Relevant bibliographies by topics / PC3

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'PC3'

Author: Grafiati
Published: 4 June 2021
Last updated: 23 February 2023

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Journal articles on the topic "PC3"

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Al-Sehemi, Abdullah G., Tarek M. El-Gogary, Karl Peter Wolschann, and Gottfried Koehler. "Structure and Stability of Chemically Modified DNA Bases: Quantum Chemical Calculations on 16 Isomers of Diphosphocytosine." ISRN Physical Chemistry 2013 (February 25, 2013): 1–10. http://dx.doi.org/10.1155/2013/146401.

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We studied for the first time 16 tautomers/rotamers of diphosphocytosine by four computational methods. Some of these tautomers/rotamers are isoenergetic although they have different structures. High-level electron correlation MP2 and MP4(SDQ) ab initio methods and density functional methods employing a B3LYP and the new M06-2X functional were used to study the structure and relative stability of 16 tautomers/rotamers of diphosphocytosine. The dienol tautomers of diphosphocytosine are shown to be much more stable than the keto-enol and diketo forms. The tautomers/rotamers stability could be ranked as PC3 = PC12 < PC2 = PC11 < PC1 < PC10 < PC8 < PC9 < PC15 < PC16 < PC6 ~ PC7 < PC13 < PC4 ~ PC14 < PC5. This stability order was discussed in the light of stereo and electronic factors. Solvation effect has been modeled in a high dielectric solvent, water using the polarized continuum model (PCM). Consideration of the solvent causes some reordering of the relative stability of diphosphocytosine tautomers: PC3 ~ PC12 ~ PC2 ~ PC11 < PC1 < PC10 < PC8 < PC9 < PC15 ~ PC16 < PC13 < PC6 ~ PC7 ~ PC14 < PC4 ~ PC5.
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Alkhasawneh, Mutasem Shabeb. "Software Defect Prediction through Neural Network and Feature Selections." Applied Computational Intelligence and Soft Computing 2022 (September 26, 2022): 1–16. http://dx.doi.org/10.1155/2022/2581832.

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Software failure such as software defect causes billion of dollar loss every year. Software failure also affects billion of people worldwide. Inadequate software testing can cause software failure. To predict the software defect, this study proposed a model consisting of feature selection and classifications. The correlation base method was used for feature selection, and radial base function neural network (RBF) was used for classification. Also, for testing the proposed system, fourteen NASA data sets were used including CM1, JM1, KC1, KC2, KC3, KC4, MC1, MC2, MW1, PC1, PC2, PC3, PC4, and PC5. The data set was divided using the well-known K-cross-validation methods which were performed to divide the data set for training and testing the RBF. The RBF were trained and tested before and after feature selections. Precision, recall, F-measure, and accuracy are four methods used to evaluate the performance of the proposed methods. The precision obtained for the fourteen data sets was CM1, 94.01%; JM1, 85.18%; KC1, 83.24%; KC2, 81.27%; KC3, 79.30%; KC4, 85.29%; MC1, 99.89%; MC2, 73.27%; MW1, 90.90%; PC1, 98.79%; PC2, 100%; PC3, 95.67%; PC4, 95.12%; and PC5, 80.89%. Recall was as follows: CM1, 95.78%; JM1, 87.89%; KC1, 86.24%; KC2, 83.82%; KC3, 82.10%; KC4, 86.28%; MC1, 100%; MC2, 76.67%; MW1, 92.09%; PC1, 99.98%; PC2, 100%; PC3, 96.23%; PC4, 95.17%; and PC5, 81.80%. F-measure was as follows: CM1, 0.95; JM1, 0.87; KC1, 0.83; KC2, 0.82; KC3, 0.85; KC4, 0.86; MC1, 0.99; MC2, 0.76; MW1, 0.95; PC1, 0.99; PC2, 0.99; PC3, 0.97; PC4, 0.95; and PC5, 0.80. The accuracy obtained was as follows: CM1, 93.99%; JM1, 84.87%; KC1, 83.25%; KC2, 79.11%; KC3, 78.25%; KC4, 83.18%; MC1, 99.01%; MC2, 70.18%; MW1, 88.90%; PC1, 98.99%; PC2, 99.80%; PC3, 94.11%; PC4, 94.4%; and PC5, 79.02%. The proposed method results were compared with the result obtained from different methods. The proposed model obtained better results than other methods for data set CM1, KC4, MC1, PC1, PC2, PC3, PC4, and PC5.
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Gibson, Sigrid, and Margaret Ashwell. "Dietary patterns among British adults: compatibility with dietary guidelines for salt/sodium, fat, saturated fat and sugars." Public Health Nutrition 14, no. 8 (May 6, 2011): 1323–36. http://dx.doi.org/10.1017/s1368980011000875.

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AbstractObjectiveTo examine dietary patterns among British adults, associations with Na and macronutrient intakes, and implications for dietary advice.DesignPrincipal component analysis of 7 d weighed dietary records.SubjectsAdults aged 19–64 years (n 1724).SettingNational Diet and Nutrition Survey (2000/2001).ResultsHigh Na intake was associated with more energy-dense diets, higher in fat and SFA (percentage of energy) but lower in non-milk extrinsic sugars (NMES). Eight patterns (PC1 to PC8) explained 40 % of the total variance in food intakes. Three patterns – PC3 (high loadings on bread, fats and cheese), PC2 (meat products, eggs and chips) and PC7 (red meat, sauces and alcohol) – were associated with high Na intake. Of these, PC3 correlated with high Na density and Na:K ratio, while PC2 correlated with fat. By contrast, three patterns – ‘health-conscious’ (PC1; vegetables, fruit, fruit juice, fish), ‘breakfast cereals and milk’ (PC6) and ‘chicken and rice’ (PC8) – were associated with modest Na intake, lower Na density and lower fat and SFA. PC2 was positively correlated, and PC1 was negatively correlated, with adding salt to food. Other patterns were ‘tea/coffee and cakes’ (PC4; associated with high SFA and NMES) and ‘soft drinks and snacks’ (PC5; associated with high NMES but not fat or SFA). The dietary patterns of males and females differed slightly.ConclusionsDietary patterns PC1, PC6, PC8 (vegetables, fruit, fish, milk, breakfast cereals, poultry) were broadly compatible with guidelines for salt, fat, SFA and NMES. However, other patterns tended to be high in either salt or NMES.
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Kondi, Ravi, Sonali Kar, and Soumya Surakanti. "Agro-morphological and biochemical characterization and principal component analysis for yield and quality characters in fine-scented rice genotypes." Genetika 54, no. 3 (2022): 1005–21. http://dx.doi.org/10.2298/gensr2203005k.

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Forty-one fine-scented rice genotypes were evaluated for 18 agro-morphological and quality characters for characterization, and 21 quantitative characters were evaluated for principal component analysis in R-studio software. Characterization of agro-morphological traits viz., plant height, days to 50% flowering, panicle length, number of effective tillers per plant, test weight, grain length, grain breadth, grain L: B ratio, kernel length, kernel breadth, kernel dimensions, awns, colour of awns, distribution of awns, and quality traits viz., alkali spreading value, gel consistency, grain aroma, and amylose content showed huge diversity among the genotypes. PCA revealed that PC1 showed the highest amount of variance (32.0%) followed by PC2 (15.7%), PC3 (9.0%), PC4 (8.1%), PC5 (7.8%), PC6 (5.4%) for quantitative characters. Out of 21 principal components, only 6 showed an eigenvalue greater than 1 and contributes about 78.1% total variance Genotypes in PC1 showed higher values for grain L: B ratio and kernel L: B ratio. Similarly, PC2 showed higher variable values for characters like test weight, kernel length, grain length, grain breadth, alkali spreading value, grain yield per plot and amylose content. PC3 for harvest index, panicle length, gel consistency, no. of effective tillers per plant and head rice recovery. PC4 for characters like plant height, kernel breadth and days to 50% flowering. PC5 for characters like kernel elongation ratio, and filled grains per panicle. PC6 for characters like no. of tillers in a square meter and no. of panicles in a square meter. This pre-breeding characterization study may be useful in finding potential genotypes which are having both yield and quality characters which may be useful in breeding for high-yielding varieties with good-quality characters.
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Jensen, Matt, Trent Stellingwerff, Courtney Pollock, James Wakeling, and Marc Klimstra. "Can Principal Component Analysis Be Used to Explore the Relationship of Rowing Kinematics and Force Production in Elite Rowers during a Step Test? A Pilot Study." Machine Learning and Knowledge Extraction 5, no. 1 (February 17, 2023): 237–51. http://dx.doi.org/10.3390/make5010015.

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Investigating the relationship between the movement patterns of multiple limb segments during the rowing stroke on the resulting force production in elite rowers can provide foundational insight into optimal technique. It can also highlight potential mechanisms of injury and performance improvement. The purpose of this study was to conduct a kinematic analysis of the rowing stroke together with force production during a step test in elite national-team heavyweight men to evaluate the fundamental patterns that contribute to expert performance. Twelve elite heavyweight male rowers performed a step test on a row-perfect sliding ergometer [5 × 1 min with 1 min rest at set stroke rates (20, 24, 28, 32, 36)]. Joint angle displacement and velocity of the hip, knee and elbow were measured with electrogoniometers, and force was measured with a tension/compression force transducer in line with the handle. To explore interactions between kinematic patterns and stroke performance variables, joint angular velocities of the hip, knee and elbow were entered into principal component analysis (PCA) and separate ANCOVAs were run for each performance variable (peak force, impulse, split time) with dependent variables, and the kinematic loading scores (Kpc,ls) as covariates with athlete/stroke rate as fixed factors. The results suggested that rowers’ kinematic patterns respond differently across varying stroke rates. The first seven PCs accounted for 79.5% (PC1 [26.4%], PC2 [14.6%], PC3 [11.3%], PC4 [8.4%], PC5 [7.5%], PC6 [6.5%], PC7 [4.8%]) of the variances in the signal. The PCs contributing significantly (p ≤ 0.05) to performance metrics based on PC loading scores from an ANCOVA were (PC1, PC2, PC6) for split time, (PC3, PC4, PC5, PC6) for impulse, and (PC1, PC6, PC7) for peak force. The significant PCs for each performance measure were used to reconstruct the kinematic patterns for split time, impulse and peak force separately. Overall, PCA was able to differentiate between rowers and stroke rates, and revealed features of the rowing-stroke technique correlated with measures of performance that may highlight meaningful technique-optimization strategies. PCA could be used to provide insight into differences in kinematic strategies that could result in suboptimal performance, potential asymmetries or to determine how well a desired technique change has been accomplished by group and/or individual athletes.
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Kuzmina, O. B., I. V. Khazina, P. V. Smirnov, A. O. Konstantinov, and A. R. Agatova. "Palynological profile and depositional environment of the Ishim formation (upper Miocene) in Tobol-Ishim interfluve, Western Siberia." Стратиграфия 27, no. 6 (December 12, 2019): 103–23. http://dx.doi.org/10.31857/s0869-592x276103-123.

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For the first time some outcrops of the Upper Miocene Ishim Formation on the south of Tyumen Area near Pyatkovo, Masali and Bigila villages are studied by palynological method in detail. A series of mineralogical analyzes of these sediments and radiocarbon analysis of the Quaternary sediments overlying the Ishim Formation are done. Four palynocomplexes (PC) are established in the Ishim Formation: PC1 with Botryococcus; PC2 with Botryococcus, Sigmopollis; PC3 with Alnus, Polypodiaceae, Botryococcus, Sigmopollis; PC4 with Betula, Alnus, Corylus. The layers with PC1, PC2 и PC3 are traced in two outcrops near Masali and Bigila Villages. PC4 is revealed from the sands and aleuropelits of the outcrop near Pyatkovo Village, it is characterized by a significant content of diverse pollen of temperate termophylic broad-leafed taxa and by the presence of rare typical Miocene elements (Таxodiaceae, Nyssa, Tsuga). The PC3 and PC4 are compared with the complexes well known from the Neogene sediments of Western Siberia. PC5 with Betula, Herbae, Fungi is revealed from the bedded silts overlying the Ishim Formation in Masali outcrop. Previously, these sediments were attributed to the Late Miocene Pavlodar Formation. The composition and the structure of PC5 allowed making an assumption about Quaternary age of the enclosing sediments. Radiocarbon analysis of the organic substance from the silts showed, that these sediments were accumulated in the Late Pleistocene (Sartan Ice Age). For the first time the information about microphytoplankton (Botryococcus, Pediastrum, Zygnemataceae, Sigmopollis) and other nonpollen palynomorphs, contained in Ishim Formation (Upper Miocene) and in Pleistocene sediments, is given. On palynological data, some stages of development of the Late Miocene Ishim Basin and the type of vegetation surrounding this basin are considered. The depositional environment of Pleistocene sediments (Masali outcrop) is reconstructed.
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M. Saleh, Maysoun, Abdelmoaty B. Elabd, and Abdel Rahman Mohammad Al Tawaha. "Principle Component Analysis among Exotic and Egyptian Rice Genotypes." Advances in Environmental Biology 15, no. 1 (January 1, 2007): 16–22. http://dx.doi.org/10.22587/aeb.2021.15.1.3.

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Twenty-five rice genotypes with two Egyptian rice varieties: Giza 178 and Sakha 105 were all cultivated in a Randomized Complete Block Design (RCBD) with two replications under saline soil at at El_Sirw Agriculture Research Station northern part of Delta, Egypt during the growing season 2012. This study aimed to evaluate the potential divergence among tested genotypes and to define the role of agronomic traits in the total variation by using principle component analysis. Results showed that high variability was noticed between the testes genotypes, and indicated that only four principle components PC1, PC2, PC3 and PC4 were significant as they had an Eigenvalue greater than 1.0 (2.3967, 2.1444, 1.7225, 1.0618) respectively, explained together 73.3% of existed variation between genotypes. The first principle component PC1 explained the highest variation 24%, followed by other components PC2, PC3 and PC4 which explained (21.4, 17.2, 10.6) % of the total variation. Results also revealed that days to flowering and number of filled grains per panicle were associated with PC1, whereas three traits (tillers per plant, panicles number per plant and thousand grain weight) were gathered in PC2, and the PC3 consisted of (panicle length, panicle fertility and grain yield per plant), while the last component PC4 contained both traits flag leaf area and plant height. It was concluded that the divergence between rice genotypes in our study provide a wide genetic base for breeders to improve rice
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Abarza, Liliann, Pablo Acuña-Mardones, Cristina Sanzana-Luengo, and Víctor Beltrán. "Determination of Morphogeometric Patterns in Individuals with Total Mandibular Edentulism in the Interforaminal Region from Cone Beam Computed Tomography (CBCT) Scans: A Pilot Study." Applied Sciences 12, no. 8 (April 10, 2022): 3813. http://dx.doi.org/10.3390/app12083813.

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The aim of this study was to determine the morphogeometric patterns of the interforaminal region from cone beam computed tomography (CBCT) scans of individuals with total mandibular edentulism. CBCT images were obtained from 40 patients with total edentulism who are older (12 men and 28 women; average age of 69.5 ± 9.4 years) and who wore a non-implant-supported, lower, removable, total prosthesis. We conducted a two-dimensional (2D) morphogeometric analysis of the Digital Imaging and Communication in Medicine (DICOM) files from the CBCT scans, and five equidistant cross sections were planned. For the three-dimensional (3D) morphogeometric analysis, standard triangular language (STL) files were obtained after segmentation of the interforaminal mandibular region, and four anatomical landmarks and their respective curves were digitized. The patterns among the shapes were determined using principal component analysis (PCA) on MorphoJ software (version 1.07a). The results of the 2D morphogeometric analyses for PCA of the interforaminal mandibular paramedian region were PC1 or elongated drop shape, 54.78%; PC2 or wineskin shape, 17.65%; PC3 or pear shape, 11.77%; and PC4 or eggplant shape, 5.71%, and those for PCA of the symphyseal region were PC1 or elongated drop shape, 62.13%; PC2 or ovoid shape, 11.64%; PC3 or triangular shape, 9.71%; and PC4 or tuber shape, 4.96%. The results of the 3D morphogeometric analyses for the interforaminal hemimandibular region were PC1, 59.83%; PC2, 10.39%; PC3, 7.67%; and PC4, 5.09%. This study provides relevant information for future clinical guidelines on prosthetics and implants, in addition to proposing the use of new technologies that support diagnosis and treatment in patients with edentulism.
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A.A.S., Shamsuddin, and D. Ghosh. "Fracture network Based on Principal Component Analysis and Neural Network– A case study in the Malay Basin." International Journal of Engineering & Technology 7, no. 3.32 (August 26, 2018): 62. http://dx.doi.org/10.14419/ijet.v7i3.32.18394.

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Finding oil in the fractured basement rock in South East Asia has been a goal for several decades, but remains a challenge in terms of exploration/production areas in the Malay Basin due to geological complexity including fracture. Thus, the purpose of this study is to delineate fracture network based on the geometrical attributes in order to have better fracture understanding. In this study, the top of the basement acts as the key surface incorporated with the combination of geometrical seismic attributes analysis. The analysis started with data conditioning and seismic interpretation of the key surface. The final steps were conducted by using geometrical seismic attributes, principal component analysis and neural network. Principal component analysis of these four seismic attributes is able to delineate the contribution of each attributes based on eigenvalue with the PC0: 1.3450 (33.63%), PC1:1.0556 (26.39%), PC2:0.9270 (23.17%) and PC3:0.6724 (16.81%). While neural network contributes four main results (i) PC0 (ii) PC0 and PC1 (iii) PC0, PC1 and PC2 (iv) PC0, PC1, PC 2 and PC3. Fracture networks were able to be delineated and geological features that might be overlooked were able to be captured and can be used to guide the fracture network inside the fractured basement.
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Wang, Zixiong, Tianxiang Wang, Xiaoli Liu, Suduan Hu, Lingxiao Ma, and Xinguo Sun. "Water Level Decline in a Reservoir: Implications for Water Quality Variation and Pollution Source Identification." International Journal of Environmental Research and Public Health 17, no. 7 (April 1, 2020): 2400. http://dx.doi.org/10.3390/ijerph17072400.

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Continuous water-level decline makes the changes of water quality in reservoirs more complicated. This paper uses trend analyses, wavelet analysis and principal component analysis-multiple linear regression to explore the changes and pollution sources affecting water quality during a period of continuous reservoir water level decline (from 65.37 m to 54.15 m), taking the Biliuhe reservoir as an example. The results showed that the change of water level of Biliuhe reservoir has a significant 13-year periodicity. The unusual water quality changes during the low water level period were as follows: total nitrogen continued to decrease. And iron was lower than its historical level. pH, total phosphorus, and ammonia nitrogen were higher than historical levels and fluctuated seasonally. Permanganate index increased as water level decreased after initial fluctuations. Dissolved oxygen was characterized by high content in winter and relatively low content in summer. The pollutant sources of non-point source pollution (PC1), sediment and groundwater pollution (PC2), atmospheric and production & domestic sewage (PC3), other sources of pollution (PC4) were identified. The main source of DO, pH, TP, TN, NH4-N, Fe and CODMn were respectively PC3 (42.13%), PC1 (47.67%), PC3 (47.62%), PC1 (29.75%), PC2 (47.01%), PC1 (56.97%) and PC2 (50%). It is concluded that the continuous decline of water level has a significant impact on the changes and pollution sources affecting water quality. Detailed experiments focusing on sediment pollution release flux, and biological action will be explored next.
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Dissertations / Theses on the topic "PC3"

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Jermany, Joanne Lorna. "Biosynthesis and maturation of the prohormone convertases PC3 and PC2." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295620.

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The prohormone convertases PC2 and PC3 are members of the highly conserved subtilisin-like serine protease superfamily. Targeted to the regulated secretory pathway of neuroendocrine cells they are involved in the proteolytic processing of a number of co-secreted polypeptides. To investigate the nature of their biosynthesis, maturation and possible interaction with the neuroendocrine polypeptide 7B2, a series of mutants were constructed and translated in a novel cell-free in vitro translation/translocation system derived from Xenopus eggs. It was shown that PC3 undergoes rapid (T1/2<10min), autocatalytic maturation, optimally at pH7, in a calcium-independent manner, from an 88kDa proform to an 80kDa mature form, in a proteolytic reaction occurring carboxy-terminal to RSKR83. This indicates the endoplasmic reticulum as the sub-cellular location for PC3 maturation in vivo. Conversely, PC2 matures optimally at pH5.5 in an autocatalytic reaction dependent on millimolar calcium. It was demonstrated that mutation of the PC2 unique oxyanion aspartate282 to asparagine increased its optimal processing pH requirements from acidic to neutral, in a reaction still dependent on millimolar calcium. This infers that the oxyanion aspartate of PC2 influences the pH at which the protease matures. In vitro the role of the neuroendocrine precursor 7B2 in PC2 biosynthesis was shown to be two-fold and pH-dependent. At acidic pH, pro-7B2 acted as an inhibitor of pro-PC2 maturation, whereas under neutral pH conditions pro-7B2 was seen to markedly enhance pro-PC2 maturation. Neither precursor nor mature 7B2 were shown to interact with the PC2 oxyanion mutant, pro- or mature PC3 in vitro. This is consistent with the proposed view that 7B2 specifically interacts with PC2 in the regulated secretory pathway and the association is dependent upon the nature of the PC2 oxyanion aspartate residue.
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Rose, Douglas, Leonard Brian Cross, and Ivy A. Click. "The Patient-Centered Care Committee (PC3)." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/6396.

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Piassi, Amanda Resende. "Análise de pulsações magnéticas Pc3 e Pc4 na região da Anomalia Magnética do Atlântico Sul." Instituto Nacional de Pesquisas Espaciais (INPE), 2018. http://urlib.net/sid.inpe.br/mtc-m21c/2018/05.02.17.17.

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O Campo Magnético Terrestre apresenta algumas características específicas no continente sul-americano, incluindo uma região onde se observa uma diminuição significativa em sua intensidade. Essa região é chamada de Anomalia Magnética do Atlântico Sul (SAMA), na qual uma aproximação do cinturão interno de radiação resulta em significativa precipitação de partículas energéticas na atmosfera. Essa precipitação de partículas aumenta a condutividade elétrica em grande parte da ionosfera sul-americana, produzindo efeitos aeronômicos peculiares. Este trabalho teve como objetivo estudar os efeitos da SAMA nas pulsações geomagnéticas Pc3 e Pc4 registradas por magnetômetros de núcleo saturado operados pelo Programa de Estudo e Monitoramento Brasileiro do Clima Espacial(EMBRACE) e pela rede global INTERMAGNET em diferentes estações magnéticas terrestres. Os dados foram utilizados para avaliar efeitos produzidos durante períodos geomagneticamente calmos e perturbados no ano de 2015. Exceto por um resultado anômalo observados para as Pc3 durante um período calmo no equinócio de outono(março), possivelmente associado ao aumento no conteúdo eletrônico total, as amplitudes das pulsações mostraram uma amplificação consistente na SAMA, sendo o maior fator de amplificação observado próximo da região central da anomalia. Um modelo genérico é sugerido como fonte das pulsações, o qual inclui a geração de ondas superficiais por instabilidades de plasma nos limites de alta latitude da magnetosfera diurna, a propagação dessas ondas pelas linhas de campo geomagnético até latitudes polares e o subsequente vazamento das correntes geradas em direção a latitudes mais baixas por um guia de ondas terra-ionosfera. A transmissão horizontal desses campos polares pela SAMA é influenciada por variações da condutividade ionosférica e gera pulsações geomagnéticas com amplitudes diferentes em função da distância ao centro da anomalia.
The Earths magnetic field presents some specific characteristics in the South American continent, including a region where a significant decrease in intensity is observed. This region is called the South Atlantic Magnetic Anomaly (SAMA), at which an approximation of the internal radiation belt results in enhanced precipitation of energetic particles into the atmosphere. This particle precipitation increases the electrical conductivity in much of the South American ionosphere, producing peculiar aeronomic effects. This work aimed to study the effects of SAMA on Pc3 and Pc4 magnetic pulsations recorded by fluxgate magnetometers operated by the Brazilian Studies and Monitoring of Space Weather (EMBRACE) and by the INTERMAGNET global network in different ground stations. The data were used to evaluate effects produced during magnetically quiet and disturbed periods in the year 2015. Except for an anomalous result observed for Pc3 during a quiet interval at the March equinox, possibly associated with the increase in Total Electronic Content, pulsation amplitudes showed a consistent amplification in SAMA, being the largest amplification factors observed near the central region of the anomaly. A generic model is suggested as the source of the pulsations, which includes the generation of surface waves by plasma instabilities at the dayside high-latitude magnetosphere boundary, the propagation of these waves through magnetic field lines until polar latitudes and the subsequent leakage of the currents toward lower latitudes by an Earthionosphere waveguide. The horizontal transmission of these polar fields through the SAMA is influenced by variations of ionospheric conductivity and generates ground geomagnetic pulsations with different amplitude as a function of the distance to the center of the anomaly.
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Scougall, Kathleen. "Maturation of pro-hormone convertases PC2 and PC3 and their interaction with the neuroendocrine protein 7B2." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301302.

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The activation of many pro-hormones occurs through cleavage at pairs of basic residues and is mediated by two serine proteases, PC2 and PC3. Like their substrates, they are also synthesised as inactive precurors (pro-PC2 and pro-PC3). Maturation is autocatalytic and requires removal of the N-terminal pro-peptide. Pro-PC3 matures within the endoplasmic reticulum (ER), whereas maturation of pro-PC2 proceeds within the later compartments of the Golgi network (TGN)/secretory vesicle (SV) and is thought to be regulated by 7B2. In this study the molecular basis for the differences in the maturation location and the interaction with 7B2 was examined by performing domain swap and site directed mutagenesis experiments. The mutant constructs were analysed within an in vitro cell free system. The results suggest that the oxyanion hole residue (Asp310) of pro-PC2 restricts maturation to a late secretory compartment and is important for the interaction with 7B2. Mutation of this residue to resemble that of PC3 (Asp310Ans), altered pro-PC2 maturation from a TGN/SV like environment to an ER like environment. Maturation of pro-PC2, but not pro-PC3, was shown to be inhibited by 7B2. Residue Asp310 of PC2 was necessary to mediate this interaction. When a similar mutant of PC3 was created to resemble PC2 (Asn309Asp), this residue was not sufficient to alter the maturation profile of pro-PC3 nor was it able to confer 7B2 sensitivity. The pro-region of PC2 was sufficient to alter maturation of PC3 from the ER-like compartment to a TGN/SV-like compartment, but was not able to confer 7B2 sensitivity onto PC3. This study also demonstrated that a basic cluster (HHKQQ88) of pro-PC2 was important for delaying maturation to a late compartment and that the residue Phe104, was important for efficient maturation. Mutational analysis of pro-7B2 revealed that a region within residues 1-151 was important for the interaction with pro-PC2.
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Davoodpour, Padideh. "2-ME-Induced Apoptotic Signalling in Prostate Cancer PC3 Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6136.

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Lotz, Stefanus Ignatius. "Empirical modelling of the solar wind influence on Pc3 pulsation activity." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1005249.

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Geomagnetic pulsations are ultra-low frequency (ULF) oscillations of the geomagnetic field that have been observed in the magnetosphere and on the Earth since the 1800’s. In the 1960’s in situ observations of the solar wind suggested that the source of pulsation activity must lie beyond the magnetosphere. In this work the influence of several solar wind plasma and interplanetary magnetic field (IMF) parameters on Pc3 pulsations are studied. Pc3 pulsations are a class of geomagnetic pulsations with frequency ranging between 22 and 100 mHz. A large dataset of solar wind and pulsation measurements is employed to develop two empirical models capable of predicting the Pc3 index (an indication of Pc3 intensity) at one hour and five minute time resolution, respectively. The models are based on artificial neural networks, due to their ability to model highly non-linear interactions between dependent and independent variables. A robust, iterative process is followed to find and rank the set of solar wind input parameters that optimally predict Pc3 activity. According to the parameter selection process the input parameters to the low resolution model (1 hour data) are, in order of importance, solar wind speed, a pair of time-based parameters, dynamic solar wind pressure, and the IMF orientation with respect to the Sun-Earth line (i.e. the cone angle). Input parameters to the high resolution model (5 minute data) are solar wind speed, cone angle, solar wind density and a pair of time-based parameters. Both models accurately predict Pc3 intensity from unseen solar wind data. It is observed that Pc3 activity ceases when the density in the solar wind is very low, even while other conditions are favourable for the generation and propagation of ULF waves. The influence that solar wind density has on Pc3 activity is studied by analysing six years of solar wind and Pc3 measurements at one minute resolution. It is suggested that the pause in Pc3 activity occurs due to two reasons: Firstly, the ULF waves that are generated in the region upstream of the bow shock does not grow efficiently if the solar wind density is very low; and secondly, waves that are generated cannot be convected into the magnetosphere because of the low Mach number of the solar wind plasma due to the decreased density.
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Santos, Geyza Spigoti. "Avaliação do efeito radiomodificador da própolis em células de ovário de hamster chinês (CHO-K1) e em células tumorais de próstata (PC3), irradiadas com CO-60." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-26082011-100451/.

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Nestas últimas décadas, investigações sobre compostos naturais, efetivos, não tóxicos, com potencial radioprotetor vêm despertando um grande interesse em consonância com a utilização crescente de vários tipos de radiação ionizante nas mais diversas finalidades. Entre eles a própolis uma resina coletada pelas abelhas (Apis mellifera), vem sendo apontada como promissora por apresentar uma série de características biológicas vantajosas, por exemplo, anti-inflamatória, antimicrobiana, antitumoral, imunomoduladora, antioxidante e também scavenger de radicais livres. O presente estudo teve como objetivo principal, averiguar efeito da própolis brasileira procedente de Rio Grande do Sul (AF 08) em células de ovário de hamster Chinês (CHO-K1) e em células tumorais de próstata (PC3), irradiadas com 60Co. Para tanto, foram utilizados três principais parâmetros interligados entre si: indução de micronúcleo, viabilidade celular e morte clonogênica. A escolha destes parâmetros se justifica pelo seu significado biológico, além do fato de serem prontamente observáveis e mensuráveis em células irradiadas. Os dados citogenéticos obtidos, mostraram um efeito radioprotetor da própolis (5 - 100 μg/ml) na indução de dano ao DNA em ambas as linhagens celulares, irradiadas com doses de 1 - 4 Gy. No entanto, o ensaio de citotoxicidade mostrou um efeito antiproliferativo pronunciado da própolis (50 - 400 μg/ml) em células PC3 irradiadas com 5 Gy. As curvas de sobrevida obtidas foram ajustadas satisfatoriamente pelo modelo linear-quadrático, cujo componente foi mais alto em células CHO-K1. Quanto à capacidade clonogênica, as células PC3 mostraram-se mais radiossensíveis que as células CHO-K1 nas doses mais altas da curva de sobrevida. A própolis, nas concentrações de 30 - 100 μg/ml, não influenciou no potencial clonogênico das células PC3, visto que, as curvas de sobrevida associadas ou não com a própolis, mostraram perfis similares, ao passo que o tratamento combinado em células CHO-K1 exibiu um efeito estimulador da proliferação. Os dados obtidos in vitro mostraram um potencial uso da própolis AF-08, como uma substância natural e não tóxica, na prevenção contra os efeitos danosos da radiação ionizante, nas doses e nas concentrações analisadas.
In the last decades, it has been given a great interest to investigations concerning natural, effective, nontoxic compounds with radioprotective potential together with the increasing utilization of different types of ionizing radiation for various applications. Among them propolis, a resinous compound produced by honeybees (Apis mellifera), has been considered quite promising, since it presents several advantageous biological characteristics, i. e., anti-inflammatory, antimicrobial, anticarcinogenic, antioxidant and also free radical scavenging action. The purpose of the present study was to evaluate the effect of Brazilian propolis, collected in the State of Rio Grande do Sul, on Chinese hamster ovary (CHO-K1) and human prostate cancer (PC3) cells, irradiated with 60Co radiation. For this purpose, three interlinked parameters were analyzed: micronucleus induction, cell viability and clonogenic death. The choice of these parameters was justified by their biological significance, in addition to the fact that they are readily observable and measurable in irradiated cells. The cytogenetic data obtained showed a radioprotective effect of propolis (5-100 μg/ml) in the induction of DNA damage for both cell lines, irradiated with doses of 1 - 4 Gy. The cytotoxicity assay, however, showed a prominent antiproliferative effect of propolis (50 - 400 μg/ml) in PC3 cells irradiated with 5 Gy. The survival curves obtained were adequately fitted by a linear-quadratic model, where the coefficient was higher in CHO-K1 cells. Concerning the clonogenic capacity, PC3 cells were more radiosensitive than CHO-K1 cells at the higher doses of the survival curve. Propolis at the concentrations of 30 - 100 μg/ml, did not influence the clonogenic potential of PC3 cells, since the survival curves, associated or not with propolis, were found similar, although the combined treatment in CHO-K1 cells exhibited a stimulating proliferative effect. The data obtained in vitro showed a potential use of propolis AF-08, a natural and nontoxic compound, in the prevention against the adverse effect of ionizing radiation, at the doses and concentrations here analyzed.
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Zanandrea, Ademilson. "Estudos de micropulsacoes geomagneticas PC3-5 em latitudes muito baixas, no Brasil." Instituto Nacional de Pesquisas Espaciais (INPE), 1998. http://urlib.net/sid.inpe.br/deise/1999/10.14.15.11.

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Neste estudo, procurou-se compreender os mecanismos de geracao e modos de propagacao de micropulsacoes Pc3-5, em latitudes muito baixas e equatoriais. Usou-se dados simultaneos observados com uma cadeia de 10 estacoes geomagneticas. no territorio brasileiro, dispondo de magnetometros ""fluxgate"" de alta sensibilidade. Utilizou-se o metodo de estimacao espectral por multiplas janelas, baseado na Transformada Rapida de Fourier (FFT), para obter os espectros de potencia, parametros de polarizacao e fase das micropulsacoes. Observou-se um aumento na ocorrencia das pulsacoes Pc3-5 altamente polarizadas, atingindo o maximo proximo ao meio-dia local (14:00 e 15:00 UT) nas estacoes mais proximas ao equador magnetico. Os espectros dinamicos mostraram a ocorrencia de 81 eventos simultaneos de pulsacoes Pc3-4 com alto grau de polarizacao, principalmente durante o dia. Os eventos diurnos mostraram um aumento de 3,2 vezes na densidade de potencia polarizada para as pulsacoes observadas nas estacoes proximas do equador magnetico em comparacao com as mais distantes. As fases das pulsacoes mostraram atrasos entre 48' e 62' nas estacoes equatoriais em relacao as mais distantes. Estes efeitos estao relacionados ao aumento da condutividade ionosferica e da intensidade de eletrojato equatorial. As curvas de densidade de potencia polarizada para as 10 estacoes mostraram um comportamento identico, com picos maximos ocorrendo na mesma frequencia. Isto esta possivelmente relacionado ao modo de oscilacao global da cavidade plasmasferica. A elipticidade mostrou-se quase-linear, com eixo maior na direcao norte-sul, devido ao fato de que as oscilacoes poloidais das linhas de campo magneticas sao quase desacopladas. A amplitude da componente norte-sul mostrou-se maior que a oeste-leste. Estes resultados sao uma evidencia de que o mecanismo da ressonancia das linhas de campo nao explica as micropulsacoes Pc3-4 observadas em latitudes muito baixas e equatoriais. O aumento na ocorrencia de eventos Pc3-4 durante o dia., com maximo proximo ao meio-dia local e presenca predominante do modo poloidal (compressional), esta provavelmente associado com a propagacao da onda compressional, proveniente da instabilidade ion-ciclotronica na regiao da frente de choque, que se propaga na magnetosfera em baixas latitudes. A propagacao desta onda pode excitar o modo compressional aprisionado ou o modo global compressional. O fenomeno resultante, das oscilacoes forcadas das linhas de campo na plasmasfera, e o mais provavel mecanismo fonte das pulsacoes Pc3-4 em latitudes muito baixas e equatoriais.
This study is aimed at the understanding of source mechanisms and propagation modes of Pc3-5 micropulsations at very low and equatorial latitudes. It used simultaneous data measured with a chain of 10 geomagnetic stations in Brazil using high sensitive °uxgate magnetometers. Multiple tapered spectral estimation method based on Fast Fourier Transforms (FFT) was used to obtain micropulsation power spectra, polarization parameters and phases. It was observed an increase on the occurrence of highly polarized Pc3-5 pulsations, reaching maxima close to local noon (14:00 and 15:00 UT) in the stations nearest to the magnetic equator. The dynamic spectra showed the occurrence of 81 simultaneous events of Pc3-4 pulsations with high degree of polarization, mainly during daytime. The diurnal events showed increases in the polarized power density of 3,2 times for pulsations observed at stations close to the magnetic equator in comparison to the more distant ones. The phase of the pulsations observed at station close of the magnetic equator showed a delay of 48± and 62± in relation to the most distant one. This e®ects is clearly related to the increase of ionospheric conductivity and equatorial electrojet intensity. The polarized power density curves for all the 10 stations showed a similar behaviour, the maximum peaks occurring at same frequency. This may indicate a possible link to the plasmaspheric cavity global oscillation mode. The ellipticity was quase-linear, with the arger axis in the north-south direction, due to the fact that the poloidal mode is almost uncoupled from the oscillation of magnetic ¯eld lines. The amplitude of north-south component is much larger than the west-east one. These results could be an evidence that field line resonance mechanism does not explain Pc3-5 micropulsations observed at very low and equatorial latitudes. The increase in the occurrence of Pc3-4 diurnal events is probably associated with incoming compressional waves resulted from bow shock ion cyclotron instabilities that propagate in the magnetosphere at low latitudes. The propagation of the compressional waves may excite the trapped compressional mode or the compressional global mode. The resulting phenomenon, field lines forced oscillations in the plasmasphere, may be a possible source mechanism for Pc3-4 pulsations at very low latitudes.
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Bugiel, Steven. "β1 Integrin Regulates PC3 Prostate Cancer Cell Phenotypes in part via Regulation of Matricellular SPARC." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34785.

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We have shown herein that β1 integrin stably depleted PC3 sub-clonal cells confer a trend towards increased survival of mice compared to β1 integrin expressing counterparts when tested in an intracardial bone metastasis model. Therefore, we sought to investigate novel factors that mediate β1 integrin-dependent cellular migration and three dimensional growth of prostate cancer PC3 cells in vitro. We show herein that depletion of β1 integrin using siRNA directed techniques results in increased SPARC protein expression. We further show that suppression of SPARC by β1 integrin appears to occur through a JNK dependent mechanism. Moreover, siRNA mediated depletion of β1 integrin results in impaired sphere formation in 3D BME assays. This was mediated in part by the increased production of SPARC. β1 integrin-depleted cells also diminished the enhanced migration of cells on the predominant bone matrix, collagen I. Concomitant SPARC depletion in β1 integrin-depleted cells did not rescue this enhanced migration. These findings suggests that the role of β1 integrin in mediating 3D growth of PC3 cells occurs at least in part through the suppression of SPARC protein expression.
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Andrews, Natalie M. "Beta1 integrin modulates the anchorage independent growth, invasion and migration of prostate cancer cell line PC3." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28850.

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Integrins provide mechanical continuity between the extra- and intracellular environments. Upon binding to extracellular matrix (ECM), integrins interact with downstream effectors to promote cell adhesion, proliferation and migration. In contrast to its well-known role in adhesion, we have found that beta 1 integrin is also involved in the anchorage independent (AI) growth of prostate tumor cells. In concurrence with our previous findings, stable depletion of beta1 integrin in PC3 cells using an shRNA approach resulted in the complete inability of cells to form colonies in soft agarose, while adherent monolayer growth remained unaffected. In order to address the mechanism for beta1 integrin dependent AI growth, we examined the expression and localization of beta-catenin and E-cadherin, both of which are known to modulate AI growth. Migration and invasion through matrigel were found to be impeded by depletion of beta1 integrin. A qPCR array identified potential downstream targets that could be altered as a result of beta1 integrin depletion, these were further examined in all cell lines and it was found that TGFbeta1 is reduced in shITGB1 expressing cells. Taken together, these findings suggest a role for both beta1 integrin in driving anchorage independent growth and invasion of cancer cells.
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Books on the topic "PC3"

1

Repubbliche rosse: I simboli nazionali del Pci e del Pcf (1944-1953). Bologna: CLUEB, 2009.

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Steve, Prokup, ed. Cellular and PCS/PCN telephones and systems: An overview of technologies, economics, and services. Fuquay-Varina, NC: APDG Pub., 1996.

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Newton, C. R. PCR. Oxford: BIOS Scientific in association with the Biochemical Society, 1994.

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Kotecha, Harshad. PCs. New York: Barnes & Noble Books, 2005.

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p53. Austin, Texas, USA: Landes Bioscience, 2011.

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Newman, Gerald. PCP. Springfield, NJ: Enslow Publishers, 1997.

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McPherson, M. J. PCR. Oxford: BIOS Scientific Publishers, 2000.

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Ayed, Ayeda, and Theodore Hupp. p53. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-8231-5.

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Domingues, Lucília, ed. PCR. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7060-5.

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PCP. San Diego, Calif: Lucent Books, 2005.

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Book chapters on the topic "PC3"

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Saidak, Zuzana, Zakaria Ezzoukhry, Jean-Claude Maziere, Antoine Galmiche, Ken-Ichi Takemaru, Xingwang Chen, Feng-Qian Li, et al. "BTG2 (TIS21, PC3)." In Encyclopedia of Signaling Molecules, 209. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100142.

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Olson, John V., and Brian J. Fraser. "Pc3 Pulsations in the Cusp." In Solar Wind Sources of Magnetospheric Ultra-Low-Frequency Waves, 325–34. Washington, D. C.: American Geophysical Union, 2013. http://dx.doi.org/10.1029/gm081p0325.

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McKeon, Frank, and Annie Yang. "P53, P63, and P73: Internecine Relations?" In 25 Years of p53 Research, 209–22. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-2922-6_9.

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Magerko, Brian. "The PC3 Framework: A Formal Lens for Analyzing Interactive Narratives across Media Forms." In Interactive Storytelling, 103–12. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12337-0_10.

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Engebretson, M. J., L. J. Cahill, R. L. Arnoldy, and B. J. Anderson. "Studies of Pc 1-Pc3 Geomagnetic Pulsations at High Southern Latitudes: Implications for origin and Transmission." In Electromagnetic Coupling in the Polar Clefts and Caps, 187–201. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-0979-3_13.

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Potapov, A. S., and V. A. Mazur. "Pc3 Pulsations: From the Source in the Upstream Region to Alfven Resonances in the Magnetosphere. Theory and Observations." In Solar Wind Sources of Magnetospheric Ultra-Low-Frequency Waves, 135–45. Washington, D. C.: American Geophysical Union, 2013. http://dx.doi.org/10.1029/gm081p0135.

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Monti, Olimpia, Alexander Damalas, Sabrina Strano, and Giovanni Blandino. "P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells." In 25 Years of p53 Research, 223–32. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-2922-6_10.

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Inoue, Kazushi, and Elizabeth A. Fry. "Alterations of p63 and p73 in Human Cancers." In Subcellular Biochemistry, 17–40. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9211-0_2.

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Quenum, Gandome Mayeul L. D., Nana A. B. Klutse, Eric A. Alamou, Emmanuel A. Lawin, and Philip G. Oguntunde. "Precipitation Variability in West Africa in the Context of Global Warming and Adaptation Recommendations." In African Handbook of Climate Change Adaptation, 1533–54. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45106-6_85.

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AbstractIt is commonly accepted that the Earth’s climate is changing and will continue to change in the future. Rising temperatures are one of the direct indicators of global climate change. To investigate how the rising global temperature will affect the spatial pattern of rainfall in West Africa, the precipitation and potential evapotranspiration variables from ten Global Climate Models (GCMs) under the RCP8.5 scenario were driven by the Rossby Centre regional atmospheric model (RCA4) from the COordinated Regional Climate Downscaling EXperiment (CORDEX) and analyzed at four specific global warming levels (GWLs) (i.e., 1.5 °C, 2.0 °C, 2.5 °C, and 3.0 °C) above the preindustrial level. This study utilized three indices, the precipitation concentration index (PCI), the precipitation concentration degree (PCD), and the precipitation concentration period (PCP) over West Africa to explore the spatiotemporal variations in the characteristics of precipitation concentrations. Besides, the analysis of the effect of the specified GWLs on the Consecutive Dry Days (CDD), Consecutive Wet Days (CWD), and frequency of the intense rainfall events allowed to a better understanding of the spatial and temporal patterns of extreme precipitation in West Africa. Results reveal that, for the projections simulations and at each GWL, the rainfall onset starts one month earlier in the Gulf of Guinea in response to the control period. To encourage adaptation to the various changes in climate in general, and particularly in respect of rainfall, this study proposes several adaptation methods that can be implemented at the local (country) level, as well as some mitigation and adaptation strategies at the regional (West African) level.
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Olivier, Magali, Audrey Petitjean, Claude de Caron Fromentel, and Pierre Hainaut. "TP53 Mutations in Human Cancers: Selection versus Mutagenesis." In p53, 1–18. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-8231-5_1.

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Conference papers on the topic "PC3"

1

Cardinal, M. G., and K. Yumoto. "Characteristics of equatorial Pc3 pulsations." In 2009 International Conference on Space Science and Communication (IconSpace). IEEE, 2009. http://dx.doi.org/10.1109/iconspace.2009.5352676.

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive scaffolds being investigated for their antitumor activities. Three series of 18 cyclic (tetralone-based) and two acyclic chalcone analogs, in which ring B was either substituted with nitrogen mustard or replaced by pyrrole or pyridine heterocyclic rings, were designed, synthesized and evaluated as potential therapies for CRPC. Compounds were synthesized by Claisen-Schmidt condensation reaction, purified using columnchromatography or recrystallization and characterized by 1H-NMR, 13C-NMR and LC-MS. The compounds' in-vitro cytotoxicity was evaluated against three prostate cancer cell lines (PC3, DU145, and LNCaP). Among the tested compounds, OH14, OH19 and OH22 showed potent antiproliferative activities at low micromolar levels with IC50 values ranging between 4.4 and 10 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule OH19 revealed that it significantly induces apoptosis through upregulation of Bax and downregulation of BCL-2. In addition, OH19 potently inhibits colony formation and reduces cell migration of androgen-independent PCa cell lines (PC3 and DU145). The molecular pathway analysis show that the anticancer activity of OH19 is associated with attenuation in the phosphorylation of Akt and ERK. Furthermore, OH19 inhibits blood vessel formation in the chick chorioallantoic membrane (CAM) model as compared to control. These results indicate that OH19 could serve as a potential promising lead molecule for the treatment of CRPC and thus, further in-vitro and invivo studies are warranted.
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Hussein, Ola, Feras Alali, Ala‐Eddin Al Mustafa, and Ashraf Khalil. "Development of Novel Chalcone Analogs as Potential Multi-Targeted Therapies for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0114.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, castration-resistant prostate cancer (CRPC). Therefore, the objective of this study was to discover and develop novel treatment modalities for CRPC. Chalcones are among the highly attractive scaffolds being investigated for their antitumor activities. A library of 26 chalcone analogs were designed, synthesized and evaluated as potential therapies for CRPC. The design was guided by in-silico ADMET prediction in which analogs with favorable drug-likeness properties were prioritized. The new compounds were synthesized, purified and characterized by extensive structural elucidation studies. The compounds in vitro cytotoxicity was evaluated against two androgen receptor (AR)-negative prostate cancer cell lines (PC3 and DU145). Among the tested compounds, pyridine containing analogs (13, 15 and 16) showed potent antiproliferative activities with IC50 values ranging between 4.32-6.47 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule 16 revealed that it can significantly induce apoptosis through upregulation of Bax and downregulation of Bcl-2. In addition, compound 16 potently inhibited colony formation and reduced cell migration of AR-negative PCa cell lines (PC3 and DU145). The molecular pathway analysis showed that the anticancer activity of compound 16 is associated with blocking of ERK1/2 and Akt activities. Furthermore, compound 16 inhibited angiogenesis in the chick chorioallantoic membrane (CAM) model as compared to control. Structure-activity relationship study revealed that the cytotoxicity could dramatically improve via changing the methoxylation pattern by more than 2-folds (IC50 << 2.5 μM). These results indicate that pyridine-based chalcones could serve as promising lead molecules for the treatment of CRPC; thus, further in vitro and in vivo studies are warranted.
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Lotz, Stefan, Lee-Anne McKinnell, and Peter Sutcliffe. "Pc3 pulsations during low density solar wind events." In 2011 XXXth URSI General Assembly and Scientific Symposium. IEEE, 2011. http://dx.doi.org/10.1109/ursigass.2011.6051013.

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Zanandrea, A., J. M. da Costa, S. L. G. Dutra, and N. B. Trivedi. "Micropulsações Geomagnéticas Pc3-4 Em Latitudes Muito Baixas, No Brasil." In 6th International Congress of the Brazilian Geophysical Society. European Association of Geoscientists & Engineers, 1999. http://dx.doi.org/10.3997/2214-4609-pdb.215.sbgf383.

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LeBrun, Alexander, Ronghui Ma, and Liang Zhu. "Tumor Shrinkage Study in Magnetic Nanoparticle Hyperthermia Based on Designed Heating Protocols." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6559.

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Magnetic nanoparticle hyperthermia has attracted growing attentions recently due to its ability of confining nanoparticle-induced heating in targeted tumor region. Our recent studies have identified an injection strategy to achieve repeatable and controllable nanoparticle deposition patterns in PC3 tumors using microCT scans. Based on the injection strategy, simulation of temperature elevations in tumors is conducted to design heating protocols to induce irreversible thermal damage to the entire tumors. In this study, in vivo heating experiments are performed on PC3 tumors implanted on mice following the designed heating protocols. The tumors in the control group without heating triple their sizes over a period of eight weeks. The tumors in the heating groups are heated for either 25 minutes or 12 minutes, representing that the Arrhenius integral is equal to or larger than 4 or 1 in the entire tumors, respectively. The tumors in the heating group of 25 minutes disappear completely after the 3rd days, and the site maintains the disappearance for over eight weeks. The sizes of the tumors in the heating group of 12 minutes decrease in the first ten days, however, the tumors re-grow afterwards, and by the end of the 8th week, they are approximately 60% larger than their initial size. This study demonstrates the importance of imaging-based design for individualized treatment planning. The success of the designed heating protocol in complete damaging PC3 tumors validates the theoretical models used in planning the heating treatment in magnetic nanoparticle hyperthermia.
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Zanandrea, A., I. M. da Costa, S. L. G. Dutra, N. Trivedi, and A. L. Padilha. "Estudo de Micropulsacoes Geomagneticas PC3-5 em Baixas Latitudes, no Brasil." In 5th International Congress of the Brazilian Geophysical Society. European Association of Geoscientists & Engineers, 1997. http://dx.doi.org/10.3997/2214-4609-pdb.299.368.

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Hernandez, James R., Steven M. Mooney, Gonzalo Torga, James E. Verdone, and Kenneth J. Pienta. "Abstract 1394: CD44 isoform expression illuminates multiple CSC subpopulations in PC3." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1394.

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Yao, Xueling, Shuang He, Jingliang Chen, and Xiaoyun Lu. "Effects of low-intensity nanosecond pulsed electromagnetic field on PC3 cells." In 2013 IEEE Conference on Electrical Insulation and Dielectric Phenomena - (CEIDP 2013). IEEE, 2013. http://dx.doi.org/10.1109/ceidp.2013.6748136.

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Liu, Y. H., F. W. Menk, and B. J. Fraser. "Pc3-4 ULF waves observed by Cluster prenoon in outer magnetosphere." In 2014 XXXIth URSI General Assembly and Scientific Symposium (URSI GASS). IEEE, 2014. http://dx.doi.org/10.1109/ursigass.2014.6929552.

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Reports on the topic "PC3"

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OCOMA, E. C. Seismic Adequacy Review of PC012 SCEs that are Potential Seismic Hazards with PC3 SCEs at Cold Vacuum Dryer (CVD) Facility. Office of Scientific and Technical Information (OSTI), August 1999. http://dx.doi.org/10.2172/797683.

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Farrel, A. PCC-PCE Communication and PCE Discovery Requirements for Inter-Layer Traffic Engineering. Edited by T. Takeda. RFC Editor, December 2011. http://dx.doi.org/10.17487/rfc6457.

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Yang, Annie. Role of the p53 Tumor Suppressor Homolog, p63, in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada437662.

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Yang, Annie. Role of the p53 Tumor Suppressor Homolog, p63, in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2006. http://dx.doi.org/10.21236/ada456200.

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Yang, Annie. Role of the p53 Tumor Suppressor Homolog, p63, in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2007. http://dx.doi.org/10.21236/ada471497.

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Simms, D. A., and C. P. Butterfield. PC-based PCM (Pulse Code Modulation) telemetry data reduction system hardware. Office of Scientific and Technical Information (OSTI), February 1990. http://dx.doi.org/10.2172/7024568.

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Yasukawa, S., and A. Farrel. Path Computation Clients (PCC) - Path Computation Element (PCE) Requirements for Point-to-Multipoint MPLS-TE. RFC Editor, June 2010. http://dx.doi.org/10.17487/rfc5862.

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Wang, Bin, and Stephen J. Elledge. Involvement of 53BP1, a p43 Binding Protein, in Chk2 Phosphorylation of p53 and DNA Damage Cell Cycle Checkpoints. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada417278.

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Gardner, S., D. Clague, J. Vandersall, G. Hon, and P. Williams. Virtual PCR. Office of Scientific and Technical Information (OSTI), February 2006. http://dx.doi.org/10.2172/894750.

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Chefetz, Benny, and Jon Chorover. Sorption and Mobility of Pharmaceutical Compounds in Soils Irrigated with Treated Wastewater. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7592117.bard.

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Abstract:
Research into the fate of pharmaceutical compounds (PCs) in the environment has focused on aspects of removal efficiency during sewage treatment, degradation in surface water and accumulation in soils and sediments. However, very little information is available on the binding interactions of pharmaceuticals with dissolved organic matter (DOM) originating from wastewater treatment. Such interactions can significantly affect the transport potential of PCs in soils by altering compound affinity for soil particle surfaces. Our primary hypothesis is that the transport potential of PCs in soils is strongly impacted by the type and strength of interaction with DOM and the stability of resulting DOM-PC complexes. The overarching goal of the proposed work is to develop a better understanding of the risk associated with introduction of PCs into the environment with treated wastewater. This goal has been achieved by elucidating the mechanisms of the interaction of selected pharmaceuticals (that have shown to be widespread wastewater contaminants) with DOM constituents; by determining the stability and fate of DOM-PC complexes introduced to soils and soil constituents; and by evaluating the potential uptake of these compounds by plants. Based on the results obtained in this study (column and batch sorption-desorption experiments), we suggest that PCs can be classified as slow-mobile compounds in SOM-rich soil layers. When these compounds pass this layer and/or are introduced into SOM-poor soils, their mobility increases significantly. Our data suggest that in semiarid soils (consisting of low SOM), PCs can potentially be transported to the groundwater in fields irrigated with reclaimed wastewater. Moreover, the higher mobility of the acid PCs (i.e., naproxen and diclofenac) in freshwater column systems suggests that their residues in soils irrigated with reclaimed wastewater can leach from the root zone and be transported to the groundwater after rain events. Our data obtained from the binding experiments of PCs with DOM demonstrate that the hydrophobic DOM fractions were more efficient at sorbing PCs than the more polar hydrophilic fractions at a pH near the pKa of the analytes. At the pH of natural semiarid water and soil systems, including that of reclaimed wastewater and biosolids, the role of the hydrophobic fractions as sorption domains is less important than the contribution of the hydrophilic fractions. We also hypothesize that the DOM fractions interact with each other at the molecular level and do not act as independent sorption domains. In summary, our data collected in the BARD project demonstrate that the sorption abilities of the DOM fractions can also significantly affect the mobility of pharmaceutical compounds in soils influenced by intensive irrigation with treated wastewater or amended with biosolids.
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