer cells, endothelial cells and other stromal cells, and immune cells. The emerging field of spatial transcriptomics enables the measurement of gene expression in specific regions within a tissue sample. This technique retains the spatial context of intact tissue, can provide deep biological insights into cell-cell interactions, tumor microenvironment, and tumor progression. Methods: Resolve Biosciences’ Molecular Cartography platform was used on serial fresh frozen sections obta

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Sathe, Anuja, Aparajita Khan, Ji In Kang, et al. "Abstract 1272: Spatial profiling of human colorectal cancer brain metastasis identifies chromosomal instability with adaptive niche cellular reorganization and reprograming." Cancer Research 84, no. 6_Supplement (2024): 1272. http://dx.doi.org/10.1158/1538-7445.am2024-1272.

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Abstract Brain metastasis in colorectal cancer (mCRC) poses a significant clinical challenge with poor outcomes. Our study, the largest spatial analysis reported to date, aimed to uncover unique cellular and genomic features facilitating metastatic lesion development. Employing spatial transcriptomics on 60 patients' surgical resections, we validated our findings with single-cell RNA sequencing (scRNA-seq), whole-genome sequencing (WGS), and ex vivo functional studies in tumor slice cultures. We obtained spatially distinct gene expression profiles of metastatic tumor cells, tumor microenvironm

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Wang, Hai-Chen, Wen-Xuan Yin, Meng Jiang, et al. "Function and biomedical implications of exosomal microRNAs delivered by parenchymal and nonparenchymal cells in hepatocellular carcinoma." World Journal of Gastroenterology 29, no. 39 (2023): 5435–51. http://dx.doi.org/10.3748/wjg.v29.i39.5435.

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Small extracellular vesicles (exosomes) are important components of the tumor microenvironment. They are small membrane-bound vesicles derived from almost all cell types and play an important role in intercellular communication. Exosomes transmit biological molecules obtained from parent cells, such as proteins, lipids, and nucleic acids, and are involved in cancer development. MicroRNAs (miRNAs), the most abundant contents in exosomes, are selectively packaged into exosomes to carry out their biological functions. Recent studies have revealed that exosome-delivered miRNAs play crucial roles i

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Cacicedo, Maximiliano L., Carolina Medina-Montano, Leonard Kaps, Cinja Kappel, Stephan Gehring, and Matthias Bros. "Role of Liver-Mediated Tolerance in Nanoparticle-Based Tumor Therapy." Cells 9, no. 9 (2020): 1985. http://dx.doi.org/10.3390/cells9091985.

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In the last decades, the use of nanocarriers for immunotherapeutic purposes has gained a lot of attention, especially in the field of tumor therapy. However, most types of nanocarriers accumulate strongly in the liver after systemic application. Due to the default tolerance-promoting role of liver non-parenchymal cells (NPCs), Kupffer cells (KCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), their potential role on the immunological outcome of systemic nano-vaccination approaches for therapy of tumors in the liver and in other organs needs to be considered. Co

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Lim, Eun-Jung, Seungmo Kim, Yoonjee Oh, et al. "Crosstalk between GBM cells and mesenchymal stemlike cells promotes the invasiveness of GBM through the C5a/p38/ZEB1 axis." Neuro-Oncology 22, no. 10 (2020): 1452–62. http://dx.doi.org/10.1093/neuonc/noaa064.

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Abstract Background Mesenchymal stemlike cells (MSLCs) have been detected in many types of cancer including brain tumors and have received attention as stromal cells in the tumor microenvironment. However, the cellular mechanisms underlying their participation in cancer progression remain largely unexplored. The aim of this study was to determine whether MSLCs have a tumorigenic role in brain tumors. Methods To figure out molecular and cellular mechanisms in glioma invasion, we have cultured glioma with MSLCs in a co-culture system. Results Here, we show that MSLCs in human glioblastoma (GBM)

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Jiang, Wulin, Yuchen Yang, Alison R. Mercer-Smith, et al. "Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers." Science Advances 7, no. 24 (2021): eabf1526. http://dx.doi.org/10.1126/sciadv.abf1526.

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Engineered tumor-homing neural stem cells (NSCs) have shown promise in treating cancer. Recently, we transdifferentiated skin fibroblasts into human-induced NSCs (hiNSC) as personalized NSC drug carriers. Here, using a SOX2 and spheroidal culture-based reprogramming strategy, we generated a new hiNSC variant, hiNeuroS, that was genetically distinct from fibroblasts and first-generation hiNSCs and had significantly enhanced tumor-homing and antitumor properties. In vitro, hiNeuroSs demonstrated superior migration to human triple-negative breast cancer (TNBC) cells and in vivo rapidly homed to T

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Buzenkova, A. V., L. A. Tashireva, M. V. Zavyalova, and V. M. Perelmuter. "The features of tumor niche cell composition in invasive breast ductal carcinoma of no special type." Siberian journal of oncology 21, no. 5 (2022): 59–68. http://dx.doi.org/10.21294/1814-4861-2022-21-5-59-68.

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Breast cancer is the most common cancer and the leading cause of cancer death in woman of childbearing age. Tumor progression depends on the character of stromal-parenchymal interactions. Tumor microenvironment exerts a key influence on tumor progression. Tumor niche is an important element of the tumor microenvironment. According to existing ideas, tumor niche consists on immune cells and bone marrow progenitor cells. The present study describes the parameters of tumor niche in invasive breast carcinoma of no special type (IC-NST), associated with lymph node metastases. The purpose of the stu

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Kumar, Raj, Seema Dayal, and Mani Krishna. "Pineal Parenchymal Tumor with Intermediate Differentiation—A Case Report and Review of Literature from Rural India." Indian Journal of Neurosurgery 09, no. 01 (2019): 55–57. http://dx.doi.org/10.1055/s-0039-1698846.

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AbstractPineal gland tumors are rare tumors. According to World Health Organization (WHO) classification (2016) of the central nervous system, pineal parenchymal tumors of intermediate differentiation (PPTID) occupied their position between pineocytoma and pineoblastoma. It is either grade II or III. There are small numbers of reported cases, so its classification is still a matter of controversy. Here, we report a case of a 35-year-old man who presented with complaints of headache, nausea, vomiting, and focal weakness for 1 year. Computed tomography revealed an enhancing mass lesion in the re

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Nikolenko, Dmytro Y., Dmytro M. Boiko, Olexandr A. Shkurupii, and Oksana V. Ovcharenko. "MORPHOMETRIC AND HISTOCHEMICAL CHARACTERISTICS OF THE CRIBRIFORM TYPE OF INTRADUCTAL CARCINOMA OF THE MAMMARY GLAND." Wiadomości Lekarskie 72, no. 5 (2019): 748–52. http://dx.doi.org/10.36740/wlek201905104.

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Introduction: Due to the increasing morbidity and mortality rates from breast cancer, the problem of early, especially morphological diagnosis, continues to be important. The aim of this study to investigate the karyometric and histochemical features of cribriform pattern of parenchyma of intraductal carcinoma of the mammary gland. Materials and methods: Operational and biopsy material was studied in form of serial sections of micropreparations of cribriform type intraductal carcinoma of the mammary gland. Fixation with 10% neutral formalin, paraffin sections are stained with hematoxylin and e

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