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Journal articles on the topic 'PBDs'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Dechent, Sarah-Elisabeth, Arjan W. Kleij, and Gerrit A. Luinstra. "Fully bio-derived CO2 polymers for non-isocyanate based polyurethane synthesis." Green Chemistry 22, no. 3 (2020): 969–78. http://dx.doi.org/10.1039/c9gc03488a.

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Jakše, Jakše, Pajek, and Pajek. "Uric Acid and Plant-Based Nutrition." Nutrients 11, no. 8 (July 26, 2019): 1736. http://dx.doi.org/10.3390/nu11081736.

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Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and brassica vegetables) also contain a high purine load. Suboptimally designed PBDs might consequently be associated with increased uric acid levels and gout development. Here, we review the available data on this topic, with a great majority of studies showing reduced risk of hyperur

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Abel, R. J. R., and F. E. Bennett. "Quintessential PBDs and PBDs with prime power block sizes ≥ 8." Journal of Combinatorial Designs 13, no. 4 (2005): 239–67. http://dx.doi.org/10.1002/jcd.20036.

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Al-Bahlani, Shadia, Buthaina Al-Dhahli, Kawther Al-Adawi, Abdurahman Al-Nabhani, and Mohamed Al-Kindi. "Platinum-Based Drugs Differentially Affect the Ultrastructure of Breast Cancer Cell Types." BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/3178794.

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Breast cancer (BC) is the most common cause of cancer-related death worldwide. Although platinum-based drugs (PBDs) are effective anticancer agents, responsive patients eventually become resistant. While resistance of some cancers to PBDs has been explored, the cellular responses of BC cells are not studied yet. Therefore, we aim to assess the differential effects of PBDs on BC ultrastructure. Three representative cells were treated with different concentrations and timing of Cisplatin, Carboplatin, and Oxaliplatin. Changes on cell surface and ultrastructure were detected by scanning (SEM) and

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Elliott, Patrick S., Soraeya S. Kharaty, and Catherine M. Phillips. "Plant-Based Diets and Lipid, Lipoprotein, and Inflammatory Biomarkers of Cardiovascular Disease: A Review of Observational and Interventional Studies." Nutrients 14, no. 24 (December 17, 2022): 5371. http://dx.doi.org/10.3390/nu14245371.

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Plant-based diets (PBDs) are becoming increasingly popular. Thus far, the literature has focused on their association with lipid profiles, with less investigation of lipoprotein and inflammatory profiles. Because pro-atherogenic lipid, lipoprotein, and inflammatory processes may facilitate the development of atherosclerosis, understanding the relation between PBDs and these processes is important to inform risk mitigation strategies. Therefore, the objective of this paper was to review the literature on PBDs and lipid, lipoprotein, and inflammatory biomarkers of cardiovascular disease (CVD). A

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Low, M. J. D., and C. Morterra. "Infrared Surface Studies of Opaque or Scattering Materials Using Photothermal Beam Deflection Spectroscopy." Adsorption Science & Technology 2, no. 2 (June 1985): 131–50. http://dx.doi.org/10.1177/026361748500200206.

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Infrared (IR) photothermal beam deflection spectroscopy (PBDS) is briefly described and some of its applications to studies of carbons and highly scattering materials are reviewed. PBDS is especially useful for the study of materials which absorb IR radiation very strongly or act as strong IR scatterers, so that conventional IR techniques fail. Application of PBDS to study the thermal degradation of a phenol-formaldehyde resin, the reaction of NH3 and H2O with the surfaces of intermediate-temperature chars, the effect of Fe3+ on the charring of cellulose, the dehydration of titanyl sulphate, a

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Austin, Grace, Jessica J. A. Ferguson, and Manohar L. Garg. "Effects of Plant-Based Diets on Weight Status in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials." Nutrients 13, no. 11 (November 16, 2021): 4099. http://dx.doi.org/10.3390/nu13114099.

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Excessive adiposity is a major risk factor for type 2 diabetes (T2D), and dietary patterns are important determinants of weight status. Plant-based dietary patterns (PBDs) are known for their therapeutic effects on T2D. The aim is to systematically review RCTs to investigate the effects of various PBDs compared to regular meat-eating diets (RMDs), in individuals who normally consume a RMD on body weight, BMI, and waist circumference in T2D. RCTs investigating PBDs and body weight, BMI, WC for ≥6 weeks in adults with T2D since 1980 were eligible for inclusion. Seven trials (n = 269) were includ

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Gibbs, Joshua, and Francesco P. Cappuccio. "Plant-Based Dietary Patterns for Human and Planetary Health." Nutrients 14, no. 8 (April 13, 2022): 1614. http://dx.doi.org/10.3390/nu14081614.

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The coronavirus pandemic has acted as a reset on global economies, providing us with the opportunity to build back greener and ensure global warming does not surpass 1.5 °C. It is time for developed nations to commit to red meat reduction targets and shift to plant-based dietary patterns. Transitioning to plant-based diets (PBDs) has the potential to reduce diet-related land use by 76%, diet-related greenhouse gas emissions by 49%, eutrophication by 49%, and green and blue water use by 21% and 14%, respectively, whilst garnering substantial health co-benefits. An extensive body of data from pr

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Vitetta, Luis, and Avni Sali. "Primary Bile Duct Stones and Bacterial Activity." HPB Surgery 6, no. 1 (January 1, 1992): 23–33. http://dx.doi.org/10.1155/1992/81017.

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The results of this study suggest that infection with beta-glucuronidase active bacteria is the initial event in the nucleation of primary bile duct stones (PBDS).PBDS from five patients were morphologically fragile and “earthy” with alternating light and dark brown pigment layers with no evidence of a distinct central nucleus that may have been reminiscent of a different structure. Chemically, calcium bilirubinate and calcium palmitate were prominent throughout their structure. All bile duct biles had a positive culture and were always associated with at least one bacterial species which was

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Abe, Yuichi, Masanori Honsho, Ryota Itoh, Ryoko Kawaguchi, Masashi Fujitani, Kazushirou Fujiwara, Masaaki Hirokane, et al. "Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum." Life Science Alliance 1, no. 6 (December 2018): e201800062. http://dx.doi.org/10.26508/lsa.201800062.

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Peroxisome biogenesis disorders (PBDs) manifest as neurological deficits in the central nervous system, including neuronal migration defects and abnormal cerebellum development. However, the mechanisms underlying pathogenesis remain enigmatic. Here, to investigate how peroxisome deficiency causes neurological defects of PBDs, we established a new PBD model mouse defective in peroxisome assembly factor Pex14p, termed Pex14ΔC/ΔC mouse. Pex14ΔC/ΔC mouse manifests a severe symptom such as disorganization of cortical laminar structure and dies shortly after birth, although peroxisomal biogenesis an

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Havali, Cengiz, Sevil Dorum, Yılmaz Akbaş, Orhan Görükmez, and Tugba Hirfanoglu. "Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation." Journal of Pediatric Endocrinology and Metabolism 33, no. 3 (March 26, 2020): 437–41. http://dx.doi.org/10.1515/jpem-2019-0194.

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AbstractBackgroundPeroxisomal biogenesis disorders (PBDs) include a miscellaneous group of diseases which cause serious multisystem disease. Mutations of 13 different PEX genes lead to PBDs including Zellweger syndrome (ZS). Different types of mutations of PEX1 and PEX10 genes are correlated with broad-range phenotypes of PBDs.Case presentationPatient 1 is a 4-month-old boy who was affected by myoclonic seizures, poor oral feeding since birth. The patient was hypotonic and had hepatosplenomegaly. Patient 2 is a 2-month-old boy who presented with decreased movement, severe hypotonia and failure

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Xiong, Wei, Jun Ouyang, Hai Ci, Wenping Jiang, Wei Han, Yu Fu, and Peigang Tian. "The predictive value of serum neopterin for multiple organ dysfunction syndrome in severe burn patients." Pteridines 29, no. 1 (December 31, 2018): 196–200. http://dx.doi.org/10.1515/pteridines-2018-0019.

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AbstractObjective To investigate the predictive value of serum neopterin for multiple organ dysfunction syndrome (MODS) in severe burn patients. Methods Seventy-six severe burn patients with burns covering a total body surface area (TBSA) above 70% were included in this study. Of the 76 patients, 29 cases developed MODS (MODS group) and the remaining 47 subjects did not (non-MODS group). From the MODS group, 12 patients died (Death group) and 17 patients survived (Survive group). The serum level of neopterin in the MODS and non-MODS groups were examined by radioimmunoassay on following 1, 3 ,

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TAMURA, Shigehiko, Naomi MATSUMOTO, Atsushi IMAMURA, Nobuyuki SHIMOZAWA, Yasuyuki SUZUKI, Naomi KONDO, and Yukio FUJIKI. "Phenotype–genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p–Pex6p interaction." Biochemical Journal 357, no. 2 (July 9, 2001): 417–26. http://dx.doi.org/10.1042/bj3570417.

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The peroxisome biogenesis disorders (PBDs), including Zellweger syndrome (ZS), neonatal adrenoleucodystrophy (NALD) and infantile Refsum disease (IRD), are fatal autosomal recessive diseases caused by impaired peroxisome biogenesis, of which 12 genotypes have been reported. ZS patients manifest the severest clinical and biochemical abnormalities, whereas those with NALD and IRD show less severity and the mildest features respectively. We have reported previously that temperature-sensitive peroxisome assembly is responsible for the mildness of the clinical features of IRD. PEX1 is the causative

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Fujiki, Yukio, Non Miyata, Naomi Matsumoto, and Shigehiko Tamura. "Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p involved in shuttling of the PTS1 receptor Pex5p in peroxisome biogenesis." Biochemical Society Transactions 36, no. 1 (January 22, 2008): 109–13. http://dx.doi.org/10.1042/bst0360109.

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The peroxisome is a single-membrane-bound organelle found in eukaryotes. The functional importance of peroxisomes in humans is highlighted by peroxisome-deficient PBDs (peroxisome biogenesis disorders), such as Zellweger syndrome. Two AAA (ATPase associated with various cellular activities) peroxins, Pex1p and Pex6p, are encoded by PEX1 and PEX6, the causal genes for CG (complementation group) 1 and CG4 PBDs respectively. PEX26, which is responsible for CG8 PBDs, codes for Pex26p, the recruiter of Pex1p–Pex6p complexes to peroxisomes. We recently assigned the binding regions between human Pex1

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Janata, J., Z. Kamenik, R. Gazak, S. Kadlcik, and L. Najmanova. "Biosynthesis and incorporation of an alkylproline-derivative (APD) precursor into complex natural products." Natural Product Reports 35, no. 3 (2018): 257–89. http://dx.doi.org/10.1039/c7np00047b.

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Niu, Xing, Boris Glavic, Ziyu Liu, Pengyuan Li, Dieter Gawlick, Vasudha Krishnaswamy, Zhen Hua Liu, and Danica Porobic. "Provenance-based data skipping." Proceedings of the VLDB Endowment 15, no. 3 (November 2021): 451–64. http://dx.doi.org/10.14778/3494124.3494130.

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Database systems use static analysis to determine upfront which data is needed for answering a query and use indexes and other physical design techniques to speed-up access to that data. However, for important classes of queries, e.g., HAVING and top-k queries, it is impossible to determine up-front what data is relevant. To overcome this limitation, we develop provenance-based data skipping (PBDS), a novel approach that generates provenance sketches to concisely encode what data is relevant for a query. Once a provenance sketch has been captured it is used to speed up subsequent queries. PBDS

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17

Varlashkin, P. G., and M. J. D. Low. "FT-IR Photothermal Beam Deflection Spectroscopy of Black Inks on Paper." Applied Spectroscopy 40, no. 4 (May 1986): 507–13. http://dx.doi.org/10.1366/0003702864508999.

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Infrared spectra of several different black inks on paper were obtained by FT-IR photothermal beam deflection spectroscopy (PBDS). Even though the manuscript samples contained about 0.1–0.5 μg of ink solid, spectra of sufficient quality were obtained to enable us to tell which inks contain carbon and to permit some differentiation between similar black inks to be made. However, the identification of an unknown ink is not feasible at present. Spectra of the ink printed on two stamps, and of the black print of a dollar bill, were also recorded. IR/PBDS studies of manuscript and print are totally

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Muñoz-Pujol, Gerard, Socorro Alforja-Castiella, Ricardo Casaroli-Marano, Blai Morales-Romero, Judit García-Villoria, Vicente A. Yépez, Julien Gagneur, et al. "Diagnostic Odyssey in an Adult Patient with Ophthalmologic Abnormalities and Hearing Loss: Contribution of RNA-Seq to the Diagnosis of a PEX1 Deficiency." International Journal of Molecular Sciences 23, no. 20 (October 15, 2022): 12367. http://dx.doi.org/10.3390/ijms232012367.

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Peroxisomal biogenesis disorders (PBDs) are a heterogeneous group of genetic diseases. Multiple peroxisomal pathways are impaired, and very long chain fatty acids (VLCFA) are the first line biomarkers for the diagnosis. The clinical presentation of PBDs may range from severe, lethal multisystemic disorders to milder, late-onset disease. The vast majority of PBDs belong to Zellweger Spectrum Disordes (ZSDs) and represents a continuum of overlapping clinical symptoms, with Zellweger syndrome being the most severe and Heimler syndrome the less severe disease. Mild clinical conditions frequently p

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Abe, Yuichi, Masanori Honsho, Ryoko Kawaguchi, Takashi Matsuzaki, Yayoi Ichiki, Masashi Fujitani, Kazushirou Fujiwara, et al. "A peroxisome deficiency–induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway." Journal of Biological Chemistry 295, no. 16 (March 12, 2020): 5321–34. http://dx.doi.org/10.1074/jbc.ra119.011989.

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The peroxisome is a subcellular organelle that functions in essential metabolic pathways, including biosynthesis of plasmalogens, fatty acid β-oxidation of very-long-chain fatty acids, and degradation of hydrogen peroxide. Peroxisome biogenesis disorders (PBDs) manifest as severe dysfunction in multiple organs, including the central nervous system (CNS), but the pathogenic mechanisms in PBDs are largely unknown. Because CNS integrity is coordinately established and maintained by neural cell interactions, we here investigated whether cell-cell communication is impaired and responsible for the n

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20

Chin, James. "PBDS and ethnicity in Sarawak politics." Journal of Contemporary Asia 26, no. 4 (January 1996): 512–26. http://dx.doi.org/10.1080/00472339680000311.

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Gong, Xiaoyan, Xien Gui, Yuxia Zhang, and Po Tien. "Screening for CD8 cytotoxic T lymphocytes specific for Gag of human immunodeficiency virus type 1 subtype B′ Henan isolate from China and identification of novel epitopes restricted by the HLA-A2 and HLA-A11 alleles." Journal of General Virology 87, no. 1 (January 1, 2006): 151–58. http://dx.doi.org/10.1099/vir.0.81335-0.

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The human immunodeficiency virus type 1 (HIV-1) epidemic in China is increasing rapidly at an irrepressible rate. It is caused by HIV-1 subtype B′ in central China. After the full-length genome sequencing of the Henan isolate was performed, the definition of optimal cytotoxic T-lymphocyte (CTL) epitopes across the Henan isolate genome has become crucial for vaccine design. In this study, by using ELISPOT assays with synthetic peptides corresponding to the sequence of the Henan isolate, the identification and analysis of Gag-specific CTL responses among 28 treated and 26 untreated infected paid

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Schauvliege, Hans, Marc Du Bois, and Jan Verlooy. "Implant failure following pedicle based dynamic stabilization of the lumbar spine." Acta Orthopaedica Belgica 87, no. 1 (March 31, 2021): 191–96. http://dx.doi.org/10.52628/87.1.24.

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Pedicle-based dynamic stabilization (PBDS) devices such as Dynesys are promoted as an alternative and less invasive option for rigid stabilization of one and even more levels of the lumbar spine. Promising features of the Dynesys system, as well as shortcomings, became obvious in several clinical studies. Since 2012, we started using a new PBDS device as an alternative for the Dynesys, to avoid the screw loosening and the kyphosing effect. The objective is to compare failure rates between the Dynesys and Balan-C type PBDS implant and factors affecting outcome. In a retrospective study we inves

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Jiang, Jianqing, and Reqiang Liu. "Effect of Improvement and Application of Composite Prefabricated Vertical Drain Method in Marine Soft Ground: A Case Study." Advances in Civil Engineering 2019 (June 12, 2019): 1–18. http://dx.doi.org/10.1155/2019/6097504.

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One of the commonly used techniques to improve marine soft ground is the drainage consolidation method by plastic board drains (PBDs). But some complex marine soft ground will cause construction inconvenience of PBDs in certain areas of these sites, thus affecting the improvement effect. An alternative possible approach to overcoming these deficiencies may be the combination of PBDs and sand wick drains (SWDs) (i.e., composite prefabricated vertical drains (CPVDs)) as vertical drainage channels in the same site. In order to verify the suitability and performance of this method in marine soft g

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Vitetta, Luis, Avni Sali, Peter Little, Jack Nayman, and Ayman Elzarka. "Primary “Brown Pigment” Bile Duct Stones." HPB Surgery 4, no. 3 (January 1, 1991): 209–22. http://dx.doi.org/10.1155/1991/76160.

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Bile duct stones from 42 patients were morphologically and chemically analysed. The calculi from 27 patients had important primary bile duct stone (PBDS) features, consisting of a general ovoid shape and fragile structure, with alternating light and dark brown pigmented layers on cross-section. Chemically these stones contained low levels of cholesterol, with high levels of bilirubin and calcium. Subsequent infrared spectroscopy analysis showed that calcium bilirubinate and calcium palmitate were the only calcium salts present. Calcium palmitate was prominent in the light brown layers. A morph

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Bennett, Frank E., Yanxun Chang, Gennian Ge, and Malcolm Greig. "Existence of (v,{5,w∗},1)-PBDs." Discrete Mathematics 279, no. 1-3 (March 2004): 61–105. http://dx.doi.org/10.1016/s0012-365x(03)00262-0.

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Bennett, F. E., and J. Yin. "Some results on (v,{5,w*})-pbds." Journal of Combinatorial Designs 3, no. 6 (1995): 455–68. http://dx.doi.org/10.1002/jcd.3180030609.

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Fazlollahi, Narges, Amir Anushiravani, Maryam Rahmati, Mohammad Amani, Hossein Asl-Soleimani, Melineh Markarian, Alice Chu Jiang, and Javad Mikaeli. "Safety and Efficacy of Graded Gradual Pneumatic Balloon Dilation in Idiopathic Achalasia Patients: A 24-Year Single-Center Experience." Archives of Iranian Medicine 24, no. 12 (December 1, 2021): 862–68. http://dx.doi.org/10.34172/aim.2021.129.

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Background: Pneumatic balloon dilation (PBD) is a first line treatment for idiopathic achalasia. Here we report the safety and efficacy of graded gradual PBD on short and long-term follow-up. Methods: We evaluated 1370 idiopathic achalasia patients over a period of 24 years (1994-2018), prospectively. 216 patients did not undergo PBD due to comorbid diseases. Ultimately, 1092 achalasia patients were enrolled. All patients underwent graded gradual PBD, with repeat dilation if symptoms relapsed. Response to treatment was evaluated by Vantrappen scoring system. Results: Of 1092 achalasia patients

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Liu, Tian-yuan, Dan Huang, Peng-Yuan Xu, Bo Lu, Zhi-Chao Zhen, Wei-Zhen Zheng, Xiao Li, Ge-Xia Wang, and Junhui Ji. "Study on composting and seawater degradation properties of diethylene glycol-modified poly(butylene succinate) copolyesters." e-Polymers 22, no. 1 (January 1, 2022): 615–26. http://dx.doi.org/10.1515/epoly-2022-0057.

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Abstract The marine pollution caused by traditional plastics is becoming increasingly serious, and the fundamental way to solve this problem is to look for plastic substitutes that can degrade in the marine environment. Herein, a series of high-molecular-weight poly(butylene succinate-co-diethylene glycol succinate) (PBDS) was obtained by the introduction of low-cost diethylene glycol (DEG) into the main chain of poly(butylene succinate) (PBS), which aimed to obtain the materials that can be degraded both in compost and seawater. The research showed that the increase in the DEG content reduced

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Marrone, Giulia, Cristina Guerriero, Daniela Palazzetti, Paolo Lido, Alessandro Marolla, Francesca Di Daniele, and Annalisa Noce. "Vegan Diet Health Benefits in Metabolic Syndrome." Nutrients 13, no. 3 (March 2, 2021): 817. http://dx.doi.org/10.3390/nu13030817.

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Plant-based diets (PBDs) are increasingly consumed by the Italian population and around the world. In particular, among PBDs, the vegan diet is a food pattern characterized by the exclusion of all animal-origin foods. What drives people to adopt this model are mainly ethical, health and environmental reasons. A vegan diet, if well-balanced and varied, can help in achieving and maintaining an optimal state of health. However, this nutritional approach, if not well-balanced, can cause deficiencies in proteins, ω-3 fatty acids, iron, vitamin D and calcium, zinc, iodine and, above all, vitamin B12

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Han, Ho-Sik, Sun-Yeo Mun, and Cheol-Hong Hwang. "Effects of User Dependence on the Prediction Results of Visibility in Fire Simulations." Fire Science and Engineering 35, no. 3 (June 30, 2021): 14–22. http://dx.doi.org/10.7731/kifse.b5e493d9.

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To improve the reliability of safety assessments in domestic performance-based designs (PBDs), the problem of the input parameters being dependent on fire-simulation users was quantitatively analyzed. Thus, the results of statistical analyses of domestic PBD reports evaluated over the last 5 years were examined. It was determined that the uncertainties of the input parameters might have a relatively larger influence on the statistical deviations than the measurement uncertainties. Accordingly, a sensitivity analysis was performed by considering the statistical deviations of the input parameter

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Li, Wei, ShenChieh Chou, Ankush Khullar, and Barbara Gerratana. "Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog." Applied and Environmental Microbiology 75, no. 9 (March 6, 2009): 2958–63. http://dx.doi.org/10.1128/aem.02325-08.

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ABSTRACT Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.

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Li, Wei, Ankush Khullar, ShenChieh Chou, Ashley Sacramo, and Barbara Gerratana. "Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic." Applied and Environmental Microbiology 75, no. 9 (March 6, 2009): 2869–78. http://dx.doi.org/10.1128/aem.02326-08.

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ABSTRACT Pyrrolobenzodiazepines, a class of natural products produced by actinomycetes, are sequence selective DNA alkylating compounds with significant antitumor properties. Among the pyrrolo[1,4]benzodiazepines (PBDs) sibiromycin, one of two identified glycosylated PBDs, displays the highest affinity for DNA and the most potent antitumor properties. Despite the promising antitumor properties clinical trials of sibiromycin were precluded by the cardiotoxicity effect in animals attributed to the presence of the C-9 hydroxyl group. As a first step toward the development of sibiromycin analogs,

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Abel, R. Julian R., Gennian Ge, Malcolm Greig, and Alan C. H. Ling. "Further results on (v,{5,w∗},1)-PBDs." Discrete Mathematics 309, no. 8 (April 2009): 2323–39. http://dx.doi.org/10.1016/j.disc.2008.05.008.

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Moreira, Tailane Sant´Anna, Valéria Pereira De Sousa, and Maria Bernadete Riemma Pierre. "Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 2 (August 24, 2010): 286. http://dx.doi.org/10.18433/j34880.

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Abstract PURPOSE: Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetration enhancer, on the in vitro release of LM from poloxamer-based delivery systems (PBDS). The rheological behavior (shear rate dependent viscosity) and gelation temperature through measurements of optimal sol-gel transition temperatures (Tsol-gel) were also carried out in these systems. METHO

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Xu, Guodong, Lie Chen, Hui Lei, Zhihui Liao, Nan Yi, Jinliang Liu, and Yiwang Chen. "A novel alkylsilyl-fused copolymer-based non-fullerene solar cell with over 12% efficiency." Journal of Materials Chemistry A 7, no. 8 (2019): 4145–52. http://dx.doi.org/10.1039/c8ta12224e.

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A new alkylsilyl-fused copolymer PBDS-TZ unit was developed as donor material for polymer solar cells. When blended with IT-4F, an appropriate micromorphology with vertical component distribution in active layer was obtained. A notably PCE of 12.01% with a high FF of 73.1% and J<sub>SC</sub> of 20.45 mA cm<sup>−2</sup> for the devices.

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Rahman, Khondaker M., David B. Corcoran, Tam T. T. Bui, Paul J. M. Jackson, and David E. Thurston. "Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes." PLoS ONE 9, no. 8 (August 18, 2014): e105021. http://dx.doi.org/10.1371/journal.pone.0105021.

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Brucoli, Federico. "DNA-Minor Groove Binding Agents as Anti-Tubercular Probes. Old Tools for a New Challenge?" Anti-Infective Agents 16, no. 2 (August 3, 2018): 71–79. http://dx.doi.org/10.2174/2211352516666180612080830.

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Tuberculosis, an ancient infectious disease caused by Mycobacterium tuberculosis, ranks as one of the top ten killers worldwide. The limited number of validated targets and scarce therapeutic options demand that renewed efforts should be made to identify tuberculosis drugs with novel mechanisms of action. To this end, mycobacterial DNA might represent a potential target for the development of effective anti-tubercular compounds. In particular, the minor groove of DNA offers an important recognition site for small-molecules that can be programmed to bind to this region in a sequence-selective m

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Bülow, Margret H., Christian Wingen, Deniz Senyilmaz, Dominic Gosejacob, Mariangela Sociale, Reinhard Bauer, Heike Schulze, et al. "Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants." Molecular Biology of the Cell 29, no. 4 (February 15, 2018): 396–407. http://dx.doi.org/10.1091/mbc.e17-08-0535.

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Inherited peroxisomal biogenesis disorders (PBDs) are characterized by the absence of functional peroxisomes. They are caused by mutations of peroxisomal biogenesis factors encoded by Pex genes, and result in childhood lethality. Owing to the many metabolic functions fulfilled by peroxisomes, PBD pathology is complex and incompletely understood. Besides accumulation of peroxisomal educts (like very-long-chain fatty acids [VLCFAs] or branched-chain fatty acids) and lack of products (like bile acids or plasmalogens), many peroxisomal defects lead to detrimental mitochondrial abnormalities for un

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Mastalski, Thomas, Rebecca Brinkmeier, and Harald W. Platta. "The Peroxisomal PTS1-Import Defect of PEX1- Deficient Cells Is Independent of Pexophagy in Saccharomyces cerevisiae." International Journal of Molecular Sciences 21, no. 3 (January 29, 2020): 867. http://dx.doi.org/10.3390/ijms21030867.

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The important physiologic role of peroxisomes is shown by the occurrence of peroxisomal biogenesis disorders (PBDs) in humans. This spectrum of autosomal recessive metabolic disorders is characterized by defective peroxisome assembly and impaired peroxisomal functions. PBDs are caused by mutations in the peroxisomal biogenesis factors, which are required for the correct compartmentalization of peroxisomal matrix enzymes. Recent work from patient cells that contain the Pex1(G843D) point mutant suggested that the inhibition of the lysosome, and therefore the block of pexophagy, was beneficial fo

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Picconi, Pietro, Charlotte K. Hind, J. Mark Sutton, and Khondaker Miraz Rahman. "Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines." Antibiotics 11, no. 12 (December 7, 2022): 1770. http://dx.doi.org/10.3390/antibiotics11121770.

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It is urgent to find new antibiotic classes against multidrug-resistant bacteria as the rate of discovery of new classes of antibiotics has been very slow in the last 50 years. Recently, pyrrolobenzodiazepines (PBDs) with a C8-linked aliphatic-heterocycle have been identified as a new broad-spectrum antibiotic class with activity against Gram-negative bacteria. The active imine moiety of the reported lead pyrrolobenzodiazepine compounds was replaced with amide to obtain the non-DNA binding and noncytotoxic dilactam analogues to understand the structure-activity relationship further and improve

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Antonow, Dyeison, and David E. Thurston. "Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)." Chemical Reviews 111, no. 4 (December 17, 2010): 2815–64. http://dx.doi.org/10.1021/cr100120f.

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Basher, Mohammad A., Khondaker Miraz Rahman, Paul J. M. Jackson, David E. Thurston, and Keith R. Fox. "Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA." Biophysical Chemistry 230 (November 2017): 53–61. http://dx.doi.org/10.1016/j.bpc.2017.08.006.

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Shao, Mingwu, Jie Jiang, Ming Li, Lijie Wu, and Mingzhu Hu. "Recent developments in the analysis of polybrominated diphenyl ethers and polybrominated biphenyls in plastic." Reviews in Analytical Chemistry 35, no. 3 (September 1, 2016): 133–43. http://dx.doi.org/10.1515/revac-2016-0012.

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AbstractPolybrominated diphenyl ethers (PBDEs) and polybrominated biphenyls (PBBs), heavily used as flame retardant in plastics, are harmful to environment and human health. It is of great importance for method development to determine PBDEs and PBBs in plastics. A review of developments on the analysis of PBDEs and PBBs in plastics is presented in this paper. The analytical procedures including sample pretreatment, extraction, clean-up/fractionation, and detection are carefully discussed. The drawbacks and merits of each method are summarized. The aim of this review is to improve the analytic

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Varlashkin, P. G., and M. J. D. Low. "Infrared Spectra of Intumescent Chars." Applied Spectroscopy 40, no. 3 (March 1986): 393–97. http://dx.doi.org/10.1366/0003702864509141.

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The utility of infrared Fourier transform photothermal beam deflection spectroscopy (PBDS) for the examination of intumescent systems was explored. Infrared spectra were recorded of a model system consisting of a mixture of pentaerythritol and (NH4)2HPO4, and of a film of a commercial fire-retardant paint painted on sheet metal, at various stages before, at, and after intumescence. Although the morphology of the materials changes greatly during the thermal decompositions, infrared spectra can be recorded which can provide useful information about the systems and intumescent chars.

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Wang, Shuai, Jiacheng Yang, Beiyu Zhang, Kuntan Wu, Ao Yang, Chong Li, Jiacai Zhang, et al. "Deoxynivalenol Impairs Porcine Intestinal Host Defense Peptide Expression in Weaned Piglets and IPEC-J2 Cells." Toxins 10, no. 12 (December 15, 2018): 541. http://dx.doi.org/10.3390/toxins10120541.

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Host defense peptides (HDPs) are efficient defense components of the innate immune system, playing critical roles in intestinal homeostasis and protection against pathogens. This study aims to investigate the interference effects of DON on the intestinal porcine HDPs expression in piglets and intestinal porcine epithelial cell line (IPEC-J2) cells, and elucidate the underlying mechanisms through which it functions. In an animal experiment, intestinal HDPs were determined in weaned piglets fed control and 1.28 mg/kg or 2.89 mg/kg DON-contaminated diets. Dietary exposure to DON significantly dec

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Cooper, Nectaroula, David R. Hagan, Arnaud Tiberghien, Temitope Ademefun, Charles S. Matthews, Philip W. Howard, and David E. Thurston. "Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents." Chemical Communications, no. 16 (July 15, 2002): 1764–65. http://dx.doi.org/10.1039/b205136b.

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Low, M. J. D. "Some Practical Aspects of FT-IR/PBDS Part I: Vibrational Noise." Applied Spectroscopy 40, no. 7 (September 1986): 1011–19. http://dx.doi.org/10.1366/0003702864508052.

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FT-IR photothermal beam deflection (PBD) signals are several orders of magnitude smaller than PBD signals generated in other spectral regions and by other means, so that vibrational rather than electronic noise is important to the production of FT-IR/PBD spectra at present. The interferometer of the PBD spectrometer produces mechanical vibrations, but the most serious disturbances arise in the environment and are of unknown origin and uncontrollable. The mechanical vibrations imposed on the optics lead to random, broad-band noise which can be decreased by multiple scanning, as well as to noise

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Pavagadhi, Shruti, and Sanjay Swarup. "Metabolomics for Evaluating Flavor-Associated Metabolites in Plant-Based Products." Metabolites 10, no. 5 (May 15, 2020): 197. http://dx.doi.org/10.3390/metabo10050197.

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Plant-based diets (PBDs) are associated with environmental benefits, human health promotion and animal welfare. There is a worldwide shift towards PBDs, evident from the increased global demand for fresh plant-based products (PBPs). Such shifts in dietary preferences accompanied by evolving food palates, create opportunities to leverage technological advancements and strict quality controls in developing PBPs that can drive consumer acceptance. Flavor, color and texture are important sensory attributes of a food product and, have the largest influence on consumer appeal and acceptance. Among t

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Low, M. J. D., and C. Morterra. "Some Practical Aspects of FT-IR/PBDS. Part II: Sample Handling Procedures." Applied Spectroscopy 41, no. 2 (February 1987): 280–87. http://dx.doi.org/10.1366/000370287774986813.

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FT-IR photothermal beam deflection spectroscopy (PBDS) is truly nondestructive in that none of the sample preparation methods needed for the IR examination of solids are mandated. Such nondestructive examination is, however, inefficient—in that long scanning times are frequently needed—and is not really required with many samples. If it is permissible to subject the sample to a simple hand grinding, efficiency can be greatly improved. Sample preparation and handling are discussed, and the peculiarities of certain samples are described. Particular emphasis is placed on the necessity of proper s

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Genuis, Shelagh K., Detlef Birkholz, and Stephen J. Genuis. "Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study." BioMed Research International 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/3676089.

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Commonly used as flame retardants, polybrominated diphenyl ethers (PBDEs) are routinely detected in the environment, animals, and humans. Although these persistent organic pollutants are increasingly recognized as having serious health implications, particularly for children, this is the first study, to our knowledge, to investigate an intervention for human elimination of bioaccumulated PBDEs. Objectives. To determine the efficacy of blood, urine, and perspiration as PBDE biomonitoring mediums; assess excretion of five common PBDE congeners (28, 47, 99, 100, and 153) in urine and perspiration

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