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Dissertations / Theses on the topic 'Patham'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Nagubadi, RadhaKrishna. "K Shortest Path Implementation." Thesis, Linköpings universitet, Databas och informationsteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-95451.

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The problem of computing K shortest loopless paths, or ranking of the K shortest loopless paths between a pair of given vertices in a network is a well-studied generalization of shortest path problem. The K shortest paths problem determines not only one shortest path but the K best shortest paths from s to t in an increasing order of weight of the paths. Yen’s algorithm is known to be the efficient and widely used algorithm for determining K shortest loopless paths. Here, we introduce a new algorithm by modifying the Yen’s algorithm in the following way: instead of removing the vertices and th

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2

Dash, Suvendu Kumar. "Context-based metrics for evaluating changes to web pages." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/79.

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The web provides a lot of fluid information but this information changes, moves, and even disappears over time. Bookmark lists, portals, and paths are collections where the building blocks are web pages, which are susceptible to these changes. A lot of research, both in industry and in academia, focuses on organizing this vast amount of data. In this thesis, I present context-based algorithms for measuring changes to a document. The methods proposed use other documents in a collection as the context for evaluating changes in the web pages. These metrics will be used in maintaining paths as th

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3

Regan, Lucy. "Metabolic pathway engineering of the toluene degradation pathway." Thesis, University College London (University of London), 1995. http://discovery.ucl.ac.uk/1317891/.

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This thesis addresses the problem of how to examine a metabolic pathway and identify what are the key elements, specifically with respect to rate-limitation. The aim is to be able to analyze a pathway, identify the bottlenecks and implement genetic modifications to remove these bottlenecks. This is done by defining the system of interest and developing a predictive model using kinetic data. The model predictions can then be verified using fermentation data and genetic techniques to make the appropriate changes for improved performance. The test system chosen for this study was the TOL meta-cle

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4

Blythe, Joe. "Doing referring in Murriny Patha conversation." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/5388.

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Successful communication hinges on keeping track of who and what we are talking about. For this reason, person reference sits at the heart of the social sciences. Referring to persons is an interactional process where information is transferred from current speakers to the recipients of their talk. This dissertation concerns itself with the work that is achieved through this transfer of information. The interactional approach adopted is one that combines the “micro” of conversation analysis with the “macro” of genealogically grounded anthropological linguistics. Murriny Patha, a non-Pama-Nyung

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5

Blythe, Joe. "Doing referring in Murriny Patha conversation." University of Sydney, 2009. http://hdl.handle.net/2123/5388.

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Doctor of Philosophy<br>Successful communication hinges on keeping track of who and what we are talking about. For this reason, person reference sits at the heart of the social sciences. Referring to persons is an interactional process where information is transferred from current speakers to the recipients of their talk. This dissertation concerns itself with the work that is achieved through this transfer of information. The interactional approach adopted is one that combines the “micro” of conversation analysis with the “macro” of genealogically grounded anthropological linguistics. Murriny

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6

Muhandiramge, Ranga. "Maritime manoeuvring optimization : path planning in minefield threat environments." University of Western Australia. School of Mathematics and Statistics, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0015.

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The aim of the research project that is the subject of this thesis is to apply mathematical techniques, especially those in the area of operations research, to the problem of maritime minefield transit. We develop several minefield models applicable to different aspects of the minefield problem. These include optimal mine clearance, shortest time traversal and time constrained traversal. We hope the suite of models and tools developed will help make mine field clearance and traversal both safer and more efficient and that exposition of the models will bring a clearer understanding of the mine

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7

Fenwick, Joel. "Visibility-Preserving Movement for Teams - Algorithms for Walking Minimal Paths." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/365582.

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There is a large body of research into finding short (if not shortest) paths in a wide variety of environments including graphs, polygons and the two dimensional plane with polygonal obstacles, to name just a few. Much of this research has been focussed on moving a single (possibly complex) entity through the environment under a variety of cost metrics. In recent years, relatively inexpensive robots have become more accessible, ranging from basic kits to complete units such as the Sony AiboTM. At the same time, virtual environments have been increasing in sophistication. For the past decade or

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8

Isik, Zerrin. "Network Structure Based Pathway Enrichment System To Analyze Pathway Activities." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612951/index.pdf.

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Current approaches integrating large scale data and information from a variety of sources to reveal molecular basis of cellular events do not adequately benefit from pathway information. Here, we portray a network structure based pathway enrichment system that fuses and exploits model and data: signalling pathways are taken as the biological models while microarray and ChIP-seq data are the sample input data sources among many other alternatives. Our model- and data-driven hybrid system allows to quantitatively assessing the biological activity of a cyclic pathway and simultaneous enrichment o

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9

Svensson, Filip. "Tolkien's Natural Pathos." Thesis, Linnéuniversitetet, Institutionen för språk och litteratur, SOL, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-6585.

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10

Tozer, Mark. "The leadership pathway:." Thesis, Bangor University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505942.

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11

Roche, Michael William. "The Beaten Pathos." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/53997.

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The Beaten Pathos is a manuscript of poems written by a shelter dog--a shelter dog whose distrust of both his reader-dogs and himself amplifies his need to communicate. More often than not, the result is a poem borne of an imagination both ostentatiously loud and cutting at an oblique angle, like a miter saw. Additionally, a handful of poems are muted and cool (like Miles Davis' trumpet), and, consequently, more direct in their expression of the poet's emotional vulnerability. Whether the poems in this manuscript are of the miter-saw or trumpet variety, their speakers--although frequently not

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12

HASEGAWA, Hiroshi, and Ken-ichi SATO. "Prospects and Challenges of Multi-Layer Optical Networks." Institute of Electronics, Information and Communication Engineers, 2007. http://hdl.handle.net/2237/14981.

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13

Allen, Emily. "Combinatorial Interpretations Of Generalizations Of Catalan Numbers And Ballot Numbers." Research Showcase @ CMU, 2014. http://repository.cmu.edu/dissertations/366.

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The super Catalan numbers T(m,n) = (2m)!(2n)!=2m!n!(m+n)! are integers which generalize the Catalan numbers. Since 1874, when Eugene Catalan discovered these numbers, many mathematicians have tried to find their combinatorial interpretation. This dissertation is dedicated to this open problem. In Chapter 1 we review known results on T (m,n) and their q-analog polynomials. In Chapter 2 we give a weighted interpretation for T(m,n) in terms of 2-Motzkin paths of length m+n2 and a reformulation of this interpretation in terms of Dyck paths. We then convert our weighted interpretation into a conven

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14

Bodet, Sophie. "Le film colorié : techniques et esthétiques." Paris 8, 2000. http://www.theses.fr/2000PA081671.

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Le coloriage des films etudie dans ce travail se situe essentiellement durant la periode anterieure aux annees trente. Une premiere partie decrit la mise en oeuvre du coloriage entre 1892 et 1929, la seconde etudie sur cette meme periode le corpus concerne. L'environnement de la pratique est aborde en partant des principales influences dont celle de la lanterne magique. Les aspects techniques et esthetiques du travail d'emile reynaud sont l'objet d'un chapitre specifique auquel succede l'inventaire des multiples ateliers ou s'effectuait le coloriage des films. Ce fonctionnement artisanal va et

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15

Reilly, Ryan Egan. "Storytelling pathway to literacy /." Online pdf file accessible through the World Wide Web, 2007. http://archives.evergreen.edu/masterstheses/Accession89-10MIT/Reilly_R%20MITthesis%202007.pdf.

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16

Thorstensen, Sonia Christina. "Incestualidade: um Pathos familiar." Pontifícia Universidade Católica de São Paulo, 2011. https://tede2.pucsp.br/handle/handle/15076.

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Made available in DSpace on 2016-04-28T20:37:56Z (GMT). No. of bitstreams: 1 Sonia Christina Thorstensen.pdf: 363239 bytes, checksum: 3145317df44310cd98a2f490334a42d2 (MD5) Previous issue date: 2011-10-21<br>This dissertation proposes a discussion on the phenomenon of incestuality, conceived as a primal and regressive dimension of sexuality and sustained by an illusion of completeness. Incestuality permeates the entire family and, in its vitai and necessary aspects, is responsible for the psychic constitution of the younger generations. But it can also imprison the family's members and becom

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17

Boylan, Arianne J. "CCM2 molecular signaling pathway." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08062007-135532/.

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18

Lindgren, Kim. "Under which conditions is the C4metabolic pathway favored? : When does the C4 metabolic pathway become less costlythan the C3 metabolic pathway?" Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53180.

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C4 photosynthesis is an advanced complement to the more ancestral and more commonpathway refereed to as C3. C4 metabolism has evolved in several taxa, and it is theorized thatit worked as an adaptation to the low CO 2 levels characteristic of late geological time. Theadaptation also carries with it some resistance to the negative effects brought on by hightemperatures and drought. C4 metabolism is, however, not free, meaning that underconditions of lower temperature and higher CO2-levels, C3 photosynthesis is still moreviable. This makes it interesting to study how C4-species might shift their

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19

Pathak, Indu Prabha [Verfasser]. "Thomas Hardy’s Philosophical Influences in his Poetry / Indu Prabha Pathak." München : GRIN Verlag, 2018. http://d-nb.info/116777826X/34.

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20

Mead, Geoffrey. "'Scattered squalor' and 'downland homes' : interwar housing at Patcham, Brighton." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/40308/.

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The Brighton suburb of Patcham is an area which was transforming rapidly into a suburban housing district in the interwar period. An urban fringe area, where the distinction between the various housing areas is largely explained by the differential ownership and sale of the former agricultural land, and the subsequent development as suburban housing under different developers. The factors bringing about the urban expansion, particularly in relation to Brighton and its growing economy are discussed, as is the declining agricultural economy. A variety of suburban housing types emerged, ranging f

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21

Bernstein, Jeffrey Robert. "Horizontal pathway transfer to Escherichia coli from Rhodopseudomonas palustris transcription, translation, pathway extension /." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1495958891&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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22

Rui, Hongliang. "Regulation of MAPK/JNK signaling pathway and TGF-beta signaling pathway by axin /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20RUI.

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Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2004.<br>CD-ROM contains electronic versons of the thesis in pdf and word format. Includes bibliographical references (leaves 129-151). Also available in electronic version. Access restricted to campus users.

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23

Suzuki, Takeru. "Strong Resultatives as a Bounded PathPP Construction: PathPP Structure and Parametrized Path Head Movement." University of Arizona Linguistics Circle, 2012. http://hdl.handle.net/10150/253426.

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This paper examines the Strong Resultative construction by comparing it with several path related constructions. It advances an analysis in which they all have a bounded path P. Its covert variant underlies some of the path related constructions and the Strong Resultative construction. We will see that the semantic property and the properties related with the phonetic emptiness of a bounded path P derive various characteristics of both of the constructions. I discuss implications and questions about the present analysis, one of which concerns the dual source of apparently the same meaning.

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24

Han, Sung-Jun. "Études sur les voies de signalisation de la réponse immunitaire dans Drosophila melanogaster et Anopheles gambiae." Paris 6, 2002. http://www.theses.fr/2002PA066174.

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25

Peters, Björn. "Modeling the MHC-I pathway." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970139284.

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26

Schumacher, Björn. "The C. elegans p53 pathway." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-19806.

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27

McPhee, Fiona. "Studies of the phosphoinositide pathway." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276816.

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28

Wright, Alan. "Bayesian pathway analysis in epigenetics." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1286.

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A typical gene expression data set consists of measurements of a large number of gene expressions, on a relatively small number of subjects, classified according to two or more outcomes, for example cancer or non-cancer. The identification of associations between gene expressions and outcome is a huge multiple testing problem. Early approaches to this problem involved the application of thousands of univariate tests with corrections for multiplicity. Over the past decade, numerous studies have demonstrated that analyzing gene expression data structured into predefined gene sets can produce ben

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29

Ortica, Sara. "Notch pathway in liver progenitors." Paris 7, 2012. http://www.theses.fr/2012PA077175.

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La voie de signalisation Notch intervient dans la communication intercellulaire. Chez les mammifères, quatre récepteurs Notch (Notch 1-4) sont exprimés. Ils sont présents sous forme hétérodimérique à la surface cellulaire. Après l'interaction avec un ligand, Notch est activé par une cascade de clivages. La forme activée du récepteur (Nie, pour "Notch intracellulaire") est alors transportée dans le noyau, où elle active la transcription des gènes cibles. Pour mieux comprendre l'influence de Notch sur les progéniteurs hépatiques nous avons utilisé un système in vitro basé sur des cellules bipote

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30

Suryana, Eurwin. "Copper and the nigrostriatal pathway." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/22423.

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In Parkinson’s disease (PD), dopaminergic cells in the degenerating substantia nigra (SN) exhibit low copper ion (Cu) levels. Initial clinical testing of the Cu compound Cu2+diacetylbis( 4-methyl-thiosemicarbazonato) (CuATSM) for PD reports some clinical benefits but its mechanism of action is not fully understood. This may be investigated in PD animal models, but none currently model Cu deficiency. Thus, this thesis combined the classic 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxin with a copper transport 1 knockdown (Ctr1+/–) mouse to produce a model exhibiting

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31

Moran, Renee Rice, Karen Keith, and Huili Hong. "One University’s Pathway to Implementation." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/977.

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This chapter focuses on the process of implementing problem based assessment at the college/university level in teacher education. Past research points to an overemphasis on factual information, lecture, and paper and pencil tests in higher education. Performance based assessment is discussed as an alternative and a measure that calls for students to demonstrate more active participation, critical thinking, and work that aligns more closely to what they will actually be engaged in in the field of education after graduation. Particularly, a case study of one university's path in the implementat

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32

Peters, Björn. "Modeling the MHC-I pathway." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2003. http://dx.doi.org/10.18452/14987.

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Das Immunsystems muss gesunde Zellen von infizierten und Krebszellen unterscheiden können, um letztere selektiv zu bekämpfen. Dies ist die Aufgabe der CTL-Zellen, die dazu auf der Zelloberfläche präsentierte Peptide die aus intrazellulären Proteinen der jeweiligen Zelle stammen untersuchen. Diese präsentierten Peptide (Epitope) werden durch den MHC-I Antigenpräsentationsweg hergestellt. Das Ziel dieser Arbeit ist es Methoden zu entwickeln die Epitope aus der großen Zahl prinzipiell in Proteinen enthaltener Peptide heraussuchen können. Dazu wird die Selektivität dreier wichtiger Komponenten des

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33

D'Alessandro, Alba. "p53 regulates Mevalonate Metabolic pathway." Doctoral thesis, Universita degli studi di Salerno, 2014. http://hdl.handle.net/10556/1461.

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2012-2013<br>The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced expression of mevalonate pathway enzymes, including 3’-Hydroxy-3’-Methylglutaryl - CoenzymeA Reductase, Mevalonate Kinase, Farnesyl Diphosphate Synthase, Farnesyl Diphosphate Farnesyl Transferase 1. Three different cell lines have been considered, U343 MG (U343) and U251 MG (U251) glioma cells, both classified as IV grade glioblastoma cell lines, with two differen

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34

Herdman, Michelle L. "Thimerosal-induced neurotoxicity apoptosis occurs through a mitochondrial-mediated pathway via the JNK signaling pathway /." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=685.

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35

Moleirinho, Susana. "Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/3662.

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The mechanism of body and organ size control is an unsolved puzzle. Initially characterized in Drosophila melanogaster, the Salvador/Warts/Hippo (Hippo) signalling pathway, highly conserved throughout evolution, defines a novel signalling cascade regulating cell contact inhibition, organ size control, cell growth, proliferation, apoptosis, and cancer development in mammals. The upstream regulation of this pathway has been less well defined than the core kinase cassette. Previously Willin/FRMD6 has been proposed as the human orthologue of Expanded and, to date, little is known about the functio

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36

Din, Shahida. "Constitutive activation of the ATM DNA damage response pathway in cancer represents a deregulated pathway." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18016.

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Constitutive activation of the ATM dependent DNA damage response and repair pathways have been reported in pre-malignant and malignant human tissues and may undermine the efficacy of genotoxic cancer therapies. Therefore, ATM inhibitors may overcome resistance to current cytotoxics and potentiate the effects of radiotherapy. A colorectal cancer model was investigated to develop a framework for the rational use of ATM inhibitors. HCT116 p21-/- cells display constitutive activation of the ATM DNA damage response but display a defect in the ionising radiation induced S-phase checkpoint, termed ra

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FABRIZIO, FEDERICO PIO. "Keap1/Nrf2 Pathway Profiling: Uncovers Molecular Intersection With Notch Pathway In Small Cell Lung Cancer." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382259.

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Il tumore polmonare a piccole cellule (SCLC), detto anche microcitoma, costituisce circa il 20% dei tumori polmonari e rappresenta una delle istologie più aggressive nell’uomo in quanto è caratterizzato da una iniziale responsività alla chemio e alla radioterapia, a seguito della quale sviluppa velocemente resistenza ai trattamenti. Negli ultimi anni l’efficacia nel colpire i meccanismi molecolari che sono alla base dell’insorgenza e dello sviluppo dei tumori nell’uomo, ha spinto i ricercatori ad identificare e caratterizzare sempre nuove proteine che potessero fungere da bersaglio molecolare

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38

Tian, Lin. "Improved Shortest Path Algorithms by Dynamic Graph Decomposition." Thesis, University of Canterbury. Computer Science and Software Engineering, 2006. http://hdl.handle.net/10092/1196.

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In this thesis, we introduce three new approaches for solving the single source shortest path (SSSP) problem in nearly acyclic directed graphs, and algorithms based on these approaches. In the first approach, we extend a technique of strongly connected components (sc-components) decomposition by Takaoka [23], and the generalized decomposition approach is called a higher-order decomposition. According to Takaoka's definition of acyclicity, the degree of cyclicity of a graph G, cyc(G), is defined by the maximum cardinality of the strongly connected components of G. Based on the higher-order deco

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Senavattanagul, Thanahathai. "Vulnerability and Resilience of the Bang Luang Community to Flooding from the Chao Phraya River." The University of Waikato, 2008. http://hdl.handle.net/10289/2297.

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Flooding is a natural phenomenon and in the past Thai people have adapted to flood events. However over the years land degradation, deforestation and bad urban practices have exacerbated the impact of flood disasters. This study of flood management in Thailand shows how human activities and interventions have impacted on the river basin system. This research focuses on the vulnerability to flood hazard of the people living or working near the Chao Phraya River. The case study is of the community living or working in the proximity of Wat Bang Luang (Bang Luang Temple) of the Pathum Thani Prov

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Kailawadoko, Samuela Kannitha Chamroonsawasdi. "Smoking status among final year students at Ratchamonkon College, Nakorn Pathom, Thailand. /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/4537454.pdf.

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Jacob, Anand Simon. "Regulation of the PI 3-Kinase pathway and the RAS pathway in B Cell Receptor signaling /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486572165275679.

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Durbak, Amanda Rita. "Genetic Studies of CLAVATA Pathway Receptor Mutants Reveal Distinctions between Pathway Components in Meristems and Fruit." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/195699.

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The CLAVATA1 (CLV1), CLV2 and CORYNE (CRN) receptors egulate cell proliferation in shoot meristems through inhibition of WUSCHEL (WUS). Mutations in these receptors produce more floral organs. The prevailing model proposes that the extra organs are generated from enlarged floral meristems. Using forward and reverse genetics, I identified new alleles in clv1, clv2 and crn and found that most alleles only affect fruit organ number and not sepal, petal or stamen number. Analysis of inflorescence and floral meristems of clv1, clv2 and crn mutants revealed that most mutants do not have altered

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43

Schmitt, Christian. "Kinopathos grosse Gefühle im Gegenwartsfilm." Berlin Bertz + Fischer, 2008. http://d-nb.info/99403699X/04.

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Seiss, Melanie [Verfasser]. "Murrinh-Patha Complex Verbs : Syntactic Theory and Computational Implementation / Melanie Seiss." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1113109823/34.

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45

Perarnau, Vidal Dolors. "Søren Kierkegaard: el pathos del límit." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/321119.

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El propòsit de la tesi és llegir el pensament kierkegaardià des de la noció filosòfica de límit com a clau hermenèutica per a entendre’n tant el contingut com la forma. És des d’aquesta noció, fonamentalment definida per Kant des de la “frontera [Grenze]” de la raó i radicalment criticada per Hegel des del “moviment negatiu” de tota dialèctica, que Kierkegaard és vist com un pensador que, ultra assenyalar una infranquejable frontera entre la filosofia i el cristianisme, el que fa és esdevenir-la ell mateix. El que mirarem de mostrar, doncs, és com Kierkegaard, precisament pel fet de ser

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Krastanov, Stefan Vasilev. "Nietzsche: pathos artístico versus consciência moral." Universidade Federal de São Carlos, 2010. https://repositorio.ufscar.br/handle/ufscar/4773.

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Made available in DSpace on 2016-06-02T20:12:15Z (GMT). No. of bitstreams: 1 2951.pdf: 517548 bytes, checksum: e07be80ad08443f11e38b5a806d0112d (MD5) Previous issue date: 2010-02-26<br>The present work proposes an interpretation of the nietszchinian philosophy and, more specifically, of two fundamental and constitutive aspects of his thought, that are: the discussion about the language and the question about the tragic and the Greek tragedy. The reported interpretation is configured through a reading of split expressed as opposition between the artistic pathos and the ethical consciousne

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Rivera, Reyes Brenda Mariola. "Regulation of the TCR signaling pathway." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1132588714.

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48

Kaur, Dipendra. "Mapping and Filling Metabolic Pathway Holes." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_theses/14.

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The network-mapping tool integrated with protein database search can be used for filling pathway holes. A metabolic pathway under consideration (pattern) is mapped into a known metabolic pathway (text), to find pathway holes. Enzymes that do not show up in the pattern may be a hole in the pattern pathway or an indication of alternative pattern pathway. We present a data-mining framework for filling holes in the pattern metabolic pathway based on protein function, prosite scan and protein sequence homology. Using this framework we suggest several fillings found with the same EC notation, with g

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Presanis, Julia. "The lectin pathway of complement activation." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413519.

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50

Krarup, Anders. "The lectin pathway of complement activation." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:46255854-bfba-4d57-9185-3e6ed970a2db.

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Abstract:

The complement system is an important immune system mechanism involved in both the recognition and elimination of invading pathogens. It is activated by three different pathways: The classical pathway, which relies on binding of C1, and results in the cleavage of C4 and C2 through activation of C1r and C1s; the alternative pathway that relies on the spontaneous hydrolysis of C3 and the lectin pathway. The lectin pathway is activated by binding of Mannan-binding lectin (MBL) or the ficolins (L-ficolin, H-ficolin and M-ficolin) to microbial binding motifs, and the subsequent activation of the MB

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