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Journal articles on the topic 'Particules en cellule (PIC)'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Poirson, Philippe. "Pic de particules fines et inertie des autorités." Revue Médicale Suisse 4, no. 146 (2008): 559a. http://dx.doi.org/10.53738/revmed.2008.4.146.559a.

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Gallinari, F., S. Elmaleh, and R. Ben Aïm. "Influence de la dissipation énergetique sur l'efficacité de la flottation à air dissous : analogie avec la floculation." Revue des sciences de l'eau 9, no. 4 (2005): 485–98. http://dx.doi.org/10.7202/705263ar.

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Les flottateurs à air dissous sont classiquement dimensionnés à partir de deux paramètres: le rapport mA/mS des masses d'air et de solides en présence et le temps de contact entre phases. Une série d'essais effectués sur cinq différentes unités continues ou discontinues montre que ces seules variables opératoires ne suffisent pas à déterminer l'efficacité. De plus, l'extrapolation des données obtenues sur un floculateur discontinu conduirait à des besoins en air dissous considérables pouvant limiter le développement industriel. La dissipation d'énergie, habituellement négligée, peut être quant

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Hengé-Napoli, M. H., E. Ansoborlo, V. Chazel, et al. "Interaction uranium-cellule cible : exemple de la transformation de particules d'UO4dans le macrophage alvéolaire." Radioprotection 32, no. 5 (1997): 625–36. http://dx.doi.org/10.1051/radiopro:1997121.

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I. O., Opowoye, Aderibigbe O. B., Idowu O. P. A., et al. "Production performance, blood profile and egg quality traits of layer chickens fed pelletized feeds of different particle sizes in two housing types." Nigerian Journal of Animal Production 51, no. 2 (2025): 17–35. https://doi.org/10.51791/njap.v51i2.8140.

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Production performance, blood profile and egg quality of 240 commercial layers (21-60 weeks old) fed pelletized feeds of different particle sizes in two housing types were studied. The birds were housed in either Battery cage (BC) of 45×40×45 cm dimension with a stocking rate of 3 birds/ cell (0.07 m2/ bird) or Deep litter (DL) unit with stocking density of 0.39 m2/bird. The feed particle sizes were fine particle pellets ≤ 1 mm and coarse particle pellets ≤ 2 mm. The experiment was arranged in a 2 x 2 factorial layout. Each treatment consisted of 3 replicates with 20 birds each. At age 21 week

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Fortin, JF, R. Cantin, and MJ Tremblay. "Présence des protéines de la cellule hôte sur les particules virales : influences sur le cycle de vie du VIH-1." médecine/sciences 17, no. 2 (2001): 186. http://dx.doi.org/10.4267/10608/1891.

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Roidor, Clara, Karim Chebli, and Maud Borensztein. "Reprogrammation, lignée germinale et empreinte génomique parentale." médecine/sciences 40, no. 12 (2024): 892–903. https://doi.org/10.1051/medsci/2024177.

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Le maintien de l’identité cellulaire par l’épigénome est crucial pour le développement d’un individu. Les marques chromatiniennes assurent la stabilité de l’expression génique. La reprogrammation épigénétique est un phénomène naturel au cours du développement des mammifères, en particulier lors de l’émergence de la lignée germinale. Les cellules germinales primordiales (PGC) subissent un profond remodelage de la chromatine, comprenant une déméthylation globale de l’ADN et l’effacement des empreintes parentales. Cette revue introduit les notions de reprogrammation épigénétique, y compris sa déc

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Brajkovic, S., D. Favre, G. Niederhäuser, R. Regazzi, G. Waeber, and A. Abderrahmani. "P241 L’induction du stress du réticulum endoplasmique contribue au dysfonctionnement de la cellule bêta provoquée par les particules de LDL oxydées." Diabetes & Metabolism 35 (March 2009): A84. http://dx.doi.org/10.1016/s1262-3636(09)72039-7.

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Lopez, Katherine C., Sridhar Kandala, Scott Marek, and Deanna M. Barch. "Development of Network Topology and Functional Connectivity of the Prefrontal Cortex." Cerebral Cortex 30, no. 4 (2019): 2489–505. http://dx.doi.org/10.1093/cercor/bhz255.

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Abstract The prefrontal cortex (PFC) comprises distinct regions and networks that vary in their trajectories across development. Further understanding these diverging trajectories may elucidate the neural mechanisms by which distinct PFC regions contribute to cognitive maturity. In particular, it remains unclear whether PFC regions of distinct network affiliations differ in topology and their relationship to cognition. We examined 615 individuals (8–21 years) to characterize age-related effects in participation coefficient of 28 PFC regions of distinct networks, evaluating connectivity profile

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Ye, Huanpeng, Guangye Li, Xinjun Sheng, and Xiangyang Zhu. "Phase-amplitude coupling between low-frequency scalp EEG and high-frequency intracranial EEG during working memory task." Journal of Neural Engineering 19, no. 2 (2022): 026043. http://dx.doi.org/10.1088/1741-2552/ac63e9.

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Abstract Objective. Revealing the relationship between simultaneous scalp electroencephalography (EEG) and intracranial electroencephalography (iEEG) is of great importance for both neuroscientific research and translational applications. However, whether prominent iEEG features in the high-gamma band can be reflected by scalp EEG is largely unknown. To address this, we investigated the phase-amplitude coupling (PAC) phenomenon between the low-frequency band of scalp EEG and the high-gamma band of iEEG. Approach. We analyzed a simultaneous iEEG and scalp EEG dataset acquired under a verbal wor

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Verheijen, Bert M., Satoru Morimoto, Ryogen Sasaki, et al. "Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains." Journal of Neuropathology & Experimental Neurology 79, no. 8 (2020): 902–7. http://dx.doi.org/10.1093/jnen/nlaa056.

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Abstract Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder that is endemic to the Kii peninsula of Japan. The disorder is clinically characterized by a variable combination of parkinsonism, dementia, and motor neuron symptoms. Despite extensive investigations, the etiology and pathogenesis of ALS/PDC remain unclear. At the neuropathological level, Kii ALS/PDC is characterized by neuronal loss and tau-dominant polyproteinopathy. Here, we report the accumulation of several proteins involved in protein homeostasis pathways, that

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Ndour, N., M. Sarr, A. Deh, et al. "C88: Liposarcome myxoïde à cellules rondes, métastatique de la fesse." African Journal of Oncology 2, no. 1 Supplement (2022): S37. http://dx.doi.org/10.54266/ajo.2.1s.c88.blie5370.

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INTRODUCTION : Le liposarcome est une tumeur mésenchymateuse primitive rare, développée aux dépends des tissus adipeux. Il est constitué de quatre sous-types histologiques notamment les sous- types bien différenciés, myxoïde, pléomorphe et dédifférencié. La localisation préférentielle est la cuisse. Nous rapportons une observation d’un liposarcome myxoïde à cellule ronde à localisation fessière. OBSERVATION : Un homme âgé de 56 ans, vendeur de légumes, originaire de la Guinée Conakry, présentait depuis deux ans une tumeur de la fesse droite. L’examen retrouvait une tumeur inflammatoire, ulcéré

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Gibbs, Samantha J., Rosie M. Sheward, Paul R. Bown, Alex J. Poulton, and Sarah A. Alvarez. "Warm plankton soup and red herrings: calcareous nannoplankton cellular communities and the Palaeocene–Eocene Thermal Maximum." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376, no. 2130 (2018): 20170075. http://dx.doi.org/10.1098/rsta.2017.0075.

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Past global warming events such as the Palaeocene–Eocene Thermal Maximum (PETM—56 Ma) are attributed to the release of vast amounts of carbon into the ocean, atmosphere and biosphere with recovery ascribed to a combination of silicate weathering and organic carbon burial. The phytoplanktonic nannoplankton are major contributors of organic and inorganic carbon but their role in this recovery process remains poorly understood and complicated by their contribution to marine calcification. Biocalcification is implicated not only in long-term carbon burial but also both short-term positive and nega

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Combrisson, Etienne, Timothy Nest, Andrea Brovelli, et al. "Tensorpac: An open-source Python toolbox for tensor-based phase-amplitude coupling measurement in electrophysiological brain signals." PLOS Computational Biology 16, no. 10 (2020): e1008302. http://dx.doi.org/10.1371/journal.pcbi.1008302.

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Despite being the focus of a thriving field of research, the biological mechanisms that underlie information integration in the brain are not yet fully understood. A theory that has gained a lot of traction in recent years suggests that multi-scale integration is regulated by a hierarchy of mutually interacting neural oscillations. In particular, there is accumulating evidence that phase-amplitude coupling (PAC), a specific form of cross-frequency interaction, plays a key role in numerous cognitive processes. Current research in the field is not only hampered by the absence of a gold standard

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Rho, Y., and S. Vijayan. "0124 A Prefrontal-Amygdala Network Model of the Cellular and Circuit-Level Mechanisms of Emotional Memory Consolidation During the Awake State and REM Sleep." Sleep 43, Supplement_1 (2020): A49. http://dx.doi.org/10.1093/sleep/zsaa056.122.

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Abstract Introduction Rapid eye movement (REM) sleep has been implicated in the consolidation of emotional memories. Our recent work found a candidate system for REM-related memory consolidation. We showed that during REM sleep, the frontal cortices are dominated by theta (4–8 Hz) oscillations and bursts of beta (15–35 Hz) activity. Studies suggest that rhythmic interactions between the frontal cortices and limbic structures, in particular the amygdala, play a critical role in the consolidation of emotional memories. However, the mechanisms responsible for memory consolidation during these rhy

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Prudyus, Т. Y., O. I. Vishchur, D. B. Mudrak, Y. І. Kentsalo, T. A. Holubieva, and N. V. Gutsol. "Condition of T- and B-cellular-mediated specific protection in sows and their offspring subject to essential oils." Regulatory Mechanisms in Biosystems 15, no. 4 (2024): 912–16. https://doi.org/10.15421/0224132.

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The objective of the study was identification of the activities of T- and B-cellular mechanisms of specific protection in sows and their offspring subject to essential oil from Origanum vulgare, cinnamaldehydum, extract from Capsicum sp., Rosmarinus officinalis, and Thymus serpyllum in the form of encapsulated feed supplement Aktyvno. The assessment of the activity of the cellular factors of the specific protection was conducted by enumerating T- and B-lymphocytes and assessing their functional ability in peripheral blood of swine in the reaction of spontaneous rosette-formation with ram eryth

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Yulian, Konechnyi, Hrushka Oksana, Pryzyhley Hanna, et al. "Cell immunity of laboratory animals under the influence of 5-indolylmethylene rhodanine-3-carboxylic/sulphonic acid derivative." ScienceRise: Pharmaceutical Science, no. 1(29) (February 27, 2021): 76–81. https://doi.org/10.15587/2519-4852.2021.224328.

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<strong>The aim.</strong> To study the cell immunity status under influence of 3-[5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxo-thiazolidin-3-yl]-propionic acid, as a prominent 4-thiazolidinone derivative and a class of biologically active compounds with polypharmacological properties. <strong>Materials and methods.</strong> Experimental method on the model of laboratory animals (guinea pigs); intradermal allergy tests; relative and absolute content in the peripheral blood of T- and B-lymphocytes subpopulations; hematological indexies: index of the ratio of lymphocytes and monocytes, ind

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Smith, Nancy J., Sara Y. Markowitz, Ann N. Hoffman, and Michael S. Fanselow. "Adaptation of Threat Responses Within the Negative Valence Framework." Frontiers in Systems Neuroscience 16 (May 26, 2022). http://dx.doi.org/10.3389/fnsys.2022.886771.

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External threats are a major source of our experience of negatively valanced emotion. As a threat becomes closer and more real, our specific behavior patterns and our experiences of negative affect change in response to the perceived imminence of threat. Recognizing this, the National Institute of Mental Health’s Research Domain Criteria (RDoC) Negative Valence system is largely based around different levels of threat imminence. This perspective describes the correspondence between the RDoC Negative Valence System and a particular neurobiological/neuroecological model of reactions to threat, t

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Poleksic, Joko, Milan Aksic, Slobodan Kapor, et al. "Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes." Frontiers in Behavioral Neuroscience 15 (November 8, 2021). http://dx.doi.org/10.3389/fnbeh.2021.666547.

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Stressful events experienced during early life are associated with increased vulnerability of developing psychopathology in adulthood. In the present study, we exposed 9-day-old Wistar rats to 24 h maternal deprivation (MD) with the aim to investigate the impact of early life stress (ELS) on morphological, biochemical, and functional aspects of the prefrontal cortex (PFC), a brain region particularly sensitive to stress. We found that in the superficial medial orbital cortex (MO), young adult male rats had reduced density of GAD67 and CCK immunopositive cells, while the rostral part of the ven

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Cheng, Yi, Nan Song, Renkai Ge, and Yue Dai. "Serotonergic Modulation of Persistent Inward Currents in Serotonergic Neurons of Medulla in ePet-EYFP Mice." Frontiers in Neural Circuits 15 (April 6, 2021). http://dx.doi.org/10.3389/fncir.2021.657445.

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Serotonergic (5-HT) neurons in the medulla play multiple functional roles associated with many symptoms and motor activities. The descending serotonergic pathway from medulla is essential for initiating locomotion. However, the ionic properties of 5-HT neurons in the medulla remain unclear. Using whole-cell patch-clamp technique, we studied the biophysical and modulatory properties of persistent inward currents (PICs) in 5-HT neurons of medulla in ePet-EYFP transgenic mice (P3–P6). PICs were recorded by a family of voltage bi-ramps (10-s duration, 40-mV peak step), and the ascending and descen

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Ngolsou, Françis, Eya’ane Meva François, Mésodé Nnangé Akweh, et al. "Évaluation in vivo de l’effet anti-inflammatoire des nanoparticules d'argent obtenues par biosynthèse in situ à partir des feuilles de Psychotria calceata." Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, no. 3 (2023). http://dx.doi.org/10.57220/jatpb.v2i3.119.

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Introduction : Les nanotechnologies sont de nos jours une science qui prend une grande importance en raison de leur simplicité, de leur nature écologique et économique. L’objectif de ce travail consistait à évaluer l’effet anti-inflammatoire des nanoparticules obtenues par biosynthèse in situ à partir de la poudre des feuilles de Psychotria calceata. Matériel et méthodes : La synthèse des nanomatériaux s’est faite à partir d’un infusé de la poudre des feuilles de Psychotria calceata auquel a été ajouté une solution de nitrate d’argent. Les nanoparticules obtenues ont été caractérisées ap

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Saha, Rajib, Deng Liu, Allison Hoynes-O’Connor, et al. "Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. Strain PCC 6803: Insights from Transcriptomic, Fluxomic, and Physiological Analyses." mBio 7, no. 3 (2016). http://dx.doi.org/10.1128/mbio.00464-16.

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ABSTRACT Synechocystis sp. strain PCC 6803 is the most widely studied model cyanobacterium, with a well-developed omics level knowledgebase. Like the lifestyles of other cyanobacteria, that of Synechocystis PCC 6803 is tuned to diurnal changes in light intensity. In this study, we analyzed the expression patterns of all of the genes of this cyanobacterium over two consecutive diurnal periods. Using stringent criteria, we determined that the transcript levels of nearly 40% of the genes in Synechocystis PCC 6803 show robust diurnal oscillating behavior, with a majority of the transcripts being u

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Hauer, Brandon E., Silvia Pagliardini, and Clayton T. Dickson. "Prefrontal-Hippocampal Pathways Through the Nucleus Reuniens Are Functionally Biased by Brain State." Frontiers in Neuroanatomy 15 (January 31, 2022). http://dx.doi.org/10.3389/fnana.2021.804872.

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Circuit-level communication between disparate brain regions is fundamental for the complexities of the central nervous system operation. Co-ordinated bouts of rhythmic activity between the prefrontal cortex (PFC) and hippocampus (HPC), in particular, are important for mnemonic processes. This is true during awake behavior, as well as during offline states like sleep. We have recently shown that the anatomically interposed thalamic nucleus reuniens (RE) has a role in coordinating slow-wave activity between the PFC and HPC. Here, we took advantage of spontaneous brain state changes occurring dur

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Wang, Yifan, Ruiyan Liu, Hong Liu, et al. "Development of a powerful synthetic hybrid promoter to improve the cellulase system of Trichoderma reesei for efficient saccharification of corncob residues." Microbial Cell Factories 21, no. 1 (2022). http://dx.doi.org/10.1186/s12934-021-01727-8.

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Abstract Background The filamentous fungus Trichoderma reesei is a widely used workhorse for cellulase production in industry due to its prominent secretion capacity of extracellular cellulolytic enzymes. However, some key components are not always sufficient in this cellulase cocktail, making the conversion of cellulose-based biomass costly on the industrial scale. Development of strong and efficient promoters would enable cellulase cocktail to be optimized for bioconversion of biomass. Results In this study, a synthetic hybrid promoter was constructed and applied to optimize the cellulolytic

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Shah, Jay, Javad Sohankar, Ji Luo, et al. "A 2.5D residual U‐Net for improved amyloid PET harmonization preserving spatial information." Alzheimer's & Dementia 19, S24 (2023). http://dx.doi.org/10.1002/alz.082690.

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AbstractBackgroundMultiple amyloid tracers with varying characteristics pose a significant challenge to standardized interpretation and quantification of amyloid PET measurements. We previously demonstrated that a deep learning based 2D residual inception encoder‐decoder network (RIED‐Net) architecture improved harmonization of florbetapir (FBP) and PiB PET. However, 2D networks fail to capture spatial information among image slices and 3D networks with more parameters require larger datasets and powerful computation for training. Here, we investigate the performance of a 2.5D approach to furt

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Amengual, Julian L., and Suliann Ben Hamed. "Revisiting Persistent Neuronal Activity During Covert Spatial Attention." Frontiers in Neural Circuits 15 (June 30, 2021). http://dx.doi.org/10.3389/fncir.2021.679796.

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Persistent activity has been observed in the prefrontal cortex (PFC), in particular during the delay periods of visual attention tasks. Classical approaches based on the average activity over multiple trials have revealed that such an activity encodes the information about the attentional instruction provided in such tasks. However, single-trial approaches have shown that activity in this area is rather sparse than persistent and highly heterogeneous not only within the trials but also between the different trials. Thus, this observation raised the question of how persistent the actually persi

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Srinivasan, Dhivya, Ilya M. Nasrallah, Zhijian Yang та ін. "Deep Learning patterns of Aβ accumulation in Alzheimer’s Disease". Alzheimer's & Dementia 19, S17 (2023). http://dx.doi.org/10.1002/alz.080683.

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AbstractBackgroundAccumulation of amyloid (Aß) plaques is an early pathologic change of Alzheimer’s Disease (AD). However, the mechanisms and pathways by which amyloid spreads across the cerebrum are not fully understood. Deriving distinct dimensions of amyloid deposition and their associations with biomedical factors could be useful to understand how amyloid propagates. In this analysis, we identified two distinct subtypes of progression based on spatiotemporal variations using a recently developed data‐driven, deep learning clustering method called Surreal‐GAN1.MethodWe used data from 482 A+

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Liu, Jing, Wei-Yue Xing, Ju-Yuan Zhang, Xiaoli Zeng, Yiling Yang, and Cheng-Cai Zhang. "Functions of the Essential Gene mraY in Cellular Morphogenesis and Development of the Filamentous Cyanobacterium Anabaena PCC 7120." Frontiers in Microbiology 12 (October 21, 2021). http://dx.doi.org/10.3389/fmicb.2021.765878.

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Bacterial cell shape is determined by the peptidoglycan (PG) layer. The cyanobacterium Anabaena sp. PCC 7120 (Anabaena) is a filamentous strain with ovoid-shaped cells connected together with incomplete cell constriction. When deprived of combined nitrogen in the growth medium, about 5–10% of the cells differentiate into heterocysts, cells devoted to nitrogen fixation. It has been shown that PG synthesis is modulated during heterocyst development and some penicillin-binding proteins (PBPs) participating in PG synthesis are required for heterocyst morphogenesis or functioning. Anabaena has mult

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Bergman, Lottem, Aaron J. Krom, Yaniv Sela, et al. "Propofol Anesthesia Concentration Rather Than Abrupt Behavioral Unresponsiveness Linearly Degrades Responses in the Rat Primary Auditory Cortex." Cerebral Cortex, February 15, 2022. http://dx.doi.org/10.1093/cercor/bhab528.

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Abstract Despite extensive knowledge of its molecular and cellular effects, how anesthesia affects sensory processing remains poorly understood. In particular, it remains unclear whether anesthesia modestly or robustly degrades activity in primary sensory regions, and whether such changes are linked to anesthesia drug concentration versus behavioral unresponsiveness, which are typically confounded. Here, we used slow gradual intravenous propofol anesthesia induction together with auditory stimulation and intermittent assessment of behavioral responsiveness while recording epidural electroencep

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Sun, Sai, Hongbo Yu, Rongjun Yu, and Shuo Wang. "Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity." Translational Psychiatry 13, no. 1 (2023). http://dx.doi.org/10.1038/s41398-023-02625-w.

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AbstractProcessing facial expressions of emotion draws on a distributed brain network. In particular, judging ambiguous facial emotions involves coordination between multiple brain areas. Here, we applied multimodal functional connectivity analysis to achieve network-level understanding of the neural mechanisms underlying perceptual ambiguity in facial expressions. We found directional effective connectivity between the amygdala, dorsomedial prefrontal cortex (dmPFC), and ventromedial PFC, supporting both bottom-up affective processes for ambiguity representation/perception and top-down cognit

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Pahl, Jennifer, Prokopis C. Prokopiou, Elisenda Bueicheku, et al. "Left Frontoparietal Connectivity Counteracts Locus Coeruleus‐Related Attentional Decline in Preclinical Alzheimer’s Disease." Alzheimer's & Dementia 19, S16 (2023). http://dx.doi.org/10.1002/alz.079733.

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AbstractBackgroundAutopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies have also ascribed a protective role of the LC against cognitive decline, possibly mediated by prefrontal functional connectivity (FC). Interestingly, higher left frontoparietal network (LFPN) FC provides resilience against cognitive decline in preclinical sporadic or autosomal Alzheimer’s disease (AD). Given that the FPN and the LC play an important role in attentional control, and attention def

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Wang, Jun, Yuanyuan Tian, Ling-Hui Zeng, and Han Xu. "Prefrontal Disinhibition in Social Fear: A Vital Action of Somatostatin Interneurons." Frontiers in Cellular Neuroscience 14 (December 17, 2020). http://dx.doi.org/10.3389/fncel.2020.611732.

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Social fear and avoidance of social partners and social situations represent the core behavioral symptom of Social Anxiety Disorder (SAD), a prevalent psychiatric disorder worldwide. The pathological mechanism of SAD remains elusive and there are no specific and satisfactory therapeutic options currently available. With the development of appropriate animal models, growing studies start to unravel neuronal circuit mechanisms underlying social fear, and underscore a fundamental role of the prefrontal cortex (PFC). Prefrontal cortical functions are implemented by a finely wired microcircuit comp

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Kebets, Valeria, Pauline Favre, Josselin Houenou, et al. "Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation." Translational Psychiatry 11, no. 1 (2021). http://dx.doi.org/10.1038/s41398-021-01666-3.

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AbstractEmotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fronto-limbic brain network, including in particular the amygdala and prefrontal cortex (PFC). Neural variability has recently been suggested as an index of cognitive flexibility. We hypothesized that within-subject neural variability in the fronto-limbic network would be related to inter-individual variation in emotion dysregulation in the context of low affective control. In a multi-site co

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Bellenguez, Céline. "Consensus meta‐analysis of genome‐wide association studies for Alzheimer’s disease across the EADB, PGC‐ALZ and IGAP consortia." Alzheimer's & Dementia 19, S12 (2023). http://dx.doi.org/10.1002/alz.076317.

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AbstractBackgroundA large number of putative genes have been associated with Alzheimer’s disease (AD), in particular by the International Genomics of Alzheimer’s Project (IGAP), the European Alzheimer & Dementia Biobank (EADB), and the Psychiatric Genomics Consortium (PGC). Those genome‐wide association studies (GWAS) showed that increasing the sample size and performing imputation using the largest reference panel available greatly improves statistical power to detect genetic associations with AD. In order to better characterize the genetic architecture and pathophysiology underlying this

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Joshi, Himanshu, Ashika Anne Roy, Setu Havanur, et al. "The role of transcranial direct current stimulation in improving learning and memory performances of patients with mild cognitive impairment and mild Alzheimer’s disease: a functional magnetic resonance imaging study." Alzheimer's & Dementia 19, S16 (2023). http://dx.doi.org/10.1002/alz.076719.

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AbstractBackgroundTranscranial direct current stimulation (tDCS) is a safe non‐invasive brain stimulation (NIBS) procedure which helps to stimulate a particular region of interest by modulating the neuronal firing rate, thereby modulating the cognitive functioning. The tDCS intervention is known to show improvement on memory recall and recognition in patients with mild cognitive impairment (MCI) and mild Alzheimer’s Disease (mild AD)MethodWe investigated the effect of anodal stimulation at the left dorsolateral prefrontal cortex (DLPFC) and cathodal stimulation at the right supra‐orbital area

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Restrepo-Lozano, Jose M., Irina Pokhvisneva, Zihan Wang, et al. "Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children." Molecular Psychiatry, April 7, 2022. http://dx.doi.org/10.1038/s41380-022-01533-7.

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AbstractInhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The communication- as well as the connectivity- between corticolimbic regions of the brain are fundamental for eliciting inhibitory control behaviors, but early markers of vulnerability to this behavioral trait are yet to be discovered. The gradual maturation of the prefrontal cortex (PFC), in particular of the mesocortical dopamine innervation, mirrors the protracted development of inhibitory control; both are present early in life, but reach full maturation by early adulthood. Evidence suggests the inv

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Jeon, So Yeon, Dahyun Yi, Min Soo Byun, et al. "In vivo tau deposition in the brain stem nuclei and circadian rest‐activity rhythm change in non‐demented older adults." Alzheimer's & Dementia 19, S16 (2023). http://dx.doi.org/10.1002/alz.072754.

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Abstract:

AbstractBackgroundCircadian rest‐activity rhythm (RAR) alterations are common in the early stage of Alzheimer’s disease (AD) disease. Given that the brainstem nuclei, the locus coeruleus (LC) and dorsal raphe nucleus (DRN) in particular, play key roles in modulating arousal and the sleep‐wake cycle, tau pathology in the brain stem nuclei, which occurs even before cortical tau progression, may relate to circadian RAR alteration in older individuals. Therefore, we aimed to test the hypothesis that in vivo tau deposition in the LC and DRN correlates with circadian RAR in non‐demented older adults

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Jeon, So Yeon, Dahyun Yi, Min Soo Byun, et al. "In vivo tau deposition in the brain stem nuclei and circadian rest‐activity rhythm change in non‐demented older adults." Alzheimer's & Dementia 19, S10 (2023). http://dx.doi.org/10.1002/alz.081600.

Full text

Abstract:

AbstractBackgroundCircadian rest‐activity rhythm (RAR) alterations are common in the early stage of Alzheimer’s disease (AD) disease. Given that the brainstem nuclei, the locus coeruleus (LC) and dorsal raphe nucleus (DRN) in particular, play key roles in modulating arousal and the sleep‐wake cycle, tau pathology in the brain stem nuclei, which occurs even before cortical tau progression, may relate to circadian RAR alteration in older individuals. Therefore, we aimed to test the hypothesis that in vivo tau deposition in the LC and DRN correlates with circadian RAR in non‐demented older adults

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