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1

Cheston, H., E. Miller, and S. Mufti. "120 Improving Delirium Recognition and Management Through In-Situ Simulation." Age and Ageing 50, Supplement_1 (2021): i12—i42. http://dx.doi.org/10.1093/ageing/afab030.81.

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Abstract Introduction Delirium is a common condition that is often associated with increased morbidity and mortality, longer hospital admission, and discharge to a residential or nursing home. By improving our ability to recognise and manage these patients we can intervene early to help reduce the likelihood of these outcomes. Method We organised several in-situ simulation scenarios with junior staff working on the Elderly Care Unit. The research team designed a scenario to re-create a typical delirious patient on the ward. Participants had to recognise the patient was delirious and instigate
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Emond, M., A. Nadeau, V. Boucher, et al. "MP11: Underreport of incident delirium in elderly patients treated in the emergency department." CJEM 20, S1 (2018): S44. http://dx.doi.org/10.1017/cem.2018.165.

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Introduction: It is documented that physicians and nurses fail to detect delirium in more than half of cases from various clinical settings, which could have serious consequences for seniors and for our health care system. The present study aimed to describe the rate of documented incident delirium in 5 Canadian Emergency departments (ED) by health professionals (HP). Methods: This study is part of the multicenter prospective cohort INDEED study. Patients aged 65 years old, initially free of delirium with an ED stay 8hours were followed up to 24h after ward admission. Delirium status was asses
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Émond, M., P. Voyer, R. Daoust, et al. "LO022: Incidence and impact measurement of delirium induced by ED stay - INDEED." CJEM 18, S1 (2016): S37—S38. http://dx.doi.org/10.1017/cem.2016.59.

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Introduction: Delirium is a dreadful complication in seniors’ acute care. Many studies are available on the incidence of delirium, however ED-induced delirium is far less studied. We aim to evaluate the incidence and impact of ED-induced delirium among older non-delirious admitted ED patients who have prolonged ED stays (≥ 8 hours). Methods: This prospective INDEED study phase 1 included patients recruited from 4 Canadian EDs. Inclusion criteria: 1) Patients aged 65 and over; 2) ED stay ≥ 8 hours; 3) Patient is admitted to the hospital; 4) Patient is non-delirious upon arrival and at the end o
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Woodward, Jennifer, and Tru Byrnes. "A Delirium Risk Stratification Tool and Interdisciplinary Rounds to Prevent Delirium in Hospitalized Older Adults." Innovation in Aging 5, Supplement_1 (2021): 593. http://dx.doi.org/10.1093/geroni/igab046.2279.

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Abstract Delirium is a disturbance of attention accompanied by a change in baseline cognition that is commonly seen in acute care settings, and effects up to 80% of ICU patients. The development of delirium has adverse effects on patient outcomes and high health care costs. Of patients aged 65+ admitted to our hospital in 2019, non-delirious patients had a five-day length of stay (LOS) compared to a 10-14 days LOS in delirious patients. A five days LOS increase adds an additional $ 8,325 per patient for an extra annual cost of 15 million dollars. Additionally, delirium is often not recognized.
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Stevens, Lee E., Gregory M. de Moore, and Judy M. Simpson. "Delirium in Hospital: Does it Increase Length of Stay?" Australian & New Zealand Journal of Psychiatry 32, no. 6 (1998): 805–8. http://dx.doi.org/10.3109/00048679809073869.

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Objective: To determine the effect of delirium, as a comorbid diagnosis in hospitalised patients, on patient length of stay (LOS). Method: Prospective study comparing LOS of delirious patients with controls matched by age, gender, principal diagnosis and date of admission. Medical and surgical inpatients of Westmead Hospital with delirium were identified from a Consultation Liaison (CL) psychiatry database and were matched with controls from the hospital medical records. Results: Delirious patient LOS was found to be significantly longer (2.2-fold; 95% confidence interval 1.5-3.3) than matched
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Hamidović, J., L. Dostović Hamidović, S. Haskic, E. Prljača, A. Brigić, and M. Mešanović. "Etiology and pharmacological treatment of delirious syndrome." European Psychiatry 66, S1 (2023): S380. http://dx.doi.org/10.1192/j.eurpsy.2023.822.

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IntroductionPatients in psychiatric department, especially in the intensive care unit, often develop delirium syndrome, which leads to a high risk of morbidity and mortality. The etiology is multifactorial. The most common causes are alcoholism and dementia. Pharmacological treatment of delirious syndrome is the most important part of the treatment, which includes various psychopharmaceuticals that are effective both in the treatment of delirium and in improving cognitive functions. Haloperidol is the drug of first choice and from atypical antipsychotics, the most commonly used are risperidone
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Ryan, Sophia L., and Eyal Y. Kimchi. "Evaluation and Management of Delirium." Seminars in Neurology 41, no. 05 (2021): 572–87. http://dx.doi.org/10.1055/s-0041-1733791.

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AbstractDelirium, sometimes referred to as encephalopathy, is an acute confusional state that is both common in hospitalized patients and associated with poor outcomes. For patients, families, and caregivers, delirium can be a traumatic experience. While delirium is one of the most common diagnoses encountered by the consulting neurologist, the majority of the time it will have been previously unrecognized as such by the care team. Neurologic syndromes such as dementia or aphasia can either be misdiagnosed as delirium or may coexist with it, necessitating careful neurologic assessment. Once th
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8

McGee, Scott B., Claudia A. Orengo, Mark E. Kunik, Victor A. Molinari, and Richard H. Workman. "Delirium in Geropsychiatric Patients: Patient Characteristics and Treatment Outcomes." Journal of Geriatric Psychiatry and Neurology 10, no. 1 (1997): 7–10. http://dx.doi.org/10.1177/089198879701000102.

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The authors examined the effect of hospitalization on cognitive and behavioral symptoms in delirious elderly patients with and without dementia. Forty-four (13%) of the patients admitted to a Veterans Affairs Medical Center geropsychiatric unit were diagnosed with delirium and were administered the Mini-Mental State Examination, the Hamilton Depression Rating Scale, the Brief Psychiatric Rating Scale (BPRS), the Rating Scale for Side Effects, and the Cohen-Mansfield Agitation Inventory. The total sample significantly improved on all measures. When patients with delirium were divided into subgr
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Ragheb, Jacqueline, Amy McKinney, Mackenzie Zierau, et al. "Delirium and neuropsychological outcomes in critically Ill patients with COVID-19: a cohort study." BMJ Open 11, no. 9 (2021): e050045. http://dx.doi.org/10.1136/bmjopen-2021-050045.

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ObjectiveTo characterise the clinical course of delirium for patients with COVID-19 in the intensive care unit, including postdischarge neuropsychological outcomes.DesignRetrospective chart review and prospective survey study.SettingIntensive care units, large academic tertiary-care centre (USA).ParticipantsPatients (n=148) with COVID-19 admitted to an intensive care unit at Michigan Medicine between 1 March 2020 and 31 May 2020 were eligible for inclusion.Primary and secondary outcome measuresDelirium was the primary outcome, assessed via validated chart review method. Secondary outcomes incl
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Tomczyk, Karolina, Karolina Jurasz, Natalia Chojnacka, et al. "Hospital Hallucinosis - where to look for the cause of the delirious syndrome in a geriatric patient and what management to implement." Journal of Education, Health and Sport 53 (January 17, 2024): 102–25. http://dx.doi.org/10.12775/jehs.2024.53.008.

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Delirium syndrome is a serious, and often underestimated, problem arising in elderly patients. The number of accurate diagnoses of this acute condition is significantly lower than actuall present. This is often due to the attribution of its symptoms to the underlying disease. Delirium syndrome, by leading to perceptual disturbances in the patient, impairs his functioning and threatens health and even life of a patient. The pathophysiology of the onset of delirium is not well understood, with many factors influencing its development. Those directly related to the patient (predisposing), as well
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Fairfield, Catherine L., Anne M. Finucane, and Juliet A. Spiller. "15 Triggers for the pharmacological management of delirium in palliative care: a mixed methods study." BMJ Supportive & Palliative Care 8, no. 3 (2018): 365.2–365. http://dx.doi.org/10.1136/bmjspcare-2018-mariecurie.15.

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IntroductionDelirium is a serious neurocognitive disorder with a high prevalence in palliative care and debate regarding its management is ongoing.AimsTo describe how delirium and its symptoms is documented in patient recordsTo determine the use of delirium screening tools and how these are viewed by staffTo identify triggers for pharmacological intervention in delirium management in a terminally ill population.MethodsA retrospective case-note review concerning all patients admitted to a hospice inpatient setting between 1–17th August 2017 and semi-structured interviews with 7 hospice doctors
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Seiler, Annina, David Blum, Jeremy Werner Deuel, et al. "Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients: Results from a prospective cohort study." Palliative and Supportive Care 19, no. 3 (2021): 294–303. http://dx.doi.org/10.1017/s147895152000139x.

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AbstractObjectiveDelirium is a frequent complication in advanced cancer patients, among whom it is frequently underdiagnosed and inadequately treated. To date, evidence on risk factors and the prognostic impact of delirium on outcomes remains sparse in this patient population.MethodIn this prospective observational cohort study at a single tertiary-care center, 1,350 cancer patients were enrolled. Simple and multiple logistic regression models were utilized to identify associations between predisposing and precipitating factors and delirium. Cox proportional-hazards models were used to estimat
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Linkaitė, Gabrielė, Mantas Riauka, Ignė Bunevičiūtė, and Saulius Vosylius. "Evaluation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for the patients in the intensive care unit." Acta medica Lituanica 25, no. 1 (2018): 14–22. http://dx.doi.org/10.6001/actamedica.v25i1.3699.

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Introduction. Delirium not only compromises patient care, but is also associated with poorer outcomes: increased duration of mechanical ventilation, higher mortality, and greater long-term cognitive dysfunction. The PRE-DELIRIC model is a tool used to calculate the risk of the development of delirium. The classification of the patients into groups by risk allows efficient initiation of preventive measures. The goal of this study was to validate the PRE-DELIRIC model using the CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit) method for the diagnosis of delirium. Materials a
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Palani, Swati, Thakkar Ravi, Makwana Milind, and Amin Naren. "A Study of Risk Factor for Delirium in Patients at Tertiary Care Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 9 (2023): 1244–49. https://doi.org/10.5281/zenodo.11385912.

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<strong>Background:</strong>&nbsp;Delirium is a clinical syndrome that usually develops in elderly patient. It is characterized by disturbance in attention (reduced ability to direct, focus, and sustain attention) awareness (reduced orientation to the environment), and cognition (memory deficit, disorientation, language, visuospatial ability or perception). The disturbance develops over short period of time (usually hours to few days), represents a change from baseline attention and awareness and tends to fluctuate in severity during the course of a day.&nbsp;<strong>Aim and Objective:</strong
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Haddad, Peter M., Majid Alabdulla, Javed Latoo, and Yousaf Iqbal. "Delirious mania in a patient with COVID-19 pneumonia." BMJ Case Reports 14, no. 11 (2021): e243816. http://dx.doi.org/10.1136/bcr-2021-243816.

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Delirious mania (the coexistence of delirium and mania) is described in the literature but not recognised in standard nosologies. We report a woman in her late 30s, with no psychiatric history, who presented with concurrent symptoms of mania and delirium. She was diagnosed with COVID-19 pneumonia (positive reverse transcription-PCR test). There was no history of substance misuse or concurrent medical illness. CT head scan was normal as were blood investigations, other than elevated inflammatory markers. She received standard treatment for COVID-19 pneumonia and lorazepam and quetiapine to trea
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Bode, Leonie, Florian Isler, Simon Fuchs, et al. "The utility of nursing instruments for daily screening for delirium: Delirium causes substantial functional impairment." Palliative and Supportive Care 18, no. 3 (2019): 293–300. http://dx.doi.org/10.1017/s1478951519001019.

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AbstractObjectiveNursing assessments have been recommended for the daily screening for delirium; however, the utility of individual items have not yet been tested. In a first step in establishing the potential of the electronic Patient Assessment-Acute Care (ePA-AC) as such, the impact of delirium on the functional domains was assessed.MethodIn this prospective observational cohort study, 277 patients were assessed and 118 patients were delirious. The impact of delirium on functional domains of the ePA-AC related to self-initiated activity, nutrition, and elimination was determined with simple
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Featherstone, Imogen, Annmarie Hosie, Najma Siddiqi, et al. "The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis." Palliative Medicine 35, no. 6 (2021): 988–1004. http://dx.doi.org/10.1177/02692163211006313.

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Background: Delirium is common in palliative care settings and is distressing for patients, their families and clinicians. To develop effective interventions, we need first to understand current delirium care in this setting. Aim: To understand patient, family, clinicians’ and volunteers’ experience of delirium and its care in palliative care contexts. Design: Qualitative systematic review and thematic synthesis (PROSPERO 2018 CRD42018102417). Data sources: The following databases were searched: CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Embas
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Bergus, Katherine, Tran Bourgeois, Kelli Patterson, Dana Schwartz, Rajan Thakkar, and Renata Fabia. "68 Using the Cornell Assessment of Pediatric Delirium Score to Identify Delirium in Pediatric Burn Patients." Journal of Burn Care & Research 44, Supplement_2 (2023): S34. http://dx.doi.org/10.1093/jbcr/irad045.042.

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Abstract Introduction Delirium rates in pediatric critical care range from 18-40% and its development is associated with baseline cognitive dysfunction, primary diagnosis, and mechanical ventilation. The Cornell Assessment of Pediatric Delirium (CAPD) is a tool used to detect delirium in children of all ages, but has not been validated in burn patients. Our study aimed to use CAPD score to determine the frequency of delirium in pediatric burn patients and assess the association of delirium with burn demographics. Methods We conducted a retrospective review of patients aged 2.5 weeks to 18 year
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Elsayem, Ahmed F., Alan D. Valentine, Carla L. Warneke, et al. "Delirium assessment in patients with advanced cancer presenting to the emergency department of a comprehensive cancer center." Journal of Clinical Oncology 33, no. 29_suppl (2015): 217. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.217.

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217 Background: The exact frequency of delirium among patients with advanced cancer presenting to emergency departments (EDs) is unknown. The purpose of this study is to determine the prevalence of delirium among patients with advanced cancer who present to the ED at MD Anderson Cancer Center. Methods: The exact frequency of delirium among patients with advanced cancer presenting to emergency departments (EDs) is unknown. The purpose of this study is to determine the prevalence of delirium among patients with advanced cancer who present to the ED at MD Anderson Cancer Center. Results: A total
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Buijs-Spanjers, Kiki R., Harianne HM Hegge, Fokie Cnossen, Debbie ADC Jaarsma, and Sophia E. de Rooij. "Reasons to Engage in and Learning Experiences From Different Play Strategies in a Web-Based Serious Game on Delirium for Medical Students: Mixed Methods Design." JMIR Serious Games 8, no. 3 (2020): e18479. http://dx.doi.org/10.2196/18479.

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Background Although many studies have recently been published on the value of serious games for medical education, little attention has been given to the role of dark play (choosing unacceptable actions in games). Objective This study aimed to investigate potential differences in the characteristics of medical students who have the opportunity to choose normal or dark play in a serious game. This study also aimed to compare their reasons for choosing a play strategy and their perceptions of what they learned from their game play. Methods We asked undergraduate medical students to play a seriou
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O’Neill, Liam, and Neale R. Chumbler. "Examining the risk of delirium in patients hospitalized with COVID-19: Insights from the homeless population." PLOS ONE 20, no. 1 (2025): e0313242. https://doi.org/10.1371/journal.pone.0313242.

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For patients hospitalized with COVID-19, delirium is a serious and under-recognized complication, and people experiencing homelessness (PEH) may be at greater risk. This retrospective cohort study compared delirium-associated risk factors and clinical outcomes between PEH and non-PEH. This study used patient records from 154 hospitals discharged from 2020–2021 from the Texas Inpatient Public Use Data file. Study subjects (n = 878) were patients, aged 18–69 years, who were hospitalized with COVID-19 and were identified as homeless. The baseline group included (n = 176,518) patients with COVID-1
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Aitken, Sarah Joy, Fiona M. Blyth, and Vasi Naganathan. "Incidence, prognostic factors and impact of postoperative delirium after major vascular surgery: A meta-analysis and systematic review." Vascular Medicine 22, no. 5 (2017): 387–97. http://dx.doi.org/10.1177/1358863x17721639.

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Although postoperative delirium is a common complication and increases patient care needs, little is known about the predictors and outcomes of delirium in patients having vascular surgery. This review aimed to determine the incidence, prognostic factors and impact of postoperative delirium in vascular surgical patients. MEDLINE and EMBASE were systematically searched for articles published between January 2000 and January 2016 on delirium after vascular surgery. The primary outcome was the incidence of delirium. Secondary outcomes were contributing prognostic factors and impact of delirium. S
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Kaye, Callum. "Do we know if our Patients are Delirious?" Journal of the Intensive Care Society 9, no. 3 (2008): 269. http://dx.doi.org/10.1177/175114370800900322.

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Delirium in the intensive care unit (ICU) setting is a significant cause of morbidity, mortality and increases ICU, as well as hospital length of stay1,2. Furthermore, with so many of the risk factors being present in the critically ill patient in the ICU environment, it's not surprising that other studies have found that up to 80% of patients will be delirious at some point during admission3,4. We performed a small study in a Toronto Medical-Surgical ICU using the Confusion Assessment Method for the ICU (CAM-ICU)5 to determine the prevalence of delirium in this unit. We concurrently reviewed
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Ali, Mohammed, Naziya Hassan, and Duprey Robert P. "Polypharmacy Induced Delirium: A Case Report Highlighting the Importance of a Thorough Psychiatric History and Physical." Neuropsychiatry 9, no. 5 (2019): 5. https://doi.org/10.5281/zenodo.13593830.

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A combative aggressive 65 year old female was brought in to the Emergency Room (ED)after found wondering in the streets. Agitated, confused, disoriented in a delirious state,she was admitted to psychiatry for diagnostic clarification. All labs except low platelets wereWithin Normal Limits (WNL). Imaging was normal. She was not a known neuro-cognitivedisorder patient. Poly-pharmacy was ruled in as the etiology of the delirium highlighting theimportance of careful prescribing especially in older persons. Moreover, this case highlightsthe importance of having expert knowledge in (a) the prescribi
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Khan, Muhammad Adnan, Muhammad Usman, Israr Hussain, et al. "Propofol Versus Dexmedetomidine Sedation Reduces Delirium." Journal of Gandhara Medical and Dental Science 10, no. 2 (2023): 92–96. http://dx.doi.org/10.37762/jgmds.10-2.372.

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OBJECTIVES Postoperative delirium (POD) is a serious complication after cardiac surgery. Use of dexmedetomidine infusion to prevent delirium is controversial. We hypothesized that dexmedetomidine sedation after cardiac surgery would reduce the incidence of POD.METHODOLOGY After the approval from institutional ethics review board and informed consent, a comparative cross sectional study was conducted in 100 patients scheduled for cardiac surgery. Patients suffering from consequential psychological issues, delirium, and grievous dementia were excluded. Delirium was evaluated by confusion assessm
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RA, Verónica. "Delirium in the Oncology Patient: Case Report." Anaesthesia & Critical Care Medicine Journal 8, no. 1 (2023): 1–7. http://dx.doi.org/10.23880/accmj-16000216.

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Delirium is an alteration of attention or consciousness accompanied by a change in basic cognition, which manifests as a decreased ability to direct, focus, maintain and shift attention. In the postoperative period it can be a factor that reduces the quality of life and perioperative outcome in cancer patients. It has been associated with increased in-hospital stay and morbidity and mortality. The following is the case of a 61-year-old patient who underwent an exploratory laparotomy and presented with hypoactive delirium with transition to hyperactive delirium in the first postoperative hours.
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Schwartz, Thomas L., Mantosh J. Dewan, and Wendy A. Armenta. "Sustained Manic Delirium." Journal of Pharmacy Technology 16, no. 4 (2000): 147–50. http://dx.doi.org/10.1177/875512250001600409.

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Objective: To report a case of bipolar I disorder with psychotic features that resembled a sustained episode of delirium. Case Summary: A 54-year-old white woman with bipolar I disorder developed severe, sustained psychosis resembling delirium. These symptoms resolved following several pharmacologic interventions. Discussion: Manic delirium is an extreme manifestation of bipolar disorder. The primary symptoms of manic delirium are confusion, agitation, altered levels of consciousness, and perceptual disturbances. Our patient developed typical symptoms of manic delirium; however, this case diff
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Leung, Jacqueline M., Laura P. Sands, Sudeshna Paul, Tim Joseph, Sakura Kinjo, and Tiffany Tsai. "Does Postoperative Delirium Limit the Use of Patient-controlled Analgesia in Older Surgical Patients?" Anesthesiology 111, no. 3 (2009): 625–31. http://dx.doi.org/10.1097/aln.0b013e3181acf7e6.

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Unlabelled BACKGROUNDPostoperative pain Is an independent predictor of postoperative delirium. Whether postoperative delirium limits patient-controlled analgesia (PCA) use has not been determined. Methods The authors conducted a nested cohort study in older patients undergoing noncardiac surgery and used PCA for postoperative analgesia. Delirium was measured by using the Confusion Assessment Method. The authors computed a structural equation model to determine the effects of pain and opioid consumption on delirium status and the effect of delirium on opioid use. Results Of 335 patients, 108 (3
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De Freitas, SA, EKC Wong, JY Lee, et al. "The Effect of Multiple Assessments on Delirium Detection: a Pilot Study*." Canadian Geriatrics Journal 23, no. 4 (2020): 277–82. http://dx.doi.org/10.5770/cgj.23.433.

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Background &#x0D; Delirium is characterized by fluctuating attention or arousal, with high prevalence in the orthopaedic ward. Our aim was to: 1) establish the prevalence of delirium on an orthopaedic ward, and 2) compare delirium prevalence using a single geriatrician assessment vs. multiple 3D-CAM (3-Minute Diagnostic Interview for Confusion Assessment Method) assessments during the day. We hypothesized that multiple assessments would increase the detection rate due to the fluctuating nature of delirium.&#x0D; Methods &#x0D; Comparative study conducted at an academic hospital in Hamilton, On
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Droogleever Fortuyn, HA, and JH Schoemaker. "Treatment of delirium with phototherapy: a case report." European Psychiatry 12, no. 7 (1997): 367–68. http://dx.doi.org/10.1016/s0924-9338(97)80007-7.

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SummaryA case is described where phototherapy rapidly restored sleep-wake disturbances and concurrent symptoms of delirium in a patient who did not respond to conventional treatment with haloperidol. In this case, the delirious state may have been caused by a change in metabolism as a result of sepsis. Exposition of the patient to 8,000 Lux during 1.5 h for 5 consecutive days was sufficient to suppress all delirious symptoms and to normalize sleep. This result may encourage the setup of systematic studies towards the extent of desynchronization between various rhythmic cycles in delirium and t
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Ceppi, Marco G., Marlene S. Rauch, Peter S. Sándor, et al. "Detecting Incident Delirium within Routinely Collected Inpatient Rehabilitation Data: Validation of a Chart-Based Method." Neurology International 13, no. 4 (2021): 701–11. http://dx.doi.org/10.3390/neurolint13040067.

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Background: Delirium is a brain condition associated with poor outcomes in rehabilitation. It is therefore important to assess delirium incidence in rehabilitation. Purpose: To develop and validate a chart-based method to identify incident delirium episodes within the electronic database of a Swiss rehabilitation clinic, and to identify a study population of validated incident delirium episodes for further research purposes. Design: Retrospective validation study. Settings: Routinely collected inpatient clinical data from ZURZACH Care. Participants: All patients undergoing rehabilitation at ZU
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Watson, H., and L. Ralston. "54 No One Told Me I Couldn’t Drive with Delirium." Age and Ageing 50, Supplement_1 (2021): i12—i42. http://dx.doi.org/10.1093/ageing/afab030.15.

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Abstract Introduction Delirium is a common cause and complication of hospital admissions. DVLA1, and Consensus guidelines2 exist for driving with dementia or mild cognitive impairment, but there are no specific guidelines pertaining to delirium. This audit set out to find the prevalence of delirium in a district general hospital prior to implementation of a standard screening tool. It was noteworthy that a significant number of patients with delirium were drivers. Methods The notes of 114 patients under the care of nine specialties, both medical and surgical were prospectively reviewed. Of tho
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Loughlin, Elaine, Miriam Conry, Catherine Gavin, et al. "107 Quality Improvement in Action! The Development of a Delirium Bay." Age and Ageing 48, Supplement_3 (2019): iii17—iii65. http://dx.doi.org/10.1093/ageing/afz103.62.

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Abstract Background As illustrated in a cross-sectional study at a Galway hospital, delirium is common with a 29% incidence in hospitalised older adults. This is associated with adverse clinical outcomes. Guidelines support specialised environments in the management of delirium to reduce morbidity and mortality. A delirium bay is a specialised unit with a standardised approach to comprehensive geriatric assessment for older adults with delirium. Methods We aimed to improve the care of the delirious older adult within our existing framework by creating a ‘Delirium Bay’ utilising the principles
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Thapa, P., PK Chakraborty, JB Khattri, K. Ramesh, and P. Sharma. "Delirium in Critically ill Patients in a Tertiary Care Centre in Western Region of Nepal." Kathmandu University Medical Journal 12, no. 2 (2015): 117–20. http://dx.doi.org/10.3126/kumj.v12i2.13657.

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Background Delirium affects a significant proportion of critically ill patients admitted in hospital. It is associated with various adverse outcomes. Despite its enormous prognostic significance it tends to be underdiagnosed. There is a dearth of studies on risk factors of delirium in our setting.Objectives The main objectives of this study was to find out the prevalence, rate of non recognition and risk factors associated with delirium in hospitalized critically ill patients.Methods A hospital based cross-sectional study was carried out. Data was collected using a predesigned semi-structured
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Gofton, Teneille Emma. "Delirium: A Review." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 38, no. 5 (2011): 673–80. http://dx.doi.org/10.1017/s0317167100012269.

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Delirium affects a diverse patient population, may present with highly variable clinical features, is a source of distress for patients and their caregivers, prolongs hospital stays and may herald a poor prognosis. Many cases of delirium are reversible and therefore a full history, physical examination and investigations should be performed. A high degree of suspicion is required for detecting delirium and thorough investigations are necessary in order to determine the underlying etiology and to maximize the potential for reversibility. The following review outlines important aspects of a clin
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Osawa, Kyoko, Satoshi Ukai, and Toshiyuki Kuriyama. "A case report of the efficacy and usefulness of asenapine in the treatment of a cancer patient with delirium and aphagia." Palliative and Supportive Care 17, no. 04 (2018): 488–91. http://dx.doi.org/10.1017/s1478951518000962.

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AbstractObjectiveControlling hyperactive and mixed delirium is extremely important for the continuation of cancer treatment in palliative care. In general, oral antipsychotics are the first-line drug therapy for delirium; however, oral administration is problematic in patients presenting dysphagia. In this case report, we describe an end-stage cancer patient with aphagia who developed delirium and responded to sublingual antipsychotic asenapine for treating delirium. We also discuss the effectiveness of asenapine in hyperactive delirium as well as its usefulness for treating delirium in pallia
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Smithburger, Pamela L., Amanda S. Korenoski, Sheila A. Alexander, and Sandra L. Kane-Gill. "Perceptions of Families of Intensive Care Unit Patients Regarding Involvement in Delirium-Prevention Activities: A Qualitative Study." Critical Care Nurse 37, no. 6 (2017): e1-e9. http://dx.doi.org/10.4037/ccn2017485.

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BACKGROUND Nonpharmacologic delirium-prevention strategies are commonly used in the intensive care unit by bedside nurses. With up to 80% of intensive care unit patients becoming delirious, and lacking treatment options, prevention is key. However, with increasing nurse workloads, innovative delirium-prevention strategies such as involving the patient’s family are needed. OBJECTIVE To gain insight into opinions of patients’ families regarding active participation in delirium-prevention activities to inform specific recommendations for involving patients’ families in such activities. METHODS Pu
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Wilke, Vera, Mihaly Sulyok, Maria-Ioanna Stefanou, et al. "Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome." PLOS ONE 17, no. 12 (2022): e0278214. http://dx.doi.org/10.1371/journal.pone.0278214.

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Introduction Delirium is recognized as a severe complication of coronavirus-disease-2019 (COVID-19). COVID-19-associated delirium has been linked to worse patient outcomes and is considered to be of multifactorial origin. Here we sought to evaluate the incidence and risk factors of delirium in hospitalized COVID-19 patients, along with its impact on clinical outcome. Methods Consecutive adult COVID-19 patients admitted to a tertiary academic referral hospital between March 1st and December 31st, 2020 were included. Potential risk factors for delirium were evaluated, including: age, gender, dis
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O'Kane, Aoibheann, Cliona Doyle, Finola Smith, et al. "Development of a Delirium Pathway for the EDITH (Emergency Department in the Home) service." International Journal of Integrated Care 25 (April 9, 2025): 327. https://doi.org/10.5334/ijic.icic24442.

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The EDITH (Emergency Department in the Home) service provides an alternative to Emergency Department attendance for the older adult by providing emergency care in the person’s home. This includes both medical and occupational therapy assessment with a focus on admission avoidance, implementing alternative care pathways and supporting patients to live at home. Currently there is an inpatient Delirium Pathway for the acute hospital setting, however there is no counterpart for the pre hospital setting. Therefore, a decision was made to develop a specific pathway for the EDITH service; a Delirium
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Brenner, Richard P. "Utility of EEG in Delirium: Past Views and Current Practice." International Psychogeriatrics 3, no. 2 (1991): 211–29. http://dx.doi.org/10.1017/s1041610291000686.

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The EEG is a useful and, at times, an essential test in the evaluation of delirium. In most patients with delirium, the EEG will show diffuse slowing and thus is helpful in differentiating organic etiologies from functional, psychiatric disorders. The degree of the EEG changes correlates with the severity of the encephalopathy so that the EEG may be used to help monitor therapy. In some delirious patients, the EEG may indicate whether the patient is suffering from focal, rather than global, impairment. Furthermore, the EEG is the only test that can identify an ongoing epileptic state (e.g., no
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Jackson, Gillian P., Catriona E. Jackson, Jason W. Boland, et al. "Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care." Palliative Medicine 38, no. 4 (2024): 447–56. http://dx.doi.org/10.1177/02692163241236325.

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Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, assessment and management. Aim: To inform a future definitive study that tests whether an implementation strategy designed to improve guideline-adherent delirium care in palliative care settings improves patient outcomes (reduced proportion of in-patient days with delirium). Design: With Patient Involvement members, we conducted a feasibility study
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Mohammed, Afsal Umehani Shreshtha Singh Dhruva Betai May Myat Mon Muhammad Khubaib Ejaz Milind Chauhan Zainab Aziz Chaudhary Tuan-Dat Nguyen Amber Fazal Elahi. "Multifactorial Insights into Delirium: A Prospective Study of ICU Risk Factors and Patient Outcomes." International Journal of Medical Science in Clinical Research and Review 7, no. 01 (2024): 78–86. https://doi.org/10.5281/zenodo.10558856.

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<strong><u>ABSTRACT</u></strong>: <strong>Background</strong>: Delirium in ICU patients is associated with increased morbidity, mortality, and healthcare costs. Despite its frequency, delirium is often underdiagnosed and, consequently, undertreated. It is a critical public health issue characterized by a sudden and fluctuating disturbance in attention and cognition. <strong>Objective</strong>: The study aims to contribute to improved quality of care and patient outcomes in the ICU by quantifying the incidence of delirium in a general ICU patient cohort. <strong>Methodology</strong>: This prosp
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Rosgen, Brianna K., Karla D. Krewulak, Henry T. Stelfox, E. Wesley Ely, Judy E. Davidson, and Kirsten M. Fiest. "The association of delirium severity with patient and health system outcomes in hospitalised patients: a systematic review." Age and Ageing 49, no. 4 (2020): 549–57. http://dx.doi.org/10.1093/ageing/afaa053.

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Abstract Background delirium is an acute state of confusion that affects &amp;gt;20% of hospitalised patients. Recent literature indicates that more severe delirium may lead to worse patient outcomes and health system outcomes, such as increased mortality, cognitive impairment and length of stay (LOS). Methods using systematic review methodology, we summarised associations between delirium severity and patient or health system outcomes in hospitalised adults. We searched MEDLINE, EMBASE, PsycINFO, CINAHL and Scopus databases with no restrictions, from inception to 25 October 2018. We included
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Marchington, Katie L., Louise Carrier, and Peter G. Lawlor. "Delirium masquerading as depression." Palliative and Supportive Care 10, no. 1 (2012): 59–62. http://dx.doi.org/10.1017/s1478951511000599.

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AbstractObjective:Despite the high prevalence of delirium in palliative care settings, this diagnosis is frequently missed, particularly in patients with hypoactive delirium. These patients are also commonly misdiagnosed with depression because of the overlap in symptoms between the two diagnoses. Failure to promptly diagnose delirium can have significant ramifications in terms of delirium reversal, subsequent patient involvement in end-of-life decision making, and the recognition and treatment of other symptoms.Method:We report a case of a 63-year-old French-speaking woman admitted to our inp
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Lange, Sandra, Wioletta Mędrzycka-Dąbrowska, Adriano Friganović, Dorota Religa, and Sabina Krupa. "Patients’ and Relatives’ Experiences of Delirium in the Intensive Care Unit—A Qualitative Study." International Journal of Environmental Research and Public Health 19, no. 18 (2022): 11601. http://dx.doi.org/10.3390/ijerph191811601.

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(1) Introduction: Delirium is a cognitive disorder that affects up to 80% of ICU patients and has many negative consequences. The occurrence of delirium in an ICU patient also negatively affects the relatives caring for these patients. The aim of this study was to explore patients’ and their families’ experiences of delirium during their ICU stay. (2) Method: The study used a qualitative design based on phenomenology as a research method. A semi-structured interview method was used to achieve the aim. The responses of patients and their families were recorded and transcribed, and the data were
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Igarashi, Masakazu, Kotoba Okuyama, Naoya Ueda, et al. "Incremental medical cost of delirium in elderly patients with cognitive impairment: analysis of a nationwide administrative database in Japan." BMJ Open 12, no. 12 (2022): e062141. http://dx.doi.org/10.1136/bmjopen-2022-062141.

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ObjectivesDelirium is a neuropsychiatric disorder that commonly occurs in elderly patients with cognitive impairment. The economic burden of delirium in Japan has not been well characterised. In this study, we assessed incremental medical costs of delirium in hospitalised elderly Japanese patients with cognitive impairment.DesignRetrospective, cross-sectional, observational study.SettingAdministrative data collected from acute care hospitals in Japan between April 2012 and September 2020.ParticipantsHospitalised patients ≥65 years old with cognitive impairment were categorised into groups—with
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Putra, Khoirun Mukhsinin, Nur Riviati, and Djunaidi AR. "Clinical Correlations Delirium and other Comorbid in Elderly with COVID-19 Infection." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 10 (2021): 949–52. http://dx.doi.org/10.32539/bsm.v5i10.361.

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Background. Delirium is a common condition in geriatric patients. One of the trigger factors for this condition is an infection, such as COVID-19 infection. Elderly with COVID-19 show atypical symptoms such as delirium. Elderly patients with COVID-19 who present with delirium, either as a primary symptom or showing symptoms or signs, have a poor prognosis. This study were aimed to presents covid-19 elderly patient with comorbid delirium.&#x0D; Case presentation. A 77-year-old woman with disorientation for one day came to Emergency Department with her family. She had no history of headaches, bl
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Putra, Khoirun Mukhsinin, Nur Riviati, and Djunaidi AR. "Clinical Correlations Delirium and other Comorbid in Elderly with COVID-19 Infection." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 4 (2021): 886–89. http://dx.doi.org/10.32539/bsm.v5i4.361.

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Background. Delirium is a common condition in geriatric patients. One of the trigger factors for this condition is an infection, such as COVID-19 infection. Elderly with COVID-19 show atypical symptoms such as delirium. Elderly patients with COVID-19 who present with delirium, either as a primary symptom or showing symptoms or signs, have a poor prognosis. This study were aimed to presents covid-19 elderly patient with comorbid delirium.&#x0D; Case presentation. A 77-year-old woman with disorientation for one day came to Emergency Department with her family. She had no history of headaches, bl
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Rabins, Peter V. "Psychosocial and Management Aspects of Delirium." International Psychogeriatrics 3, no. 2 (1991): 319–24. http://dx.doi.org/10.1017/s1041610291000765.

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Data to demonstrate that psychosocial factors, sensory deprivation, or sleep deprivation alone can cause delirium are few. Nonetheless, these factors or conditions may contribute to the development or symptom presentation of a delirium when other metabolic or toxic etiologies are present. There is likewise little research on the appropriate treatment of the delirious patient. Clinical experience suggests that attention to the patient's psychological state through frequent orientation, emotional support, and frequent explanation can help. Low-dose neuroleptic drugs are occasionally useful and n
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Nazia Arain, Fakhir Raza Haidri, Bushra Zafar, Ravi Kumar, Abdul Rahman Azam, and Sumera Imran. "Incidence and risk factors of delirium in the intensive care unit of SIUT Karachi." Professional Medical Journal 31, no. 05 (2024): 757–63. http://dx.doi.org/10.29309/tpmj/2024.31.05.8118.

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Objective: To estimate the incidence and risk factors of delirium in intensive care unit (ICU) of Sindh Institute of Urology and Transplantation (SIUT), Karachi. Study Design: Cross-sectional study. Setting: The ICU of SIUT, Karachi, Pakistan. Period: February 2023 to August, 2023. Methods: Patients over 18 years of age who were admitted to the ICU for more than 24 hours were analyzed. Patient with Richmond agitation sedation score (RASS &gt;-2) were assessed for delirium using the confusion assessment method (CAM)-ICU method. Delirium subtypes were also evaluated. Domographic and clinical ris
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