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Relevant bibliographies by topics / PBPK/PD

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Academic literature on the topic 'PBPK/PD'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "PBPK/PD"

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Mi, Kun, Shanju Pu, Yixuan Hou, et al. "Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model." International Journal of Molecular Sciences 23, no. 7 (2022): 3722. http://dx.doi.org/10.3390/ijms23073722.

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Model informed drug development is a valuable tool for drug development and clinical application due to its ability to integrate variability and uncertainty of data. This study aimed to determine an optimal dosage of ceftiofur against P. multocida by ex vivo pharmacokinetic/pharmacodynamic (PK/PD) model and validate the dosage regimens by Physiological based Pharmacokinetic-Pharmacodynamic (PBPK/PD) model. The pharmacokinetic profiles of ceftiofur both in plasma and bronchoalveolar lavage fluid (BALF) are determined. PD performance of ceftiofur against P. multocida was investigated. By establi

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Tanaka, Ryota, Kei Irie, and Tomoyuki Mizuno. "Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing." Antibiotics 14, no. 6 (2025): 541. https://doi.org/10.3390/antibiotics14060541.

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The appropriate use of antibiotics is crucial and involves selecting an optimal dosing regimen based on pharmacokinetic (PK) and pharmacodynamic (PD) indicators. Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool that integrates drugs’ physicochemical properties with anatomical and physiological data to predict PK behavior. In pediatric populations, PBPK modeling accounts for developmental changes in organ function, making it particularly useful for optimizing antibiotic dosing across different age groups, from neonates to adolescents. In recent decades, PBPK modeling has

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Witkowski, Jakub, Sebastian Polak, Zbigniew Rogulski, and Dariusz Pawelec. "In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II." International Journal of Molecular Sciences 23, no. 19 (2022): 11939. http://dx.doi.org/10.3390/ijms231911939.

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The development of in vitro/in vivo translational methods for synergistically acting drug combinations is needed to identify the most effective therapeutic strategies. We performed PBPK/PD modelling for siremadlin, trametinib, and their combination at various dose levels and dosing schedules in an A375 xenografted mouse model (melanoma cells). In this study, we built models based on in vitro ADME and in vivo PK/PD data determined from the literature or estimated by the Simcyp Animal simulator (V21). The developed PBPK/PD models allowed us to account for the interactions between siremadlin and

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Jeong, Hyeon-Cheol, Min-Gul Kim, Zhuodu Wei, et al. "Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations." Pharmaceutics 14, no. 6 (2022): 1298. http://dx.doi.org/10.3390/pharmaceutics14061298.

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A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under various scenarios. The PBPK model for tegoprazan and M1 was developed and predicted using the SimCYP® simulator and verified using clinical study data obtained after a single administration of tegoprazan. The established PBPK/PD model was used to predict PK profiles after repeated administrations of tegoprazan, postprandial PK profiles, and intragastric pH changes. The predicted tegoprazan and M1 concentration–time profiles fit the

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Witkowski, Jakub, Sebastian Polak, Dariusz Pawelec, and Zbigniew Rogulski. "In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III." International Journal of Molecular Sciences 24, no. 3 (2023): 2239. http://dx.doi.org/10.3390/ijms24032239.

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The development of in vitro/in vivo translational methods and a clinical trial framework for synergistically acting drug combinations are needed to identify optimal therapeutic conditions with the most effective therapeutic strategies. We performed physiologically based pharmacokinetic–pharmacodynamic (PBPK/PD) modelling and virtual clinical trial simulations for siremadlin, trametinib, and their combination in a virtual representation of melanoma patients. In this study, we built PBPK/PD models based on data from in vitro absorption, distribution, metabolism, and excretion (ADME), and in vivo

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Kuepfer, L., C. Niederalt, T. Wendl, et al. "Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model." CPT: Pharmacometrics & Systems Pharmacology 5, no. 10 (2016): 516–31. http://dx.doi.org/10.1002/psp4.12134.

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RP, Sharma, Schuhmacher M, and Kumar V. "Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology." Toxicol Lett 280 (October 5, 2017): 79–91. https://doi.org/10.1016/j.toxlet.2017.08.003.

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Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field of toxicology via its coupling to the Physiological based Pharmacokinetics and Pharmacodynamics (PBPK/PD) model. This expansion framework of integrated PBPK/PD coupled mechanistic system pathway model can be called as system toxicology that describes the kinetics of both - the chemicals and - biomolecules, help us to understand the dynamic and s

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Loisios-Konstantinidis, Ioannis, Rodrigo Cristofoletti, Masoud Jamei, David Turner, and Jennifer Dressman. "Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen." Pharmaceutics 12, no. 11 (2020): 1049. http://dx.doi.org/10.3390/pharmaceutics12111049.

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Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharmacodynamics of drug substances. In this study, flurbiprofen, a potent non-steroid anti-inflammatory drug, was chosen as a model drug. Flurbiprofen has absolute bioavailability of ~95% and linear pharmacokinetics in the dose range of 50–300 mg. Its absorption is considered variable and complex, often associated with double peak phenomena, and its pha

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Luecke, Richard H., Bruce A. Pearce, Walter D. Wosilait, Daniel R. Doerge, William Slikker, and John F. Young. "Windows based general PBPK/PD modeling software." Computers in Biology and Medicine 38, no. 9 (2008): 962–78. http://dx.doi.org/10.1016/j.compbiomed.2008.06.001.

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Qian, Lixuan, and Zhu Zhou. "Quantifying Heart Rate Changes After Delta-9-Tetrahydrocannabinol Administration Using a PBPK-PD Model in Healthy Adults." Pharmaceutics 17, no. 2 (2025): 237. https://doi.org/10.3390/pharmaceutics17020237.

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Background: As cannabis becomes legal in several U.S. states, the risk of THC-induced tachycardia increases. This study aimed to develop and verify a physiologically based pharmacokinetic–pharmacodynamic (PBPK-PD) model to assess the impact of THC and its active metabolite, 11-hydroxy-THC (11-OH-THC), on the heart rate of healthy adults. Methods: A PBPK-PD model for intravenous (IV) 11-OH-THC administration was first developed. Secondly, a PBPK-PD model for IV THC, combined with the metabolized 11-OH-THC, was established, verified, and validated. Direct PD models driven by the plasma, brain, a

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Dissertations / Theses on the topic "PBPK/PD"

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Merrill, Elaine Alice. "A Mechanism-Based Model to Describe GABAA Receptor Trafficking and Benzodiazepine Pharmacoresistance during Status Epilepticus." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1347458024.

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Pierrillas, Philippe. "Optimisation du développement clinique de nouveaux anticancéreux par modélisation de données pharmacocinétiques et pharmacodynamiques précliniques." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1047.

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L’amélioration du développement du médicament est un véritable défi et ceci encore plus dans le domaine de l’oncologie dans lequel le besoin d’avoir de nouvelles alternatives thérapeutiques est primordial. De plus, on note que le taux d’approbation des nouveaux anticancéreux après leur entrée en phase 1 fait partie des plus bas taux de toutes les aires thérapeutiques. De ce fait, ce processus doit être amélioré et l’utilisation de nouvelles approches faisant le lien entre développement préclinique et clinique par anticipation des propriétés pharmacocinétiques et d’efficacité pourrait être une

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Bouchene, Salim. "Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280208.

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Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. Colistin is used as salvage therapy against multidrug resistant Gram-negative infections. In this work, a whole-body physiolog

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(9086249), Chandrali S. Bhattacharya. "MEASUREMENT OF STEREOSELECTIVE BUPROPION DISPOSITION IN RAT BRAIN TO SUPPORT TRANSLATIONAL PBPK/PD MODEL DEVELOPMENT AND APPLICATION." Thesis, 2020.

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<div><b>Background:</b> Bupropion, an atypical antidepressant and smoking cessation aid, is associated with wide inter-subject variability in its efficacy and safety. Variability in response to bupropion therapy is thought to be driven by variability in metabolism. Bupropion undergoes complex phase 1 and 2 stereoselective metabolism. Though bupropion`s pharmacology is not fully understood, much of it is thought to be due to its metabolites, specially, S, S-hydroxybupropion. In vitro studies (functional assays measuring IC50 at dopamine transporter-DAT, norepinephrine transporter-NET, various

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Books on the topic "PBPK/PD"

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Knaak, James B., Charles Timchalk, and Rogelio Tornero-Velez, eds. Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1099.

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Knaak, James B., Charles Timchalk, and Rogelio Tornero-Velez. Parameters for pesticide QSAR and PBPK/PD models for human risk assessment. Edited by American Chemical Society and American Chemical Society. Division of Agrochemicals. American Chemical Society, 2012.

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Book chapters on the topic "PBPK/PD"

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Goldsmith, M. R., J. C. Johnson, D. T. Chang, R. Tornero-Velez, J. B. Knaak, and Curtis C. Dary. "Parameters for Pesticide QSAR and PBPK/PD Models To Inform Human Risk Assessments." In ACS Symposium Series. American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1099.ch001.

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Knaak, James B., Curt C. Dary, Miles S. Okino, et al. "Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment." In Reviews of Environmental Contamination and Toxicology. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-73163-6_3.

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Knaak, James B., Curtis C. Dary, Xiaofei Zhang, et al. "Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment." In Reviews of Environmental Contamination and Toxicology. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3281-4_1.

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Saha, Gourab. "Computer Simulations in Pharmacokinetics and Pharmacodynamics." In Computer Aided Drug Development. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/x2158555.

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Computer simulations have revolutionized the understanding and prediction of pharmacokinetic (PK) and pharmacodynamic (PD) processes in drug development. Advanced computational models integrate physiological parameters, drug properties, and patient characteristics to predict drug behavior in the body. These simulations employ complex mathematical algorithms to analyze drug absorption, distribution, metabolism, and excretion patterns while considering population variability. Modern PK/PD modeling incorporates artificial intelligence and machine learning to enhance prediction accuracy and optimi

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Conference papers on the topic "PBPK/PD"

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Hang Chen, Xuan Wang, and Xin-zhong Chen. "A Novel PBPK/PD Model with Automatic Nervous System in Anesthesia." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616343.

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Timchalk, C., A. Kousba, and T. Poet. "49. A Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model for Chlorpyrifos Utilizing Neonatal Rats as Surrogates for Children." In AIHce 2002. AIHA, 2002. http://dx.doi.org/10.3320/1.2766399.

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Dey, Agnish, Hideaki Kagehara, Petar Pop-Damkov, et al. "245 Development and application of physiologically based pharmacokinetic – pharmacodynamic (PBPK-PD) model for dose optimization of TAK-102: GPC3 targeted CAR-T armored with IL-7 and CCL-19." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0245.

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Reports on the topic "PBPK/PD"

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Mattie, David R., Teresa R. Sterner, Elaine A. Merrill, and Rebecca A. Clewell. Using Human Life Stage PBPK/PD Model Predictions of Perchlorate-Induced Iodide Inhibition to Inform Risk Assessment in Sensitive Populations. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada458548.

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