Academic literature on the topic 'Parkinson´s disease - Physical symptoms'
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Journal articles on the topic "Parkinson´s disease - Physical symptoms"
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Belash, V. O., A. M. Batenina, and A. I. Machulina. "Possibility of osteopathic correction in the complex therapy of patients with Parkinson′s disease." Russian Osteopathic Journal, no. 2 (July 3, 2021): 19–30. http://dx.doi.org/10.32885/2220-0975-2021-2-19-30.
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Introduction. Parkinson′s disease (PD) is a slowly progressive chronic disease and currently all available treatments are aimed at alleviating the symptoms of the disease and improving the quality of patients′ life. The main correction is drug therapy. Taking into account the progressive nature of the disease, the insuffi cient effectiveness of drug therapy, as well as early and frequent complications from drug therapy, the search for new pathogenetic and symptomatic drugs, as well as additional non-drug methods of treatment, is constantly being conducted. A number of authors have also previously demonstrated positive changes in the state of motor functions and regression of some neurological manifestations in PD patients with the use of certain osteopathic correction techniques. The above suggests that osteopathic correction may become one of the new directions in the treatment of PD within the framework of complex therapy.The aim of the study is to substantiate the possibility of the inclusion of osteopathic correction of patients with Parkinson′s disease in complex therapy.Materials and methods. A controlled, randomized prospective study was carried out at the Bakhrushin Brothers City Clinical Hospital and the «Ear, Throat and Nose Clinic» (Moscow) medical center from April 2019 to January 2020. The study included 24 patients aged 60 to 78 years with a diagnosis of Parkinson′s disease stage I–II according to Hoehn and Yahr. Depending on the applied treatment method, the patients were divided by simple randomization into two comparable groups (main and control) of 12 people each. All observed patients received common drug therapy and exercise therapy. Additionally, the patients of the main group underwent osteopathic correction (within 3 months, once every 14 days, a total of 6 sessions were performed). All patients, regardless of the group, underwent an osteopathic examination before and after treatment, with the formulation of an osteopathic conclusion; the quality of life was assessed according to the Medical Outcomes Study 36-Item Short-Form Health Survey, and the impact of motor and non-motor symptoms of PD on the daily activity of patients was assessed using the unifi ed PD assessment scale of the International Society of Movement Disorders (MDS UPDRS).Results. The use of osteopathic correction together with drug therapy in PD patients leads to a statistically signifi cant (p<0,05) improvement in quality of life indicators (vitality scale and physical health scale) and daily physical activity (depression level). There is also a change in the structure of the dominant somatic dysfunctions (SD) in the form of a signifi cant decrease in the number of global SD.Conclusion. To increase the effectiveness of complex therapy for patients with PD, the common drug therapy can be supplemented with osteopathic methods of correction.
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Bohnen, Nicolaas I., Roger L. Albin, Martijn LTM Müller, and Kelvin L. Chou. "Advances in Therapeutic Options for Gait and Balance in Parkinson’s Disease." US Neurology 07, no. 02 (2011): 100. http://dx.doi.org/10.17925/usn.2011.07.02.100.
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There is a need to explore non-dopaminergic approaches to treating balance and gait problems in Parkinsons disease (PD). There is emerging evidence on the role of cholinergic denervation of the pedunculopontine nucleus (PPN) thalamus system and falls in PD. Preliminary clinical trial data suggest that the subgroup of PD patients with frequent falls may be suitable candidates for future cholinergic augmentation clinical trials. Recent controlled clinical trials using methylphenidate have been unable to confirm earlier reports of improved gait in PD. Although progressive deterioration of axial motor symptoms occur with deep brain stimulation of the subthalamic nucleus or globus pallidus interna, new preliminary research suggests that other surgical stimulation sites, such as the PPN, may have a potential benefit on gait and balance impairments in PD. Continuing vigorous exercise and physical fitness should be highly encouraged to patients with PD who are at risk of physical deconditioning and fear of falling, but effective antifall physical therapy interventions remain an unmet clinical need.
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Cotterell, Phil, Debbie Weight, Sharon Joseph, and Paul Joseph. "Complex Parkinson's disease: review and experiences." British Journal of Healthcare Assistants 13, no. 8 (August 2, 2019): 394–400. http://dx.doi.org/10.12968/bjha.2019.13.8.394.
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The rate of Parkinson's disease progression is highly individual. It is important to identify those in the complex stage of the disease. Non-oral therapies may be appropriate for those in the complex stage of the disease who experience motor fluctuations, but there can be reasons for a failure to explore these options. Complex Parkinson's disease is a challenging time for the patient, their carer/s and for Parkinson's specialists. Changes to independence can be difficult to deal with, and the disease has an impact both physically and psychologically. For carers, the impact of Parkinson's can also result in physical and psychological issues, as well as social and financial problems. Consideration often turns to moving into a care environment, dealing with neuropsychiatric issues and challenging unmet need. Dealing with symptoms and problems using a team and a palliative approach is required.
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Cotterell, Phil, Debbie Weight, Sharon Joseph, and Paul Joseph. "Complex Parkinson's disease: review and experiences." British Journal of Neuroscience Nursing 15, no. 3 (June 2, 2019): 140–45. http://dx.doi.org/10.12968/bjnn.2019.15.3.140.
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The rate of Parkinson's disease progression is highly individual. It is important to identify those in the complex stage of the disease. Non-oral therapies may be appropriate for those in the complex stage of the disease who experience motor fluctuations, but there can be reasons for a failure to explore these options. Complex Parkinson's disease is a challenging time for the patient, their carer/s and for Parkinson's specialists. Changes to independence can be difficult to deal with, and the disease has an impact both physically and psychologically. For carers, the impact of Parkinson's can also result in physical and psychological issues as well as social and financial problems. Consideration often turns to moving into a care environment, dealing with neuropsychiatric issues and challenging unmet need. Dealing with symptoms and problems using a team and a palliative approach is required.
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Fiorilli, Giovanni, Federico Quinzi, Andrea Buonsenso, Giusy Casazza, Luigi Manni, Attilio Parisi, Alfonso Di Costanzo, Giuseppe Calcagno, Marzia Soligo, and Alessandra di Cagno. "A Single Session of Whole-Body Electromyostimulation Increases Muscle Strength, Endurance and proNGF in Early Parkinson Patients." International Journal of Environmental Research and Public Health 18, no. 10 (May 20, 2021): 5499. http://dx.doi.org/10.3390/ijerph18105499.
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Parkinson’s disease (PD) patients lead a sedentary lifestyle, being unable or unwilling to exercise conventionally, due to physical and mental limitations. The aim of this study was to assess the acute effects of a single session of whole-body electromyostimulation (WB-EMS) on the physical performances and serum levels of the neurotrophic factors in PD patients. Ten subjects (aged 72.60 ± 6.82) underwent 20 min of physical activity with superimposed WB-EMS and, after four weeks, the same protocol with no WB-EMS. WB-EMS was conducted with intermittent stimulation, with 4 s WB-EMS/4 s rest, at 85 Hz, 350 μs. A physical fitness assessment and blood samples collection, to evaluate neurotrophic factors’ levels (BDNF, FGF21, proNGF, mNGF), were collected before and after the intervention. The RM-ANOVA showed significant improvements in sit-to-stand (p < 0.01), arm curl (p < 0.01), handgrip (p < 0.01) and soda pop test (p < 0.01) after the WB-EMS intervention. Higher proNFG serum levels were observed in the WB-EMS condition compared to the no WB-EMS after 60 min post-intervention (p = 0.0163). The effect of WB-EMS confirmed the electrostimulation ability to modulate the proNGF quantity. The positive impact of the WB-EMS protocol on physical functioning, and eye–hand coordination, makes this intervention a promising strategy to improve motor and non-motor symptoms in PD patients.
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Church, Frank C. "Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease." Biomolecules 11, no. 4 (April 20, 2021): 612. http://dx.doi.org/10.3390/biom11040612.
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Parkinson’s disease (PD) usually presents in older adults and typically has both motor and non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from dopaminergic neuronal cell loss in the mid-brain substantia nigra pars compacta region. Outlined here is an integrative medicine and health strategy that highlights five treatment options for people with Parkinson’s (PwP): rehabilitate, therapy, restorative, maintenance, and surgery. Rehabilitating begins following the diagnosis and throughout any additional treatment processes, especially vis-à-vis consulting with physical, occupational, and/or speech pathology therapist(s). Therapy uses daily administration of either the dopamine precursor levodopa (with carbidopa) or a dopamine agonist, compounds that preserve residual dopamine, and other specific motor/non-motor-related compounds. Restorative uses strenuous aerobic exercise programs that can be neuroprotective. Maintenance uses complementary and alternative medicine substances that potentially support and protect the brain microenvironment. Finally, surgery, including deep brain stimulation, is pursued when PwP fail to respond positively to other treatment options. There is currently no cure for PD. In conclusion, the best strategy for treating PD is to hope to slow disorder progression and strive to achieve stability with neuroprotection. The ultimate goal of any management program is to improve the quality-of-life for a person with Parkinson’s disease.
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Del Felice, Alessandra, Leonora Castiglia, Emanuela Formaggio, Manuela Cattelan, Bruno Scarpa, Paolo Manganotti, Elena Tenconi, and Stefano Masiero. "P73-S TACS and physical therapy for motor and cognitive symptoms in Parkinson’s disease: randomized cross-over trial." Clinical Neurophysiology 130, no. 7 (July 2019): e114. http://dx.doi.org/10.1016/j.clinph.2019.04.601.
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Ferreira, Rodrigo N., Aline S. de Miranda, Natalia P. Rocha, Ana C. Simoes e Silva, Antonio L. Teixeira, and Elizabeth R. da Silva Camargos. "Neurotrophic Factors in Parkinson’s Disease: What Have we Learned from Pre-Clinical and Clinical Studies?" Current Medicinal Chemistry 25, no. 31 (October 16, 2018): 3682–702. http://dx.doi.org/10.2174/0929867325666180313101536.
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Background: Parkinson´s Disease (PD) is a chronic, progressive condition, being the second most common neurodegenerative disorder worldwide. The classical features include: bradykinesia, resting tremor, rigidity and festination. These neurological alterations are probably due to the death of dopaminergic neurons in the Substantia Nigra pars compacta and consequent reduction of dopamine input into the striatum. The decrease of dopamine levels may also be involved in the emergence of non-motor symptoms, including cognitive impairment, anxiety and depression symptoms. Neurotrophic Factors (NF) are proteins that modulate neuronal function, development, and survival. It has been reported that NF might exert a protective role in PD. Objective: We aim to discuss the emerging evidence from pre-clinical and clinical studies regarding the role of NF in PD as well as their potential as promising therapeutic strategies. Methods: We carried out an extensive literature search in PubMed central. Results: Pre-clinical studies using NF to treat PD are divergent probably due to several methodological differences, thus precluding any conclusion. Clinical studies findings obtained with the administration of NF in patients with PD were even more disappointed. On the other hand, pre-clinical and clinical studies generally support that physical activity is a low-cost, non-pharmacologic strategy with good results to treat PD. Conclusion: The use of NF as a treatment for PD is still a promise not incorporated in clinical practice. Methods to deliver NFs, doses and compounds administered, side effects, population characteristics and duration of disease may probably contribute to the unsuccessful results.
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Wasiuk-Zowada, Dagmara, Andrzej Knapik, Justyna Szefler-Derela, Anna Brzęk, and Ewa Krzystanek. "Kinesiophobia in Stroke Patients, Multiple Sclerosis and Parkinson’s Disesase." Diagnostics 11, no. 5 (April 28, 2021): 796. http://dx.doi.org/10.3390/diagnostics11050796.
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Background: Stroke (S), multiple sclerosis (MS), Parkinson’s disease (PD) are chronic neurological diseases that are a challange for public health and represent a real social problem. Physical activity (PA) improves functional performance, reduces various symptoms in PD and MS, in stroke- reduced neurological impairment of patients and provides a chance for independence. One of the main obstacles in successful rehabilitation is patients’ movement passivity. The reason might be the psychological aspects, in particular fear of movement—kinesiophobia. Aim: To determine how many patients with S, MS, and PD suffer from kinsiophobia and what factors influence this process. Methods: Fifty patients after stroke, eighty one MS patients and sixty one PD patients were consecutively recruited from hospital and outpatients clinics. The sociodemographic data, self- assesment of fitness, Visual Analogue Scale (VAS) for pain, Tampa Scale of Kinesiophobia (TSK) and The Modified Baecke Questionnarie for Older Adults for physical activity were collected. A score >37 was considered to indicate a high level of kinesiophobia according to the TSK. Results: High level of kinesiophobia was shown in 66.67% of the subjects. TSK medians in particular illnesses were above the cut-off score and amounted: S—42.50 points; MS—38 points; PD—42.00 points. Regression showed 15% of fluctuation of variance (R2 = 0.1498; p < 0.0001), where regression factor showed: for mobility self-assessment: b = −0.2137 and for the age b = 0.0065. Conclusions: Kinesiophobia among the patients suffering from S, MS and PD concerns most of the subjects. Predictors of kinesiophobia are: limitations connected with functioning and age. The meaning of kinesiophobia in neurological disorders requires further research.
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Jagaran, Keelan, and Moganavelli Singh. "Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases." International Journal of Molecular Sciences 22, no. 16 (August 23, 2021): 9082. http://dx.doi.org/10.3390/ijms22169082.
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Neurodegenerative disorders involve the slow and gradual degeneration of axons and neurons in the central nervous system (CNS), resulting in abnormalities in cellular function and eventual cellular demise. Patients with these disorders succumb to the high medical costs and the disruption of their normal lives. Current therapeutics employed for treating these diseases are deemed palliative. Hence, a treatment strategy that targets the disease’s cause, not just the symptoms exhibited, is desired. The synergistic use of nanomedicine and gene therapy to effectively target the causative mutated gene/s in the CNS disease progression could provide the much-needed impetus in this battle against these diseases. This review focuses on Parkinson’s and Alzheimer’s diseases, the gene/s and proteins responsible for the damage and death of neurons, and the importance of nanomedicine as a potential treatment strategy. Multiple genes were identified in this regard, each presenting with various mutations. Hence, genome-wide sequencing is essential for specific treatment in patients. While a cure is yet to be achieved, genomic studies form the basis for creating a highly efficacious nanotherapeutic that can eradicate these dreaded diseases. Thus, nanomedicine can lead the way in helping millions of people worldwide to eventually lead a better life.
Dissertations / Theses on the topic "Parkinson´s disease - Physical symptoms"
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Nascimento, Carla Manuela Crispim [UNESP]. "Exercício, funcionalidade e distúrbios do sono em pacientes com doença de Parkinson." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/87410.
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A doença de Parkinson (DP) é um processo neurodegenerativo crônico e progressivo que leva a um comprometimento físico refletindo os principais sinais e sintomas da DP. O comprometimento das funções motoras representa um comprometimento da execução das atividades da vida diária. O exercício físico (EF) tem um impacto positivo para os indivíduos com doenças neurodegenerativas, especificamente com DP. Dois estudos foram realizados. O estudo 1 teve como objetivo comparar a mobilidade funcional, distúrbios relatados do sono e os níveis séricos de homocisteína (Hcy) em pacientes com diferentes níveis de atividade física. 41 pacientes entre os estágios um a três da escala de estagiamento clínico de Hohen & Yahr foram distribuídos segundo a participação programas regulares de exercícios físicos. 17 pacientes eram sedentários e 18 mantinham uma prática regular de exercícios físicos. Os distúrbios relatados do sono foram avaliados por meio do Mini Questionário de Sono; as atividades instrumentais foram avaliadas por meio do questionário de Pfeffer; o estagiamento clínico da doença e a condição clínica dos pacientes foram mensurados, respectivamente, pela escala Hoehn e Yahr e pela Unified Parkinson's Disease Rating Scale - UPDRS. A escala de Schwab & England foi aplicada para medir o percentual de funcionalidade. O Mini-Exame do Estado Mental e Teste do Desenho do Relógio foram aplicados para avaliar o funcionamento cognitivo. Os níveis de Hcy foram medidos por meio de técnicas laboratoriais a partir de amostras de sangue. Para a análise dos dados foi realizada uma ANOVA one-way e um teste post hoc de Tuckey para verificar diferenças entre os grupos. A correlação de Pearson e análise de regressão múltipla foram usados para verificar a associação entre diversas variáveis, como a concentração sérica de Hcy...
Parkinson´s disease (PD) is a chronic, progressive and neurodegenerative process. With progression of the disease, there are physical implicantions that reflects in physical symptoms. The motor impairment has a negative impact and compromise the execution of activities daily living. Physical exercise (PE) has a positive impact for individuals with neurodegenerative disabilities, specifically in PD. Two studies were conducted. The study 1 aimed to compare the functional mobility, sleep reported disorders and levels of homocysteine (Hcy) in PD patients with different levels of physical activity. Forty-one patients between stages one to three of Hohen & Yahr scale were distributed by participation in a program of regular physical exercises. 17 patients were sedentary and 18 had a regular practice of physical exercises. Sleep reported disorders were evaluated by Mini-Sleep Questionnaire; Instrumental activities were evaluated by Pfeffer Questionnaire; Clinical stages and motor condition of patients were respectively measured by the Hoehn and Yahr scale and by the Unified Parkinson’s Disease Rating Scale – UPDRS. Schwab and England scale were applied to measure the daily functionality. The Mini-Mental State Examination (MMSE) and the Clock Drawing Test (CDT) were applied to evaluate the cognitive background. Levels of Hcy were measured by collection of blood and laboratorial techniques. The one-way ANOVA and Tuckey’s post hoc was applied to verify differences between groups. Pearson correlation and stepwise multiple regression analysis were used to consider the association between several variables, as serum concentration of Hcy, motor condition, cognitive status, and L-dopa dosages. Patients who practice PE presented significant less sleep reported disturbances and lower levels of Hcy when compared... (Complete abstract click electronic access below)
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MALAK, ANA LARA SOARES BLUM. "DEPRESSION SYMPTOMS IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT IN PARKINSON S DISEASE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2016. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=27733@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
A Doença de Parkinson (DP) é caracterizada pela ocorrência de sintomas motores. No entanto, sintomas não motores, como depressão e comprometimento cognitivo, são comuns e não devem ser ignorados. A presente dissertação investigou a frequência dos sintomas depressivos e seus efeitos na cognição de indivíduos com DP com declínio cognitivo leve (DCL). Foram avaliados 48 sujeitos com DP e 44 controles (GC), com idade entre 50 e 80 anos e escolaridade superior a 4 anos, todos com DCL e sem diagnóstico de depressão. Os participantes foram submetidos à avaliação clínica com neurologista, seguida de avaliação neuropsicológica. Os sintomas depressivos foram mensurados com o uso do Inventário de Depressão de Beck. Dificuldade no trabalho, fadiga e distúrbio do sono foram sintomas mais frequentes no grupo DP, enquanto o grupo sem DP apresentou além de distúrbios do sono, sintomas de irritabilidade e diminuição da libido. A presença destes sintomas mostrou-se associada a prejuízo da atenção combinado a déficit de memória episódica, especialmente em tarefas de reconhecimento de novas informações verbais. Os sintomas depressivos prevalentes nos Parkinsonianos com DCL podem ser atribuídos à DP, dificultando o diagnóstico diferencial entre essas condições.
Parkinson s Disease (PD) is characterized by the occurrence of motor symptoms. However, non motor symptoms such as depression and cognitive impairment are common and should not be ignored. This thesis investigated the frequency of depressive symptoms and their effect on cognition in individuals with PD with mild cognitive impairment (MCI). Forty eight subjects with PD and 44 controls (CG), aged between 50 and 80 years and higher education to four years, all with MCI and undiagnosed depression were studied. The participants underwent clinical evaluation with a neurologist, followed by neuropsychological assessment. Depressive symptoms were measured using the Beck Depression Inventory. Difficulty in work, fatigue and sleep disorders were more frequent symptoms in PD group, whereas the group without PD presented beyond sleep disorders, symptoms of irritability, and decreased libido. The presence of these symptoms was found to be associated with loss of attention combined to episodic memory deficits, especially in recognition tasks of new verbal information. The prevalent depressive symptoms in parkinsonians with MCI can be attributed to PD, complicating the differential diagnosis between these conditions.
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Nascimento, Carla Manuela Crispim. "Exercício, funcionalidade e distúrbios do sono em pacientes com doença de Parkinson /." Rio Claro, 2009. http://hdl.handle.net/11449/87410.
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Orientador: Florindo StellaBanca: Hanna Karen Antunes
Banca: Lilian Teresa Bucken Gobbi
Resumo: A doença de Parkinson (DP) é um processo neurodegenerativo crônico e progressivo que leva a um comprometimento físico refletindo os principais sinais e sintomas da DP. O comprometimento das funções motoras representa um comprometimento da execução das atividades da vida diária. O exercício físico (EF) tem um impacto positivo para os indivíduos com doenças neurodegenerativas, especificamente com DP. Dois estudos foram realizados. O estudo 1 teve como objetivo comparar a mobilidade funcional, distúrbios relatados do sono e os níveis séricos de homocisteína (Hcy) em pacientes com diferentes níveis de atividade física. 41 pacientes entre os estágios um a três da escala de estagiamento clínico de Hohen & Yahr foram distribuídos segundo a participação programas regulares de exercícios físicos. 17 pacientes eram sedentários e 18 mantinham uma prática regular de exercícios físicos. Os distúrbios relatados do sono foram avaliados por meio do Mini Questionário de Sono; as atividades instrumentais foram avaliadas por meio do questionário de Pfeffer; o estagiamento clínico da doença e a condição clínica dos pacientes foram mensurados, respectivamente, pela escala Hoehn e Yahr e pela Unified Parkinson's Disease Rating Scale - UPDRS. A escala de Schwab & England foi aplicada para medir o percentual de funcionalidade. O Mini-Exame do Estado Mental e Teste do Desenho do Relógio foram aplicados para avaliar o funcionamento cognitivo. Os níveis de Hcy foram medidos por meio de técnicas laboratoriais a partir de amostras de sangue. Para a análise dos dados foi realizada uma ANOVA one-way e um teste post hoc de Tuckey para verificar diferenças entre os grupos. A correlação de Pearson e análise de regressão múltipla foram usados para verificar a associação entre diversas variáveis, como a concentração sérica de Hcy... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Parkinson's disease (PD) is a chronic, progressive and neurodegenerative process. With progression of the disease, there are physical implicantions that reflects in physical symptoms. The motor impairment has a negative impact and compromise the execution of activities daily living. Physical exercise (PE) has a positive impact for individuals with neurodegenerative disabilities, specifically in PD. Two studies were conducted. The study 1 aimed to compare the functional mobility, sleep reported disorders and levels of homocysteine (Hcy) in PD patients with different levels of physical activity. Forty-one patients between stages one to three of Hohen & Yahr scale were distributed by participation in a program of regular physical exercises. 17 patients were sedentary and 18 had a regular practice of physical exercises. Sleep reported disorders were evaluated by Mini-Sleep Questionnaire; Instrumental activities were evaluated by Pfeffer Questionnaire; Clinical stages and motor condition of patients were respectively measured by the Hoehn and Yahr scale and by the Unified Parkinson's Disease Rating Scale - UPDRS. Schwab and England scale were applied to measure the daily functionality. The Mini-Mental State Examination (MMSE) and the Clock Drawing Test (CDT) were applied to evaluate the cognitive background. Levels of Hcy were measured by collection of blood and laboratorial techniques. The one-way ANOVA and Tuckey's post hoc was applied to verify differences between groups. Pearson correlation and stepwise multiple regression analysis were used to consider the association between several variables, as serum concentration of Hcy, motor condition, cognitive status, and L-dopa dosages. Patients who practice PE presented significant less sleep reported disturbances and lower levels of Hcy when compared... (Complete abstract click electronic access below)
Mestre
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Perissinotto, Maria Carolina Ramos 1979. "Efeitos da eletroestimulação do nervo tibial posterior nos sintomas do trato urinário inferior e impacto na qualidade de vida em pacientes com doença de Parkinson = dados preliminares = Posterior tibial nerve stimulation in the treatment of lower urinary tract symptoms and its impact on quality of life in patients with parkinson¿s disease: randomized pilot study." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308512.
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Orientador: Carlos Arturo Levi D'AnconaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-22T09:57:34Z (GMT). No. of bitstreams: 1 Perissinotto_MariaCarolinaRamos_D.pdf: 1870557 bytes, checksum: a3f8aae56bf22e41993fdf4017268274 (MD5) Previous issue date: 2013
Resumo: Introdução: A doença de Parkinson é uma doença neurológica degenerativa de causa desconhecida que leva a alterações motoras em decorrência da diminuição dos neurotransmissores de dopamina na substância nigraestriatal. Distúrbios miccionais acometem de 37% a 70% dos pacientes com esta doença. A eletroestimulação do nervo tibial posterior é uma opção no tratamento dos sintomas do trato urinário inferior. Objetivo: Avaliar a eficácia da referida eletroestimulação na sintomatologia do trato urinário inferior em pacientes com doença de Parkinson. Métodos: A metodologia utilizada foi o estudo controlado randomizado, pela qual foram 96 pacientes com diagnóstico de doença de Parkinson com queixas de sintomas do trato urinário inferior, os quais foram alocados em dois grupos: grupo tratamento e grupo sham. Todos os pacientes foram avaliados através de escalas específicas para a doença de Parkinson, como a Unified Parkinson's Diseases Rating Scale, nos quais preencheram os questionários de qualidade de vida, de incontinência urinária e de bexiga hiperativa, através dos quais foi realizado o estudo urodinâmico. Todas as avaliações foram realizadas pré e pós-tratamento e a técnica utilizada foi a eletroestimulação do nervo tibial posterior durante dez sessões, duas vezes por semana com duração de 30 minutos cada sessão. O grupo de tratamento realizou esta eletroestimulação e o outro grupo, o procedimento sham. Resultados: Os resultados obtidos ao final do tratamento foi que o grupo de tratamento relatou melhora significativa nos sintomas urinários de urgência e noctúria em comparação ao grupo sham. Urgência (p=0,0047), entre os grupos (100,0% grupo de tratamento, 12,5% grupo sham) e noctúria no grupo de tratamento entre os tempos pré e pós (p=0,0156) (4,0 pré - 2,0 pós). Na análise da qualidade de vida, ocorreu uma melhora significativa no score total do questionário International Consultation on Incontinence Questionnaire no grupo de tratamento entre os tempos pré e pós (p=0,0191) (7,0 pré - 4,0 pós), e no questionário Overactive Bladder Questionnaire no mesmo grupo entre os tempos (p=0,0144) (29,0 pré - 21,5 pós). No estudo urodinâmico, houve melhora significativa no grupo de tratamento entre o tempo pré e pós no primeiro desejo (mediana 150 pré -185 ml pós) (p=0.0056) e volume urgência (mediana 200 pré -285 ml pós) (p= 0.0014). Conclusão: O tratamento com a eletroestimulação do nervo tibial posterior se mostrou uma técnica capaz de melhoras na sintomatologia do trato urinário inferior em pacientes com doença de Parkinson, tais como a redução da urgência e da noctúria, proporcionando, assim, melhora na qualidade de vida desses pacientes. Novos estudos são necessários para aprofundar a eficácia desta técnica em pacientes com doença de Parkinson
Abstract: Introduction: Parkinson's disease is a neurologic disorder caused by neurodegeneration of the nigrostriatal dopaminergic. Lower urinary tract symptoms, are non-motor symptoms that occur in 37% to 70% of patients throughout the course of the disease and negatively affect the Quality of Life of these patients. Aims: Evaluate the efficacy of transcutaneous posterior tibial nerve stimulation on treatment of lower urinary tract symptoms in patients with Parkinson's disease. Methods: Randomized controlled trial, twenty three patients with a diagnosis of parkinson's disease and lower urinary tract symptoms, were randomized in two groups: PNTS group (GI) and group sham (GII). Evaluation included, urinary symptoms, Unified Parkinson's Diseases Rating Scale, International Consultation on Incontinence Questionnaire, Overactive Bladder Questionnaire questionnaire and the urodynamic study, all evaluation were performed pre and post PNTS. GI intervention consisted on PNTS and GII received a sham treatment with effective stimulation. Results: At the end of the treatment the GI present's significant improvement in storage and voiding symptoms than GII. There were significant differences on the symptoms of urgency (p=0.0047) between group (100.0% GI, 12.5% GII). In nocturia occurs an improvement pre and post PNTS in GI (p=0.0156) (4.0 pre - 2.0 post). Quality of life analyses there were significant differences on questionnaire, International Consultation on Incontinence Questionnaire, GI pre and post PNTS (p=0.0191) (7.0 pre - 4.0 post) and Overactive Bladder Questionnaire, GI pre and post PNTS (p=0.0144) (29.0 pre - 21.5 post). There were statistical difference in the urodynamic study pre and post PNTS in group I in volume stronge desire (median 150 pre -185ml post) (p=0.0056) and volume urgency (Median 200 pre-285 ml post) (p= 0.0014). Conclusion: PNTS is an option in the treatment of Lower urinary tract symptoms in patients with diagnosis of parkinson's disease, contributing to reduce urgency and nocturia and improving Quality of life score. This pilot study shows a good response in treat patients with parkinson's disease and Lower urinary tract symptoms, further study should be perform to provide evidence of the potential therapeutic effects
Doutorado
Fisiopatologia Cirúrgica
Doutora em Ciências
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Lopes, Andrei Guilherme [UNESP]. "Efeitos do treinamento físico sobre o nível de atividade física, capacidade funcional e comprometimento motor na doença de parkinson." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/87437.
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lopes_ag_me_rcla.pdf: 803194 bytes, checksum: 01d9e06cc26d18b52a0e6f56884f5916 (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O objetivo do presente estudo foi analisar os efeitos de um programa de atividades físicas generalizadas e sistematizadas, especificamente delineado para parkinsonianos, sobre o nível de atividade física, comprometimento motor e capacidade funcional (flexibilidade, coordenação, força, agilidade, equilíbrio dinâmico, resistência aeróbia e habilidade de andar), em pessoas com Doença de Parkinson (DP). Participaram do estudo 22 idosos com DP, idade média de 66 anos e moradores do município de Rio Claro e região, que foram divididos em Grupo Treinamento (GT; n=11) e Grupo Controle (GC; n=11). Foram encontradas interações significativas (p,0,05) nas variáveis nível de atividade física, comprometimento motor e componentes de capacidade funcional, exceto coordenação motora manual, e resistência aeróbia/ habilidade de andar. Conclui-se que: a) o protocolo de treinamento utilizado é eficiente para aumentar nível de atividade física, melhorar a capacidade funcional e diminuir o comprometimento motor. Tais benefícios contrapõem-se aos efeitos deletérios do envelhecimento e da DP e, contrariamente a não participação agrava tais efeitos. Para amplificar os benefícios sugere-se: a) aumentar a freqüência das sessões com atividades de flexibilidade; b) incorporar mais atividades que demandem coordenação motora manual e; c) incorporar atividades de andar, seja num programa supervisionado ou como parte das ou relacionadas com AVD dos parkinsonianos .
The objective of this study was to analyze the effects of a physical activities program, designed for parkinsonians specifically, on the physical activity level, motor impairment and the functional capacity (flexibility, coordination, strength, agility, dynamic balance, endurance and walk ability) on older people with Parkinson`s disease (PD). Twenty-two older people with PD, mean age of 66 yearold; living at Rio Claro city and region, who were assigned into Training Group (TG; n=11) and Control Group (CG; n=11). Significant statistical interactions were found on physical activity level, motor impairment level and the functional capacity components variables, with exception of manual motor coordination and aerobic endurance/walk hability. It was concluded that: a) the training protocol applied was efficient in order to increase physical activity level; to improve functional capacity and; to reduce motor impairment. Such benefits counteract the deleterious effects PD associated with aging and a non-attendance to the training worsens such effects, conversely. If its to amplify the benefits, it is suggested: a) to increase the frequency of the training sessions on flexibility; b) to incorporate more activities which demand manual motor coordination and; c) to add walking. Such improvements can be fostered, either as part of a supervised program or as part of daily living activities of the parkinsonians.
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CHIN-HUICHEN and 金惠珍. "The Neuropsychiatric Symptoms and Quality of Life in Patients With Parkinson`s Disease." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/80035573052771042464.
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碩士國防醫學院
護理研究所
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The purpose of this study was to examine the relationship between neuropsychiatric symptoms and quality of life in patients with Parkinson`s disease. Method: Ninety patients diagnosed by two neurologists at a teaching hospital in north Taiwan were recruited. The clinic examinations and interview were carried out. Study instruments including Beck Depression Inventory (BDI-II),The Parkinson’s Disease Questionnaire-39 Item (PDQ-39),Mini Mental State Examination(MMSE) ,and Unified Parkinson`s Disease Rating Scale(UPDRS）were used to evaluate patients . The data were analyzed by using frequency, percentage, average, standard deviation, independent-sample t test, Pearson’s product moment correlation, and mutiple regression. The SPSS for Window 13.0 was used. Result: The average BDI was 13.32 (SD =8.43). Sex（t=-3.97,p＜.01,education level(F=2.63, p＜.05),using antidepression medication（t=-2.68,p＜.01）,duration(r=.21, p<.05),MMSE(r=-.30,p<.01), Hoehen and Yahr stage(r=.38,p<.05),UPDRS total score(r=.42,p<.01) were significantly associated with depression. PDQ-39, sex, and education level explain 51.5% of the variance of depression（F=30.43, p＜.001）.The mean of PDQ-39 was 26.26 (SD = 16.67). Age(r=.30, p<.05),MMSE(r=-.57, p<.01), Hoehen and Yahr stage(r=.79, p<.01),BDI score (r=.62, p<.01), and UPDRS total score(r=.90, p<.01) were related to PDQ-39. UPDRS total score, and depression explained 78.3% of the variance of quality of life. Depression is one of quality of life predictors.Conclusion: Parkinson`s disease influence not only patients’physiological status, but also psychological mood. The lower the depression the better the quality of life in patients with Parkinson`s disease.
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Gajula, Balija Madhu Babu. "Towards Uncovering the Role of Pre-fibrillar Oligomers of á-Synuclein in the Pathogenesis of Parkinson's Disease." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B519-4.
Full textBook chapters on the topic "Parkinson´s disease - Physical symptoms"
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GRACIES, J., W. TSE, M. LUGASSY, and J. FRANK. "Physical therapy in Parkinson's disease." In Parkinson's Disease and Related Disorders, Part II, 1–16. Elsevier, 2007. http://dx.doi.org/10.1016/s0072-9752(07)84030-9.
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Rubenstein, Richard. "The Link Between Traumatic Brain Injury and Neurodegenerative Diseases." In Neurotrauma, edited by John K. Yue, Ethan A. Winkler, Hansen Deng, Amy J. Markowitz, Kevin K. W. Wang, and Geoffrey T. Manley, 165–80. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190279431.003.0016.
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Traumatic brain injury (TBI) is a physical impact to the head usually in the form of a single or repetitive closed head injury. TBI is classified as mild, moderate, and severe based on neurological assessment which may include neuroimaging. TBI is a heterogeneous injury, with most cases being mild and difficult to diagnose. TBI can be separated into a primary injury and secondary injury. Primary injury is a result of the physical head impact, whereas secondary injury can occur as long as months to years later and is the result of pathophysiological changes in the central nervous system. TBI is considered a risk factor for chronic neurodegenerative diseases (Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy) in spite of each disease having unique clinical symptoms, pathologies, and specific discriminating proteins. To date, little is known about the pathological changes responsible for linking TBI to neurodegenerative diseases.
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Liang, Yu, Dalei Wu, Dakila Ledesma, Zibin Guo, Erkan Kaplanoglu, and Anthony Skjellum. "VIGOR: A Versatile, Individualized and Generative ORchestrator to Motivate the Movement of the People with Limited Mobility." In Smart and Pervasive Healthcare [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96025.
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Physical inactivity is a major national concern, particularly among individuals with chronic conditions and/or disabilities. There is an urgent need to devise practical and innovative fitness methods, designed and grounded in physical, psychological and social considerations that will effectively promote physical fitness participation among individuals of all age groups with chronic health condition(s) and/or disabilities. This research is dedicated to achieving Versatile, Individualized, and Generative ORchestrator (VIGOR) to motivate the movement of the people with limited mobility. Tai-Chi is a traditional mind–body wellness and healing art, and its clinical benefits have been well documented. This work presents a Tai-Chi based VIGOR under development. Through the use of Helping, Pushing and Coaching (HPC) functions by following Tai-Chi kinematics, the VIGOR system is designed to make engagement in physical activity an affordable, individually engaging, and enjoyable experience for individuals who live with mobility due to disease or injury. VIGOR consists of the following major modules: (1) seamless human-machine interaction based on the acquisition, transmission, and reconstruction of 4D data (XYZ plus somatosensory) using affordable I/O instruments such as Kinect, Sensor and Tactile actuator, and active-orthosis/exoskeleton; (2) processing and normalization of kinetic data; (3) Identification and grading of kinetics in real time; (4) adaptive virtual limb generation and its reconstruction on virtual reality (VR) or active-orthosis/exoskeleton; and (5) individualized physical activity choreography (i.e., creative movement design). Aiming at developing a deep-learning-enabled rehab and fitness modality through infusing the domain knowledge (physical therapy, medical anthropology, psychology, electrical engineering, bio-mechanics, and athletic aesthetics) into deep neural network, this work is transformative in that the technology can be applied to the broad research areas of intelligent systems, human-computer interaction, and cyber-physical human systems. The resulting VIGOR has significant potentials as both rehabilitative and fitness modalities and can be adapted to other movement modalities and chronic medical conditions (e.g., yoga and balance exercise; fibromyalgia, multiple sclerosis, Parkinson disease).
Conference papers on the topic "Parkinson´s disease - Physical symptoms"
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Hena, Kausar, Manchanda Rahul, Lekhi Anshika, Chitra C. H. Sravani, and Jain Nidhi. "Granulosa cell tumour of ovary in a benign looking adnexal mass: A rare occurrence and its management." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685402.
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Granulosa cell tumours are sex cord stromal tumours of the ovary which accounts for 1-2% of all ovarian malignancies. We present a case of a 22 yrs old unmarried girl with chief complaints of dysmenorrhoea for last 4 months. There were no other symptoms and her general physical examination revealed no abnormality. Ultrasonography showed a simple ovarian cyst of 7 x 8 cm in right adnexa with normal Doppler flow and no ascites. Her tumour markers were negative. Per-operative uterus and left sided ovary and upper abdomen was normal. Right ovary showed a simple unilocular cyst of around 8 x 8 cm and right ovarian cystectomy done. Surprisingly histopathological examination of cyst wall revealed granulosa cell tumour. Immunohistochemical staining was found to be positive especially with inhibin. Staging laparoscopy with peritoneal wash, multiple peritoneal biopsy with right sided salpingo-oopherectomy, left sided ovarian biopsy and dilatation and curettage was done. Cytological and histopathlogical examination were found to be normal. Post operatively patient received chemotherapy because cyst wall was ruptured per-operatively and patient is doing fine and disease free till now.
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Proctor, Cecile J., Danie A. Beaulieu, Anthony J. Reiman, and Lisa A. Best. "LIVING WELL AFTER CANCER: THE IMPACT OF SOCIAL SUPPORT AND PRODUCTIVE LEISURE." In International Psychological Applications Conference and Trends. inScience Press, 2021. http://dx.doi.org/10.36315/2021inpact029.
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"It is now recognized that the ""cancer experience"" extends beyond diagnosis, treatment, and end-of-life care. Relative to individuals who have not faced a cancer diagnosis, cancer survivors report increased mental health concerns and lowered physical and psychological well-being (Langeveld et al., 2004). Health-related quality of life encompasses overall physical (e.g., energy, fatigue, pain, etc.) and psychological functioning (e.g., emotional well-being, etc.), as well as general health perceptions (Hays & Morales, 2001). Nayak and colleagues (2017) reported that 82.3% of cancer patients had below-average quality of life scores, with the lowest scores found in the general, physical, and psychological well-being domains. Research suggests that various positive lifestyle variables, including social connectedness, leisure activity, and mindfulness practices are associated with increased quality of life in cancer patients (Courtens et al., 1996; Fangel et al., 2013; Garland et al., 2017). In this study, 350 cancer survivors completed an online questionnaire package that included a detailed demographic questionnaire with medical and online support and leisure activity questions. Additional measures were included to assess quality of life (QLQ-C30; Aaronson et al., 1993), social connectedness (Social and Emotional Loneliness Scale for Adults, SELSA-S; DiTommaso et al., 2004), and mindfulness (Adolescent and Adult Mindfulness Scale, AAMS; Droutman et al., 2018). Results show that increased QOL is predicted by increased medical support, lower family loneliness, self-acceptance, and engaging in a variety of leisure activities. Encouraging family support, including the patient in the decision-making process, encouraging a variety of physically possible leisure activities, and normalizing negative emotions surrounding diagnosis and disease symptoms are all ways that overall QoL can be improved."