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Relevant bibliographies by topics / Pathogen genomics

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Academic literature on the topic 'Pathogen genomics'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 April 2022

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Journal articles on the topic "Pathogen genomics"

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Sánchez-Vallet, Andrea, Simone Fouché, Isabelle Fudal, et al. "The Genome Biology of Effector Gene Evolution in Filamentous Plant Pathogens." Annual Review of Phytopathology 56, no. 1 (2018): 21–40. http://dx.doi.org/10.1146/annurev-phyto-080516-035303.

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Filamentous pathogens, including fungi and oomycetes, pose major threats to global food security. Crop pathogens cause damage by secreting effectors that manipulate the host to the pathogen's advantage. Genes encoding such effectors are among the most rapidly evolving genes in pathogen genomes. Here, we review how the major characteristics of the emergence, function, and regulation of effector genes are tightly linked to the genomic compartments where these genes are located in pathogen genomes. The presence of repetitive elements in these compartments is associated with elevated rates of poin

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Cameron, Andrew, Jessica L. Bohrhunter, Samantha Taffner, Adel Malek, and Nicole D. Pecora. "Clinical Pathogen Genomics." Clinics in Laboratory Medicine 40, no. 4 (2020): 447–58. http://dx.doi.org/10.1016/j.cll.2020.08.003.

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Dow, J. M., and M. J. Daniels. "Xylella Genomics and Bacterial Pathogenicity to Plants." Yeast 1, no. 4 (2000): 263–71. http://dx.doi.org/10.1155/2000/372461.

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Xylella fastidiosa, a pathogen of citrus, is the first plant pathogenic bacterium for which the complete genome sequence has been published. Inspection of the sequence reveals high relatedness to many genes of other pathogens, notably Xanthomonas campestris. Based on this, we suggest that Xylella possesses certain easily testable properties that contribute to pathogenicity. We also present some general considerations for deriving information on pathogenicity from bacterial genomics.

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Klosterman, S. J., J. R. Rollins, M. R. Sudarshana, and B. A. Vinatzer. "Disease Management in the Genomics Era—Summaries of Focus Issue Papers." Phytopathology® 106, no. 10 (2016): 1068–70. http://dx.doi.org/10.1094/phyto-07-16-0276-fi.

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The genomics revolution has contributed enormously to research and disease management applications in plant pathology. This development has rapidly increased our understanding of the molecular mechanisms underpinning pathogenesis and resistance, contributed novel markers for rapid pathogen detection and diagnosis, and offered further insights into the genetics of pathogen populations on a larger scale. The availability of whole genome resources coupled with next-generation sequencing (NGS) technologies has helped fuel genomics-based approaches to improve disease resistance in crops. NGS techno

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Gibriel, Hesham A. Y., Bart P. H. J. Thomma, and Michael F. Seidl. "The Age of Effectors: Genome-Based Discovery and Applications." Phytopathology® 106, no. 10 (2016): 1206–12. http://dx.doi.org/10.1094/phyto-02-16-0110-fi.

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Microbial pathogens cause devastating diseases on economically and ecologically important plant species, threatening global food security, and causing billions of dollars of losses annually. During the infection process, pathogens secrete so-called effectors that support host colonization, often by deregulating host immune responses. Over the last decades, much of the research on molecular plant-microbe interactions has focused on the identification and functional characterization of such effectors. The increasing availability of sequenced plant pathogen genomes has enabled genomics-based disc

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Armstrong, Gregory L., Duncan R. MacCannell, Jill Taylor, et al. "Pathogen Genomics in Public Health." New England Journal of Medicine 381, no. 26 (2019): 2569–80. http://dx.doi.org/10.1056/nejmsr1813907.

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Armstrong, Gregory L., Duncan R. MacCannell, Jill Taylor, et al. "Pathogen Genomics in Public Health." Obstetrical & Gynecological Survey 75, no. 5 (2020): 275–76. http://dx.doi.org/10.1097/01.ogx.0000666232.13540.20.

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Moxon, Richard, and Rino Rappuoli. "Bacterial pathogen genomics and vaccines." British Medical Bulletin 62, no. 1 (2002): 45–58. http://dx.doi.org/10.1093/bmb/62.1.45.

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Raskin, David M., Rekha Seshadri, Stefan U. Pukatzki, and John J. Mekalanos. "Bacterial Genomics and Pathogen Evolution." Cell 124, no. 4 (2006): 703–14. http://dx.doi.org/10.1016/j.cell.2006.02.002.

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Rausell, Antonio, and Amalio Telenti. "Genomics of host–pathogen interactions." Current Opinion in Immunology 30 (October 2014): 32–38. http://dx.doi.org/10.1016/j.coi.2014.06.001.

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Dissertations / Theses on the topic "Pathogen genomics"

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Almiman, Bandar F. "Molecular genetic and genomic characterization of an emerging mycotoxigenic pathogen Fusarium proliferatum." Thesis, University of Bedfordshire, 2018. http://hdl.handle.net/10547/622835.

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This aim of this research was to elucidate the genotypic diversity of the mycotoxigenic species Fusarium proliferatum associated with diverse hosts and distributed in wide geographic locations to gain new insights into the biology of this emerging pathogen. This study developed a novel molecular genetic marker FG1056. Multilocus typing of F. proliferatum isolates (52) using F. verticillioides (2) and F. oxysporum (3) as references was carried out with FG1056 and a set of known genetic markers (ITS, TEF1, CAL and FUM1). This distinguished up to 10 genetic groups, 2 clusters and 23 haplotypes am

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Carreté, Muñoz Laia 1990. "Population genomics of the emerging yeast pathogen Candida glabrata." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/587199.

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Infections caused by pathogenic fungi are becoming an increasingly serious threat for human health. Pathogenic fungi such as Candida glabrata or Candida albicans, belong to phylogenetically distinct clades and have non-pathogenic close relatives, indicating that the ability to infect humans has evolved several times independently. Despite the many recent advances in biomedicine, we are still lacking an understanding of how virulence evolves across organisms and which mechanisms are involved in the emergence of pathogenesis. Elucidating how human pathogens evolve is of central relevance to unde

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Lee, Kevin Joseph. "Transcriptomics of malaria host-pathogen interactions in primates." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54264.

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Malaria is a pernicious disease that has greatly impacted and continues to affect the human population. While much research has been performed to understand the underlying nature of this disease, gaps in the knowledge-base persist. In order to address these deficiencies, a multi-disciplinary, multi-institutional project has been funded to study the systems biology of the host pathogen interaction during malaria infection in both humans and non-human primates. In the course of investigating the transcriptome during two 100-day experiments in Macaca mulatta, this work elucidated many of the u

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Watson, Michael Bryan. "Bioinformatic analysis of genome-scale data reveals insights into host-pathogen interactions in farm animals." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19540.

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This thesis documents the contribution of my bioinformatics research activities, including novel software development, to a range of research projects aimed at investigating the interactions between bacterial and viral pathogens and their hosts. The focus is largely on farm animal species and their pathogens, although some of the research has a wider scientific impact. RNA interference (RNAi) refers to a variety of related regulatory pathways present in animals, plants and insects. The major pathways are microRNAs (miRNAs), small-interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs). Ma

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Bai, Xiaodong. "Insect transmitted plant pathogenic mollicutes, Spiroplasma kunkelii and aster yellows witches' broom phytoplasma from structural genomics to functional genomics /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101752677.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 232 p.; also includes graphics (some col.). Includes bibliographical references (p. 206-232).

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Sturgill, David Matthew. "Comparative Genome Analysis of Three Brucella spp. and a Data Model for Automated Multiple Genome Comparison." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/10163.

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Comparative analysis of multiple genomes presents many challenges ranging from management of information about thousands of local similarities to definition of features by combination of evidence from multiple analyses and experiments. This research represents the development stage of a database-backed pipeline for comparative analysis of multiple genomes. The genomes of three recently sequenced species of Brucella were compared and a superset of known and hypothetical coding sequences was identified to be used in design of a discriminatory genomic cDNA array for comparative functional genomic

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Gonen, Serap. "Mapping and functional characterisation of the Atlantic salmon genome and its regulation of pathogen response." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19518.

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Atlantic salmon is a species of both scientific and economic importance, and Atlantic salmon farming is a highly profitable industry worldwide. One of the biggest challenges being faced by farms, which affects production efficiency and results in severe economic loss, is disease. In livestock production, one of the approaches taken to limit the impact of disease outbreaks is to selectively breed for improved resistance within farmed populations. Although traditional family-based resistance breeding programs have shown improvements in resistance to a variety of bacterial, viral and parasitic di

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Torres, Maria F. "Cellular and molecular aspects of the interaction betwen maize and the anthracnose pathogen Colletotrichum graminicola." UKnowledge, 2013. http://uknowledge.uky.edu/plantpath_etds/7.

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Maize anthracnose, caused by the fungus Colletotrichum graminicola, is an economically important species contributing to major yield losses. C. graminicola is a hemibiotroph; initially it invades its host while it is alive, and then it switches to destructive necrotrophic growth and the host is killed. Establishment of compatible interactions by biotrophic pathogens is usually associated with suppression of host defenses and cell death, while necrotrophic pathogens typically secrete phytotoxic compounds and induce cell death. To understand the relationship of hemibiotrophy in C. graminicola to

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Wax, Noah David. "Comparative genomics of bacteria from amphibian skin associated with inhibition of an amphibian fungal pathogen Batrachochytrium dendrobatidis." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103961.

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Chytridiomycosis is a fungal skin disease in amphibians that is primarily caused by Batrachochytrium dendrobatidis (Bd). We analyzed whole genome sequences of 40 bacterial isolates that had been previously cultured from the skin of four amphibian species from Virginia, USA, and tested for their ability to inhibit Bd growth via an in vitro challenge assay. These 40 isolates spanned 11 families and 13 genera. The aim of this study was to identify genomic differences among the amphibian skin bacterial isolates and generate hypotheses about possible differences that could contribute to variation i

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Hossain, A. S. Md Mukarram. "Scalable tools for high-throughput viral sequence analysis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/276228.

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Viral sequence data are increasingly being used to estimate evolutionary and epidemiological parameters to understand the dynamics of viral diseases. This thesis focuses on developing novel and improved computational methods for high-throughput analysis of large viral sequence datasets. I have developed a novel computational pipeline, Pipelign, to detect potentially unrelated sequences from groups of viral sequences during sequence alignment. Pipelign detected a large number of unrelated and mis-annotated sequences from several viral sequence datasets collected from GenBank. I subsequently dev

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Books on the topic "Pathogen genomics"

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Shaw, Karen Joy, ed. Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5.

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Wiedmann, Martin, and Wei Zhang. Genomics of foodborne bacterial pathogens. Springer, 2011.

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Deng, Xiangyu, Henk C. den Bakker, and Rene S. Hendriksen, eds. Applied Genomics of Foodborne Pathogens. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-43751-4.

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Wiedmann, Martin, and Wei Zhang, eds. Genomics of Foodborne Bacterial Pathogens. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-7686-4.

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Capretti, Paolo, Cecilia Comparini, Matteo Garbelotto, and Nicola La Porta, eds. XIII Conference "Root and Butt Rot of Forest Trees" IUFRO Working Party 7.02.01. Firenze University Press, 2013. http://dx.doi.org/10.36253/978-88-6655-353-3.

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The present Proceedings comprise the contributions that were presented at the 13th International Conference of the IUFRO W. Party 7.02.01 “Root and Butt Rot of Forest Trees” that was held in Italy from the 4th to the 10th of September 2011. The Conference started in Firenze than moved to FEM Research Centre, S. Michele all’Adige, Trento and continued in San Martino di Castrozza, Dolomite region. Root and Butt Rot of Forest Trees have a high biological and economic impact in forestry. The Proceedings were organized under seven headings: Genomics and Plant-Pathogen Interactions; Systematics, Tax

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Dean, Ralph A., Ann Lichens-Park, and Chittaranjan Kole, eds. Genomics of Plant-Associated Fungi: Monocot Pathogens. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44053-7.

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Dean, Ralph A., Ann Lichens-Park, and Chittaranjan Kole, eds. Genomics of Plant-Associated Fungi and Oomycetes: Dicot Pathogens. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44056-8.

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Fratamico, Pina, Yanhong Liu, and Sophia Kathariou, eds. Genomes of Foodborne and Waterborne Pathogens. ASM Press, 2010. http://dx.doi.org/10.1128/9781555816902.

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Pathogenic Neisseria: Genomics, molecular biology and disease intervention. Caister Academic Press, 2014.

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Fatmi, M'Barek. Pseudomonas syringae Pathovars and Related Pathogens – Identification, Epidemiology and Genomics. Springer Science + Business Media, B.V, 2008.

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Book chapters on the topic "Pathogen genomics"

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Shearer, Glenmore. "Functional Genomics of Histoplasma capsulatum." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_15.

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Früh, Klaus, and Peter Ghazal. "Antiviral Drug Target Discovery with DNA Microarrays." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_1.

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Shamaei-Tousi, Alireza, and Sven Bergström. "Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_10.

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DiDomenico, Beth, and Scott S. Walker. "Antifungal Target Discovery and Evaluation." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_11.

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Backer, Marianne D., Walter H. M. L. Luyten, and Hugo F. Bossche. "Antifungal Drug Discovery: Old Drugs, New Tools." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_12.

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Lodge, Jennifer K., and John R. Perfect. "Cryptococcus neoformans." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_13.

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Pena-Muralla, Rosanna, Patricia Ayoubi, Marcia Graminha, Nilce M. Martinez-Rossi, Antonio Rossi, and Rolf A. Prade. "Antifungal Target Selection in Aspergillus nidulans." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_14.

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Kirkland, Theo N., and Garry T. Cole. "Gene-Finding in Coccidioides immitis." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_16.

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Kissinger, Jessica C., Michael J. Crawford, David S. Roos, and James W. Ajioka. "Toxoplasma gondii." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_17.

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Rought, Steffney Elise, Roman Sasik, Davey Mitchell Smith, and Jacques Corbeil. "Chipping Away at HIV Pathogenesis." In Pathogen Genomics. Humana Press, 2002. http://dx.doi.org/10.1007/978-1-59259-172-5_2.

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Conference papers on the topic "Pathogen genomics"

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Carpi, Giovanna. "The role of pathogen genomics in assessing tick-borne pathogen evolutionary dynamics." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.105334.

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"Strategy of genetic protection of common spring wheat from leaf rust in Southern Ural due to changes pathogen population structures." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-200.

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"Generalization of the results on the effect of selenium nanocomposites on the interaction of potatoes with the ring rot disease pathogen." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Novosibirsk ICG SB RAS 2021, 2021. http://dx.doi.org/10.18699/plantgen2021-153.

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Grad, Y. "PL10 Using pathogen population genomics to study the evolution, spread, and antibiotic resistance of STIs." In Abstracts for the STI & HIV World Congress, July 14–17 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/sextrans-2021-sti.10.

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"Molecular screening of wheat entries for resistance to the toxins Ptr ToxA and Ptr ToxB from the tan spot pathogen Pyrenophora tritici-repentis." In Current Challenges in Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Novosibirsk State University, 2019. http://dx.doi.org/10.18699/icg-plantgen2019-20.

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Kopacz, Adrian M., Wing K. Liu, and Jae-Hyun Chung. "Design and Optimization of a Nanotip Sensor via Immersed Molecular Electrokinetic Finite Element Method." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13299.

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A critical challenge in the field of medicine is to develop a low cost sensor competent of detecting specific bacterial pathogens via a precise deoxyribonucleic acid (DNA) sequence. In order to identify such biological agents in a patient’s blood or other bodily fluids at the onset of infection, detection of specific pathogen genomic DNA is considered a reliable approach. Current techniques involving multiplex DNA/RNA detection arrays or immunoassays [1] require cumbersome sample preparation, aggressive nucleic acid amplification protocols and must be operated by trained personnel. To overcome

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Cristea, Paul Dan. "Genomic signal analysis of pathogen variability." In Biomedical Optics 2006, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2006. http://dx.doi.org/10.1117/12.644034.

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"Polymorphism of flax pathogens assessed using deep sequencing." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-127.

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"SSR profiling of potato cultivars resistant to pathogens." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Novosibirsk ICG SB RAS 2021, 2021. http://dx.doi.org/10.18699/plantgen2021-072.

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Cristea, Paul Dan. "Genomic signal analysis: Study of pathogen variability." In 2006 IEEE International Workshop on Genomic Signal Processing and Statistics. IEEE, 2006. http://dx.doi.org/10.1109/gensips.2006.353151.

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Reports on the topic "Pathogen genomics"

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Yuen, Gary, Serge Edme, Gautam Sarath, Nathan Palmer, Satyanarayana Tatineni, and Robert Mitchell. Genetics and Genomics of Pathogen Resistance in Switchgrass. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1783170.

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Avni, Adi, and Kirankumar S. Mysore. Functional Genomics Approach to Identify Signaling Components Involved in Defense Responses Induced by the Ethylene Inducing Xyalanase Elicitor. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7697100.bard.

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Plant-microbe interactions involve a large number of global regulatory systems, which are essential for plants to protect themselves against pathogen attack. An ethylene-inducing xylanase (EIX) of Trichoderma viride is a potent elicitor of plant defense responses, like hypersensitive response (HR), in specific cultivars of tobacco (Nicotiana tabacum) and tomato (Lycopersicon esculentum). The central goal of this proposal was to investigate the molecular mechanisms that allow plants to specifically activate defense responses after EIX treatment. We proposed to identify cellular signaling compon

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Sessa, Guido, and Gregory Martin. A functional genomics approach to dissect resistance of tomato to bacterial spot disease. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695876.bard.

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The research problem. Bacterial spot disease in tomato is of great economic importance worldwide and it is particularly severe in warm and moist areas affecting yield and quality of tomato fruits. Causal agent of spot disease is the Gram-negative bacterium Xanthomonas campestris pv. vesicatoria (Xcv), which can be a contaminant on tomato seeds, or survive in plant debris and in association with certain weeds. Despite the economic significance of spot disease, plant protection against Xcvby cultural practices and chemical control have so far proven unsuccessful. In addition, breeding for resist

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Sela, Hanan, Eduard Akhunov, and Brian J. Steffenson. Population genomics, linkage disequilibrium and association mapping of stripe rust resistance genes in wild emmer wheat, Triticum turgidum ssp. dicoccoides. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598170.bard.

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The primary goals of this project were: (1) development of a genetically characterized association panel of wild emmer for high resolution analysis of the genetic basis of complex traits; (2) characterization and mapping of genes and QTL for seedling and adult plant resistance to stripe rust in wild emmer populations; (3) characterization of LD patterns along wild emmer chromosomes; (4) elucidation of the multi-locus genetic structure of wild emmer populations and its correlation with geo-climatic variables at the collection sites. Introduction In recent years, Stripe (yellow) rust (Yr) caused

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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused

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Borucki, M. Task 1.5 Genomic Shift and Drift Trends of Emerging Pathogens. Office of Scientific and Technical Information (OSTI), 2010. http://dx.doi.org/10.2172/972402.

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Freeman, Stanley, and Russell J. Rodriguez. The Interaction Between Nonpathogenic Mutants of Colletotrichum and Fusarium, and the Plant Host Defense System. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7573069.bard.

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The intent of this proposal was to study the interaction between nonpathogenic mutants of Colletotrichum magna and Fusarium oxysporum, and the cucurbit host defense system. We had shown previously that a nonpathogenic endophytic mutant path- 1 of C. magna, caused no visible disease symptoms but protected watermelon seedlings from disease caused by the wildtype isolate and F. o. niveum. Objectives were: 1) Determine the microscopic, biochemical and molecular genetic interaction between "protected" (path- 1 colonized) cucurbit hosts and wildtype isolates of C. magna; 2) Isolate non-pathogenic mu

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Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed

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Dickman, Martin B., and Oded Yarden. Genetic and chemical intervention in ROS signaling pathways affecting development and pathogenicity of Sclerotinia sclerotiorum. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7699866.bard.

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Abstract:

Abstract: The long-term goals of our research are to understand the regulation of sclerotial development and pathogenicity in S. sclerotior11111. The focus in this project was on the elucidation of the signaling events and environmental cues involved in the regulation of these processes, utilizing and continuously developing tools our research groups have established and/or adapted for analysis of S. sclerotiorum, Our stated objectives: To take advantage of the recent conceptual (ROS/PPs signaling) and technical (amenability of S. sclerotiorumto manipulations coupled with chemical genomics and

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