To see the other types of publications on this topic, follow the link: Pathological jaundice.
Journal articles on the topic 'Pathological jaundice'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Pathological jaundice.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Monintja, H. E., B. Wirastari, N. Kadri, A. Aminullah, and S. Muslichan. "Problems of Neonatal Jaundice in Indonesia." Paediatrica Indonesiana 19, no. 3-4 (June 16, 2017): 63. http://dx.doi.org/10.14238/pi19.3-4.1979.63-71.
Full textAbstract:
This study revealed the incidence of neonatal jaundice in the Dr. Cipto Mangunkusumo Hospital Jakarta to be 32.1%, i.e 42.97% in low birth weight infants and 29.70% in fulllerm infants. No pathological basis was proven in many cases. The factors which may cause pathological jaundice according to the frequency are as follows: infections, anoxia and hypoxia, hemolysis due to G6PD deficiency, multiple factors and hypoglycemia etc. This study also revealed that 69.5% of jaundiced infants had bilirubin concentration of more than 10 mg%. Analysis of the factors showed that most of them were preventable.
2
N. Kamal, Ayia, and Ali F. Hassan. "Comparative Study of Liver Function and Rh Blood Group between both Physiological and Pathological Neonatal Jaundice." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (June 15, 2021): 101–9. http://dx.doi.org/10.31351/vol30iss1pp101-109.
Full textAbstract:
Abstract
Backgrounds: Jaundice occurs in most newborn due to increased bilirubin concentration. Jaundice is observed during the first week after birth in approximately 60% of term neonates. A high level of bilirubin is neurotoxic and may cause neonatal kernicterus, auditory neuropathy or death.
Objectives: to compare the Rh group compatibility, serum bilirubin (total and direct), serum albumin and several liver enzymes between physiological and pathological neonatal jaundice
Materials and Methods: A cross sectional study for one hundred neonates with jaundice divided into group 1: 50 newborns with physiological jaundice, Group 2: 50 newborns with pathological jaundice. Blood samples taken from each patient use to determination of Rh Group and blood group, serum bilirubin (total and direct, liver enzymes and albumin concentration. Results: in the present study Rh Compatibility show a significant relationship between newborns with physiological and pathological jaundice (p<0.05). Serum bilirubin (total and direct), serum albumin concentration and several liver enzymes were significantly higher when compare newborns with pathological jaundice with newborns of physiological jaundice (p<0.05).
Conclusion: these finding demonstrate that newborns with pathological jaundice have higher concentrations of these parameters as compared with physiological jaundice .
3
PRASETYO, DENNY, OKKY PRASETYO, and ERNY ERNY. "Deskripsi Pencegahan Ikterus Neonatorum Patologis Ditinjau dari Pemahaman Proses Metabolisme Bilirubin Di RSU Muhamadiyah Gresik." Hang Tuah Medical journal 17, no. 1 (November 12, 2019): 1. http://dx.doi.org/10.30649/htmj.v17i1.191.
Full textAbstract:
<p><strong>ABSTRACT</strong><strong></strong></p><p class="15">Neonatal jaundice is a condition characterized by yellow staining of the skin and eye sclera and is commonly found in babies, especially in preterm infant. Neonatal jaundice must be wary of because the pathological type can aggravate and cause ikterus ensefalopati with permanent severe disability. Method : Descriptive research during April to June 2019 at Muhammadiyah Hospital Gresik with a population of all infants with neonatal jaundice by recording all risk faktors for neonatal jaundice. Results : for 3 months, 19 cases of pathological neonatal jaundice were found in 722 deliveries (2.6%) with 52.7% of cases having risk faktors based on an understanding of the process of bilirubin metabolisme. Conclusion : risk faktors for neonatal ikterus can be reviewed and arranged based on an understanding of the process of bilirubin metabolisme and it is strongly recommended to look for every pregnant woman to detect the possibility of pathological neonatal ikterus, prevent with good education and arrange comprehensive management to prevent ikterus ensefalopati</p><p class="15"> </p><p class="15">Keywords : pathologic neonatal jaundice, General Hospital Muhammadiyah Gresik, bilirubin metabolisme</p>
4
Bhat, Jehangir Allam, and Roshan Ara. "Correlation of cord blood albumin values with neonatal jaundice in health new-borns: a prospective observational study." International Journal of Contemporary Pediatrics 6, no. 2 (February 23, 2019): 634. http://dx.doi.org/10.18203/2349-3291.ijcp20190702.
Full textAbstract:
Background: The objective of the present study was to investigate the predictability of pathological jaundice on cord blood albumin values.Methods: It was a prospective observation study conducted in Kurji holy family hospital on 289 healthy new-borns. Babies were divided into two groups. Group A who developed physiological jaundice and group B who developed pathological jaundice. Cord blood albumin was estimated in all new-born who were then followed up-to 5th day of life. Babies who developed jaundice requiring treatment were admitted in NICU for phototherapy. Rest where checked regularly up-to 5th day of life and value recorded on 5th day by estimation of serum albumin.Results: Incidence of pathological hyperalbuminemia in present study was 11.2%. There was statistically significant correlation between cord blood albumin and development of pathological jaundice. Gender, age, mode of delivery and birth weight has no correlation with cord albumin and the subsequent development of jaundice. Cord blood albumin <3.5mg/dl when compared with subsequent development of jaundice has high specificity (83.92%) and negative predictive value (87.35%). Cord blood value of >2.5mg/dl has high sensitivity (97.06%), specificity (99.22%), Positive predictive value (94.29%) and negative predictive value (99.61%) in predicting future development of pathological jaundice.Conclusions: The 87.35% negative predictive value in the present study suggests that in healthy term babies (Cord blood albumin ≤3.5mg/dl) cord serum albumin can help to identify those new-borns who are unlikely to require further evaluation and intervention. These new-borns can be discharged with assurance to parents. Babies with CBA level <2.5mg/dl should be followed more frequently. Thus, this study concludes that cord blood total albumin levels reliably predict the occurrence of pathological hyperalbuminemia.
5
Kalraiya, Ashish, Pankaj Gyanani, Shiv Ram Krishna Dubey, Vijaya Beohar, and Pramila Verma. "Clinico-etiological profile of neonates admitted with jaundice in a tertiary care NICU of Central India." International Journal of Contemporary Pediatrics 5, no. 3 (April 20, 2018): 1049. http://dx.doi.org/10.18203/2349-3291.ijcp20181540.
Full textAbstract:
Background: Hyperbilirubinemia is a common problem and, in most cases, a benign problem in neonates. Jaundice is observed during the 1st week of life in approximately 60% of term infants and 80% of preterm infants.Methods: In present study, total 187 newborns were enrolled prospectively over one and half year of study period from November 2015 to April 2017. Detailed patient information was taken at the time of admission in NICU. In this study all the newborns with age less than 28 days were included who had clinical jaundice, ascertained by Kramer’s criteria and confirmed by biochemical methods. The investigations done were Serum bilirubin (total, direct and indirect) complete blood picture, reticulocyte count, G6-PD estimation (qualitative), Coombs' test, peripheral smear examination, blood group (ABO,Rh) of the mother and baby, CBC,CRP, thyroid function test.Results: Total 187 newborns were enrolled for study. Maximum number of the babies have a pathological jaundice 108 (57.7%) whereas 79 (42.24%) were found to have exaggerated physiological jaundice. The commonest causes of pathological jaundice were found to be septicemia 63 (33.68%) followed by ABO incompatibility 25 (13.36%). Most of the babies had onset of jaundice between 24-72 hours (86.6%).Conclusions: Health care providers working with neonates play a key role in identifying and assessing neonates at risk for pathologic jaundice. Parents counseling is required for bringing their babies early to healthcare centre preventing acute bilirubin encephalopathy and subsequent kernicterus.
6
R., Vikram, and C. S. Balachandran. "Study of hematological indices in neonates admitted with non-obstructive jaundice and its outcome in a tertiary care hospital." International Journal of Contemporary Pediatrics 4, no. 5 (August 23, 2017): 1827. http://dx.doi.org/10.18203/2349-3291.ijcp20173794.
Full textAbstract:
Background: To study non-obstructive causes and laboratory profile of neonatal hyperbilirubinemia. Design: prospective study.Methods: Selection of cases were done from routine cases reporting to newborn unit in the department of paediatrics, with clinical evidence of jaundice in neonates. Blood group of the mother and baby, Serum bilirubin estimation, Complete blood count with peripheral smear examination, Reticulocyte count, Direct coomb’s test and C-reactive protein of the baby were done.Results: Study includes 89 cases of newborn admitted in our tertiary care institute. Out of 89 neonates, 52 (58.42%) were male while 37 (41.57%) were females. Total number of Pre-term babies was 35 (39.32%). Neonates having low birth weight were 30 (33.7%) and very low birth were 10 (11.23%). Physiological jaundice constituted majority cases. Septicemia was the commonest cause of pathological jaundice and ABO incompatibility is second commonest cause of pathological jaundice. Pre-term and low birth weight babies were having higher levels of serum total bilirubin but the difference was not significant (P >0.05). The rise in serum bilirubin level was found to be more in pathological jaundice as compare to physiological jaundice. Difference was significant statistically with p value of <0.05.Conclusions: Most of the cases were having physiological jaundice although septicemia and ABO-Rh incompatibility were not exceptional. Peak serum bilirubin levels were found to be more among the pathological jaundice. Also, prematurity and low birth weight were having higher levels of serum bilirubin. Special care must be given to them in order to avoid future complications of hyperbilirubinemia.
7
Sari, Vista Claudia, Irwanto Irwanto, Widati Fatmaningrum, and Martono Martono. "PHYSIOLOGICAL JAUNDICE OF FIRST BREAST MILK (COLOSTRUM) IN HOSPITAL AIRLANGGA UNIVERSITY." Indonesian Midwifery and Health Sciences Journal 4, no. 1 (September 19, 2021): 60. http://dx.doi.org/10.20473/imhsj.v4i1.2020.60-72.
Full textAbstract:
ABSTRACTBackground: 60-70% of newborns have jaundice and can potentially become pathological jaundice. The effects of jaundice are often incurable, can cause disability to mental retardation. Jaundice is one of the causes of neonatal death. Jaundice accounts for 6% of neonatal deaths. Breastfeeding especially colostrum is often associated as one of the factors that can influence the occurrence of jaundice in newborns. Method: This type of research is descriptive quantitative. The population is all newborns at Airlangga University Hospital, Surabaya. The study was conducted from October to November 2019. Non-random sampling technique with total sampling. Results: There were 159 newborns in RSUA from October to November 2019. 14 newborns were not found in medical records, 10 were not given the first breast milk. Of the 135 research samples given the first ASI 18 samples or 13.33% who experienced physiological jaundice. 94.44% of the total sample of 18 who experienced physiological jaundice were babies born to mothers aged 21-35 years. 66.67% of babies with jaundice are infants with mothers as housewives. 61.11% of babies with high school graduation, 72.22% were born by cesarean section, 72.22% were born with a history of clear membranes, and 61.11% were born by primiparous mothers. Conclusion: Newborns were given first breast milk (Colostrum), 85.2% did not experience jaundice, 13.3% experienced physiological jaundice and 1.5% pathological jaundice. Jaundice can occur due to many factors; maternal, neonatal and perinatal factors.
8
Roma, K. M., Piush Kanodia, Manita Pyakurel, and Veena Gupta. "A Study of Neonatal Hyperbilirubinemia in Mid-Western Part of Nepal." Journal of Nepalgunj Medical College 15, no. 2 (June 1, 2017): 41–43. http://dx.doi.org/10.3126/jngmc.v15i2.22843.
Full textAbstract:
Introduction: Neonatal hyperbilirubinemia is a common cause of hospital admissions. Serum Bilirubin depends on birth weight and gestational age. Common causes of neonatal jaundice are physiological jaundice, breast feeding/milk jaundice, prematurity and pathological causes. Surmount total serum bilirubin over critical level, crosses the blood brain barrier leading to kernicterus. Prompt identification and proper management is of great importance otherwise there is a risk of bilirubin encephalopathy.
Objectives: To find out the prevalence and causes of neonatal jaundice in our setting and treatment modalities undertaken.
Materials and methods: A hospital based descriptive study was done among total newborns including both inborn and out born admitted in NICU, NGMC over the period of one year. A total 288 newborns with jaundice were enrolled in the study .Data were entered in excel and th analyzed in SPSS 18 version. Descriptive data were presented through pie, bar graph, and table with frequency and percentage.
Results: Prevalence of neonatal jaundice was 31%. Causes of neonatal jaundice were physiological and pathological in 56% and 44% cases respectively. Among the pathological causes ABO incompatibility was the most common cause seen in 11.4% cases followed by sepsis seen in 8.7% cases.
Conclusions: Phototherapy is very effective treatment modality to reduce the serum bilirubin in most of the cases neonatal hyperbilirubinemia and if the bilirubin crosses the cut off limit according to Bhutani's chart then we have to consider exchange transfusion. Appropriate management in time leads to satisfactory outcome.
9
Acharya, Niraj, and Chandra Prasad Paneru. "Prevalence and Etiology of Neonatal Jaundice in a Tertiary Care Hospital." Journal of Nepalgunj Medical College 18, no. 2 (August 9, 2021): 35–38. http://dx.doi.org/10.3126/jngmc.v18i2.38891.
Full textAbstract:
Introduction: Neonatal jaundice is a major clinical condition worldwide occurring in upto 60% of term and 80% preterm newborn in the first week of life. Neonatal jaundice is defined as total serum bilirubin level above 7 mg/dl.
Aims: This study was done to find out the prevalence and etiology of neonatal jaundice in neonates admitted to Neonatal Intensive Care Unit (NICU) of Nepalgunj Medical College Teaching Hospital (NGMCTH) Kohalpur, Banke.
Methods: It was a prospective cross sectional hospital based study conducted from November 2018 to November 2019 in Neonatal Intensive Care Unit of Nepalgunj Medical College Teaching Hospital. All neonates with clinical jaundice and hyperbilirubinemia with total serum bilirubin of ≥7 mg/dl were subjected to complete history taking, through physical examination and investigations.
Results: Out of 892 neonates who developed clinical jaundice, 640 neonates whose parents gave consent were included in the study. The prevalence of neonatal jaundice was found to be 39.85% with male to female ratio of 1.79:1. In the present study pathological jaundice was seen in 74.94% whereas physiological jaundice in 23.66%. Among the various etiologies of pathological jaundice, neonatal sepsis (44.52%) was found to be the most common cause followed by ABO incompatibility (12.18%) and Rh incompatibility (7.03%).
Conclusion: The prevalence of neonatal jaundice in present study was 39.85% and the most common cause was neonatal sepsis .The prevalence of jaundice was more in preterm than in term neonates. Neonatal jaundice is very common morbidity in NICU especially in preterm babies.
10
Mukhopadhyay, Sujaya, and Najia Hassan. "Etiology and clinico-hematological profile of neonates with pathological unconjugated hyperbilirubinemia: a tertiary care centre experience." International Journal of Contemporary Pediatrics 6, no. 5 (August 23, 2019): 1888. http://dx.doi.org/10.18203/2349-3291.ijcp20193656.
Full textAbstract:
Background: Jaundice is visible manifestation of raised serum bilirubin. Jaundice in newborns is not an uncommon occurrence. Usually jaundice in newborn is due to elevation of unconjugated bilirubin. There are varied causes of unconjugated hyper bilirubenemia. This study was conceptualized to see the etiology and clinico-hematological profile of neonates with pathological unconjugated hyperbilirubinemia who were admitted in the specific time frame in Sharda Hospital, Greater Noida which is a tertiary care hospital in Western U.P. Methods: This is a retrospective study in which data of all neonates admitted to NICU with unconjugated hyperbilirubinemia requiring phototherapy and/or exchange transfusion in the period 1.7.2018 to 31.12.2018 was collected and analyzed. History including birth weight, mode of delivery, gestational age, mother's blood group, etc. was recorded. Complete physical examination and investigation done for diagnosis noted. Results: It was seen that out of 438 admissions in NICU, 63% had neonatal jaundice and 18.8% of this had pathological unconjugated hyper bilirubenemia. 63.5% were males and 36.5% females. Majority were term babies. Most of the babies developed jaundice on day 3 of life. In 61% cases no cause for jaundice could be ascertained despite investigations for the same. ABO and Rh incompatibility accounted for 15.30% and 5.7% cases respectively. All patients received phototherapy and 3.8% underwent exchange transfusion. Conclusions: From the study it can be concluded that although blood group incompatibility is an important cause of pathological unconjugated hyper bilirubenemia but in most of the cases no cause is usually found.
11
He, Mingjie. "Analysis of Etiology, Diagnosis and Treatment of Neonatal Pathological Jaundice." Advanced Emergency Medicine 4, no. 1 (March 15, 2015): 11. http://dx.doi.org/10.18686/aem.v4i1.4.
Full textAbstract:
<strong>Objectives: </strong>To investigate the causes of neonatal pathological jaundice and provide the basis for clinical diagnosis and treatment. <strong>Method: </strong>The clinical data of 120 cases of neonatal jaundice were analyzed retrospectively. <strong>Results: </strong>In the cause of the disease, 22 cases of neonatal asphyxia, accounting for 21, 17.50% cases of breast feeding, accounting for 13, 10.83% cases of ABO hemolytic disease, accounting for 24.17%, 8 cases of cesarean section, accounting for 6.67%, 5 cases of premature delivery, accounting for 4.17%, 6 cases of intracranial hematoma, accounting for 5%. Infection, breast feeding, neonatal asphyxia, ABO blood group incompatibility is an independent factor. 120 cases were cured and discharged. No serious sequelae and dysfunction occurred. <strong>Conclusion: </strong>To strengthen the perinatal health care, and pay attention to the prevention and treatment of risk factors, such as infection, neonatal asphyxia, and the use of appropriate breast feeding, can effectively reduce the incidence of neonatal pathological jaundice.
12
Garg, Sandeep, Samrat Mehta, Ajay Sankhe, and Soumya Alukuchi. "Study of incidence of breastfeeding failure jaundice in cases of neonatal hyperbilirubinemia in a suburban hospital." International Journal of Contemporary Pediatrics 5, no. 6 (October 22, 2018): 2188. http://dx.doi.org/10.18203/2349-3291.ijcp20184278.
Full textAbstract:
Background: Neonatal jaundice is the most common cause of readmission after discharge from birth hospitalization. Breastfeeding failure jaundice (BFFJ) is an important subtype of pathological neonatal jaundice. It typically occurs with lactation failure during the first postnatal week that leads to insufficient intake, dehydration, weight loss and sometimes hypernatremia. Incidence of breast-feeding failure is expected to rise as the exclusive breast-feeding rates are rising. This problem is not well studied especially in Indian setting hence study was conducted.Methods: This was retrospective observational study done in Department of Pediatrics from the April 1, 2016 to March 31, 2018. 179 neonates, who presented with jaundice as main complaint with total bilirubin value above the age & risk factor matched cut off, were sampled and their clinical data was analyzed.Results: Breast feeding failure jaundice contributed 31.8% (N = 57) cases, second to the exaggerated physiological hyperbilirubinemia (48% N = 86), followed by hemolytic (13.8%, N = 25). BFFJ presented at median age of 6.8 days and had mean duration of hospital stay of 3 days. Incidences of exaggerated physiological jaundice and BFFJ were found to be higher in winter months i.e. 6.7% (N = 48/716) compared to summer months i.e. 4.1% (N = 28/679) significantly (p value = 0.045).Conclusions: Breast feeding failure jaundice (BFFJ) contributed to one third of cases of neonatal pathological jaundice requiring re-admission and is the second most common cause after exaggerated physiological jaundice. The high incidence of BFFJ in the study warrants focused efforts for a structured program of breast-feeding education, training and surveillance.
13
Pan, Xiao-Li. "Unexplained jaundice: Etiology, pathological features and diagnosis by liver biopsy." World Chinese Journal of Digestology 22, no. 27 (2014): 4156. http://dx.doi.org/10.11569/wcjd.v22.i27.4156.
Full text
14
ALVES, José Roberto, Enio Campos AMICO, Dyego Leandro Bezerra de SOUZA, Patrick Vanttinny Vieira de OLIVEIRA, and Ícaro Godeiro de Oliveira MARANHÃO. "FLUCTUATING JAUNDICE IN THE ADENOCARCINOMA OF THE AMPULLA OF VATER: a classic sign or an exception?" Arquivos de Gastroenterologia 52, no. 2 (June 2015): 147–51. http://dx.doi.org/10.1590/s0004-28032015000200014.
Full textAbstract:
Background Some authors consider the fluctuating jaundice as a classic sign of the adenocarcinoma of the ampulla of Vater. Objetive Assessing the frequency of fluctuating jaundice in their forms of its depiction in the patients with adenocarcinoma of the ampulla of Vater. Methods Observational and retrospective study, conducted through analyses of medical records from patients subjected to pancreatic cephalic resections between February 2008 and July 2013. The pathological examination of the surgical specimen was positive to adenocarcinoma of the ampulla of Vater. Concepts and differences on clinical and laboratory fluctuating jaundice were standardized. It was subdivided into type A and type B laboratory fluctuating jaundice. Results Twenty patients were selected. One of them always remained anicteric, 11 patients developed progressive jaundice, 2 of them developed clinical and laboratory fluctuating jaundice, 5 presented only laboratory fluctuating jaundice and one did not present significant variations on total serum bilirubin levels. Among the seven patients with fluctuating jaundice, two were classified as type A, one as type B and four were not classified due to lack information. Finally, progressive jaundice was the prevailing presentation form in these patients (11 cases). Conclusion This series of cases suggested that clinical fluctuating jaundice is a uncommon signal in adenocarcinoma of the ampulla of Vater.
15
Hossain, Mahmud, Momotaj Begum, Shafi Ahmed, and Md Nurul Absar. "Causes, Management and Immediate Complications of Management of Neonatal Jaundice ? A Hospital-Based Study." Journal of Enam Medical College 5, no. 2 (June 29, 2015): 104–9. http://dx.doi.org/10.3329/jemc.v5i2.23384.
Full textAbstract:
Background: Jaundice is very common in the neonatal period of life. Although it is not a major cause of mortality, it is an important cause of morbidity. So, assessment of the causes and risk factors of neonatal jaundice is very important.Objectives: The objectives of the study were to find out the causes of jaundice, its clinical features, evaluation of the outcome of current management strategy and complications encountered by the participating subjects following treatment.Materials and Methods: This prospective study was conducted in the Neonatal Unit of Rangpur Medical College Hospital (RpMCH) during July to December 2006. A total of 100 neonates having jaundice on admission or who developed jaundice following admission were included in the study. A number of investigations were done for the purpose of assessment of neonates and their icteric condition. The test statistics used to analyse the data were descriptive statistics, Chi-square (?2) and correlation tests.Results: In the present study the median age of the jaundiced newborns on admission was 5 days, while the median age of appearance of jaundice was 3.5 days. Most of the newborns exhibited jaundice 24 hours after birth and peaked by 34 days. Majority of the subjects (77%) had pathological jaundice and only 23% had physiological jaundice. This study shows septicemia was in 28% cases followed by asphyxia (20%), prematurity (18%), Rh incompatibility (15%), IUGR (11%) etc. Half of the newborns (51%) had serum bilirubin (indirect) >10 mg/dL. Gestational age and serum bilirubin was found to exhibit a negative correlation. Preterm babies also tend to develop severe to very severe jaundice more than their term counterparts (p<0.001). Birth weight was also found to bear a negative correlation with serum bilirubin. Low birth weight (LBW) babies also had a significantly higher tendency to develop severe to very severe jaundice (p<0.001). Of the 77 patients who were treated, about 64% received phototherapy, 61% received antibiotics and very few (5.2%) received exchange transfusion. Majority of the patients developed some sorts of complications. The predominant complications of phototherapy were irritability (40.8%) followed by skin rashes (26.5%), loose motion (20.4%) and dehydration (16.3%). Very few newborns (4%) had hyperthermia. All four babies who received exchange transfusion suffered from hypovolaemia, one developed hypoglycaemia and one exhibited anaemia.Conclusion: Neonatal jaundice is a leading cause of hospitalisation in the first few weeks of life throughout the world. Though management of unconjugated hyperbilirubinaemia in newborns has undergone changes based on emerging evidences, phototherapy and exchange blood transfusion are still the most commonly used effective modalities for lowering serum bilirubin level.J Enam Med Col 2015; 5(2): 104-109
16
Althomali, Ruya, Renad Aloqayli, Basma Alyafi, Ahela Nono, Suhaib Alkhalaf, Abdulaziz Aljomailan, Hesham ALHarbi, Abdulrahman Alqahtani, Hawra Alherz, and Moluk Aldebani. "Neonatal jaundice causes and management." International Journal Of Community Medicine And Public Health 5, no. 11 (October 25, 2018): 4992. http://dx.doi.org/10.18203/2394-6040.ijcmph20184604.
Full textAbstract:
80% of healthy neonates present with some degree of hyperbilirubinemia after birth, however, only 5-10% would require therapy to prevent damage or treat the cause of jaundice. Neonatal jaundice can be classified as physiological and pathological and can have several causes such as breast milk feeding, blood group incompatibility, hemolysis, or genetic defects of enzymes in the bilirubin metabolism pathway. We tried to understand the various types of neonatal jaundice, and also focus on its management. We conducted this review using a comprehensive search of MEDLINE, PubMed and EMBASE from January 2001 to March 2017. The following search terms were used: neonatal jaundice, hyperbilirubinemia, ABO incompatibility, neonatal hemolysis, kernicterus, phototherapy, exchange transfusion. Hyperbilirubinemia and jaundice are common issues encountered neonates and infants. Most cases of neonatal hyperbilirubinemia and jaundice are physiological and benign. However, some severe cases may progress to develop severe and permanent long-term complications. Therefore, early diagnosis and management is essential. Neonatal jaundice can be treated using phototherapy, pharmacological agents, intravenous immunoglobulins and exchange transfusion in severe cases.
17
Vertkin, A. L., Iu V. Sediakina, E. G. Silina, M. M. Shamuilova, E. I. Vovk, E. V. Sayutina, and S. S. Kurdjieva. "Clinical symptoms and syndromes accompanying jaundice: diagnosis bona – curatio bona." Medical alphabet, no. 7 (June 6, 2021): 24–30. http://dx.doi.org/10.33667/2078-5631-2021-7-24-30.
Full textAbstract:
Jaundice is a syndrome that occurs in the practice of doctors of all specialties, accompanies many diseases and pathological conditions. The onset of jaundice, regardless of the cause, is a formidable sign that requires immediate medical attention. Often, hyperbilirubinemia indicates the presence of a serious illness that threatens a person’s health or life. Therefore, the determination of the presence of jaundice, the assessment of its accompanying symptoms contributes to the correct diagnosis of the underlying disease, accompanied by this syndrome, the appointment of adequate therapy, which can improve the patient’s quality of life, and sometimes save life.
18
Ihara, H., Y. Aoki, T. Aoki, and M. Yoshida. "Light has a greater effect on direct bilirubin measured by the bilirubin oxidase method than by the diazo method." Clinical Chemistry 36, no. 6 (June 1, 1990): 895–97. http://dx.doi.org/10.1093/clinchem/36.6.895.
Full textAbstract:
Abstract We compared the effect of light on direct-reacting bilirubin (DBIL) measurement by the bilirubin oxidase (EC 1.3.3.5; BOX) method and by the Jendrassik-Gróf diazo method. DBIL concentrations determined by the BOX method in the sera of hyperbilirubinemic infants treated with phototherapy yielded falsely higher values than those by the direct diazo method. A similar tendency was noted when DBIL concentrations in infants' sera irradiated with light in vitro were determined by both methods, although by HPLC none of these sera had detectable DBIL (i.e., conjugated plus delta bilirubin). In general, DBIL concentrations after photoirradiation remained unchanged when measured by the diazo method, but significantly increased when the BOX method was used. Indeed, photoirradiation gave rise to material that acted like a photobilirubin product, which was oxidized at pH 3.7 and therefore was measured as DBIL. Such false increases in DBIL values generated by the BOX method may have clinical diagnostic implications in monitoring jaundiced neonates and in differentiating between physiological jaundice and incipient pathological jaundice.
19
Benga, Gheorghe, Adriana Hodârnău, Rozalia Tilinca, Victoria Borza, and William Ferdinand. "Amino acid composition of human liver mitochondrial membranes in normal and pathological conditions." Bioscience Reports 11, no. 2 (April 1, 1991): 95–100. http://dx.doi.org/10.1007/bf01119196.
Full textAbstract:
The amino acid composition of proteins from liver mitochondrial membranes has been studied in patients with normal liver, with biliary diseases and fatty liver, with obstructive jaundice or liver cirrhosis. A characteristic pattern of the amino acid composition in patients with normal liver has been found. In the mitochondrial membranes of patients with fatty liver tryptophan and lysine were decreased while [aspartic acid plus asparagine] and [glutamic acid plus glutamine] were increased compared to their counterpart in the normal liver. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in methionine content was found, while in the case of liver cirrhosis amino acid composition was markedly changed.
20
Benga, Gheorghe, and William Ferdinand. "Amino acid composition of rat and human liver microsomes in normal and pathological conditions." Bioscience Reports 15, no. 2 (April 1, 1995): 111–16. http://dx.doi.org/10.1007/bf01200145.
Full textAbstract:
The amino acid composition of proteins from liver microsomes has been studied in rats and in human subjects with normal liver, with obstructive jaundice or liver cirrhosis. The pattern of the amino acid composition of microsomes appeared to be species-specific. Phenylalanine, threonine, serine, proline, histidine and [aspartic acid plus asparagine] were increased, while alanine, tyrosine, glycine and arginine were decreased in the human compared to the rat microsomes. In patients with obstructive jaundice of short duration (less than two months) only a slight decrease in leucine and phenylalanine could be noticed, while in the case of liver cirrhosis amino acid composition was markedly changed.
21
Said, Norimah. "Postnatal mother: Knowledge and attitude towards Neonatal Jaundice (NNJ)." Elevate The International Journal of Nursing Education, Practice and Research 1, no. 1 (July 24, 2018): 40–45. http://dx.doi.org/10.25077/elevate.1.1.40-45.2018.
Full textAbstract:
ABSTRACT: Neonatal jaundice (NNJ) is a pathological situation where an imbalance between bilirubin production and excretion is present due to a multitude of factors. The objective of this study is to identify the number of post-natal mothers who had received education and their attitude on neonatal jaundice. A cross-sectional design was carried out among 131 posts natal mother. The questionnaire was given to the respondents. Results show there is a significant relationship between knowledge and attitude towards neonatal jaundice among postnatal mother. A part 50% of the mothers have a neutral attitude, 27.5% have a positive attitude and 8.4% have a negative attitude towards neonatal jaundice. The outcome of this study showed that most of them others have good knowledge on neonatal jaundice. However, they may fear invasive procedures such as taking blood from their baby. Future studies should focus on attitude towards traditional treatments among postnatal mothers.
22
Yin, X., G. Yan, J. Peng, and L. Liang. "The clinical values of methylation status of P16 and APC genes in bile in diagnosis of malignant obstructive jaundice." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 171. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.171.
Full textAbstract:
171 Background: Preoperative definitive diagnosis of malignant obstructive jaundice caused by biliary and pancreatic carcinomas still remains a major challenge. Hypermethylation of tumor suppressor genes have been implied in carcinogenesis of biliary and pancreatic malignancies. The diagnostic values of methylation status of tumor suppressor genes in bile in malignant obstructive jaundice have not been well-documented. Methods: Bile was prospectively collected from 70 patients with obstructive jaundice treated at our hospital between November 2008 and Sepetember 2009. Forty-eight of them were proved to be malignant obstructive jaundice (biliary carcinoma in 36, pancreatic carcinoma in 8 and duodenal carcinoma in 4) by pathological examination, and 22 were benign obstructive jaundice caused by cholelithiasis. DNA was extracted from bile and modified by sodium bisulfite. Methylation-specific PCR was run to detect methylation status of P16 and APC gene promoters. Their diagnostic values in malignant obstructive jaundice were assessed. Results: Hypermethylation of P16 promoter was presented in 72.9% (35/48) malignant obstructive jaundice, and 9% (2/22) bengin obstructive jaundice (p<0.05). Hypermethylation of APC promoter was presented in 56.2% (27/48) malignant obstructive jaundice, and 9% (2/22) bengin obstructive jaundice (p<0.05). With respect to their diagnostic values in malignant obstructive jaundice, sensitivity, specificity, positive predictivity and negative predictivity were 72.9%, 90.9%, 94.6% and 60.6%, respectively, for P16 gene; 56.2%, 90.9%, 93.1%, 48.8%, respectively, for APC gene. Conclusions: Methylation status of P16 and APC gene promoters in bile was valuable in diagnosis of malignant obstructive jaundice, with an excellent specificity. P16 gene had a higher sensitivity than APC gene. No significant financial relationships to disclose.
23
El-Diasty, Mohamed Tarek, Mohammad Abdelrahim Wazzan, and Ahmed Haitham Abduljabbar. "Inflammatory Myofibroblastic Tumor of the Porta Hepatis: A Case Report." Journal of Clinical Imaging Science 11 (May 22, 2021): 28. http://dx.doi.org/10.25259/jcis_91_2021.
Full textAbstract:
A 43-year-old man presented with painless jaundice. Imaging revealed a porta hepatis mass compressing the common bile duct. Endoscopic biopsy was negative for malignancy. Complete surgical resection was performed. Pathological assessment showed IGg4 negative inflammatory myofibroblastic tumor.
24
Balgimbaeva, Aizhan, Gulnar Schabdarbaeva, Assem Ibazhanova, and Zhuldyzay Kenzhebekova. "THE PATHOLOGICAL MORPHOLOGY OF PIROPLASMOSIS IN CATTLE." CBU International Conference Proceedings 3 (September 19, 2015): 427–31. http://dx.doi.org/10.12955/cbup.v3.633.
Full textAbstract:
Piroplasmosis in cows manifests mainly as a violation of erythrocytes, degenerative changes in parenchymal organs, general jaundice, hemosiderosis, and splenic hyperplasia. First, it affects the liver, followed by a violation of the digestive system; then, kidney function is impaired resulting in a breach of toxic substance released from the body. The blood is depleted in the number of erythrocytes, leukocytes, and hemoglobin. From decaying under the influence of parasite, hemoglobin is released from the red blood cells and is partially excreted by the kidneys in urine, resulting in the urine becoming dark red in color (hence, the disease is colloquially called “blood urine”). Hemoglobin part is processed into bile pigments; however, visible mucous membranes (eyes and mouth), skin, and subcutaneous tissue become yellowish.
25
Lal, Mohan, and Prabhu Dayal. "Liver function trends after biliary decompression in obstructive jaundice: a clinico-pathological-biochemical study." International Surgery Journal 7, no. 1 (December 26, 2019): 168. http://dx.doi.org/10.18203/2349-2902.isj20195964.
Full textAbstract:
Background: Liver functions tests suggest the underlying cause, estimate the severity, assess prognosis and monitor efficacy of therapy. Severity of liver dysfunction when performed serially may predict prognosis and may be helpful in assessing response to medical therapy or a surgical intervention.Methods: The data was collected in thirty cases of surgical obstructive jaundice in terms of age, sex, etiology, clinical presentation, surgical intervention for biliary drainage and the laboratory liver biochemical and coagulation profiles on a day prior to surgical intervention and post-operatively on 1st week and 4th week were recorded.Results: Of total 30 patients 56.66% were females. Patients with 73.68% of benign disease and 100% of malignant disease were of age more than 40 years. 63.33% of patients had benign cause for biliary obstruction. Choledochoithiasis and periampullary carcinoma were two most common causes of obstructive jaundice. The commonest complaints were; yellowish discolouration of sclera and skin, high colored urine (100%) and acholic stool (70%). Hepatomegaly, palpable gallbladder and ascites were observed in only malignant conditions. Serum bilirubin and transaminases were significantly higher in patients with malignant lesions on pre-operative and postoperative assessment. After decompression the rate of fall of serum bilirubin, serum glutamic-oxaloacetic transaminase and SGPT were almost identical in both benign and malignant biliary obstructions. However, a better biochemical recovery profile was observed in patients with benign lesions, as they returned to normal by 4 weeks but remained at 2 to 3 times of the normal in malignant lesions.Conclusions: Sequential biochemical assessment of liver functions has diagnostic as well as prognostic value in surgical obstructive jaundice.
26
Agrawal, Vijay, Alok Kumar Goyal, J. N. Sharma, and Murli D. Yadav. "Different causes of prolonged unconjugated Jaundice in the newborns." International Journal of Contemporary Pediatrics 4, no. 3 (April 25, 2017): 984. http://dx.doi.org/10.18203/2349-3291.ijcp20171712.
Full textAbstract:
Background: Prolonged unconjugated hyperbilirubinemia is a type of neonatal jaundice, which occurs in infants with high bilirubin levels (>10 mg/dl) persisting beyond 14-21 days. Prolonged unconjugated hyperbilirubinemia is a common problem among newborns, and the prevalence rate has been estimated at 2-15%. According to the literature, breastfeeding is a major cause of prolonged jaundice, and about 40% of infants who are exclusively breastfed are diagnosed with this disorder. Among other pathological causes associated with prolonged hyperbilirubinemia are urinary tract infection (UTI), congenital hypothyroidism and hemolysis. So, this study was done to know the different causes of unconjugated jaundice in newborn.Methods: This Hospital based prospective descriptive study was carried out at outpatients and inpatients in the Department of pediatrics, SMS medical college Jaipur. Total 100 cases were taken and these neonates were evaluated to know different causes of unconjugated hyperbilirubenemia.Results: Most common cause of persistent jaundice in both term and preterm babies is breast milk jaundice (66%), other causes include isoimmunization (10%), cephalhematoma (7%), hypothyroidism (7%), sepsis (4%) and ABO incompatibility (3%). Etiology of persistent jaundice was not significantly different in term and preterm babies.Conclusions: Although breast milk jaundice is considered as a major cause of prolonged unconjugated hyperbilirubinemia in neonates, identification of other etiological factors, such as UTI, congenital hypothyroidism and hemolysis is also of paramount importance. Early diagnosis and treatment of these disorder could effectively prevent further complication in neonates.
27
Ling, Zhang, Zhang Xiping, Qiu Fengmei, Yan Ping, and Cheng Qihui. "Protective Effects ofSalvia miltiorrhizaeon Multiple Organs of Rats with Obstructive Jaundice." Mediators of Inflammation 2009 (2009): 1–9. http://dx.doi.org/10.1155/2009/602935.
Full textAbstract:
Purpose. we aim to explore the protective effects ofSalvia miltiorrhizaeinjection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin,PLA2, and TNF-αin the blood.Methods. A total of 90 mice were randomly divided into sham-operated group, model-control group, andSalvia miltiorrhizae-treated group (n=30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d,n=15) and 28 d subgroup (consecutive administration for 28 d,n=15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin,PLA2, and TNF-αin the blood were determined.Results. Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasmaPLA2content in treated group was significantly lower than that in model-control group.Conclusion.Salvia miltiorrhizaeinjection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.
28
Anggraini, Dina Dewi, and Martha Kahi Juwa. "Relationship Between the Weight of a Low Birth Agency With Justice in The Hospital Bhayangkara Kediri City." Journal of Midwifery Science: Basic and Applied Research 2, no. 1 (July 13, 2020): 18–21. http://dx.doi.org/10.31983/jomisbar.v2i1.5932.
Full textAbstract:
Jaundice is a yellow stain on the skin, sclera, or mucous membranes as a result of excessive accumulation of bilirubin in the tissues. Low birth weight babies (LBW) are defined as birth weight 2,500 grams or less. In infants with low birth weight can experience various complications, one of which is hyperbilirubinemia (jaundice). This study aims to determine the relationship of Low Birth Weight Babies (LBW) with the incidence of jaundice in Bhayangkara Hospital in the city of Kediri. The research design used is correlational analytic research. The method used is a cross sectional approach. The sampling technique was carried out in total sampling as many as 105 samples of infants with LBW. Research data is taken from medical records. Data were analyzed univariately and bivariately using Spearman's Rho test. The results of the study showed that out of 105 infants with low birth weight who experienced physiological jaundice as many as 75 infants (71.4%) and pathological jaundice as many as 30 infants (28.6%). The results of the Spearman Rh Rho test analysis showed that the p value = 0.067 or less than α = 0.05 (0.067 0.05), which means that H0 is rejected and H1 is accepted, meaning that there is a relationship between the incidence of LBW and neonatal jaundice in Bhayangkara Hospital in the City Kediri in 2018. The strength of the relationship is based on the correlation coefficient of 0.196 which means that there is a moderate relationship between the incidence of LBW and jaundice in Bhayangkara Hospital in Kota Kadiri in 2018.
29
Muliawati, Ni Kadek, I. Gusti Ayu Trisna Windiani, Anak Agung Sagung Sawitri, and Luh Seri Ani. "Time of colostrum discharge of more than six hours as a risk factor for physiological jaundice in neonates." Public Health and Preventive Medicine Archive 7, no. 1 (July 31, 2019): 44. http://dx.doi.org/10.15562/phpma.v7i1.193.
Full textAbstract:
Background and purpose: Neonatal jaundice is both a physiological and pathological condition. Neonatal physiological jaundice occurs within 3-5 days after the baby is born. Publications about colostrum and neonatal jaundice are still limited. This study aims to determine the risk of the onset of colostrum discharge of more than 6 hours to physiological jaundice in neonates.Methods: A case control study was conducted at the Sanglah General Hospital in Denpasar from August to December 2017. The number of cases was 55 neonates with physiological jaundice and the number of controls was 55 neonates without physiological jaundice. Cases and controls were selected by consecutive sampling. The occurrence of physiological jaundice was obtained by direct observation and the degree of jaundice was determined based on the division of Kramer's body zone. Neonates with the Kramer grades I and II at the age of 3-5 days were classified as experiencing physiological jaundice (as cases) and neonates with a Kramer grade of 0 at the age of 3-5 days were classified as not jaundice (as controls). Cases were matched with controls by sex and age of the neonates. Data on maternal socio-demographic characteristics, onset of colostrum discharge, early breastfeeding initiation and 24-hour breastfeeding frequency were obtained by interview; data on jaundice was obtained by observation while mode of delivery, parity, history of pre-eclampsia, prematurity, neonatal birth weight, history of birth trauma (cephalic hematoma), history of asphyxia and major congenital abnormalities were obtained from medical records. Multivariate analysis with binary logistic regression was carried out to determine the adjusted odds ratio (AOR) of the onset of colostrum discharge.Results: The characteristics of cases and controls were found to be similar in terms of maternal education, neonatal age and sex, parity and pre-eclampsia history. Significant outset of colostrum >6 hours was found to be associated with physiological jaundice with AOR=2.57 (95%CI: 1.04-6.37). In this study, variables that were not found to be the risk factors of physiological jaundice in neonates were: cesarean delivery (AOR=0.36; 95%CI: 0.09-1.41; p=0.14), breastfeeding frequency within 24 hours (AOR=2.20; 95%CI: 0.47-10.23; p=0.31) and early breastfeeding initiation (AOR=0.71; 95%CI: 0.19-2.59; p=0.60)Conclusion: Onset of colostrum discharge >6 hours is a risk factor for neonatal jaundice. Efforts should be made to accelerate the release of colostrum in order to prevent neonatal jaundice.
30
Goel, Keshawati, and Anshuman Srivastava. "Study of clinical spectrum of hyperbilirubinemia with frequency of glucose six phosphate dehydrogenase deficiency in neonates." International Journal of Research in Medical Sciences 9, no. 6 (May 27, 2021): 1674. http://dx.doi.org/10.18203/2320-6012.ijrms20212235.
Full textAbstract:
Background: Jaundice is defined as visible reflexion of serum hyperbilirubinemia on mucous membranes and skin as yellowish discoloration. The frequency of icterus among neonates is about 1 in 2500-5000 live births. When there is disparity between the production of bilirubin, conversion from unconjugated to conjugated bilirubin and excretion of bilirubin results in jaundice. Unconjugated bilirubin is usually harmless but it can also cross blood-brain barrier causing neurotoxicity or kernicterus.Methods: A hospital based prospective observational study which is carried out in the department of paediatrics of Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh from December 2019 to November 2020 on 74 neonates who required admission for hyperbilirubinemia.Results: The most common jaundice occurred in neonates were idiopathic or breastfeeding jaundice as the neonates were breast fed (47.29%). The second most common cause was ABO incompatibility leading to jaundice in 27 (36.48%) neonates. Incidence of neonatal Sepsis, G6PD deficiency, hypothyroidism and cephalhematoma was 22.9%, 4.1%, 2.70% and 4.1% respectively. Polycythemia contributed to 1.35% and the frequency of hyperbilirubinemia in infants of diabetic mother’s or GDM was 10.8%. Rh incompatibility was seen in 13.5%.Conclusions: G6PD deficiency is a significant cause for NNHB and the cases with pathological jaundice if left untreated may lead to severe neurological deficits and lifelong disabilities, hearing impairment, mental retardation, seizures and movement disorders. Hence we recommend G6PD screening in every newborn with significant hyperbilirubinemia to reduce morbidity and mortality.
31
Tibana, Tiago Kojun, Renata Motta Grubert, Vinicius Adami Vayego Fornazari, Fábio Colagrossi Paes Barbosa, Bernardo Bacelar, Amauri Ferreira Oliveira, Edson Marchiori, and Thiago Franchi Nunes. "The role of percutaneous transhepatic biliary biopsy in the diagnosis of patients with obstructive jaundice: an initial experience." Radiologia Brasileira 52, no. 4 (August 2019): 222–28. http://dx.doi.org/10.1590/0100-3984.2018.0073.
Full textAbstract:
Abstract Objective: To evaluate the accuracy of percutaneous transhepatic biliary biopsy (PTBB) in patients with suspected biliary obstruction. Materials and methods: This was a retrospective analysis of 18 patients with obstructive jaundice who underwent PTBB. In each patient, three to ten fragments were collected from the lesion. The final diagnosis was confirmed in the pathology report. We also reviewed analyses of the results of laboratory tests performed before the procedure, as well as the Bismuth classification, clinical outcome, complications occurring during the procedure, access route, and materials used. Results: Technical success was achieved in 100% of the PTBB procedures. Among the 18 patients clinically diagnosed with bile duct stenosis, the pathological analysis confirmed that diagnosis in 17. In one case, the pathological findings were considered false-negative. The predominant tumor was cholangiocarcinoma (seen in 50% of the cases). Sixteen of the procedures (88.9%) were performed without complications. Transient hemobilia occurred in one case, and cholangitis occurred in another. Conclusion: PTBB is a safe, viable, simple technique with a high rate of true-positive results for the definitive diagnosis of obstructive jaundice.
32
Predescu, Alexandru, Sorina Diaconu, Nicoleta Tiuca, Adina Purcareanu, Alina Tomescu, Denisa Cuciureanu, Filip Petruta, Palan Ana Maria, Calota Carmen, and Corina Pop. "Leptospirosis - A Case Report." Internal Medicine 15, no. 4 (August 1, 2018): 45–53. http://dx.doi.org/10.2478/inmed-2018-0029.
Full textAbstract:
AbstractLeptospirosis is a spirochaetal zoonosis, with a broad spectrum of clinical manifestations, ranging from mild (febrile illness) to fulminant forms (systemic disease with jaundice and kidney failure – Weil's disease).We present the case of a 62 year old patient, with no personal pathological incidents, brought to the emergency room for fever, chills, myalgia, nausea, vomiting, abdominal pain, for 14 days, with jaundice, shortness of breath, and confusion for 72 hours. Clinical examination revealed fever, confusion, jaundice, tachypnoea, tachycardia, irregular heart rhythm, hypotension, anuria, hepatomegaly, no clinical signs of liver cirrhosis or flapping tremor. Laboratory tests revealed leucocytosis with neutrophilia, hepatic cytolysis, renal failure, rhabdomyolysis, while the imagistic investigations were normal. Serological tests were performed for viral, drug induced hepatitis, autoimmune diseases, other infectious diseases (Elisa and ultramicroscopic agglutination tests were positive for leptospirosis). Later, the patient's condition worsened, resulting in intubation and mechanical ventilation, persistence of febrile syndrome and jaundice, bilateral lower limb petechiae with hepatic encephalopathy. Broad spectrum antibiotics (Ceftriaxone and Penicillin G), dialysis, hydroelectrolytic rebalancing, Dopamine support, antiarrhythmic drugs were administered, and the hepatic encephalopathy was also treated. The outcome was favourable (extubation, resolution of febrile syndrome, inflammation, jaundice and hepatic encephalopathy).This case is an example of atypical, monophasic leptospirosis which is common in Weil's disease (the most severe form of leptospirosis), with onset as a febrile illness leading to multiple system organ failure.
33
., Karthikeyan Panneerselvam, Sathyamoorthy Mani ., Balaji Ramraj ., Sekar Pasupathy ., Muthulakshmi Munusamy ., and Subash Sundar . "PREDICTING PATHOLOGICAL JAUNDICE IN TERM BABIES WITH ABO SETTING USING CORD BLOOD BILIRUBIN." Indian Journal of Child Health 5, no. 11 (November 30, 2018): 686–88. http://dx.doi.org/10.32677/ijch.2018.v05.i11.009.
Full text
34
Bohra, Jasraj, and Chuba Kumzuk L. C. R. "Etiological study of jaundice in neonates." International Journal of Contemporary Pediatrics 6, no. 5 (August 23, 2019): 1881. http://dx.doi.org/10.18203/2349-3291.ijcp20193600.
Full textAbstract:
: Jaundice is the commonest abnormal finding with an incidence of about 60% in term babies and 80% in preterm babies. It is the commonest cause of admission to hospitals in the newborn period. In preterm babies, the percentage is exceedingly high due to their physiological handicaps and other hazards of prematurity like Asphyxia, septicemia, respiratory and circulatory Insufficiency. Non-physiological or pathological jaundice is also known to occur in (8-9)% of newborns. Its timely detection and optimal management are crucial to prevent brain damage and subsequent neuro-motor retardation. Aims of this study to find out the etiology of jaundice in neonates, admitted in neonates unit attached to SMS medical college Jaipur.Method: This Observational study was conducted in Neonatal Intensive Care Unit (NICU) and Post Natal Ward attached to SMS medical college Jaipur, after approval from the hospital ethical committee, over a period of 12 months(October 2011 to September 2012. Study was carried on 500 neonates presenting clinically with neonatal hyperbilirubinemia.Result: The onset of jaundice was seen maximum between live hour 24-72 hours (n=290, 58% cases), followed by live hour 72 hours-14 days (n=160, 32%). At more than 2 weeks there was only 3 case (0.6%). The etiological factors in the causation of jaundice in the decreasing order of frequency were exaggerated physiological jaundice accounts for (28%), ABO-incompatibility (24.4%), Rh-incompatibility (13.8%), Idiopathic (10.4%), cephalhematoma (10.2%), septicemia (6%), intrauterine infections (4%), BMJ (1.8%), Galactocemia (0.8%) and G6PD Deficiency (0.6%) respectively.Conclusion: Hyperbilirubinemia is more severe in newborns, therefore precautionary measure should be adopted by both parents, and clinicians to diagnose and treat the diseases properly.
35
Darenskaya, M. A., O. V. Smirnova, B. G. Gubanov, E. V. Kasparov, L. A. Grebenkina, L. I. Kolesnikova, and S. I. Kolesnikov. "Analysis of neutrophils functional activity in men with mechanical jaundice of various genesis." Russian Clinical Laboratory Diagnostics 65, no. 9 (September 16, 2020): 547–51. http://dx.doi.org/10.18821/0869-2084-2020-65-9-547-551.
Full textAbstract:
Obstructive jaundice (OJ) or blockage of the bile duct code K83.1 (according to ICD 10), occurs in approximately 45-50% of cases of all varieties of jaundice, it can be both non-tumor and tumor genesis. The functional pathway plays a special role in the genesis of complications of breast the activity of neutrophils as key effector cells responsible for the development of the inflammatory process in the breast. Investigation of the metabolic mechanisms of the functioning of neutrophils allows us to identify intracellular targets, when exposed to It was possible to modulate the level of cell reactivity.The study used data from 47 men with obstructive jaundice of non-tumor origin and 45 men with obstructive jaundice of tumor origin (stage I-II of the tumor process). As a control, data from 100 practically healthy men were used. A pronounced change in the kinetics of the chemiluminescent response of neutrophils in men with obstructive jaundice was found, consisting in an increase in the time to reach the maximum intensity, maximum intensity, area under the curve and activation index for both spontaneous and luminol-dependent induced chemiluminescence. The development of the tumor process in this category of patients was accompanied by a decrease in the area parameter under the curve during spontaneous and induced reactions, time to maximum, intensity maximum and activation index during spontaneous chemiluminescence. The data obtained indicate a marked increase in the values of the functional activity of neutrophils in patients with obstructive jaundice of benign origin, as well as a sharp decrease in their values in the presence of a pathological process of malignant origin.
36
And E. H. Al- Taee, R. A. S. AL Naimi, O. H. Khalaf, S. Y. Tano. "Pathological study of Hepatic coccidiosis in naturally infected rabbits." Al-Qadisiyah Journal of Veterinary Medicine Sciences 11, no. 1 (June 28, 2012): 63. http://dx.doi.org/10.29079/vol11iss1art172.
Full textAbstract:
Thirty young domesticated rabbits (age 2-2.5 mo) of sexes showed clinical signs of anorexia, debilitation, diarrhea, icterus, rough hair coat and pendulous abdomen with hepatomegaly. Fecal samples were collected for demonstrated the presence of oocysts. Postmortem examination revealed the presence of discrete yellowish-white nodules of 1mm to 2 cm size on the surface and throughout the parenchyma containing a thick creamy white fluid. The histopathological changes showed biliary hyperplasia with different developmental stages of Eimeria stiedae in the epithelial cells, cholangitis and peribiliary fibrosis with newly formed bile ductules, severe congestion, and dilation of central veins and sinusoids with disruption hemorrhagic areas. The hepatocytes showed degenerative changes to necrosis with areas of fibrosis and mononuclear cell aggregation, obstructive jaundice and a tendency to form oocyst granuloma. In conclusion hepatic coccidiosis lead to severe pathological changes both in bile ducts and liver parenchyma especially in young animals.
37
Xiping, Zhang, Zhang Jie, Ye Shuyun, Wang Qili, Feng Guanghua, and Pan Yan. "Influence ofSalvia miltiorrhizaeon the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice." Mediators of Inflammation 2009 (2009): 1–7. http://dx.doi.org/10.1155/2009/675195.
Full textAbstract:
Objective. To observe the effect ofsalvia miltiorrhizaeinjection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism ofsalvia miltiorrhizaeon the lymph nodes of these rats.Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P<.05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.Conclusion.Salvia miltiorrhizaecan exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.
38
Kafle, Shyam Prasad, Mukesh Bhatta, Ramesh Shrestha, Sarita Sitaula, Namu Koirala, and Anupam Koirala. "Outcome of Neonatal Hyperbilirubinemia from a Tertiary Care Hospital in Eastern Nepal: A Cross-sectional Study." Journal of BP Koirala Institute of Health Sciences 4, no. 1 (June 30, 2021): 37–42. http://dx.doi.org/10.3126/jbpkihs.v4i1.36324.
Full textAbstract:
Background: Timely detection and treatment of pathological hyperbilirubinemia in newbornscan prevent acute bilirubin encephalopathy and its consequences. We aimed to identifyitsoccurrence, presentationtime, phototherapyduration, need for exchange transfusion,and outcome.
Methods: In this cross-sectional study, we enrolled all the babies admitted for pathological neonatal hyperbilirubinemia in the university hospital ofBPKIHSin a one-yearduration. Babies with life-threatening congenital malformations or conjugated bilirubin >20% of total serum bilirubin or >2 mg/dl were excluded. Obstetric profile of mothers, clinical and laboratory parameters of babies, onset time of pathological jaundice, duration of phototherapy, need for exchange transfusion or intravenous immunoglobulin were recorded. Neonatal outcome was classified as good and poor and its association with potential predictors analyzed.
Results: One-hundred and fifty babiesdeveloped neonatal jaundice requiring treatment. The most common causes includedABO and Rh setting. No cause was found in 26 (18%) babies. One-hundred and eight babies (72%) were only managed withphototherapy whereas 42 (28%) required both phototherapy and double volume exchange therapy. The majority (84.5%) had good outcome without any residual neurological deficit at discharge.Babies with total serum bilirubin >20 mg/dl at presentation, duration of phototherapy >44.8 h, ABO setting, hemolysis, and out born statussignificantly developed poor outcome (p < 0.05).
Conclusion: About 15% of the babies with hyperbilirubinemia had acute bilirubin encephalopathy at discharge suggestive of poor outcome. Babies with high bilirubin at presentation, longer duration of phototherapy, ABO settings, hemolysis, and out born statusdeveloped poor outcome.
39
Thomas, Mercy, Winita Hardikar, Ronda F. Greaves, David G. Tingay, Tze Ping Loh, Vera Ignjatovic, Fiona Newall, and Anushi E. Rajapaksa. "Mechanism of bilirubin elimination in urine: insights and prospects for neonatal jaundice." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 6 (January 15, 2021): 1025–33. http://dx.doi.org/10.1515/cclm-2020-1759.
Full textAbstract:
Abstract Despite a century of research, bilirubin metabolism and the transport mechanisms responsible for homeostasis of bilirubin in serum remain controversial. Emerging evidence on the hepatic membrane transporters and inherited disorders of bilirubin metabolism have contributed to a greater understanding of the various steps involved in bilirubin homeostasis and its associated excretory pathways. We discuss these recent research findings on hepatic membrane transporters and evaluate their significance on the newborn bilirubin metabolism and excretion. New insights gained speculate that a proportion of conjugated bilirubin is excreted via the renal system, as an alternative to the intestinal excretion, even in normal physiological jaundice with no associated pathological concerns. Finally, this paper discusses the clinical relevance of targeting the altered renal excretory pathway, as bilirubin in urine may hold diagnostic importance in screening for neonatal jaundice.
40
Nasu, Y., S. Kondo, S. Hirano, E. Tanaka, T. Tsuchikawa, J. Matsumoto, and K. Kato. "Evaluation of obstructive jaundice as a poor prognostic factor after curative resection of advanced gallbladder cancer." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 340. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.340.
Full textAbstract:
340 Background: Gallbladder cancer (GBC) is one of the most common malignancies of the biliary tract. Because of the lack of specific presentations, this condition is frequently diagnosed only at an advanced stage. Obstructive jaundice is generally regarded as an indicator of far advanced disease, unresectability, and poor prognosis. The aim of this study was to evaluate clinicopathological factors, especially jaundice, influencing outcome after radical resection of gallbladder cancer, in order to identify the patients benefiting from radical surgery. Methods: Seventy-five patients with GBC underwent surgical resection between 1998 and 2008. A retrospective analysis was conducted on sixty-four patients with UICC T2 or more tumors. Clinicopathologic features, extents of resection, and survival rates were investigated retrospectively. Obstructive jaundice was defined that serum T-bil level was more than 2.0 mg/ml. Patients with jaundice underwent ENBD or PTBD and curative resection was performed when serum T-Bil level decreased below 2.0 mg/ml. Right after laparotomy, para-aortic lymphadenectomy and frozen section pathology were performed to convert a radical resection to a palliative procedure when a para-aortic lymph node was positive. Results: The three and five-year disease-specific survival rates were 47% and 41%, respectively. Nine patients survived for more than five years.Univariate analysis showed that blood loss during operation, hepatic invasion, portal vein invasion, N category, M category after postoperative pathological examination and residual tumor were significant prognostic factors (p<0.05), but multivariate analysis showed that M category only was independent prognostic factor (p<0.05). Five-year disease-specific survival rates for patients with (n=37) and without (n=27) obstructive jaundice were 47% and 35%, respectively (p=0.69). Conclusions: Obstructive jaundice had no impact on postoperative survival as long as metastatic disease was exclueded and adequate resection of the hepatic hilum was performed. Aggressive surgery might bring long-term survival in selected patients even with obstructive jaundice by advanced gallbladder cancer. No significant financial relationships to disclose.
41
Pashankar, Dinesh, and Richard A. Schreiber. "Neonatal Cholestasis: A Red Alert for the Jaundiced Newborn." Canadian Journal of Gastroenterology 14, suppl d (2000): 67D—72D. http://dx.doi.org/10.1155/2000/657368.
Full textAbstract:
Neonatal jaundice may indicate cholestasis rather than a benign, physiological condition. Any four-week-old newborn with persistent jaundice should have a fractionated bilirubin screen to determine whether the hyperbilirubinemia is unconjugated. Conjugated hyperbilirubinemia, a hallmark of neonatal cholestasis, is pathological and requires further investigation. These infants need prompt diagnosis, early intervention and careful follow-up to ensure continued growth and development. Recent progress in the physiology of bile flow is reviewed, and the evaluation and management of neonatal cholestasis are summarized. Further advances in delineating the cellular and molecular processes that regulate bile acid metabolism in both health and disease will lead to a greater understanding of the conditions causing neonatal cholestasis. Unravelling the etiopathogenesis of these neonatal cholestatic disorders will allow the development of novel diagnostic and therapeutic interventions that ultimately will effectuate the prognosis for these young patients.
42
Yu, Zhongxin. "Solid Pseudopapillary Neoplasm of the Pancreas: Clinical-Radiological-Pathological Characteristics of Four Pediatric Cases." Gastroenterology Pancreatology and Hepatobilary Disorders 04, no. 01 (July 10, 2020): 01–07. http://dx.doi.org/10.31579/2641-5194/011.
Full textAbstract:
Solid Pseudopapillary Neoplasm (SPN) of the pancreas represents 1-3 % of all exocrine pancreatic tumors and is uncommon in children. We report four pediatric patients with SPN where each patient posed a unique diagnostic and therapeutic challenge. We describe these four cases with detailed clinical-radiological-pathological correlations. All patients are female, with a median age 13.5 years. Two patients presented with abdominal pain, one with jaundice and one with an incidental pancreatic mass on abdominal CT scan. Radiological studies included abdominal ultrasound, CT scan and MRI of abdomen. Pancreaticoduodenectomy was performed in three patients and laparoscopic distal pancreatectomy in one patient. Mean tumor size was 4.5 cm (ranged from 1.9 to 11.5 cm). All SPNs were benign on histological exam. One patient developed pancreatic insufficiency post-surgery. No tumor recurrence was observed over a mean follow up period of 1 year. We conclude that diagnosis of SPN in pediatric population can be challenging due to non-specific clinical findings, and surgical removal of the tumor is usually required for definitive histologic diagnosis and treatment. Most tumors are benign and recurrence is very rare.
43
Patel, Apexa S., Deepak A. Desai, and Aneri R. Patel. "Association of ABO and Rh incompatibility with neonatal hyperbilirubinaemia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 4 (March 30, 2017): 1368. http://dx.doi.org/10.18203/2320-1770.ijrcog20171393.
Full textAbstract:
Background: 60% of term new-born have clinical jaundice, in the first week of life. ABO incompatibility is the most common cause of haemolytic disease of the new-born. So early intervention, at proper time, is mandatory to prevent these sequelae.Methods: This study was done at Dhiraj Hospital in Obstetrics and Gynecology Department. It was prospective observational study. 200 new-born with ABO incompatibility and 20 new-born with Rh incompatibility, causing clinically significant neonatal hyperbilirubinemia, were recruited for the clinical study noted.Results: The incidence of ABO incompatibility in our study was 13.79% and of Rh incompatibility was 1.37%. In ABO incompatibility group, 90% new born developed clinical jaundice. In treated group, out of 88 new born, 82 were from O-A and O-B incompatibility group. In ABO incompatibility DCT was positive in only 9%, whereas in Rh incompatibility it was 25%. In ABO incompatibility group, majority, 56% did not require treatment, whereas in Rh incompatibility group 65% required treatment. In ABO incompatibility group only 1% required exchange transfusion whereas in Rh incompatibility, it was required in 10%. In ABO incompatibility, all new-born treated well except, 0.5% developed kernicterus. In Rh incompatibility group, 10% new-born developed kernicterusConclusions: In ABO incompatibility, if jaundice develops, it remains in physiological limits. In presence of some aggravating conditions may present as pathological jaundice. It results in significant morbidity but no mortality. So prevention of aggravating factors is very important, in case of ABO incompatibility.
44
Pradhan, Ashish, Rachna Lamichaney, and Vibhu Sharma. "Cord blood bilirubin level as a predictor of development of pathological hyperbilirubinemia in new-borns." International Journal of Contemporary Pediatrics 4, no. 4 (June 21, 2017): 1519. http://dx.doi.org/10.18203/2349-3291.ijcp20172698.
Full textAbstract:
Background: There may be a delay in recognition of pathological hyperbilirubinemia which may lead to serious consequences in the new born. The purpose of this study was to verify whether the cord bilirubin levels predicted the development of pathological hyperbilirubinemia.Methods: In this hospital based prospective cross-sectional study conducted at Central Referral Hospital, Gangtok from December 2014 to November 2015, 202 live new born meeting the inclusion criteria were enrolled. After birth, cord blood was collected for the estimation of cord blood bilirubin and the babies were followed up daily for the development of clinical jaundice. Peripheral venous blood was collected for the estimation of serum bilirubin levels in those who developed clinical jaundice.Results: The incidence of pathological hyperbilirubinemia in our study is 12.87%. The mean gestational age is 38.3 weeks. There is a significant association between cord blood total bilirubin levels and the development of pathological hyperbilirubinemia in newborns with a P-value of 0.000. A critical cord bilirubin level ≥ 2.50mg/dl has sensitivity of 84.1%, specificity of 88.5%, positive predictive value of 98% and negative predictive value of 45.1% for predicting the risk of developing pathological jaundice.Conclusions: This study concludes that cord blood total bilirubin levels reliably predict the occurrence of pathological hyperbilirubinemia as defined by current operational guidelines.
45
Xiping, Zhang, Weng Ke, Yu Yaping, Zhao Hongchan, and Cheng Qihui. "Protective Effect and Mechanisms of Radix Astragali Injection on the Intestinal Mucosa of Rats with Obstructive Jaundice." Mediators of Inflammation 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/757191.
Full textAbstract:
Objective. To research the protective effects and mechanisms of Radix Astragali injection on the intestinal mucosa of rats with obstructive jaundice (OJ).Methods. The rats were randomly divided into sham-operated, model control and Radix Astragali treated group. We observed the pathological changes of intestinal mucosa, expression levels of Bax and NF-κB proteins, and apoptosis indexes in intestinal mucosa as well as serum NO, MDA and SOD contents, respectively, on 7d, 14d, 21d and 28d after operation.Results. The pathological severity score (on 7d and 14d), apoptotic indexes (on 14d) of the intestinal mucosa and serum MDA content (on 14d) of treated group were significantly lower than those in the model control group (P<.05). The serum SOD contents (on all time points) of treated group were significantly higher than those in the model control group (P<.05). The sham-operated group (on 21d) of the product of staining intensity and positive rate of Bax protein was significantly lower than model control group (P<.05).Conclusion. Radix Astragali injection could protect the intestinal mucosa of OJ rats by increasing the content of SOD, reducing the content of MDA, inhibiting the apoptosis and relieving the pathological changes of intestinal mucosa.
46
Freeman, Hugh J., and Andrew M. Seal. "Survival from Primary Abdominal Lymphoma Presenting with a Mass and Obstructive Jaundice." Canadian Journal of Gastroenterology 10, no. 2 (1996): 89–92. http://dx.doi.org/10.1155/1996/956983.
Full textAbstract:
A 68-year-old female presented with an enlarged and nontender palpable gallbladder and clinical features of obstructive jaundice. Subsequent laboratory investigations confirmed the presence of cholestasis associated with an obstructing mass in the region of the common hepatic duct. Pathological evaluation of the mass revealed a localized abdominal lymphoma. Treatment with chemotherapy and radiation resulted in complete clinical remission (for almost 14 years at the last evaluation). Primary abdominal lymphoma may involve the hilar region and present as a localized mass. Precise tissue diagnosis is essential to permit an aggressive management approach with the potential for significant clinical benefit.
47
Molossi, Franciéli Adriane, Luan Cleber Henker, Bianca Santana De Cecco, Marcele Bettim Bandinelli, Rochana Rodrigues, Luciana Sonne, David Driemeier, and Saulo Petinatti Pavarini. "Pathological and immunohistochemical aspects of acute megakaryoblastic leukaemia in a cat – Short communication." Acta Veterinaria Hungarica 69, no. 2 (July 31, 2021): 175–79. http://dx.doi.org/10.1556/004.2021.00025.
Full textAbstract:
AbstractAn adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia and constipation for three days. Physical examination revealed splenomegaly, cachexia, and dehydration. Humane euthanasia was conducted, followed by postmortem examination. Grossly, the cat was icteric, and presented hepatomegaly with multifocal white spots and splenomegaly. Histologically, the bone marrow was nearly completely replaced by a proliferation of megakaryocytes and megakaryoblasts, and there was a proliferation of fibrous connective tissue. Similar neoplastic proliferation was observed infiltrating the liver, lymph nodes, spleen, kidney, skeletal muscle, and lungs. Immunohistochemistry was performed for von Willebrand Factor (VWF), CD79α, CD3, feline immunodeficiency virus, FeLV, and CD61. Marked cytoplasmic labelling was observed in the neoplastic cells for FeLV, VWF and CD61, corroborating the diagnosis of acute megakaryoblastic leukaemia.
48
Malla, T., S. Singh, P. Poudyal, B. Sathian, G. BK, and K. K. Malla. "A Prospective Study on Exchange Transfusion in Neonatal Unconjugated Hyperbilirubinemia – in a Tertiary Care Hospital, Nepal." Kathmandu University Medical Journal 13, no. 2 (February 25, 2017): 102–8. http://dx.doi.org/10.3126/kumj.v13i2.16781.
Full textAbstract:
Background An exchange transfusion involves replacing patient’s blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume.Objective To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia.Method Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015. For both mothers and neonates blood group and Rh typing and for all newborns pre and post exchange complete blood count with peripheral smear, serum bilirubin, hemoglobin, calcium, potassium, random blood sugar, C-reactive protein and blood culture and where ever required Direct Coombs test, reticulocyte count, G6PD activity and thyroid function test were done. The incidence, indications, positive outcome, complications and mortality were noted.Result Out of 481 cases of unconjugated hyperbilirubinemia 29(6%) required exchange transfusion. 55.2% Pathological Jaundice [13.8% ABO incompatibility, sepsis and hypothyroidism was commonest causes] and 44.8% exaggerated physiological jaundice [27.6% with no underlying pathology, 10.3% preterms 3.4% cephalhematoma] required exchange transfusion. Post transfusion, bilirubin level decreased significantly (p<0.001). The commonest adverse events noted were anemia (89.7% / p<0.018), hyperglycemia(51.7% / p<0.001), hypocalcaemia (48.3% /p<0.001)), sepsis(10.3%), hypernatremia (13.8%), hyperkalaemia, bradycardia, apnea and feed intolerance (6.9%). None of them had kernicterus and there was no mortalities.Conclusion Exchange transfusion is an effective procedure to decrease bilirubin levels but is associated with many complications. Hypothyroidism was one of the commonest cause of jaundice requiring Exchange transfusion.
49
Procianoy, Renato, Rita Silveira, and Fabrízia Faulhaber. "Side Effects of Phototherapy on Neonates." American Journal of Perinatology 36, no. 03 (August 6, 2018): 252–57. http://dx.doi.org/10.1055/s-0038-1667379.
Full textAbstract:
AbstractPhototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years. Through this review, we seek to analyze what we know about the side effects of phototherapy in the neonatal period. The main causes of jaundice, phototherapy techniques, acute and late side effects, and effects on the immune and inflammatory system were reviewed. It was concluded that phototherapy is not a treatment free of side effects and further studies need to be conducted to elucidate its harmful effects on neonates.
50
Serra de Almeida, Nuno, Crisbety Pinho, Diogo Faim, and Raquel Henriques. "Haemolytic disease of the fetus and newborn: do not miss a positive maternal antierythrocyte antibody screen." BMJ Case Reports 14, no. 7 (July 2021): e242731. http://dx.doi.org/10.1136/bcr-2021-242731.
Full textAbstract:
Jaundice is one of the most common situations during the neonatal period. Alloimmune haemolytic disease of the fetus and newborn (AHDFN) is a major cause of pathological jaundice during the neonatal period. Since the establishment of anti-D prophylaxis, other antigens have gained greater clinical importance. The maternal antierythrocyte antibody screen is of great importance in monitoring pregnancy and in predicting the risk of AHDFN. A positive result should alert to the possibility of AHDFN and promote close surveillance of fetal anaemia, as well as neonatal anaemia and hyperbilirubinaemia. We describe a case of AHDFN due to incompatibility of the Rhesus c (Rhc) subgroup, diagnosed in pregnancy, but without effective transmission of information in the perinatal period, so a positive maternal antierythrocyte antibody screen was missed. This case highlights the importance of non-RhD antigens in this disease, but also the importance of a successful handoff of information in the delivery room.