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Dissertations / Theses on the topic 'Pathways'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Konrad, Attila. "Investigation of Pathway Analysis Tools for mapping omics data to pathways." Thesis, Malmö högskola, Fakulteten för teknik och samhälle (TS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20843.

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Detta examensarbete granskar analysverktyg ur ett tvärvetenskapligt perspektiv. Det finns en hel del olika analysverktyg idag som analyserar specifika typer av omik data och därför undersöker vi hur många det finns samt vad de kan göra. Genom att definiera ett antal specifika krav såsom hur många typer av omik data den kan hantera, noggrannhet av verktygets analys så kan man se vilka som är mest lämpliga analysverktygen när det gäller kartläggning av omik data. Resultaten visar att det idag inte finns analysverktyg som uppfyller de specifikt angivna kraven eller huvudsyftet genom testning av p

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2

Soh, Donny. "Understanding pathways." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6399.

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The challenge with todays microarray experiments is to infer biological conclusions from them. There are two crucial difficulties to be surmounted in this challenge:(1) A lack of suitable biological repository that can be easily integrated into computational algorithms. (2) Contemporary algorithms used to analyze microarray data are unable to draw consistent biological results from diverse datasets of the same disease. To deal with the first difficulty, we believe a core database that unifies available biological repositories is important. Towards this end, we create a unified biological datab

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3

Gupta, Apoorv. "Dynamic regulation of bacterial metabolic pathways using autonomous, pathway-independent control strategies." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112511.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 86-91).<br>Metabolic engineering efforts have so far focused on strain optimization through careful metabolic modeling and tinkering with host genomes, through gene knockouts or knockins, to direct flux in desired channels. These efforts have borne fruit with the development of large manufacturing processes for numerous chemicals. The next challenge for metabolic engineering, however, lies in tackling issues as

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4

Burwitz, Martin. "Integrated Clinical Pathways." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226773.

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Against the background of increasing multidisciplinarity as well as the focus on quality, transparency and economic efficiency of medical services, clinical pathways (CPs) have been established as a promising tool at the organizational level in recent years. They are primarily intended to ensure an adequate description of the care processes and to manage the balance between best treatment practice and economic viability. CPs standardize the internal care services by explicating the institution-specific knowledge with regard to recommendations for action, service portfolio, organizational struc

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5

Barrett, Susan, and N/A. "Pathways to Detention." Griffith University. School of Criminology and Criminal Justice, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070824.112806.

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This research utilised a range of deterministic and stochastic analyses to establish whether Queensland's juvenile justice system processes Aboriginal and non-Aboriginal young male offenders differently. The impetus for this research stemmed from the continued high rates of Aboriginal over-representation within Australia's criminal justice system, despite diversionary measures to reduce such over-representation, and a commitment by the Queensland Government to reduce by 50% the number of Aboriginal peoples in custody by the year 2011. There are two competing hypotheses concerning the cause of

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6

Dhillon, Ravinder. "Diagnostic imaging pathways." University of Western Australia. School of Medicine and Pharmacology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0126.

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[Truncated abstract] Hypothesis: There is deficiency in the evidence base and scientific underpinning of existing diagnostic imaging pathways (DIP) for diagnostic endpoints. Objective: a) To carry out systematic review of literature in relation to use of diagnostic imaging tests for diagnosis and investigation of 78 common clinical problems, b) To identify deficiencies and controversies in existing diagnostic imaging pathways, and to develop a new set of consensus based pathways for diagnostic imaging (DIP) supported by evidence as an education and decision support tool for hospital based doct

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7

Dalgleish, Alison. "Pathways to principalship." AUT University, 2010. http://hdl.handle.net/10292/935.

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A qualitative descriptive approach was undertaken to research what was available within the areas of advice and guidance for potential principals who wish to achieve the position of principal at secondary schools in Aotearoa New Zealand. The literature review for this study uncovered very little in the way of New Zealand-based professional advice and guidance for potential principals, despite there being some leadership development programmes such as the Principal Preparation Programmes for Aspiring Principals (University of Auckland, Centre for Educational Leadership). However, the internatio

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8

Al, Hashemi Hamed. "Pathways to diversification." Thesis, Cranfield University, 2016. http://dspace.lib.cranfield.ac.uk/handle/1826/11694.

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A fundamental research question in regional economic development, is why some regions are able to diversify into new products and industries, while others continue to face challenges in diversification? This doctorate research explores the different pathways to diversification. It follows the three-stage modular structure of DBA for Cranfield School of Management. This thesis consists of a systematic literature review, a single qualitative case study on UAE, and a research synthesis of published cases on Singapore, Norway and UAE. The linking document provides a summary of the three projects a

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9

Dhillon, Ravinder. "Diagnostic imaging pathways /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0126.

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10

Barrett, Susan. "Pathways to Detention." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/366448.

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This research utilised a range of deterministic and stochastic analyses to establish whether Queensland's juvenile justice system processes Aboriginal and non-Aboriginal young male offenders differently. The impetus for this research stemmed from the continued high rates of Aboriginal over-representation within Australia's criminal justice system, despite diversionary measures to reduce such over-representation, and a commitment by the Queensland Government to reduce by 50% the number of Aboriginal peoples in custody by the year 2011. There are two competing hypotheses concerning the cause of

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11

Gonska, Nathalie. "Proton pathways in energy conversion : K-pathway analogs in O2- and NO-reductases." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147267.

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Oxygen and nitric oxide reductases are enzymes found in aerobic and anaerobic respiration, respectively. Both enzyme groups belong to the superfamily of Heme-Copper Oxidases, which is further divided into several subgroups: oxygen-reducing enzymes into A-, B- and C-type and nitric oxide reductases into qNORs and cNORs. Oxygen reducing enzymes use the energy released from oxygen reduction to take up electrons and protons from different sides of the membrane. Additionally, protons are pumped. These processes produce a membrane potential, which is used by the ATP-synthase to produce ATP, the univ

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12

Mailavaram, Sravanthi. "Database for the Study of Biological Pathways, with Wnt Signaling Pathway Use Case." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1227118211.

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13

Yang, Bo. "Biliary glutathione transport pathways." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/MQ52967.pdf.

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14

Lauckner, Jane Elizabeth. "Cannabinoid receptor signaling pathways /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10646.

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15

Goldberg, Lydia. "Videoconferencing pathways to interaction." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22590.

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The rapid convergence of technologies of communication into a multimedia environment taking place over the last decade has created a new interest in the possibilities offered by videoconferencing systems. We are thus beginning to see the expansion of the potential for various levels of human interaction mediated by video in both business and educational domains. Through the support of the technologically mediated environment, people now have the capability to travel across time and space, meeting with other individuals, seemingly as if face-to-face. The purpose of this thesis is to explore mor

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16

Bhargava, Prerna. "Immunomodulatory Pathways and Metabolism." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10696.

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Energy metabolism plays a vital role in normal physiology, adaptive responses and host defense mechanisms. Research throughout the last decade has shown evidence that immune pathways communicate with metabolic pathways to alter the metabolic status in response to physiological or pathological signals. In this thesis, I will explore how immunomodulatory molecules affect metabolic homeostasis and conversely, how metabolic sensing pathways modulate immune responses. The first part my work utilizes an immunomodulatory sugar motif to determine mechanisms by which immune cells influence metabolism.

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17

Gower, D. M. "Pathways to understanding science." Thesis, University of East Anglia, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377746.

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18

Trygubenko, Semen A. "Pathways and energy landscapes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613856.

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19

Taylor, Sarah Cecelia Ferguson. "Pathways to dropping out." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-06062008-144845/.

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20

Satriano, Joseph Anthony. "Interregulation of Arginine pathways /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9952662.

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21

Pagan, Candida. "Pathways to new understanding." Thesis, University of Iowa, 2015. https://ir.uiowa.edu/etd/1717.

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The conceptual foundation for my creative thesis work is based in research into the development of science, particularly the field of cosmology, and its related visual vocabulary. Three interrelated projects encompass my interests in unique artists' books and variable editions, research based projects, codified presentation of data, and universal interconnectedness, or oneness in all things, that was at the heart of medieval cosmology and is embraced by some 21st century subcultures. The thematic timeline of the artwork spans developments in the Early Middle Ages related to astronomy and cosmo

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22

Wolfenden, Kristen Marie. "Characterisation of the metabolome of Mycobacterium tuberculosis to identify new pathways and pathway holes." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/5971.

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Includes abstract.<br>Includes bibliographical references.<br>Due to high incidence rates and the development of new drug-resistant or multidrug-resistant strains of TB, the development of new medicines and treatments for tuberculosis is a necessity. In order to develop these drugs, Mycobacterium tuberculosis (Mtb) needs to be studied more completely; this study performs a characterisation of the metabolome of Mtb and comparison across the phylogenetic profile to identify notable pathways.

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23

Fraser, Sasha. "Development of Dual-Pathway Inhibitors of Raf/MEK/ERK and PI3K/Akt Signaling Pathways." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2619.

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In the present study, we designed a new chemical template that contains an oxindole moiety as potential dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. The design hypothesis is to evaluate whether the oxindole ring system will approximately orient functional groups in a similar manner to the thiazolidinedione moiety, and thus maintain biological activity as dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. Furthermore, the oxindole ring will provide the flexibility to allow the introduction of various substituents on the oxindole moiety, th

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24

Osmanovic, Nermin. "The Pathways of Brand Love : Pathways to brand love out of a consumer perspective." Thesis, Linnéuniversitetet, Institutionen för marknadsföring (MF), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-100299.

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AbstractBrand love has become an increasingly interesting area of research for academics and marketing practitioners alike, as it has shown to drive consumer behaviours such as brand loyalty, positive word-of-mouth and negative information resistance (Batra et al., 2012). However, the focus has primarily been on brand love as a concept and how it drives consumer behaviour from a company perspective, and to a lesser extent on the antecedent pathways that lead to it from a consumer perspective. Based on extant research concerning brand love and its antecedents, this study tries to shed more ligh

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25

Svensson, Emil. "Parameter estimation of biological pathways." Thesis, Linköping University, Department of Electrical Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8430.

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<p>To determine parameter values for models of reactions in the human body, like the glycolysis, good methods of parameter estimation are needed. Those models are often non-linear and estimation of the parameters can be very time consuming if it is possible at all. The goal of this work is to test different methods to improve the calculation speed of the parameter estimation of an example system. If the parameter estimation speed for the example system can be improved it is likely that the method could also be useful for systems similar to the example system.</p><p>One approach to improve the

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26

Hauck, Stefanie. "Neuroprotective pathways in the retina." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-45535.

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27

Tadros, Amir. "Novel pathways in microvascular signalling." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29504.

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The regulation of microvascular survival impacts both developmental remodelling of the vasculature, and various pathologies. The aim of this thesis was to examine the role of a recently identified A20 binding inhibitor of NF-kB, a zinc finger protein termed ABIN-2 in endothelial protection. More specifically, looking at its effects on inflammation and apoptosis in endothelia both at the cellular level and in vivo. The involvement of ABIN-2 in the Tie2 receptor pathway was also examined. Tie2 is an endothelial receptor essential for blood vessel formation and promotes endothelial survival. A tr

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28

Szmajda, Brett A. "Subcortical pathways for colour vision /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00003165.

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Thesis (Ph.D.)--University of Melbourne, The National Vision Research Institute of Australia and Dept. of Optometry & Vision Sciences, 2007.<br>Typescript. Includes bibliographical references (leaves 95-111).

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29

Priestley, Alistair James. "Signal transduction pathways in plants." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250567.

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30

Raval, Raju R. "Hypoxia-mediated pathways in cancer." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433331.

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31

Krishna, Ritesh V. "From gene-expressions to pathways." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3159/.

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Rapid advancements in experimental techniques have benefited molecular biology in many ways. The experiments once considered impossible due to the lack of resources can now be performed with relative ease in an acceptable time-span; monitoring simultaneous expressions of thousands of genes at a given time point is one of them. Microarray technology is the most popular method in biological sciences to observe the simultaneous expression levels of a large number of genes. The large amount of data produced by a microarray experiment requires considerable computational analysis before some biologi

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32

Sarangi, Sudhanshu. "Psychological pathways in militant Jihad." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548762.

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33

Kotwaliwale, Ashwin. "Frameworks for Modeling MAPK Pathways." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520778.

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34

Flavell, Charlotte Rachael. "Nociceptive processing in cerebellar pathways." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505762.

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Noxious stimuli have a profound influence on motor behaviour, but there is a paucity of information regarding how somatosensory information is transformed into a motor output. The cerebellum is the largest sensorimotor control structure within the brain and previous electrophysiological studies have demonstrated that climbing fibres, one of its major sources of afferent input, are activated in response to a noxious pinch stimulus. This thesis investigates the anatomical pathways by which nociceptive information may reach the cerebellum, with a particular focus upon the olivo-cerebellar system,

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35

Goddard, Maria Nadia. "Manipulating biochemical pathways in rice." Thesis, University of Nottingham, 2004. http://eprints.nottingham.ac.uk/28567/.

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The brown planthopper, Nilaparvata lugens, is a pest of rice in tropical regions. Its direct feeding results in loss in yield and plant death ("hopper bum"). Several compounds that stimulate insect attraction have been detected in rice plants colonised by N. lugens, including 1,2-dimethoxybenzene or veratrole. Electro-physiological studies and highresolution gas chromatography have identified veratrole as an attractant of N. lugens. Veratrole is a product of salicylic acid, a derivative of the phenyl propanoid pathway. Salicylic acid is decarboxylated to catechol, a step which is encoded by sa

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36

Dzyabura, Vasily. "Pathways to a Metallic Hydrogen." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10737.

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The primary subject of this thesis is the study of warm dense hydrogen by means of pulsed laser heating in the pressure region 1 to 2 Mbar and temperatures above the melting line, where a liquid-liquid phase transition from the insulating molecular fluid to a conducting atomic hydrogen fluid, so called plasma phase transition (PPT), was predicted to take place. The first evidence of the PPT under static compression is reported. The observations are in agreement with the negative slope phase line predicted by ab initio methods.<br>Physics

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37

Daae, Elisabeth Bull. "Mathematical modelling of biochemical pathways." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327023.

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38

Ismail, Sabariah. "Drug conjugation pathways in malaria." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386782.

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39

Nowers, Michael. "Violent suicide : pathways to prevention." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393881.

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40

SILVA, SÉRGIO FERREIRA. "ANALYTIC GEOMETRY: PATHWAYS TO LEARNING." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2015. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=25720@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>A presente pesquisa tem como tema o processo de ensino e aprendizagem de geometria analítica, assunto no qual os alunos do ensino médio têm apresentado dificuldades. Por isto se faz necessário que o professor utilize um maior número de ferramentas pedagógicas, explorando os caminhos algébrico e geométrico para resolução de problemas. O objetivo deste estudo é propor caminhos para o ensino da geometria analítica tendo como base três eixos norteadores: A história das geometrias,

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41

Laganis, C. R. "Pathways to unusual sensory perceptions." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008832/.

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42

Calvo, Sarah E. "Mitochondrial parts, pathways, and pathogenesis." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54449.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In title on title page, the word "Mitochondrial" is spelled "Mitochondial."<br>Mitochondria are cellular compartments that perform essential roles in energy metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore the function of mitochondria in health and in disease, it is

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43

Went, Heather Michelle. "Protein folding and assembly pathways." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620463.

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44

Dandreaux, Danielle. "Developmental Pathways To Conduct Problems." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/566.

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This study tests the predictions made by several causal theories proposing different etiologies for childhood-onset and adolescent-onset conduct problems. It investigates a variety of causal factors proven to be important for the development of antisocial behaviors, specifically neuropsychological/cognitive deficits, temperamental vulnerabilities, dysfunctional parenting, deviant peers, and rebelliousness. Current theories generally agree that the early onset pathway is distinguished by interactions between a child with a difficult temperament and dysfunctional parent-child interactions.

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45

Crane, Maureen. "Pathways to later life homelessness." Thesis, University of Sheffield, 1997. http://etheses.whiterose.ac.uk/15081/.

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The aim of this doctoral thesis is to increase the understanding of the causes of homelessness in later life, by identifying how antecedents, states and events interact and both trigger and contribute to homelessness, and the processes and pathways involved in the transition to homelessness. Using present theories, concepts and empirical evidence as a foundation, the thesis is largely informed by an intensive ethnographic field study which lasted for 15 months and was carried out in London, Sheffield, Leeds and Manchester. It involved 225 respondents over the age of 55 years, the majority of w

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van, den Heuvel Daniela Brigitte. "Precipitation pathways of amorphous silica." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13428/.

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Amorphous silica is one of the most common phases to precipitate from geothermal fluids. It precipitates by self-assembly of monomeric silica (H4SiO4) via heterogeneous and homogeneous nucleation and subsequent growth of nuclei by addition of dissolved silica. The mechanism and the factors controlling the individual steps of silica precipitation have been studied in numerous laboratory experiments over the last decades and are, despite their complexity, well understood. However, due to the higher complexity of natural geothermal fluids (e.g high fluid flow rates, microbial activity or complex

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47

McArthur, George Howard IV. "Orthogonal Expression of Metabolic Pathways." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3087.

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Microbial metabolism can be tailored to meet human specifications, but the degree to which these living systems can be repurposed is still unknown. Artificial biological control strategies are being developed with the goal of enabling the predictable implementation of novel biological functions (e.g., engineered metabolism). This dissertation project contributes genetic tools useful for modulating gene expression levels (extending promoters with UP elements) and isolating transcription and translation of engineered DNA from the endogenous cellular network (expression by orthogonal cellular mac

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48

Dean, Lauren Rachael. "Neural pathways of movement fractionation." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2812.

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Stroke is a common neurological event which often results in motor deficits of the hand and arm. The reticulospinal tract (RST) may partly underlie residual hand and arm movement ability after a stroke but remains poorly characterised. A greater understanding of the RST could inform work to improve motor recovery. Additionally, the development of non-invasive methods of probing the RST in humans should allow comparison of the characteristics of the RST across species. It has been suggested that the RST is involved in mediating muscle responses to auditory startle, experimentally known as the S

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49

Parsons, Brenda Dake. "Alternative pathways to the classroom /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/parsonsb/brendaparsons.pdf.

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50

Hosking, Catherine Rose. "Signalling pathways downstream of cadherin." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445587/.

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Formation of cadherin-based adhesive structures at sites of cell-cell contact leads to activation of several signalling pathways inside the cell. In order to examine the molecular mechanisms involved in these pathways, my project focused on two binding partners of cadherin, pi20 catenin and Hakai. pi20 catenin (pi20) is an Armadillo family member, which binds to the cytoplasmic tail of cadherins at sites of cell-cell contact. It has been implicated in regulation of cell- cell adhesion by modulating cadherin trafficking, and also in the regulation of actin dynamics through its association with

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