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Relevant bibliographies by topics / Pathway analyses

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Academic literature on the topic 'Pathway analyses'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Pathway analyses"

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Ryan V, William G., Ali Sajid Imami, Hunter Eby, et al. "Interpreting and visualizing pathway analyses using embedding representations with PAVER." Bioinformation 20, no. 7 (2024): 700–704. http://dx.doi.org/10.6026/973206300200700.

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Omics studies use large-scale high-throughput data to explain changes underlying different traits or conditions. However, omics analysis often results in long lists of pathways that are difficult to interpret. Therefore, it is of interest to describe a tool named PAVER (Pathway Analysis Visualization with Embedding Representations) for large scale genomic analysis. PAVER curates similar pathways into groups, identifies the pathway most representative of each group, and provides publication-ready intuitive visualizations. PAVER clusters pathways defined by their vector embedding representations

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Choi, Shing Wan, Judit García-González, Yunfeng Ruan, et al. "PRSet: Pathway-based polygenic risk score analyses and software." PLOS Genetics 19, no. 2 (2023): e1010624. http://dx.doi.org/10.1371/journal.pgen.1010624.

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Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications. While numerous statistical and machine learning methods have been developed to optimise their predictive accuracy, these typically distil genetic liability to a single number based on aggregation of an individual’s genome-wide risk alleles. This results in a key loss of information about an individual’s genetic profile, which could be critical given the functional sub-structure of the genome and the heterog

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Tanabe, Shihori, Sabina Quader, Ryuichi Ono, et al. "Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway." Current Issues in Molecular Biology 47, no. 6 (2025): 466. https://doi.org/10.3390/cimb47060466.

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The coronavirus pathogenesis pathway, which consists of severe acute respiratory syndrome (SARS) coronavirus infection and signaling pathways, including the interferon pathway, the transforming growth factor beta pathway, the mitogen-activated protein kinase pathway, the apoptosis pathway, and the inflammation pathway, is activated upon coronaviral infection. An artificial intelligence approach based on machine learning was utilized to develop models with images of the coronavirus pathogenesis pathway to predict the activation states. Data on coronaviral infection held in a database were analy

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Luo, Mengxian, Chuanmei Zhu, Yujie Xie, et al. "Network and Pathway Analyses of Exercise Therapy on Cerebral Infarction Related Genes." Journal of Physical Medicine and Rehabilitation 6, no. 1 (2024): 26–34. https://doi.org/10.33696/rehabilitation.6.043.

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Background: Few efforts were made to conduct a comprehensive analysis of potential genes within the action of exercise therapy on cerebral infarction (CI). Methods: We used RNA sequencing (RNA-seq) and weighted gene co-expression network analysis (WGCNA) to provide more important insights information than the conventional single-gene analyses. We performed RNA-Seq on the macroscopically preserved and lesioned SD rat CI model (N=4 pairs). The WGCNA constructed a correlation network and identified the modules in the dataset by the dynamic tree-cutting algorithm. We defined the module membership

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Sahajpal, Nikhil Shri, Ashis Mondal, Meenakshi Ahluwalia, et al. "Clinical utility of comprehensive genomic pathway and integrated network analyses in personalized oncology." Journal of Clinical Oncology 38, no. 15_suppl (2020): e14051-e14051. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14051.

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e14051 Background: Adoption of next-generation sequencing (NGS) technology in routine clinical practice has enabled the detection of genetic aberrations such as single nucleotide variants, copy number alterations, and gene fusions. Pathway and network analyses (PNA) are key components for evaluation of NGS data in a clinical setting to explain findings involving thousands of altered genes and proteins with a smaller and more interpretable set of altered processes. Though PNA have been applied to identify driver genes and pathways in cohort-based analyses, its application in precision oncology

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Mok, Kim, Lee, et al. "HisCoM-PAGE: Hierarchical Structural Component Models for Pathway Analysis of Gene Expression Data." Genes 10, no. 11 (2019): 931. http://dx.doi.org/10.3390/genes10110931.

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Although there have been several analyses for identifying cancer-associated pathways, based on gene expression data, most of these are based on single pathway analyses, and thus do not consider correlations between pathways. In this paper, we propose a hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE), which accounts for the hierarchical structure of genes and pathways, as well as the correlations among pathways. Specifically, HisCoM-PAGE focuses on the survival phenotype and identifies its associated pathways. Moreover, its application to real

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Chae, H., M. Kim, and E. Lee. "P014 Bioinformatic analysis of gene expression profiling data on shift work sleep disorder." Sleep Advances 5, Supplement_1 (2024): A34. https://doi.org/10.1093/sleepadvances/zpae070.096.

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Abstract Introduction Shift work sleep disorder (SWSD) is a circadian rhythm sleep disorder affecting individuals who work nontraditional hours, such as night shifts. The complexity of SWSD arises from the altered interactions between thousands of genes, making it challenging to prioritize disease mechanism, biomarkers, and drug targets. This study aims to identify the patterns of pathways and upstream regulators involved in SWSD using a transcriptome from isolated peripheral blood mononuclear cells (PBMCs) of hospital nurses. Method We conducted bioinformatic analyses on the GSE122541 dataset

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Thibodeau, Asa, and Dong-Guk Shin. "TriPOINT: a software tool to prioritize important genes in pathways and their non-coding regulators." Bioinformatics 35, no. 15 (2018): 2686–89. http://dx.doi.org/10.1093/bioinformatics/bty998.

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Abstract Summary Current approaches for pathway analyses focus on representing gene expression levels on graph representations of pathways and conducting pathway enrichment among differentially expressed genes. However, gene expression levels by themselves do not reflect the overall picture as non-coding factors play an important role to regulate gene expression. To incorporate these non-coding factors into pathway analyses and to systematically prioritize genes in a pathway we introduce a new software: Triangulation of Perturbation Origins and Identification of Non-Coding Targets. Triangulati

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Dessie, Eskezeia Y., Lili Ding, Latha Satish, and Tesfaye B. Mersha. "Co-Expression Network and Machine Learning Analysis of Transcriptomics Data Identifies Distinct Gene Signatures and Pathways in Lesional and Non-Lesional Atopic Dermatitis." Journal of Personalized Medicine 14, no. 9 (2024): 960. http://dx.doi.org/10.3390/jpm14090960.

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Background: Atopic dermatitis (AD) is a common inflammatory skin condition with complex origins. Current treatments often yield suboptimal results due to an incomplete understanding of its underlying mechanisms. This study aimed to identify pathway and gene signatures that distinguish between lesional AD, non-lesional AD, and healthy skin. Method: We conducted differential gene expression and co-expression network analyses to identify differentially co-expressed genes (DCEGs) in lesional AD vs. healthy skin, lesional vs. non-lesional AD, and non-lesional AD vs. healthy skin. Modules associated

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Xuan, Huidong, Yanzhong Huang, Li Zhou, et al. "Key Soybean Seedlings Drought-Responsive Genes and Pathways Revealed by Comparative Transcriptome Analyses of Two Cultivars." International Journal of Molecular Sciences 23, no. 5 (2022): 2893. http://dx.doi.org/10.3390/ijms23052893.

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Seedling drought stress is one of the most important constraints affecting soybean yield and quality. To unravel the molecular mechanisms under soybean drought tolerance, we conducted comprehensive comparative transcriptome analyses of drought-tolerant genotype Jindou 21 (JD) and drought-sensitive genotype Tianlong No.1 (N1) seedlings that had been exposed to drought treatment. A total of 6038 and 4112 differentially expressed genes (DEGs) were identified in drought-tolerant JD and drought-sensitive N1, respectively. Subsequent KEGG pathway analyses showed that numerous DEGs in JD are predomin

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Dissertations / Theses on the topic "Pathway analyses"

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Kretschmer, Tina. "Pathway to adolescents' value acquisition : Within- and between-family analyses." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506934.

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Strickland, Natalie Judith. "In silico and functional analyses of the iron metabolism pathway." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79871.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Iron is an essential micronutrient that is an absolute requirement for correct cellular function in all eukaryotic organisms. However, ferrous iron has the ability to catalyze the formation of potentially toxic reactive oxygen species and regulation of iron metabolism is therefore of critical importance. Currently, there is little known about the co-ordinated regulation of the plethora of genes coding for proteins involved in this biochemical pathway, with the exception of the well characterized post-transcriptional IRE/IRP

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Szalma, Stephen J. "QTL and association analyses of the phenylpropanoid pathway in maize silks /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091971.

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Nyarambi, Arnold, and Q. Godbolt. "The Utility and Effectiveness of Behavioral Data Analyses Techniques: Function Matrix and Triangulation & Problem Behavior Pathway Analysis." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/8268.

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Antoni, Alandes Regina. "Molecular and genetic analyses of the PP2C-ABA receptor interaction in the abscisic acid signaling pathway." Doctoral thesis, Universitat Politècnica de València, 2013. http://hdl.handle.net/10251/29756.

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La fitohormona ácido abscísico (ABA) juega un papel crucial en el control de la respuesta a estrés y en la regulación del crecimiento y desarrollo de la planta. La unión del ABA a los receptores intracelulares PYR/PYL/RCAR conlleva la inhibición de las PP2Cs del clado A tales como ABI1 o HAB1, causando la activación de la ruta de señalización del ABA. Para obtener más información en la señalización del ABA nos hemos centrado en la caracterización de miembros de estas dos familias proteicas. Hemos generado una versión mutada de HAB1 que contiene una mutación en el Trp-385, residuo cla

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Laville, Vincent. "Analyses génomiques de données sur le vieillissement cutané." Thesis, Paris, CNAM, 2015. http://www.theses.fr/2015CNAM1006/document.

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La peau est un excellent modèle d’étude du vieillissement général. En plus de facteurs environnementaux, les facteurs génétiques jouent un rôle majeur dans le vieillissement cutané. Dans le cadre de ma thèse, j’ai eu accès à une cohorte exceptionnelle de 502 femmes caucasiennes très bien caractérisées sur le plan cutané, pour effectuer deux études d’association « génome-entier ». La première étude a montré le rôle joué par le système immunitaire, et en particulier le gène HLA‑C, dans la sévérité des lentigines du visage. La seconde a mis en évidence une association entre le gène H2AFY2 et la s

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Cruz, Christian D. "Wheat blast: quantitative pathway analyses for the Triticum pathotype of Magnaporthe oryzae and phenotypic reaction of U.S. wheat cultivars." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16387.

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Doctor of Philosophy<br>Department of Plant Pathology<br>William W. Bockus<br>James P. Stack<br>Wheat blast, caused by the Triticum pathotype of Magnaporthe oryzae (MoT), is a serious disease of wheat causing yield failures and significant economic losses during epidemic years in Brazil, Paraguay, and Bolivia. Although outbreaks occur only sporadically, wheat blast is considered a major disease affecting wheat production in South America and may be a threat to the wheat crop in the United States. Wheat is a major crop in the U.S. and wheat exports from the U.S. are important to food security o

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Hilbert, Magdalena [Verfasser], and Regine [Akademischer Betreuer] Kahmann. "Biochemical and molecular analyses of the biosynthesis pathway of the indole derivatives in Piriformospora indica / Magdalena Hilbert. Betreuer: Regine Kahmann." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1032314494/34.

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Yuan, Yijun. "Functional study of oil assembly pathway in oil palm (Elaeis guineensis Jacq.) fruits." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0158/document.

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Le palmier à huile est la première culture oléagineuse, avec environ 40% de la production mondiale, et son fruit accumule deux huiles de composition très différente dans le mésocarpe et l’amande. Chez les plantes, les acides gras sont assemblés en huile dans le réticulum endoplasmique, ceci par la voie dite de Kennedy à laquelle s’ajoutent des mécanismes d’édition impliquant le métabolisme de la phosphatidylcholine. Nous avons utilisé les outils de la lipidomique pour analyser la variabilité au sein de différentes populations de palmier ainsi que pour caractériser l’accumulation d’huile durant

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Steinberg, Julia. "Functional genomics analyses of neuropsychiatric and neurodevelopmental disorders." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e47d1ac2-de92-47d8-864b-dac0bf6669e8.

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Recent large-scale genome-wide studies for many human disorders have identified associations with numerous genetic variants. The biological interpretation of these variants presents a major challenge. In particular, the identification of biological pathways underlying the association could provide crucial insights into the disease aetiologies. In this thesis, I used functional genomics approaches to increase our understanding of neuropsychiatric and neurodevelopmental disorders. Firstly, in an integrative analysis of autism spectrum disorder (ASD), I looked into the role of genes targeted by F

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Books on the topic "Pathway analyses"

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E, Letkeman John, Musumeci Grace M, United States. Environmental Protection Agency., and Radian Corporation, eds. Superfund air pathway analyses: Review criteria checklists. U.S. Environmental Protection Agency, Region II, 1990.

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United States. Office of Solid Waste., ed. Petroleum refining process waste listing determination: Additional groundwater pathway risk analyses : supplemental background document. U.S. Environmental Protection Agency, Office of Solid Waste, 1998.

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Wall, Deborah K. Critical pathway implementation guide: A methodology for managing critical pathways. Precept Press, 1997.

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United States. Environmental Protection Agency. Office of Emergency and Remedial Response. and United States. Environmental Protection Agency. Office of Research and Development., eds. Air pathway analysis. U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, 1993.

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United States. Environmental Protection Agency. Office of Emergency and Remedial Response. and United States. Environmental Protection Agency. Office of Research and Development., eds. Air pathway analysis. U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, 1993.

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United States. Environmental Protection Agency. Office of Emergency and Remedial Response and United States. Environmental Protection Agency. Office of Research and Development, eds. Air pathway analysis. U.S. Environmental Protection Agency, Office of Emergency and Remedial Response, 1993.

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Tatarinova, Tatiana V., and Yuri Nikolsky, eds. Biological Networks and Pathway Analysis. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7027-8.

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Nikolsky, Yuri, and Julie Bryant, eds. Protein Networks and Pathway Analysis. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-175-2.

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Yuryev, Anton, ed. Pathway Analysis for Drug Discovery. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470399279.

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Wall, Deborah K. Critical pathways: Moving from parameters to pathways : a guide for developing and implementing critical pathways. Quality Team Associates, 1994.

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Book chapters on the topic "Pathway analyses"

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Angers, Stephane. "Proteomic Analyses of Protein Complexes in the Wnt Pathway." In Methods in Molecular Biology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-249-6_17.

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Klomp, Jeff A., Bin T. Teh, and Kyle A. Furge. "An Integrated Oncogenomic Approach: From Genes to Pathway Analyses." In An Omics Perspective on Cancer Research. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2675-0_3.

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Bonetta Valentino, Rosalin, Jean-Paul Ebejer, and Gianluca Valentino. "Machine Learning Using Neural Networks for Metabolomic Pathway Analyses." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2617-7_17.

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Corneliussen, Hilde G. "Women’s Chronological Pathways to IT Education." In Reconstructions of Gender and Information Technology. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-5187-1_3.

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AbstractWhat are the key factors and driving forces that make women enter the fields of information technology (IT), despite the many gendered barriers revisited in Chap. 2? This chapter analyses the narratives of 24 women’s chronological pathways from childhood to entering a university degree in IT. The chapter illustrates six different pathways that led the women to pursue a degree in IT, each analysed in terms of the positive drivers, including interest in IT, recruitment measures, an accidental choice, finding a safe platform in other disciplines, and a detour before discovering IT. Only o

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Apunike, Anderson C., Lívia Oliveira-Ciabati, Tiago L. M. Sanches, et al. "Analyses of Public Health Databases via Clinical Pathway Modelling: TBWEB." In Lecture Notes in Computer Science. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50423-6_41.

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Njeru, Mercy Karimi, Maureen Mackintosh, Richard Ngilangwa, Sharon Mokua, Richard Mutisya Arun, and Jane Mukami. "Access to Cancer Care: Navigating the Maze." In Cancer Care in Pandemic Times: Building Inclusive Local Health Security in Africa and India. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44123-3_4.

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AbstractThis chapter analyses narratives from over 450 patients in Kenya and Tanzania, describing their cancer “pathways”, drawing also on views from carers and health workers. We characterise patients’ experiences as, too often, finding themselves in a “maze” after they first visit a health facility. Rather than a smooth clinical pathway from symptoms to diagnosis, patients had found themselves struggling to find money to move through a confusing health system maze, largely without maps or guides to aid their search for information, diagnosis and treatment. The chapter describes patterns of e

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Perles-Ribes, José F., and Josep A. Ivars-Baidal. "The Pathway from Smartness to Sustainability: Exploring the Transmission Mechanisms." In Information and Communication Technologies in Tourism 2021. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65785-7_39.

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AbstractSmartness and sustainability have many points in common. Recent literature suggests that smartness would be a possibility to achieve the desired sustainability of tourist destinations. This article reviews the theoretical mechanisms that link both concepts and analyses their importance for a set of smart cities an destinations in Spain.

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Ni, Lisheng, and Xuelian Luo. "Structural and Biochemical Analyses of the Core Components of the Hippo Pathway." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8910-2_18.

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Huang, Xiaoqian, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, and Zhiyuan Gong. "Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery." In Cancer and Zebrafish. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30654-4_7.

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Mustafa, Mahreen. "Integrating Life Cycle Analyses and Circular Economy: A Pathway Towards Sustainable Development in Bangladesh." In World Sustainability Series. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-85300-5_15.

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Conference papers on the topic "Pathway analyses"

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Park, Minseong, Hegwon Chung, and Jiyong Kim. "Comparative Techno-economic Assessment of Hydrogen Production, Storage and Refueling Pathways." In Foundations of Computer-Aided Process Design. PSE Press, 2024. http://dx.doi.org/10.69997/sct.119682.

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Hydrogen, as a clean and versatile energy carrier, holds immense promise for addressing the world�s growing energy and environmental challenges. However, hydrogen-based energy systems face challenges related to efficient storage methods, energy-intensive production, refueling processes, and overall cost-effectiveness. To solve this problem, a superstructure was developed that integrates overall technologies related to hydrogen energy transportation. This study synthesizes process pathways for hydrogen energy transportation method including energy carrier production, storage, and refueling, bas

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Laliwala, Chris, and Ana I. Torres. "Design and Optimization of Processes for Recovering Rare Earth Elements from End-of-Life Hard Disk Drives." In Foundations of Computer-Aided Process Design. PSE Press, 2024. http://dx.doi.org/10.69997/sct.123161.

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As the United States continues efforts to decarbonize the power and transportation sectors, significant challenges associated with the reliance of clean energy technologies on rare earth elements (REEs) will have to be overcome. One potential approach for increasing the supply of these elements is to extract REEs from end-of-life (EOL) hard disk drives (HDDs). HDDs contain neodymium and praseodymium, which are among the most important REEs for the clean energy transition, as they are crucial to producing the permanent magnets needed for wind turbines and electric vehicles. Here, we propose a s

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Faith, Seth A., Angela Minard-Smith, Craig Bartling, Nicholas Linn, and Anne Marie Gregg. "Corrosion in Underground Storage Tanks for Ultra Low Sulfur Diesel (ULSD) Fuels." In CORROSION 2014. NACE International, 2014. https://doi.org/10.5006/c2014-3961.

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Abstract Recent federal regulations have mandated the use of ultra-low sulfur diesel fuel (ULSD) that contains sulfur levels no greater than 15 ppm in North America. While the lower sulfur content has dramatically decreased toxic sulfur emissions from diesel vehicles, other unintended consequences have emerged, such as severe and rapid corrosion in underground storage tanks (USTs) that contain ULSD. The corrosion has been reported to present itself in as little as six months and can result in failure of the tanks and components. This report shows the results of chemical, microbiological (e.g.,

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Hariri, Mohiedin Bagheri, Bruce Brown, and Srdjan Nesic. "Revisiting the Anodic Dissolution of Pure Iron in Strong Acids." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17681.

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Abstract The goal of the research reported herein was to accomplish a quantitative mechanistic analysis of iron dissolution in strong acid in a potential range in the proximity of its open circuit potential (OCP), leading to articulation of a revised narrative of BDD† mechanism for iron dissolution; additional mechanistic pathways were postulated in addition to the hypothesized mechanisms of BDD and Heusler. Thirty-eight different pathways were investigated here and theoretical Butler-Volmer equations were written for each. The kinetic consequences of each pathway and the corresponding theoret

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Duffy, Timothy, Derek M. Hall, Serguei N. Lvov, and Margaret Ziomek-Moroz. "Modeling of Current Paths in Advanced Electrochemical Sensors for Improving Corrosion Data Interpretation." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13395.

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Abstract Proton conductive membrane-based sensors allow for electrochemical measurements in low-water content environments. However, electrode placement on the membrane promotes unconventional current pathways. As such, electrode and membrane geometries can impact electrochemical analysis of corrosion and conductivity measurements. In conventional sensors, the current carried by ions in the conducting media is able to travel in a 1-dimensional path between the electrode surfaces, and so the current path between these electrodes are uniform. However, advanced sensors with membranes laid atop th

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Avendano, Marco E., Jianpei Lao, Qiang Fu, Sankar Nair, and Matthew J. Realff. "Environmental Impact of Simulated Moving Bed (SMB) on the Recovery of 2,3-Butanediol on an Integrated Biorefinery." In Foundations of Computer-Aided Process Design. PSE Press, 2024. http://dx.doi.org/10.69997/sct.121375.

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2,3 butanediol (BDO) has garnered recent interest due to the high titer concentrations that can be obtained through biochemical routes and its potential for efficient conversion into long-chain hydrocarbons. BDO separation, however, is challenging given its low volatility and high affinity towards water. In this study, two BDO separation pathways were compared, single distillation and combined simulated moving bed (SMB) adsorption with distillation. The separations were incorporated into a 2018 biorefinery design developed by the National Renewable Energy Laboratory (NREL) to produce renewable

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Ponsiglione, Alfonso Maria, Andrea Fidecicchi, Ida Santalucia, et al. "Management of surgical patient pathway: a quantitative analysis." In 2024 8th International Conference on Biomedical Engineering and Applications (ICBEA). IEEE, 2024. http://dx.doi.org/10.1109/icbea62825.2024.00042.

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Rout, Trilochan, Sujata Chakravarty, and Dillip Kumar Muduly. "Bioinformatics in Cancer: Key Proteins and Pathway Analysis." In 2024 International Conference on Artificial Intelligence and Emerging Technology (Global AI Summit). IEEE, 2024. https://doi.org/10.1109/globalaisummit62156.2024.10947804.

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Ruth, Mark F., Victor Diakov, Melissa J. Laffen, and Thomas A. Timbario. "Projected Cost, Energy Use, and Emissions of Hydrogen Technologies for Fuel Cell Vehicles." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33185.

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Each combination of technologies necessary to produce, deliver, and distribute hydrogen for transportation use has a corresponding levelized cost, energy requirement, and greenhouse gas emission profile depending upon the technologies’ efficiencies and costs. Understanding the technical status, potential, and tradeoffs is necessary to properly allocate research and development (R&D) funding. In this paper, levelized delivered hydrogen costs, pathway energy use, and well-to-wheels (WTW) energy use and emissions are reported for multiple hydrogen production, delivery, and distribution pathwa

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Chang, Matthew T., Thijs J. Hagenbeek, Jennifer Lacap, Zora Modrusan, Christiaan Klijn, and Anwesha Dey. "Abstract PR08: Systematic pan-cancer analyses of Hippo pathway deregulation in cancer." In Abstracts: AACR Special Conference on the Hippo Pathway: Signaling, Cancer, and Beyond; May 8-11, 2019; San Diego, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3125.hippo19-pr08.

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Reports on the topic "Pathway analyses"

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Sabatini, David M. Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2-Mediated Regulation of the mTORC Pathway. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada542265.

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Sabatini, David M. Structural and Mechanistic Analyses of TSC1/2 and Rheb 1/2-Mediated Regulation of the mTORC Pathway. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada510086.

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Yompakdee, Chulee, and Warintorn Chavasiri. An active compound Kempferia parviflora with inhibitory activity against GSK-3 kinase implicated in type II Diabetes and Alzheimer's disease. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.37.

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Calcium signaling pathways play pivotal roles in regulation of various important biological processes in eukaryotes ranging from yeast to human. Because of the high degree in gene conservation from yeast to human, the small molecule inhibitors discovered in the yeast based-drug screening system can be expected to exert their function in human as well. The immunosuppressive agents, FK506 and cyclosporine A, are an example. Our previous studies using a zds1 yeast-based assay to search for inhibitors in the calcium signaling pathway in Saccharomyces cerevisae mutant strain from the crude extract

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Barash, Itamar, and Robert Rhoads. Translational Mechanisms Governing Milk Protein Levels and Composition. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7696526.bard.

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Original objectives: The long-term goal of the research is to achieve higher protein content in the milk of ruminants by modulating the translational apparatus of the mammary gland genetically, nutritionally, or pharmacologically. The short-term objectives are to obtain a better understanding of 1) the role of amino acids (AA) as regulators of translation in bovine and mouse mammary epithelial cells and 2) the mechanism responsible for the synergistic enhancement of milk-protein mRNA polyadenylation by insulin and prolactin. Background of the topic: In many cell types and tissues, individual A

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Lers, Amnon, and Gan Susheng. Study of the regulatory mechanism involved in dark-induced Postharvest leaf senescence. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7591734.bard.

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Postharvest leaf senescence contributes to quality losses in flowers and leafy vegetables. The general goal of this research project was to investigate the regulatory mechanisms involved in dark-induced leaf senescence. The regulatory system involved in senescence induction and control is highly complex and possibly involves a network of senescence promoting pathways responsible for activation of the senescence-associated genes. Pathways involving different internal signals and environmental factors may have distinctive importance in different leaf senescence systems. Darkness is known to have

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Banga, Karishma, and Sherillyn Raga. Digital Trade for Post-COVID Recovery and Resilience in the Commonwealth. Commonwealth Secretariat, 2021. https://doi.org/10.14217/comsec.329.

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Digital trade is increasingly touted as a key pathway for mitigating economic losses from COVID-19. On the one hand, the pandemic has accelerated the scope of a digital-led recovery; on the other, the existing digital divide across countries has been exacerbated by a sudden and increased reliance on digital technologies. This paper aims to deepen the understanding of the contribution digital trade can make in supporting a post-COVID economic recovery in the Commonwealth, and to situate this within the context of the diversity of challenges involved in growing digital trade and expanding the di

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Galili, Gad, Harry J. Klee, and Asaph Aharoni. Elucidating the impact of enhanced conversion of primary to secondary metabolism on phenylpropanoids secondary metabolites associated with flavor, aroma and health in tomato fruits. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597920.bard.

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• Targeted manipulating Phenylalanine (Phe) synthesis is one of the most powerful strategies to boost the biologically and economically important secondary metabolites, including phenylpropaniods, aromatic volatiles and specialized secondary metabolites. • Over-expression of the petunia MYB transcript factor, ODORANT1 (ODO1), results in significant alterations of the levels of specific phenylpropanoid compounds in plants. • Our previous studies indicated that ectopic expression of the feedback-insensitive AroG could break the bottleneck between primary and secondary metabolisms in tomato, ther

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Black, Richard, Joshua Busby, Geoffrey D. Dabelko, et al. Environment of Peace: Security in a New Era of Risk. Stockholm International Peace Research Institute, 2022. http://dx.doi.org/10.55163/lcls7037.

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The environmental crisis is increasing risks to security and peace worldwide, notably in countries that are already fragile. Indicators of insecurity such as the number of conflicts, the number of hungry people and military expenditure are rising; so are indicators of environmental decline, in climate change, biodiversity, pollution and other areas. In combination, the security and environmental crises are creating compound, cascading, emergent, systemic and existential risks. Without profound changes of approach by institutions of authority, risks will inevitably proliferate quickly. Environm

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Whicker, F. W., and T. B. Kirchner. Final report on the Pathway Analysis Task. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/491519.

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Matthews, Lisa, Guanming Wu, Robin Haw, et al. Illuminating Dark Proteins using Reactome Pathways. Reactome, 2022. http://dx.doi.org/10.3180/poster/20221027matthews.

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Diseases are often the consequence of proteins or protein complexes that are non-functional or that function improperly. An active area of research has focused on the identification of molecules that can interact with defective proteins and restore their function. While 22% percent of human proteins are estimated to be druggable, less than fifteen percent are targeted by FDA-approved drugs, and the vast majority of untargeted proteins are understudied or so-called "dark" proteins. Elucidation of the function of these dark proteins, particularly those in commonly drug-targeted protein families,

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