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Relevant bibliographies by topics / Pathology pregnancy / Dissertations / Theses

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Dissertations / Theses on the topic 'Pathology pregnancy'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Khan, Akmal. "Pregnancy related maternal deaths at Salt River Forensic Pathology Laboratory: a 5 year retrospective study of the epidemiological data and spectrum of pathology and disease in all pregnancy related deaths at Salt River Pathology Laboratory irrespect." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/6662.

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Includes abstract.<br>Includes bibliographical references.<br>Death of women whilst pregnant and in the post-partum period is a huge burden of disease in South Africa. All confidential enquiries and research into pregnancy related deaths in South Africa have focused on examining the cases based on the WHO definition of maternal death and have excluded deaths from incidental or accidental causes. Pregnancy related deaths due to suicide, homicide and accidental causes have predominantly only been studied in first world countries. There is minimal data available for developing countries like Sout

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2

Tanyanyiwa, Donald Moshen. "Apolipoprotein E variants, plasma lipids, lipoproteins and dysApolipoprotein E variants, plasma lipids, lipoproteins and dysβLipoproteinaemia during pregnancy in Zimbabwean women". Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/2703.

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Includes bibliographical references (leaves 117-138).<br>This study of pregnant women in Zimbabwe therefore set itself the following aims: To describe lipid and lipoproteins during and after pregnancy, To examine the prevalence of apoE variants, To evaluate dysβlipoproteinaemia in pregnancy, The correlation between dysβplipoproteinaemia and the apoE genotypes. This is the first study to systematically examine lipids and lipoproteins during pregnancy in black Africans.

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3

Smith, Gordon Campbell Sinclair. "Maternal, obstetric, biochemical and ultrasonic associations of normal and abnormal human pregnancy." Thesis, University of Cambridge, 2010. http://theses.gla.ac.uk/3189/.

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The work in this thesis describes a series of studies utilising diverse data sources which were analysed using a number of regression methods (logistic, linear, Cox, Poisson), to address the factors associated with normal and abnormal pregnancy outcome. A series of maternal characteristics were related to adverse pregnancy outcome. Teenage pregnancy was not associated with an increased risk of any adverse outcome among first births, but was strongly associated with adverse outcome among second births [8]. Parity also interacted with body mass index: maternal obesity was associated with an incr

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4

Childs, Caroline Elizabeth. "The effect of gender, pregnancy and diet upon rat tissue fatty acid composition and immune function." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66005/.

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5

Жерновая, Яна Семенівна, Яна Семеновна Жерновая, Yana Semenivna Zhernovaia, Олена Вікторівна Звагельська та Olena Viktorivna Zvahelska. "Ехографічні ознаки внутрішньоутробного інфікування плода". Thesis, Вид-во СумДУ, 2005. http://essuir.sumdu.edu.ua/handle/123456789/6929.

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6

Нікітіна, Ірина Миколаївна, Ирина Николаевна Никитина, Iryna Mykolaivna Nikitina та В. І. Моісеєнко. "Використання донаторів оксиду азоту в комплексній профілактиці затримки розвитку плода". Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/14899.

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7

Ольховик, Віталій Леонідович, Виталий Леонидович Ольховик, Vitalii Leonidovych Olkhovyk та А. М. Хафажа. "Перинатальні ускладнення у першовагітних з передчасним розривом плодових оболонок". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27142.

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Інтранатальний період має велике значення в зниженні материнської та перинатальної захворюваності та смертності. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/27142

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8

Коваленко, Е. О., та М. Л. Сятиня. "Актуальні питання медикаментозної терапії ускладнень вагітності та пологів". Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/14920.

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Ускладнення вагітності та пологів є важливою медико-соціальною проблемою сучасності, що впливає на ефективність та безпеку збереження здоров’я майбутнього покоління. За Міжнародною класифікацією хвороб 10-го перегляду МКХ-10 (2007 р.) до них відносять патології вагітності, пологів та післяпологового періоду (О00-О99). В Україні найчастіше зустрічаються передчасні пологи (O60), передчасний розрив плідних оболонок (O42), кровотечі в ранні строки вагітності (O20), плацентарні порушення (O43) та викликані вагітністю набряки (O12). При цитуванні документа, використовуйте посилання http://essuir.sum

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9

Голубнича, Вікторія Миколаївна, Виктория Николаевна Голубничая та Viktoriia Mykolaivna Holubnycha. "Використання показника інтенсивності обсіменіння в якості діагностичного критерію при кандидозній інфекції у вагітних". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/5044.

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10

Gebhardt, G. S. "Genetic aspects of pre-eclampsia : mutation screening of the low-density lipoprotein receptor, methylenetetrahydrofolate reductase, prothrombin and factor V candidate genes." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52284.

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Thesis (MSc)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Pre-eclampsia is a condition unique to pregnancy and primarily affects the maternal and placental vascular endothelium. It has significant morbidity and mortality consequences for both mother and infant. Despite global research into the aetiology of the condition, the cause for this condition remains unknown. Several factors, including a strong family history of hypertension in pregnancy point to a familial or genetic component in the pathophysiology of this complication. The purpose of this research project was to invest

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11

Bailey, B., David Wood, Andrea Clements, et al. "Poly-drug Use and Other Risk Factors Among Women Receiving MAT During Pregnancy: Challenges for Research on Health and Developmental Effects in Infancy and Beyond." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/1816.

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12

Andersson, Marie. "Immunopathogenesis of relapsing fever borreliosis." Doctoral thesis, Umeå universitet, Molekylärbiologi (Medicinska fakulteten), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1968.

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Relapsing fever (RF) is caused by different species of Borrelia transmitted by soft ticks or by the human body louse. Illness is characterized by reappearing peaks of high concentrations of spirochetes in blood, concordant with fever peaks separated by asymptomatic periods. Neuroborreliosis is one of the most severe manifestations of RF borreliosis. To understand the immune response during early RF, we analyzed immune cells in brain and kidney of mice infected with B. crocidurae during the acute infection. Our results indicate that brain defense is comprised primarily of innate immune cells. D

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13

Polettini, Jossimara [UNESP]. "Análise quantitativa da expressão de citocinas inflamatórias em membranas corioamnióticas de gestantes com rotura prematura de membranas pré-termo." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/98434.

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Made available in DSpace on 2014-06-11T19:29:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-16Bitstream added on 2014-06-13T19:59:17Z : No. of bitstreams: 1 polettini_j_me_botfm.pdf: 2194860 bytes, checksum: a731ea318ab122b9bf8331b8c84cfef9 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A Rotura Prematura de Membranas Pré-Termo (RPM-PT) é um dos principais problemas da Clínica Obstétrica, com etiologia relacionada à ascensão bacteriana do trato genital inferior para a decídua e mem

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Polettini, Jossimara. "Análise quantitativa da expressão de citocinas inflamatórias em membranas corioamnióticas de gestantes com rotura prematura de membranas pré-termo /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/98434.

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Orientador: Márcia Guimarães da Silva<br>Banca: Maria Terezinha Serrão Peraçoli<br>Banca: José Antonio Simões<br>Resumo: A Rotura Prematura de Membranas Pré-Termo (RPM-PT) é um dos principais problemas da Clínica Obstétrica, com etiologia relacionada à ascensão bacteriana do trato genital inferior para a decídua e membranas corioamnióticas. Objetivo: quantificar a expressão das citocinas inflamatórias interleucina (IL) -1b, IL-6, IL-8 e fator de necrose tumoral (TNF-a) pelas membranas corioamnióticas de gestantes com RPM-PT, e avaliar a correlação dessa expressão com a presença e intensidade d

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15

Bailey, Beth A., David Wood, Andrea Clements, et al. "Polydrug Use and Other Risk Factors Among Women Receiving MAT During Pregnancy: Challenges for Research on Health and Developmental Effects in Infancy and Beyond." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/7665.

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16

Anto, Enoch Odame. "Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2317.

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Preeclampsia (PE) is the leading cause of poor maternal and perinatal outcomes in both developed and developing countries. Even though the condition is treatable in the developed world, mothers from developing countries still suffer dramatic events due to limited resources. There is the need to identify readily available measures in addition to existing biomarkers that can predict PE. Thus, this thesis evaluated suboptimal health status (SHS) and prospective levels of oxidative stress (OS) biomarkers and angiogenic growth mediators (AGMs) with placental anatomy and pathology in normotensive an

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17

Watson, Joni. "Identification of Transcription Factors GZF3, RFX1, Orf19.3928 as Being Implicated in Candida-Bacterial Interactions." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/honors/261.

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Candida albicans is an opportunistic pathogen that is present in the normal flora in a majority of individuals. One key factor in C. albicans virulence is the ability to change its morphology from yeast to an elongated or hyphal form. The regulation of this morphogenesis relies in part upon quorum sensing (QS) molecules. C. albicans often exists as part of a mixed culture alongside other microbes and is influenced by their presence as well as the presence of QS molecules that they produce. In this study, a library of diploid homozygous transcriptional regulator knockout (TRKO) mutants were scr

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18

Fraga, Laura Fregonassi Ribeiro. "Exame microscópico do cório placentário para o diagnóstico rápido de infecção amniótica." Universidade Federal do Espírito Santo, 2013. http://repositorio.ufes.br/handle/10/5889.

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Made available in DSpace on 2016-12-23T13:55:59Z (GMT). No. of bitstreams: 1 Laura Fregonassi Ribeiro Fraga.pdf: 4567995 bytes, checksum: 80f83feca246031271e511fadd682376 (MD5) Previous issue date: 2013-08-30<br>A infecção amniótica e a corioamnionite (CAM) são determinantes de infecções materna e perinatal, parturição e nascimento pretermo e morbi-mortalidade pós-natal. Embora métodos clínicos, histopatológicos, microbiológicos, bioquímicos e moleculares possam diagnosticar CAM, nenhum logrou amplo emprego, permanecendo muitos casos clínica e epidemiologicamente ocultos. O presente estudo a

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19

Streydio, Catherine. "Structure, évolution et expression de gènes appartenant à la famille des "Pregnancy specific Beta1 glycoprotein"." Doctoral thesis, Universite Libre de Bruxelles, 1991. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212979.

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20

Sartain, Hallie. "ChAT Expression in Chlamydia muridarum-infected Female Murine Genital Tract." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/honors/391.

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Chlamydia trachomatis is the most prevalent agent of bacterial sexually transmitted infections in the world. However, a profuse number of cases are unreported, as the infection is often asymptomatic. Sequelae such as pelvic inflammatory disease, an increased risk of cervical cancer, premature birth, and perinatal infections in pregnant women can occur. Inflammation occurs in the body in response to infection or injury. Although inflammation can lead to some unwanted secondary effects, such as pain, it serves to return the body to homeostasis by restoring injured tissues and eliminating pathoge

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21

Tobias, Lynette. "The pregnant mouse model of brucellosis: the pathology and protection studies comparing Brucella abortus strains 2308, 19 and RB51." Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39917.

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22

Abdel, Azim Hatem Hamdy. "Breast cancer in young women: impact of pregnancy on biology and outcome." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209357.

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In this work, we found that proliferation-related prognostic gene signatures could aid treatment decision-making independent of age. This is clinically relevant for the younger breast cancer population given the potential long-term side effects of adjuvant systemic chemotherapy and hence the need to identify patients who are less likely to benefit adjuvant chemotherapy. In addition, it was clear that young age at diagnosis adds extra biological complexity, which is independent of differences in breast cancer subtype distribution. This includes enrichment with known breast cancer targets like R

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23

Troude, Pénélope. "Devenir à long terme de couples traités par fécondation in vitro dans la cohorte DAIFI." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00933360.

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Les études sur les couples traités par fécondation in vitro (FIV) ont jusqu'à présent porté essentiellement sur l'évaluation du succès en FIV. Très peu de données sont disponibles sur le devenir à long terme de couples traités par FIV. L'objectif de ce travail était d'estimer la fréquence de réalisation du projet parental à long terme, et d'étudier les facteurs associés aux interruptions précoces des traitements et aux naissances naturelles.L'enquête DAIFI-2009 a inclus 6 507 couples ayant débuté un programme de FIV en 2000-2002 dans l'un des 8 centres de FIV participant à l'étude. Les données

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24

Dauby, Nicolas. "Réponse des lymphocytes B lors de l'infection primaire au cytomégalovirus humain pendant la grossesse." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209097.

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L'infection par le cytomégalovirus humain (HCMV) est une cause majeure de mortalité chez les patients immunodéprimés et représente la première cause d'infection congénitale. HCMV est un virus complexe qui s'est adapté au système immunitaire humain en développant de multiples mécanismes d'évasion. L'infection primaire à HCMV est associée à une réplication virale prolongée avant l'établissement de la latence. Il a été montré que cette intense réplication lors de la phase initiale de l'infection était associée à une épuisement fonctionnel des lymphocytes T CD4 spécifiques du virus. Alors que les

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25

Wendremaire, Maeva. "Obésité et grossesse : étude de l'influence d'un marqueur de l'obésité sur les mécanismes cellulaires et tissulaires de l'accouchement dans un modèle d'explants myométriaux humains." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00825497.

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L'obésité maternelle, dont la prévalence ne cesse d'augmenter, est associée à de nombreux troubles de l'accouchement, tels que des dépassements de terme à l'origine d'une augmentation du taux de césariennes. Ces troubles pourraient, en partie, s'expliquer par une concentration plasmatique de leptine plus élevée chez les femmes enceintes obèses ainsi que par les effets inhibiteurs, démontrés in vitro, de cette adipokine sur la contractilité myométriale. Au moment de l'accouchement, la transition phénotypique du myomètre d'un état de quiescence utérine à un état contractile est une étape clé ind

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26

Rabie, Ursula. "The contribution of the placenta to the diagnosis of congenital tuberculosis." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86623.

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Thesis (MMed)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically suspected tuberculosis (TB) had evidence of TB in the placenta. A secondary objective was to correlate evidence of placental TB with neonatal outcome. A total of 56 placentas were examined to determine if there were any specific histopathological features predictive of tuberculosis together with Ziehl-Neelsen (ZN) staining. A total of 30 cases were positive for maternal TB and one case was a false positive maternal diagnosi

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27

Huchon, Cyrille. "Développement d'un autoquestionnaire pour le diagnostic des algies pelviennes aigües." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00691369.

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Les algies pelviennes aigues constituent le premier motif de consultation aux urgences gynécologiques. Les étiologies possibles de ces algies pelviennes aigues sont nombreuses et incluent à la fois des affections gynécologiques et non gynécologiques. Certaines de ces affections peuvent, en l'absence de diagnostic précoce et d'un traitement adapté, avoir des conséquences très graves. Dans ce travail, nous avons développé un autoquestionnaire standardisé de manière qualitative dédié aux urgences gynécologiques par des entretiens structurés. Nous avons ensuite construit des modèles de prédiction

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28

Bernard, Jonathan. "Déterminants nutritionnels précoces du neurodéveloppement des enfants de l'étude EDEN : rôle des acides gras polyinsaturés." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00986264.

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Contexte : De la conception à l'âge adulte, de nombreux déterminants environnementaux influencent le neurodéveloppement. Des études montrent que durant la fin de la grossesse et les premiers mois de vie, une grande quantité d'acides gras polyinsaturés (AGPI), notamment à longue chaîne (AGPI-LC), se fixe dans le tissu cérébral. Un apport optimal durant ces périodes critiques pourrait soutenir précocement le bon développement du cerveau et de ses fonctions.Objectifs : Étudier les relations entre les expositions pré- et postnatales précoces aux AGPI, et le neurodéveloppement d'enfants de 2 et 3 a

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Bahizire, Namegabe Esto. "Anémie en milieu rural au Sud-Kivu :contribution du paludisme et de la carence en fer. Anemia in rural South Kivu: contribution of malaria and iron deficiency." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/273054.

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Résumé généralIntroductionL’anémie est un problème majeur de santé publique particulièrement fréquent dans les pays à faible revenu, dont la RDC, et qui affecte avec prédilection les femmes enceintes et les enfants d’âge préscolaire. Elle est associée à un risque élevé de morbidité et de mortalité. Au cours de la grossesse, l’anémie peut entraver le développement du fœtus et peut affecter négativement la santé maternelle. Chez l’enfant, l’anémie peut en plus altérer le développement physique et mental si elle n’est pas rapidement corrigée. Il est généralement admis que la carence en fer est la

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Goetghebuer, Tessa. "Impact des traitements antirétroviraux hautement actifs sur le devenir des nourrissons nés de mères infectées par le VIH." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209263.

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Depuis la description des premiers cas de SIDA pédiatriques en 1983, d’importants progrès ont été réalisés dans la compréhension des mécanismes de transmission, puis dans la prévention de celle-ci, et dans la connaissance de l’histoire naturelle de l’infection par le VIH chez l’enfant. Depuis 1996 les multithérapies ARV ont permis une diminution considérable de la transmission verticale et de la morbidité et mortalité des enfants infectés par le VIH.<p>Les buts de ce travail ont été :<p>• d’évaluer, dans le contexte de l’offre de soin mise en place dans un centre de référence,<p>l’impact de l’

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Pascalon, Annette. "Influence des deficits energetiques et proteiques sur l'evolution de la gestation et le taux des acides amines libres chez la ratte : effets sur les concentrations de progesterone et de prolactine aux periodes critiques de la mortalite embryonnaire." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF21092.

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32

Compagnon, Anne. "Étude des malformations induites par la pyriméthamine chez le rat : anomalies du développement de la région faciale." Paris 6, 1987. http://www.theses.fr/1987PA060631.

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33

Mirlesse, Véronique. "Diagnostic prénatal et médecine fœtale : Du cadre des pratiques à l’anticipation du handicap. Comparaison France-Brésil." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T043/document.

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Cette thèse analyse les pratiques du diagnostic prénatal (DPN) en France et au Brésil, entre mondialisation des savoirs et des techniques et régulations locales, à la recherche des modalités d’anticipation du handicap. Le DPN s’est développé dans les pays d’Europe et d’Amérique du Nord en lien direct avec les législations sur l’avortement. Il a pris ancrage dans le suivi des grossesses comme l’un des modes de prévention des handicaps à la naissance. Son expansion aux pays où l’accès à l’avortement est restreint oblige à des adaptations fonction des régulations locales. Les dispositifs réglemen

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34

Chartrel, Nicolas. "Identification de quelques facteurs impliqués dans l'induction de l'hypotrophie foetale chez la rate rendue expérimentalement diabétique." Rouen, 1989. http://www.theses.fr/1989ROUES016.

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Etude réalisée pendant la gestation chez la rate rendue diabétique par injection de streptozotocine, dans le but d'identifier quelques facteurs impliqués dans le développement de l'hypotrophie foetale: sont évalués le rôle des perturbations hémodynamiques utéroplacentaires, et l'hypertonie du myomètre, avec les facteurs neuro-endocriniens impliqués dans ces modifications

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Prud'Homme, Marie-Jeanne. "Contribution a l'etude des mecanismes de regulation de la motricite uterine chez la brebis." Paris 6, 1987. http://www.theses.fr/1987PA066591.

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MacPherson, Robert Tod Lenard. "The utility of embryofeto-pathology following surgical terminations of pregnancy." Thesis, 1997. http://hdl.handle.net/2429/7636.

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Embryofeto-pathology examination findings for 521 consecutive pregnancy terminations for fetal abnormalities were compared on the basis of method of termination, results of prenatal cytogenetic investigations, and gestational age at termination. Comparisons were undertaken to ascertain if, as generally assumed, the amenability of the products of conception to embryofeto-pathological examination is less following pregnancy termination by surgical means than following termination by induction. Embryofeto-pathological examination provided a diagnosis that could be used for genetic counseling 42.

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Ray, Jocelyn. "Matador and the Regulation of cyclin E1 in Normal Human Placental Development and Placental Pathology." Thesis, 2010. http://hdl.handle.net/1807/26381.

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Preeclampsia and molar pregnancy are two devastating placental pathologies characterized by an immature proliferative trophoblast phenotype accompanied by excessive cell death. It is therefore of paramount importance to study the regulation of cell fate in the placenta, to gain a further understanding of the mechanisms that contribute to these diseases. In this dissertation we report that during normal placental development and in preeclampsia, Matador (Mtd), a pro-apoptotic member of the Bcl-2 family, has a dual function in regulating trophoblast cell proliferation and death. Importantly, we

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Doré, Vincent. "Impact des niveaux de B-hydroxybutyrate sur la productivité des chèvres laitières." Thèse, 2014. http://hdl.handle.net/1866/11949.

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Wilson, Ann. "The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects." Thesis, 2002. https://vuir.vu.edu.au/16150/.

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Maternai peripheral hyperinsulinemia and fetal hyperinsulinism that occurs as a conséquence of the treatment of diabetic pregnancy hâve been associated with both gross and microscopic, cellular changes. Thèse include an apparent hyperplacentation and fetal macrosomia and trophoblastic morphofunctional pathology, which may contribute to increased morbidity and mortality rates. Reports hâve indicated that fetal and placental macrosomia does not always resuit from maternai hyperglycemia and that insulin m a y stimulate cellular prolifération in vitro. A family of growth factors known as th

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Rainey-Smith, S. R., D. A. Andersson, R. J. Williams, and Marcus Rattray. "Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration." 2010. http://hdl.handle.net/10454/6147.

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The alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor (AMPAR) subunit GluR2, which regulates excitotoxicity and the inflammatory cytokine tumour necrosis factor alpha (TNFalpha) have both been implicated in motor neurone vulnerability in amyotrophic lateral sclerosis/motor neurone disease. TNFalpha has been reported to increase cell surface expression of AMPAR subunits to increase synaptic strength and enhance excitotoxicity, but whether this mechanism occurs in motor neurones is unknown. We used primary cultures of mouse motor neurones and cortical neurones to examine the intera

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