Log in

Relevant bibliographies by topics / Partial cell fusion / Journal articles

To see the other types of publications on this topic, follow the link: Partial cell fusion.

Journal articles on the topic 'Partial cell fusion'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Partial cell fusion.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Baldwin, Brenda R., Chen-Ou Zhang, and Susan Keay. "Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH." Microbiology 81, no. 1 (2000): 27–35. http://dx.doi.org/10.1099/0022-1317-81-1-27.

Full text

Abstract:

A cDNA clone encoding a partial putative human cytomegalovirus (HCMV) gH fusion receptor (CMVFR) was previously identified. In this report, the cDNA sequence of CMVFR was determined and the role of this CMVFR in HCMV/cell fusion was confirmed by rendering fusion-incompetent MOLT-4 cells susceptible to fusion following transfection with receptor cDNA. Blocking experiments using recombinant gH or either of two MAbs (against recombinant gH or purified viral gH:gL) provided additional evidence for the role of gH binding to this protein in virus fusion. An HCMV-binding domain of 12 aa in the middle

APA, Harvard, Vancouver, ISO, and other styles

2

Aydemirli, Mehtap Derya, Jaap D. H. van Eendenburg, Tom van Wezel, et al. "Targeting EML4-ALK gene fusion variant 3 in thyroid cancer." Endocrine-Related Cancer 28, no. 6 (2021): 377–89. http://dx.doi.org/10.1530/erc-20-0436.

Full text

Abstract:

Finding targetable gene fusions can expand the limited treatment options in radioactive iodine-refractory (RAI-r) thyroid cancer. To that end, we established a novel cell line ‘JVE404’ derived from an advanced RAI-r papillary thyroid cancer (PTC) patient, harboring an EML4-ALK gene fusion variant 3 (v3). Different EML4-ALK gene fusions can have different clinical repercussions. JVE404 cells were evaluated for cell viability and cell signaling in response to ALK inhibitors crizotinib, ceritinib and lorlatinib, in parallel to the patient’s treatment. He received, after first-line lenvatinib, cri

APA, Harvard, Vancouver, ISO, and other styles

3

Peng, Hong, Ning Kang, Jun Xu, Patric K. Stanton, and Jian Kang. "Two Distinct Modes of Exocytotic Fusion Pore Expansion in Large Astrocytic Vesicles." Journal of Biological Chemistry 288, no. 23 (2013): 16872–81. http://dx.doi.org/10.1074/jbc.m113.468231.

Full text

Abstract:

Formation of the fusion pore is a central question for regulated exocytosis by which secretory cells release neurotransmitters or hormones. Here, by dynamically monitoring exocytosis of large vesicles (2–7 μm) in astrocytes with two-photon microscopy imaging, we found that the exocytotic fusion pore was generated from the SNARE-dependent fusion at a ring shape of the docked plasma-vesicular membrane and the movement of a fusion-produced membrane fragment. We observed two modes of fragment movements, 1) a shift fragment that shifted to expand the fusion pore and 2) a fall-in fragment that fell

APA, Harvard, Vancouver, ISO, and other styles

4

Elia, L., and L. Marsh. "Role of the ABC transporter Ste6 in cell fusion during yeast conjugation." Journal of Cell Biology 135, no. 3 (1996): 741–51. http://dx.doi.org/10.1083/jcb.135.3.741.

Full text

Abstract:

Though early stages of yeast conjugation are well-mimicked by treatment with pheromones, the final degradation of the cell wall and membrane fusion of mating that leads to cytoplasmic mixing may require separate signals. Mutations that blocked cell fusion during mating in Saccharomyces cerevisiae were identified in a multipartite screen. The three tightest mutations proved to be partial-function alleles of the ABC-transporter gene STE6 required for transport of a-factor. The ste6(cefl-1) allele was recovered and sequenced. The ste6(cefl-1) allele contained a stop codon predicted to truncate St

APA, Harvard, Vancouver, ISO, and other styles

5

Xia, J., and J. Zhou. "Antitumor activity of patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells: In vitro results and clinical responses." Journal of Clinical Oncology 27, no. 15_suppl (2009): 3056. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.3056.

Full text

Abstract:

3056 Background: Renal cell carcinoma (RCC) has been shown to be highly susceptible to immune-based treatment strategies. Methods: In the present study, patient-derived tumor cells were fused with allogeneic dendritic cells (DC) to elicit antitumor activity against RCC. DC from HLA-A2+ healthy donors were fused with primary RCC cells from 10 patients. Phenotype of fusion cells was characterized by flow cytometer and confocal microscopy. In vitro, T-cell proliferation, IFN-γ secretion, and cytotocic T lymphocytes (CTL) activity elicited by allogeneic DC/RCC fusion cells were assessed. Clinicall

APA, Harvard, Vancouver, ISO, and other styles

6

DRIESEN, R., G. DISPERSYN, F. VERHEYEN, et al. "Partial cell fusion: A newly recognized type of communication between dedifferentiating cardiomyocytes and fibroblasts." Cardiovascular Research 68, no. 1 (2005): 37–46. http://dx.doi.org/10.1016/j.cardiores.2005.05.020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Ramulu, K. S., P. Dijkhuis, H. A. Verhoeven, I. Famelaer, and J. Blaas. "Microprotoplast isolation, enrichment and fusion for partial genome transfer in plants." Physiologia Plantarum 85, no. 2 (1992): 315–18. http://dx.doi.org/10.1111/j.1399-3054.1992.tb04740.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Tam, Beatrice M., Orson L. Moritz, Lawrence B. Hurd, and David S. Papermaster. "Identification of an Outer Segment Targeting Signal in the Cooh Terminus of Rhodopsin Using Transgenic Xenopus laevis." Journal of Cell Biology 151, no. 7 (2000): 1369–80. http://dx.doi.org/10.1083/jcb.151.7.1369.

Full text

Abstract:

Mislocalization of the photopigment rhodopsin may be involved in the pathology of certain inherited retinal degenerative diseases. Here, we have elucidated rhodopsin's targeting signal which is responsible for its polarized distribution to the rod outer segment (ROS). Various green fluorescent protein (GFP)/rhodopsin COOH-terminal fusion proteins were expressed specifically in the major red rod photoreceptors of transgenic Xenopus laevis under the control of the Xenopus opsin promoter. The fusion proteins were targeted to membranes via lipid modifications (palmitoylation and myristoylation) as

APA, Harvard, Vancouver, ISO, and other styles

9

Grewal, T. S., P. J. Lowry, and D. Savva. "Expression and partial purification of human pro-opiomelanocortin in Escherichia coli." Journal of Molecular Endocrinology 3, no. 2 (1989): 105–12. http://dx.doi.org/10.1677/jme.0.0030105.

Full text

Abstract:

ABSTRACT A large portion of the human pro-opiomelanocortin (POMC) peptide corresponding to amino acid residues 59–241 has been cloned and expressed in Escherichia coli. A 1·0 kb DNA fragment encoding this peptide was cloned into the expression vectors pUC8 and pUR291. Plasmid pJMBG51 (a pUC8 recombinant) was found to direct the expression of a 24 kDa peptide. The recombinant pUR291 (pJMBG52) was shown to produce a β-galactosidase fusion protein of 140 kDa. Western blot analysis showed that both the 24 kDa and 140 kDa peptides are recognized by antibodies raised against POMC-derived peptides. T

APA, Harvard, Vancouver, ISO, and other styles

10

Avitabile, Elisa, Giulia Lombardi, Tatiana Gianni, Miriam Capri, and Gabriella Campadelli-Fiume. "Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression." Journal of Virology 78, no. 15 (2004): 8015–25. http://dx.doi.org/10.1128/jvi.78.15.8015-8025.2004.

Full text

Abstract:

ABSTRACT Syncytium formation in cells that express herpes simplex virus glycoprotein B (gB), gD, gH, and gL is blocked by gK (E. Avitabile, G. Lombardi, and G. Campadelli-Fiume, J. Virol. 77:6836-6844, 2003). Here, we report the results of two series of experiments. First, UL20 protein (UL20p) expression weakly inhibited cell-cell fusion. Coexpression of UL20p and gK drastically reduced fusion in a cell-line-dependent manner, with the highest inhibition in BHK cells. Singly expressed UL20p and gK localized at the endoplasmic reticulum and nuclear membranes. When they were coexpressed, both pro

APA, Harvard, Vancouver, ISO, and other styles

11

Gianni, Tatiana, Pier Luigi Martelli, Rita Casadio та Gabriella Campadelli-Fiume. "The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family". Journal of Virology 79, № 5 (2005): 2931–40. http://dx.doi.org/10.1128/jvi.79.5.2931-2940.2005.

Full text

Abstract:

ABSTRACT Human herpesviruses enter cells by fusion with target membranes, a process that requires three conserved glycoproteins: gB, gH, and gL. How these glycoproteins execute fusion is unknown. Neural network bioinformatics predicted a membrane α-helix contained within the ectodomain of herpes simplex virus (HSV) gH, positionally conserved in the gH of all examined herpesviruses. Evidence that it has attributes of an internal fusion peptide rests on the following lines of evidence. (i) The predicted membrane α-helix has the attribute of a membrane segment, since it transformed a soluble form

APA, Harvard, Vancouver, ISO, and other styles

12

Lynch, Kara L., Roy R. L. Gerona, Dana M. Kielar, Sascha Martens, Harvey T. McMahon, and Thomas F. J. Martin. "Synaptotagmin-1 Utilizes Membrane Bending and SNARE Binding to Drive Fusion Pore Expansion." Molecular Biology of the Cell 19, no. 12 (2008): 5093–103. http://dx.doi.org/10.1091/mbc.e08-03-0235.

Full text

Abstract:

In regulated vesicle exocytosis, SNARE protein complexes drive membrane fusion to connect the vesicle lumen with the extracellular space. The triggering of fusion pore formation by Ca2+ is mediated by specific isoforms of synaptotagmin (Syt), which employ both SNARE complex and membrane binding. Ca2+ also promotes fusion pore expansion and Syts have been implicated in this process but the mechanisms involved are unclear. We determined the role of Ca2+-dependent Syt-effector interactions in fusion pore expansion by expressing Syt-1 mutants selectively altered in Ca2+-dependent SNARE binding or

APA, Harvard, Vancouver, ISO, and other styles

13

Nye, Anne C., Ramji R. Rajendran, David L. Stenoien, Michael A. Mancini, Benita S. Katzenellenbogen, and Andrew S. Belmont. "Alteration of Large-Scale Chromatin Structure by Estrogen Receptor." Molecular and Cellular Biology 22, no. 10 (2002): 3437–49. http://dx.doi.org/10.1128/mcb.22.10.3437-3449.2002.

Full text

Abstract:

ABSTRACT The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily important in human physiology and disease, recruits coactivators which modify local chromatin structure. Here we describe effects of ER on large-scale chromatin structure as visualized in live cells. We targeted ER to gene-amplified chromosome arms containing large numbers of lac operator sites either directly, through a lac repressor-ER fusion protein (lac rep-ER), or indirectly, by fusing lac repressor with the ER interaction domain of the coactivator steroid receptor coactivator 1. Significant deconden

APA, Harvard, Vancouver, ISO, and other styles

14

Ohtake, Shinji, Takashi Kawahara, Go Noguchi, et al. "Renal Cell Carcinoma in a Horseshoe Kidney Treated with Laparoscopic Partial Nephrectomy." Case Reports in Oncological Medicine 2018 (June 7, 2018): 1–3. http://dx.doi.org/10.1155/2018/7135180.

Full text

Abstract:

Introduction. Horseshoe kidney is one of the most common congenital renal fusion anomalies. Due to its poor mobility and abnormal vasculature form, surgeons should pay close attention to all anatomical variations. Case Presentation. An 83-year-old woman was referred to our hospital because of left renal tumor in a horseshoe kidney incidentally found by her previous hospital. We performed laparoscopic partial nephrectomy. The pathological diagnosis was clear cell renal cell carcinoma. G2 INFα V-pT1a with a negative surgical margin. No evidence of recurrence has been noted, and the renal functio

APA, Harvard, Vancouver, ISO, and other styles

15

Lee, Kyung-Yeol, Thomas R. Broker, and Louise T. Chow. "Transcription Factor YY1 Represses Cell-Free Replication from Human Papillomavirus Origins." Journal of Virology 72, no. 6 (1998): 4911–17. http://dx.doi.org/10.1128/jvi.72.6.4911-4917.1998.

Full text

Abstract:

ABSTRACT We have established cell-free replication for the human papillomavirus type 18 (HPV-18) origin of replication (ori)-containing DNA by using purified HPV-18 E1 and E2 gene products expressed as fusion proteins in Escherichia coli. The transcription factor YY1 has been shown to regulate RNA transcription by binding to a sequence overlapping the putative E1 protein binding site in the HPV-18 ori. We show that exogenously added YY1 fusion protein inhibited HPV-18 orireplication. Cotransfection of YY1 expression vectors also inhibited transient replication in 293 cells. However, inhibition

APA, Harvard, Vancouver, ISO, and other styles

16

Imhof, Simon, Cristina Fragoso, Andrew Hemphill, et al. "Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?" F1000Research 5 (April 14, 2016): 682. http://dx.doi.org/10.12688/f1000research.8249.1.

Full text

Abstract:

Diverse structures facilitate direct exchange of proteins between cells, including plasmadesmata in plants and tunnelling nanotubes in bacteria and higher eukaryotes. Here we describe a new mechanism of protein transfer, flagellar membrane fusion, in the unicellular parasite Trypanosoma brucei. When fluorescently tagged trypanosomes were co-cultured, a small proportion of double-positive cells were observed. The formation of double-positive cells was dependent on the presence of extracellular calcium and was enhanced by placing cells in medium supplemented with fresh bovine serum. Time-lapse m

APA, Harvard, Vancouver, ISO, and other styles

17

Salsman, Jayme, Deniz Top, Julie Boutilier, and Roy Duncan. "Extensive Syncytium Formation Mediated by the Reovirus FAST Proteins Triggers Apoptosis-Induced Membrane Instability." Journal of Virology 79, no. 13 (2005): 8090–100. http://dx.doi.org/10.1128/jvi.79.13.8090-8100.2005.

Full text

Abstract:

ABSTRACT The fusion-associated small transmembrane (FAST) proteins of the fusogenic reoviruses are the only known examples of membrane fusion proteins encoded by nonenveloped viruses. While the involvement of the FAST proteins in mediating extensive syncytium formation in virus-infected and -transfected cells is well established, the nature of the fusion reaction and the role of cell-cell fusion in the virus replication cycle remain unclear. To address these issues, we analyzed the syncytial phenotype induced by four different FAST proteins: the avian and Nelson Bay reovirus p10, reptilian reo

APA, Harvard, Vancouver, ISO, and other styles

18

Couts, Kasey L., Caroline E. McCoach, Danielle Murphy, et al. "Acral Lentiginous Melanoma Harboring a ROS1 Gene Fusion With Clinical Response to Entrectinib." JCO Precision Oncology, no. 1 (November 2017): 1–7. http://dx.doi.org/10.1200/po.16.00013.

Full text

Abstract:

Purpose ROS1 gene fusions demonstrate oncogenic activity, and patients with non–small-cell lung cancer (NSCLC) harboring a ROS1 fusion benefit from the use of a ROS1 inhibitor; however, clinical response to ROS1 inhibitors remains largely uncharacterized outside of NSCLC. ROS1 fusions have been identified in multiple tumor types but have not been reported in cutaneous melanoma. Patients and Methods Tumors from 22 patients with acral lentiginous melanoma (ALM) were analyzed with targeted RNA sequencing to detect fusions in ROS1, NTRK1, NTRK2, NTRK3, and ALK genes. A patient harboring a ROS1 fus

APA, Harvard, Vancouver, ISO, and other styles

19

Leblanc, Andréanne, Scott Owen, Pierre Olivier Fiset, Andrea Liliam Gomez Corrador, Jordan Isenberg, and Nathaniel Bouganim. "Metastatic Large-Cell Neuroendocrine Lung Carcinoma With ALK Fusion Oncogene With Partial Response to Alectinib." JCO Precision Oncology, no. 5 (May 2021): 802–7. http://dx.doi.org/10.1200/po.20.00348.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Valbuena, Noelia, Michal Letek, Angelina Ramos, et al. "Morphological changes and proteome response of Corynebacterium glutamicum to a partial depletion of FtsI." Microbiology 152, no. 8 (2006): 2491–503. http://dx.doi.org/10.1099/mic.0.28773-0.

Full text

Abstract:

In Corynebacterium glutamicum, as in many Gram-positive bacteria, the cell division gene ftsI is located at the beginning of the dcw cluster, which comprises cell division- and cell wall-related genes. Transcriptional analysis of the cluster revealed that ftsI is transcribed as part of a polycistronic mRNA, which includes at least mraZ, mraW, ftsL, ftsI and murE, from a promoter that is located upstream of mraZ. ftsI appears also to be expressed from a minor promoter that is located in the intergenic ftsL–ftsI region. It is an essential gene in C. glutamicum, and a reduced expression of ftsI l

APA, Harvard, Vancouver, ISO, and other styles

21

Taylor, Justin, Christina Marcelus, Dean Pavlick, et al. "Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies." Blood 130, Suppl_1 (2017): 794. http://dx.doi.org/10.1182/blood.v130.suppl_1.794.794.

Full text

Abstract:

Abstract Chromosomal rearrangements involving the neurotrophic receptor tyrosine kinases NTRK1-3 produce oncogenic fusions in a wide variety of adult and pediatric cancers. Although the frequency of NTRK fusions in most cancers is &lt;5%, efficacy in solid tumors harboring these fusions is striking with a 76% durable response rate recently reported with the highly selective pan-TRK inhibitor larotrectinib (LOXO-101) in a cohort comprised of 17 unique tumor types. By contrast, the frequency of NTRK fusions is not well appreciated in hematologic malignancies and targeting of NTRK fusions has

APA, Harvard, Vancouver, ISO, and other styles

22

Montoya-Cerrillo, D. M., J. A. Diaz-Perez, and A. E. Rosenberg. "Novel Gene Fusions in Rhabdomyosarcoma." American Journal of Clinical Pathology 154, Supplement_1 (2020): S156. http://dx.doi.org/10.1093/ajcp/aqaa161.341.

Full text

Abstract:

Abstract Introduction/Objective Rhabdomyosarcoma (RMS) encompasses a heterogeneous group of tumors with striated muscle morphology and/or immunophenotype. Molecular analysis of rhabdomyosarcoma has identified a number of aberrations useful for classification. Initially, fusion associated RMS was restricted to tumors with FOXO1 rearrangements, confirming the diagnosis of alveolar RMS, and identifying patients with poor-outcome. Spindle cell RMS, have been described with VGLL2 fusions, EWSR1/FUS-TFCP2 rearrangements, and myoD1 mutations. In addition, NCOA2-MEIS1 fusion gene was recently describe

APA, Harvard, Vancouver, ISO, and other styles

23

Brizzio, V., A. E. Gammie, G. Nijbroek, S. Michaelis, and M. D. Rose. "Cell fusion during yeast mating requires high levels of a-factor mating pheromone." Journal of Cell Biology 135, no. 6 (1996): 1727–39. http://dx.doi.org/10.1083/jcb.135.6.1727.

Full text

Abstract:

During conjugation, two yeast cells fuse to form a single zygote. Cell fusion requires extensive remodeling of the cell wall, both to form a seal between the two cells and to remove the intervening material. The two plasma membranes then fuse to produce a continuous cytoplasm. We report the characterization of two cell fusion defective (Fus-) mutants, fus5 and fus8, isolated previously in our laboratory. Fluorescence and electron microscopy demonstrated that the fus5 and fus8 mutant zygotes were defective for cell wall remodeling/removal but not plasma membrane fusion. Strikingly, fus5 and fus

APA, Harvard, Vancouver, ISO, and other styles

24

Acquistapace, Adrien, Thierry Bru, Pierre-François Lesault, et al. "Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer." STEM CELLS 29, no. 5 (2011): 812–24. http://dx.doi.org/10.1002/stem.632.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Jones, Arwyn T., Ian G. Mills, Axel J. Scheidig, Kirill Alexandrov, and Michael J. Clague. "Inhibition of Endosome Fusion by Wortmannin Persists in the Presence of Activated rab5." Molecular Biology of the Cell 9, no. 2 (1998): 323–32. http://dx.doi.org/10.1091/mbc.9.2.323.

Full text

Abstract:

Rab5-dependent endosome fusion is sensitive to the phosphoinositide 3-kinase inhibitor, wortmannin. It has been proposed that phosphoinositide 3-kinase activity may be required for activation of rab5 by influencing its nucleotide cycle such as to promote its active GTP state. In this report we demonstrate that endosome fusion remains sensitive to wortmannin despite preloading of endosomes with stimulatory levels of a GTPase-defective mutant rab5Q79L or of a xanthosine triphosphate-binding mutant, rab5D136N, in the presence of the nonhydrolysable analogue XTPγS. These results suggest that activ

APA, Harvard, Vancouver, ISO, and other styles

26

Benidir, Tarik, Tiago Jacometo Coelho de Castilho, Guilherme Rodrigo Lobo Cherubini, and Murilo De Almeida Luz. "Laparoscopic partial nephrectomy for renal cell carcinoma in a horseshoe kidney." Canadian Urological Association Journal 8, no. 11-12 (2014): 918. http://dx.doi.org/10.5489/cuaj.2289.

Full text

Abstract:

Horseshoe kidney has an incidence rate ranging from 1 in 400 to 1 in 1000, with a 2:1 ratio in men. It also has a predilection for chromosomal aneuploidies. From a pathophysiology standpoint, this anomaly occurs during the second to sixth week of gestation when the inferior portion of the metanephric blastema fuses to form an isthmus, commonly in the lower renal pole (90%). As a result of this fusion, the kidney may not bypass the inferior mesenteric artery and is impeded in its ascent. With an aberrant anatomical orientation and location, complications arise including hydronephrosis, renal ca

APA, Harvard, Vancouver, ISO, and other styles

27

Meyer, Claus, Mariana Emerenciano, Eva A. Coenen, et al. "What Is New? An Update of the MLL Recombinome Including the Three Novel Partner Genes ABI2, PDS5A, and TOP3A." Blood 118, no. 21 (2011): 1351. http://dx.doi.org/10.1182/blood.v118.21.1351.1351.

Full text

Abstract:

Abstract Abstract 1351 Chromosomal rearrangements of the MLL gene are associated with pediatric and adult de novo as well as therapy related acute myeloid leukemias, acute lymphoid leukemias, biphenotypic leukemias, and myelodysplastic syndromes. So far more than 70 MLL fusion partner genes have been characterized at the molecular level involving nearly all chromosomes. Though 11q23 rearrangements are associated with high-risk leukemias the clinical outcome of MLL rearrangements depends highly on the specific fusion partner involved. Nearly 40% of these partner genes have been identified at th

APA, Harvard, Vancouver, ISO, and other styles

28

Yamashita, Y., R. Terada, S. Nishibayashi, and K. Shimamoto. "Asymmetric somatic hybrids of Brassica: partial transfer of B. campestris genome into B. oleracea by cell fusion." Theoretical and Applied Genetics 77, no. 2 (1989): 189–94. http://dx.doi.org/10.1007/bf00266185.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Abe, Akihiro, Nobuhiko Emi, Mitsune Tanimoto, Hiroshi Terasaki, Toru Marunouchi та Hidehiko Saito. "Fusion of the Platelet-Derived Growth Factor Receptor β to a Novel Gene CEV14 in Acute Myelogenous Leukemia After Clonal Evolution". Blood 90, № 11 (1997): 4271–77. http://dx.doi.org/10.1182/blood.v90.11.4271.

Full text

Abstract:

Abstract Chromosomal translocations involving band 5q31-35 occur in several hematologic disorders. A clone with a t(5; 14)(q33; q32) translocation appeared at the relapse phase in a patient with acute myelogenous leukemia who exhibited a sole chromosomal translocation, t(7; 11), at initial diagnosis. After the appearance of this clone, the leukemia progressed with marked eosinophilia, and combination chemotherapy was ineffective. Southern blot analysis showed a rearrangement of the platelet-derived growth factor receptor β (PDGFRβ) gene at 5q33 which was not observed at initial diagnosis. This

APA, Harvard, Vancouver, ISO, and other styles

30

Abe, Akihiro, Nobuhiko Emi, Mitsune Tanimoto, Hiroshi Terasaki, Toru Marunouchi та Hidehiko Saito. "Fusion of the Platelet-Derived Growth Factor Receptor β to a Novel Gene CEV14 in Acute Myelogenous Leukemia After Clonal Evolution". Blood 90, № 11 (1997): 4271–77. http://dx.doi.org/10.1182/blood.v90.11.4271.4271_4271_4277.

Full text

Abstract:

Chromosomal translocations involving band 5q31-35 occur in several hematologic disorders. A clone with a t(5; 14)(q33; q32) translocation appeared at the relapse phase in a patient with acute myelogenous leukemia who exhibited a sole chromosomal translocation, t(7; 11), at initial diagnosis. After the appearance of this clone, the leukemia progressed with marked eosinophilia, and combination chemotherapy was ineffective. Southern blot analysis showed a rearrangement of the platelet-derived growth factor receptor β (PDGFRβ) gene at 5q33 which was not observed at initial diagnosis. This transloc

APA, Harvard, Vancouver, ISO, and other styles

31

Ramalho-Santos, João, Maria C. Pedroso de Lima, and Shlomo Nir. "Partial Fusion Activity of Influenza Virus toward Liposomes and Erythrocyte Ghosts Is Distinct from Viral Inactivation." Journal of Biological Chemistry 271, no. 39 (1996): 23902–6. http://dx.doi.org/10.1074/jbc.271.39.23902.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

ICHIO and EIJIRO OZAWA. "Partial Purification from Chick Embryos of a Factor which Promotes Myoblast Proliferation and Delays Fusion. (myoblast proliferation/myoblast fusion/embryo extract/fibroblast growth factor)." Development, Growth and Differentiation 27, no. 6 (1985): 717–28. http://dx.doi.org/10.1111/j.1440-169x.1985.00717.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Meyer, Claus, Eric Kowarz, Julia Hofmann, et al. "New Insights to the MLL Recombinome Including 8 Novel Partner Genes ACTN4, C2CD3, DCP1A, FLNA, LAMC3, LOC100128568, NRIP3, and TNRC18." Blood 112, no. 11 (2008): 2047. http://dx.doi.org/10.1182/blood.v112.11.2047.2047.

Full text

Abstract:

Abstract Rearrangements of the MLL (mixed lineage leukemia) gene are associated with pediatric, adult and therapy-related acute leukemias of both the myeloid and lymphoid lineage. Today, about 60 MLL fusion partner genes have been characterized at the molecular level involving almost all chromosomes. Nearly one-third of these partner genes have been identified at the DCAL (Diagnostic Center of Acute Leukemia) where more than 700 MLL rearrangements, including 36 different partner genes, have been analyzed so far. 85% of the analyzed MLL rearrangements account for the 6 most frequent partner gen

APA, Harvard, Vancouver, ISO, and other styles

34

LEE, Kun Ho, Dae Gun KIM, Nah Young SHIN та ін. "NF-κB-dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts". Biochemical Journal 324, № 1 (1997): 237–42. http://dx.doi.org/10.1042/bj3240237.

Full text

Abstract:

The activity of nitric oxide synthase (NOS) has recently been shown to increase transiently but dramatically in chick embryonic myoblasts that are competent for fusion and that NO acts as a messenger for the cell fusion. Here we show that the rise in NOS activity is tightly correlated with an increase in NOS protein level, and its synthesis is under transcriptional control. In addition, a partial cDNA sequence of NOS obtained by reverse transcription PCR on total RNA from chick myoblasts was found to be identical with that of the inducible type of NOS (iNOS) from chick macrophage. Thus chick m

APA, Harvard, Vancouver, ISO, and other styles

35

Vergne, Isabelle, Rutilio A. Fratti, Preston J. Hill, Jennifer Chua, John Belisle, and Vojo Deretic. "Mycobacterium tuberculosisPhagosome Maturation Arrest: Mycobacterial Phosphatidylinositol Analog Phosphatidylinositol Mannoside Stimulates Early Endosomal Fusion." Molecular Biology of the Cell 15, no. 2 (2004): 751–60. http://dx.doi.org/10.1091/mbc.e03-05-0307.

Full text

Abstract:

Mycobacterium tuberculosis is a facultative intracellular pathogen that parasitizes macrophages by modulating properties of the Mycobacterium-containing phagosome. Mycobacterial phagosomes do not fuse with late endosomal/lysosomal organelles but retain access to early endosomal contents by an unknown mechanism. We have previously reported that mycobacterial phosphatidylinositol analog lipoarabinomannan (LAM) blocks a trans-Golgi network-to-phagosome phosphatidylinositol 3-kinase-dependent pathway. In this work, we extend our investigations of the effects of mycobacterial phosphoinositides on h

APA, Harvard, Vancouver, ISO, and other styles

36

Artero, Ruben D., Irinka Castanon, and Mary K. Baylies. "The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling." Development 128, no. 21 (2001): 4251–64. http://dx.doi.org/10.1242/dev.128.21.4251.

Full text

Abstract:

Hibris (Hbs) is a transmembrane immunoglobulin-like protein that shows extensive homology to Drosophila Sticks and stones (Sns) and human kidney protein Nephrin. Hbs is expressed in embryonic visceral, somatic and pharyngeal mesoderm among other tissues. In the somatic mesoderm, Hbs is restricted to fusion competent myoblasts and is regulated by Notch and Ras signaling pathways. Embryos that lack or overexpress hbs show a partial block of myoblast fusion, followed by abnormal muscle morphogenesis. Abnormalities in visceral mesoderm are also observed. In vivo mapping of functional domains sugge

APA, Harvard, Vancouver, ISO, and other styles

37

Chien, Mei Fang, Naoya Ikeda, Kengo Kubota, and Chihiro Inoue. "Construction of a Cell Surface Engineered Yeast Aims to Selectively Recover Molybdenum, a Rare Metal." Solid State Phenomena 262 (August 2017): 421–24. http://dx.doi.org/10.4028/www.scientific.net/ssp.262.421.

Full text

Abstract:

The depletion of rare metals is an issue of major concern since rare metals are limited in the abundance but essential for high technology industry. However, the present rare metal recovery technical by chemical methods has high environmental impact, poor selectivity, and is too expensive to be practical. To resolve these problems, this study aimed to create a rare metal recover system using yeast, and molybdenum was selected as the first target. A molybdenum binding protein, ModE, which was derived from Escherichia coli was selected. A fusion gene was generated by linking partial modE with a

APA, Harvard, Vancouver, ISO, and other styles

38

WELCH, D. R., D. V. ROSE, W. M. SHARP, C. L. OLSON, and S. S. YU. "Effects of preneutralization on heavy ion fusion chamber transport." Laser and Particle Beams 20, no. 4 (2002): 621–25. http://dx.doi.org/10.1017/s0263034602204279.

Full text

Abstract:

Beams for heavy ion fusion are likely to require at least partial neutralization in the reactor chamber. Present target designs call for higher beam currents and smaller focal spots than most earlier designs, leading to high space-charge fields. Focusing is complicated by beam stripping in the low-pressure background gas expected in chambers. One method proposed for neutralization is passing an ion beam through a plasma before the beam enters the chamber. In this article, the electromagnetic particle-in-cell code LSP is used to study the effectiveness of this form of preneutralization for a ra

APA, Harvard, Vancouver, ISO, and other styles

39

Emans, N., J. P. Gorvel, C. Walter, et al. "Annexin II is a major component of fusogenic endosomal vesicles." Journal of Cell Biology 120, no. 6 (1993): 1357–69. http://dx.doi.org/10.1083/jcb.120.6.1357.

Full text

Abstract:

We have used an in vitro assay to follow the proteins transferred from a donor to an acceptor upon fusion of early endosomes. The acceptor was a purified early endosomal fraction immunoisolated on beads and the donor was a metabolically-labeled early endosomal fraction in suspension. In the assay, both fractions were mixed in the presence of unlabeled cytosol, and then the beads were retrieved and washed. The donor proteins transferred to the acceptor were identified by two-dimensional gel electrophoresis and autoradiography. Approximately 50 major proteins were transferred and this transfer f

APA, Harvard, Vancouver, ISO, and other styles

40

Avigan, David, Jacalyn Rosenblatt, Baldev Vasir, et al. "Vaccination with DC/Multiple Myeloma Fusions in Conjunction with Stem Cell Transplantation." Blood 110, no. 11 (2007): 578. http://dx.doi.org/10.1182/blood.v110.11.578.578.

Full text

Abstract:

Abstract Autologous transplantation results in the transient reversal of tumor mediated tolerance due to the reduction in disease bulk, the depletion of regulatory T cells, and in the increased presence of tumor reactive lymphocytes during the period of lymphopoietic reconstitution. As a result, cancer vaccines are being explored as a means of targeting residual myeloma cells following stem cell transplant. We have developed a cancer vaccine in which patient derived tumor cells are fused with autologous dendritic cells (DCs). In this way multiple tumor antigens are presented in the context of

APA, Harvard, Vancouver, ISO, and other styles

41

Tufegdzic, Milomir, Vladimir Vasic, and Jovan Hadzi-Djokic. "Renal cell carcinoma of horseshoe kidney." Srpski arhiv za celokupno lekarstvo, no. 00 (2020): 72. http://dx.doi.org/10.2298/sarh200617072t.

Full text

Abstract:

Introduction. Horseshoe kidney is the most common developmental disorder of the urinary system, which involves an anomaly of kidney fusion, and occurs in 3% of the population. Kidneys are most often connected at the lower poles by fibrous or parenchymal isthmus. Renal cell carcinoma (RCC) is the most common tumor of the horseshoe kidney. Treatment involves surgical treatment that includes heminephrectomy or partial nephrectomy with different approaches. We report a case of RCC of a horseshoe kidney, located on lower pole and isthmus. Case outline. A sixty-eight-year-old patient reported to the

APA, Harvard, Vancouver, ISO, and other styles

42

Zhang, Y., D. Featherstone, W. Davis, E. Rushton, and K. Broadie. "Drosophila D-titin is required for myoblast fusion and skeletal muscle striation." Journal of Cell Science 113, no. 17 (2000): 3103–15. http://dx.doi.org/10.1242/jcs.113.17.3103.

Full text

Abstract:

An ethylmethane sulfonate (EMS) mutagenesis of Drosophila melanogaster aimed at discovering novel genes essential for neuromuscular development identified six embryonic lethal alleles of one genetic locus on the third chromosome at 62C. Two additional lethal P element insertion lines, l(3)S02001 and l(3)j1D7, failed to complement each other and each of the six EMS alleles. Analysis of genomic sequence bracketing the two insertion sites predicted a protein of 16,215 amino acid residues, encoded by a 70 kb genomic region. This sequence includes the recently characterized kettin, and includes all

APA, Harvard, Vancouver, ISO, and other styles

43

Familiades, Julien, Marina Bousquet, Nicole Dastugue, et al. "PAX5 Mutations Occur Frequently in Adult B-Cell Acute Lymphoblastic Leukemia (B-ALL) and Is Significantly Associated with BCR-ABL1 Fusion Gene." Blood 110, no. 11 (2007): 2806. http://dx.doi.org/10.1182/blood.v110.11.2806.2806.

Full text

Abstract:

Abstract PAX5 is a transcription factor central to B-cell differentiation, frequently mutated in pediatric B-ALL (38.9% in 192 B-ALL, Nature,2007;446:758). PAX5 mutations consist in whole or partial gene deletions or amplifications, fusion gene or point mutations. Adult B-ALL differs in many regards from pediatric B-ALL as demonstrated by differences in prognosis and genetic abnormalities (ETV6-RUNX1 almost absent from adult; BCR-ABL1 rare in children). We screened the occurrence of PAX5 mutations in a series of 119 adult patients with B-lineage ALL prospectively treated in the GRAALL-2003 (pe

APA, Harvard, Vancouver, ISO, and other styles

44

Perreault, Sébastien, François Doz, Birgit Geoerger, et al. "RARE-07. EFFICACY AND SAFETY OF LAROTRECTINIB IN PEDIATRIC PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION-POSITIVE PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS." Neuro-Oncology 23, Supplement_1 (2021): i42. http://dx.doi.org/10.1093/neuonc/noab090.168.

Full text

Abstract:

Abstract Background NTRK gene fusions are oncogenic drivers in various CNS and non-CNS tumors. Larotrectinib is a highly selective TRK inhibitor approved to treat patients with TRK fusion cancer, with an objective response rate (ORR) of 78% across multiple non-CNS cancers (McDermott et al, ESMO 2020). We report updated data on pediatric patients with TRK fusion-positive primary CNS tumors. Methods Patients aged &lt;18 years with primary CNS tumors harboring an NTRK gene fusion enrolled in two clinical trials (NCT02637687, NCT02576431) were identified. Larotrectinib was administered until d

APA, Harvard, Vancouver, ISO, and other styles

45

Surowy, C. S., V. L. van Santen, S. M. Scheib-Wixted, and R. A. Spritz. "Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA." Molecular and Cellular Biology 9, no. 10 (1989): 4179–86. http://dx.doi.org/10.1128/mcb.9.10.4179-4186.1989.

Full text

Abstract:

We have studied the interaction of two of the U1 small nuclear ribonucleoprotein (snRNP)-specific proteins, U1-70K and U1-A, with U1 small nuclear RNA (snRNA). The U1-70K protein is a U1-specific RNA-binding protein. Deletion and mutation analyses of a beta-galactosidase/U1-70K partial fusion protein indicated that the central portion of the protein, including the RNP sequence domain, is both necessary and sufficient for specific U1 snRNA binding in vitro. The highly conserved eight-amino-acid RNP consensus sequence was found to be essential for binding. Deletion and mutation analyses of U1 sn

APA, Harvard, Vancouver, ISO, and other styles

46

Yan, Xiaomei, Yoshihiro Hayashi, Xinghui Zhao та ін. "RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development". Blood 124, № 21 (2014): 2187. http://dx.doi.org/10.1182/blood.v124.21.2187.2187.

Full text

Abstract:

Abstract Transcription factors RUNX1/CBFβ play critical roles in hematopoiesis. Both of them are frequently involved in chromosomal translocations, point mutations, or deletions in acute leukemia. The mixed lineage leukemia (MLL) gene is also frequently involved in chromosomal translocations or partial tandem duplication in acute leukemia. We have previously shown that MLL, RUNX1, and CBFβ interact and form a regulatory complex to regulate downstream target genes. However, the functional consequence of MLL fusions on RUNX1/CBFβ activity remains unknown. To determine the impact of MLL fusion pr

APA, Harvard, Vancouver, ISO, and other styles

47

Komma, D. J., and S. A. Endow. "Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C." Journal of Cell Science 110, no. 2 (1997): 229–37. http://dx.doi.org/10.1242/jcs.110.2.229.

Full text

Abstract:

Ncd is a kinesin-related microtubule motor protein required for chromosome segregation in Drosophila oocytes and early embryos. In tests for interactions with other proteins, we find that mutants of alpha Tub67C, which affect an oocyte- and early embryo-specific alpha-tubulin, enhance meiotic nondisjunction and zygotic loss of ncdD, a partial loss-of-function mutant of ncd. The enhancement is dominant and allele-specific with respect to alpha Tub67C, and depends on the recessive effects of ncdD. Cytologically, embryos of alpha Tub67C/+ show delayed meiotic divisions and defective female pronuc

APA, Harvard, Vancouver, ISO, and other styles

48

Popovic, Relja, Laurie E. Riesbeck, Chinavenmeni S. Velu, et al. "Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization." Blood 113, no. 14 (2009): 3314–22. http://dx.doi.org/10.1182/blood-2008-04-154310.

Full text

Abstract:

Abstract Chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric proteins that cause abnormal expression of a subset of HOX genes and leukemia development. Here, we show that MLL normally regulates expression of mir-196b, a hematopoietic microRNA located within the HoxA cluster, in a pattern similar to that of the surrounding 5′ Hox genes, Hoxa9 and Hoxa10, during embryonic stem (ES) cell differentiation. Within the hematopoietic lineage, mir-196b is most abundant in short-term hematopoietic stem cells and is down-regulated in more differentiated hematopoiet

APA, Harvard, Vancouver, ISO, and other styles

49

Szöllösi, Daniel, Renata Czołowska, Ewa Borsuk, Maria S. Szöllösi, and Pascale Debey. "Nuclear envelope removal/maintenance determines the structural and functional remodelling of embryonic red blood cell nuclei in activated mouse oocytes." Zygote 6, no. 1 (1998): 65–73. http://dx.doi.org/10.1017/s0967199400005098.

Full text

Abstract:

SummaryNuclei of embryonic red blood cells (e-RBC) from 12-day mouse fetuses are arrested in Go phase of the cell cycle and have low transcriptional activity. These nuclei were transferred with help of polyethylene glycol (PEG)-mediated fusion to parthenogenetically activated mouse oocytes and heterokaryons were analysed for nuclear structure and transcriptional activity. If fusion proceeded 25–45 min after oocyte activation, e-RBC nuclei were induced to nuclear envelope breakdown and partial chromatin condensation, followed by formation of nuclei structurally identical with pronuclei. These ‘

APA, Harvard, Vancouver, ISO, and other styles

50

Walz, Christoph, Beate Schultheis, Georgia Metzgeroth, et al. "Transient Response to Imatinib in an Atypical Chronic Myeloproliferative Disease Associated with ins(9;4)(q34;q21q31) and a CDK5RAP2-PDGFRA Fusion Gene." Blood 106, no. 11 (2005): 3281. http://dx.doi.org/10.1182/blood.v106.11.3281.3281.

Full text

Abstract:

Abstract Chronic myeloproliferative disorders (CMPD) associated with rearrangements of the ‘platelet-derived growth factor receptor A’ (PDGFRA) at chromosome 4q12 are excellent candidates for targeted therapy with imatinib. To date, two fusion genes involving PDGFRA have been described: FIP1L1-PDGFRA and BCR-PDGFRA. Here we report a female patient who presented in advanced phase of an atypical myeloproliferative disease. Routine cytogenetic analysis revealed an ins(9;4)(q34;q21q31). Although no break was visible at 4q12, FISH analysis with flanking BAC probes indicated that PDGFRA was disrupte

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!