Relevant bibliographies by topics / Parkinson's disease; Neuroscience / Dissertations / Theses
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Dissertations / Theses on the topic 'Parkinson's disease; Neuroscience'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Ikuta, Toshikazu. "fMRI study of grammar, Parkinson's disease and dopaminergic medication." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337540.

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Thesis (Ph.D.)--Indiana University, Program of Neuroscience and the Dept. of Linguistics, 2008.<br>Title from PDF t.p. (viewed on Jul 27, 2009). Source: Dissertation Abstracts International, Volume: 69-11, Section: B, page: 6602. Adviser: Laura L. Murray.
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2

Crocker, Stephen J. "Novel therapeutic strategies for the treatment of Parkinson's disease." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9053.

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Parkinson's disease (PD) is a common neurodegenerative disorder associated with the loss of dopamine neurons located in the substantia nigra pars compacta. Current pharmacological approaches for the treatment of PD are confounded by development of abnormal involuntary movements called dyskinesias, and offer limited long-term utility because they do not stop the disease progression. Accordingly, this thesis addressed two primary issues limiting the present treatments of Parkinson's disease: the molecular basis of dopamine receptor-related dyskinesias, and attenuation of dopamine neuron death. A
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3

Biswas, Amitava. "Perioral sensorimotor integration in Parkinson's disease." [Bloomington, Ind.] : Indiana University, 2005. http://wwwlib.umi.com/dissertations/fullcit/3183913.

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4

Alexopoulou, Zoi. "The study of the deubiquitinase USP8 in Parkinson's disease pathogenesis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:47c2941b-5232-4bd0-92fa-e59aac16af7c.

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Parkinson's disease is the second commonest neurodegenerative disease currently treated symptomatically. It is a multifactorial disease involving mechanisms ranging from protein aggregation to mitochondrial dysfunction, oxidative stress and dopamine dysregulation. The levels of &alpha;-synuclein have been causatively linked to the development and progression of Parkinson's disease. Therefore &alpha;-synuclein lowering strategies are valid approaches in Parkinson's disease. Neuropathologically, Lewy Bodies in the vulnerable substantia nigra of Parkinson's disease patients are less ubiquitinated
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5

Little, Simon. "Adaptive deep brain stimulation for Parkinson's disease : closed loop stimulation for Parkinson's." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:5b76616a-7d5e-424e-9c66-5d48b19cae1c.

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Our understanding of the pathophysiology Parkinson’s disease has transformed over the last decade as we have come to appreciate the importance of changes in neuronal firing pattern that occur within the motor network in the dopamine deficient state. These changes in firing pattern, particularly increased synchrony result in oscillations that can be recorded as local field potentials. This thesis concerns itself with the study of beta oscillations which are characteristic of Parkinson’s disease. Firstly, I investigate whether beta oscillations play a pathophysiological role in Parkinson’s disea
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6

Marshall, Victoria Louise. "Clinical and functional imaging correlates in Parkinson's disease." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/7012/.

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Parkinson's disease (PD) is misdiagnosed throughout its disease course for conditions such as essential tremor, drug-induced parkinsonism, vascular pseudo-parkinsonism, Alzheimer's disease and other degenerative parkinsonian diseases. This thesis aims to verify the accuracy of dopaminergic imaging in early and uncertain parkinsonian/tremor disorders through 3 studies. The first is a prospective United Kingdom multicentre assessment of [1231] FP-CIT SPECT use in 190 patients in pre-defined diagnostic categories and with particular focus on clinical features to assess the influence of imaging in
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7

Kabbach, Ghassan. "Interactions of LRRK2 in a Drosophila melanogaster model of Parkinson's disease." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28820.

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Parkinson's disease is the most common movement disorder. A complex neurodegenerative disease, its cause and progressive nature are of unknown roots, making a final cure currently unattainable. Recently, mutations in LRRK2 have been deemed the most common cause of both familial and sporadic forms of Parkinson's disease. Itself a mysterious protein, it harbors pathogenic mutations in all of its complex functional domains. Here, we present a Drosophila melanogaster model of LRRK2 by creating four different human LRRK2 transgenic flies. Wild type LRRK2, and LRRK2 mutants I1122V, Y1699C, and I202
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8

Acosta, Glen Howel G. "Susceptibility of parkinson's disease following mild blast traumatic brain injury." Thesis, Purdue University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1571943.

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<p> Blast injury-induced neurotrauma (BINT) is steadily increasing in prevalence due to escalated terror activity and constitutes the signature injury associated with current military conflicts. BINT produces significant neurological deficiencies and there is a growing concern that the injury may produce long-term consequences that affect the resilience and the performance of soldiers. One of the potential consequences is an increased susceptibility to Parkinson's disease (PD). A vital goal aimed at curtailing the post-deployment long-term consequences of blast injury-induced neurotrauma is to
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9

Song, Linyang 1978. "The role of astroglial HO-1 in the pathogenesis of Parkinson's disease /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98803.

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The mechanisms responsible for the progressive loss of dopaminergic neurons and pathological iron deposition in the substania nigra pars compacta of patients with Parkinson disease (PD) remain incompletely understood. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in the degradation of heme to biliverdin, carbon monoxide, and ferrous iron, is up-regulated in affected PD astroglia and may contribute to aberrant mitochondrial iron sequestration in these cells. To determine whether glial HO-1 hyperexpression is inimical to nearby neuronal constituents, we co-cultured dopaminergic PC12 cells at
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10

Malek, Naveed. "Variation in Parkinson's disease : age, gender, genotype and phenotype correlations in early onset disease." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5602/.

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There is a wide variation in the phenotypic expression, progression rates, therapy response and complications in Parkinson’s disease (PD). The primary research objective in this thesis was to analyse the variation in the 4 domains of phenotypic expression i.e. motor, non-motor, cognitive, and quality of life in a subset of early onset Parkinson’s disease (EOPD) patients from the PRoBaND study, in the United Kingdom. The secondary objective was to explore the factors responsible for this variation or heterogeneity in the clinical characteristics. Linking genotypes with phenotypes, besides evalu
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11

Szewczyk-Krolikowski, Konrad. "Clinical and imaging characteristics of early Parkinson's disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c118f620-19a9-4d0c-bcfc-018e3dd9ff3d.

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<strong>Background</strong>. Pathological processes in Parkinson’s disease (PD) start long before the first symptoms appear and by the time the disease is clinically established the results of neurodegeneration may be irreversible. Efforts to prevent or stem disease progression need to start in early disease and good characterization and new markers of early PD are urgently needed. <strong>Objectives</strong>. This thesis aims to characterize early disease stages in three projects. Firstly, clinical features of PD within 3 years of diagnosis will be explored in an incident cohort of patients a
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Landau, Anne. "A novel neuroprotective role for the Fas molecule in models of Parkinson's disease." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18289.

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Fas (CD95), a member of the tumor necrosis factor receptor (TNF-R) superfamily, has been extensively studied as a death-inducing receptor in immune cells. However Fas is also widely expressed in a number of other cell-types, including in neurons. We have found that defects in the Fas/Fas Ligand system render mice highly susceptible to neural degeneration in models of Parkinson’s disease (PD). Fas-deficient lpr mice develop a dramatic phenotype resembling clinical PD (i.e., characterized by extensive nigrostriatal degeneration accompanied by tremor, hypokinesia, and loss of motor coordination)
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13

Frankel, Dov. "The role of astroglial iron in the pathogenesis of Parkinson's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0019/MQ54222.pdf.

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14

Richards, Christopher David. "Electrophysiology and electrochemistry of substantia nigra neurones in vitro." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259895.

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15

Dashti, Eman. "Role of receptor mediated endocytosis-8, a novel Parkinson's disease gene, in mitochondrial quality control." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121496.

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Over the past two decades, significant understanding of the pathogenesis of Parkinson's disease (PD) has been attributed to the discovery of genes, that when mutated, are responsible for familial forms of PD. Recently a novel autosomal dominant mutation (AD) causing PD was identified in receptor-mediated endocytosis-8 (RME-8). When mutated, symptoms of PD manifest with an onset ~ 70 years of age. RME-8 is a DnaJ domain containing protein that plays an important role in intercellular trafficking and recycling of retrograde cargo. Loss of function of RME-8 disrupts the endosome to Golgi transpor
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16

Smith, Gaynor. "Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson's disease." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/15071/.

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The work presented in herein focuses on the optimisation and use of established animal models to study behavioural, pharmacological, histological and molecular correlates of the debilitating motor side effects of current and future treatments for Parkinson’s disease, namely L-DOPA induced dyskinesia (LID) and graft induced dyskinesia (GID). Chapter 3 optimises the 6-OHDA lesion model in mice, from surgical approaches to behavioural assessment of motor function. The neurotoxin was injected at three different regions along the nigrostriatal tract to produce unique patterns of dopaminergic cell d
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Thiffault, Marie-Christine. "MTTP, L-deprenyl and Parkinson's disease : pharmacological implications of oxidative stress." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34469.

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Excessive free radical formation or antioxidant enzyme deficiency can result in oxidative stress, a mechanism proposed in the toxicity of MPTP and in the etiology of Parkinson's disease (PD). To be effective as a toxin, MPTP must be metabolized by monoamine oxidase-B (MAO-B) to form MPP$ sp+.$ The latter compound leads to the degeneration of the dopaminergic cell bodies of the substantia nigra (SN) and striatal dopamine (DA) depletion that are reminescent of PD. The toxic effects of MPP$ sp+$ are related to the inhibition of NADH dehydrogenase activity in the mitochondrial respiratory chain. T
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18

Brecknell, John Edward. "The rat nigrostriatal system : regeneration and reconstruction." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262821.

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19

Welleford, Andrew. "Autologous Peripheral Nerve Grafts to the Brain for the Treatment of Parkinson's Disease." UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/23.

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Parkinson’s disease (PD) is a disorder of the nervous system that causes problems with movement (motor symptoms) as well as other problems such as mood disorders, cognitive changes, sleep disorders, constipation, pain, and other non-motor symptoms. The severity of PD symptoms worsens over time as the disease progresses, and while there are treatments for the motor and some non-motor symptoms there is no known cure for PD. Thus there is a high demand for therapies to slow the progressive neurodegeneration observed in PD. Two clinical trials at the University of Kentucky College of Medicine (NCT
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20

Torres, Eduardo. "Improving the survival of dopaminergic grafts in a rat model of Parkinson's disease." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55390/.

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The remaining three manuscripts deal with issues directly related to the graft survival and the use of gene therapy and animal models of PD, looking at the dynamics of viral vector gene expression in the pathological brain, an investigation of the two-layer staining obtained on immunohistochemical stained sections, and a re-assessment of the amphetamine induced rotational response of dopamine grafted animals
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21

Duval, Christian 1963. "The clinical relationship between tremor and voluntary motor behavior in patients with Parkinson's disease /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82862.

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Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons of the substantia nigra pars compacta. Symptoms usually include akinesia, bradykinesia, muscle rigidity, postural imbalance and tremor. Despite numerous studies on the physiology and pathophysiology of tremor, its influence on voluntary motor behavior remains unclear. Accordingly, the main objectives of the present thesis were to (a) determine if a clinical relationship existed between tremor and performance of voluntary movements, and (b) characterize the impact of ventrola
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Weiss, Alexander R. "Novel approaches to studying the role of the anterior cingulate cortex in cognition and Parkinson's disease." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:c827764b-af3b-4397-90cc-039f40fab460.

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The motor symptoms of Parkinson's disease (PD) have been linked to the emergence of exaggerated oscillatory activity in the 13 - 35 Hz beta range in recordings of the basal ganglia (BG) thalamocortical circuit of PD patients and animal models. PD patients and animal models also express dopamine-dependent cognitive impairments, implying effects of dopamine loss on the function of the anterior cingulate cortex (ACC). This thesis examines the electrophysiological behavior of the BG thalamocortical circuit in PD and dopamine-normal states during cognitive and motor activity. In vivo recordings in
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23

Podolsky, Eric. "Pharmacological Rescue of Parkinson's Disease Symptoms with Drosophila Larvae." Ohio University Art and Sciences Honors Theses / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1429199460.

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Roberts, Rosalind F. "The role of alpha-synuclein oligomers in Parkinson's disease pathophysiology and biology." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:e13d9429-f2cd-4764-bf8d-d139e71f7711.

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Accumulating evidence links oligomeric species of the protein alpha-synuclein to the neuronal death associated with Parkinson's disease. However, the direct detection of alpha-synuclein oligomers in post-mortem brain has been challenging and this has limited our understanding of their structure, distribution and effects in Parkinson's disease. The work presented in this thesis addresses two aspects of the role of alpha-synuclein oligomers in Parkinson's disease. Firstly, I describe the development of a novel technique, the alpha-synuclein proximity ligation assay (AS-PLA), which specifically d
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Keane, Harriet. "Network pharmacology of the MPP+ cellular model of Parkinson's disease." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:1e18e521-c1a3-4f1b-9572-9c68e0f16c2f.

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Parkinson's disease (PD) is an incurable neurodegenerative motor disorder caused by the inexorable loss of dopamine neurones from the substantia nigra pars compacta. Cell loss is characterised by the perturbation of multiple physiological processes (including mitochondrial function, autophagy and dopamine homeostasis) and much of this pathophysiology can be reproduced in vitro using the mitochondrial toxin MPP+ (1-methyl-4-phenylpyridinium). It was hypothesised that MPP+ toxicity could be modelled using protein-protein interaction networks (PPIN) in order to better understand the interplay of
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Hewitt, Sarah. "Stress-Induced Mitochondrial DJ-1: Role of Parkin, Pink1 and VDAC1." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34341.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by motor symptoms such as tremor, rigidity, akinesia and postural instability. Approximately 90% of the cases are due to unknown causes however a familial inheritance has been shown for about 10% of cases. Loss-of-function mutations in DJ-1 cause early-onset PD. Originally identified as an oncogene, DJ-1 has since had many functions attributed to it but its major role in the cell seems to be oxidative stress handling. We have previously demonstrated that DJ-1 deficiency results in hypersensitivity
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Brodrick, Paige. "A Composite Review of the Proposed Molecular Mechanisms and Genetic Components Underlying Parkinson’s Disease." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/scripps_theses/1337.

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons present in the substantia nigra. The clinical presentation of PD includes tremors, slowed movement (bradykinesia), muscle and limb rigidity, and difficulty with walking and balancing. While many environmental factors can affect the onset and progression of the disease, genetic mutations have a large influence. Of the identified PD-linked genetic mutations, mutations in the leucine-rich repeat kinase 2 (LRRK2) are one of the most common genetic causes of PD. Locate
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Mecconi, Alessandro. "Dopamine replacement therapy reduces beta band burst duration in Parkinson’s disease." Thesis, KTH, Skolan för teknik och hälsa (STH), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215055.

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One of the main characteristics of Parkinson's disease (PD) is an exaggerated oscillatory activity in the beta band (12-30 Hz). This activity has been linked to the rise of symptoms such as bradykinesia and akinesia. Even if dopamine replacement therapy (oral intake of dopamine pro-drug levodopa) reverses these symptoms, the effect of the treatment on the beta band activity has still not been completely understood. Therefore, here the temporal dynamics of beta band activity in human patients affected by PD were characterized with and without levodopa treatment. Local-field-potential (LFP) reco
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Fraraccio, Maria. "Effects of high frequency stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84030.

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Objective. The goal of the present study was to investigate whether high frequency stimulation of the subthalamic nucleus (HFS STN), for the treatment of motor signs and symptoms characteristic of Parkinson disease (PD), has detrimental consequences for cognitive processing. Methods . An extensive battery of neuropsychological tests was administered to 15 PD patients with bilateral implantation of high frequency stimulators of the subthalamic nucleus for the treatment of PD. Patients were tested in two sessions: during one session the stimulator was set to a satisfactory therapeutic lev
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Thevathasan, Arthur Wesley. "Pedunculopontine nucleus stimulation for gait and postural disorders in Parkinson's disease." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b64d5e10-9e22-4c25-8537-5aa4858d77aa.

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The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of midbrain and pons. The PPN in animal models appears topographically organised and functionally related to locomotion and arousal. In Parkinson’s disease, the PPN degenerates and is susceptible to abnormal basal ganglia output. In patients with Parkinson’s disease, low frequency PPN stimulation is proposed to improve gait freezing and postural instability. However, the therapeutic mechanisms, optimal clinical application and precise effects on gait and posture of PPN stimulation are unclear. Here, a topog
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Breger, Ludivine. "Parameters impacting the outcome of cell replacement therapy for Parkinson's disease : a preclinical study." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/49925/.

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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, currently affecting 6.3 million people worldwide. Although it is associated, in the longterm, with severe complications (dyskinesias), L-DOPA remains the gold standardtreatment. An alternative approach to the treatment of PD is the replacement of the lost striatal dopaminergic innervation by transplantation of foetal ventral mesencephalon (VM) dopaminergic precursor cells. Opened trials have provided the proof of concept that intrastriatal VM transplant can survive, integrate and in some cases, restore motor funct
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Medicetty, Satish. "Effect of umbilical cord matrix stem cells on Parkinson’s disease model rats." Diss., Kansas State University, 2005. http://hdl.handle.net/2097/127.

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Doctor of Philosophy<br>Department of Anatomy and Physiology<br>Mark L. Weiss<br>Umbilical cord matrix or Wharton’s Jelly is a mucous connective tissue ensheathing the cord blood vessels and contains mesenchymal-like stem cells. Previously, we have shown that pig umbilical cord matrix stem (pUCMS) cells transplanted into normal rat brain were recovered up to 6 weeks post-transplantation, where a sub-population of pUCMS cells exhibited neuronal morphology and expressed a variety of neuronal markers. Here, approximately 150 pUCMS cells were transplanted into non-immunesuppressed rats that prev
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Bélanger, Catherine. "The Parkinson's disease gene, Parkin, ubiquitinates the endocytic accessory protein Eps15 and regulates endocytosis of the epidermal growth factor receptor /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101705.

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Mutations in the parkin gene are responsible for an early-onset autosomal-recessive form of Parkinson's disease. Parkin is an E3 ubiquitin ligase that acts in the covalent attachment of the small protein ubiquitin to substrate proteins. Although many parkin substrates have been identified, none can fully account for the relatively specific death of the dopaminergic neurons in the substantia nigra that occurs in Parkinson's disease. Using an assay that reconstitutes the ubiquitination reaction completely in vitro, I found that not all disease-associated mutations affected parkin's ligase activi
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Popov, Roman. "Neural Preparation For Step Initiation In Unpredictable Conditions With Age And Parkinson's Disease." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/952.

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Mobility is essential for the independent lifestyle. However, as the US population ages, challenges to mobility start to arise, among them just the aging itself which leads to decreased postural stability, falls and the second most common neurodegenerative disease, that is Parkinson’s disease (PD). We decided to investigate step initiation as it is crucial to mobility: walking is not possible without the first step. Step initiation is impaired in PD. However, the impact of PD on the neural mechanisms of step initiation when some of the step parameters are unpredictable remains unexplored. Cort
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Coxon, Anne. "Exploring mechanisms of change in a pilot randomised trial of a distant delivery mindfulness intervention for people with Parkinson's disease." Thesis, City, University of London, 2018. http://openaccess.city.ac.uk/21605/.

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People with Parkinson's disease report high levels of non-motor symptoms, including anxiety and depression, that are difficult to treat pharmacologically. Mindfulness-based interventions have been shown to be effective in other long-term conditions. This pilot study explored how a mindfulness-based intervention may have had an effect and for whom, with a view to informing future studies. Volunteers were randomised to a remote delivery, eight-week mindfulness cognitive behavioural group therapy intervention (n=40) or wait-list (n=38), and measures for psychological outcomes and putative mediato
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Kosillo, Polina. "Investigating circuits underlying acetylcholine-evoked striatal dopamine release in health and disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:1675813e-0b07-4ede-9094-cdc442679394.

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Dopamine (DA) is a key striatal neuromodulator central to normal functioning of the basal ganglia. Identifying and characterizing circuits governing striatal DA transmission is necessary for understanding DA involvement in adaptive behaviour and pathology. Properties of evoked striatal DA release can be examined using fast-scan cyclic voltammetry at carbon fibre microelectrodes, a technique enabling live monitoring of transmitter release events with sub-millisecond resolution. Experimental work presented in this thesis employed this approach to study regulation of striatal DA by acetylcholine
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Davies, Sian Elizabeth. "Analysis of SMN function in development and Nedd4, a putative modifier of Parkinson's disease, in Drosophila melanogaster." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:7b02d101-aaa4-4658-834d-06a2bcd56136.

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Neurological diseases are devastating illnesses that affect over one billion people worldwide. Drosophila melanogaster provides a genetically tractable system in which to study gene function and the mechanisms of pathogenesis of neurological diseases. In this study I have investigated the function of survival motor neuron (SMN), the causative gene in the neuromuscular disease spinal muscular atrophy (SMA), in growth and differentiation in Drosophila. In addition, I have used the fruit fly to investigate a putative modifier of a previously characterised Drosophila model of Parkinson's disease.
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Stenslik, Mallory J. "The Intranasal Delivery of DNSP-11 and its Effects in Animal Models of Parkinson's Disease." UKnowledge, 2015. https://uknowledge.uky.edu/neurobio_etds/14.

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A major challenge in developing disease altering therapeutics for the treatment of Parkinson’s disease (PD) has been the delivery of compounds across the blood-brain barrier (BBB) to the central nervous system (CNS). While direct surgical infusion has been utilized to deliver compounds to the brain that don’t cross the BBB, issues of poor biodistribution in the CNS due in part to properties of the molecules being delivered and/or infusion device protocols have limited the widespread success of this invasive approach. To avoid the issues of surgically delivering compounds to the CNS, numerous s
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Ahmad, Rufai. "Whole-body coordination when turning on-the-spot in people with stroke and Parkinson's disease : a comparison with healthy controls." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/345342/.

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Turning around to interact with the environment is a common activity of daily living. The location of a target for interaction may be known or unknown prior to turning and the angle of a turn may vary depending on the task to be carried out. Stroke and Parkinson’s disease could compromise coordination of body movement during turning which may pose a risk for instability and subsequent falls. The sequence of onset latency, peak velocity and timing of peak velocity of body segments (eye, head, shoulder, pelvis and foot) while turning on-the-spot were investigated in people with stroke and age-ma
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Janezic, Stephanie. "Molecular and behavioural characterisation of novel α-synuclein BAC transgenic mouse models of Parkinson's disease". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:2f43c3ba-5665-46fe-a6b1-d48c059ba2d5.

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Alterations in the expression levels of α-synuclein (SNCA) provide an important link between familial and sporadic forms of Parkinson’s disease (PD). Multiplications of the human wild-type SNCA locus give rise to early-onset autosomal-dominant forms of PD and elevated α-synuclein expression has been linked to an increased risk for late-onset sporadic PD. The identification of α-synuclein’s physiological and pathophysiological functions has been hindered by a lack of animal models that accurately recapitulate the key disease features. Traditional cDNA-based transgenic models fail to correctly r
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Chen, Kuan-Hua. "Dynamic characteristics of emotion and effects of emotion on driving in normal aging and Parkinson’s disease." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1958.

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Previous studies have shown that the experience of negative emotions is rarer, while experience of positive emotions is more frequent in the elderly, suggesting an overall improvement in emotional well-being as people age. However, most research did not account for the dynamic characteristics of emotions (e.g. peak intensity, latency, duration) and the levels of emotional challenges. In addition, since most previous studies have focused on studying the experience, expression, and psychophysiological
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Merrison-Hort, Robert. "Computational study of the mechanisms underlying oscillation in neuronal locomotor circuits." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3107.

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In this thesis we model two very different movement-related neuronal circuits, both of which produce oscillatory patterns of activity. In one case we study oscillatory activity in the basal ganglia under both normal and Parkinsonian conditions. First, we used a detailed Hodgkin-Huxley type spiking model to investigate the activity patterns that arise when oscillatory cortical input is transmitted to the globus pallidus via the subthalamic nucleus. Our model reproduced a result from rodent studies which shows that two anti-phase oscillatory groups of pallidal neurons appear under Parkinsonian c
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43

Heideman, Simone. "Dynamics of temporal anticipation in perception and action." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:98dde64e-11ea-4516-af8c-5f4707d52907.

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The selective deployment of attention over time optimises our perception and action at the moments when relevant events are expected to happen. Such "temporal orienting" to moments when something is going to happen is especially useful when this information can be combined with predictions about where and what events are likely to occur. A large body of research has already established how temporal predictions dynamically influence our perception and action, but questions remain regarding the neural bases of these attentional mechanisms. In this thesis I present three magnetoencephalography (M
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44

Chaudhry, Zahara Latif. "Examining the impact of caspase activities in PD animal model & differentiated ReNcell VM." Thesis, University of Bedfordshire, 2015. http://hdl.handle.net/10547/601101.

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Parkinson's disease (PD) is a neurodegenerative disorder that is characterised by uncontrollable shaking, muscular rigidity and cognitive impairment, due to low levels of dopamine caused by loss of dopamine containing neurons (DCN). The loss of DCN has been strongly associated with Caspase mediated apoptotic death. At present there are many studies that indicate exercise is beneficial in PD treatment, but there is a lack of research exploring the potential pathways, which exercise can activate and suppress to provide such positive and even negative effects. This study is the first to explore t
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45

Ribeiro, Fernandes Hugo José. "Elucidating the role of GBA in the pathology of Parkinson's disease using patient derived dopaminergic neurons differentiated from induced pluripotent stem cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7027574c-dda4-4752-9010-4c573bd0b2aa.

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Heterozygous mutations in the glucocerebrosidase (GBA) gene represent the most common risk factor for Parkinson’s disease (PD), a disease in which midbrain dopaminergic neurons are preferentially vulnerable. However, the mechanisms underlying this association are still unknown, mostly due to the lack of an appropriate model of study. In this thesis, we aimed at elucidating the role of heterozygous GBA mutations in PD using a specific human induced pluripotent stem cell (hiPSC)-based model of disease. First we developed a protocol for the efficient differentiation of hiPSCs into dopaminergic cu
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46

Chamoun, Mario-Christofer. "An Alzheimer-type cerebrospinal fluid profile in early Parkinson's disease." Thesis, Umeå universitet, Institutionen för psykologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167374.

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In recent years, several studies have discovered traces of Alzheimer's (AD) biomarkers in a large portion of patients with Parkinson's disease (PD), which have been associated with subsequent dementia (PDD). However, the manifestation of AD biomarkers in PD is not fully understood. At present, few studies have investigated how common AD biomarkers are in newly diagnosed and unmedicated patients with PD. This cross-sectional cohort study investigated whether AD biomarkers were present in unmedicated and newly diagnosed patients with PD and patients with PD and overlapping clinical symptoms (cog
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47

Gitchel, George Thomas Jr. "Development of an Accurate Differential Diagnostic Tool for Neurological Movement Disorders Utilizing Eye Movements." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4109.

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Parkinson’s disease and Essential tremor are the two most prevalent movement disorders in the world, but due to overlapping clinical symptoms, accurate differential diagnosis is difficult. As a result, approximately 60% of patients with movement disorders symptoms will have their diagnosis changed at least once before death. By their subjective nature, clinical exams are inherently imprecise, leading to the desire to create an objective, quantifiable test for movement disorders; a test that currently is elusive. Eye movements have been studied for a century, and are widely appreciated to be
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48

Pierson, Johan. "Development of Methods for Protein and Peptide Analysis Applied in Neuroscience Utilizing Mass Spectrometry." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4685.

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49

Aravamuthan, Bhooma Rajagopalan. "Comparing the radiological anatomy, electrophysiology, and behavioral roles of the pedunculopontine and subthalamic nuclei in the normal and parkinsonian brain." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:9a735b39-c1fe-4d5f-b05f-3385f27e6e58.

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and DBS of the pedunculopontine nucleus (PPN) have been shown to be effective surgical therapies for Parkinson’s disease (PD). To better understand the PPN and STN as DBS targets for PD, this research compares the anatomy, electrophysiology, and motor control roles of these nuclei. PPN and STN connections were examined in vivo in human subjects and in the non-human primate using probabilistic diffusion tractography. Both the PPN and STN were connected with each other and with the motor cortex (M1) and basal ganglia. After studying t
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50

Cooper, Jason Fisk. "Aging, Stress, and Pathogenesis of Parkinson's Disease| Studies Using C. elegans." Thesis, Van Andel Research Institute, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10747486.

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<p> Parkinson&rsquo;s disease (PD) is an adult onset neurodegenerative disease that is characterized by deficiencies in movement, cognition, and Lewy body neuropathology within the brain. Motor and cognitive deficiencies progressively worsen through the course of disease concurrent with increasing neuropathology and neurodegeneration. Approximately 10&ndash;15% of PD patients have a family history of PD with a confirmed genetic cause. Presently PD pathogenesis is incompletely understood and there are no treatments capable of halting or reversing this disease. The extended disease-course and ag
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