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Journal articles on the topic 'Pathway elucidation'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Fairgrieve, Marian, Michael Davis, and Michael J. Gale. "Elucidation of the NLRP3 interactome." Journal of Immunology 196, no. 1_Supplement (2016): 62.7. http://dx.doi.org/10.4049/jimmunol.196.supp.62.7.

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Abstract Upon pathogen detection, the immune system triggers a variety of signaling pathways. Two key pathways are the proinflammatory NLRP3 inflammasome pathway, which activates the proinflammatory cytokines IL-1β and IL-18 via activation of Caspase-1 (CASP1), and the antiviral IFN pathway, which signals through the JAK-STAT pathway to upregulate key IFN-stimulated genes. Importantly, a growing body of evidence demonstrates that crosstalk between these pathways is required to fine tune the host immune response, and the co-regulation between the pathways can be either positive or negative. For

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Zhang, Hongyu, Ran Liu, Tingting Lou, Pei Zhao, and Suying Wang. "Pentostatin Biosynthesis Pathway Elucidation and Its Application." Fermentation 8, no. 9 (2022): 459. http://dx.doi.org/10.3390/fermentation8090459.

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Pentostatin (PNT), a nucleoside antibiotic with a 1,3-diazo ring structure, is distributed in several actinomycetes and fungi species. Its special structure makes PNT possess a wide spectrum of biological and pharmacological properties, such as antibacterial, antitrypanosomal, anticancer, antiviral, herbicidal, insecticidal, and immunomodulatory effects. Because of the promising adenosine deaminase inhibitory activity of PNT, its extensive application in the clinical treatment of malignant tumors has been extensively studied. However, the fermentation level of microbial-derived PNT is low and

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3

Han, Jianing, Emma Parker Miller, and Sijin Li. "Cutting-edge plant natural product pathway elucidation." Current Opinion in Biotechnology 87 (June 2024): 103137. http://dx.doi.org/10.1016/j.copbio.2024.103137.

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Ren, Dongliang, Enjie Diao, Hanxue Hou, and Haizhou Dong. "Degradation and ozonolysis pathway elucidation of deoxynivalenol." Toxicon 174 (January 2020): 13–18. http://dx.doi.org/10.1016/j.toxicon.2019.11.015.

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5

Gonçalves dos Santos, Karen Cristine, Fatima Awwad, Natacha Mérindol, and Isabel Desgagné-Penix. "From pathway to products: Canadian achievements in plant specialized metabolism." Genome 68 (January 1, 2025): 1–23. https://doi.org/10.1139/gen-2024-0099.

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Canada has made significant contributions to the field of plant biochemistry, with numerous researchers actively focusing on elucidating the biosynthetic pathways of plant specialized metabolites and producing these compounds in heterologous systems, such as bacteria, yeast, or other plant species. The review aims to highlight the strengths of Canadian research in this domain over the last three decades. It will describe advances in pathway elucidation, enzyme characterization, and production of enzymes and metabolites in heterologous systems, particularly in the areas of alkaloids, terpenoids

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Kitts, C. L., J. P. Lapointe, V. T. Lam, and R. A. Ludwig. "Elucidation of the complete Azorhizobium nicotinate catabolism pathway." Journal of Bacteriology 174, no. 23 (1992): 7791–97. http://dx.doi.org/10.1128/jb.174.23.7791-7797.1992.

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7

DAUPHIN-VILLEMANT, CHANTAL, CATHERINE BLAIS, and RENE LAFONT. "Towards the Elucidation of the Ecdysteroid Biosynthetic Pathway." Annals of the New York Academy of Sciences 839, no. 1 TRENDS IN COM (1998): 306–10. http://dx.doi.org/10.1111/j.1749-6632.1998.tb10781.x.

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8

Shao, Jie, Yuwei Sun, Haili Liu, and Yong Wang. "Pathway elucidation and engineering of plant-derived diterpenoids." Current Opinion in Biotechnology 69 (June 2021): 10–16. http://dx.doi.org/10.1016/j.copbio.2020.08.007.

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9

Chen, Junmin, Jianyong Chen, and Jingrong Lu. "Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology." Evidence-Based Complementary and Alternative Medicine 2020 (July 14, 2020): 1–8. http://dx.doi.org/10.1155/2020/5354215.

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Oroxylum indicum (O. indicum) is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect of O. indicum and its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds of O. indicum was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential drug targets of O. indicum were identified using PharmMapper database. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichmen

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10

Godden, B., A. S. Ball, P. Helvenstein, A. J. Mccarthy, and M. J. Penninckx. "Towards elucidation of the lignin degradation pathway in actinomycetes." Journal of General Microbiology 138, no. 11 (1992): 2441–48. http://dx.doi.org/10.1099/00221287-138-11-2441.

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11

Roberts, Christopher C., and Chia-en A. Chang. "Ligand Binding Pathway Elucidation for Cryptophane Host–Guest Complexes." Journal of Chemical Theory and Computation 9, no. 4 (2013): 2010–19. http://dx.doi.org/10.1021/ct301023m.

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12

Fiore, Alessia, Luca Dall’Osto, Paul D. Fraser, Roberto Bassi та Giovanni Giuliano. "Elucidation of the β-carotene hydroxylation pathway inArabidopsis thaliana". FEBS Letters 580, № 19 (2006): 4718–22. http://dx.doi.org/10.1016/j.febslet.2006.07.055.

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13

Zhou, Yanqing, Jialin Zhu, Luying Shao, and Mengmeng Guo. "Current advances in acteoside biosynthesis pathway elucidation and biosynthesis." Fitoterapia 142 (April 2020): 104495. http://dx.doi.org/10.1016/j.fitote.2020.104495.

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14

Sugawa, Hikari, and Ryoji Nagai. "Elucidation Of The Pathway For CML Formation From Ribose." Free Radical Biology and Medicine 192 (November 2022): 137. http://dx.doi.org/10.1016/j.freeradbiomed.2022.10.256.

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15

Rohmer, M. "Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution." Pure and Applied Chemistry 75, no. 2-3 (2003): 375–88. http://dx.doi.org/10.1351/pac200375020375.

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A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in the chloroplasts of all phototrophic organisms. It represents an alternative to the well known mevalonate pathway, which is present in animals, fungi, plant cytoplasm, archaebacteria, and some eubacteria. This contribution summarizes key steps of its elucidation and the state-of-the-art knowledge of this biosynthetic pathway, which represents a novel target for antibacterial and antiparasitic drugs.

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Vidya C S and Arehally M Mahlakshmi. "Neuroprotective role of Beta-asarone: A review." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1908–14. http://dx.doi.org/10.26452/ijrps.v12i3.4792.

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Acorus calamus (Acoraceae) also known as sweet flag in Indian traditional medicine is generally used for treatment of various ailments like cough, fever, bronchitis, inflammation, depression, tumours, haemorrhoids, skin diseases, insomnia, hysteria, epilepsy, and loss of memory. Asarone is a chemical compound of the phenylpropanoid class found in plants such as Acorus and Asarum. There are two isomers, α (trans) and β (cis). Alpha-asarone is potentially toxic compared to beta-asarone and hence pharmacological elucidation of beta-asarone is wide. Beta-asarone due to its blood brain barrier cros

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17

Risso, Carla, Stephen J. Van Dien, Amber Orloff, Derek R. Lovley, and Maddalena V. Coppi. "Elucidation of an Alternate Isoleucine Biosynthesis Pathway in Geobacter sulfurreducens." Journal of Bacteriology 190, no. 7 (2008): 2266–74. http://dx.doi.org/10.1128/jb.01841-07.

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ABSTRACT The central metabolic model for Geobacter sulfurreducens included a single pathway for the biosynthesis of isoleucine that was analogous to that of Escherichia coli, in which the isoleucine precursor 2-oxobutanoate is generated from threonine. 13C labeling studies performed in G. sulfurreducens indicated that this pathway accounted for a minor fraction of isoleucine biosynthesis and that the majority of isoleucine was instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway. Genes encoding citramalate synthase (GSU1798), which catalyzes the first dedic

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Puthumadathil, Neethu, Poornendhu Jayasree, K. Santhosh Kumar, K. Madhavan Nampoothiri, Harsha Bajaj, and Kozhinjampara R. Mahendran. "Detecting the structural assembly pathway of human antimicrobial peptide pores at single-channel level." Biomaterials Science 7, no. 8 (2019): 3226–37. http://dx.doi.org/10.1039/c9bm00181f.

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19

Ghisalba, Oreste. "Biosynthesis of Rifamycins (Ansamycins) and Microbial Production of Shikimate Pathway Precursors, Intermediates, and Metabolites." CHIMIA 39, no. 4 (1985): 79. https://doi.org/10.2533/chimia.1985.79.

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Is the elucidation of biosynthetic pathways of academic interest only, or are there enough valuable spin-offs to make biogenetic studies attractive for a research laboratory in a pharmaceutical company? In this short review it is demonstrated how an interdisciplinary approach to the biosynthesis of rifamycins resulted in the formulation of a general biosynthetic pathway for the whole group of ansamycins and related antibiotics. 3-Amino-5-hydroxybenzoic acid, a natural amino acid derived from the shikimate pathway has been identified as the starter unit for ansamycins and related antibiotics. T

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20

Wishart, David S., Carin Li, Ana Marcu, et al. "PathBank: a comprehensive pathway database for model organisms." Nucleic Acids Research 48, no. D1 (2019): D470—D478. http://dx.doi.org/10.1093/nar/gkz861.

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Abstract PathBank (www.pathbank.org) is a new, comprehensive, visually rich pathway database containing more than 110 000 machine-readable pathways found in 10 model organisms (Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Saccharomyces cerevisiae, Escherichia coli and Pseudomonas aeruginosa). PathBank aims to provide a pathway for every protein and a map for every metabolite. This resource is designed specifically to support pathway elucidation and pathway discovery in transcriptomics, proteomics, metabolomics

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21

Yang, Ying, Rie Yatsunami, Ai Ando, et al. "Complete Biosynthetic Pathway of the C50Carotenoid Bacterioruberin from Lycopene in the Extremely Halophilic Archaeon Haloarcula japonica." Journal of Bacteriology 197, no. 9 (2015): 1614–23. http://dx.doi.org/10.1128/jb.02523-14.

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ABSTRACTHaloarcula japonica, an extremely halophilic archaeon that requires high concentrations of NaCl for growth, accumulates the C50carotenoid bacterioruberin (BR). By homology analysis, a gene cluster, includingc0507,c0506, andc0505, was found and predicted to be involved in the synthesis of bacterioruberin. To elucidate the function of the encoded enzymes, we constructedHa. japonicamutants of these genes and analyzed carotenoids produced by the mutants. Our research showed thatc0507,c0506, andc0505encoded a carotenoid 3,4-desaturase (CrtD), a bifunctional lycopene elongase and 1,2-hydrata

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22

Qin, Feng, Lumei Dai, Bin Zhang, et al. "(±)-Corysaxicolaine A: a pair of antitumor enantiomeric alkaloid dimers from Corydalis saxicola." Organic & Biomolecular Chemistry 20, no. 7 (2022): 1396–400. http://dx.doi.org/10.1039/d1ob02334a.

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23

Ahmed, Faruk, Joaquín Ortega-Castro, Antonio Frontera, and Mohammad Hedayetullah Mir. "Semiconducting properties of pyridyl appended linear dicarboxylate based coordination polymers: theoretical prediction via DFT study." Dalton Transactions 50, no. 1 (2021): 270–78. http://dx.doi.org/10.1039/d0dt03868g.

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24

Yan, Jia-Xuan, Qihao Wu, Eric J. N. Helfrich, et al. "Bacillimidazoles A−F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus." Marine Drugs 20, no. 1 (2022): 43. http://dx.doi.org/10.3390/md20010043.

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Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A–F (1–6). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of 1–6. In addition, a plausible biosynthetic pathway to bacillimidazoles is proposed based on isotopic labeling experiments and invokes the highly reactive glycolytic adduct 2,3-butanedione. Combined, the results of structure e

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25

Cornish, Rita M., John R. Roth, and C. Dale Poulter. "Lethal Mutations in the Isoprenoid Pathway of Salmonella enterica." Journal of Bacteriology 188, no. 4 (2006): 1444–50. http://dx.doi.org/10.1128/jb.188.4.1444-1450.2006.

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ABSTRACT Essential isoprenoid compounds are synthesized using the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway in many gram-negative bacteria, some gram-positive bacteria, some apicomplexan parasites, and plant chloroplasts. The alternative mevalonate pathway is found in archaea and eukaryotes, including cytosolic biosynthesis in plants. The existence of orthogonal essential pathways in eukaryotes and bacteria makes the MEP pathway an attractive target for the development of antimicrobial agents. A system is described for identifying mutations in the MEP pathway of Salmonella enterica ser

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26

Gummerlich, Nils, Yuriy Rebets, Constanze Paulus, Josef Zapp, and Andriy Luzhetskyy. "Targeted Genome Mining—From Compound Discovery to Biosynthetic Pathway Elucidation." Microorganisms 8, no. 12 (2020): 2034. http://dx.doi.org/10.3390/microorganisms8122034.

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Natural products are an important source of novel investigational compounds in drug discovery. Especially in the field of antibiotics, Actinobacteria have been proven to be a reliable source for lead structures. The discovery of these natural products with activity- and structure-guided screenings has been impeded by the constant rediscovery of previously identified compounds. Additionally, a large discrepancy between produced natural products and biosynthetic potential in Actinobacteria, including representatives of the order Pseudonocardiales, has been revealed using genome sequencing. To tu

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27

Torrens-Spence, Michael P., Tomáš Pluskal, Fu-Shuang Li, Valentina Carballo, and Jing-Ke Weng. "Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis." Molecular Plant 11, no. 1 (2018): 205–17. http://dx.doi.org/10.1016/j.molp.2017.12.007.

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28

Winterberg, Britta, Stefanie Uhlmann, Uwe Linne, et al. "Elucidation of the complete ferrichrome A biosynthetic pathway inUstilago maydis." Molecular Microbiology 75, no. 5 (2010): 1260–71. http://dx.doi.org/10.1111/j.1365-2958.2010.07048.x.

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29

Liu, Qing, David Manzano, Nikola Tanić, et al. "Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway." Metabolic Engineering 23 (May 2014): 145–53. http://dx.doi.org/10.1016/j.ymben.2014.03.005.

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30

Creek, Darren J., Achuthanunni Chokkathukalam, Andris Jankevics, Karl E. V. Burgess, Rainer Breitling, and Michael P. Barrett. "Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation." Analytical Chemistry 84, no. 20 (2012): 8442–47. http://dx.doi.org/10.1021/ac3018795.

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31

Kresge, Nicole, Robert D. Simoni, and Robert L. Hill. "Otto Fritz Meyerhof and the Elucidation of the Glycolytic Pathway." Journal of Biological Chemistry 280, no. 4 (2005): e3. http://dx.doi.org/10.1016/s0021-9258(20)76366-0.

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32

Barry, Robert J., Elise Bowman, Michael McQueney, and Debra Dunaway-Mariano. "Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis." Biochemical and Biophysical Research Communications 153, no. 1 (1988): 177–82. http://dx.doi.org/10.1016/s0006-291x(88)81205-1.

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33

Salido-Vallejo, R., G. Garnacho-Saucedo, and A. Vélez. "Elucidation of the mTOR Pathway and Therapeutic Applications in Dermatology." Actas Dermo-Sifiliográficas (English Edition) 107, no. 5 (2016): 379–90. http://dx.doi.org/10.1016/j.adengl.2016.03.001.

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34

Qin, Kezhen, Fang Liu, Caibin Zhang, Rui Deng, Alisdair R. Fernie, and Youjun Zhang. "Systems and synthetic biology for plant natural product pathway elucidation." Cell Reports 44, no. 6 (2025): 115715. https://doi.org/10.1016/j.celrep.2025.115715.

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35

Akl, Maher Monir, and Amr Ahmed. "Tumor Cytobiology of IGF-1R in Breast Tumor Activation and Propagation; And the Role of Celecoxib in its Inhibition." Medicine & Community Health Archives 2, no. 10 (2024): 189–203. http://dx.doi.org/10.23958/mcha/vol02/i10/40.

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The Insulin-like Growth Factor 1 Receptor (IGF-1R) stands as a central orchestrator in cellular signaling, governing pivotal processes encompassing growth, proliferation, and differentiation. Its aberrant activation is intricately intertwined with the pathogenesis and progression of breast cancer, a heterogeneous disease presenting formidable clinical challenges. Amidst the burgeoning landscape of therapeutic interventions, Celecoxib, a nonsteroidal anti-inflammatory drug (NSAID), has emerged as a promising candidate for targeting the dysregulated IGF-1R pathway. This review delineates the int

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36

Liang, Lifan, Kunju Zhu, Junyan Tao, and Songjian Lu. "ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network." PLOS Computational Biology 17, no. 4 (2021): e1008792. http://dx.doi.org/10.1371/journal.pcbi.1008792.

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Pathway level understanding of cancer plays a key role in precision oncology. However, the current amount of high-throughput data cannot support the elucidation of full pathway topology. In this study, instead of directly learning the pathway network, we adapted the probabilistic OR gate to model the modular structure of pathways and regulon. The resulting model, OR-gate Network (ORN), can simultaneously infer pathway modules of somatic alterations, patient-specific pathway dysregulation status, and downstream regulon. In a trained ORN, the differentially expressed genes (DEGs) in each tumour

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37

Liu, Chuan, Fang-Fang Fan, Xuan-Hao Li, Wen-Xiang Wang, Ya Tu, and Yi Zhang. "Elucidation of the mechanisms underlying the anticholecystitis effect of the Tibetan medicine “Dida” using Network pharmacology." Tropical Journal of Pharmaceutical Research 19, no. 9 (2020): 1953–61. http://dx.doi.org/10.4314/tjpr.v19i9.22.

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Purpose: To study the mechanism involved in the anti-cholecystitis effect the Tibetan medicine “Dida”, using network pharmacology-integrated molecular docking simulationsMethods: In this investigation, the bioactive compounds of Dida were collected, network pharmacology methods to predict their targets, and networks were constructed through GO and KEGG pathway analyses. The potential binding between the bioactive compounds and the targets were demonstrated using molecular docking simulations.Results: A total of 12 bioactive compounds and 50 key targets of Dida were identified. Two networks, na

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Kundu, Debasree, Chinmay Hazra, and Ambalal Chaudhari. "Biodegradation of 2,4-dinitrotoluene with Rhodococcus pyridinivorans NT2: characteristics, kinetic modeling, physiological responses and metabolic pathway." RSC Advances 5, no. 49 (2015): 38818–29. http://dx.doi.org/10.1039/c5ra02450a.

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He, Zhongqi, and Jim C. Spain. "Reactions Involved in the Lower Pathway for Degradation of 4-Nitrotoluene by Mycobacterium Strain HL 4-NT-1." Applied and Environmental Microbiology 66, no. 7 (2000): 3010–15. http://dx.doi.org/10.1128/aem.66.7.3010-3015.2000.

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ABSTRACT In spite of the variety of initial reactions, the aerobic biodegradation of aromatic compounds generally yields dihydroxy intermediates for ring cleavage. Recent investigation of the degradation of nitroaromatic compounds revealed that some nitroaromatic compounds are initially converted to 2-aminophenol rather than dihydroxy intermediates by a number of microorganisms. The complete pathway for the metabolism of 2-aminophenol during the degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45 has been elucidated previously. The pathway is parallel to the catechol extradiol ri

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40

Zeng, Fangfang, Haixin Jiang, Haoqi Xu, Ruotong Shen, and Dianxuan Wang. "Comparative Transcriptomics Analysis Reveals Rusty Grain Beetle’s Aggregation Pheromone Biosynthesis Mechanism in Response to Starvation." Insects 15, no. 2 (2024): 137. http://dx.doi.org/10.3390/insects15020137.

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Pheromones are the basis of insect aggregation, mating, and other behaviors. Cucujoid grain beetles produce macrocyclic lactones as aggregation pheromones, yet research on their biosynthesis at the molecular level remains limited. The rusty grain beetle, C. ferrugineus, is an important economic species in China. Although two aggregation pheromone components have been identified, their suspected biosynthesis via the MVA pathway and the FAS pathway lacks molecular elucidation. Previous evidence supports that starvation affects the production of aggregation pheromones. Therefore, we constructed c

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Čikoš, Ana, Snježana Dragojević, and Adrijana Kubiček. "Degradation products of azetidine core G334089 – Isolation, structure elucidation and pathway." Journal of Pharmaceutical and Biomedical Analysis 203 (September 2021): 114232. http://dx.doi.org/10.1016/j.jpba.2021.114232.

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42

Pu, Xiang, Jia Li, Ziang Guo, et al. "Structure-based identification and pathway elucidation of flavonoids in Camptotheca acuminate." Synthetic and Systems Biotechnology 7, no. 2 (2022): 824–36. http://dx.doi.org/10.1016/j.synbio.2022.03.007.

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Jamadar, David A., Ella A. Kazerooni, and Ronald B. Hirschl. "Case Report. Pneumomediastinum: Elucidation of the Anatomic Pathway by Liquid Ventilation." Journal of Computer Assisted Tomography 20, no. 2 (1996): 309–11. http://dx.doi.org/10.1097/00004728-199603000-00027.

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Kajiura, Takayuki. "Elucidation of Biosynthetic Pathway of Hibarimicins, v-src Tyrosine Kinase Inhibitors." Actinomycetologica 18, no. 1 (2004): 22–25. http://dx.doi.org/10.3209/saj.18_22.

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45

Young, Jeanette, D. Cole Stevens, Rory Carmichael, et al. "Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM-Dependent Methylations." Journal of Natural Products 76, no. 12 (2013): 2269–76. http://dx.doi.org/10.1021/np400629v.

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46

Jiang, Luhua, Qiwen Tang, Jing Liu, and Gongquan Sun. "Elucidation of oxygen reduction reaction pathway on carbon-supported manganese oxides." Chinese Journal of Catalysis 36, no. 2 (2015): 175–80. http://dx.doi.org/10.1016/s1872-2067(14)60249-7.

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47

Beckett, Michael A., and Inez Hua. "Elucidation of the 1,4-Dioxane Decomposition Pathway at Discrete Ultrasonic Frequencies." Environmental Science & Technology 34, no. 18 (2000): 3944–53. http://dx.doi.org/10.1021/es000928r.

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48

Moonen, Mariëlle J. H., Nanne M. Kamerbeek, Adrie H. Westphal, et al. "Elucidation of the 4-Hydroxyacetophenone Catabolic Pathway in Pseudomonas fluorescens ACB." Journal of Bacteriology 190, no. 15 (2008): 5190–98. http://dx.doi.org/10.1128/jb.01944-07.

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ABSTRACT The catabolism of 4-hydroxyacetophenone in Pseudomonas fluorescens ACB is known to proceed through the intermediate formation of hydroquinone. Here, we provide evidence that hydroquinone is further degraded through 4-hydroxymuconic semialdehyde and maleylacetate to β-ketoadipate. The P. fluorescens ACB genes involved in 4-hydroxyacetophenone utilization were cloned and characterized. Sequence analysis of a 15-kb DNA fragment showed the presence of 14 open reading frames containing a gene cluster (hapCDEFGHIBA) of which at least four encoded enzymes are involved in 4-hydroxyacetophenon

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49

Mo, Xuhua, Chun Gui, and Qingji Wang. "Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathway." Bioorganic & Medicinal Chemistry Letters 27, no. 18 (2017): 4431–35. http://dx.doi.org/10.1016/j.bmcl.2017.08.010.

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50

De Luca, Vincenzo, Vonny Salim, Antje Thamm, Sayaka Atsumi Masada, and Fang Yu. "Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation." Current Opinion in Plant Biology 19 (June 2014): 35–42. http://dx.doi.org/10.1016/j.pbi.2014.03.006.

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