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Relevant bibliographies by topics / Passive / active targeting

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Academic literature on the topic 'Passive / active targeting'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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Journal articles on the topic "Passive / active targeting"

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Sharad, Dhotre*1 Achal Dhotre2 Siddhesh Aher3 Kartiki Deshmukh4 Ishika Dargude5. "Targeted Nanoparticle-Based Drug Delivery Systems: Enhancing Therapeutic Efficacy in Cancer Treatment." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1811–23. https://doi.org/10.5281/zenodo.14909024.

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Cancer remains a significant cause of illness and death globally, regardless of the level of human development. One key strategy in cancer treatment is the targeted delivery of drugs directly to tumor sites. Recent advancements in nanotechnology have opened new avenues for researchers to enhance cancer therapies. Nanoparticles are defined as particles with a size smaller than 0.1 µm, or 100 nm. They play a crucial role in improving the delivery and uptake of medications in targeted cells. There are two primary methods for synthesizing nanoparticles: the bottom-up method and the top-down

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Sharad, Dhotre*1 Achal Dhotre2 Siddhesh Aher3 Kartiki Deshmukh4 Ishika Dargude5. "Targeted Nanoparticle-Based Drug Delivery Systems: Enhancing Therapeutic Efficacy in Cancer Treatment." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1937–49. https://doi.org/10.5281/zenodo.14918325.

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Cancer remains a significant cause of illness and death globally, regardless of the level of human development. One key strategy in cancer treatment is the targeted delivery of drugs directly to tumor sites. Recent advancements in nanotechnology have opened new avenues for researchers to enhance cancer therapies. Nanoparticles are defined as particles with a size smaller than 0.1 µm, or 100 nm. They play a crucial role in improving the delivery and uptake of medications in targeted cells. There are two primary methods for synthesizing nanoparticles: the bottom-up method and the top-down

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Hirsjarvi, Samuli, Catherine Passirani, and Jean-Pierre Benoit. "Passive and Active Tumour Targeting with Nanocarriers." Current Drug Discovery Technologies 8, no. 3 (2011): 188–96. http://dx.doi.org/10.2174/157016311796798991.

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Daljeet, Singh Manhas. "PASSIVE AND ACTIVE TUMOR TARGETING OF NANO CARRIERS FOR ANTI-CANCER DRUG DELIVERY- A REVIEW." iajps,csk publications 03, no. 11 (2016): 1345–49. https://doi.org/10.5281/zenodo.195190.

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<em>Because of the particular characteristics of the tumor microenvironment and tumor angiogenesis, it is possible to design drug delivery systems that specifically target anti-cancer drugs to tumors. Most of the conventional chemotherapeutic agents have poor pharmacokinetics profiles and are distributed non-specifically in the body leading to systemic toxicity associated with serious side effects. Therefore, the development of drug delivery systems able to target the tumor site is becoming a real challenge that is currently addressed. Nanomedicine can reach tumor passively through the leaky v

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Li, Jianmin, Qingluo Wang, Guoyu Xia, et al. "Recent Advances in Targeted Drug Delivery Strategy for Enhancing Oncotherapy." Pharmaceutics 15, no. 9 (2023): 2233. http://dx.doi.org/10.3390/pharmaceutics15092233.

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Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile, weaken their undesirable side effects on normal cells or tissues. In this research field, a large number of researchers have achieved significant breakthroughs and advances in oncotherapy. Typically, nanocarriers as a promising drug delivery strategy can effectively deliver drugs to the tumor site through enhanced permeability and retention (EPR) effect-mediated passive targeting and various types of receptor-m

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Pandya, Tosha, Kaushika Kaushika Patel, Rudree Pathak, and Shreeraj Shah. "Liposomal Formulations In Cancer Therapy: Passive Versus Active Targeting." Asian Journal of Pharmaceutical Research and Development 7, no. 2 (2019): 35–38. http://dx.doi.org/10.22270/ajprd.v7i2.489.

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In Cancer therapy, Nano drug delivery system comprising of Liposomes, are the most successful mode of treatment in present scenario which also has real time clinical application. Recently it is found that the closed bilayer phospholipid vesicles have many technical advantages over the initially used liposomal formulations. The delivery of therapeutics encapsulated in liposomes changes the biological distribution profile and improves the drug therapeutic indices of various drugs. This review article throws light onto many clinical liposomal drug delivery products. The liposome Nano drug deliver

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Sharma, Rama. "Nanotechnology: A Way for Active Targeting of Cancer Cells." Research Journal of Biotechnology 20, no. 2 (2024): 222–27. https://doi.org/10.25303/202rjbt2220227.

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Since cancer is one of the top causes of death, researchers have been working hard for cancer management. Creating drugs that can be utilized for both early detection and efficient treatment, is one of the most challenging parts of cancer treatment. Traditional cancer treatment is linked with a high risk of serious chemotherapeutic side effects and occasionally lacks precise technology for early tumour identification. It was thought that a medication that could serve as a "magic bullet" and could only recognize cancer cells, was required for better therapeutic ratio, defined as the distinction

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Mathur, Rashi, Narmada Bag, Raunak Varshney, et al. "Enhanced in vivo tumour imaging by EDTA-bis-GNGR functionalized core shell CdSe:ZnS quantum dot: synergistic effect of active passive targeting." RSC Advances 6, no. 16 (2016): 13562–71. http://dx.doi.org/10.1039/c5ra22989h.

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Lee, Hyeonah, and Hyeran Noh. "Advancements in Nanogels for Enhanced Ocular Drug Delivery: Cutting-Edge Strategies to Overcome Eye Barriers." Gels 9, no. 9 (2023): 718. http://dx.doi.org/10.3390/gels9090718.

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Nanomedicine in gel or particle formation holds considerable potential for enhancing passive and active targeting within ocular drug delivery systems. The complex barriers of the eye, exemplified by the intricate network of closely connected tissue structures, pose significant challenges for drug administration. Leveraging the capability of engineered nanomedicine offers a promising approach to enhance drug penetration, particularly through active targeting agents such as protein peptides and aptamers, which facilitate targeted release and heightened bioavailability. Simultaneously, DNA carrie

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Ouyang, Ancheng, Dongmu Zhao, Xianglei Wang, et al. "Covalent RGD–graphene–phthalocyanine nanocomposite for fluorescence imaging-guided dual active/passive tumor-targeted combinatorial phototherapy." Journal of Materials Chemistry B 10, no. 2 (2022): 306–20. http://dx.doi.org/10.1039/d1tb02254g.

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Dissertations / Theses on the topic "Passive / active targeting"

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Senior, Judith Helen. "Liposomes in drug delivery : site-directed approaches using active and passive targeting." Thesis, University College London (University of London), 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261677.

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Attia, Mohamed. "Contrast agent based on nano-emulsion for targeted biomedical imaging." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF043.

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Les agents d’imagerie aux rayons X sont essentiels en combinaison avec la tomodensitométrie pour améliorer le contraste de manière à permettre la visualisation complète des vaisseaux sanguins et de fournir l'information structurelle et fonctionnelle de lésions permettant la détection d'une tumeur. Ces outils fondamentaux permettent également de faire la distinction entre les cellules et les agents pathogènes sains. Les agents de contraste aux rayons X commercialisés sont limités dans leur succès dans le cas du Fenestra® VC par le temps court de circulation dans le sang et celui qui est lié à l

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Diou, Odile. "Synthèse de nanocapsules polymères pour la détection de tumeurs solides par échographie et IRM du Fluor : vers un outil théranostique." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00907145.

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Le cancer est un problème de santé publique dans le monde entier et d'importantes ressources en soins de santé sont dépensées pour le diagnostic. Plus précoce sera le dépistage des tumeurs, meilleures sont les chances de rémission sans rechute. Les techniques d'imagerie permettent de suivre l'évolution du traitement et de réorienter la stratégie en cas d'échec. En combinaison avec des agents de contraste ciblés, les modalités d'imagerie permettent même de sonder les structures à l'échelle moléculaires ce qui pourrait laisser envisager un traitement personnalisé du cancer [1, 2]. L'imagerie par

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Dai, You-Shan, and 戴攸珊. "Passive and active targeting of silibinin-loaded nanocarriers for treating hepatic fibrosis." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/95511343635112422385.

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Ho, Karyn. "Targeted Drug Delivery to Breast Cancer using Polymeric Nanoparticle Micelles." Thesis, 2012. http://hdl.handle.net/1807/34054.

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Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable systemic toxicity and narrow therapeutic indices. To improve tumour accumulation, drug-loaded macromolecular assemblies have been designed to replace conventional surfactant-based formulations. Their nanoscale size enhances tumour accumulation via hyperpermeable vasculature and reduced lymphatic drainage. Incorporating targeting ligands introduces cell specificity through receptor-specific binding and uptake, enabling drugs to reach intracellular targets. In this work, the targeting propertie

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Pereira, Ana Filipa Fernandes. "Nanossistemas usados em tumores." Master's thesis, 2014. http://hdl.handle.net/10451/25731.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Esta monografia tem por objectivo fazer uma revisão geral sobre o que se passa actualmente no combate a tumores recorrendo a nanossitemas, Como já é amplamente sabido os nanossistemas são úteis no combate a tumores, bem como no diagnóstico e monotorização dos mesmos. O facto dos tecidos tumorais terem características muito diferentes das características dos tecidos normais permite-nos, através da utilização de nanossistemas, garantir que o fármaco atinge o tumor com mais eficác

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Books on the topic "Passive / active targeting"

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Lerner, Ross. Unknowing Fanaticism. Fordham University Press, 2019. http://dx.doi.org/10.5422/fordham/9780823283873.001.0001.

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We may think we know what defines religious fanaticism: violent action undertaken with dogmatic certainty. But the term “fanatic,” from the European Reformation to today, has never been a stable term. Then and now it has been reductively defined to justify state violence and to delegitimize alternative sources of authority. Unknowing Fanaticism rejects the simplified binary of fanatical religion and rational politics and turns to Renaissance literature to demonstrate that fanaticism was integral to how both modern politics and poetics developed, from the German Peasant Revolts of the 1520s to

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Book chapters on the topic "Passive / active targeting"

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Hefnawy, Amr, and Ibrahim M. El-Sherbiny. "Passive and Active Targeting of Brain Tumors." In Neuromethods. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-1052-7_2.

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More, Mahesh P., Prashant K. Deshmukh, Pravin O. Patil, et al. "Passive and Active Targeting for Solid Tumors." In Environmental Chemistry for a Sustainable World. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14848-4_5.

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Torchilin, Vladimir P. "Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example." In Drug Delivery. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00477-3_1.

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Upponi, Jaydev R., and Vladimir P. Torchilin. "Passive vs. Active Targeting: An Update of the EPR Role in Drug Delivery to Tumors." In Nano-Oncologicals. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-08084-0_1.

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Gdonteli, Krinanthi, Pinelopi Athanasopoulou, and Nikos Papaiakovou. "Using Social Media as a Marketing Tool in Sport Tourism Firms." In Strategic Innovative Marketing and Tourism. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-51038-0_78.

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AbstractThe purpose of this study is to investigate the use of Social Media (SM) as a marketing tool by Greek sport tourism businesses at each stage of the consumer decision making process. Specifically three stages are analyzed, before, during, and after the consumption experience. In total, 20 interviews were conducted with managers of Sport Tourism businesses using a semi-structured questionnaire. The sample was split into two groups, 6 companies that have scientific knowledge of marketing and use it in their strategy (A Group) and 14 firms that treat marketing as a supplementary process that is not very important (B Group). Data was analyzed based on this categorization by using content analysis. Results show that Group A have a specific marketing strategy that includes the strategic use of social media for segmentation, targeting and positioning whereas group B have a passive strategy in the market and wait for customers to come to them. There is no active segmentation, targeting and positioning and they expect the Greek Tourism Organization to promote sport tourism activities. Results show that sport tourism businesses need to use social media strategically in all stages of the consumer decision making process and recruit specialized staff that will handle a social media marketing strategy. Future research can extend the sample, use quantitative methodologies, research different sport tourism activities or events or different types of customers.

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Zafaryab, Mohammad, and Komal Vig. "Nanogels for active and passive targeting and delivery." In Nanogels. Elsevier, 2025. https://doi.org/10.1016/b978-0-443-30016-5.00013-6.

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Balyapan, Hande, and Güliz Ak. "Nanoparticle Targeting Strategies In Cancer Therapy." In Recent Progress in Pharmaceutical Nanobiotechnology: A Medical Perspective. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815179422123080010.

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This review outlines major cancer targeting strategies for nanoparticle systems. Targeted therapies have superiority over conventional chemotherapy or radiotherapy methods. Nanoparticles as drug nanocarriers enable drug delivery to the tumoral regions. For targeted drug delivery, nanoparticles are designed and tailored depending on the cancer and the purpose of the targeting mechanism. In this review, nanoparticle targeting for cancer therapy was summarized into three sections: passive, active, and physical targeting. Each issue was described and discussed with recent nanoparticular studies and their findings. In addition, a combination of targeting with diagnostics and theranostics was also presented.

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Ghosh, Miltu Kumar, and Falguni Patra. "Passive and Active Tumor Targeting of Polysaccharide Nanocarriers for Cancer Therapy." In Polysaccharide-based Nano-Biocarrier in Drug Delivery. CRC Press, 2018. http://dx.doi.org/10.1201/9780429449437-16.

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Singh, Akashdeep, and Vikas Rana. "Ligands for Tumor Targeting." In Role of Nanotechnology in Cancer Therapy. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079999123010008.

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Cancer is the world's second leading cause of death, and new cancer cases are expected to increase dramatically in the next decades. Many biotechnologists and medical researchers are actively involved in finding issues related to cancer detection and treatment efficacy. Given the difficulties of traditional chemotherapy, the targeted drug delivery system (DDS) of chemotherapeutics for cancer therapy through nanoparticles (NPs) carriers is a growing field of research. Researchers have concentrated on surface modification of NPs or nanocarriers using biological ligands in addition to optimizing their physicochemical characteristics. Several in-vivo investigations have shown that virus-sized stealth NPs may circulate in the blood for a longer period and preferentially concentrate at tumor sites due to the increased permeability and retention (EPR) effect, also known as the passive targeting strategy. Surface modification of stealth NPs with specific biological ligands may result in enhanced retention and accumulation of NPs in tumor sites, referred to as an “active targeting strategy”. This chapter outlined some key points regarding each strategy's impact and how combining some or all of them has proven beneficial in tumor targeting. After a brief introduction to existing cancer treatments and their drawbacks, we discussed the biological obstacles that NPs must overcome, followed by several forms of DDS to increase drug accumulation in the tumor site. Then, using active targeting strategies, we also describe various receptors present on cancer cells that enhance cellular drug targeting. A substantial quantity of information has been summarized in tables on different polymeric NPs conjugated with selective targeting ligands such as proteins, polysaccharides, peptides, and aptamers to small molecules. With the potential of maximizing therapeutic efficacy and reducing side effects, ligand.mediated-DDS has emerged as an essential platform for safe and effective tumor treatment.

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Mishra, Neelam, Mihar S. Shaikh, Kinjal D. Solanki, Ashwini M. Savle, Fanny Coumes, and Yogesh K. Kadam. "Nanotechnology in Cancer Therapy." In Advances in Chemical and Materials Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-6326-3.ch019.

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In the field of cancer research, nanotechnology holds tremendous potential for improving therapy efficacy while maintaining treatment safety and opening up new avenues for the development of targeted and customized medications. Numerous uses of nanomaterials have been reported in cancer therapy, including gene therapy, drug resistance, immunotherapy, tumor microenvironment modification, imaging, diagnostics, and cancer vaccine administration. To guarantee that medications are delivered precisely to cancer cells, effective targeted drug delivery systems (TDDS) rely on a number of techniques, including stimuli-responsive targeting, passive targeting and active targeting. Numerous leading-edge delivery methods are being developed for nano pharmaceuticals, which have emerged as a promising therapy option for cancer. To fully achieve its promise, obstacles including toxicity and biocompatibility, manufacturing and scalability, regulatory approval and targeting still need to be addressed.

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Conference papers on the topic "Passive / active targeting"

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Perera, Reshani, Al De Leon, Xinning Wang, et al. "Nanobubble Extravasation in Prostate Tumors Imaged with Ultrasound: Role of Active versus Passive Targeting." In 2018 IEEE International Ultrasonics Symposium (IUS). IEEE, 2018. http://dx.doi.org/10.1109/ultsym.2018.8580221.

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Watanabe, Kota, Nanako Miura, and Akira Sone. "Development of Active Vibration Damping Device Adjusting TMD to Various Periodic Bands of Seismic Waves." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93780.

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Abstract There are many high-rise buildings all over the world, especially urban areas. Their usage is diverse, such as offices and residences. Therefore, earthquake countermeasures for high-rise buildings are indispensable. It is known that a tuned mass damper (TMD), which is mainly installed for countermeasures against wind shaking, does not show sufficient damping effect when large earthquake occurs or when higher modes vibration is excited. In addition, when exceeding the drive limit of the TMD in resonance, the TMD may collide against the stopper and deteriorate the response of the buildi

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Tse, Zion Tsz Ho, Sheng Xu, Alexander Squires, et al. "Robot for MRI-Guided Prostate Cancer Focal Laser Ablation." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3511.

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Prostate cancer is the most common cancer among males, leading to approximately 27,000 deaths in the United States [1]. Focal laser ablation (FLA) has been shown to be a promising approach for prostate cancer treatment with the advantage of efficiently ablating the cancer cells while inflicting less damage on the surrounding tissues. In current FLA procedures, a rigid template — with holes spacing of 5mm — guides the FLA catheter to the target position. Drawbacks of the conventional approach for catheter targeting are 1) limited degrees of freedom (DoF) and 2) a low insertion resolution. In ad

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Kim, Doyoung, Tarun K. Podder, and Parsaoran Hutapea. "Investigation of Pre-Bent and Pre-Curved Needles Interacting With Soft Tissue Materials." In ASME 2024 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2024. https://doi.org/10.1115/imece2024-143461.

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Abstract Precise needle insertion is crucial in minimally invasive procedures such as brachytherapy, biopsy, and drug delivery, directly impacting clinical outcomes. Several factors affect needle positioning accuracy, including insertion force, tissue deformation, and obstacles along the trajectory. Techniques to activate needles to bend during insertion are being developed to create curved paths and avoid obstacles for targeting accuracy. However, the interaction between bent or curved needles and soft tissues has yet to be studied extensively. This study uses passive needles to understand ac

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Acharya, Sharad Raj, and Parsaoran Hutapea. "Design and Control Strategy of Tip Manipulation for Shape Memory Alloy Actuated Steerable Needle." In ASME 2022 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/smasis2022-91002.

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Abstract In a minimally invasive percutaneous procedure like biopsy, brachytherapy, and tissue ablation, the inner soft tissue is accessed through surgical needle-puncture of the skin. This process reduces tissue damage and risk of infection and improves patient recovery time. However, its effectiveness depends on the needle’s ability to travel on a curved path, avoid obstacles, and maintain high targeting accuracy. Conventional needles are passive and have limited steerability and trajectory correction capability. This has motivated researchers to develop actuation mechanisms to create active

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Tsamis, Alexandros, Theodorian Borca-Tascuic, and Youngjin Hwang. "An Ectothermic Approach to Heating and Cooling in Buildings." In 2020 ACSA Fall Conference. ACSA Press, 2020. http://dx.doi.org/10.35483/acsa.aia.fallintercarbon.20.31.

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The built environment is responsible for nearly 40% of global energy use, significantly contributing to carbon emissions. Targeting a carbon-negative future would require a rethinking of the way we heat and cool buildings, distancing ourselves from the predominant model for the building envelope as a boundary that excludes the weather and instead adopting alternatives that transform the building envelope to a mediator that actively regulates heat exchange. In this paper, we explore the potential for a building boundary that actively heats and cools a building by forming dynamic relationships w

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Wullems, Christian, and Anjum Naweed. "Low-Cost Railway Level Crossings: Breaking Down the Barriers." In 2014 Joint Rail Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/jrc2014-3808.

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Level crossing risk continues to be a significant safety concern for the security of rail operations around the world. Over the last decade or so, a third of railway related fatalities occurred as a direct result of collisions between road and rail vehicles in Australia. Importantly, nearly half of these collisions occurred at railway level crossings with no active protection, such as flashing lights or boom barriers. Current practice is to upgrade level crossings that have no active protection. However, the total number of level crossings found across Australia exceed 23,500, and targeting th

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Krishnababu, Senthil, Giuseppe Bruni, and Agnieszka Frach. "On the Forced Response Predictions and Life Improvements of an Industrial Axial Compressor Rotor Blade." In ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/gt2021-58923.

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Abstract Improvements made to the high cycle fatigue life of an industrial compressor rotor blade for tip active modes through aerodynamic design changes and aero-mechanical assessments are presented in this paper. Typical aero-mechanical computations involved utilising an in-house linear-harmonic solver to compute the aero damping. In parallel, a novel hybrid model with whole-anulus domain for the blade rows of interest followed by a single passage domain for the rest of the compressor was used to compute the modal forcing. In addition to the standard blade passing resonances, low engine orde

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Zhao, Shujie, Zhen Gao, Dejiang Li, and Xun Meng. "Dynamic Property of a Floating Multi-Body System for Dual Barge Float-Over Operation With a Mechanical TLS (Topside Lifting System)." In ASME 2022 41st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/omae2022-78400.

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Abstract TLS (Topsides Lifting System) utilization is a modern fast lifting technology developed for offshore platform installation. The positive prospects have seen from its sound and efficient performance at the offshore operation. To improve the feasibility of dual barge float-over operations, two new individual barges are designed in application with TLS. The targeting TLS system is equipped with motion compensation system that consists of several sets of lifting beams. Because the flexible mechanical couplings and the hydrodynamic interactions between bodies, the dynamic characteristics o

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