Log in

Relevant bibliographies by topics / Pathogen adaptation / Journal articles

To see the other types of publications on this topic, follow the link: Pathogen adaptation.

Journal articles on the topic 'Pathogen adaptation'

Author: Grafiati

Published: 22 June 2024

Last updated: 19 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Pathogen adaptation.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Fonville, Judith M. "Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens." Journal of Virology 89, no. 18 (2015): 9242–51. http://dx.doi.org/10.1128/jvi.00832-15.

Full text

Abstract:

ABSTRACTAdaptation is a common theme in both pathogen emergence, for example, in zoonotic cross-species transmission, and pathogen control, where adaptation might limit the effect of the immune response and antiviral treatment. When such evolution requires deleterious intermediate mutations, fitness ridges and valleys arise in the pathogen's fitness landscape. The effect of deleterious intermediate mutations on within-host pathogen adaptation is examined with deterministic calculations, appropriate for pathogens replicating in large populations with high error rates. The effect of deleterious

APA, Harvard, Vancouver, ISO, and other styles

2

Sánchez-Vallet, Andrea, Simone Fouché, Isabelle Fudal, et al. "The Genome Biology of Effector Gene Evolution in Filamentous Plant Pathogens." Annual Review of Phytopathology 56, no. 1 (2018): 21–40. http://dx.doi.org/10.1146/annurev-phyto-080516-035303.

Full text

Abstract:

Filamentous pathogens, including fungi and oomycetes, pose major threats to global food security. Crop pathogens cause damage by secreting effectors that manipulate the host to the pathogen's advantage. Genes encoding such effectors are among the most rapidly evolving genes in pathogen genomes. Here, we review how the major characteristics of the emergence, function, and regulation of effector genes are tightly linked to the genomic compartments where these genes are located in pathogen genomes. The presence of repetitive elements in these compartments is associated with elevated rates of poin

APA, Harvard, Vancouver, ISO, and other styles

3

VanHook, Annalisa M. "Pathogen rewiring for host adaptation." Science 370, no. 6517 (2020): 677.20–679. http://dx.doi.org/10.1126/science.370.6517.677-t.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Slev, Patricia R., and Wayne K. Potts. "Disease consequences of pathogen adaptation." Current Opinion in Immunology 14, no. 5 (2002): 609–14. http://dx.doi.org/10.1016/s0952-7915(02)00381-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Lohia, Gaurav Kumar, and Sebastián A. Riquelme. "Pathogen adaptation to lung metabolites." Current Opinion in Microbiology 85 (June 2025): 102608. https://doi.org/10.1016/j.mib.2025.102608.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Laine, Anna-Liisa, Jeremy J. Burdon, Adnane Nemri, and Peter H. Thrall. "Host ecotype generates evolutionary and epidemiological divergence across a pathogen metapopulation." Proceedings of the Royal Society B: Biological Sciences 281, no. 1787 (2014): 20140522. http://dx.doi.org/10.1098/rspb.2014.0522.

Full text

Abstract:

The extent and speed at which pathogens adapt to host resistance varies considerably. This presents a challenge for predicting when—and where—pathogen evolution may occur. While gene flow and spatially heterogeneous environments are recognized to be critical for the evolutionary potential of pathogen populations, we lack an understanding of how the two jointly shape coevolutionary trajectories between hosts and pathogens. The rust pathogen Melampsora lini infects two ecotypes of its host plant Linum marginale that occur in close proximity yet in distinct populations and habitats. In this study

APA, Harvard, Vancouver, ISO, and other styles

7

Hanford, Hannah E., Juanita Von Dwingelo, and Yousef Abu Kwaik. "Bacterial nucleomodulins: A coevolutionary adaptation to the eukaryotic command center." PLOS Pathogens 17, no. 1 (2021): e1009184. http://dx.doi.org/10.1371/journal.ppat.1009184.

Full text

Abstract:

Through long-term interactions with their hosts, bacterial pathogens have evolved unique arsenals of effector proteins that interact with specific host targets and reprogram the host cell into a permissive niche for pathogen proliferation. The targeting of effector proteins into the host cell nucleus for modulation of nuclear processes is an emerging theme among bacterial pathogens. These unique pathogen effector proteins have been termed in recent years as “nucleomodulins.” The first nucleomodulins were discovered in the phytopathogensAgrobacteriumandXanthomonas, where their nucleomodulins fu

APA, Harvard, Vancouver, ISO, and other styles

8

Henschen, Amberleigh E., Michal Vinkler, Marissa M. Langager, et al. "Rapid adaptation to a novel pathogen through disease tolerance in a wild songbird." PLOS Pathogens 19, no. 6 (2023): e1011408. http://dx.doi.org/10.1371/journal.ppat.1011408.

Full text

Abstract:

Animal hosts can adapt to emerging infectious disease through both disease resistance, which decreases pathogen numbers, and disease tolerance, which limits damage during infection without limiting pathogen replication. Both resistance and tolerance mechanisms can drive pathogen transmission dynamics. However, it is not well understood how quickly host tolerance evolves in response to novel pathogens or what physiological mechanisms underlie this defense. Using natural populations of house finches (Haemorhous mexicanus) across the temporal invasion gradient of a recently emerged bacterial path

APA, Harvard, Vancouver, ISO, and other styles

9

TASARA, T., and R. STEPHAN. "Cold Stress Tolerance of Listeria monocytogenes: A Review of Molecular Adaptive Mechanisms and Food Safety Implications." Journal of Food Protection 69, no. 6 (2006): 1473–84. http://dx.doi.org/10.4315/0362-028x-69.6.1473.

Full text

Abstract:

The foodborne pathogen Listeria monocytogenes has many physiological adaptations that enable survival under a wide range of environmental conditions. The microbes overcome various types of stress, including the cold stress associated with low temperatures in food-production and storage environments. Cold stress adaptation mechanisms are therefore an important attribute of L. monocytogenes, enabling these food pathogens to survive and proliferate to reach minimal infectious levels on refrigerated foods. This phenomenon is a function of many molecular adaptation mechanisms. Therefore, an improve

APA, Harvard, Vancouver, ISO, and other styles

10

Zhao, Xin, Xinyu Li, Jiayi Gao, Shi Shen, and Wei Zou. "Behavioral adaptations of Caenorhabditis elegans against pathogenic threats." PeerJ 13 (April 14, 2025): e19294. https://doi.org/10.7717/peerj.19294.

Full text

Abstract:

This review examines the behavioral adaptation mechanisms of Caenorhabditis elegans in response to pathogenic bacterial threats, emphasizing their ecological significance. It systematically explores how mechanisms such as avoidance behavior, transgenerational learning, and forgetting enable C. elegans to optimize its survival and reproductive strategies within dynamic microbial environments. C. elegans detects harmful signals through chemosensation and initiates avoidance behaviors. Simultaneously, it manages environmental adaptation and energy allocation through transgenerational memory and f

APA, Harvard, Vancouver, ISO, and other styles

11

Fedderke, Johannes W., Robert E. Klitgaard, and Valerio Napolioni. "Genetic adaptation to historical pathogen burdens." Infection, Genetics and Evolution 54 (October 2017): 299–307. http://dx.doi.org/10.1016/j.meegid.2017.07.017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Hoque, M. Mozammel, Parisa Noorian, Gustavo Espinoza-Vergara, et al. "Adaptation to an amoeba host drives selection of virulence-associated traits in Vibrio cholerae." ISME Journal 16, no. 3 (2021): 856–67. http://dx.doi.org/10.1038/s41396-021-01134-2.

Full text

Abstract:

AbstractPredation by heterotrophic protists drives the emergence of adaptive traits in bacteria, and often these traits lead to altered interactions with hosts and persistence in the environment. Here we studied adaptation of the cholera pathogen, Vibrio cholerae during long-term co-incubation with the protist host, Acanthamoeba castellanii. We determined phenotypic and genotypic changes associated with long-term intra-amoebal host adaptation and how this impacts pathogen survival and fitness. We showed that adaptation to the amoeba host leads to temporal changes in multiple phenotypic traits

APA, Harvard, Vancouver, ISO, and other styles

13

Bidochka, Michael J., Susan Burke, and Luna Ng. "Extracellular hydrolytic enzymes in the fungal genus Verticillium: adaptations for pathogenesis." Canadian Journal of Microbiology 45, no. 10 (1999): 856–64. http://dx.doi.org/10.1139/w99-085.

Full text

Abstract:

The insect and plant pathogens within the fungal genus Verticillium showed enzymatic adaptation (production and regulation) directed to the degradation of some of the polymers found in the integument of their respective hosts. For example, the facultative plant pathogens (V. albo-atrum and V. dahliae) produced greater levels of cellulase and xylanase than the facultative insect pathogen (V. lecanii). Verticillium lecanii produced extracellular subtilisin-like protease when grown in insect cuticle medium but not in plant cell wall medium, while the plant pathogen V. albo-atrum showed a diminish

APA, Harvard, Vancouver, ISO, and other styles

14

Wu, E.-Jiao, Yan-Ping Wang, Li-Na Yang, Mi-Zhen Zhao, and Jiasui Zhan. "Elevating Air Temperature may Enhance Future Epidemic Risk of the Plant Pathogen Phytophthora infestans." Journal of Fungi 8, no. 8 (2022): 808. http://dx.doi.org/10.3390/jof8080808.

Full text

Abstract:

Knowledge of pathogen adaptation to global warming is important for predicting future disease epidemics and food production in agricultural ecosystems; however, the patterns and mechanisms of such adaptation in many plant pathogens are poorly understood. Here, population genetics combined with physiological assays and common garden experiments were used to analyze the genetics, physiology, and thermal preference of pathogen aggressiveness in an evolutionary context using 140 Phytophthora infestans genotypes under five temperature regimes. Pathogens originating from warmer regions were more the

APA, Harvard, Vancouver, ISO, and other styles

15

Mayer, Andreas, Thierry Mora, Olivier Rivoire, and Aleksandra M. Walczak. "Diversity of immune strategies explained by adaptation to pathogen statistics." Proceedings of the National Academy of Sciences 113, no. 31 (2016): 8630–35. http://dx.doi.org/10.1073/pnas.1600663113.

Full text

Abstract:

Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations—differences that may be essential to long-term survival. Here, we introduce a mathematical framework to compare the long-term adaptation of populations as a function of the pathogen dynamics that they experience and of the immune strategy that they adopt. We find that the two key determinants of an optimal immune strategy are the frequency and the characteri

APA, Harvard, Vancouver, ISO, and other styles

16

Dutta, Anik, Fanny E. Hartmann, Carolina Sardinha Francisco, Bruce A. McDonald, and Daniel Croll. "Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments." ISME Journal 15, no. 5 (2021): 1402–19. http://dx.doi.org/10.1038/s41396-020-00859-w.

Full text

Abstract:

AbstractThe adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growt

APA, Harvard, Vancouver, ISO, and other styles

17

Lloyd-Smith, James O. "Vacated niches, competitive release and the community ecology of pathogen eradication." Philosophical Transactions of the Royal Society B: Biological Sciences 368, no. 1623 (2013): 20120150. http://dx.doi.org/10.1098/rstb.2012.0150.

Full text

Abstract:

A recurring theme in the epidemiological literature on disease eradication is that each pathogen occupies an ecological niche, and eradication of one pathogen leaves a vacant niche that favours the emergence of new pathogens to replace it. However, eminent figures have rejected this view unequivocally, stating that there is no basis to fear pathogen replacement and even that pathogen niches do not exist. After exploring the roots of this controversy, I propose resolutions to disputed issues by drawing on broader ecological theory, and advance a new consensus based on robust mechanistic princip

APA, Harvard, Vancouver, ISO, and other styles

18

Råberg, Lars. "Human and pathogen genotype-by-genotype interactions in the light of coevolution theory." PLOS Genetics 19, no. 4 (2023): e1010685. http://dx.doi.org/10.1371/journal.pgen.1010685.

Full text

Abstract:

Antagonistic coevolution (i.e., reciprocal adaptation and counter-adaptation) between hosts and pathogens has long been considered an important driver of genetic variation. However, direct evidence for this is still scarce, especially in vertebrates. The wealth of data on genetics of susceptibility to infectious disease in humans provides an important resource for understanding host–pathogen coevolution, but studies of humans are rarely framed in coevolutionary theory. Here, I review data from human host–pathogen systems to critically assess the evidence for a key assumption of models of host–

APA, Harvard, Vancouver, ISO, and other styles

19

Langridge, Gemma C., Maria Fookes, Thomas R. Connor, et al. "Patterns of genome evolution that have accompanied host adaptation inSalmonella." Proceedings of the National Academy of Sciences 112, no. 3 (2014): 863–68. http://dx.doi.org/10.1073/pnas.1416707112.

Full text

Abstract:

Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which often reflect a balance between gene acquisition and functional gene loss. WithinSalmonella entericasubspeciesenterica, a single lineage exists that includes human and animal pathogens adapted to cause infection in different hosts, includingS. entericaserovar Enteritidis (multiple hosts),S.Gallinarum (birds), andS.Dublin (cattle). This provides an excellent evolutionary context in which differences b

APA, Harvard, Vancouver, ISO, and other styles

20

Cory, Jenny S., and Judith H. Myers. "Adaptation in an insect host-plant pathogen interaction." Ecology Letters 7, no. 8 (2004): 632–39. http://dx.doi.org/10.1111/j.1461-0248.2004.00617.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Koelle, Katia, Mercedes Pascual, and Md Yunus. "Pathogen adaptation to seasonal forcing and climate change." Proceedings of the Royal Society B: Biological Sciences 272, no. 1566 (2005): 971–77. http://dx.doi.org/10.1098/rspb.2004.3043.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

van Boven, Michiel, Frits R. Mooi, Joop F. P. Schellekens, Hester E. de Melker, and Mirjam Kretzschmar. "Pathogen adaptation under imperfect vaccination: implications for pertussis." Proceedings of the Royal Society B: Biological Sciences 272, no. 1572 (2005): 1617–24. http://dx.doi.org/10.1098/rspb.2005.3108.

Full text

Abstract:

Mass vaccination campaigns have drastically reduced the burden of infectious diseases. Unfortunately, in recent years several infectious diseases have re-emerged. Pertussis poses a well-known example. Inspired by pertussis, we study, by means of an epidemic model, the population and evolutionary dynamics of a pathogen population under the pressure of vaccination. A distinction is made between infection in immunologically naive individuals (primary infection) and infection in individuals whose immune system has been primed by vaccination or infection (secondary infection). The results show that

APA, Harvard, Vancouver, ISO, and other styles

23

Bourget, Romain, Loïc Chaumont, and Natalia Sapoukhina. "Timing of Pathogen Adaptation to a Multicomponent Treatment." PLoS ONE 8, no. 8 (2013): e71926. http://dx.doi.org/10.1371/journal.pone.0071926.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Harkins, Kelly M., and Anne C. Stone. "Ancient pathogen genomics: insights into timing and adaptation." Journal of Human Evolution 79 (February 2015): 137–49. http://dx.doi.org/10.1016/j.jhevol.2014.11.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

ZHAN, JIASUI, and BRUCE A. McDONALD. "Thermal adaptation in the fungal pathogen Mycosphaerella graminicola." Molecular Ecology 20, no. 8 (2011): 1689–701. http://dx.doi.org/10.1111/j.1365-294x.2011.05023.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Wang, Liyuan, Han Chen, JiangJiang Li, et al. "Effector gene silencing mediated by histone methylation underpins host adaptation in an oomycete plant pathogen." Nucleic Acids Research 48, no. 4 (2019): 1790–99. http://dx.doi.org/10.1093/nar/gkz1160.

Full text

Abstract:

Abstract The relentless adaptability of pathogen populations is a major obstacle to effective disease control measures. Increasing evidence suggests that gene transcriptional polymorphisms are a strategy deployed by pathogens to evade host immunity. However, the underlying mechanisms of transcriptional plasticity remain largely elusive. Here we found that the soybean root rot pathogen Phytophthora sojae evades the soybean Resistance gene Rps1b through transcriptional polymorphisms in the effector gene Avr1b that occur in the absence of any sequence variation. Elevated levels of histone H3 Lysi

APA, Harvard, Vancouver, ISO, and other styles

27

Tamisier, Lucie, Frédéric Fabre, Marion Szadkowski, et al. "Within-plant genetic drift to control virus adaptation to host-resistance genes." PLOS Pathogens 20, no. 8 (2024): e1012424. http://dx.doi.org/10.1371/journal.ppat.1012424.

Full text

Abstract:

Manipulating evolutionary forces imposed by hosts on pathogens like genetic drift and selection could avoid the emergence of virulent pathogens. For instance, increasing genetic drift could decrease the risk of pathogen adaptation through the random fixation of deleterious mutations or the elimination of favorable ones in the pathogen population. However, no experimental proof of this approach is available for a plant-pathogen system. We studied the impact of pepper (Capsicum annuum) lines carrying the same major resistance gene but contrasted genetic backgrounds on the evolution of Potato vir

APA, Harvard, Vancouver, ISO, and other styles

28

Sacristán, Soledad, Aurora Fraile, José M. Malpica, and Fernando García-Arenal. "An Analysis of Host Adaptation and Its Relationship with Virulence in Cucumber mosaic virus." Phytopathology® 95, no. 7 (2005): 827–33. http://dx.doi.org/10.1094/phyto-95-0827.

Full text

Abstract:

The host range of a pathogen can have special consequences on its evolution and the evolution of its virulence. For generalists, adaptation to different hosts may be conditioned by different trade-offs in the pathogen's life history and be affected by evolutionary processes that shape pathogen populations. We have examined adaptation of Cucumber mosaic virus (CMV) to different hosts, and analyzed the relationship between host adaptation and virulence. For this, six CMV isolates from central Spain from three different hosts were compared for the ability to multiply and to affect host growth. Th

APA, Harvard, Vancouver, ISO, and other styles

29

Précigout, Pierre-Antoine, Corinne Robert, and David Claessen. "Adaptation of Biotrophic Leaf Pathogens to Fertilization-Mediated Changes in Plant Traits: A Comparison of the Optimization Principle to Invasion Fitness." Phytopathology® 110, no. 5 (2020): 1039–48. http://dx.doi.org/10.1094/phyto-08-19-0317-r.

Full text

Abstract:

One of the conclusions of evolutionary ecology applied to agroecosystem management is that sustainable disease management strategies must be adaptive to overcome the immense adaptive potential of crop pathogens. In this context, knowledge of how pathogens adapt to changes in cultural practices is necessary. In this article we address the issue of the evolutionary response of biotrophic crop pathogens to changes in fertilization practices. For this purpose, we compare predictions of latent period evolution based on three empirical fitness measures (seasonal spore production, within-season expon

APA, Harvard, Vancouver, ISO, and other styles

30

Dawidziuk, A., G. Koczyk, and D. Popiel. "Adaptation and response to mycotoxin presence in pathogen-pathogen interactions within the Fusarium genus." World Mycotoxin Journal 9, no. 4 (2016): 565–75. http://dx.doi.org/10.3920/wmj2015.2010.

Full text

Abstract:

The ability of fungal plant pathogens to exude bioactive compounds is an important element of competition in a changing environment. The filamentous fungi usually retain a number of adaptations related not only to the production of toxic compounds by themselves but also to the mitigation of exogenous influences by toxins present in the environment. We examined a distinct effect of toxins on morphology, growth patterns and gene expression after stimulation in mycotoxin-producing and nonproducing isolates representing four evolutionarily divergent species (and chemotypes) within the Fusarium gen

APA, Harvard, Vancouver, ISO, and other styles

31

Baxter, Laura, Sucheta Tripathy, Naveed Ishaque, et al. "Signatures of Adaptation to Obligate Biotrophy in the Hyaloperonospora arabidopsidis Genome." Science 330, no. 6010 (2010): 1549–51. http://dx.doi.org/10.1126/science.1195203.

Full text

Abstract:

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR eff

APA, Harvard, Vancouver, ISO, and other styles

32

Goel, Ajay K., Derek Lundberg, Miguel A. Torres, et al. "The Pseudomonas syringae Type III Effector HopAM1 Enhances Virulence on Water-Stressed Plants." Molecular Plant-Microbe Interactions® 21, no. 3 (2008): 361–70. http://dx.doi.org/10.1094/mpmi-21-3-0361.

Full text

Abstract:

Pseudomonas syringae strains deliver diverse type III effector proteins into host cells, where they can act as virulence factors. Although the functions of the majority of type III effectors are unknown, several have been shown to interfere with plant basal defense mechanisms. Type III effectors also could contribute to bacterial virulence by enhancing nutrient uptake and pathogen adaptation to the environment of the host plant. We demonstrate that the type III effector HopAM1 (formerly known as AvrPpiB) enhances the virulence of a weak pathogen in plants that are grown under drought stress. T

APA, Harvard, Vancouver, ISO, and other styles

33

Fones, H. N., H. McCurrach, A. Mithani, J. A. C. Smith, and G. M. Preston. "Local adaptation is associated with zinc tolerance in Pseudomonas endophytes of the metal-hyperaccumulator plant Noccaea caerulescens." Proceedings of the Royal Society B: Biological Sciences 283, no. 1830 (2016): 20160648. http://dx.doi.org/10.1098/rspb.2016.0648.

Full text

Abstract:

Metal-hyperaccumulating plants, which are hypothesized to use metals for defence against pests and pathogens, provide a unique context in which to study plant–pathogen coevolution. Previously, we demonstrated that the high concentrations of zinc found in leaves of the hyperaccumulator Noccaea caerulescens provide protection against bacterial pathogens, with a potential trade-off between metal-based and pathogen-induced defences. We speculated that an evolutionary arms race between zinc-based defences in N. caerulescens and zinc tolerance in pathogens might have driven the development of the hy

APA, Harvard, Vancouver, ISO, and other styles

34

Keon, John, John Antoniw, Raffaella Carzaniga, et al. "Transcriptional Adaptation of Mycosphaerella graminicola to Programmed Cell Death (PCD) of Its Susceptible Wheat Host." Molecular Plant-Microbe Interactions® 20, no. 2 (2007): 178–93. http://dx.doi.org/10.1094/mpmi-20-2-0178.

Full text

Abstract:

Many important fungal pathogens of plants spend long periods (days to weeks) of their infection cycle in symptomless association with living host tissue, followed by a sudden transition to necrotrophic feeding as host tissue death occurs. Little is known about either the host responses associated with this sudden transition or the specific adaptations made by the pathogen to invoke or tolerate it. We are studying a major host-specific fungal pathogen of cultivated wheat, Septoria tritici (teleomorph Mycosphaerella graminicola). Here, we describe the host responses of wheat leaves infected with

APA, Harvard, Vancouver, ISO, and other styles

35

Dutta, Anik, Bruce A. McDonald, and Daniel Croll. "Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen." PLOS Pathogens 19, no. 11 (2023): e1011801. http://dx.doi.org/10.1371/journal.ppat.1011801.

Full text

Abstract:

Microbial pathogens often harbor substantial functional diversity driven by structural genetic variation. Rapid adaptation from such standing variation threatens global food security and human health. Genome-wide association studies (GWAS) provide a powerful approach to identify genetic variants underlying recent pathogen adaptation. However, the reliance on single reference genomes and single nucleotide polymorphisms (SNPs) obscures the true extent of adaptive genetic variation. Here, we show quantitatively how a combination of multiple reference genomes and reference-free approaches captures

APA, Harvard, Vancouver, ISO, and other styles

36

Ginger, Michael, and Mark C. Field. "Making the pathogen: Evolution and adaptation in parasitic protists." Molecular and Biochemical Parasitology 209, no. 1-2 (2016): 1–2. http://dx.doi.org/10.1016/j.molbiopara.2016.11.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Zhabokritsky, Alice, Meherzad Kutky, Lydia A. Burns, Rajita A. Karran, and Katalin A. Hudak. "RNA toxins: mediators of stress adaptation and pathogen defense." Wiley Interdisciplinary Reviews: RNA 2, no. 6 (2011): 890–903. http://dx.doi.org/10.1002/wrna.99.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Bauer, Michael, Sebastian Weis, Mihai G. Netea, and Reinhard Wetzker. "Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity." Trends in Immunology 39, no. 6 (2018): 438–45. http://dx.doi.org/10.1016/j.it.2018.04.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Kupfer, Tom R., and Daniel M. T. Fessler. "Ectoparasite defence in humans: relationships to pathogen avoidance and clinical implications." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1751 (2018): 20170207. http://dx.doi.org/10.1098/rstb.2017.0207.

Full text

Abstract:

Currently, disgust is regarded as the main adaptation for defence against pathogens and parasites in humans. Disgust's motivational and behavioural features, including withdrawal, nausea, appetite suppression and the urge to vomit, defend effectively against ingesting or touching sources of pathogens. However, ectoparasites do not attack their hosts via ingestion, but rather actively attach themselves to the body surface. Accordingly, by itself, disgust offers limited defence against ectoparasites. We propose that, like non-human animals, humans have a distinct ectoparasite defence system that

APA, Harvard, Vancouver, ISO, and other styles

40

TINSLEY, M. C., S. BLANFORD, and F. M. JIGGINS. "Genetic variation in Drosophila melanogaster pathogen susceptibility." Parasitology 132, no. 6 (2006): 767–73. http://dx.doi.org/10.1017/s0031182006009929.

Full text

Abstract:

Genetic variation in susceptibility to pathogens is a central concern both to evolutionary and medical biologists, and for the implementation of biological control programmes. We have investigated the extent of such variation in Drosophila melanogaster, a major model organism for immunological research. We found that within populations, different Drosophila genotypes show wide-ranging variation in their ability to survive infection with the entomopathogenic fungus Beauveria bassiana. Furthermore, striking divergence in susceptibility has occurred between genotypes from temperate and tropical A

APA, Harvard, Vancouver, ISO, and other styles

41

Geoghegan, Jemma L., Alistair M. Senior, and Edward C. Holmes. "Pathogen population bottlenecks and adaptive landscapes: overcoming the barriers to disease emergence." Proceedings of the Royal Society B: Biological Sciences 283, no. 1837 (2016): 20160727. http://dx.doi.org/10.1098/rspb.2016.0727.

Full text

Abstract:

Emerging diseases are a major challenge to public health. Revealing the evolutionary processes that allow novel pathogens to adapt to new hosts, also the potential barriers to host adaptation, is central to understanding the drivers of disease emergence. In particular, it is unclear how the genetics and ecology of pathogens interact to shape the likelihood of successful cross-species transmission. To better understand the determinants of host adaptation and emergence, we modelled key aspects of pathogen evolutionary dynamics at both intra- and inter-host scales, using parameter values similar

APA, Harvard, Vancouver, ISO, and other styles

42

Wendling, Carolin C., and K. Mathias Wegner. "Adaptation to enemy shifts: rapid resistance evolution to local Vibrio spp. in invasive Pacific oysters." Proceedings of the Royal Society B: Biological Sciences 282, no. 1804 (2015): 20142244. http://dx.doi.org/10.1098/rspb.2014.2244.

Full text

Abstract:

One hypothesis for the success of invasive species is reduced pathogen burden, resulting from a release from infections or high immunological fitness of invaders. Despite strong selection exerted on the host, the evolutionary response of invaders to newly acquired pathogens has rarely been considered. The two independent and genetically distinct invasions of the Pacific oyster Crassostrea gigas into the North Sea represent an ideal model system to study fast evolutionary responses of invasive populations. By exposing both invasion sources to ubiquitous and phylogenetically diverse pathogens (

APA, Harvard, Vancouver, ISO, and other styles

43

Liu, Wei, Shu-Hui Yu, Hong-Ping Zhang, et al. "Two Cladosporium Fungi with Opposite Functions to the Chinese White Wax Scale Insect Have Different Genome Characters." Journal of Fungi 8, no. 3 (2022): 286. http://dx.doi.org/10.3390/jof8030286.

Full text

Abstract:

Insects encounter infection of microorganisms, and they also harbor endosymbiosis to participate in nutrition providing and act as a defender against pathogens. We previously found the Chinese white wax scale insect, Ericerus pela, was infected and killed by Cladosporium sp. (pathogen). We also found it harbored Cladosporium sp. (endogensis). In this study, we cultured these two Cladosporium fungi and sequenced their genome. The results showed Cladosporium sp. (endogensis) has a larger genome size and more genes than Cladosporium sp. (pathogen). Pan-genome analysis showed Cladosporium sp. (end

APA, Harvard, Vancouver, ISO, and other styles

44

Dhillon, Braham, Nicolas Feau, Andrea L. Aerts, et al. "Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen." Proceedings of the National Academy of Sciences 112, no. 11 (2015): 3451–56. http://dx.doi.org/10.1073/pnas.1424293112.

Full text

Abstract:

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen,Mycosphaerella populorum, and the closely related poplar leaf pathogen,M. populicola. A secondary metabolite cluster unique toM. populorumis fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated i

APA, Harvard, Vancouver, ISO, and other styles

45

Hessenauer, Pauline, Nicolas Feau, Renate Heinzelmann, and Richard C. Hamelin. "Genomic exploration of climate-driven evolution and evolutionary convergence in forest pathogens." Genome Biology and Evolution, April 17, 2025. https://doi.org/10.1093/gbe/evaf069.

Full text

Abstract:

Abstract Climate significantly influences the distribution, composition, and diversity of fungal communities, impacting the growth, spread, and virulence of fungal forest pathogens. This study employs advanced landscape genomics methods to explore the genomic adaptations of three major fungal pathogens: those responsible for Dutch elm disease, dothistroma needle blight, and Swiss needle cast. Our findings reveal that precipitation and humidity are primary drivers of adaptation in these species. We use these insights to forecast potential adaptations under future climate scenarios (genomic offs

APA, Harvard, Vancouver, ISO, and other styles

46

Ahlawat, Neetika, Manas Geeta Arun, Komal Maggu, Jigisha, Aparajita Singh, and Nagaraj Guru Prasad. "Drosophila melanogaster hosts coevolving with Pseudomonas entomophila pathogen show sex-specific patterns of local adaptation." BMC Ecology and Evolution 22, no. 1 (2022). http://dx.doi.org/10.1186/s12862-022-02031-8.

Full text

Abstract:

Abstract Background In spatially structured populations, local adaptation improves organisms’ fitness in their native environment. Hosts and pathogens can rapidly adapt to their local antagonist. Since males and females can differ in their immunocompetence, the patterns of local adaptation can be different between the sexes. However, there is little information about sex differences in local adaptation in host–pathogen systems. Results In the current study, we experimentally coevolved four different replicate populations of Drosophila melanogaster (host) and Pseudomonas entomophila (pathogen)

APA, Harvard, Vancouver, ISO, and other styles

47

Liu, Shuai, Yanyan Li, Tingrui Song, et al. "The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases in the Han Chinese." Genomics, Proteomics & Bioinformatics, April 29, 2025. https://doi.org/10.1093/gpbjnl/qzaf038.

Full text

Abstract:

Abstract Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite their significance, investigating the pathogen-driven evolution of HLAs and the implications for autoimmune diseases presents considerable challenges. Here, we genotyped over twenty HLA genes at 3-field resolution in 8278 individuals from diverse ethnic backgrounds, including 4013 unrelated Han Chinese. We focused on the adaptation of HLAs in the Han Chinese by analyzing their binding affinity for various pathogens, and explored the potential co

APA, Harvard, Vancouver, ISO, and other styles

48

Yuen, Enoch Lok Him, Yasin Tumtas, Freddie King, et al. "A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion." Science Advances 10, no. 40 (2024). http://dx.doi.org/10.1126/sciadv.ado9516.

Full text

Abstract:

Pathogens have evolved sophisticated mechanisms to manipulate host cell membrane dynamics, a crucial adaptation to survive in hostile environments shaped by innate immune responses. Plant-derived membrane interfaces, engulfing invasive hyphal projections of fungal and oomycete pathogens, are prominent junctures dictating infection outcomes. Understanding how pathogens transform these host-pathogen interfaces to their advantage remains a key biological question. Here, we identified a conserved effector, secreted by plant pathogenic oomycetes, that co-opts a host Rab GTPase-activating protein (R

APA, Harvard, Vancouver, ISO, and other styles

49

Wilson, Hayley, Ido Bar, Kristy Hobson, Niloofar Vaghefi, Toni Petronitis, and Rebecca Ford. "Integrated Disease Management, Adaptation and Genomics of Fungal Plant Pathogens in Cropping Systems." Plant Pathology, May 12, 2025. https://doi.org/10.1111/ppa.14114.

Full text

Abstract:

ABSTRACTCrop production systems contribute significantly to maintaining global food security. These systems often involve the cultivation of single cultivars in highly homogenised environments to meet demands. Agriculturally important plant fungal pathogens can be destructive constraints in such systems. Integrated disease management strategies comprising the tactical use of cultural, chemical and host genetic controls are deployed to reduce the impact of plant pathogens. The homogenous nature of these cropping systems combined with evolutionary forces on the often‐flexible fungal genome incre

APA, Harvard, Vancouver, ISO, and other styles

50

Hessenauer, Pauline, Nicolas Feau, Upinder Gill, Benjamin Schwessinger, Gurcharn S. Brar, and Richard C. Hamelin. "Evolution and Adaptation of Forest and Crop Pathogens in the Anthropocene." Phytopathology®, December 18, 2020, PHYTO—08–20–035. http://dx.doi.org/10.1094/phyto-08-20-0358-fi.

Full text

Abstract:

Anthropocene marks the era when human activity is making a significant impact on earth, its ecological and biogeographical systems. The domestication and intensification of agricultural and forest production systems have had a large impact on plant and tree health. Some pathogens benefitted from these human activities and have evolved and adapted in response to the expansion of crop and forest systems, resulting in global outbreaks. Global pathogen genomics data including population genomics and high-quality reference assemblies are crucial for understanding the evolution and adaptation of pat

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!