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Journal articles on the topic 'Patient Schedules'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Berg, Bjorn P., S. Ayca Erdogan, Jennifer Mason Lobo, and Kathryn Pendleton. "A Method for Balancing Provider Schedules in Outpatient Specialty Clinics." MDM Policy & Practice 5, no. 2 (2020): 238146832096306. http://dx.doi.org/10.1177/2381468320963063.

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Background. Variability in outpatient specialty clinic schedules contributes to numerous adverse effects including chaotic clinic settings, provider burnout, increased patient waiting times, and inefficient use of resources. This research measures the benefit of balancing provider schedules in an outpatient specialty clinic. Design. We developed a constrained optimization model to minimize the variability in provider schedules in an outpatient specialty clinic. Schedule variability was defined as the variance in the number of providers scheduled for clinic during each hour the clinic is open.

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2

Yartsev, Slav. "Patient-specific imaging schedules." Journal of Cancer Research and Therapeutics 11, no. 4 (2015): 1042. http://dx.doi.org/10.4103/0973-1482.146139.

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Savage, David W., Douglas G. Woolford, Bruce Weaver, and David Wood. "Developing emergency department physician shift schedules optimized to meet patient demand." CJEM 17, no. 1 (2015): 3–12. http://dx.doi.org/10.2310/8000.2013.131224.

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AbstractObjectives: 1) To assess temporal patterns in historical patient arrival rates in an emergency department (ED) to determine the appropriate number of shift schedules in an acute care area and a fast-track clinic and 2) to determine whether physician scheduling can be improved by aligning physician productivity with patient arrivals using an optimization planning model.Methods: Historical data were statistically analyzed to determine whether the number of patients arriving at the ED varied by weekday, weekend, or holiday weekend. Poisson-based generalized additive models were used to de

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Pinninti, Narsimha R., Harry Madison, Erica Musser, and David Rissmiller. "MINI International Neuropsychiatric Schedule: clinical utility and patient acceptance." European Psychiatry 18, no. 7 (2003): 361–64. http://dx.doi.org/10.1016/j.eurpsy.2003.03.004.

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AbstractObjective. –Clinical diagnosis has been shown to be unreliable compared to structured diagnostic schedules. However, clinicians rarely use structured diagnostic schedules due to concerns about the feasibility in clinical practice and about patient acceptance. Mini International Neuropsychiatric Schedule is a short diagnostic instrument validated against SCID and CIDI but its feasibility and patient acceptance has not been studied.Subjects and methods. –One hundred and eleven patients admitted to a partial program were administered Mini International Neuropsychiatric Schedule and the in

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RODRIGUES, Isabela Cristina, Rita de Cássia Martins Alves da SILVA, Helen Catharine Camarero de FELÍCIO, and Renato Ferreira da SILVA. "NEW IMMUNIZATION SCHEDULE EFFECTIVENESS AGAINST HEPATITIS B IN LIVER TRANSPLANTATION PATIENTS." Arquivos de Gastroenterologia 56, no. 4 (2019): 440–46. http://dx.doi.org/10.1590/s0004-2803.201900000-77.

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ABSTRACT BACKGROUND: Although liver transplantation is considered to be a high-risk procedure, it is well-established as a treatment option for the cure and quality of life enhancement for individuals who suffer from diseases. Preventing an infection by hepatitis B virus through immunization schedules has been the most effective way to reduce complications, since it decreases the number of people who suffer from chronic hepatitis caused by the hepatitis B virus and eradicates its transmission. OBJECTIVE: 1. Analyzing evidence in the literature on various schedules employed for immunization aga

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Tolcher, Anthony W., Wells A. Messersmith, Stanislaw M. Mikulski, et al. "Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors." Journal of Clinical Oncology 30, no. 19 (2012): 2348–53. http://dx.doi.org/10.1200/jco.2011.36.8282.

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Purpose To determine the maximum-tolerated dose (MTD) and assess safety, pharmacokinetics, pharmacodynamics, and evidence of antitumor activity of RO4929097, a gamma secretase inhibitor of Notch signaling in patients with advanced solid malignancies. Patients and Methods Patients received escalating doses of RO4929097 orally on two schedules: (A) 3 consecutive days per week for 2 weeks every 3 weeks; (B) 7 consecutive days every 3 weeks. To assess reversible CYP3A4 autoinduction, the expanded part of the study tested three dosing schedules: (B) as above; modified A, 3 consecutive d/wk for 3 we

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Heiney, Autumn, Spyros Potiris, Brian T. Denton, Amy Cohn, and Christopher Ryan Friese. "Computer simulation and stochastic programming to reduce patient wait times in an outpatient infusion center." Journal of Clinical Oncology 31, no. 31_suppl (2013): 181. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.181.

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181 Background: As cancer treatment demand outpaces the capacity of outpatient facilities, providers are challenged to provide timely, cost-effective, safe, and patient-centered care. Reduction in patient wait times can help address these challenges through more efficient care delivery. Operations research techniques such as simulation and stochastic programming can inform more efficient patient scheduling. Methods: After 60 hours of observation by two students in one NCI-designated comprehensive cancer center's outpatient infusion center, 9 months of data from the electronic medical record an

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DeAngelo, Daniel J., Harry P. Erba, Michael B. Maris, et al. "MLN4924, a Novel Investigational Inhibitor Of NEDD8-Activating Enzyme (NAE), In Adult Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS): Results From Multiple Dosing Schedules In a Phase 1 Study." Blood 122, no. 21 (2013): 1443. http://dx.doi.org/10.1182/blood.v122.21.1443.1443.

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Abstract Background NEDD8-activating enzyme (NAE) regulates the NEDD8 conjugation pathway, and is required for activity of the cullin-RING E3 ligases (CRLs). CRLs control proteasomal degradation of several substrates involved in cell-cycle regulation, signal transduction, DNA replication and stress response including proteins important for survival of AML cells. MLN4924, a first-in-class NAE inhibitor, has shown antitumor activity in preclinical AML models. This study evaluated safety and tolerability of MLN4924 given on multiple dosing schedules. A maximum tolerated dose (MTD) of 59 mg/m2 giv

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Westgard, James O., Hassan Bayat, and Sten A. Westgard. "Planning Risk-Based SQC Schedules for Bracketed Operation of Continuous Production Analyzers." Clinical Chemistry 64, no. 2 (2018): 289–96. http://dx.doi.org/10.1373/clinchem.2017.278291.

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Abstract BACKGROUND To minimize patient risk, “bracketed” statistical quality control (SQC) is recommended in the new CLSI guidelines for SQC (C24-Ed4). Bracketed SQC requires that a QC event both precedes and follows (brackets) a group of patient samples. In optimizing a QC schedule, the frequency of QC or run size becomes an important planning consideration to maintain quality and also facilitate responsive reporting of results from continuous operation of high production analytic systems. METHODS Different plans for optimizing a bracketed SQC schedule were investigated on the basis of Parvi

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Kortbeek, Nikky, Maartje E. Zonderland, Aleida Braaksma, et al. "Designing cyclic appointment schedules for outpatient clinics with scheduled and unscheduled patient arrivals." Performance Evaluation 80 (October 2014): 5–26. http://dx.doi.org/10.1016/j.peva.2014.06.003.

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Patnaik, Amita, Anna Spreafico, Alison M. Paterson, et al. "Results of a first-in-human phase I study of SRF231, a fully human, high-affinity anti-CD47 antibody." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3064. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3064.

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3064 Background: CD47 is a transmembrane protein that acts as a “Don’t Eat Me” signal to evade immune recognition. It is overexpressed in multiple cancer subtypes and is associated with poor prognosis. SRF231 is an investigational, fully human, high-affinity CD47-targeting antibody that delivers an activating signal to myeloid cells and displays favorable preclinical characteristics regarding its receptor occupancy/tumor exposure/efficacy relationship. Methods: In a Phase 1 study, SRF231-101 (NCT03512340), patients with advanced solid and hematologic malignancies who had failed standard therap

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Baracena, Daphne, Jerry Jeff Jaboin, and Michelle Bednar. "Improving patient access in radiation oncology from referral to consult." Journal of Clinical Oncology 37, no. 27_suppl (2019): 122. http://dx.doi.org/10.1200/jco.2019.37.27_suppl.122.

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122 Background: To increase patient access, Oregon Health & Science University set an institution-wide metric for ambulatory clinics to contact the patient within a specified time frame. For our study, we utilized targets of patient contact within three days from the date of referral and of scheduling and resolving referrals within six days. Since the reports for these metrics did not provide detailed reasons for the consult delays, we were unable to assess if these delays were due to pending patient action, provider recommendations, providers’ overbooked schedules, and/or an inefficient i

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Kapetanakis, Venediktos, Thibaud Prawitz, Michael Schlichting, et al. "Comparing progression-free survival (PFS) in second-line (2L) urothelial carcinoma (UC) treatments from single-arm trials: Importance of using appropriate methods." Journal of Clinical Oncology 38, no. 6_suppl (2020): 573. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.573.

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573 Background: Population-adjusted comparisons of PFS from single-arm trials of cancer treatments can be derived using matching-adjusted indirect comparison (MAIC); however, results are still susceptible to bias, particularly if the trials had different tumor assessment schedules (favoring longer intervals). This is shown with an MAIC of avelumab vs atezolizumab, nivolumab, durvalumab, pembrolizumab or chemotherapy in 2L UC. Methods: The MAIC used patient-level data for avelumab from the JAVELIN Solid Tumor trial (NCT01772004) and compared PFS with published curves for other treatments to obt

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Paniagua, Ramón, Malgorzata Debowska, María-De-Jesús Ventura, et al. "Ultrafiltration and Dialysis Adequacy with Various Daily Schedules of Dialysis Fluids." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 32, no. 5 (2012): 545–51. http://dx.doi.org/10.3747/pdi.2011.00048.

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Dialysis regimens for continuous ambulatory peritoneal dialysis (CAPD) patients vary with the need for fluid removal, but also because of concerns about the local and systemic consequences of high glucose exposure. The implications of various regimens for dialysis adequacy—that is, fluid and small-solute removal—are not always clear. We therefore analyzed ultrafiltration (UF) and adequacy indices for 4 different combinations of dialysis fluid.Collections of 24-hour dialysate and urine were carried out in 99 patients on CAPD. On 4 separate occasions, each patient performed 4 exchanges in 24 hou

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Tomer, Anirudh, Dimitris Rizopoulos, Daan Nieboer, Frank-Jan Drost, Monique J. Roobol, and Ewout W. Steyerberg. "Personalized Decision Making for Biopsies in Prostate Cancer Active Surveillance Programs." Medical Decision Making 39, no. 5 (2019): 499–508. http://dx.doi.org/10.1177/0272989x19861963.

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Background. Low-risk prostate cancer patients enrolled in active surveillance programs commonly undergo biopsies for examination of cancer progression. Biopsies are conducted as per a fixed and frequent schedule (e.g., annual biopsies). Since biopsies are burdensome, patients do not always comply with the schedule, which increases the risk of delayed detection of cancer progression. Objective. Our aim is to better balance the number of biopsies (burden) and the delay in detection of cancer progression (less is beneficial) by personalizing the decision of conducting biopsies. Data Sources. We u

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Salcido, Richard “Sal. "Patient Turning Schedules: Why and How Often?" Advances in Skin & Wound Care 17, no. 4 (2004): 156. http://dx.doi.org/10.1097/00129334-200405000-00001.

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Singh, Suvir, and Komalpreet Kaur. "Physician schedules and patient safety: Critical appraisal." National Medical Journal of India 33, no. 6 (2020): 359. http://dx.doi.org/10.4103/0970-258x.321146.

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Vieira, Bruno, Derya Demirtas, Jeroen B. van de Kamer, Erwin W. Hans, Willem Jongste, and Wim van Harten. "Radiotherapy treatment scheduling: Implementing operations research into clinical practice." PLOS ONE 16, no. 2 (2021): e0247428. http://dx.doi.org/10.1371/journal.pone.0247428.

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Background Every week, radiotherapy centers face the complex task of scheduling hundreds of treatment sessions amongst the available linear accelerators. With the increase in cancer patient numbers, manually creating a feasible and efficient schedule has shown to be a difficult, time-consuming task. Although operations research models have been increasingly reported upon to optimize patient care logistics, there is almost no scientific evidence of implementation in practice. Methods A mathematical operations research model was adapted to generate radiotherapy treatment schedules in two Dutch c

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Wang, Yadan, Yu Hu, Lisha Ai, et al. "Once Weekly Bortezomib Plus Dexamethasone in Newly Diagnosed Multiple Myeloma: A Preliminary Study in Chinese Patients." Blood 118, no. 21 (2011): 5128. http://dx.doi.org/10.1182/blood.v118.21.5128.5128.

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Abstract Abstract 5128 Introduction: Bortezomib has become a cornerstone in the management of multiple myeloma (MM) and the currently accepted practice is a twice weekly administration at 1.3mg/m2. Recently, several studies have demonstrated a successful treatment with the modified Bortezomib schedule in refractory or elderly newly diagnosed MM. These previous studies suggest that, given at weekly intervals, Bortezomib remains equally efficacious and may even improve tolerability. We here present our institution's experience where we retrospectively compare the efficacy and toxicity parameters

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Barysauskas, Constance, Gina Hudgins, Katie Kupferberg Gill, et al. "Measuring chemotherapy appointment duration and variation utilizing real-time location systems (RTLS)." Journal of Clinical Oncology 32, no. 30_suppl (2014): 154. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.154.

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154 Background: Clinical schedules drive resource utilization, cost, and patient wait time. Accurate appointment durations ensure appropriate staffing ratios to the daily caseload and maximizes scarce resources. Dana-Farber Cancer Institute (DFCI) adjusts infusion appointment durations for each chemotherapy regimen using a consensus method of experts including pharmacists, nurses, and administrators. Utilizing RTLS, we examined the accuracy of appointment duration compared to suggested duration. Methods: Appointment duration was calculated using RTLS in three disease centers at DFCI between Au

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Srinivas, Sandy, Carol Mansfield, Rickard Sandin, et al. "Exploring the effect of medication features in renal cell carcinoma: A patient preference study." Journal of Clinical Oncology 33, no. 7_suppl (2015): 463. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.463.

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463 Background: Limited information exists about patient preference (PP) for renal cell carcinoma (RCC) medication profiles, especially related to uncertainty in outcomes, potential correlation between toxicity and efficacy, and dosing schedules. Methods: RCC patients in the United States and Canada completed an online survey with questions that examined PP for medication profiles by varying efficacy (progression free survival [PFS]), tolerability (fatigue, hand-foot syndrome, hypertension, diarrhea) and dosing schedules (with or without 2 week break). A discrete-choice experiment (DCE) survey

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Huang, Yu-Li, Narges Shahraki, Erin M. Wallin, Eric W. Klavetter, and Kyle W. Klarich. "Provider time allotment tracking tool to effectively manage assignment commitments." Journal of Hospital Administration 10, no. 3 (2021): 10. http://dx.doi.org/10.5430/jha.v10n3p10.

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Due to the rising demand with limited health service capacity, managing available resources effectively becomes an important task to reduce patient care delays and avoid unnecessary and costly capacity expansions. At the same time, staff satisfaction and/or burnout is a complementary consideration when designing optimal schedules. Deviation from the scheduled plan can cause delays in patient access and may lead to unsatisfaction among providers. Balancing demand management, staff satisfaction and generating optimized schedules quickly reveals the need for a tool that tracks provider time allot

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Sweeney, Christopher J., E. Gabriela Chiorean, Claire F. Verschraegen, et al. "A Phase I Study of Sunitinib Plus Capecitabine in Patients With Advanced Solid Tumors." Journal of Clinical Oncology 28, no. 29 (2010): 4513–20. http://dx.doi.org/10.1200/jco.2009.26.9696.

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Purpose This open-label, phase I, dose-escalation study assessed the maximum-tolerated dose (MTD), safety, pharmacokinetics, and antitumor activity of sunitinib in combination with capecitabine in patients with advanced solid tumors. Patients and Methods Sunitinib (25, 37.5, or 50 mg) was administered orally once daily on three dosing schedules: 4 weeks on treatment, 2 weeks off treatment (Schedule 4/2); 2 weeks on treatment, 1 week off treatment (Schedule 2/1); and continuous daily dosing (CDD schedule). Capecitabine (825, 1,000, or 1,250 mg/m2) was administered orally twice daily on days 1 t

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Pan, Ling, Peijia Ren, and Zeshui Xu. "Therapeutic Schedule Evaluation for Brain-Metastasized Non-Small Cell Lung Cancer with A Probabilistic Linguistic ELECTRE II Method." International Journal of Environmental Research and Public Health 15, no. 9 (2018): 1799. http://dx.doi.org/10.3390/ijerph15091799.

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With the rapid development of modern medicine, therapeutic schedules of brain-metastasized non-small cell lung cancer (NSCLC) are expanding. To assist a patient who suffers from brain-metastasized NSCLC to select the most suitable therapeutic schedule, firstly, we establish an indicator system for evaluating the therapeutic schedules; then, we propose a probabilistic linguistic ELECTRE II method to handle the corresponding evaluation problem for the following reasons: (1) probabilistic linguistic information is effective to depict the uncertainty of the therapeutic process and the fuzziness of

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Vainstein, Vladimir, Yuval Ginosar, Meir Shoham, et al. "Clinical Validation of a Physiologically-Based Computer Model of Human Granulopoiesis and Its Use for Improving Cancer Therapy by Doxorubicin and Granulocyte Colony-Stimulating Factor (GCSF)." Blood 108, no. 11 (2006): 3848. http://dx.doi.org/10.1182/blood.v108.11.3848.3848.

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Abstract Neutropenia is a dose-limiting toxicity in dose-intensified chemotherapy regimens. Yet to be determined are the lower limit of inter-dosing interval of chemotherapy and the optimal schedules of GCSF support. In the absence of better tools, the most promising schedules to be tested in clinical trials are selected by trial and error. In order to provide a scientific tool for treatment selection, a physiologically-based, computer-implemented, mathematical model of human granulopoiesis was recently developed (Vainstein et al, J Theor Biol, 2005). The aim of the current study is to validat

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Lyons, Declan, Mark Amos, and V. M. Mathew. "Structured psychiatric assessment schedules – treating the case notes and the patient." Psychiatric Bulletin 25, no. 11 (2001): 418–20. http://dx.doi.org/10.1192/pb.25.11.418.

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Aims and MethodWe surveyed the usefulness of a structured method of recording history and mental state examinations with a treatment plan in terms of conveying information about diagnosis and management, compared with informal methods of recording data. A survey of admission records by nursing and medical raters was followed by introduction of a standardised assessment format for use by trainees and a re-audit. Initial psychotropic medication was also scrutinised.ResultsThe assessment schedule improved clarity of diagnosis for the medical and nursing raters alike, but improvement in management

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Oettle, H., A. Hilbig, T. Seufferlein, et al. "Interim results of the phase I/II study of trabedersen (AP 12009) in patients with pancreatic carcinoma, malignant melanoma, or colorectal carcinoma." Journal of Clinical Oncology 27, no. 15_suppl (2009): 4619. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4619.

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4619 Background: TGF-beta 2 is one of the most potent immunosuppressors and mediates escape from immunosurveillance. It also plays a crucial role in tumor progression by regulating metastasis, angiogenesis, and proliferation. Trabedersen, a TGF-beta 2-specific inhibitor has already shown a clear survival benefit in a randomized active-controlled phase II study in high-grade glioma patients, compared to standard chemotherapy. Methods: 33 patients with advanced pancreatic carcinoma (stage IVA/IVB) (N=23), malignant melanoma (stage III/IV) (N=5) or colorectal carcinoma (stage III/IV) (N=5) were t

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Garcia-Manero, Guillermo, Steven D. Gore, Christopher R. Cogle, et al. "Evaluation of Oral Azacitidine Using Extended Treatment Schedules: A Phase I Study." Blood 116, no. 21 (2010): 603. http://dx.doi.org/10.1182/blood.v116.21.603.603.

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Abstract Abstract 603 Parenteral azacitidine (AZA) is approved for administration on days 1–7 of a 28-day treatment schedule. Based on the short plasma half-life of AZA, S-phase restricted incorporation into DNA, and rapid re-methylation of DNA, it is possible that chronic daily exposure could enhanced its clinical activity. An oral formulation would be convenient and allow evaluation of lower doses administered on extended schedules. The initial phase I study of oral AZA, administered daily on a 7-day schedule demonstrated that it was bioavailable, safe, and clinically active in patients with

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Althaus, Betsy L. "Myeloid Growth Factor Therapy for Prophylaxis of Febrile Neutropenia in Non-Myeloid Malignancies: Appropriate Doses and Schedules." Journal of the National Comprehensive Cancer Network 5, no. 2 (2007): 229–34. http://dx.doi.org/10.6004/jnccn.2007.0022.

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Myeloid growth factors (MGFs) are used for the prophylaxis of febrile neutropenia and maintenance of scheduled dose delivery in the treatment of patients undergoing cancer chemotherapy. To spare cost and for patient convenience, in adults MGFs are used at schedules, doses, and durations that differ from the approved prescribing information of the U.S. Food and Drug Administration. These variations include rounding doses to convenient sizes, fewer days of treatment, a shorter interval between cycles, and same-day administration with chemotherapy. Some of these variations are supported by clinic

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Levi, Shoshana, Emily Alberto, Dakota Urban, Nicholas Petrelli, and Gregory Tiesi. "Health-Care Workers’ Perception of Reimbursement for Complex Surgical Oncology Procedures." American Surgeon 86, no. 2 (2020): 140–45. http://dx.doi.org/10.1177/000313482008600234.

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Perception of physician reimbursement for surgical procedures is not well studied. The few existing studies illustrate that patients believe compensation to be higher than in reality. These studies focus on patient perceptions and have not assessed health-care workers’ views. Our study examined health-care workers’ perception of reimbursement for complex surgical oncology procedures. An anonymous online survey was distributed to employees at our cancer center with descriptions and illustrations of three oncology procedures—hepatectomy, gastrectomy, and pancreaticoduodenectomy. Participants est

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Cipriano, Lauren E., Shan Liu, Kaspar S. Shahzada, Mark Holodniy, and Jeremy D. Goldhaber-Fiebert. "Economically Efficient Hepatitis C Virus Treatment Prioritization Improves Health Outcomes." Medical Decision Making 38, no. 7 (2018): 849–65. http://dx.doi.org/10.1177/0272989x18792284.

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Background. The total cost of treating the 3 million Americans chronically infected with hepatitis C virus (HCV) represents a substantial affordability challenge requiring treatment prioritization. This study compares the health and economic outcomes of alternative treatment prioritization schedules. Methods. We developed a multiyear HCV treatment budget allocation model to evaluate the tradeoffs of 7 prioritization strategies. We used optimization to identify the priority schedule that maximizes population net monetary benefit (NMB). We compared prioritization schedules in terms of the number

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Sauerbaum, James J., Gina DeMaio, Bradley Geiger, et al. "Minimizing wait time between chemotherapy and radiotherapy treatments." Journal of Clinical Oncology 30, no. 34_suppl (2012): 82. http://dx.doi.org/10.1200/jco.2012.30.34_suppl.82.

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82 Background: Members of the scheduling teams at the Abramson Cancer Center observed prolonged delays between chemotherapy and radiation therapy treatments scheduled by staff from 2 independent departments leading to inconvenience for patients receiving concurrent chemo- and radiation therapy (CRpts). Methods: An analysis of baseline data over 6 weeks revealed that for 157 unique consecutive patients undergoing daily chemotherapy and radiation (a total of 353 encounters), the mean time between scheduled treatments was 122 minutes. For 39% of encounters the wait time was greater than 120 minut

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Landrigan, Christopher P., Shadab A. Rahman, Jason P. Sullivan, et al. "0995 Schedule Re-design and Patient Safety: the Randomized Order Safety Trial Evaluating Resident-Physician Schedules (ROSTERS)." Sleep 42, Supplement_1 (2019): A400—A401. http://dx.doi.org/10.1093/sleep/zsz067.992.

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Munavalli, Jyoti R., Shyam Vasudeva Rao, Aravind Srinivasan, and GG van Merode. "An intelligent real-time scheduler for out-patient clinics: A multi-agent system model." Health Informatics Journal 26, no. 4 (2020): 2383–406. http://dx.doi.org/10.1177/1460458220905380.

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Scheduling of resources and patients are crucial in outpatient clinics, particularly when the patient demand is high and patient arrivals are random. Generally, outpatient clinic systems are push systems where scheduling is based on average demand prediction and is considered for long term (monthly or bimonthly). Often, planning and actual scenario vary due to uncertainty and variability in demand and this mismatch results in prolonged waiting times and under-utilization of resources. In this article, we model an outpatient clinics as a multi-agent system and propose an intelligent real-time s

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Garcia, Regina, Dunia de Miguel, Alicia Bailen, et al. "Different Clinical Results with the Use of Different Dosing Schedules of Azacitidine in Patients with Myelodysplastic Syndrome Managed in Community-Based Practice: Effectiveness and Safety Data From the Spanish Azacitidine Compassionate Use Registry." Blood 114, no. 22 (2009): 2773. http://dx.doi.org/10.1182/blood.v114.22.2773.2773.

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Abstract Abstract 2773 Poster Board II-749 Background: Azacitidine (AZA), a hypomethylating agent recently approved in Europe for the treatment of myelodysplastic syndrome (MDS), prolongs the median survival time in patients enrolled in clinical trials (Fenaux et al 2009). AZA was available for clinical trial or compassionate use in Spain before receiving its marketing authorization from the Spanish Medicines Agency in May 2009. The dosing of AZA in community-based hematology clinics could differ from that approved by the health authorities. Material and Methods: We present the preliminary ana

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Oliveira, Mariana, Valérie Bélanger, Inês Marques, and Angel Ruiz. "Assessing the impact of patient prioritization on operating room schedules." Operations Research for Health Care 24 (March 2020): 100232. http://dx.doi.org/10.1016/j.orhc.2019.100232.

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Nolting, Siegfried K., Jose Sanchez Carazo, Koenrad De Boulle, and Julien R Lambert. "Oral treatment schedules for onychomycosis: a study of patient preference." International Journal of Dermatology 37, no. 6 (1998): 454–56. http://dx.doi.org/10.1046/j.1365-4362.1998.00357.x.

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Shah, Jatin J., R. Donald Harvey, Owen A. O'Connor, et al. "Phase 1 Dose-Escalation Study of Multiple Dosing Schedules of the Investigational Drug MLN4924, a Nedd8-Activating Enzyme Inhibitor, In Patients with Relapsed and/or Refractory Multiple Myeloma or Lymphoma." Blood 116, no. 21 (2010): 2801. http://dx.doi.org/10.1182/blood.v116.21.2801.2801.

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Abstract Abstract 2801 Background: MLN4924 is an investigational inhibitor of Nedd8-activating enzyme (NAE), which plays an essential role in regulating the activity of the cullin-RING E3 ligases (CRLs). NAE controls the neddylation cascade that results in Nedd8 conjugation to the CRLs, which is required for ligase activity. NAE inhibition thus inhibits ubiquitination and proteasomal degradation of CRL substrates, which include proteins involved in cell-cycle regulation (p27), signal transduction (pIκBα), DNA replication (Cdt-1), stress response (Nrf-2), and other processes important to tumor

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Sobel, Halle G., Rachel Swigris, Karen M. Chacko, et al. "Resident and Preceptor Perceptions of Preceptor Integration Into Resident Clinic Scheduling Templates." Journal of Graduate Medical Education 9, no. 4 (2017): 497–502. http://dx.doi.org/10.4300/jgme-d-16-00609.1.

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ABSTRACT Background Some internal medicine residency programs on X+Y schedules have modified clinic preceptor schedules to mimic those of the resident cohort (resident matched). This is in contrast to a traditional model, in which preceptors supervise on the same half-day each week. Objective We assessed preceptor and resident perceptions of the 2 precepting models. Methods We surveyed 44 preceptors and 97 residents at 3 clinic sites in 2 academic medical centers. Two clinics used the resident-matched model, and 1 used a traditional model. Surveys were completed at 6 months and 1 year. We asse

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Khan, Maliha, Hagop M. Kantarjian, Guillermo Garcia-Manero, et al. "Randomized Phase II Trial of Two Schedules of Decitabine As Frontline Therapy in Elderly Patients with Acute Myeloid Leukemia Ineligible for Standard Cytotoxic Induction Regimens." Blood 128, no. 22 (2016): 1612. http://dx.doi.org/10.1182/blood.v128.22.1612.1612.

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Abstract BACKGROUND The hypomethylating agents decitabine and 5-azacytidine are commonly used for the initial treatment of acute myeloid leukemia (AML) in elderly patients deemed unfit to receive standard cytotoxic induction chemotherapy. Decitabine at the approved schedule of 20 mg/m2daily for 5 days was shown to be superior to supportive care or low dose cytarabine. (Kantarjian H, JCO; 30(21):2670, 2012). An extended 10-day schedule of decitabine was reported to have a significantly higher response rate (Blum W, PNAS; 107(16):7473, 2010) OBJECTIVES The primary objective of the current study

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Heinemann, V., E. Estey, M. J. Keating, and W. Plunkett. "Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia." Journal of Clinical Oncology 7, no. 5 (1989): 622–28. http://dx.doi.org/10.1200/jco.1989.7.5.622.

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We hypothesized that the steady-state concentration of intracellular cytarabine 5'-triphosphate (ara-CTPss) in leukemia cells is proportional to the dose rate of cytarabine (ara-C) during continuous infusion. To evaluate this possibility, patients with acute myelogenous leukemia in relapse were treated with two sequential schedules of serially increasing ara-C dose rates over a total of 36 hours. Schedule I consisted of serial infusions of 250, 500, and 750 mg/m2 each over 12 hours. Subsequently, patients entered on schedule II received 500, 1,000, and 1,500 mg/m2 serially, each over 12 hours.

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BARROWCLOUGH, C., M. MARSHALL, A. LOCKWOOD, J. QUINN, and W. SELLWOOD. "Assessing relatives' needs for psychosocial interventions in schizophrenia: a relatives' version of the Cardinal Needs Schedule (RCNS)." Psychological Medicine 28, no. 3 (1998): 531–42. http://dx.doi.org/10.1017/s003329179800662x.

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Background. The methodology for measuring the needs of patients with severe mental illness is now well established through the MRC Needs for Care Assessment Schedule and its modification in the form of the Cardinal Needs Assessment. This paper reports the rationale and construction of a relatives' version of the Cardinal Needs Schedule and looks at preliminary data reporting on reliability and validity.Methods. Potential problem areas for relatives were identified from the literature. The criteria determining Cardinal Needs for each problem included objective threshold, carer concern, and care

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Fennelly, D., C. Aghajanian, F. Shapiro, et al. "Phase I and pharmacologic study of paclitaxel administered weekly in patients with relapsed ovarian cancer." Journal of Clinical Oncology 15, no. 1 (1997): 187–92. http://dx.doi.org/10.1200/jco.1997.15.1.187.

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PURPOSE Paclitaxel has shown significant activity in advanced ovarian cancer. In vitro studies with paclitaxel have suggested that fractionated brief infusion schedules may be more effective than the standard 24-hour infusion. We commenced a phase I evaluation of escalating-dose paclitaxel (40, 50, 60, 80, 100 mg/m2) administered weekly as a 1-hour infusion in patients with recurrent ovarian cancer. All patients had received prior paclitaxel and cisplatin therapy. All patients received standard premedication. PATIENTS AND METHODS Eighteen patients are assessable on this phase I study. The mean

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Monahan, Paul E., Raina Liesner, Sharon Sullivan, et al. "Investigator-Prescribed Prophylaxis of rFIX (BeneFIX®) in Children <6 Years of Age: Efficacy and Safety Outcomes." Blood 112, no. 11 (2008): 1221. http://dx.doi.org/10.1182/blood.v112.11.1221.1221.

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Abstract Prophylaxis is increasingly prescribed in treatment of hemophilia. The therapeutic benefit is believed to be most significant for the youngest patients since hemophilic arthropathy may be prevented if prophylaxis is initiated prior to recurrent hemarthroses. While clinical prophylaxis data is readily available for hemophilia A, analogous data for hemophilia B is limited. A prospective clinical study of recombinant human FIX (rFIX; BeneFIX®) was recently completed in which the efficacy and safety of rFIX were evaluated in children &lt;6 years of age with severe hemophilia B (FIX ac

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Codina, Carles J., Pilar U. Sarda, Enriqueta L. Salvador, Josep J. Monterde, and Josep S. Ribas. "Database program for creating individualized patient drug information and medication schedules." American Journal of Health-System Pharmacy 49, no. 1 (1992): 131–32. http://dx.doi.org/10.1093/ajhp/49.1.131.

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Dowdy, David W., Claire K. Horton, Ben Lau, Rosaly Ferrer, and Alice H. Chen. "Patient Follow-up in an Urban Resident Continuity Clinic: An Initiative to Improve Scheduling Practices." Journal of Graduate Medical Education 3, no. 2 (2011): 256–60. http://dx.doi.org/10.4300/jgme-d-10-00196.1.

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Abstract Introduction Failure to schedule timely follow-up appointments may impair continuity and quality of care, especially for patients with low health literacy and unstable living situations. Resident continuity clinics face particular challenges in scheduling patient follow-up because of residents' complex schedules and limited time in clinic. Methods As part of a structured quality-improvement curriculum, residents initiated discussions with clinical supervisors and clerical staff to evaluate and improve scheduling practices in an urban continuity clinic. The problem-solving process emph

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Dearnaley, David P., Isabel Syndikus, Helen Mossop, et al. "Comparison of hypofractionated high-dose intensity-modulated radiotherapy schedules for prostate cancer: Results from the phase III randomized CHHiP trial (CRUK/06/016)." Journal of Clinical Oncology 34, no. 2_suppl (2016): 2. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.2.

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2 Background: We aimed to explore the dose response relationship for two 3 Gray (Gy) hypofractionated radiotherapy (hRT) schedules for localised prostate cancer (PCa). Methods: hRT schedules of 60Gy/20 fractions (f) and 57Gy/19f were compared with conventional RT (cRT) 74Gy/37f; iso-effective for alpha-beta ratios of 2.5Gy and 1.5Gy respectively. The trial was powered to demonstrate non-inferiority between each hRT schedule and cRT, with 3,213 patients (pt) needed to rule out 5% inferiority (80% power, 1-sided alpha 5%) assuming 70% event-free rate in cRT, corresponding to a critical hazard ra

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Shakespeare, Thomas P., Jiade J. Lu, Michael F. Back, Shen Liang, Rahul K. Mukherjee, and Christopher J. Wynne. "Patient Preference for Radiotherapy Fractionation Schedule in the Palliation of Painful Bone Metastases." Journal of Clinical Oncology 21, no. 11 (2003): 2156–62. http://dx.doi.org/10.1200/jco.2003.10.112.

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Purpose: The radiotherapeutic management of painful bone metastases is controversial, with several institutional and national guidelines advocating use of single-fraction radiotherapy. We aimed to determine patient choice of fractionation schedule after involvement in the decision-making process by use of a decision board. Patients and Methods: Advantages and disadvantages of two fractionation schedules (24 Gy in six fractions v 8 Gy in one fraction) used in the randomized Dutch Bone Metastasis Study were discussed with patients using a decision board. Patients were asked to choose a fractiona

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Williams, Kayode A., Chester G. Chambers, Maqbool Dada, Douglas Hough, Ravi Aron, and John A. Ulatowski. "Using Process Analysis to Assess the Impact of Medical Education on the Delivery of Pain Services." Anesthesiology 116, no. 4 (2012): 931–39. http://dx.doi.org/10.1097/aln.0b013e31824a88d0.

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Background The medical, social, and economic effects of the teaching mission on delivery of care at an academic medical center (AMC) are not fully understood. When a free-standing private practice ambulatory clinic with no teaching mission was merged into an AMC, a natural experiment was created. The authors compared process measures across the two settings to observe the differences in system performance introduced by the added steps and resources of the AMC's teaching mission. Methods After creating process maps based on activity times realized in both settings, the authors developed discret

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Tangvoraphonkchai, Kamonwan, and Andrew Davenport. "Increasing Haemodialytic Clearances as Residual Renal Function Declines: An Incremental Approach." Blood Purification 44, no. 3 (2017): 217–26. http://dx.doi.org/10.1159/000475458.

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Many patients with chronic kidney disease start undergoing thrice-weekly haemodialysis (HD), aiming for an HD sessional dialyzer urea clearance target, irrespective of whether they have residual renal function (RRF). While increasing sessional dialyzer urea clearance above a target of 1.2 has not been shown to improve patient survival, it has been shown that the preservation of RRF improves patient self-reported outcomes and survival. Observational studies have suggested that initiating twice-weekly HD schedules leads to greater preservation of RRF. This has led to the concept of following an

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