Log in

Relevant bibliographies by topics / PBpa / Dissertations / Theses

To see the other types of publications on this topic, follow the link: PBpa.

Dissertations / Theses on the topic 'PBpa'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'PBpa.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Braxton, Courtney N. "The progress on mapping ubiquitin signaling using photocrosslinking mono and di-ubiquitin probes and other ubiquitin moieties." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5382.

Full text

Abstract:

Ubiquitin (Ub) is a small, 76 amino acid, and post-translational modification (PTM) protein in eukaryotes. Modification of a substrate protein via the covalent attachment of the C-terminal glycine of Ub to the ε-amino group of lysine residues in a substrate is termed ubiquitination. Unlike, other PTM proteins, Ub can form polyUb chains at one or more of its seven lysine residues. (K6, K11, K27, K29, K33, K48, and K68). The consequence of these different polymerization sites is altered biological response with different polyUb linkages conferring different fates to target proteins. Unfortunat

APA, Harvard, Vancouver, ISO, and other styles

2

Wei, Yuping. "Characterization of two Bacillus subtilis penicillin-binding protein-coding genes, ykuA (pbpH) and yrrR (pbpI)." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34900.

Full text

Abstract:

<p> Penicillin-binding proteins (PBPs) are required in the synthesis of the cell wall of bacteria. In Bacillus subtilis, PBPs play important roles in the life cycle, including both vegetative growth and sporulation, and contribute to the formation of the different structures of vegetative cell wall and spore cortex. The B. subtilis genome sequencing project revealed there were two uncharacterized genes, ykuA and yrrR, with extensive sequence similarity to class B PBPs. These two genes are renamed and referred to henceforth as pbpH and pbpI, respectively. </p><p>A sequence alignment of the pred

APA, Harvard, Vancouver, ISO, and other styles

3

Paulin, S. "Impact of epicatechin gallate on the structural integrity of the PBP2/PBP2a complex in methicillin resistant Staphylococcus aureus." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1434251/.

Full text

Abstract:

Introduction: The selective pressure imposed by the misuse and overuse of antibiotics has led to the emergence and dissemination of methicillin resistant Staphylococcus aureus (MRSA), forcing a re-evaluation of therapeutic approaches to the treatment of MRSA infections. Epicatechin gallate (ECg), a constituent of the tea plant Camellia sinensis, has the capacity to abrogate the resistance of MRSA to β-lactam antibiotics and may be useful as an adjunct to conventional chemotherapy. Current evidence suggests that ECg sensitises resistant strains to β-lactam agents by disruption of the penicillin

APA, Harvard, Vancouver, ISO, and other styles

4

Stöckl, Stefanie. "Modellierung PBPK-relevanter Verteilungskoeffizienten organischer Stoffe." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2014. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-131508.

Full text

Abstract:

Drei Verteilungskoeffizienten, die für physiologie-basierte Pharmakokinetik (PBPK)-Modelle relevant sind, wurden mit verschiedenen Ansätzen modelliert. Für den Blut/Luft-Verteilungskoeffizienten wurde ein auf linearen Solvatations-Energie-Beziehungen (LSER) beruhendes Literaturmodell angewendet und diskutiert. Mit einer schematischen Aufteilung des Blutkompartiments in Wasser und einen organischen Teil wurde der Blut/Luft-Verteilungskoeffizient mit einer linearen Regression von anderen Verteilungskoeffizienten vorhergesagt. Zusätzlich wurde ein Fragmentmodell entwickelt. Der Fett/Luft-Verteilu

APA, Harvard, Vancouver, ISO, and other styles

5

Gómez, Serrano Amalia. "Studies on pbp2 of Staphylococcus aureus." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624442.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Bøe, Andreas Gagnat. "Degradation and Stability of PBCA and POCA Nanoparticles." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for fysikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22417.

Full text

Abstract:

Nanoparticles represent promising carriers for controlled drug delivery. In this project threedifferent intruments: Zetasizer, Nanosight and Gas Chromatography, have been used to detect and analyse degradation of monodisperse poly butylcyanoacrylate (PBCA) and polyoctylcyanoacrylate (POCA) nanoparticles with a mean size diameter of 145 and 155 nm,respectively. It was found that the Nanosight and Gas Chromatography are valuable instrumentsfor detecting and analysing degradation, whereas the Zetasizer turned out to giveunreliable results because of increasing polydispersity in the samples. PBCA

APA, Harvard, Vancouver, ISO, and other styles

7

Alsmadi, Mo'tasem Mohamed. "Physiologically based pharmacokinetic (PBPK) model of Ivermectin (IVM)." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/5906.

Full text

Abstract:

Purpose: Ivermectin (IVM) is a lipophilic BCS-II compound (molecular weight=875 g/mole, LogP=3.22, intrinsic solubility=700 ug/L). IVM is used as antiparasitic drug in both humans and animals. IVM is known to have a half-life of 12-56 hours in humans. Strongyloidiasis is a chronic parasitic infection of humans caused by Strongyloides stercoralis, with an estimated 30-100 million people infected worldwide. Infection may be severe and even life-threatening in cases of immunodeficiency. Patients with disseminated strongyloidiasis are usually bedridden hospitalized patients that show symptoms such

APA, Harvard, Vancouver, ISO, and other styles

8

Gulhan, Doga C. (Doga Can). "Properties of dijets in pp, pPb and PbPb collisions." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104504.

Full text

Abstract:

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 217-232).<br>Two dijet measurements, one using 35 pb-¹ pPb data at [square root]sNN- 5.02 TeV, and another with 166 [mu]b-¹ PbPb and 5.3 pb-¹ pp data at [square root]sNN = 2.76 TeV collected with CMS detector at the LHC, are presented. In pPb collisions, the dijet PT ratios, azimuthal angle differences and pseudorapidity distributions are measured and compared to PYTHIA and PYTHIA+HIJING simulations as well as NLO QCD predict

APA, Harvard, Vancouver, ISO, and other styles

9

Abass, Abdul-Kariem. "Electrical and optical studies of lead phthalocynanine (PbPc) thin films." Thesis, Lancaster University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239800.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Mororó, Janio da Silva. "Estudo de marcação do anticorpo monoclonal anti-PBP2a com 99mTc." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-06032013-151412/.

Full text

Abstract:

Staphylococcus aureus é um dos principais microorganismos causadores de infecção em humanos, podendo causar inclusive bacteremia e endocardite nos indivíduos infectados. Diversas cepas desta bactéria apresentam resistência a diferentes tipos de antibióticos, dentre eles os antibióticos meticilina e amoxicilina, como no caso da bactéria Staphylococcus aureus resistente à meticilina (MRSA). A Proteína ligadora de Penicilina 2a (PBP2a) é a enzima responsável por conferir resistência para a MRSA aos antibióticos β-lactâmicos, sendo uma molécula promissora para terapia com AcM. No entanto, alé

APA, Harvard, Vancouver, ISO, and other styles

11

Salem, Farzaneh. "Applications of physiologically based pharmacokinetic modelling to prediction of the likelihood of metabolic drug interactions in paediatric population and studying disparities in pharmacokinetics between children and adults." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/applications-of-physiologically-based-pharmacokinetic-modelling-to-prediction-of-the-likelihood-of-metabolic-drug-interactions-in-paediatric-population-and-studying-disparities-in-pharmacokinetics-between-children-and-adults(1fdefe9a-037a-4738-b92a-5904a60960db).html.

Full text

Abstract:

Anticipation of drug-drug interactions (DDIs) in the paediatric population are merely based on data generated in adults. Hence decision on avoiding certain combinations or attempts to adjust and manage the doses under combination-therapy are mainly speculative from the knowledge of what occurs in adults. However, due to developmental changes in elimination pathways from birth to adolescents, the assumption of DDIs being similar in adults and children might not be correct. This thesis firstly identifies and quantitatively compares the reported DDIs in paediatric and adult populations through a

APA, Harvard, Vancouver, ISO, and other styles

12

Émond, Claude. "Modèle pharmacocinétique à base physiologique (PBPK) pour les composés hautement lipophiles." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ65355.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Kennedy, Penny S., and Joe T. McClure. "Performance-Based Service Acquisition (PBSA) study and graduate level course material." Monterey, California. Naval Postgraduate School, 2005. http://hdl.handle.net/10945/9985.

Full text

Abstract:

Joint Applied Project<br>Approved for public release; distribution is unlimited<br>The purpose of this project is to provide materials and information in the form of lessons that will make up a teachable course for graduate students of the Naval Post Graduate School. In addition, this research will address the current Department of Defense contracting policy, guidance, regulations and lessons learn. Performance-based Service Acquisition (PBSA) within the Department of Defense at both other government agencies, as well as commercial practices at progressive businesses are examined as they relat

APA, Harvard, Vancouver, ISO, and other styles

14

Simão, José Alexandre. "Blendas PBSA/PCL reforçadas com nanowhiskers de celulose enxertados com PCL." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-16102014-094251/.

Full text

Abstract:

O presente trabalho apresenta resultados do estudo que objetivou desenvolver blendas poliméricas compostas por dois polimeros biodegradáveis, o poli (butileno succinato - co - adipato) (PBSA) copolímero de poliésteres alifáticos e a policaprolactona (PCL). O estudo desenvolveu a tecnologia para a incorporação de nanowhiskers de celulose (NWC) enxertados com PCL (NWC - g - PCL), com objetivo de melhorar a adesão nanowhisker/matrix, e otimizar as propriedades mecânicas destes polímeros. As composições utilizadas foram 30PCL/70PBSA e 50PCL/50PBSA (em % de massa), com 1, 3 e 5% de NWC - g - PCL. A

APA, Harvard, Vancouver, ISO, and other styles

15

Mistry, Bhavesh V. "Analysis of SEDS proteins and their cognate PBPs in Streptomyces coelicolor." Thesis, Swansea University, 2008. https://cronfa.swan.ac.uk/Record/cronfa42448.

Full text

Abstract:

The rodA and ftsW genes encode polytopic membrane proteins that are essential for bacterial cell elongation and division, respectively. These genes are highly conserved among bacteria with a peptidoglycan cell wall and belong to the SEDS ("shape, elongation, division, and sporulation") gene family. Each SEDS gene is invariably linked with a cognate class B high-molecular weight penicillin-binding protein (HMW PBP) gene. Four such pairs of genes are found in the genome of filamentous differentiating Streptomyces coelicolor. This study focused on characterization of four SEDS genes [SC02085 (fts

APA, Harvard, Vancouver, ISO, and other styles

16

Ball, Kathryn. "Physiologically based pharmacokinetic modelling of the central nervous system : strategies for drug development." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P630.

Full text

Abstract:

Une étape critique au cours du développement de médicaments est la mesure ou la prédiction des concentrations du médicament dans un tissu cible, qui peuvent ensuite être liées à des mesures de leur efficacité ou leur toxicité. Les concentrations de médicaments ne pouvant être mesurées dans le cerveau humain, ils doivent être simulés ou prédits en utilisant des approches alternatives de modélisation. L'objectif de cette thèse est de développer in silico des approches de prédiction combinant à la fois des données précliniques in vitro et in vivo dans un modèle physiologique structuré, avec une s

APA, Harvard, Vancouver, ISO, and other styles

17

OLIVEIRA, Wagner Luis Mendes de. "Avaliação da patogenicidade e do mecanismo de resistência à meticilina em amostras de Staphylococcus spp." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/13416.

Full text

Abstract:

Submitted by Daniella Sodre (daniella.sodre@ufpe.br) on 2015-04-17T15:34:56Z No. of bitstreams: 2 TESE Wagner Oliveira.pdf: 1211878 bytes, checksum: 2511da52ea7b930ceb06c98d5e740455 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)<br>Made available in DSpace on 2015-04-17T15:34:56Z (GMT). No. of bitstreams: 2 TESE Wagner Oliveira.pdf: 1211878 bytes, checksum: 2511da52ea7b930ceb06c98d5e740455 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2013-02-26<br>FACEPE; CNPq<br>Os estafilococos fazem parte da mic

APA, Harvard, Vancouver, ISO, and other styles

18

Fàbrega, Bonadona Francesc. "Physiologically-Based Pharmacokinetic (Pbpk) Modeling of Pcdd/Fs and Pfass in Humans." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/284035.

Full text

Abstract:

Els models farmacocinètics (PBPK) són representacions matemàtiques del cos humà, que tenen com a objectiu calcular la concentració de compostos químics en els teixits humans. Els models PBPK poden millorar el càlcul del risc per a la salut humana, però de moment no han estat escassament utilitzats. Entre els compostos ambientals més perillosos per a la salut humana destaquen les dibenzo-p-dioxines policlorades i dibenzofurans policlorats (PCDD/Fs) i els compostos perfluorats (PFASs). L’objectiu de la present tesis es el desenvolupament de un model PBPK per calcular la concentració de PCDD/Fs

APA, Harvard, Vancouver, ISO, and other styles

19

Silva, Jorge Fernando Valle. "Estudo da capacidade de imageamento do protótipo do brazilian decimetric array (PBDA)." Instituto Nacional de Pesquisas Espaciais, 2009. http://urlib.net/sid.inpe.br/mtc-m18@80/2009/04.27.18.34.

Full text

Abstract:

O protótipo do Arranjo Decimétrico Brasileiro - BDA, é um arranjo unidimensional Leste-Oeste de 5 antenas de 4 m de diâmetro, com linhas de base de 18 a 216 m, operando na faixa de freqüências 1,2 - 1,7 GHz, com resolução temporal de ~105 ms e tem produzido desde o inicio das operações e de forma regular, franjas de visibilidade em seus 10 pares de correlação. Nesta dissertação foram estudadas, mediante simulações de mapas unidimensionais, as capacidades máximas em resolução espacial e resposta dinâmica do arranjo. Também foram revisados os procedimentos de calibração de amplitude e calibração

APA, Harvard, Vancouver, ISO, and other styles

20

MORORO, JANIO da S. "Estudo de marcação do anticorpo monoclonal anti-PBP2a com sup(99m)Tc." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10164.

Full text

Abstract:

Made available in DSpace on 2014-10-09T12:35:29Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:36Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

APA, Harvard, Vancouver, ISO, and other styles

21

Tunga, Krishna Rajaram. "Experimental and Theoretical Assessment of PBGA Reliability in Conjunction with Field-Use Conditions." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5266.

Full text

Abstract:

With the dramatic advances that have taken place in microelectronics over the past three decades, ball-grid array (BGA) packages are increasingly being used in microsystems applications. BGA packages with area-array configuration have several advantages: smaller footprint, faster signal transmission, testability, reworkability, handling easiness, etc. Although ceramic ball grid array (CBGA) packages have been used extensively in the microsystems industry, the use of plastic ball grid array (PBGA) packages is relatively new, especially for automotive and aerospace applications where harsh the

APA, Harvard, Vancouver, ISO, and other styles

22

Rutschmann, Jens [Verfasser]. "PBP2a als Resistenzdeterminante in Labormutanten und klinischen Isolaten von Streptococcus pneumoniae / Jens Rutschmann." Kaiserslautern : Universitätsbibliothek Kaiserslautern, 2011. http://d-nb.info/1011277328/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Choksi, Nidhi Rajan. "Characterizing Interaction Between PASK and PBP1/ ATXN2 to Regulate Cell Growth and Proliferation." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6527.

Full text

Abstract:

Pbp1 is a component of glucose deprivation induced stress granules and is involved in P-body-dependent granule assembly. We have recently shown that Pbp1 plays an important role in the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (Snf1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1), to regulate glucose allocation during nutrient depletion. This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), w

APA, Harvard, Vancouver, ISO, and other styles

24

Ngeacharernkul, Pratak. "Particle size distribution (PSD) equivalency using novel statistical comparators and PBPK input models." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5973.

Full text

Abstract:

For disperse system drug formulations, meaningful particle size distribution (PSD) comparators are essential in determining pharmaceutical equivalency and predicting biopharmaceutical equivalence in terms of the effect of particle size on the rate and extent of drug input. In formulation development and licensure, particle size characterization has been applied to establish relationships for bioequivalence of generic pharmaceutical drug products. The current approaches recommended by the US-FDA using median and span are not adequate to predict drug product performances or account for multi-mod

APA, Harvard, Vancouver, ISO, and other styles

25

Gerard, Cécile. "Apport des modèles PBPK dans l'optimisation thérapeutique des inhibiteurs des calcineurines en transplantation." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10265/document.

Full text

Abstract:

En transplantation d'organes solides ou en greffe de moelle osseuse, la ciclosporine et letacrolimus ont prouvé leur efficacité. Ils sont cependant de maniement délicat du fait d'unintervalle thérapeutique étroit et d'une grande variabilité pharmacocinétique inter et intraindividuelle.Un suivi thérapeutique et une adaptation des posologies de ces médicaments sontnécessaires pour diminuer le risque de rejet et limiter leur toxicité.Un modèle PBPK est construit à partir de considérations anatomiques, physiologiques etbiochimiques. Il permet d'apporter des informations sur les cinétiques tissulai

APA, Harvard, Vancouver, ISO, and other styles

26

Codaccioni, Marc. "Évaluation de l’exposition fœtale aux substances chimiques grâce à la modélisation pharmacocinétique basée sur la physiologie (PBPK) et son application aux données d’imprégnation des populations." Thesis, Paris, Institut agronomique, vétérinaire et forestier de France, 2020. http://www.theses.fr/2020IAVF0019.

Full text

Abstract:

Des études de biosurveillance ont montré l’exposition des femmes enceintes à des substances de synthèse. Parallèlement, plusieurs études épidémiologiques ont mis en évidence des associations entre des concentrations mesurées dans le sang des femmes enceintes ou dans le sang de cordon et des effets néfastes sur le nouveau-né comme sur sa santé plus tard dans la vie. Néanmoins, ce type de mesures n’offre pas la certitude d’être représentatif des expositions intra-utérines tout au long de la grossesse, et il n’est pas envisageable de mesurer longitudinalement les concentrations fœtales pour des r

APA, Harvard, Vancouver, ISO, and other styles

27

Wu, Tao. "Production de phi et omega dans les collisions PbPb a 158 GeV par nucléon." Phd thesis, Université Paris Sud - Paris XI, 2003. http://tel.archives-ouvertes.fr/tel-00004516.

Full text

Abstract:

Dans les collisions les plus centrales d'ions lourds aux énergies accessibles au SPS du CERN les conditions de densité et d'énergie pourraient conduire à une transition vers un nouvel état de la matière, le plasma de quarks et de gluons. L'effet d'écran sur le J/Psi, où l'augmentation de la production de particules étranges comme le phi pourraient en être des traces caractéristiques. Cette thèse traite principalement de la production de mésons phi mesurés grace à la mesure des paires de muons par la collaboration NA50 au cours de l'année 2000. Plusieurs améliorations dont un nouveau déclenchem

APA, Harvard, Vancouver, ISO, and other styles

28

McGinn, Christopher Francis. "Mapping the redistribution of jet energy in PbPb collisions at the LHC with CMS." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/127721.

Full text

Abstract:

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2019<br>Cataloged from the official PDF of thesis.<br>Includes bibliographical references (pages 195-202).<br>Quenched jets produced in heavy ion collisions at the LHC and reconstructed with the CMS detector are studied to understand the nature of interactions between hardscattered partons and the simultaneously produced hot and dense medium, the Quark- Gluon Plasma (QGP). Jets are objects with color charge evolving through many energy scales, so are an excellent tool for scattering experiment in QGP, with potential

APA, Harvard, Vancouver, ISO, and other styles

29

Cabello, Hernández Pablo Jesús. "Single nanoparticle devices: Trapping and characterizaton." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/150605.

Full text

Abstract:

Magíster en Ciencias, Mención Física<br>La fabricación y posicionamiento de nanopartículas de tamaño y composición ajustable resulta interesante debido a las propiedades que surgen producto del confinamiento en bajas dimensiones. Para acceder a ellas es necesario reemplazar los dispositivos electrónicos macroscópicos típicos por equivalentes nanométricos. En este campo, uno de los mayores retos es elaborar un esquema de medición que permita estudiar el transporte de cargas a través de una nanopartícula individual. Con tal de contactar las nanopartículas a los electrodos en este nuevo esquema,

APA, Harvard, Vancouver, ISO, and other styles

30

Foulquier, Elodie. "Du métabolisme carboné à la morphogenèse : Rôle interprété par YvcK, protéine de Bacillus subtilis." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22077.

Full text

Abstract:

La protéine de fonction inconnue, YvcK, est vitale chez Staphylococcus aureus mais non essentielle chez les bactéries modèles Bacillus subtilis ou Escherichia coli. Chez B. subtilis, les bactéries délétées du gène yvcK, sont sérieusement affectées dans leur croissance et leur morphologie dans des conditions de croissance gluconéogéniques. Les défauts observés peuvent être compensés par l’ajout de fortes concentrations de magnésium ou par l’inactivation de gènes impliqués dans le métabolisme. Ceci suggère que, les mutants yvcK présentent des altérations au niveau de la paroi bactérienne qui son

APA, Harvard, Vancouver, ISO, and other styles

31

Personne, Stéphane. "Développement d'un modèle toxicocinétique basé sur la physiologie pour la perméthrine et ses métabolites chez la rate gestante." Thesis, Amiens, 2019. http://www.theses.fr/2019AMIE0004.

Full text

Abstract:

Les études de biosurveillance ont montré une exposition plus élevée de la population française, y compris les femmes enceintes, aux pyréthrinoïdes par rapport à d'autres pays. Les pyréthrinoïdes sont des composés neurotoxiques qui agissent sur leurs organismes cibles en interférant sur la transmission du signal nerveux. Ces composés passent la barrière placentaire exposant le fœtus durant la période sensible du développement. Au sein de cette famille d'insecticides, la perméthrine (mélange des isomères cis et trans) est le composé le plus utilisé en milieu domestique. L'objectif de ce travail

APA, Harvard, Vancouver, ISO, and other styles

32

Tsamandouras, Nikolaos. "Development and applications of physiologically-based pharmacokinetic models for population data analyses." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/development-and-applications-of-physiologicallybased-pharmacokinetic-models-for-population-data-analyses(5793d86f-75e4-4ed9-89ec-b93e9bc6b2e6).html.

Full text

Abstract:

Physiologically-based pharmacokinetic (PBPK) modelling is traditionally employed to predict drug concentration-time profiles in plasma and tissues using information from physiology/biology, in vitro experiments and in silico predictions. Model-based analysis of population pharmacokinetic (PK) data is rarely performed in such a mechanistic framework, as empirical compartmental models are mainly utilised for this purpose. However, the combination of traditional PBPK methodologies with parameter estimation techniques and non-linear mixed effects modelling is an approach with progressively increas

APA, Harvard, Vancouver, ISO, and other styles

33

Djeghader, Ahmed. "Etude structurale et fonctionnelle des phosphates-binding proteins : Illustration avec les protéines ding et ding-like et leur implication dans l'infection /inhibition du Vih." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4073.

Full text

Abstract:

L’acquisition du phosphate du milieu extracellulaire est un processus biologique primordial pour toute les cellules vivantes. Durant ce travail nous nous sommes intéressé à deux famille de phosphate-binding proteins, les protéines DING et DING-like. Les protéines DING sont des protéines ubiquitaires nommées ainsi en raison de leur extrémité N-terminal très conservée DINGGG-. Bien que largement représentées chez les bactéries, ces protéines ont été identifiées initialement chez l’homme en vertu de leurs propriétés biologiques ou leur implication dans les maladies, y compris dans l’inhibition du

APA, Harvard, Vancouver, ISO, and other styles

34

Lu, Daoqiang. "Synthesis and characterization of a star-like poly(p-Benzamide) (PBA)." Thesis, Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/8604.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Krauß, Markus Verfasser], Andreas [Akademischer Betreuer] Schuppert, and Alexander [Akademischer Betreuer] [Mitsos. "Bayesian population PBPK approach for support of drug development / Markus Krauß ; Andreas Schuppert, Alexander Mitsos." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1129875962/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Singh, Aditi [Verfasser], and Christine [Akademischer Betreuer] Clayton. "Functional characterization of MKT1 and PBP1 proteins in Trypanosoma brucei / Aditi Singh ; Betreuer: Christine Clayton." Heidelberg : University of Heidelberg press, 2013. http://d-nb.info/1177382628/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Querino, Gislaine Aparecida [UNESP]. "Produção de anticorpos monoclonal murino dirigido contra a PBP2a do S. aureus resistente a meticilina." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108579.

Full text

Abstract:

Made available in DSpace on 2014-08-13T14:50:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-26Bitstream added on 2014-08-13T18:00:42Z : No. of bitstreams: 1 000755552_20150226.pdf: 184124 bytes, checksum: bb2e201b69490f217c49869c796c4d73 (MD5) Bitstreams deleted on 2015-02-27T13:20:32Z: 000755552_20150226.pdf,Bitstream added on 2015-02-27T13:21:09Z : No. of bitstreams: 1 000755552.pdf: 1392942 bytes, checksum: 12832e3bab25a912a8be2d25c558be8a (MD5)<br>S. aureus é, sem duvida, o patógeno humano mais importante entre os estafilococos. O surgimento e a disseminação progressiva da

APA, Harvard, Vancouver, ISO, and other styles

38

Querino, Gislaine Aparecida. "Produção de anticorpos monoclonal murino dirigido contra a PBP2a do S. aureus resistente a meticilina /." Botucatu, 2013. http://hdl.handle.net/11449/108579.

Full text

Abstract:

Orientador: Elenice Deffune<br>Banca: Maria de Lourdes Ribeiro da Cunha<br>Banca: Fábio Bernardi Dalpino<br>Resumo: S. aureus é, sem duvida, o patógeno humano mais importante entre os estafilococos. O surgimento e a disseminação progressiva da resistência a meticilina tiveram grande impacto na terapia das infecções estafilocócicas. O mecanismo de resistência a meticilina desenvolvido por S. aureus está relacionado com a alteração das proteínas ligadoras de penicilinas, as PBPs. Os Staphylococcus. aureus produzem 5 tipos de PBPs: 1,2,3,3', e 4. As cepas de S. aureus resistentes a meticilina pro

APA, Harvard, Vancouver, ISO, and other styles

39

Müller, Rodrigo. "Pesquisa de anticorpos anti-PBP2a em pacientes colonizados por Staphylococcus Aureus resistente à meticilina (MRSA)." Instituto de Tecnologia em Imunobiológicos, 2009. https://www.arca.fiocruz.br/handle/icict/5899.

Full text

Abstract:

Submitted by Priscila Nascimento (pnascimento@icict.fiocruz.br) on 2012-11-28T19:21:24Z No. of bitstreams: 1 rodrigo-muller.pdf: 1238864 bytes, checksum: 6c267fda3ccb992508b5424e77147783 (MD5)<br>Made available in DSpace on 2012-11-28T19:21:24Z (GMT). No. of bitstreams: 1 rodrigo-muller.pdf: 1238864 bytes, checksum: 6c267fda3ccb992508b5424e77147783 (MD5) Previous issue date: 2009<br>Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.<br>As infecções causadas por Staphyl

APA, Harvard, Vancouver, ISO, and other styles

40

Tseng, Pin Wen, and 曾品文. "Investigation of the Role of PBP1a, PBP1b and PBP3 on Antibacterial Mechanism of Sulbactam Against Acinetobacter baumannii ATCC 19606." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/37996767316260981250.

Full text

Abstract:

碩士<br>國立清華大學<br>分子醫學研究所<br>104<br>Over the past several decades, the overuse of antibiotics leads to the development of multidrug resistance in pathogens. Many bacteria can resist beta-lactam antibiotics by disrupting the beta-lactam ring of the drugs with -lactamase. To counter the effects of -lactamase, scientists have developed -lactamase inhibitors which protect beta-lactam antibiotic from degradation by irreversible binding with -lactamase. Beta-lactamase inhibitors do not exhibit strong antibacterial activity if given alone. Interestingly, it was noted recently that sulbactam, a 

APA, Harvard, Vancouver, ISO, and other styles

41

Rakhimov, Yestay. "Matematika a implementace PBPK modelů." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388711.

Full text

Abstract:

Charles University Faculty of Pharmacy in Hradec Kr'alov'e Department of Biophysics and Physical Chemistry Candidate: Yestay Rakhimov Supervisor: doc. Erik Jurjen Duintjer Tebbens, Ph.D. Title of diploma thesis: Mathematics and implementations of physiologically based phar- macokinetic modeling The thesis addresses some basic aspects of pharmacokinetic modeling, which is used to describe pharmacokinetic processes. Understanding these processes is important for example to determine optimal concentrations of drugs dosing. The thesis focuses on mathematical proofs of a number of pharmacokinetic e

APA, Harvard, Vancouver, ISO, and other styles

42

Stöckl, Stefanie. "Modellierung PBPK-relevanter Verteilungskoeffizienten organischer Stoffe." Doctoral thesis, 2013. https://tubaf.qucosa.de/id/qucosa%3A22900.

Full text

Abstract:

Drei Verteilungskoeffizienten, die für physiologie-basierte Pharmakokinetik (PBPK)-Modelle relevant sind, wurden mit verschiedenen Ansätzen modelliert. Für den Blut/Luft-Verteilungskoeffizienten wurde ein auf linearen Solvatations-Energie-Beziehungen (LSER) beruhendes Literaturmodell angewendet und diskutiert. Mit einer schematischen Aufteilung des Blutkompartiments in Wasser und einen organischen Teil wurde der Blut/Luft-Verteilungskoeffizient mit einer linearen Regression von anderen Verteilungskoeffizienten vorhergesagt. Zusätzlich wurde ein Fragmentmodell entwickelt. Der Fett/Luft-Verteilu

APA, Harvard, Vancouver, ISO, and other styles

43

Wang, Yu, and 王瑀. "Characterization of PBP2 in Stenotrophomonas maltophilia." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/18198793524053021214.

Full text

Abstract:

碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>104<br>Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity toward β-lactam antibiotic, and involved in the final stages of the synthesis of peptidoglycan, a major component of bacterial cell walls. There are seven annotated PBP genes in the S. maltophilia genome, including five genes encoding high-molecular-weight PBPs (mrcA, mrcB, pbpC, mrdA, and ftsI) and two gene encoding low-molecular-weight PBPs (dacB and dacC). This study aimed to investigate the linkage of mrdA inactivation to β-lactamase expression, and β-la

APA, Harvard, Vancouver, ISO, and other styles

44

Chung, Jen-Shiou, and 鍾禎修. "Life Cycle Assessment of PBGA Substrates." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/16644870267962710866.

Full text

Abstract:

碩士<br>國立交通大學<br>工學院碩士在職專班產業安全與防災學程<br>93<br>PBGA substrates are the key material of semiconductor chips during packaging process. They are the bridge connecting external circuits of the IC chips. Because the PBGA packaging method is a break-through over the original Peripheral Packaging technique, it enables high speed chip function. Besides, It is thinner than the Peripheral Packaging frame, which meets the lighter, thinner, shorter, smaller and good heat dissipation demand of electronic products. There are lots of different materials and chemicals used in the PBGA process. This study invest

APA, Harvard, Vancouver, ISO, and other styles

45

Wang, Cheng Da, and 王晟達. "Preparation and Characterization of PBSA/HNT Nanocomposites." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/30498377846309517198.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Jen-HuiChao and 趙仁輝. "Parametric Anaysis of FC-PBGA Thermal Performance." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/a3pgpm.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Balek, Petr. "Studium pp a PbPb srážek na LHC." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-297446.

Full text

Abstract:

In the present work we study the identification of the particle using deposited charge per unit length in the Pixel detector (part of the ATLAS detector) wich can offer an almost analogous read-out of the deposited charge. First, we parametrically describe the dependences of the deposited charge to reduce the volume of the data used in further analysis. Then we use these parameters as an input for particle identification. We elaborate the method of the identification that allows us to say in most of the cases whether the particle passing through the detector was pion, kaon, or proton. This met

APA, Harvard, Vancouver, ISO, and other styles

48

Pereira, Ana Raquel Ramos 1988. "The recU-pbp2 operon in Staphilococcus aureus." Master's thesis, 2011. http://hdl.handle.net/10451/6233.

Full text

Abstract:

Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2011<br>World wide spread of multidrug resistant Staphylococcus aureus pathogen and the ability to infect healthy individuals in the community calls for development of new chemotherapies against this pathogen, as well for deeper knowledge of its antibiotic resistance mechanisms. PBP2 is a protein that catalyzes the last stages of cell wall synthesis at the bacterial septum and is involved in β-lactam resistance. The pbp2 gene is encoded within an operon where it is transcribed either alone or to

APA, Harvard, Vancouver, ISO, and other styles

49

Huang, Zhi-Jia, and 黃植珈. "The Structure and Rheology of Laponite/PBMA nanocomposite." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/19181749182060694707.

Full text

Abstract:

碩士<br>東海大學<br>化學工程與材料工程學系<br>98<br>We use monomer solution intercalation method to produce silicate ( Laponite )/Butyl methacrylate (PBMA) nano composites of different compositions by in situ polymerization and investigated the composite structure, thermal properties and rheological properties at various temperatures and shear rates. X ray diffraction or XRD was applied to observe its structure; a rheometer, RDAII, was used to analyze the steady-state and dynamic rheological properties of composites, and finally Transmission Electro-Microscopy, or TEM was used to capture the image to assist th

APA, Harvard, Vancouver, ISO, and other styles

50

Hsieh, Yu Chi, and 謝毓琦. "Fabrication and Properties of PBSA/Kenaf Green Composites." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/39885481210761770143.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!