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Journal articles on the topic 'Patek Philippe'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Butov, A. V. "COMPETITIVE ADVANTAGES AND MANAGEMENT PRINCIPLES AT THE PATEK PHILIPPE COMPANY." Vestnik of the Plekhanov Russian University of Economics 1, no. 1 (2020): 179–85. http://dx.doi.org/10.21686/2413-2829-2020-1-179-185.

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2

Butov, Aleksandr V. "EVOLUTION OF THE MODEL RANGE AND CORPORATE STRATEGIES IN THE WATCH INDUSTRY." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 3/2, no. 123 (2022): 70–78. http://dx.doi.org/10.36871/ek.up.p.r.2022.03.02.008.

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The purpose of the article is to study the evolution of the model range in the watch industry and to study the theory and practice of using industry corporate strategies developed by the head of the Montblanc watch division L. Lecamp and professor of the SKEMA Business School J. Hoffman. These four most popular industry strategies (“Back to Basics”, “Codebreakers”, “Eagle in the Aquarium” and “Other rules of the game”), as the analysis showed, are used by most watch brands to increase the efficiency of economic activity. This article examines the development strategies and competitive advantag

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3

Kochkina, Nataliia, and Borys Kharchenko. "CONSUMER MOTIVATION IN THE LUXURY WATCH MARKETS OF UKRAINE AND ITALY: PRE-PANDEMIC/WAR TRENDS AND PREDICTIONS." Bulletin of Taras Shevchenko National University of Kyiv. Economics, no. 222 (2023): 69–75. http://dx.doi.org/10.17721/1728-2667.2023/222-1/9.

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This article examines consumer motivation within the luxury watch markets of Ukraine and Italy before the onset of the COVID-19 pandemic and the war in Ukraine, as well as their future prospects following the conflict's conclusion. The expert survey indicates that both countries share similar motivations and purchasing behavior, with social status, fashion, and personal preferences serving as the primary drivers for luxury consumption. Ukrainian consumers exhibit more overtly demonstrative behavior driven by status, wealth, and social group alignment. Italians prioritize social motives, presti

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Czapla, Beniamin. "Kontakty Antoniego Patka ze zmartwychwstańcami." Biografistyka Pedagogiczna 8, no. 3 (2023): 53–62. http://dx.doi.org/10.36578/bp.2023.08.69.

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Antoni Patek przyszedł na świat w 1812 r. na Lubelszczyźnie. Jako żołnierz wziął udział w powstaniu listopadowym. Po jego upadku udał się na emigrację. W 1835 r. osiadł w Szwajcarii Versoix koło Genewy. Tam też poznał innego polistopadowego emigranta – zegarmistrza Franciszka Czapka. W 1839 r. Patek i Czapek zawiązali spółkę produkującą zegarki Patek, Czapek et Cie. Firma skupiała się głównie na zaopatrywaniu polskiej klienteli. Dlatego też ich zegarki były zdobione wizerunkami polskich królów, książąt, portretami bohaterów narodowych i motywami religijnymi. W 1845 r. Patek zerwał współpracę z

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5

Lee, Anna Y., David M. Berman, Robert Lesurf, et al. "Abstract B046: Multimodal biomarkers that predict the presence of Gleason pattern 4: Potential impact for active surveillance." Cancer Research 83, no. 11_Supplement (2023): B046. http://dx.doi.org/10.1158/1538-7445.prca2023-b046.

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Abstract Purpose: Latent Grade Group (GG) ≥2 prostate cancer can impact the performance of active surveillance (AS) protocols. To date, molecular biomarkers for AS have relied solely on RNA or protein. We trained and independently validated multimodal (mRNA abundance, DNA methylation, and DNA copy number) biomarkers that more accurately separate GG1 from GG≥2 cancers. Materials and Methods: Low- and intermediate-risk prostate cancer patients were assigned to training (n=333) and validation (n=202) cohorts. We profiled the abundance of 342 mRNAs, 100 DNA copy number aberration (CNA) loci and 14

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Piumatti, Eleonora, Alexia Hervieu, Philippe Riou, et al. "Abstract 6011: Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo." Cancer Research 84, no. 6_Supplement (2024): 6011. http://dx.doi.org/10.1158/1538-7445.am2024-6011.

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Abstract Tumors carrying defects in DNA mismatch repair (MMR-d) display high tumor mutational burden (TMB) and increased tumor neoantigen levels. MMR-d leads to accumulation of single nucleotide variants (SNVs) and insertions or deletions (indels) amongst repetitive DNA sequences generating microsatellite instability (MSI). Cancers that harbor &gt;40% microsatellite variations are described as MSI-high (MSI-H). These tumors display unique clinical features including better prognosis, increased immune infiltration and remarkable response to immune checkpoint blockade (ICB) therapy. Colorect

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Dubash, Taronish D., Aditya Bardia, Brian Chirn, et al. "Abstract CT073: Efficacy of novel oral SERD elacestrant in fulvestrant-refractory hormone receptor-positive (HR+) breast cancer: a translational investigation." Cancer Research 83, no. 8_Supplement (2023): CT073. http://dx.doi.org/10.1158/1538-7445.am2023-ct073.

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Abstract Purpose: Metastatic HR+ breast cancer initially responds to serial courses of endocrine therapy but ultimately becomes refractory Elacestrant, a new generation oral selective estrogen receptor degrader (SERD) and antagonist, has demonstrated efficacy in a subset of women with advanced HR+ breast cancer (Bidard FC, et al J Clin Oncol 2022;40:3246-3256), but there are few patient-derived models to characterize its effect in advanced cancers with diverse treatment histories and acquired mutations In this translational study, we tested the efficacy of elacestrant on ex vivo circulating tu

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Srivastava, Gitika, Sara Nizzero, Mark Wasley, et al. "Abstract 1178: Tissue nanomechanics as a novel, clinically translatable predictive early biomarker of response in combination immunotherapy." Cancer Research 84, no. 6_Supplement (2024): 1178. http://dx.doi.org/10.1158/1538-7445.am2024-1178.

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Abstract Background: Recently, the successful integration of immunotherapy with other treatment modalities has demonstrated its efficacy in enhancing immune activation and suppressing tumors in solid cancers. The most promising of such efforts include the use of low dose radiation (LD-XRT) to prime the tumor microenvironment and enhance the T cell infiltration and activation [Barsoumian HB, et al., 2020; Patel RR, et al., 2021; He K, et al., 2023]. With these advancements, there is an urgent need to develop clinical biomarkers to predict response and optimize treatment decisions. Recent eviden

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9

Samson, Adel, Cristina Smolenschi, Philippe Cassier, et al. "Abstract CT190: Oncolytic virus TG6002 safety and activity after intrahepatic artery administration in patients with liver-dominant metastatic colorectal cancer." Cancer Research 83, no. 8_Supplement (2023): CT190. http://dx.doi.org/10.1158/1538-7445.am2023-ct190.

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Abstract The TG6002.03 trial is a dose-escalation phase 1 clinical trial of TG6002 infusion via the hepatic artery in patients with liver-dominant colorectal cancer metastases. TG6002 is an engineered Copenhagen strain oncolytic Vaccinia virus, deleted of thymidine kinase and ribonucleotide reductase to enhance tumor selective viral replication and expressing FCU1, an enzyme converting the non-cytotoxic prodrug 5-fluorocytosine (5-FC) into the chemotherapeutic compound 5-fluorouracil (5-FU). In this trial, patients with advanced unresectable liver-dominant metastatic colorectal cancer who had

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10

Blagg, Julian, Philippe Riou, Alexia Hervieu, et al. "Abstract C086: NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): C086. http://dx.doi.org/10.1158/1535-7163.targ-23-c086.

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Abstract Two complementary mechanisms safeguard genome fidelity during DNA replication: DNA polymerase proofreading and DNA mismatch repair (MMR). DNA polymerase proofreading or MMR deficiencies can occur independently or, more rarely, simultaneously; loss of function of either or both pathways leads to the accumulation of DNA mutations. Lynch Syndrome is caused by mono-allelic germline mutations in MMR genes MLH1, MSH2, MSH6 or PMS2. Gene expression from the wild-type allele elicits sufficient MMR activity until a second hit somatic mutation inactivates the wild-type allele leading to MMR def

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11

Ramesh, Radha, Kai Ding, Xin Tong, et al. "Abstract LB397: Biomarker-guided dose selection in the iintune-1 study of dazostinag,a STING agonist, alone and in combination with pembrolizumab for patients with metastatic solid tumors." Cancer Research 85, no. 8_Supplement_2 (2025): LB397. https://doi.org/10.1158/1538-7445.am2025-lb397.

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Abstract Background: The dazostinag (TAK-676) STING agonist activates innate and adaptive immune responses, including dose-dependent induction of cytokine responses and activation/proliferation of immune cells in preclinical tumor models. We present biomarker and pharmacokinetic (PK) data from the dose escalation portion of iintune-1 (NCT04420884), a phase 1 study of dazostinag as a single agent (SA) or in combination with pembrolizumab (pembro) in advanced or metastatic solid tumors. Biomarker data in conjunction with PK, safety, and efficacy was evaluated to inform dazostinag dose selection

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12

Guelen, Melisa S., Tobias R. Bodenmann, Mason C. Cleveland, et al. "Abstract B023: Deep learning-based prediction of immune checkpoint inhibitor efficacy in brain metastases using brain MRI." Clinical Cancer Research 31, no. 13_Supplement (2025): B023. https://doi.org/10.1158/1557-3265.aimachine-b023.

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Abstract Introduction: Brain metastases (BM) are an emerging challenge in modern oncology due to increasing incidence and limited treatments. Recent work by our group and others has illustrated that immune checkpoint inhibitors (ICI) are a promising therapy for treatment-refractory BM of diverse histologies. Yet, likelihood of response to ICI varies highly between patients, and the therapy often causes severe adverse effects. To build upon our findings and integrate ICI into precision medicine strategies for BM, scalable tools that quantify likelihood of response are needed. Methods: We curate

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13

Graham, Charlotte, Deborah Yallop, Agnieszka Jozwik, et al. "Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a First-in-Human Trial (CALM) in Adult Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia." Blood 130, Suppl_1 (2017): 887. http://dx.doi.org/10.1182/blood.v130.suppl_1.887.887.

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Abstract Background UCART19 is a genetically modified T-cell product manufactured from non-HLA matched healthy donor cells. Lentiviral-transduced CAR T-cells express (1) an anti-CD19 CAR (anti-CD19 scFv- 41BB- CD3ζ) and (2) an RQR8 "safety switch" that is intended to allow targeted elimination of RQR8+ cells by rituximab. UCART19 has been additionally modified to disrupt the T-cell receptor alpha constant (TRAC) and CD52 genes. The preliminary results of this "off-the-shelf" allogeneic CAR T-cell therapy in a phase I, dose-escalation trial of UCART19 in CD19+ R/R B-ALL adult patients (pts) are

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14

-, Pia Kothari, Abdul Rasheed -, and Jharna Kalra -. "An Empirical Analysis of the Performance of Luxury Watch Portfolios among High-Net-Worth Individuals in India During the COVID-19 Pandemic." International Journal For Multidisciplinary Research 6, no. 5 (2024). http://dx.doi.org/10.36948/ijfmr.2024.v06i05.29277.

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This study empirically evaluates luxury watches owned by high-net-worth individuals (HNIs) in India as unconventional alternative assets providing diversifying benefits. During the COVID-19 pandemic, the major stock exchanges in India, NSE and BSE, faced negative returns and high volatility, igniting numerous conservative investors to divest from traditional investments and retain alternative assets, such as luxury watches, due to their low correlation to financial markets. Owing to supply chain disruptions and demand forces, the overall secondary watch market prices surged throughout this per

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15

Dave, Meet, and Palak Gupta. "Elegance in Promotion: A Comparative Study of Advertising Techniques for Luxury Watches, Jewellery and Fashion." International Journal of Innovative Science and Research Technology, April 25, 2025, 1226–35. https://doi.org/10.38124/ijisrt/25apr1343.

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In the luxury goods market, advertising is a critical factor in shaping consumer perceptions and sustaining brand prestige. This paper examines the sophisticated advertising strategies employed by luxury brands in the watch, jewelry, and fashion sectors. These market segments not only epitomize exclusivity but also depend on refined promotional techniques to maintain their desirability. Unlike conventional advertising, luxury advertising emphasizes exclusivity and aspiration, underscoring the superior quality, craftsmanship, and prestige associated with luxury brands. Luxury watches advertisem

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16

Holzapfel, Lena, and Carolin Klar. "Interview mit Manuel Philipp – Paten der Nacht." Anliegen Natur, November 27, 2023, 123. https://doi.org/10.63653/mmff3164.

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In einer klaren Nacht den Sternenhimmel zu beobachten, ist für viele Menschen eine schöne Vorstellung. Das ist vielerorts gar nicht mehr möglich, denn meist ist es zu hell. Und mehr noch: zu viele und zu helle Lichtquellen beeinträchtigen Tiere, Pflanzen und auch uns Menschen.

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17

"Acknowledgment of Abstract Graders." Circulation 126, suppl_21 (2012). https://doi.org/10.1161/circ.126.suppl_21.a401.

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Abbara, Suhny Georgiou, Demetrios naka, yoshifumi Abbott, Brian Gerszten, Robert Nakagawa, Yoshihisa Abbott, Geoffrey . Gewillig, Marc Nakamura, Kazufumi Abe, Jun-ichi Ghali, Jalal K. Nakamura, Yasuyuki Abella, Benjamin S. Ghanayem, Nancy Nakanishi, Toshio Abraham, Theodore Ghanayem, Nancy Nakatani, Toshio Abraham, William T. Ghosh, Shobha Narayan, Sanjiv M. Achenbach, Stephan Giachelli, Cecilia M. Natale, Andrea Acker, Michael A. Gidding, Samuel S. Natarajan, Rama Ackerman, Michael J. Gidding, Samuel S. Nattel, Stanley Adams, M. Jacob Gilchrist, Ian Nazarian, Saman Adams, Ted Giles, Thomas D.

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18

"Acknowledgment of Abstract Reviewers." Circulation 128, suppl_22 (2013). https://doi.org/10.1161/circ.128.suppl_22.a401.

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Abbara, Suhny Abbott, J Dawn Abe, Jun-ichi Abraham, William T. Achenbach, Stephan Ackerman, Michael J. Adabag, Selcuk Adams, Ted Adatya, Sirtaz Ades, Philip A. Ahmed, Bina Aikawa, Elena Ailawadi, Gorav Aizawa, Yoshifusa Aizer, Anthony Akagi, Teiji Akar, Fadi Akhter, Shahab Al Khatib, Sana Al-Ahmad, Amin Al-Mallah, Mouaz Alberts, Mark J. Alexander, John H.. Alexander, Mark Ali, Mo Allen, Larry A. Allen, Norrina B. Allison, Matthew A. Ambrosio, Giuseppe Amsterdam, Ezra Anand, Inder S. Andelfinger, Gregor Anderson, Mark E. Andresen, Brad Antoniucci, David Anversa, Piero Anyanwu, Ani Aon, Miguel A

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19

Silao, Catherine Lynn T. "Perspectives on the Use of Telegenetics Services in the Philippines." Acta Medica Philippina 57, no. 8 (2023). http://dx.doi.org/10.47895/amp.v57i8.8572.

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The Philippines is a densely populated nation faced with multiple challenges in the healthcare field given its geographic,cultural, and socioeconomic barriers. Due to the geographic limitations of medical services in the country, many patientsmust travel a great distance to referral centers. This was further exacerbated by the Coronavirus disease 2019 (COVID-19)pandemic, which spread across the world and upended lives. This pandemic triggered a public health crisis that impactedhealthcare systems, healthcare workers, and communities worldwide. It compounded current difficulties with the provis

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20

"Acknowledgment of Abstract Graders." Circulation 124, suppl_21 (2011). https://doi.org/10.1161/circ.124.suppl_21.a401.

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We would like to thank the following abstract graders for their invaluable time and effort in reviewing abstracts for Scientific Sessions 2011. Brian Abbott Friederike K. Keating Geoffrey Abbott John Kern Evan Abel Karl Kern Benjamin S. Abella Morton Kern Theodore Abraham Amit Khera William T. Abraham Raymond J. Kim Stephan Achenbach Sue Kimm Michael A. Acker Carey D. Kimmelstiel Michael J. Ackerman Jacobo Kirsch David H. Adams Joel Kirsh M. Jacob Adams Lorrie Kirshenbaum Ted Adams Raj Kishore Philip A. Ades Masafumi Kitakaze Gail K. Adler Andre Kleber Sunil K. Agarwal Neil S. Kleiman Frank Ag

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21

Pereira, Maria Devany, Nayra do Socorro Caldas Carvalho de Alme Teixeira, Iara Katrynne Fonsêca Oliveira, Carlos Henrique Ribeiro Lima, and Adriana de Azevedo Paiva. "Esquema terapêutico e consumo alimentar em pessoas vivendo com HIV/Aids." ARCHIVES OF HEALTH INVESTIGATION 8, no. 7 (2019). http://dx.doi.org/10.21270/archi.v8i7.4625.

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Introdução: O HIV é o vírus responsável por destruir os linfócitos T CD4+, sua evolução ocorre a partir de distúrbios que causam infecções oportunistas, alterações nutricionais e até a morte. Uma infecção sexualmente transmissível que atualmente ainda acomete milhares de pessoas no Brasil e no mundo, independente de sexo, raça e condição econômica. A terapia antirretroviral prolonga a vida de Pessoas Vivendo com HIV/Aids diminuindo também a chance de transmissão. Atenção nutricional a esse público é essencial, devido alterações fisiológicas que interferem desde a mastigação até a absorção, ass

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22

"International Stroke Conference 2013 Abstract Graders." Stroke 44, suppl_1 (2013). http://dx.doi.org/10.1161/str.44.suppl_1.aisc2013.

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Alex Abou-Chebl, MD Michael Abraham, MD Joseph E. Acker, III, EMT-P, MPH Robert Adams, MD, MS, FAHA Eric Adelman, MD Opeolu Adeoye, MD DeAnna L. Adkins, PhD Maria Aguilar, MD Absar Ahmed, MD Naveed Akhtar, MD Rufus Akinyemi, MBBS, MSc, MWACP, FMCP(Nig) Karen C. Albright, DO, MPH Felipe Albuquerque, MD Andrei V. Alexandrov, MD Abdulnasser Alhajeri, MD Latisha Ali, MD Nabil J. Alkayed, MD, PhD, FAHA Amer Alshekhlee, MD, MSc Irfan Altafullah, MD Arun Paul Amar, MD Pierre Amarenco, MD, FAHA, FAAN Sepideh Amin-Hanjani, MD, FAANS, FACS, FAHA Catherine Amlie-Lefond, MD Aaron M. Anderson, MD David C.

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