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Journal articles on the topic 'PBR28'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Owen, David R., Owain W. Howell, Sac-Pham Tang, et al. "Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 30, no. 9 (2010): 1608–18. http://dx.doi.org/10.1038/jcbfm.2010.63.

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[11C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [11C]PK11195, another TSPO radioligand. We measured the specific binding signals with [3H]PK11195 and [3H]PBR28 in brain tissue from 22 donors. Overall, 23% of the samples did not generate a visually detectable specific autoradiographic signal with [3H]PBR28, although all samples showed [3H]PK11195 binding. There was a marked reduction in the affinity of [3H]PBR28 for TSPO in samples with no visible

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Datta, Gourab, Ines R. Violante, Gregory Scott, et al. "Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis." Multiple Sclerosis Journal 23, no. 11 (2016): 1469–78. http://dx.doi.org/10.1177/1352458516681504.

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Background: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. Objective: To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. Methods: A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability

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Herranz, Elena, Céline Louapre, Constantina Andrada Treaba, et al. "Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging." Multiple Sclerosis Journal 26, no. 12 (2019): 1497–509. http://dx.doi.org/10.1177/1352458519867320.

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Background: Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Objective: Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing–remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Methods: Mean 11C-PBR28 uptake was measured in focal cortical lesions, cort

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Owen, David R., Astrid J. Yeo, Roger N. Gunn, et al. "An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28." Journal of Cerebral Blood Flow & Metabolism 32, no. 1 (2011): 1–5. http://dx.doi.org/10.1038/jcbfm.2011.147.

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[11C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the

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Kreisl, William C., Kimberly J. Jenko, Christina S. Hines, et al. "A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 33, no. 1 (2012): 53–58. http://dx.doi.org/10.1038/jcbfm.2012.131.

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Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous (HL). We tested if in vitro binding to leukocytes distinguished TSPO genotypes and if genotype could affect clinical studies using the TSPO radioligand [11C]PBR28. In vitro binding to leukocytes and [11C]PBR28 brain imaging were performed in 27 human subjects with known TSPO genotype. Specific [3H]P

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Toppala, Sini, Laura L. Ekblad, Jouni Tuisku та ін. "Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia". Neurology 96, № 12 (2021): e1608-e1619. http://dx.doi.org/10.1212/wnl.0000000000011612.

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ObjectiveTo examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.MethodsWe examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [11C]PBR28 to assess neuroinflammation and with [11C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [11C]PBR28 and [11C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, r

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Auriemma, Renato, Mattia Sponchioni, Umberto Capasso Palmiero, et al. "Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles." Nanomaterials 11, no. 7 (2021): 1693. http://dx.doi.org/10.3390/nano11071693.

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Reactive microgliosis is a pathological hallmark that accompanies neuronal demise in many neurodegenerative diseases, ranging from acute brain/spinal cord injuries to chronic diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and age-related dementia. One strategy to assess and monitor microgliosis is to use positron emission tomography (PET) by exploiting radioligands selective for the 18 kDa translocator protein (TSPO) which is highly upregulated in the brain in pathological conditions. Several TSPO ligands have been developed and validated, so far. Among these,

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Sandiego, Christine M., Jean-Dominique Gallezot, Brian Pittman, et al. "Imaging robust microglial activation after lipopolysaccharide administration in humans with PET." Proceedings of the National Academy of Sciences 112, no. 40 (2015): 12468–73. http://dx.doi.org/10.1073/pnas.1511003112.

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Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [11C]PBR28, which binds to translocator protein, a molecular marker that is up-regulated by microglial activation. In addition, inflammatory cytokines in serum and sickness beh

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Sari, Hasan, Riccardo Galbusera, Guillaume Bonnier, et al. "Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers." Neurology - Neuroimmunology Neuroinflammation 9, no. 2 (2022): e1144. http://dx.doi.org/10.1212/nxi.0000000000001144.

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Background and ObjectivesThe presence of HIV in the CNS has been related to chronic immune activation and cognitive dysfunction. The aim of this work was to investigate (1) the presence of neuroinflammation in aviremic people with HIV (PWH) on therapy and in nontreated aviremic PWH (elite controllers [ECs]) using a translocator protein 18 kDa radioligand; (2) the relationship between neuroinflammation and cognitive function in aviremic PWH; and (3) the relationship between [11C]-PBR28 signal and quantitative MRI (qMRI) measures of brain tissue integrity such as T1 and T2 relaxation times (rts)

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Femminella, Grazia Daniela, Melanie Dani, Melanie Wood, et al. "Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume." Neurology 92, no. 12 (2019): e1331-e1343. http://dx.doi.org/10.1212/wnl.0000000000007133.

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ObjectiveTo investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI).MethodsIn this study, 55 participants (37 with early stages of MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate gray matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT(volume of distribution) was calculated using arteria

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Walker, Matthew D., Katherine Dinelle, Rick Kornelsen, et al. "[11C]PBR28 PET Imaging is Sensitive to Neuroinflammation in the Aged Rat." Journal of Cerebral Blood Flow & Metabolism 35, no. 8 (2015): 1331–38. http://dx.doi.org/10.1038/jcbfm.2015.54.

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Neuroinflammation in the aging rat brain was investigated using [11C]PBR28 microPET (positron emission tomography) imaging. Normal rats were studied alongside LRRK2 p.G2019S transgenic rats; this mutation increases the risk of Parkinson's disease in humans. Seventy [11C]PBR28 PET scans were acquired. Arterial blood sampling enabled tracer kinetic modeling and estimation of VT. In vitro autoradiography was also performed. PBR28 uptake increased with age, without differences between nontransgenic and transgenic rats. In 12 months of aging (4 to 16 months), standard uptake value (SUV) increased b

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Rizzo, Gaia, Mattia Veronese, Matteo Tonietto, Paolo Zanotti-Fregonara, Federico E. Turkheimer, and Alessandra Bertoldo. "Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data." Journal of Cerebral Blood Flow & Metabolism 34, no. 6 (2014): 1060–69. http://dx.doi.org/10.1038/jcbfm.2014.55.

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The positron emission tomography radioligand [11C]PBR28 targets translocator protein (18 kDa) (TSPO) and is a potential marker of neuroinflammation. [11C]PBR28 binding is commonly quantified using a two-tissue compartment model and an arterial input function. Previous studies with [11C]HRJ-PK11195 demonstrated a slow irreversible binding component to the TSPO proteins localized in the endothelium of brain vessels, such as venous sinuses and arteries. However, the impact of this component on the quantification of [11C]PBR28 data has never been investigated. In this work we propose a novel kinet

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Tran, Thuy T., Jean-Dominique Gallezot, Lucia B. Jilaveanu, et al. "[11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis." Molecular Imaging 19 (January 1, 2020): 153601212096866. http://dx.doi.org/10.1177/1536012120968669.

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Purpose: As stereotactic radiosurgery (SRS) and immunotherapy are increasingly used to treat brain metastases, incidence of radiation necrosis (RN) is consequently rising. Differentiating tumor regrowth (TR) from RN is vital in management but difficult to assess using MRI. We hypothesized that tumor methionine levels would be elevated given increased metabolism and high amino acid uptake, whereas RN would increase inflammation marked by upregulated translocator protein (PBR-TSPO), which can be quantified with specific PET tracers. Procedures: We performed a feasibility study to prospectively e

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Pascual, Belen, Quentin Funk, Paolo Zanotti-Fregonara, et al. "Neuroinflammation is highest in areas of disease progression in semantic dementia." Brain 144, no. 5 (2021): 1565–75. http://dx.doi.org/10.1093/brain/awab057.

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Abstract Despite epidemiological and genetic data linking semantic dementia to inflammation, the topography of neuroinflammation in semantic dementia, also known as the semantic variant of primary progressive aphasia, remains unclear. The pathology starts at the tip of the left temporal lobe where, in addition to cortical atrophy, a strong signal appears with the tau PET tracer 18F-flortaucipir, even though the disease is not typically associated with tau but with TDP-43 protein aggregates. Here, we characterized the topography of inflammation in semantic variant primary progressive aphasia us

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Barletta, Valeria T., Elena Herranz, Costantina A. Treaba, et al. "Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET." Multiple Sclerosis Journal 26, no. 6 (2019): 668–78. http://dx.doi.org/10.1177/1352458519843048.

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Background: Activated microglia, which can be detected in vivo by 11C-PBR28 positron emission tomography (PET), represent a main component of MS pathology in the brain. Their role in the cerebellum is still unexplored, although cerebellar involvement in MS is frequent and accounts for disability progression. Objectives: We aimed at characterizing cerebellar neuroinflammation in MS patients compared to healthy subjects by combining 11C-PBR28 MRI-Positron Emission Tomography (MR-PET) with 7 Tesla (T) MRI and assessing its relationship with brain neuroinflammation and clinical outcome measures. M

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Collste, K., A. Forsberg, A. Varrone, et al. "Test-retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects." European Journal of Nuclear Medecine and Molecular Imaging 43, no. 1 (2015): 173–83. https://doi.org/10.1007/s00259-015-3149-8.

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PURPOSE: The PET radioligand [<sup>11</sup>C]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation. We examined the reproducibility of [<sup>11</sup>C]PBR28 binding in healthy subjects with quantification on a regional and voxel-by-voxel basis. In addition, we performed a preliminary analysis of diurnal changes in TSPO availability. METHODS: Twelve subjects were examined using a high-resolution research tomograph and [<sup>11</sup>C]PBR28, six in the morning and afternoon of the same day, and six in the morning on two separate days. Regional volumes of distributio

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Solingapuram Sai, Kiran Kumar. "Improved Automated Radiosynthesis of [11C]PBR28." Scientia Pharmaceutica 83, no. 3 (2015): 413–27. http://dx.doi.org/10.3797/scipharm.1505-06.

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Marques, Tiago Reis, Mattia Veronese, David R. Owen, Eugenii A. Rabiner, Graham E. Searle, and Oliver D. Howes. "Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study." European Journal of Nuclear Medicine and Molecular Imaging 48, no. 11 (2021): 3530–39. http://dx.doi.org/10.1007/s00259-021-05327-x.

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Abstract Objective The mitochondrial 18-kDa translocator protein (TSPO) is expressed by activated microglia and positron emission tomography enables the measurement of TSPO levels in the brain. Findings in schizophrenia have shown to vary depending on the outcome measure used and this discrepancy in TSPO results could be explained by lower non-displaceable binding (VND) in schizophrenia, which could obscure increases in specific binding. In this study, we have used the TSPO ligand XBD173 to block the TSPO radioligand [11C]-PBR28 and used an occupancy plot to quantify VND in patients with schiz

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Ghosh, Krishna Kanta, Parasuraman Padmanabhan, Chang-Tong Yang, et al. "An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [11C]PBR28 and [18F]flumazenil PET Imaging." International Journal of Molecular Sciences 22, no. 2 (2021): 951. http://dx.doi.org/10.3390/ijms22020951.

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Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET) have made it possible to map certain features of TBI-induced cellular and molecular changes equally in humans and animals. The PET imaging technique is an apt supplement to nanotheranostic-based treatment alternatives that are emerging to tackle TBI. The present study aims to inv

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Rizzo, Gaia, Mattia Veronese, Matteo Tonietto, et al. "Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities." Journal of Cerebral Blood Flow & Metabolism 39, no. 5 (2017): 874–85. http://dx.doi.org/10.1177/0271678x17742004.

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The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main target of positron emission tomography (PET) ligands for neuroinflammation. Previous works showed that accounting for TSPO endothelial binding improves PET quantification for [11C]PBR28, [18F]DPA714 and [11C]-R-PK11195. It is still unclear, however, whether the vascular signal is tracer-dependent. This work aims to explore the relationship between the TSPO vascular and tissue components for PET tracers with varying affinity, also assessing the impact of affinity towards the differentiability amongst kinetic

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Paul, Soumen, Evan Gallagher, Jeih-San Liow, et al. "Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects." Journal of Cerebral Blood Flow & Metabolism 39, no. 6 (2018): 1138–47. http://dx.doi.org/10.1177/0271678x18771250.

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Translocator protein 18 kDa (TSPO) has been widely imaged as a marker of neuroinflammation using several radioligands, including [11C]PBR28. In order to study the effects of age, sex, and obesity on TSPO binding and to determine whether this binding can be accurately assessed using fewer radio high-performance liquid chromatography (radio-HPLC) measurements of arterial blood samples, we created a database of 48 healthy subjects who had undergone [11C]PBR28 scans (23 high-affinity binders (HABs) and 25 mixed-affinity binders (MABs), 20 F/28 M, age: 40.6 ± 16.8 years). After analysis by Logan pl

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Perusina Lanfranca, Mirna, Marina Pasca Di Magliano, Morand Piert, Weiping Zou, and Timothy Frankel. "Use of [11C]PBR28 to localize and quantify tumor associated macrophages in pancreas cancer (TUM6P.1008)." Journal of Immunology 194, no. 1_Supplement (2015): 141.32. http://dx.doi.org/10.4049/jimmunol.194.supp.141.32.

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Abstract Tumor associated macrophages (TAM) are an important part of the immune microenvironment in pancreas cancer (PC) and are associated with poor prognosis. We investigated the use of a novel radiolabeled small molecule ([11C]PBR28), which binds to the macrophage translocator protein (TSPO), to track TAMs in-vivo. A murine PC line was generated from a KRAS/P53 mutant transgenic mouse. Immunoblotting confirmed lack of endogenous TSPO expression. After subcutaneous implantation, mice were administered [11C]PBR28. After micro-PET imaging, organs and tumors were harvested for autoradiography.

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Veronese, Mattia, Marcello Tuosto, Tiago Reis Marques, et al. "Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function." Molecular Imaging and Biology 23, no. 4 (2021): 560–71. http://dx.doi.org/10.1007/s11307-020-01575-9.

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Abstract Purpose The aim of this study was to investigate the use of spectral analysis (SA) for voxel-wise analysis of TSPO PET imaging studies. TSPO PET quantification is methodologically complicated by the heterogeneity of TSPO expression and its cell-dependent modulation during neuroinflammatory response. Compartmental models to account for this complexity exist, but they are unreliable at the high noise typical of voxel data. On the contrary, SA is noise-robust for parametric mapping and provides useful information about tracer kinetics with a free compartmental structure. Procedures SA im

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Tóth, Miklós, Janine Doorduin, Jenny Häggkvist, et al. "Positron Emission Tomography studies with [11C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation." PLoS One 10, no. 5 (2015): e0125917. https://doi.org/10.1371/journal.pone.0125917.

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Molecular imaging of the 18 kD Translocator protein (TSPO) with positron emission tomography (PET) is of great value for studying neuroinflammation in rodents longitudinally. Quantification of the TSPO in rodents is, however, quite challenging. There is no suitable reference region and the use of plasma-derived input is not an option for longitudinal studies. The aim of this study was therefore to evaluate the use of the standardized uptake value (SUV) as an outcome measure for TSPO imaging in rodent brain PET studies, using [11C]PBR28. In the first part of the study, healthy male Wistar rats

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Forsberg, Anton, Simon Cervenka, Fagerlund Malin Jonsson, et al. "The immune response of the human brain to abdominal surgery." Annals of Neurology 81, no. 4 (2017): 572–82. https://doi.org/10.1002/ana.24909.

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<strong>Abstract</strong> Objective: Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear in humans. This study examines the short- and long-term impact of abdominal surgery on the human brain immune system by positron emission tomography (PET) in relation to blood immune reactivity, plasma inflammatory biomarkers, and cognitive function. Methods: Eight males undergoing pros

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Zhu, Yehui, Natalie Swanson, Mehrbod Mohammadian, et al. "Abstract 803: Elevated neuroinflammation in women with breast cancer: initial insights from [11C]PBR28 PET/MR imaging." Cancer Research 85, no. 8_Supplement_1 (2025): 803. https://doi.org/10.1158/1538-7445.am2025-803.

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Abstract Introduction: As breast cancer survivorship rises, addressing the long-term side effects of cancer and its treatment is crucial. Chemotherapy has been linked to neuroinflammation, leading to cognitive and neurological impairments. However, other treatments (e.g., surgery, endocrine therapy) or related conditions (e.g., pain, cancer progression) may impact neuroinflammation as well. Methods: This cross-sectional study used Siemens 3T integrated positron emission tomography-magnetic resonance imaging (PET/MRI) with the radioligand [11C]PBR28, which binds to the neuroinflammation marker

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Owen, David R., Qi Guo, Nicola J. Kalk, et al. "Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study." Journal of Cerebral Blood Flow & Metabolism 34, no. 6 (2014): 989–94. http://dx.doi.org/10.1038/jcbfm.2014.46.

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Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential ( BP ND). Here, we used blockade of the TSPO radioligand [11C]PBR28 with the TSPO ligand XBD173, to determine the non-displaceable volume of distribution ( V ND), and hence estimate the BP ND. A total of 26 healthy volunteers, 16 high-affinity binders (HABs) and 10 mixed affinity binders (MABs) underwent a [11C]PBR28 PET s

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Mabrouk, Rostom. "Principal Component Analysis versus Subject’s Residual Profile Analysis for Neuroinflammation Investigation in Parkinson Patients: A PET Brain Imaging Study." Journal of Imaging 8, no. 3 (2022): 56. http://dx.doi.org/10.3390/jimaging8030056.

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Dysfunction of neurons in the central nervous system is the primary pathological feature of Parkinson’s disease (PD). Despite different triggering, emerging evidence indicates that neuroinflammation revealed through microglia activation is critical for PD. Moreover, recent investigations sought a potential relationship between Lrrk2 genetic mutation and microglia activation. In this paper, neuroinflammation in sporadic PD, Lrrk2-PD and unaffected Lrrk2 mutation carriers were investigated. The principal component analysis (PCA) and the subject’s residual profile (SRP) techniques were performed

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Schain, Martin, Francesca Zanderigo, R. Todd Ogden, and William C. Kreisl. "Non-invasive estimation of [11C]PBR28 binding potential." NeuroImage 169 (April 2018): 278–85. http://dx.doi.org/10.1016/j.neuroimage.2017.12.002.

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Moon, Byung Seok, Bom Sahn Kim, Chansoo Park, et al. "[18F]Fluoromethyl-PBR28 as a Potential Radiotracer for TSPO: Preclinical Comparison with [11C]PBR28 in a Rat Model of Neuroinflammation." Bioconjugate Chemistry 25, no. 2 (2014): 442–50. http://dx.doi.org/10.1021/bc400556h.

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Guo, Qi, David R. Owen, Eugenii A. Rabiner, Federico E. Turkheimer, and Roger N. Gunn. "A Graphical Method to Compare the in vivo Binding Potential of PET Radioligands in the Absence of a Reference Region: Application to [11C]PBR28 and [18F]PBR111 for TSPO Imaging." Journal of Cerebral Blood Flow & Metabolism 34, no. 7 (2014): 1162–68. http://dx.doi.org/10.1038/jcbfm.2014.65.

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Positron emission tomography (PET) radioligands for a reversible central nervous system (CNS) demand a high specific to nonspecific signal characterized by the binding potential ( BPND). The quantification of BPND requires the determination of the nondisplaceable binding usually derived from a reference region devoid of the target of interest. However, for many CNS targets, there is no valid reference region available. In such cases, the total volume of distribution ( VT) is often used as the outcome measure, which includes both the specific and nonspecific binding signals. Here we present a g

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Pike, Chelsea K., Minhae Kim, Kristina Schnitzer, et al. "Study protocol for a phase II, double-blind, randomised controlled trial of cannabidiol (CBD) compared with placebo for reduction of brain neuroinflammation in adults with chronic low back pain." BMJ Open 12, no. 9 (2022): e063613. http://dx.doi.org/10.1136/bmjopen-2022-063613.

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IntroductionChronic pain is a debilitating medical problem that is difficult to treat. Neuroinflammatory pathways have emerged as a potential therapeutic target, as preclinical studies have demonstrated that glial cells and neuroglial interactions play a role in the establishment and maintenance of pain. Recently, we used positron emission tomography (PET) to demonstrate increased levels of 18 kDa translocator protein (TSPO) binding, a marker of glial activation, in patients with chronic low back pain (cLBP). Cannabidiol (CBD) is a glial inhibitor in animal models, but studies have not assesse

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Barichello, Tatiana, Vijayasree V. Giridharan, Giselli Scaini, et al. "Trajectory of neuro-inflammation and microglial activation assessed using Translocator protein (18kDa TSPO) and positron emission tomography (PET) imaging in bacterial meningitis." Journal of Immunology 200, no. 1_Supplement (2018): 50.4. http://dx.doi.org/10.4049/jimmunol.200.supp.50.4.

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Abstract Here we present novel data from acute (24 hours) and chronic (10 days) pneumococcal meningitis rat survivors evaluating microglia activation through [11C] PBR28, a tracer targeting the TSPO using PET-imaging. Wistar rats received an injection of Streptococcus pneumoniae or artificial-CSF through the cisterna magna following by ceftriaxone/100 mg/kg/7days. At 24 hours and 10 days the animals were subjected to TSPO-PET-imaging. Following the imaging IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-17, IL-18, IFN-γ, TNF-α, and microglial marker Iba-1 and astrocyte marker GFA

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Zhu, Yehui, Natalie Swanson, Jennifer Murphy, et al. "Abstract LB419: Neuroinflammation and aromatase inhibitor associated musculoskeletal syndrome (AIMSS) in breast cancer: Initial insights from [11C]PBR28 PET/MR imaging." Cancer Research 84, no. 7_Supplement (2024): LB419. http://dx.doi.org/10.1158/1538-7445.am2024-lb419.

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Abstract Introduction: While 5-10 years of aromatase inhibitor (AI) treatment clearly improves survival rates of postmenopausal women with hormone-sensitive breast cancer, up to 85% of AI users report aromatase inhibitor associated musculoskeletal syndrome (AIMSS, including arthralgias, myalgias, and muscle stiffness). The biological mechanisms underlying AIMSS are not well understood, but accumulating preclinical and clinical evidence implicate an important role for neuroinflammation in the development and maintenance of other types of chronic musculoskeletal pain (e.g., low back pain, fibrom

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Veronese, Mattia, Tiago Reis Marques, Peter S. Bloomfield, et al. "Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis." Journal of Cerebral Blood Flow & Metabolism 38, no. 7 (2017): 1227–42. http://dx.doi.org/10.1177/0271678x17712388.

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The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central nervous system and represents the main target of radiotracers for the in vivo quantification of neuroinflammation with positron emission tomography (PET). TSPO PET is methodologically challenging given the heterogeneous distribution of TSPO in blood and brain. Our previous studies with the TSPO tracers [11C]PBR28 and [11C]PK11195 demonstrated that a model accounting for TSPO binding to the endothelium improves the quantification of PET data. Here, we performed a validation of the kinetic model with the ad

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Real, Caroline C., Janine Doorduin, Paula Kopschina Feltes, et al. "Evaluation of exercise-induced modulation of glial activation and dopaminergic damage in a rat model of Parkinson’s disease using [11C]PBR28 and [18F]FDOPA PET." Journal of Cerebral Blood Flow & Metabolism 39, no. 6 (2017): 989–1004. http://dx.doi.org/10.1177/0271678x17750351.

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Evidence suggests that exercise can modulate neuroinflammation and neuronal damage. We evaluated if such effects of exercise can be detected with positron emission tomography (PET) in a rat model of Parkinson’s disease (PD). Rats were unilaterally injected in the striatum with 6-hydroxydopamine (PD rats) or saline (controls) and either remained sedentary (SED) or were forced to exercise three times per week for 40 min (EX). Motor and cognitive functions were evaluated by the open field, novel object recognition, and cylinder tests. At baseline, day 10 and 30, glial activation and dopamine synt

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Yoder, K. K., K. Nho, S. L. Risacher, S. Kim, L. Shen, and A. J. Saykin. "Influence of TSPO Genotype on 11C-PBR28 Standardized Uptake Values." Journal of Nuclear Medicine 54, no. 8 (2013): 1320–22. http://dx.doi.org/10.2967/jnumed.112.118885.

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Wang, Min, Karmen K. Yoder, Mingzhang Gao, et al. "Fully automated synthesis and initial PET evaluation of [11C]PBR28." Bioorganic & Medicinal Chemistry Letters 19, no. 19 (2009): 5636–39. http://dx.doi.org/10.1016/j.bmcl.2009.08.051.

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Aceves-Serrano, Lucero, Jason L. Neva, Jonathan Munro, et al. "Evaluation of microglia activation related markers following a clinical course of TBS: A non-human primate study." PLOS ONE 19, no. 5 (2024): e0301118. http://dx.doi.org/10.1371/journal.pone.0301118.

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While the applicability and popularity of theta burst stimulation (TBS) paradigms remain, current knowledge of their neurobiological effects is still limited, especially with respect to their impact on glial cells and neuroinflammatory processes. We used a multimodal imaging approach to assess the effects of a clinical course of TBS on markers for microglia activation and tissue injury as an indirect assessment of neuroinflammatory processes. Healthy non-human primates received continuous TBS (cTBS), intermittent TBS (iTBS), or sham stimulation over the motor cortex at 90% of resting motor thr

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Lee, Seok-Yong, Ho Rim Oh, Young-Hwa Kim, et al. "Abstract 5046: Cerenkov luminescence imaging of interscapular brown adipose tissue using TSPO-targeting probe to overcome off-target effect of [18F]FDG." Cancer Research 83, no. 7_Supplement (2023): 5046. http://dx.doi.org/10.1158/1538-7445.am2023-5046.

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Abstract Aim/Introduction: [18F]fluorodeoxyglucose-positron emission tomography ([18F]FDG-PET) has been used as an imaging methods for measuring interscapular brown adipose tissue (iBAT) activity. However, [18F]FDG-PET has limitations for obtaining iBAT-specific images due to off-target effects with high uptake in skeletal muscle, tumors, and inflamed tissue. Uncoupling protein 1 (UCP1), a well-known biomarker for BAT, located in mitochondria also has been suggested as BAT imaging marker. Recently, UCP1 ThermoMouse was established as a reporter mouse for monitoring UCP1 expression. Translocato

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Lois, Cristina, Iván González, David Izquierdo-García, et al. "Neuroinflammation in Huntington’s Disease: New Insights with 11C-PBR28 PET/MRI." ACS Chemical Neuroscience 9, no. 11 (2018): 2563–71. http://dx.doi.org/10.1021/acschemneuro.8b00072.

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Kim, Min-Jeong, Meghan McGwier, Kimberly J. Jenko, et al. "Neuroinflammation in frontotemporal lobar degeneration revealed by 11 C‐PBR28 PET." Annals of Clinical and Translational Neurology 6, no. 7 (2019): 1327–31. http://dx.doi.org/10.1002/acn3.50802.

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Turecki, Lauren, Santhoshi P. Palandira, Hui Liu, et al. "Imaging neuroinflammation in murine endotoxemia: a dual-tracer microPET evaluation." Journal of Immunology 204, no. 1_Supplement (2020): 144.19. http://dx.doi.org/10.4049/jimmunol.204.supp.144.19.

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Abstract Brain dysfunction, including neuroinflammation, metabolic changes, and cognitive impairment has been reported in sepsis and other disorders “traditionally” characterized by peripheral immune and metabolic dysregulation (Annu Rev Immunol, 2018, 36:783–812). In this context, non-invasive evaluation of neuroinflammation is important for strategizing new diagnostic and therapeutic approaches targeting the brain. We utilized Micro Positron Emission Tomography (microPET) with [18F]Fluoro-2-deoxy-2-D-glucose (18FDG) and 11C-Peripheral Benzodiazepine Receptor ([11C]PBR) to evaluate brain meta

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Aertker, Benjamin M., Akshita Kumar, Fanni Cardenas, et al. "PET Imaging of Peripheral Benzodiazepine Receptor Standard Uptake Value Increases After Controlled Cortical Impact, a Rodent Model of Traumatic Brain Injury." ASN Neuro 13 (January 2021): 175909142110141. http://dx.doi.org/10.1177/17590914211014135.

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Traumatic brain injury (TBI) is a chronic, life threatening injury for which few effective interventions are available. Evidence in animal models suggests un-checked immune activation may contribute to the pathophysiology. Changes in regional density of active brain microglia can be quantified in vivo with positron emission topography (PET) with the relatively selective radiotracer, peripheral benzodiazepine receptor 28 (11 C-PBR28). Phenotypic assessment (activated vs resting) can subsequently be assessed (ex vivo) using morphological techniques. To elucidate the mechanistic contribution of i

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Barichello, Tatiana, Vijayasree V. Giridharan, Fabricia Petronilho, Jaqueline S. Generoso, Diogo Dominguini, and Felipe Dal-Pizzol. "PET imaging of TSPO in a rat model of sepsis induced by peritoneal polymicrobial infection." Journal of Immunology 202, no. 1_Supplement (2019): 120.11. http://dx.doi.org/10.4049/jimmunol.202.supp.120.11.

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Abstract Background Sepsis is a life-threatening acute organ dysfunction secondary to infection that affects more than 30 million people worldwide. In the USA, 1.5 million people develop sepsis, and at least 250,000 Americans die from sepsis each year. After hospitalization, patients suffer from long-term impairments in memory, attention, verbal fluency, and executive functioning. The translocator protein (TSPO), marker of activated microglia astrocytes cells, can be measured in vivo using positron emission tomography (PET). Our working hypothesis is that systemic inflammation associated with

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Albrecht, Daniel S., Marc D. Normandin, Sergey Shcherbinin, et al. "Pseudoreference Regions for Glial Imaging with11C-PBR28: Investigation in 2 Clinical Cohorts." Journal of Nuclear Medicine 59, no. 1 (2017): 107–14. http://dx.doi.org/10.2967/jnumed.116.178335.

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Cho, Yong-Hyun, Yong-Seok Lee, Yun-Sang Lee, and Gi Jeong Cheon. "Development of automatic synthesis method for [18F]Fluoromethyl-PBR28 using two synthesizer." Nuclear Medicine and Biology 108-109 (May 2022): S123. http://dx.doi.org/10.1016/s0969-8051(22)00271-2.

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Kreisl, William C., Chul Hyoung Lyoo, Jeih-San Liow, et al. "11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease." Neurobiology of Aging 44 (August 2016): 53–61. http://dx.doi.org/10.1016/j.neurobiolaging.2016.04.011.

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Narayan, Nehal, Christopher Coello, Azeem Saleem, and Peter Taylor. "Utility of [ 11 C]PBR28 PET in the imaging of inflammatory arthritis." Lancet 389 (February 2017): S73. http://dx.doi.org/10.1016/s0140-6736(17)30469-5.

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Fan, Zhen, Melanie Dani, Grazia Daniela Femminella, et al. "[P1-124]: REGIONAL KINETIC MODELLING APPLICATION FOR TSPO PET TRACER [11C]PBR28." Alzheimer's & Dementia 13, no. 7S_Part_5 (2017): P289. http://dx.doi.org/10.1016/j.jalz.2017.06.191.

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