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Dissertations / Theses on the topic 'Pathway analyses'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kretschmer, Tina. "Pathway to adolescents' value acquisition : Within- and between-family analyses." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506934.

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2

Strickland, Natalie Judith. "In silico and functional analyses of the iron metabolism pathway." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79871.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Iron is an essential micronutrient that is an absolute requirement for correct cellular function in all eukaryotic organisms. However, ferrous iron has the ability to catalyze the formation of potentially toxic reactive oxygen species and regulation of iron metabolism is therefore of critical importance. Currently, there is little known about the co-ordinated regulation of the plethora of genes coding for proteins involved in this biochemical pathway, with the exception of the well characterized post-transcriptional IRE/IRP

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3

Szalma, Stephen J. "QTL and association analyses of the phenylpropanoid pathway in maize silks /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091971.

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4

Nyarambi, Arnold, and Q. Godbolt. "The Utility and Effectiveness of Behavioral Data Analyses Techniques: Function Matrix and Triangulation & Problem Behavior Pathway Analysis." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/8268.

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5

Antoni, Alandes Regina. "Molecular and genetic analyses of the PP2C-ABA receptor interaction in the abscisic acid signaling pathway." Doctoral thesis, Universitat Politècnica de València, 2013. http://hdl.handle.net/10251/29756.

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La fitohormona ácido abscísico (ABA) juega un papel crucial en el control de la respuesta a estrés y en la regulación del crecimiento y desarrollo de la planta. La unión del ABA a los receptores intracelulares PYR/PYL/RCAR conlleva la inhibición de las PP2Cs del clado A tales como ABI1 o HAB1, causando la activación de la ruta de señalización del ABA. Para obtener más información en la señalización del ABA nos hemos centrado en la caracterización de miembros de estas dos familias proteicas. Hemos generado una versión mutada de HAB1 que contiene una mutación en el Trp-385, residuo cla

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6

Laville, Vincent. "Analyses génomiques de données sur le vieillissement cutané." Thesis, Paris, CNAM, 2015. http://www.theses.fr/2015CNAM1006/document.

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La peau est un excellent modèle d’étude du vieillissement général. En plus de facteurs environnementaux, les facteurs génétiques jouent un rôle majeur dans le vieillissement cutané. Dans le cadre de ma thèse, j’ai eu accès à une cohorte exceptionnelle de 502 femmes caucasiennes très bien caractérisées sur le plan cutané, pour effectuer deux études d’association « génome-entier ». La première étude a montré le rôle joué par le système immunitaire, et en particulier le gène HLA‑C, dans la sévérité des lentigines du visage. La seconde a mis en évidence une association entre le gène H2AFY2 et la s

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7

Cruz, Christian D. "Wheat blast: quantitative pathway analyses for the Triticum pathotype of Magnaporthe oryzae and phenotypic reaction of U.S. wheat cultivars." Diss., Kansas State University, 2013. http://hdl.handle.net/2097/16387.

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Doctor of Philosophy<br>Department of Plant Pathology<br>William W. Bockus<br>James P. Stack<br>Wheat blast, caused by the Triticum pathotype of Magnaporthe oryzae (MoT), is a serious disease of wheat causing yield failures and significant economic losses during epidemic years in Brazil, Paraguay, and Bolivia. Although outbreaks occur only sporadically, wheat blast is considered a major disease affecting wheat production in South America and may be a threat to the wheat crop in the United States. Wheat is a major crop in the U.S. and wheat exports from the U.S. are important to food security o

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8

Hilbert, Magdalena [Verfasser], and Regine [Akademischer Betreuer] Kahmann. "Biochemical and molecular analyses of the biosynthesis pathway of the indole derivatives in Piriformospora indica / Magdalena Hilbert. Betreuer: Regine Kahmann." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1032314494/34.

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9

Yuan, Yijun. "Functional study of oil assembly pathway in oil palm (Elaeis guineensis Jacq.) fruits." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0158/document.

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Le palmier à huile est la première culture oléagineuse, avec environ 40% de la production mondiale, et son fruit accumule deux huiles de composition très différente dans le mésocarpe et l’amande. Chez les plantes, les acides gras sont assemblés en huile dans le réticulum endoplasmique, ceci par la voie dite de Kennedy à laquelle s’ajoutent des mécanismes d’édition impliquant le métabolisme de la phosphatidylcholine. Nous avons utilisé les outils de la lipidomique pour analyser la variabilité au sein de différentes populations de palmier ainsi que pour caractériser l’accumulation d’huile durant

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10

Steinberg, Julia. "Functional genomics analyses of neuropsychiatric and neurodevelopmental disorders." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e47d1ac2-de92-47d8-864b-dac0bf6669e8.

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Recent large-scale genome-wide studies for many human disorders have identified associations with numerous genetic variants. The biological interpretation of these variants presents a major challenge. In particular, the identification of biological pathways underlying the association could provide crucial insights into the disease aetiologies. In this thesis, I used functional genomics approaches to increase our understanding of neuropsychiatric and neurodevelopmental disorders. Firstly, in an integrative analysis of autism spectrum disorder (ASD), I looked into the role of genes targeted by F

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11

Bayerlová, Michaela [Verfasser], Tim [Akademischer Betreuer] Beißbarth, and Burkhard [Akademischer Betreuer] Morgenstern. "Pathway and network analyses in context of Wnt signaling in breast cancer / Michaela Bayerlová. Betreuer: Tim Beißbarth. Gutachter: Tim Beißbarth ; Burkhard Morgenstern." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/108560196X/34.

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12

Konrad, Attila. "Investigation of Pathway Analysis Tools for mapping omics data to pathways." Thesis, Malmö högskola, Fakulteten för teknik och samhälle (TS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20843.

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Detta examensarbete granskar analysverktyg ur ett tvärvetenskapligt perspektiv. Det finns en hel del olika analysverktyg idag som analyserar specifika typer av omik data och därför undersöker vi hur många det finns samt vad de kan göra. Genom att definiera ett antal specifika krav såsom hur många typer av omik data den kan hantera, noggrannhet av verktygets analys så kan man se vilka som är mest lämpliga analysverktygen när det gäller kartläggning av omik data. Resultaten visar att det idag inte finns analysverktyg som uppfyller de specifikt angivna kraven eller huvudsyftet genom testning av p

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13

Sui, Xueyi. "TRANSCRIPTOMIC ANALYSES OF CATHATRANTHUS ROSEUS HAIRY ROOTS OVEREXPRESSING CRMYC2 AND ORCA3 AND ROLES OF CROSS-FAMILY TRANSCRIPTION FACTOR INTERACTION IN TERPENOID INDOLE ALKALOID BIOSYNTHESIS." UKnowledge, 2017. http://uknowledge.uky.edu/pss_etds/92.

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Catharanthus roseus (Madagascar periwinkle), is a well-known medicinal plant that produces a vast array of terpenoid indole alkaloids (TIAs), including two anticancer compounds vinblastine and vincristine. Industrial scale production of TIAs is hampered by the difficulties of total chemical synthesis of these compounds and the fragmented knowledge on TIA pathway. Transcriptional regulation of the TIA biosynthetic pathway has not been thoroughly investigated in Catharanthus and only a few structural genes have been identified as the targets of two master regulators: the basic helix-loop-helix (

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14

Wright, Alan. "Bayesian pathway analysis in epigenetics." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1286.

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A typical gene expression data set consists of measurements of a large number of gene expressions, on a relatively small number of subjects, classified according to two or more outcomes, for example cancer or non-cancer. The identification of associations between gene expressions and outcome is a huge multiple testing problem. Early approaches to this problem involved the application of thousands of univariate tests with corrections for multiplicity. Over the past decade, numerous studies have demonstrated that analyzing gene expression data structured into predefined gene sets can produce ben

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15

Heijden, Luuk van der. "Determination of the food sources and of the role of meiofauna in soft-bottom intertidal habitats of the Marennes-Oléron Bay, France, and the Sylt-Rømø Bight, Germany : importance of the microphytobenthos-meiofauna pathway, highlighted by community structure, trophic markers and linear inverse food web models." Thesis, La Rochelle, 2018. http://www.theses.fr/2018LAROS030/document.

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La méiofaune joue un rôle important dans le fonctionnement des habitats benthiques à substrat meuble (ex. flux de matière) en relation avec sa production élevée, sa position trophique intermédiaire et les importants transferts d’énergie vers les niveaux trophiques supérieurs qui y sont lié. Les relations trophiques et les flux de matière organique liés à la méiofaune restent néanmoins mal connus ou peu pris en compte. Afin de mieux appréhender le rôle de la méiofaune, la structure des communautés et les relations trophiques entre les sources de nourriture et ces consommateurs ont été déterminé

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16

Hepworth, Joanna Alex. "Comparative analysis of the MAX pathway." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/2550/.

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The pattern of branch outgrowth is a key determinant of the plant body plan. In most angiosperms branching is flexible, as branches are produced from axillary meristems which can either remain dormant or grow out. Strigolactones (SLs), a new class of plant hormones, repress branching in a range of angiosperms, including Arabidopsis, and there is increasing evidence that SLs are regulators of plant development in response to nutrient stress. This study has exploited genetic and physiological methods to investigate the evolution of SL biosynthesis and roles across the four major lineages of vasc

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17

Biesiada, Jacek. "Shiny Application for Enrichment and Topological Pathway Analysis." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595846446399689.

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18

Isik, Zerrin. "Network Structure Based Pathway Enrichment System To Analyze Pathway Activities." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612951/index.pdf.

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Current approaches integrating large scale data and information from a variety of sources to reveal molecular basis of cellular events do not adequately benefit from pathway information. Here, we portray a network structure based pathway enrichment system that fuses and exploits model and data: signalling pathways are taken as the biological models while microarray and ChIP-seq data are the sample input data sources among many other alternatives. Our model- and data-driven hybrid system allows to quantitatively assessing the biological activity of a cyclic pathway and simultaneous enrichment o

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19

Parisi, D. "Analysis of mRNA 3' tagging pathway components." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3021109/.

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20

Evangelou, Marina. "Exploring genomewide association data through pathway analysis." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607999.

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21

Gao, Yipeng. "Transformation Pathway Network Analysis for Martensitic Transformations." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385978073.

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22

Planes, Francisco J. "Metabolic pathway analysis via integer linear programming." Thesis, Brunel University, 2008. http://bura.brunel.ac.uk/handle/2438/6134.

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The understanding of cellular metabolism has been an intriguing challenge in classical cellular biology for decades. Essentially, cellular metabolism can be viewed as a complex system of enzyme-catalysed biochemical reactions that produces the energy and material necessary for the maintenance of life. In modern biochemistry, it is well-known that these reactions group into metabolic pathways so as to accomplish a particular function in the cell. The identification of these metabolic pathways is a key step to fully understanding the metabolic capabilities of a given organism. Typically, metabol

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23

Novak, Barbara Anna. "Quantitative pathway modeling and analysis in cancer." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261242.

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24

Grieco, Luca. "Modélisation et analyse des dérégulations tumorales du réseau MAPK chez l'homme." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4011.

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Le réseau des MAPK est composé de pathways de signalisation fermement entrecroisés impliqués dans le cancer. Toutefois, les mécanismes précis qui sous-tendent son influence sur l'équilibre entre la prolifération et la mort cellulaire demeurent insaisissablesDes données publiques ont été intégrés dans une carte de réactions détaillée, représentant l'influence du réseau des MAPKs sur la décision du destin cellulaire. Cette carte a ensuite été utilisée pour des analyses informatiques spécifiquesTout d'abord, les dynamiques du réseau des MAPKs dans les cancers de la vessie ont été analysés.Un modè

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Chang, Yi Tan. "A Study of Machine Learning Approaches for Integrated Biomedical Data Analysis." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83813.

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This thesis consists of two projects in which various machine learning approaches and statistical analysis for the integration of biomedical data analysis were explored, developed and tested. Integration of different biomedical data sources allows us to get a better understating of human body from a bigger picture. If we can get a more complete view of the data, we not only get a more complete view of the molecule basis of phenotype, but also possibly can identify abnormality in diseases which were not found when using only one type of biomedical data. The objective of the first project is to

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Falb, Michaela. "Computational Genome and Pathway Analysis of Halophilic Archaea." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-47875.

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27

Guizzunti, Gianni. "Functional and chemical analysis of the secretory pathway." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3274506.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed October 4, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 87-93).

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28

Steg, Adam. "Analysis of the hedgehog pathway in pancreatic adenocarinoma." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/steg.pdf.

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29

Cheng, Lulu. "Statistical Methods for Genetic Pathway-Based Data Analysis." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/52039.

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The wide application of the genomic microarray technology triggers a tremendous need in the development of the high dimensional genetic data analysis. Many statistical methods for the microarray data analysis consider one gene at a time, but they may miss subtle changes at the single gene level. This limitation may be overcome by considering a set of genes simultaneously where the gene sets are derived from the prior biological knowledge and are called "pathways". We have made contributions on two specific research topics related to the high dimensional genetic pathway data. One is to propose

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Goel, Gautam. "Dynamic flux estimation a novel framework for metabolic pathway analysis /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31769.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Voit, Eberhard O.; Committee Member: Butera, Robert; Committee Member: Chen, Rachel; Committee Member: Kemp, Melissa; Committee Member: Neves, Ana Rute. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Gong, Yunchen 1965. "Analyses of alternative cell signal transduction pathways." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85552.

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Living cells keep sensing the changes in their environments, mostly, via cell surface receptors for different ligands. Attachment-dependent cells are sensitive to alterations in extracellular matrix (ECM). ECM is not only required for cell survival, but also prerequisite for epidermal growth factor (EGF) to stimulate cell proliferation. The receptors for the majority of ECM components are integrins and the receptor for EGF is EGF receptor (EGFR). When bound by their ligands, integrins and EGFR induce signal transduction cascades composed of alternative pathways. A quantitative assessmen

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Watts, Carys. "Kinetic analysis of the interaction between the QutA and QutR regulatory proteins of Aspergillus nidulans." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246635.

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33

Conners, Shannon Burns. "Carbohydrate utilization pathway analysis in the hyperthermophile Thermotoga maritima." NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-11302005-092748/.

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Carbohydrate utilization and production pathways identified in Thermotoga species likely contribute to their ubiquity in hydrothermal environments. Many carbohydrate-active enzymes from Thermotoga maritima have been characterized biochemically; however, sugar uptake systems and regulatory mechanisms that control them have not been well defined. Transcriptional data from cDNA microarrays were examined using mixed effects statistical models to predict candidate sugar substrates for ABC (ATP-binding cassette) transporters in T. maritima. Genes encoding proteins previously annotated as oligopeptid

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34

Lesurf, Robert. "Molecular pathway analysis of mouse models for breast cancer." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32499.

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Human breast cancer is an extremely heterogeneous disease, consisting of a number of different subtypes with varying levels of aggressiveness reflected by distinct, but largely undefined, molecular profiles. Here we have analyzed several novel mouse models for breast cancer in the context of the human subtypes, and have shown parallels between the mice and humans at numerous biologically relevant levels. In addition, we have developed a statistical framework to help elucidate the individual molecular comp

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35

曾俊傑 and Chun-kit Tsang. "Pathway analysis on electron transfer in ruthenium modified cytochromeC." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31225226.

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Ullah, Ehsan. "Pathway Analysis of Metabolic Networks using Graph Theoretical Approaches." Thesis, Tufts University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3640954.

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<p> Cellular pathways defining biochemical transformational routes are often utilized as engineering targets to achieve industrial-scale production of commercially useful biomolecules including polyesters, building blocks for polymers, biofuels, and therapeutics derived from isoprenoids, polyketides, and non-ribosomal peptides. Identifying target pathways can be expedited using computational tools, leading to reduced development cost, time, and effort, and enabling new discoveries with potential positive impact on human health and the environment. </p><p> This thesis addresses three cellula

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37

Dunwell, Thomas Lawson. "Epigenetic analysis of childhood leukaemia and the Hippo pathway." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/991/.

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Hypermethylation of CpG islands is one of the many processes that a developing cancer cell may use for the inactivation of tumour suppressor genes. The Sav/Hippo/Warts pathway was originally identified in Drosophila and shown to be responsible for controlling both growth and apoptosis, implying this is a tumour suppressor pathway. This pathway is both evolutionarily and functionally conserved in mammals. Work presented here shows that apart from FAT1 and YAP other pathway members are not epigenetically silenced in common epithelial or haematological cancers. FAT1 and YAP were frequently methyl

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Rounsevell, Ross William Stanley. "Mutational analysis of the mechanical unfolding pathway of TNfn3." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615004.

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Sunami, Yoshiaki. "Molecular analysis of the non-canonical NF-kappaB pathway." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. http://www.theses.fr/2006STR13177.

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On a montré ici que les voies canonique/non-canonique de NF-B ne sont pas indépendantes et qu’un rôle principal de la voie canonique est l’activation des acteurs de la voie non-canonique. La traduction est requise et la stimulation par LPS régule positivement un éventuel intermédiaire dans la signalisation par LPS/CD40 qui supporte l'activation de la voie non-canonique. De plus, la voie non-canonique est constitutivement activée dans les cellules de HL, impliquant la phosphorylation persistante de p100. L'activation transitoire et constitutive de la voie non-canonique implique l'incorporation

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Bennallack, Philip Ross. "Genetic and Biochemical Analysis of the Micrococcin Biosynthetic Pathway." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6182.

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Declining antibiotic discovery and flourishing antibiotic resistance have led to a modern antibiotic crisis which threatens to compromise our ability to treat infectious disease. Consequently, there is significant interest in developing new antibiotics with novel modes of action and chemical properties. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are natural compounds with the appealing attributes of being derived directly from a genetic template while possessing numerous exotic chemical features that contribute to stability and antimicrobial activity. Abundant i

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Singh, P. "Metabolomics and camphor biosynthetic pathway analysis of ocimum killmandscharicum." Thesis(Ph.D.), CSIR - National Chemical Laboratory, Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5833.

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Seeger, Victoria Nell. "Collaborative Retrospective Miscue Analysis : a pathway to self-efficacy in reading." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2163.

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El-Hassi, Mohamed F. "Functional analysis of some yeast genes." Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4767/.

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A series of mutant strains of the yeast Saccharomyces cerevisiae that are sensitive to osmotic stress and also have a defect in vacuolar biogenesis have been isolated (M. Latterich, PhD Thesis 1992). The mutations that cause this pleiotropic phenotype are termed ssv, for salt sensitive vacuolar mutants. Complementation analysis has revealed that ssv mutations fall into one of 18 complementation groups. A MAP kinase related signal transduction pathway, termed the HOG pathway for High Osmolarity Glycerol, has been identified in yeast. This pathway senses osmotic stress and invokes the cellular r

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44

Peifer, Susanne [Verfasser], and Elmar [Akademischer Betreuer] Heinzle. "In-depth analysis of the purine biosynthetic pathway of Corynebacterium glutamicum : from local pathway analysis to global phenotype profiling / Susanne Peifer. Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1052781411/34.

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Peifer, Susanne Verfasser], and Elmar [Akademischer Betreuer] [Heinzle. "In-depth analysis of the purine biosynthetic pathway of Corynebacterium glutamicum : from local pathway analysis to global phenotype profiling / Susanne Peifer. Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-50444.

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Stelios, Pavlidis. "Pathway based microarray analysis based on multi-membership gene regulation." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6968.

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Recent developments in automation and novel experimental techniques have led to the accumulation of vast amounts of biological data and the emergence of numerous databases to store the wealth of information. Consequentially, bioinformatics have drawn considerable attention, accompanied by the development of a plethora of tools for the analysis of biological data. DNA microarrays constitute a prominent example of a high-throughput experimental technique that has required substantial contribution of bioinformatics tools. Following its popularity there is an on-going effort to integrate gene expr

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Hoskin, David W. "Analysis of immunoregulatory pathways in murine pregnancy." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72047.

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Understanding how the antigenically foreign fetus escapes attack by maternal lymphoid cells has long been a goal of reproductive immunologists. The present thesis work analyzes the expression and regulation of maternal immunity to self Ia antigen, as well as to embryonic antigens common to fetal and tumor cells but absent from normal adult somatic tissues. Initial studies revealed that the in vitro proliferative capacity of thymus and bone marrow-derived T cells is enhanced during syngeneic murine pregnancy. Pregnancy was also found to promote the manifestation of autoreactive splenic T cells

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Brodie, Douglas William. "Molecular analysis of T cell costimulatory pathways." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249517.

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49

Chu, Wai Kit. "Genetic analysis of homologous recombination repair pathways." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510942.

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Raza, Sobia. "Modelling and analysis of macrophage activation pathways." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5898.

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Abstract:

Macrophages are present in virtually all tissues and account for approximately 10% of all body mass. Although classically credited as the scavenger cells of innate immune system, ridding a host of pathogenic material and cellular debris though their phagocytic function, macrophages also play a crucial role in embryogenesis, homeostasis, and inflammation. De-regulation of macrophage function is therefore implicated in the progression of many disease states including cancer, arthritis, and atherosclerosis to name just a few. The diverse range of activities of this cell can be attributed to its e

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