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Relevant bibliographies by topics / Patch-clamp electrophysiology

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Academic literature on the topic 'Patch-clamp electrophysiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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Journal articles on the topic "Patch-clamp electrophysiology"

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Kusch, Jana, and Giovanni Zifarelli. "Patch-Clamp Fluorometry: Electrophysiology meets Fluorescence." Biophysical Journal 106, no. 6 (March 2014): 1250–57. http://dx.doi.org/10.1016/j.bpj.2014.02.006.

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Annecchino, Luca A., and Simon R. Schultz. "Progress in automating patch clamp cellular physiology." Brain and Neuroscience Advances 2 (January 1, 2018): 239821281877656. http://dx.doi.org/10.1177/2398212818776561.

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Patch clamp electrophysiology has transformed research in the life sciences over the last few decades. Since their inception, automatic patch clamp platforms have evolved considerably, demonstrating the capability to address both voltage- and ligand-gated channels, and showing the potential to play a pivotal role in drug discovery and biomedical research. Unfortunately, the cell suspension assays to which early systems were limited cannot recreate biologically relevant cellular environments, or capture higher order aspects of synaptic physiology and network dynamics. In vivo patch clamp electrophysiology has the potential to yield more biologically complex information and be especially useful in reverse engineering the molecular and cellular mechanisms of single-cell and network neuronal computation, while capturing important aspects of human disease mechanisms and possible therapeutic strategies. Unfortunately, it is a difficult procedure with a steep learning curve, which has restricted dissemination of the technique. Luckily, in vivo patch clamp electrophysiology seems particularly amenable to robotic automation. In this review, we document the development of automated patch clamp technology, from early systems based on multi-well plates through to automated planar-array platforms, and modern robotic platforms capable of performing two-photon targeted whole-cell electrophysiological recordings in vivo.

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Mak, Don-On Daniel, Horia Vais, King-Ho Cheung, and J. Kevin Foskett. "Patch-Clamp Electrophysiology of Intracellular Ca2+Channels." Cold Spring Harbor Protocols 2013, no. 9 (September 2013): pdb.top066217. http://dx.doi.org/10.1101/pdb.top066217.

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Mak, Don-On Daniel, Horia Vais, King-Ho Cheung, and J. Kevin Foskett. "Nuclear Patch-Clamp Electrophysiology of Ca 2+ Channels." Cold Spring Harbor Protocols 2013, no. 9 (September 2013): pdb.prot073064. http://dx.doi.org/10.1101/pdb.prot073064.

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John, Victoria H., Tim J. Dale, Emma C. Hollands, Mao Xiang Chen, Leanne Partington, David L. Downie, Helen J. Meadows, and Derek J. Trezise. "Novel 384-Well Population Patch Clamp Electrophysiology Assays for Ca2+-Activated K+ Channels." Journal of Biomolecular Screening 12, no. 1 (November 12, 2006): 50–60. http://dx.doi.org/10.1177/1087057106294920.

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Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels. In CHO-hIK—expressing cells, under asymmetric K+ gradients, small-molecule channel activators evoked time- and voltage-independent currents characteristic of those previously described by classical patch clamp electrophysiology methods. In single-hole (cell) experiments, the large cell-to-cell heterogeneity in channel expression rendered it difficult to generate activator concentration-response curves. However, in population patch clamp mode, in which signals are averaged from up to 64 cells, well-to-well variation was substantially reduced such that concentration-response curves could be easily constructed. The absolute EC50 values and rank order of potency for a range of activators, including 1-EBIO and DC-EBIO, corresponded well with conventional patch clamp data. Activator responses of hIK and hSK3 channels could be fully and specifically blocked by the selective inhibitors TRAM-34 and apamin, with IC50 values of 0.31 μM and 3 nM, respectively. To demonstrate assay precision and robustness, a test set of 704 compounds was screened in a 384-well format of the hIK assay. All plates had Z′ values greater than 0.6, and the statistical cutoff for activity was 8%. Eleven hits (1.6%) were identified from this set, in addition to the randomly spiked wells with known activators. Overall, our findings demonstrate that population patch clamp is a powerful and enabling method for screening Ca2+-activated K+ channels and provides significant advantages over single-cell electrophysiology (IonWorksHT) and other previously published approaches. Moreover, this work demonstrates for the 1st time the utility of population patch clamp for ion channel activator assays and for non—voltage-gated ion channels.

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Fernandez-Chiappe, Florencia, and Nara I. Muraro. "Patch-Clamping Fly Brain Neurons." Cold Spring Harbor Protocols 2022, no. 8 (July 7, 2022): pdb.top107796. http://dx.doi.org/10.1101/pdb.top107796.

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The membrane potential of excitable cells, such as neurons and muscle cells, experiences a rich repertoire of dynamic changes mediated by an array of ligand- and voltage-gated ion channels. Central neurons, in particular, are fantastic computators of information, sensing, and integrating multiple subthreshold currents mediated by synaptic inputs and translating them into action potential patterns. Electrophysiology comprises a group of techniques that allow the direct measurement of electrical signals. There are many different electrophysiological approaches, but, because Drosophila neurons are small, the whole-cell patch-clamp technique is the only applicable method for recording electrical signals from individual central neurons. Here, we provide background on patch-clamp electrophysiology in Drosophila and introduce protocols for dissecting larval and adult brains, as well as for achieving whole-cell patch-clamp recordings of identified neuronal types. Patch clamping is a labor-intensive technique that requires a great deal of practice to become an expert; therefore, a steep learning curve should be anticipated. However, the instant gratification of neuronal spiking is an experience that we wish to share and disseminate, as many more Drosophila patch clampers are needed to study the electrical features of so many fly neuronal types unknown to date.

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Dai, Shanshan, and Jacob K. Rosenstein. "A 15-V Bidirectional Current Clamp Circuit for Integrated Patch Clamp Electrophysiology." IEEE Transactions on Circuits and Systems II: Express Briefs 64, no. 11 (November 2017): 1287–91. http://dx.doi.org/10.1109/tcsii.2017.2647899.

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Robinson, Tim, Lars Thomsen, and Jan D. Huizinga. "LabPatch, an acquisition and analysis program for patch-clamp electrophysiology." American Journal of Physiology-Cell Physiology 278, no. 5 (May 1, 2000): C1055—C1061. http://dx.doi.org/10.1152/ajpcell.2000.278.5.c1055.

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An acquisition and analysis program, “LabPatch,” has been developed for use in patch-clamp research. LabPatch controls any patch-clamp amplifier, acquires and records data, runs voltage protocols, plots and analyzes data, and connects to spreadsheet and database programs. Controls within LabPatch are grouped by function on one screen, much like an oscilloscope front panel. The software is mouse driven, so that the user need only point and click. Finally, the ability to copy data to other programs running in Windows 95/98, and the ability to keep track of experiments using a database, make LabPatch extremely versatile. The system requirements include Windows 95/98, at least a 100-MHz processor and 16 MB RAM, a data acquisition card, digital-to-analog converter, and a patch-clamp amplifier. LabPatch is available free of charge at http://www.fhs.mcmaster.ca/huizinga/ .

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Dos Santos-Nascimento, Tiago, Kleyane Morais Veras, José Ossian Almeida Souza-Filho, and Luiz Moreira-Júnior. "Electrophysiology study using patch clamp technique in sensory neurons." Brazilian Journal of Case Reports 1, no. 1 (March 31, 2021): 12–14. http://dx.doi.org/10.52600/2763-583x.bjcr.2021.1.1.12-14.

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The electrophysiological and pharmacological study involving sensory and autonomic neurons enables the development of new effective agents in the treatment of neuropathic disorders, since they enable the elucidation of the mechanisms underlying the malfunction of the nervous system. In this context, the patch clamp technique increased the study of cells, providing a high-resolution method at the molecular level for observing the flow of ions through ion channels characteristic of excitable cells [1], such as the neurons. When using different protocols with combinations of intracellular and extracellular solutions with specific pharmacological agents, this technique allows different unit and/or macroscopic records of active and passive electrical variables of cellular activity [2] that it favored the Nobel Prize in physiology or medicine to Erwin Neher and Bert Sakmann in 1991. Although the whole cell mode is the most used configuration in health-related researches, little is known in health courses. To apply this technique to neurons, it is commonly necessary to dissociate neurossomas. Figure 01 shows sensory neurossome of the dorsal root ganglion (GRD) of rats from the bioterium of the State University of Ceará (CEUA process number 10339956-9). The process of isolating neurossomas from the intact ganglion consists of two phases: 1) Collagenase (1mg / ml for 75 min) and Trypsin + EDTA (0.25% and 0.025%, respectively, for 12 minutes); 2) Mechanical dispersion with 3 Pasteur glass pipettes with decreasing diameter (2.5 mm, 1 mm and 0.5 mm, respectively). Then, the neurossomas were plated on coverslips previously treated with poly-D-lysine maintained in supplemented DMEM and incubated at 37 °C and 5% CO2 [3]. The figure shows a neurossoma 24h after plating. This cell has approximately 25 µM in diameter, which it plays role nociception function [4]. Furthermore, the nucleus is not centralized, the cell does not have neurites. As for the micropipette, capillaries were used for micro-hematocrit without heparin (75 mm length, 1 mm inner diameter and 1.5 mm outer diameter) for making with tip resistance range from 1 and 3 MΩ after filling with the solution to compose intracellular medium [5]. In this technique, a microelectrode was micrometrically move toward until it lightly touched the plasma membrane. Then, a continuous negative pressure was applied to increase the contact of the glass with the membrane, stabilizing the seal (interaction between membrane and glass) and increasing it until its resistance reaches the order of 109 ohm (GΩ). Then, more suction was applied to cause the cell surface under the microelectrode to rupture, thus providing access to the interior of the cell, allowing excellent control of the cell membrane potential and, consequently, high-fidelity records of ionic currents that flow through ion channels present in the plasma membrane of neurossomas.

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Li, B. Y., and J. H. Schild. "Patch clamp electrophysiology in nodose ganglia of adult rat." Journal of Neuroscience Methods 115, no. 2 (April 2002): 157–67. http://dx.doi.org/10.1016/s0165-0270(02)00010-9.

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Dissertations / Theses on the topic "Patch-clamp electrophysiology"

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Matthews, Brian. "Micromachined planar patch-clamp system for electrophysiology research." Diss., Restricted to subscribing institutions, 2006. http://proquest.umi.com/pqdweb?did=1188879521&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Squire-Pollard, Laura G. "A patch-clamp study of membrane ion channels in exocrine acinar cells." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316552.

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Dargan, Sheila Louise. "Patch-clamp studies of single type-1 Ins(1,4,5)P3 receptor channels." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393131.

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Mansell, Steven A. "The characterisation of ion channels in human spermatozoa by whole cell patch clamp electrophysiology." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/5fc0b4d5-ac64-474d-9cf3-5a123fa665cb.

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Kodandaramaiah, Suhasa Bangalore. "Robotics for in vivo whole cell patch clamping." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51932.

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Whole-cell patch clamp electrophysiology of neurons in vivo enables the recording of electrical events in cells with great precision, and supports a wide diversity of morphological and molecular analysis experiments important for the understanding of single-cell and network functions in the intact brain. However, high levels of skill are required in order to perform in vivo patching, and the process is time-consuming and painstaking. Robotic systems for in vivo patching would not only empower a great number of neuroscientists to perform such experiments, but would also open up fundamentally new kinds of experiment enabled by the resultant high throughput and scalability. We discovered that in vivo blind whole cell patch clamp electrophysiology could be implemented as a straightforward algorithm and developed an automated robotic system that was capable of performing this algorithm. We validated the performance of the robot in both the cortex and hippocampus of anesthetized mice. The robot achieves yields, cell recording qualities, and operational speeds that are comparable to, or exceed, those of experienced human investigators. Building upon this framework, we developed a multichannel version of “autopatcher” robot capable establishing whole cell patch clamp recordings from pairs and triplets of neurons in the cortex simultaneously. These algorithms can be generalized to control arbitrarily large number of electrodes and the high yield, throughput and automation of complex set of tasks results in a practical solution for conducting patch clamp recordings in potentially dozens of interconnected neurons in vivo.

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Appenrodt, Peter. "Single-channel recordings of potassium channels from guinea-pig inner hair cells." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390054.

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Tessier, Christian. "Dissecting Kinetic Differences in Acetylcholine Receptors Incorporating an Ancestral Subunit." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38868.

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At the neuromuscular junction, nicotinic acetylcholine receptors (AChRs) convert chemical stimuli into electrical signals. They are heteropentameric membrane protein complexes assembled from four evolutionary related subunits (two α subunits, and one each of the β-, δ-, and ε-subunits), arranged around a central ion-conducting pore, which is regulated by the neurotransmitter acetylcholine. Understanding how the binding of acetylcholine leads to channel opening is of fundamental importance. While it is known that channel opening results from a global conformational change involving the cooperative action of all five subunits, how the subunits achieve this cooperativity is unclear. Our hypothesis is that this subunit cooperation is maintained through coevolution of the subunits, and thus studies of subunit coevolution can provide insight into subunit cooperativity. Using an ancestral reconstruction approach, combined with single-molecule patch clamp electrophysiology, we have begun dissecting the mechanistic consequences of preventing coevolution of the acetylcholine receptor β-subunit. This approach has allowed us to identify new amino acid determinants of acetylcholine receptor function.

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FLANNERY, RICHARD JOHN. "CLUSTERING OF CYCLIC-NUCLEOTIDE-GATED CHANNELS IN OLFACTORY CILIA." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1136913935.

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Immonen, E. V. (Esa-Ville). "In vitro electrophysiology of photoreceptors of two nocturnal insect species, Periplaneta americana and Gryllus bimaculatus." Doctoral thesis, University of Oulu, 2014. http://urn.fi/urn:isbn:9789526206479.

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Abstract In dim light, reliable coding of visual information becomes compromised, unless the sensitivity of the visual system to light is improved by structural and functional adaptations. Thus far, many adaptations for night vision in the compound eyes of nocturnal insects have been described, but little is known about the mechanisms underlying the electrochemical signalling in their photoreceptors. In this thesis, whole-cell patch-clamp and mathematical modelling are utilised to study basic electrical properties and ionic currents in photoreceptors of two nocturnal insects, the American cockroach Periplaneta americana and the field cricket Gryllus bimaculatus. Photoreceptors in both species showed large input resistance, membrane capacitance and phototransduction gain (large single photon responses) compared with most studied diurnal insects, providing improved sensitivity to light. The photoreceptors also expressed two voltage-sensitive outward currents: a transient current and a sustained current. The cricket photoreceptor expressed a dominating transient current, which is a typical characteristic for insects adapted for slow vision in dim light. By contrast, in the majority of cockroach photoreceptors the sustained current dominated, which is more common among fast diurnal species. Model simulations indicated that the sustained current is necessary for improved photoreceptor dynamics. Examination of light-induced currents suggested that the functional variability in cockroach photoreceptors is in part derived from variations in the total area of the photosensitive membrane. Recordings of light-induced currents also revealed that the cockroach light-gated channels are only moderately Ca2+-selective and that the polarisation-sensitive photoreceptors of the cricket may utilise phototransduction machinery in some details different from that in regular photoreceptors. Furthermore, the dynamics and information transfer rates of polarisation-sensitive photoreceptors in the cricket were clearly inferior to their regular counterparts, suggesting that they are not necessary for image formation.

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Malezieux, Meryl. "Dynamique intracellulaire des cellules pyramidales de CA3 dans l'hippocampe pendant les états de veille." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0317/document.

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Les états de veille sont composés d’états cérébraux distincts, corrélés avec différents comportements et caractérisés par des oscillations spécifiques observables dans le potentiel de champ local (Local Field Potential, LFP). Bien que les différents états cérébraux et leur signature dans le LFP aient été caractérisés, les mécanismes cellulaires sous-jacents restent à ce jour peu connus. Des changements des propriétés de neurones uniques seraient corrélés avec, et pourraient participer à la génération de ces changements d’états cérébraux. L’activité coordonnée et synchronisée de neurones facilite certains processus cognitifs tels que la mémoire. L’hippocampe joue un rôle essentiel dans les mémoires spatiale et épisodique, et dans l’hippocampe, CA3 est important pour la formation d’associations facilitant l’encodage rapide de la mémoire. De plus, les informations provenant du cortex entorhinal, du gyrus denté, et de CA3 même sont comparées et intégrées dans CA3 avant d’être transmises à CA1. Lors de périodes de repos, le LFP hippocampique présente une activité large et irrégulière (Large Irregular Activity, LIA), ponctuée par des oscillations plus rapides, les sharp-wave ripples, jouant un rôle dans la consolidation de la mémoire. Lors de périodes exploratoires, le LFP hippocampique oscille aux fréquences theta (6-12 Hz) et gamma (30-100 Hz). Les cellules pyramidales (CP) de CA3 jouent un rôle important dans chacun de ces états ; elles sont nécessaires pour les sharp wave lors de périodes de repos, et les oscillations gamma lors de comportements exploratoires. Dans le but d’étudier les modulations intracellulaires des CP de CA3, nous avons réalisé des enregistrements de patch-clamp en configuration cellule entière chez l’animal éveillé. Nous avons associé ces enregistrements avec des mesures du diamètre pupillaire et de la vitesse de locomotion de l’animal, ainsi qu’avec l’enregistrement de l’activité oscillatoire du LFP dans l’hippocampe. Nos résultats montrent que certaines CP de CA3 sont sensibles à la modulation intracellulaire lors de différents rythmes hippocampiques, et ont tendance à diminuer leur potentiel de membrane moyen, leur excitabilité, leur variance et leur décharge de potentiel d’action lors des oscillations theta par rapport aux périodes de LIA. De futures études permettront de déterminer si ces changements sont dus à des changements d’entrées synaptiques et/ou de neuromodulateurs. Ces modulations pourraient jouer un rôle dans l’émergence des rythmes oscillatoires du LFP, et permettre à CA3 de réaliser différentes fonctions mnésiques à différents moments
Wakefulness is comprised of distinct brain states, correlated with different behaviors and characterized by specific oscillatory patterns in the local field potential (LFP). While much work has characterized different brain states and their LFP signatures, the underlying cellular mechanisms are less known. Changes in single cell properties are thought to correlate with and possibly result in these changes in brain state. Synchronized and coordinated activity among distributed neurons supports cognitive processes such as memory. The hippocampus is essential for spatial and episodic memory, and within the hippocampus, area CA3 is important for rapid encoding of one-trial memory. Additionally, CA3 is the site where information from the entorhinal cortex, dentate gyrus, and CA3 itself is compared and integrated before output to CA1. During quiet wakefulness, the hippocampal LFP displays large irregular activity (LIA) punctuated by sharp-wave ripples, which play a role in memory consolidation. During exploratory behaviors, hippocampal LFP oscillates at both theta and gamma frequencies. CA3 pyramidal cells (PCs) play an important role in each of these brain states; they are necessary for both sharp waves during quiet wakefulness and for gamma oscillations during exploratory behavior. We explored the changes that occur in the intracellular dynamics of CA3 PCs during changes in brain state, by using whole-cell patch-clamp recordings from CA3 PCs in awake head-fixed mice. We combined those recordings with measurements of pupil diameter, treadmill running speed and LFP recordings of oscillatory activity. Our findings show that some CA3 PCs are prone to intracellular modulation during brain rhythms, and tend to decrease their average membrane potential, excitability, variance and output firing during theta as compared to LIA. Future studies will demonstrate whether these effects are due to changes in synaptic and/or neuromodulatory inputs. This modulation at the single-cell level in CA3 could play a role in the emergence of oscillations, and underlie the ability of CA3 to perform different memory functions during different brain states

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Books on the topic "Patch-clamp electrophysiology"

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Dallas, Mark, and Damian Bell, eds. Patch Clamp Electrophysiology. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0818-0.

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Patch-clamp methods and protocols. New York: Humana Press, 2014.

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Patch clamping: An introductory guide to patch clamp electrophysiology. New York: J. Wiley, 2003.

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Electrical properties of cells: Patch clamp for biologists. New York: Plenum Press, 1997.

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1931-, Smith T. G., ed. Voltage and patch clamping with microelectrodes. Bethesda, Md: American Physiological Society, 1985.

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1962-, Destexhe Alain, and Bal Thierry, eds. Dynamic-clamp: From principles to applications. New York: Springer, 2009.

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Martina, Marzia, and Stefano Taverna. Patch-Clamp Methods and Protocols. Springer New York, 2016.

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1965-, Molnar Peter, and Hickman James J, eds. Patch-clamp methods and protocols. Totowa, N.J: Humana, 2007.

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Hickman, James J., and Peter Molnar. Patch-Clamp Methods and Protocols. Humana Press, 2010.

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Patch-Clamp Analysis (Neuromethods). Humana Press, 2002.

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Book chapters on the topic "Patch-clamp electrophysiology"

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Hill, Charlotte L., and Gary J. Stephens. "An Introduction to Patch Clamp Recording." In Patch Clamp Electrophysiology, 1–19. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_1.

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Wadsworth, Paul A., Aditya K. Singh, Nghi Nguyen, Clifford Stephan, and Fernanda Laezza. "Bioluminescence Methodology for Ion Channel Studies." In Patch Clamp Electrophysiology, 191–228. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_10.

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Tamagnini, Francesco. "Nucleated, Outside-Out, Somatic, Macropatch Recordings in Native Neurons." In Patch Clamp Electrophysiology, 229–42. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_11.

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Church, Timothy W., and Matthew G. Gold. "Preparation of Rat Organotypic Hippocampal Slice Cultures Using the Membrane-Interface Method." In Patch Clamp Electrophysiology, 243–57. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_12.

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Zhou, Yi, He Li, and Zhongju Xiao. "In Vivo Patch-Clamp Studies." In Patch Clamp Electrophysiology, 259–71. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_13.

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Coddington, Luke T., and Joshua T. Dudman. "In Vivo Optogenetics with Stimulus Calibration." In Patch Clamp Electrophysiology, 273–83. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_14.

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Simonnet, Jean, Louis Richevaux, and Desdemona Fricker. "Single or Double Patch-Clamp Recordings In Ex Vivo Slice Preparation: Functional Connectivity, Synapse Dynamics, and Optogenetics." In Patch Clamp Electrophysiology, 285–309. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_15.

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Boddum, Kim, Peder Skafte-Pedersen, Jean-Francois Rolland, and Sandra Wilson. "Optogenetics and Optical Tools in Automated Patch Clamping." In Patch Clamp Electrophysiology, 311–30. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_16.

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Dolzer, Jan. "Patch Clamp Technology in the Twenty-First Century." In Patch Clamp Electrophysiology, 21–49. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_2.

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Mathie, Alistair, Emma L. Veale, and Robyn G. Holden. "Heterologous Expression of Ion Channels in Mammalian Cell Lines." In Patch Clamp Electrophysiology, 51–65. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0818-0_3.

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Conference papers on the topic "Patch-clamp electrophysiology"

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Yang, Runhuai, King W. C. Lai, Ning Xi, and Jie Yang. "Development of automated patch clamp system for electrophysiology." In 2013 IEEE International Conference on Robotics and Biomimetics (ROBIO). IEEE, 2013. http://dx.doi.org/10.1109/robio.2013.6739793.

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Saponara, Sergio, Fabio Fusi, Simona Saponara, Massimo Macucci, and Voicu Groza. "Failure mode and effect analysis of patch-clamp laboratory instrumentation for electrophysiology measurements." In 2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA). IEEE, 2017. http://dx.doi.org/10.1109/memea.2017.7985853.

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Wilson, Jim R., and Neil A. Duncan. "Modelling the Ion Channel Behaviour of Articular Chondrocytes." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32661.

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All cells have a membrane potential; this voltage difference arises from the different intracellular and extracellular ion concentrations. In excitable tissue the cell membranes contain ion channels which control the movement of ions and hence control the cell’s membrane potential. Extensive measurements of the electrophysiology of excitable cells has allowed considerable understanding of the ion channels. The Hodgkin-Huxley model [1] was developed from measurements on a squid nerve axon, and it quantifies the changes in membrane conductance due to the opening and closing of specific ion channels. This model has been very successful in describing the electrical behaviour of neurons. Ion channels also exist in non-excitable tissue cells. Patch clamp experiments have demonstrated that ion channels in chondrocytes influence cell’s membrane potential [2]; controls the influx of Ca2+ [3] and may regulate cell proliferation [2]. The objective of this research was to develop a model of ion channel behaviour for connective tissue cells based on the Hodgkin-Huxley model, and to apply this model to reported patch clamp measurements of articular chondrocytes.

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