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Relevant bibliographies by topics / Paxt-Next

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Academic literature on the topic 'Paxt-Next'

Author: Grafiati

Published: 4 April 2023

Last updated: 31 July 2025

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Journal articles on the topic "Paxt-Next"

1

Gockert, Maria, Manfred Schmid, Lis Jakobsen, Marvin Jens, Jens S. Andersen, and Torben Heick Jensen. "Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation." Nucleic Acids Research 50, no. 3 (2022): 1583–600. http://dx.doi.org/10.1093/nar/gkac001.

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Abstract Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly(A) tail eXosome Targeting (PAXT) connection. Functional analyses of NEXT and PAXT have largely utilized long-term factor depletion strategies, facilitating the appearance of indirect phenotypes. Here, we rapidly deplete NEXT, PAXT and core exosome components, uncovering the direct consequences of their acute losses. Generally, proteome changes are sparse and largely dominated by co-depletion of other exosome and adaptor

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2

Contreras, Xavier, David Depierre, Charbel Akkawi та ін. "PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs". Nature Communications 14, № 1 (2023). http://dx.doi.org/10.1038/s41467-023-42620-9.

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AbstractPervasive transcription of the human genome generates an abundance of RNAs that must be processed and degraded. The nuclear RNA exosome is the main RNA degradation machinery in the nucleus. However, nuclear exosome must be recruited to its substrates by targeting complexes, such as NEXT or PAXT. By proteomic analysis, we identify additional subunits of PAXT, including many orthologs of MTREC found in S. pombe. In particular, we show that polyA polymerase gamma (PAPγ) associates with PAXT. Genome-wide mapping of the binding sites of ZFC3H1, RBM27 and PAPγ shows that PAXT is recruited to

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3

Wu, Mengjun, Manfred Schmid, Torben Heick Jensen, and Albin Sandelin. "Computational identification of signals predictive for nuclear RNA exosome degradation pathway targeting." NAR Genomics and Bioinformatics 4, no. 3 (2022). http://dx.doi.org/10.1093/nargab/lqac071.

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Abstract The RNA exosome degrades transcripts in the nucleoplasm of mammalian cells. Its substrate specificity is mediated by two adaptors: the ‘nuclear exosome targeting (NEXT)’ complex and the ‘poly(A) exosome targeting (PAXT)’ connection. Previous studies have revealed some DNA/RNA elements that differ between the two pathways, but how informative these features are for distinguishing pathway targeting, or whether additional genomic features that are informative for such classifications exist, is unknown. Here, we leverage the wealth of available genomic data and develop machine learning mo

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4

Kwiatek, Lauren, Anne-Marie Landry-Voyer, Melodie Latour, Carlo Yague-Sanz, and Francois Bachand. "PABPN1 prevents the nuclear export of an unspliced RNA with a constitutive transport element and controls human gene expression via intron retention." RNA, February 8, 2023, rna.079294.122. http://dx.doi.org/10.1261/rna.079294.122.

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Intron retention is a type of alternative splicing where one or more introns remain unspliced in a polyadenylated transcript. Although many viral systems are known to translate proteins from mRNAs with retained introns, restriction mechanisms generally prevent export and translation of incompletely spliced mRNAs. Here we provide evidence that the human nuclear poly(A)-binding protein, PABPN1, functions in such restriction. Using a reporter construct in which nuclear export of an incompletely spliced mRNA is enhanced by a viral constitutive transport element (CTE), we show that PABPN1 depletion

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Dissertations / Theses on the topic "Paxt-Next"

1

Heurteau, Alexandre. "Etude bioinformatique intégrative : déterminants et dynamique des interactions chromosomiques à longue distance." Electronic Thesis or Diss., Toulouse 3, 2019. http://www.theses.fr/2019TOU30343.

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Les protéines se liants aux insulateurs (IBPs) seraient impliquées dans la structuration tri-dimensionnelle des génomes en domaines topologiques (ou " TADs). Les TADs contribueraient notamment à séparer les compartiments inactifs/hétérochromatine et actifs/euchromatine. Les IBPs sont également capables de bloquer les contacts spécifiques entre les éléments activateurs ou "enhancers" d'un TAD et les promoteurs de gènes cibles présents dans un autre TAD. Ainsi, les insulateurs influenceraient l'expression des gènes selon plusieurs modes de régulations qui reste à être caractérisés à l'échelle du

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