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1
Ellis, Cameron B. "Tribopairs in Wellbore Drilling: A Study of PCD Tilting Pad Bearings in an Electric Submersible Pump." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7233.
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A polycrystalline diamond was tested as a bearing material for a tilting pad thrust bearing to be used in an electric submersible pump, which elevates process fluids from the bottom of well bores. The goal of this study was to compare the PCD to a current best of technology, which is stainless steel with an engineering polymer.This study found that PCD can handle larger loads than current technology but is limited in size due to diamond sintering and manufacturing constraints. The maximum size is Ø75mm.
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Shah, Syed Mohammad Ali. "The optimisation of PCD bit performance in coal measure rocks." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385944.
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Bian, Shuning. "Real-time monitoring of ultrasound and cavitation mediated drug delivery." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e5a774a9-5b93-4862-8dd9-0614d234ff28.
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Drug delivery plays a crucial role in the chemotherapeutic treatment of cancerous solid tumours. A drug, no matter how potent, is only truly effective when it can be delivered to all targeted cells. In recent years it has been recognised that the poor response of tumours to chemotherapy is in part due to inadequate drug delivery. Numerous strategies have been developed to overcome this issue. Of particular interest to the present work is the application of ultrasound and cavitation, which has been shown to be capable of enhancing drug delivery in solid tumours. These enhancements are attributed to the acoustic cavitation of microbubbles and the effects cavitation induces in the surrounding tissue. To better understand how ultrasound and cavitation can enhance drug delivery, an instrument was developed that is capable of monitoring in real-time and in-situ the effect of ultrasound and cavitation on drugs and drug analogues within flow channel models. The developed instrument was used to investigate the effect of ultrasound and cavitation on drug-eluting beads used for chemoembolisation, the effects of drug loading on microbubble dynamics, the effects produced by different cavitation agents, and the performance of passive acoustic mapping as a means of cavitation monitoring. The findings of the above investigations include: more physiologically relevant characterisations of drug-eluting beads pharmacokinetics, the possibility of significant changes in microbubble dynamics due to drug loading, a lack of general correlation between detected cavitation activity and induced effects, and the potential of passive acoustic mapping for monitoring cavitation and ultrasound induced effects. These and other findings also demonstrate the utility of the developed instrument for studying the many facets and applications of ultrasound and cavitation mediated drug delivery.
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Trčka, Tomáš. "Analýza silového zatížení stopkových fréz s PCD s ohledem na jejich ostření." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318670.
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Measurement of the force loading is a significant type of measurement in mechanical engineering applied to analyse important aspects in the machining process. In addition to the determination of specific material constants, it is possible to analyse, for example, various machining strategies, geometries of tools or the degree of wear of the cutting edges of cutting tools. This master’s thesis deals especially with the last two mentioned aspects which are subjects of an experiment on end mills with PCD inserts sharpened by a different technology. In the introductory part the cutting forces are theoretically analysed along with their measurement possibilities and the technology of the production of the mills including their sharpening – WEDM and EDM-G. One chapter is concerned with the milling of plastic materials, as PVC was the material used for the workpiece during the experiment. The first experimental part is devoted to the analysis of sharpened tools followed by the measurement of forces using the piezoelectric dynamometer and the subsequent analysis of the influence of the different tool geometry. The last conducted experiment monitors how the overall cutting forces of individual end mills sharpened by different technology changed over specific milling time slots.
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Marrone, Anna Filomena. "Retinoblastoma (Rb) regulation and programmed cell death (PCD) in dystrophic (mdx) skeletal muscle." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621356.
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Ben, hamed Ibtissem. "Réponses cellulaires rapides de l’halophyte Cakile maritima au choc salin : analyse de leur implication dans la mort cellulaire programmée et l’adaptation." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS444.
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Les travaux présentés dans cette thèse ont porté sur la specificité des réponses cellulaires de l’halophyte obligatoire Cakile maritima au choc salin et la régulation des événements précoces impliqués dans la mort cellulaire programmée et la survie en condition de salinité. Dans une première étape, nous avons montré que cette plante est aussi tolérante aux chocs salins répétés qu’au stress salin progressif. Cependant, on a observé de zones de mort cellulaires sur les feuilles âgées soumises à un choc salin sévère (400 mM NaCl). Pour mieux cerner la cascade d’événements impliqués dans ce processus de mort cellulaire, nous avons poursuivi nos expériences sur des suspensions cellulaires de C. maritima, dont nous avons-nous même optimisé les conditions d’obtention, et des suspensions cellulaires d’Arabidopsis thaliana (glycophyte modèle). Chez les deux espèces, nous avons observé une mort cellulaire programmée qui dépend de la durée et l’intensité du traitement salin appliqué, et qui met en jeu les mêmes événements cellulaires notamment la dépolarisation de la membrane plasmique due à l’entrée de Na+ par les NSCCs, un dysfonctionnement mitochondrial, une production d’anions superoxydes et une activation de protéines de type caspase. La tolérance de C. maritima au stress salin serait potentiellement due à une forte accumulation d’ascorbate qui permettrait à cette halophyte de mieux réduire les dommages générés par le stress oxydatif. C. maritima s’est aussi distinguée par une meilleure capacité de contrôler l’accumulation cytoplasmique de Na+, conduisant à la survie de ses cellules en condition de salinité. Cette étude sur la mort cellulaire induite par le NaCl chez les cellules en culture de C. maritima nous a aussi permis de mettre en évidence deux types de comportement dans cette population de cellules en culture : l’un lié à une dépolarisation soutenue en réponse au NaCl conduisant probablement à la mort de ces cellules, l’autre lié à une dépolarisation transitoire indiquant que l’influx de Na+ au travers des NSCC était régulé permettant probablement aux cellules présentant ce comportement de survivre en évitant l'accumulation excessive de Na+ dans le cytosol. Dans la dernière partie de ce travail, nous avons mis en évidence la capacité de C. maritima d’exclure Na+ via le système SOS. Ce résultat suggère l’existence d’une deuxième voie de signalisation induite parallèlement à celle conduisant à la mort cellulaire. Cette voie, impliquant une production rapide d’oxygène singulet, pourrait permettre un influx de Ca2+ dans le cytoplasme activant la protéine SOS3 et en cascade SOS2 et SOS1 et les H+-ATPases de la membrane plasmique permettant un efflux du Na+ via SOS1 hors des cellulesAbstractThis work aimed at understanding the specificity of cellular responses of the obligate halophyte Cakile maritima to salt shock and regulation of early events involved in programmed cell death and survival under salinity conditions. In a first step, we have shown that this plant is tolerant upon both repetitive salt shocks and gradual salt application. However, we have observed a cell death zones on older leaves subjected to a severe shock saline (400 mM NaCl). To better understand the cascade of events involved in the cell death process, we continued our experiments on suspension culture of C. maritima, which we have optimized ourselves the conditions for establishment and suspension culture of Arabidopsis thaliana (glycophyte model). In both species, salinity induced programmed cell death that depends on the duration and the intensity of the applied salt treatment. Also, the same cellular events, including depolarization of the plasma membrane due to the Na+ influx by NSCCs, mitochondrial dysfunction, production of superoxide anions and activation of caspase-like proteins, occurs early in response to salt stress. C. maritima tolerance to salt stress is potentially due to a strong accumulation of ascorbate that would allow this halophyte to better reduce damage generated by oxidative stress. C. maritima is also distinguished by a better ability to control the cytoplasmic accumulation of Na+, leading to the survival of its cells under salinity conditions. This study on cell death induced by NaCl in cell culture of C. maritima also allowed us to identify two types of behavior in this population of cells in culture: one related to a sustained depolarization in response to NaCl probably leading to death of these cells, the other linked to a transient depolarization indicating that the Na+ influx through the NSCC was probably regulated allowing cells exhibiting this behavior to survive by avoiding excessive accumulation of Na+ in the cytosol. In the last part of this work, we have demonstrated the ability of C. maritima to exclude Na+ via the SOS system. This result suggests the existence of a second signaling pathway induced in parallel to that leading to cell death. This pathway, involving a rapid production of singlet oxygen, could allow a Ca2+ influx in the cytoplasm that acts as an elicitor for activation of SOS3 protein and SOS2-SOS1 cascade and H+- ATPases of the plasma membrane allowing Na+ efflux via SOS1 out of cells
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Siddique, Abu Bakar. "Exploring the possibility of a people centred development (PCD) process in Rajoir Thana in Bangladesh." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314250.
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Chittaranjan, Suganthi. "A functional genomics approach identifies novel genes involved in steroid-hormove induced programmed cell death in Drosophila." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2725.
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Programmed Cell death (PCD) is a highly conserved and genetically controlled event
that plays important roles in animal development, homeostasis and disease. Our first
objective was to discover and characterize new genes involved in PCD. Since many PCD
genes are conserved in Drosophila, and steroid-induced PCD of larval salivary glands
(SGs) is transcriptionally regulated with features of both apoptosis and autophagy, we
used this exceptionally well-suited in vivo system and performed Serial Analysis of Gene
Expression (SAGE) in three pre-death stages. SAGE identified 1244 expressed
transcripts, including genes involved in autophagy, apoptosis, immunity, cytoskeleton
remodeling, and proteolysis. Of the 1244 transcripts, 463 transcripts belonged to
knownlpredicted genes and were 5-fold differentially expressed prior to cell death.
Next, we investigated the role of differentially expressed genes from SAGE, in cell
death or cell survival, by RNA interference (RNAi ) in l(2)mbn haemocyte Drosophila
cells. l(2)mbn cells undergo morphological changes in response to ecdysone treatment,
and ultimately undergo PCD. We used cell viability, cell morphology, and apoptosis
assays to identify the death-related genes and determined their ecdysone dependency and
function in cell death regulation. Our RNAi screen identified six new pro-death related
genes, including SH3PXJ and Soxl4, and 21 new pro-survival genes including SoxN.
Identification of Soxl4 as pro-death and SoxN as pro-survival suggests that these Sox
box proteins may have opposing roles in ecdysone-mediated cell death.
Our final objective was to elucidate the function of CG409], a Drosophila
homologue of human TNF-alpha induced proteins 8 (TNFAIP8) we identified from
SAGE. We created loss-of-function and overexpression mutants of CG4091 to study
gene function in vivo and employed immunoprecipitation and mass-spectrometry assays
to identify proteins interacting with CG409] in vitro. We identified two proteins that are
involved in n-fatty acid oxidation and several cytoskeletal proteins as interaction
partners. Immunofluorescence based assays in vivo and in vitro revealed that CG409] is
necessary for cytoskeletal remodeling. Further, defects in CG4091 expression affect
cellular functions such as autophagy and lipid metabolism/trafficking that require an
intact cytoskeleton. Together, our studies provided new insights into the molecular
mechanisms involved in Drosophila SG cell death.
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Moore, Daniel John. "Identification and characterisation of conserved ciliary genes expressed in Drosophila sensory neurons." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17918.
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Drosophila provide an excellent model organism in which to study cilia as there are only two ciliated cell types; the sensory neurons and sperm cells. The chordotonal neuron is one such ciliated cell and is required for hearing, proprioception and gravitaxis. Mechanical manipulation of the cilium that extends from the neuronal dendrite is required for signal transduction. Chordotonal neuronal differentiation is regulated by a transcription factor cascade. Atonal begins the cascade, which is then continued by RFX and Fd3F for ciliary genes (Cachero et al 2011, Newton et al 2012). Genes expressed in developing chordotonal neurons are downstream of these transcription factors and their characterisation can further elucidate how neuronal differentiation is regulated. Ciliary genes are highly enriched in developing chordotonal cells; uncharacterised genes enriched in these cells can therefore be considered candidate ciliary genes (Cachero et al 2011). A behavioural assay was conducted to identify further genes that could have a role in ciliary formation and function. Candidate genes were identified by combining enrichment data with previous genomic, proteomic and transcriptomic studies of cilia. A climbing assay of RNAi mediated knock down of these genes identified a number of candidates for future work. One gene found to be highly enriched in developing chordotonal neurons is CG11253. CG11253EY10866 P element insertion mutant flies show a mild uncoordinated phenotype in a climbing assay consistent with reduced chordotonal organ function. Male flies are also infertile due to a lack of motile sperm. CG11253 is expressed in motile ciliated cells and is conserved in organisms with motile cilia. CG11253 expression is also regulated by RFX and Fd3F, suggesting that it is involved in cilium motility. This was confirmed by electron microscopy, which showed disruption of axonemal dynein arm localisation in chordotonal cilia and sperm flagella. A CG11253::mVenus fusion protein was found to localise mainly to the cytoplasm and to a lesser extent the cilia of chordotonal neurons. Patients with symptoms consistent with Primary Ciliary Dyskinesia (PCD), a condition caused by cilium immotility, have subsequently been found to have point mutations in ZMYND10, the human homologue of CG11253. The identification of PCD patients with ZMYND10 mutations showed that investigating cilium motility in Drosophila chordotonal neurons could identify novel PCD genes. It was thought that investigating previously uncharacterised targets of Fd3F could identify novel genes involved in cilium motility and thus candidate PCD genes. CG31320 is a gene regulated by RFX and Fd3F and conserved in organisms with motile cilia. RNAi mediated knock down of CG31320 resulted in both a mild uncoordinated phenotype and male infertility due to a lack of motile sperm. Electron microscopy showed a complete loss of axonemal dynein arms in chordotonal neuron cilia. An mVenus fusion protein of CG6971, an inner dynein arm component, was also mislocalised from the cilia in CG3132027 deletion mutant larvae. This shows that CG31320 is required for the appropriate localisation of the axonemal dynein arms and thus cilium motility. This further showed that uncharacterised genes enriched in chordotonal neurons and regulated by Fd3F could be novel ciliary genes required for cilium motility. Our collaborators and Horani et al (2012) showed that the human homologue of CG31320 (HEATR2) is mutated in patients with PCD, further confirming that this method can be used to identify PCD genes. I have identified two factors required for cilium motility. Disruption of the axonemal dynein arms in both cases results in reduced coordination, and lack of fertility due to sperm immotility. Mutations in the human homologues of these genes have been found to result in PCD. This indicates that further PCD genes could be identified from genes enriched in Drosophila chordotonal neurons that are regulated by Fd3F.
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Young, Bennett. "Is the Arabidopsis peptide 'kiss of death' an inducer of programmed cell death?" Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/is-the-arabidopsis-peptide-kiss-of-death-an-inducer-of-programmed-cell-death(33ac50ec-bd4f-4069-8618-bcd21e520b23).html.
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Programmed Cell Death (PCD) is an essential process utilised for the defence and development of all multicellular organisms. In plants however, relatively little is known about the genes involved with the regulation and execution of this process. In particular, even less is known about the molecular components which act high up in the PCD pathway. In this thesis, we carried out an investigation into the novel peptide-encoding gene KISS OF DEATH (KOD). In Arabidopsis, KOD was found to be involved with mediating the elimination of the suspensor, an organ which undergoes developmental PCD. Two mutant alleles of KOD showed reduced PCD in both the suspensor and during heat-shock induced PCD of root hairs. Over-expression of KOD in plant tissues was sufficient to cause death in leaves or whole seedlings and involved the activation of caspase-like proteolytic activity. KOD-induced PCD was found to require light in leaves and is also sensitive to the PCD suppressor genes AtBI-1 and P35. We suggest that KOD acts high up in the PCD cascade as its expression resulted in depolarisation of the mitochondrial membrane, which is an early step in plant PCD. KOD appears to be a plant-specific peptide that is sufficient to induce PCD in Arabidopsis in the absence of external triggers. Typical BLAST searches yielded no obvious homolog for KOD, therefore a bioinformatics screen of the Arabidopsis genome was carried out. This screen for small genes similar in size to KOD enabled us to detect 10 previously unidentified genes, one of which may represent a putative KOD homolog. In summary, KOD appears to be a novel pro-PCD component of the Arabidopsis cell death machinery and represents the first plant peptide to be involved with a form of developmental PCD.
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Manthri, Sandeep. "EXPERIMENTAL INVESTIGATION OF PCD COMPACT CORE DRILL PERFORMANCE ON BASALT SIMULATING SUSTAINABLE DRY DRILLING ON MARS." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_theses/495.
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Missions to Mars aim to characterize rock and subsurface soil samples and possibly bring some back to Earth for more thorough and sophisticated examination. The Martian surface is covered with basalt which has high compressive strength (andamp;gt;130 MPa), and is more difficult to drill than the much softer sedimentary formations that are presently being drilled using diamond core drills. The main objective of this thesis work is to provide the requisite groundwork towards the development of improved and sustainable drills for subsurface drilling applications on Mars, when their goals are obtaining samples. Since progressive drill-wear is substantial in sustained drilling, the experiments were designed and conducted to study the tool-wear mechanisms and understand the associated effects on drilling performance in subsurface drilling of basalt. Core drilling experiments are conducted with different drill geometries and cutting conditions in a Martian simulant, basaltic rock; monitoring thrust force, torque and measuring tool-wear for a series of successive depth-increments. Based on the experimental results an optimization model has been developed for maximizing drilling depth with minimum tool-wear. This preliminary work will help the development of smart and sustainable drills for dry drilling applications for future NASA missions to Mars.
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Mattos, Fernanda Gomes. "Inserção das PCD beneficiárias do BPC no mercado de trabalho: O programa BPC trabalho em questão." Universidade Estadual da Paraíba, 2016. http://tede.bc.uepb.edu.br/jspui/handle/tede/2870.
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The work of people with disabilities (PCD) has been, historically, the struggle of the social movements of this segment under the discourse of social inclusion. We understand that the forms of response to the needs of the PCD are linked to the different models of corporate organization and that, in the capitalist mode of production, does not escape the logic of productivity and extraction of surpluses necessary for the accumulation of capital. In 2012, the BPC Work Program was created, which aims to promote access to professional qualification and the labor market for beneficiaries of the Benefict of Continuous Provision (BPC). The present dissertation aims to analyze the insertion in the labor market of disabled people, beneficiaries of BPC, through this Program. To do so, we undertake a theoretical approach in order to understand the economic and political ground in which the object is inserted, as well as to analyze issues specific to the PCD. We take as a historic mark the crisis of capital and the bourgeois responses to the resumption of growth, with direct implications in the world of labor under productive restructuring and social policies, considering also the current conjuncture of counterreforms. In the Brazilian particularity, we infer how the ideals of social-liberalism were impregnated in social policies, in particular in the politics of Social Assistance, during the period of the PT governments, being the Program in study aligned to such perspective. About people with disabilities, we approach the questions about their denomination and insertion in social relations in different societal contexts, as a preamble to comprehend the relationship of this segment with the world of work. The methodology adopted prioritized the bibliographic and documentary study, which took place in the sense of understanding the contradictions and mediations intrinsic to this object. From the critical-dialectical approach, through the Marxian categories, we seek to capture it from its appearance. Based on information from the Ministries of policies involved in the implementation of the Program (social assistance, education and labor), as well as from the National Institute of Social Security, we have taken a course that has allowed us to make important approaches to the Program. The contradictions that permeate social policies and current downward trends in the face of the offensive of neoliberal orthodoxy imply a great deal in the applicability of the Program and in what it means the beneficiaries of the BPC are considered capable of producing and then called to be inserted in the job market. Therefore, in discussing the autonomy of PCDs through work and stressing the relationship between social assistance and labor, the Program in question puts issues relevant to the demands of the PCD on the agenda and, at the same time, is functional to capital, in a peculiar way in times of crisis, because it ends up being a gateway to the BPC, when it stimulates them to enter the labor market, to become self-sufficient citizens, emancipated in appearance, with implications for the composition of relative overpopulation and lump-proletariat.
O trabalho das pessoas com deficiência (PCD) tem sido, historicamente, bandeira de luta dos movimentos sociais desse segmento sob o discurso da inclusão social. Compreendemos que as formas de resposta às necessidades das PCD estão vinculadas aos diferentes modelos de organização societária e que, no modo de produção capitalista, não foge à lógica de produtividade e extração de excedentes necessários à acumulação do capital. Em 2012, foi criado o Programa BPC Trabalho, o qual visa a promoção do acesso à qualificação profissional e ao mercado de trabalho aos beneficiários do benefício de prestação continuada (BPC). A presente dissertação tem como objetivo analisar a inserção no mercado de trabalho das pessoas com deficiência, beneficiárias do BPC, através desse Programa. Para tanto, empreendemos um caminho teórico em busca de compreender qual o solo econômico e político no qual está inserido o objeto, além de analisar questões específicas às PCD. Tomamos como marco a crise do capital e as respostas burguesas para retomada do crescimento, com implicações diretas no mundo do trabalho sob a reestruturação produtiva e para as políticas sociais, considerando ainda a conjuntura atual de contrarreformas. Na particularidade brasileira, inferimos como os ideais do social-liberalismo foram impregnados nas políticas sociais, em particular na política de Assistência Social, durante o período dos governos petistas, estando o Programa em estudo alinhado a tal perspectiva. Em relação às pessoas com deficiência, nos aproximarmos das questões sobre a sua denominação e inserção nas relações sociais nos diferentes contextos societários, como preâmbulo para compreendermos a relação desse segmento com o mundo do trabalho. A metodologia adotada priorizou o estudo bibliográfico e documental, que se deu no sentido de entender as contradições e mediações intrínsecas ao objeto. A partir da abordagem crítico-dialética, mediante as categorias marxianas, buscamos capturá-lo partindo de sua aparência. Tendo como fontes informações dos Ministérios das políticas envolvidas na execução do Programa (assistência social, educação e trabalho), bem como do Instituto Nacional de Seguro Social, trilhamos um percurso que nos permitiu aproximações importantes a respeito do Programa. As contradições que perpassam as políticas sociais e as tendências de retrocesso na atualidade, frente à ofensiva da ortodoxia neoliberal, implicam sobremaneira na aplicabilidade do Programa e no que significa os beneficiários do BPC serem considerados capazes de produzir e, então, chamados a se inserir no mercado de trabalho. Portanto, o Programa em questão, ao pôr em debate a discussão sobre autonomia das PCD através do trabalho e ao tensionar a relação entre Assistência Social e trabalho, põe na ordem do dia questões pertinentes às demandas das PCD e, concomitantemente, é funcional ao capital, de forma peculiar em tempos de crise, pois acaba sendo uma porta de saída do BPC, quando estimula que esses se insiram no mercado de trabalho, que se tornem cidadãos autossuficientes, na aparência emancipados, com implicações na composição da superpopulação relativa e lumpemproletariado.
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Silva, Cristiano Alves da. "Evaluation of the accuracy of orthomosaics and terrain digital models generated by the UAV and its application in calculating the volume of Cariri Stone piles." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14594.
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Departamento Nacional de ProduÃÃo MineralNos Ãltimos anos foi exponencial o avanÃo tecnolÃgico dos denominados VeÃculos AÃreos NÃo Tripulados (VANT) Estes equipamentos sÃo capazes de gerar produtos de sensoriamento remoto de elevada acurÃcia com baixo custo operacional desempenhando atividades antes executadas exclusivamente por aeronaves tripuladas Neste contexto o Departamento Nacional de ProduÃÃo Mineral (DNPM) para maximizar suas aÃÃes de fiscalizaÃÃo e gestÃo da mineraÃÃo firmou parceria com a Universidade de BrasÃlia (UnB) para desenvolvimento de um VANT de pequenas dimensÃes capaz de gerar ortomosaicos e Modelos Digitais do Terreno (MDT) de alta acurÃcia Para alcanÃar esse objetivo a UnB desenvolveu uma aeronave de 25 kg equipada com uma cÃmera nÃo mÃtrica capaz de obter fotografias de alta resoluÃÃo que apÃs processadas utilizando o mÃtodo de correlaÃÃo de imagens sobrepostas gera uma nuvem de pontos das coordenadas tridimensionais da superfÃcie permitindo a geraÃÃo de ortomosaicos e MDTs Contudo a tecnologia VANT ainda à considerada emergente SÃo comuns indagaÃÃes sobre o mÃtodo de levantamento o sensor utilizado e principalmente a acurÃcia dos resultados obtidos fato que motivou a elaboraÃÃo deste estudo de caso O objetivo principal desta pesquisa foi realizar a avaliaÃÃo da acurÃcia dos ortomosaicos e MDTs gerados a partir dos dados coletados pelo VANT desenvolvido pela UnB bem como sua aplicaÃÃo no cÃlculo do volume de pilhas de rejeito do calcÃrio sedimentar laminado da Bacia do Araripe no Cearà comercializado com o nome de Pedra Cariri sendo comparada sua acurÃcia com as obtidas pelas tecnologias Global Navigation Satellite System (GNSS) e Light Detecting and Ranging (LIDAR) mais utilizadas pelo seguimento da mineraÃÃo para esta finalidade Para avaliaÃÃo da acurÃcia foi usado o mÃtodo de testes de hipÃteses a partir da anÃlise de tendÃncia e precisÃo sendo os resultados classificados de acordo com o PadrÃo de ExatidÃo CartogrÃfica dos Produtos CartogrÃficos Digitais (PEC-PCD) ApÃs os experimentos realizados foi possÃvel constatar que o VANT-UnB/DNPM à capaz de gerar ortomosaicos e MDTs de alta acurÃcia compatÃveis com os obtidos por aerofotogrametria convencional desde que devidamente orientado por pontos de apoio de solo apresentando melhor acurÃcia no cÃlculo de volume neste estudo de caso se comparado com a modelagem realizada com as tecnologias GNSS e LIDAR
Recently, the technological advancement of Unmanned Aerial Vehicles (UAVs) has been exponential. This equipment are capable of generating remote sensing products of high accuracy at low operating costs, carrying out activities previously performed exclusively by manned aircraft. In this context, the National Department of Mineral Production (DNPM), aiming to maximize their actions of oversight and management of mining, has partnered with the University of Brasilia (UnB) for the development of a small UAV capable of generating orthomosaics and Terrain Digital models (TDM) with high accuracy. To achieve such objective, UnB has developed a 2,5 kg aircraft equipped with a small-format camera, nonmetric, capable of obtaining high-resolution photographs, after being processed through method of computing similarities between overlapping images, generates a cloud of points of the three-dimensional coordinates (x, y, z) of the surface, allowing to generate orthomosaics and TDMs. However, UAV technology is still considered emerging, being common questions about the survey method, used sensor and mainly accuracy of obtained results, a fact that motivated the elaboration in this case study. The main purpose this research is to evaluate of the accuracy of orthomosaics and TDMs generated from the data collected by the UAV developed by UnB, as well it's application in calculating the volume of laminate sedimentary limestone tailings piles of Araripe Basin in CearÃ, extracted in the form of tiles in natura marked under the name of Cariri Stone, compared it's accuracy with the results obtained with Global Navigation Satellite System (GNSS) and Light Detecting and Ranging (LIDAR) technologies, more commonly used by mining for this purpose. To evaluating the accuracy was used hypothesis testing method, from the trend and precision of analysis, and the results classified according to the Standard Cartographic Accuracy of Digital Cartographic Products (PEC-PCD). After the experiments performed, it was possible to acknowledge that the UAVUnB/DNPM is capable of generating with accuracy orthomosaics and MDTs, consistent with those obtained by conventional aerial photography, if properly oriented by ground control points. In this case study, the UAV showed better results when compared with modeling performed through GNSS and LIDAR technologies.
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Liadis, Nicole. "The role of caspase-3 in regulating neurotrophic and NMDA-dependent PCD in the mammalian CNS in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63101.pdf.
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Abreu, Mauricio de Carvalho. "O problema da criação e consolidação de conhecimento na Philips Components Display - PCD: unidade São José dos Campos." reponame:Repositório Institucional do FGV, 2001. http://hdl.handle.net/10438/5863.
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Previous issue date: 2001-06-27T00:00:00ZAnalisa o modelo de criação de conhecimento da Philips Components Display e confronta-o com um modelo teórico. Aborda as diferenças culturais na aplicação do modelo teórico e que impactos essas diferenças representas na aplicalidade desse modelo na cultura da PCD e brasileira
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Dutra, Renata Dias. "Olhos que tocam o chão, corpos na contramão: PCD, acessibilidade e mobilidade no centro histórico da cidade de Goiás." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/9259.
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Made available in DSpace on 2019-01-29T09:45:35Z (GMT). No. of bitstreams: 2 Dissertação - Renata Dias Dutra - 2018.pdf: 2180716 bytes, checksum: eaf143b8110c564444d280110b46d697 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-10-02
Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
This master's research aimed to analyze the accessibility and mobility of public spaces located in the historical center of the city of Goiás-GO, in relation to the use of spaces and places by the person with physical disability. The city of Goiás presents itself as a historical patrimony of Humanity and has built its architectural, historical and cultural appearance with the profile of a mining city, with Catholic religious predominance and buildings marked by slavery. The city that was once the capital of the state, grew in an unplanned urbanistic way, the historic center was maintained where monuments and buildings can be traced back to the beginning of the history of the state, however its buildings that have undergone several reforms do not count with restorations / adaptations in favor of accessibility, making it difficult for physically handicapped visitors and residents of the city itself. Many of its residents who have some kind of physical disability had little access to the culture and leisure provided by their museums, churches and other spaces as a result of stones, staircases and non-standard accessibility ramps. The barriers that the historic center generates go beyond the difficulty of access caused by physical barriers due to the difficulty of accessing their spaces, but the generation of attitudinal barriers and diverse constraints that affect them and makes them try to avoid certain routes and not be able to enjoy parties traditional, even religious, among others. With the present research it was possible to note that Goiás 12 is a city that presents a high rate of accessibility and mobility unfeasibility, which ends up compromising not only people with physical disability or reduced mobility, but also the entire population, since investments could intensify tourism and therefore income in the city. We have worked with the idea that capitalism intertwines the most varied areas of human experience, where the commodified body suffers interference from space in the same way that it has become a biopower space and this biopower interferes in spaces. Taking the considerations that urban planning and reorganization measures need to be made and carried out so that the historic center and the city as a whole can receive the entire public in an egalitarian way, accessibility is not understood here as the only way to improve conditions of the lives of people with physical disabilities, but without a doubt it is a beginning towards equity, destroying the walls of prejudice and exclusion, overcoming the invisible barriers between normal sayings and people with any physical disabilities.
Esta pesquisa de mestrado teve finalidade analisar a acessibilidade e mobilidade dos espaços públicos localizados no centro histórico da cidade de Goiás- GO, em relação ao uso dos espaços e lugares pela pessoa com deficiência física. A cidade de Goiás apresenta como patrimônio histórico da Humanidade e construiu sua aparência arquitetônica, histórica e cultural com o perfil de cidade de mineração, predomínio religioso católico e construções marcadas pela escravidão. A cidade que outrora fora capital do estado, cresceu de forma não planejada urbanisticamente falando, foi mantido o centro histórico onde encontram-se monumentos e prédios que remontam o inicio da história do estado. No entanto, seus prédios que já passaram por diversas reformas, não contam com restaurações/adequações em prol da acessibilidade, tornando difícil o acesso para pessoas com deficiência física, tanto turistas, quanto residentes da própria cidade. Muitos de seus moradores que possuem algum tipo de deficiência física tiveram pouco acesso à cultura e lazer propiciado por seus museus, igrejas e outros espaços em decorrência das pedras, escadarias e rampas fora do padrão de acessibilidade. As barreiras que o centro histórico gera vão além da dificuldade de acesso ocasionada por barreiras físicas em decorrência da dificuldade de acessar seus espaços, mas da geração de barreiras atitudinais e constrangimentos diversos que afetam e os faz tentar evitar determinados percursos e não poderem desfrutar de festas tradicionais, até mesmo de cunho religioso entre outras. Com a presente pesquisa foi possível notar que Goiás é uma cidade que apresenta alto índice de inviabilidade de acessibilidade e de mobilidade, o que acaba por comprometer não apenas as pessoas que possuem deficiência física ou mobilidade reduzida, mas também toda a população, visto que investimentos de acessibilidade poderia intensificar o turismo e portanto a renda na cidade. As barreiras que o centro histórico gera vão além da dificuldade de acesso ocasionada por limites físicos em decorrência da complexidade transitável em seus espaços, mas da geração de barreiras atitudinais e constrangimentos diversos que afetam e os faz tentar evitar determinados percursos e não poderem desfrutar de festas tradicionais, até mesmo de cunho religioso entre outras. Trabalhou-se com ideia de que o capitalismo se entrelaça as mais variadas áreas da vivência humana, cujo corpo mercadorizado sofre interferências do espaço da mesma 11 forma que se tornou um espaço de biopoder e esse biopoder interfere nos espaços. Levando as considerações de que medidas de planejamento e reorganização urbana necessitam serem feitas e efetivadas para que assim o centro histórico e a cidade como um todo possa receber todo o público de forma igualitária, acessibilizar não é compreendido aqui como a única forma de melhorar as condições de vida das pessoas com deficiência física, mas sem dúvidas é um começo rumo à equidade, destruindo os muros do preconceito e da exclusão, derrubando ainda as barreiras invisíveis entre os ditos normais e as pessoas com possuem quaisquer deficiências físicas.
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Wijayanto, Teguh. "Genetic manipulation of programmed cell death (PCD) for reduced susceptibility to necrotrophic fungi in narrow-leafed lupin (Lupinus angustifolius) /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0206.
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CHEN, Yiqing. "POLISHING OF POLYCRYSTALLINE DIAMOND COMPOSITES." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/3682.
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This thesis aims to establish a sound scientific methodology for the effective and efficient polishing of thermally stable PCD composites (consisting of diamond and SiC) for cutting tools applications. The surface roughness of industrial PCD cutting tools, 0.06 μm Ra is currently achieved by mechanical polishing which is time consuming and costly because it takes about three hours to polish a 12.7 mm diameter PCD surface. An alternative technique, dynamic friction polishing (DFP) which utilizes the thermo-chemical reactions between the PCD surfaces and a catalytic metal disk rotating at high peripheral speed has been comprehensively investigated for highly efficient abrasive-free polishing of PCD composites. A special polishing machine was designed and manufactured in-house to carry out the DFP of PCD composites efficiently and in a controllable manner according to the requirements of DFP. The PCD polishing process and material removal mechanism were comprehensively investigated by using a combination of the various characterization techniques: optical microscopy, SEM and EDX, AFM, XRD, Raman spectroscopy, TEM, STEM and EELS, etc. A theoretical model was developed to predict temperature rise at the interface of the polishing disk and PCD asperities. On-line temperature measurements were carried out to determine subsurface temperatures for a range of polishing conditions. A method was also developed to extrapolate these measured temperatures to the PCD surface, which were compared with the theoretical results. The material removal mechanism was further explored by theoretical study of the interface reactions under these polishing conditions, with particular emphasis on temperature, contact with catalytic metals and polishing environment. Based on the experimental results and theoretical analyses, the material removal mechanism of dynamic friction polishing can be described as follows: conversion of diamond into non-diamond carbon takes place due to the frictional heating and the interaction of diamond with catalyst metal disk; then a part of the transformed material is detached from the PCD surface as it is weakly bonded; another part of the non-diamond carbon oxidizes and escapes as CO or CO2 gas and the rest diffuses into the metal disk. Meanwhile, another component of PCD, SiC also chemically reacted and transformed to amorphous silicon oxide/carbide, which is then mechanically or chemically removed. Finally an attempt was made to optimise the polishing process by investigating the effect of polishing parameters on material removal rate, surface characteristics and cracking /fracture of PCD to achieve the surface roughness requirement. It was found that combining dynamic friction polishing and mechanical abrasive polishing, a very high polishing rate and good quality surface could be obtained. The final surface roughness could be reduced to 50 nm Ra for two types of PCD specimens considered from pre-polishing value of 0.7 or 1.5 μm Ra. The polishing time required was 18 minutes, a ten fold reduction compared with the mechanical abrasive polishing currently used in industry.
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CHEN, Yiqing. "POLISHING OF POLYCRYSTALLINE DIAMOND COMPOSITES." University of Sydney, 2007. http://hdl.handle.net/2123/3682.
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Doctor of Philosophy (PhD)This thesis aims to establish a sound scientific methodology for the effective and efficient polishing of thermally stable PCD composites (consisting of diamond and SiC) for cutting tools applications. The surface roughness of industrial PCD cutting tools, 0.06 μm Ra is currently achieved by mechanical polishing which is time consuming and costly because it takes about three hours to polish a 12.7 mm diameter PCD surface. An alternative technique, dynamic friction polishing (DFP) which utilizes the thermo-chemical reactions between the PCD surfaces and a catalytic metal disk rotating at high peripheral speed has been comprehensively investigated for highly efficient abrasive-free polishing of PCD composites. A special polishing machine was designed and manufactured in-house to carry out the DFP of PCD composites efficiently and in a controllable manner according to the requirements of DFP. The PCD polishing process and material removal mechanism were comprehensively investigated by using a combination of the various characterization techniques: optical microscopy, SEM and EDX, AFM, XRD, Raman spectroscopy, TEM, STEM and EELS, etc. A theoretical model was developed to predict temperature rise at the interface of the polishing disk and PCD asperities. On-line temperature measurements were carried out to determine subsurface temperatures for a range of polishing conditions. A method was also developed to extrapolate these measured temperatures to the PCD surface, which were compared with the theoretical results. The material removal mechanism was further explored by theoretical study of the interface reactions under these polishing conditions, with particular emphasis on temperature, contact with catalytic metals and polishing environment. Based on the experimental results and theoretical analyses, the material removal mechanism of dynamic friction polishing can be described as follows: conversion of diamond into non-diamond carbon takes place due to the frictional heating and the interaction of diamond with catalyst metal disk; then a part of the transformed material is detached from the PCD surface as it is weakly bonded; another part of the non-diamond carbon oxidizes and escapes as CO or CO2 gas and the rest diffuses into the metal disk. Meanwhile, another component of PCD, SiC also chemically reacted and transformed to amorphous silicon oxide/carbide, which is then mechanically or chemically removed. Finally an attempt was made to optimise the polishing process by investigating the effect of polishing parameters on material removal rate, surface characteristics and cracking /fracture of PCD to achieve the surface roughness requirement. It was found that combining dynamic friction polishing and mechanical abrasive polishing, a very high polishing rate and good quality surface could be obtained. The final surface roughness could be reduced to 50 nm Ra for two types of PCD specimens considered from pre-polishing value of 0.7 or 1.5 μm Ra. The polishing time required was 18 minutes, a ten fold reduction compared with the mechanical abrasive polishing currently used in industry.
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Rojas, Dondero Carolina. "Programa de comunicación visual : para el posicionamiento de la calidad de contacto de las PcD fisicamotora en entorno urbano propio." Tesis, Universidad de Chile, 2006. http://repositorio.uchile.cl/handle/2250/100976.
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Generar presencia de las PcD físico-motoras, como individuos participantes de la sociedad, mediante un Programa de Comunicación visual orientado a posicionar la imagen y problemática de la PcD física motora, enfrentadas a la calidad de su contacto cotidiano en su entorno; físico, urbano y propio. Rompiendo la invisibilidad que rodea a estas personas; motivando, interesando y sensibilizando al ciudadano urbano para la adaptación de las PcD físico-motoras
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Garcia-Lorenzo, Maribel. "The Role of Proteases in Plant Development." Doctoral thesis, Umeå universitet, Kemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1386.
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Proteases play key roles in plants, maintaining strict protein quality control and degrading specific sets of proteins in response to diverse environmental and developmental stimuli. Similarities and differences between the proteases expressed in different species may give valuable insights into their physiological roles and evolution. Systematic comparative analysis of the available sequenced genomes of two model organisms led to the identification of an increasing number of protease genes, giving insights about protein sequences that are conserved in the different species, and thus are likely to have common functions in them and the acquisition of new genes, elucidate issues concerning non-functionalization, neofunctionalization and subfunctionalization. The involvement of proteases in senescence and PCD was investigated. While PCD in woody tissues shows the importance of vacuole proteases in the process, the senescence in leaves demonstrate to be a slower and more ordered mechanism starting in the chloroplast where the proteases there localized become important. The light-harvesting complex of Photosystem II is very susceptible to protease attack during leaf senescence. We were able to show that a metallo-protease belonging to the FtsH family is involved on the process in vitro. Arabidopsis knockout mutants confirmed the function of FtsH6 in vivo.
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Elghamoudi, Deblej. "Objective cough monitoring in children." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/objective-cough-monitoring-in-children(e3d822f0-d1b1-4056-8f98-1b6dd634c47f).html.
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Background: Cough is extremely common in childhood and a tool to objectively measure cough frequency would be clinically beneficial. To date paediatric cough monitoring systems have relied on manual cough counting which is time consuming and costly. The VitaloJAK⢠(Vitalograph, UK) is a custom built 24hr semi-automated cough monitoring device that has been used successfully to quantify cough in adults. This thesis consists of a series of studies using the VitaloJAK⢠monitor system in children. Methods: Firstly, we tested the feasibility of using the VitaloJAK⢠for 24 hr cough recordings in children and tested existing compression software for cough quantification. The VitaloJAK⢠system was then used to to assess and compare the cough frequency, variation and circadian distribution of cough in children with asthma, CF, and PCD during stable periods of disease and during an exacerbation. Finally, we used modelling to assess whether cough events are random events, or are clustered in time; the time intervals between coughs for each patient were calculated and fitted to an exponential model of random recurrences and a Weibull model for clustered recurrences. Results: The majority of children were able to wear the monitor for almost 24 hours without too much difficulty; overall, children wore the monitor for a median of 22.25 hours (0.38 â 24hrs). Using the compression software, a median of 100% (91-100) of coughs was retained and 24-hour records were reduced down to around 10% of their original size. There was no significant difference in cough frequency between the three disease groups. The median (range) cough frequency per hour was 3 (0.2 to 18) coughs/hour (c/h), 4 (0.5 to 37) c/h, and 4 (0.5 to 27) c/h for asthma, CF, and PCD groups respectively (p=0.3). Cough frequency in children was significantly greater during the day and reduced during sleep in all disease groups. There was a significant difference in the 24-hour cough frequency between the exacerbation and stable asthma group (median 11 (0-27) vs. 3 (0-5), p=0.004). The 24-hour pattern revealed a substantial variability in peak timing of cough in each respiratory disease. Children with asthma peaked in the early evening, those with CF in the morning, and those with PCD in the afternoon. No difference was found in the circadian cough rate, when divided into 6 4-hour time periods, either between the three diseases (p=0.18) or between stable and exacerbation phases among the asthmatic children (p=0.14). A significant difference was seen in the 24-hour total cough frequency between asthmatic children (median 4c/h; range 1-18) and adults (median 1 c/h; range 0.3-16); p=0.001. The temporal pattern of recurrence of cough events is non-randomly distributed over time, and this was best described by the Weibull model in the majority of the 24hr cough, day-time cough and night-time cough recordings in children and adults. The cough events appear to cluster together in time, with the probability of a second cough being initially high and decreasing with time. Conclusion: This thesis has demonstrated that the VitaloJAK⢠semi-automated cough monitor provides an accurate estimate of cough frequency in children (sensitivity 100%) while significantly reducing the time required for analysis. A substantial variability in the timing of peak cough frequency exists in each respiratory disease and this might reflect different mechanisms of cough in each disease. Sleep appears to significantly reduce cough in all the diseases studied, both when disease is stable and exacerbating. In both asthmatic children and adults, the recurrence pattern of coughs is clustered and can be described by a Weibull distribution. This work has set a foundation for further investigation of the cough frequency and 24 hour cough circadian patterns in children.
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Bogdan, Sven. "Das Xenopus Homolog von Seven in absentia (XSiah-2) Bedeutung eines neuen Interaktionspartners von DCoH/PCD in der Entwicklung des Vertebraten-Auges /." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962834769.
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Ferreira, Gilberlan de Freitas. "Emprego de simulação no controle de qualidade em cartografia aplicado a modelos digitais de superfícies oriundos de sensores orbitais segundo PEC-PCD." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/10738.
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As informações e características com respeito ao relevo são de fundamental importância para o planejamento e a execução de obras de engenharia. Atualmente, além do método convencional de obtenção de dados altimétricos através de levantamento topográfico, existem novos métodos e tecnologias para obtenção desses dados dentre os quais se destaca a estereoscopia de imagens orbitais, a interferometria SAR (Radar de Abertura Sintética) e o perfilamento a laser. Considerando a facilidade de aquisição de várias fontes de informações altimétricas que são disponibilizadas na internet, a qualidade altimétrica dos MDSs obtidos a partir de sensores orbitais tem recebido importante destaque. Pesquisas têm sido direcionadas no desenvolvimento de metodologias para a geração e validação de dados altimétricos de diferentes sensores. Dessa forma, a presente pesquisa apresenta a análise comparativa da qualidade posicional altimétrica dos modelos SRTM, ASTER GDEM e TOPODATA, utilizando diferentes tipos de amostragem e a aplicação de simulação com diferentes tamanhos amostrais, tendo como referencia dados de maior precisão, obtidos através de aerofotogrametria e levantamento via GNSS. Todo o trabalho levou em conta o Padrão de Exatidão Cartográfica dos Produtos Cartográficos Digitais (PEC-PCD), definido na nova norma de qualidade, considerando a abordagem proposta pela CONCAR (2011) no Brasil.
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Sousa, Amanda Bezerra de. "Dimensionamento de cisternas e proposta de tipologias de volume para regi?es pluviais homog?neas." PROGRAMA DE P?S-GRADUA??O EM ENGENHARIA SANIT?RIA, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/22578.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
A ado??o de sistemas de capta??o de ?gua de chuva como fonte de ?gua pot?vel ? uma pr?tica disseminada em diversas partes do mundo. A efici?ncia do sistema est? diretamente ligada ao dimensionamento adequado do reservat?rio. O objetivo desta pesquisa ? delimitar zonas pluviais homog?neas para o Estado do Rio Grande do Norte, avaliar a varia??o de volumes de cisternas com diferentes m?todos de dimensionamento para estas zonas e, por fim, determinar tipologias de volumes de cisternas para regi?es com regimes pluviais semelhantes. Para a delimita??o das zonas pluviais homog?neas foi utilizado a precipita??o m?dia anual e o ?ndice PCD (Precipitation Concentration Degree) que permite estimar a forma como a precipita??o se distribui ao longo dos meses do ano. Os resultados mostraram que a divis?o em 6 grupos homog?neos contempla toda a varia??o das caracter?sticas pluviais para o Estado. Quanto ? avalia??o dos m?todos de dimensionamento, p?de-se concluir que os m?todos Andrade Neto, Rippl, Simula??o, YAS, Pr?tico Australiano e Efici?ncia de 80% s?o apropriados, visto que os m?todos apresentam varia??o dos volumes condizente com a varia??o das caracter?sticas pluviais. Por fim, ? poss?vel estabelecer tipologias de volumes de cisternas que possam atender ?s situa??es diversas que existem na pr?tica. No caso do Estado do Rio Grande do Norte, podem-se utilizar seis volumes de cisternas diferentes: 3, 5, 8, 12, 16 e 18 m?. Apenas 7% das fam?lias avaliadas necessitam de uma cisterna de 16 m? para atender satisfatoriamente ?s suas demandas, isso demonstra que o volume utilizado para todas as situa??es ? o volume adequado para uma pequena parcela das fam?lias, comprovando a necessidade de utiliza??o de volumes distintos.
The adoption of catchment systems of rainwater as source of drinking water is a disseminated practice in many parts of the world. The system efficiency is directly connected to the suitable sizing of the reservoir. The aim of this research is delimit homogeneous pluvial zones to the Rio Grande do Norte State, to assess the variation of volumes of the cistern for regions with similar rain regimes. For delimitation of the homogeneous pluvial zones was used the mean annual precipitation and the PCD (Precipitation Concentration Degree) that allows to estimate the way as the precipitation distributed over the months of the year. The results show that the division in 6 homogeneous groups contemplates all the variation of rainfall characteristics for the. The methods evaluation of the sizing, it cans conclude that the methods Andrade Neto, Rippl Simula??o, YAS, Pr?tico Australiano and Efficiency of the 80% are appropriate, whereas the methods presents variation of the volumes consistent with variation in rainfall characteristics. Lastly, it is possible establish typologies of cistern volumes that can meet the diverse situations that exist in practice. In the case of the State of Rio Grande do Norte, we can used six volumes of different cisterns: 3, 5, 8, 12, 16 e 18 m?. Only 7% of available families need of a cistern of 16 m? for attend satisfactorily their demands, this show that the volume used for all the situations is the adequate volume for a small portion of families, proving the need to use different volumes.
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Macháček, Martin. "Měření doby života nosičů proudu ve strukturách křemíkových solárních článků." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217834.
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This thesis deals with a lifetime measurement of current carriers in silicon solar cell structures. In the first chapter there is a description of several recombination models and their participation at a final effective lifetime value. By using these recombination models in a computer simulation it is possible to receive approximate evaluation of some important silicon solar cell structure parameters. The PC1D simulation program was used for this thesis. For the lifetime measurement of real test-wafers two methods were used: QSSPC (quasi-steady-state photoconductance) and MW-PCD (microwave photoconductance decay). There is a detail description of these methods, used measurements machines and differences between both of them in the chapter four. The main objective of the thesis is mentioned in the last chapter, which is mainly focused on a chemical passivation of silicon wafers and deals with a problem of post-passivation wafer cleaning. There are three passivation techniques mentioned: the iodine in ethanol solution, the iodine and polymer in ethanol solution and the quinhydron in methanol solution. In two cases a results, that are adequate to return the tested wafers in the manufacture process, were achieved.
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Bastianelli, Fiorenza. "Caratterizzazione dei meccanismi di morte cellulare programmata in colture cellulari di Medicago truncatula e Lotus japonicus." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3426382.
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Suspension cell cultures are a good system to stidy PCD. In Medicago truncatula natural and induced senescence were investigated, focusing on mitochondria. Il Lotus japonicus PCd indeced by salycilic acid were analysed.
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Erkers, Louise. "Chemical Interactions between tool and Aluminium alloys in metal cutting." Thesis, KTH, Materialvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291358.
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Aluminium applications in automotive will increase by 25 % over the next decade, mainly driven by the electrification and the reduction of fuel consumption. This diploma work aims to increase the understanding of the chemical interactions between aluminium alloys and typical tool systems in metal cutting. First the temperature at the tool-chip interface was estimated by FEM simulations, using the software AdvantEdge. Thereafter the chemical interaction of the tool-chip interface was calculated at the simulated temperature using the Thermo-Calc software. The thermodynamic data and descriptions of the multicomponent systems used where found in the literature, assessed by other authors, but critically reviewed for the use in this work. The results of the FEM simulations indicate that the temperature for machining aluminium with PCD and cemented carbide is between 60-80 % of the melting temperature of Al7wt %Si alloy. The calculations of the chemical interaction in turn results in that several hard precipitates can stick to or transform on the surface of the workpiece or tool-chip interface, for example SiC, Al4C3 and evidently diamond from the tool. This work concluded that more predictive modelling is needed to refine the results and the results from this work needs to be confirmed with experiments. The results show that the modelling can predict the reaction phases at the tool-chip interface, this can be used as input for the tool wear mechanisms during development of tooling solutions.Aluminium användningen inom fordonsindustrin förväntas öka med 25 % under det närmsta decenniet, främst på grund av elektrifiering men också för att för att minska bränsleförbrukning. Målet med detta examensarbete är till att öka förståelsen för de kemiska interaktionerna mellan aluminiumlegeringar och typiska verktygssystem vid metallskärning, framförallt vid bearbetning av aluminiumlegeringar innehållande kisel med ett TiN-belagt PCD-verktyg och icke-belagda verktyg. Detta gjordes genom prediktiva FEM-simuleringar av temperatur, med hjälp av mjukvaran AdvantEdge. Parallellt med detta skapades databaser för simulering av den kemiska interaktionen mellan skär och bearbetningsmaterial i programvaran Thermo-Calc. De termodynamiska data och beskrivningarna av de termodynamiska system som används var bedömda av andra författare men kritiskt granskade för användning i detta arbete. Resultaten av FEM-simuleringarna gav den beräknade temperaturen för bearbetning av aluminium med PCD ligger någonstans mellan 60-80 % av smälttemperaturen för Al7wt % Si-legering. Beräkningarna av den kemiska interaktionen resulterar i sin tur i att flera hårda utskiljningar kan fastna på eller transformera på ytan mellan arbetsstycket och verktyget, till exempel SiC, Al4C3och diamant från verktyget. Resultaten från detta arbete visar att det går att förutsäga fasomvandlingar mellan skär och arbetsstycket, samt att detta kan användas som indata för skärförslitning under utvecklingen av verktygslösningar.
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SOBRINHO, Ramiro Augusto de Miranda. "Estudo da acessibilidade em um prédio da Faculdade de Direito do Recife/UFPE." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/22666.
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DISSERTAÇÃO Ramiro 25 janeiro 2017.pdf: 3027670 bytes, checksum: 767c13dc68901ac299c9f8e5065e448f (MD5)Made available in DSpace on 2017-12-22T12:07:41Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) DISSERTAÇÃO Ramiro 25 janeiro 2017.pdf: 3027670 bytes, checksum: 767c13dc68901ac299c9f8e5065e448f (MD5) Previous issue date: 2016-12-07
O objetivo dessa dissertação é diagnosticar e propor recomendações para a acessibilidade de Pessoas com Deficiência (PcD) e Pessoas com Mobilidade Reduzida (PMR), usuárias do espaço do prédio sede da Faculdade de Direito do Recife (FDR). O foco da pesquisa foi avaliar a estrutura física, equipamentos e mobiliário, em especial àqueles localizados ao longo da Rota Acessível, implantada no ano de 2015. Na metodologia, foi desenvolvida uma pesquisa exploratória e descritiva, utilizando-se de dados documentais legais, de bibliografia sobre o tema e da estratégia do estudo de caso. Para tanto, foram efetuadas entrevistas semiestruturadas, aplicação de planilhas de acessibilidade e análise de plantas arquitetônicas do local. As entrevistas esclareceram a percepção das PcD e PMR, com o intuito de serem identificados os constrangimentos sofridos no espaço físico da FDR. As planilhas de acessibilidade tiveram o propósito de verificar a situação do espaço acessível na FDR, em conformidade com a legislação específica para as PcD, e ênfase na NBR 9050/2015. Foram comparadas as plantas arquitetônicas da rota acessível com a real situação do espaço. Realizaram-se observações diretas com registro em fotografias e gravador de voz. As informações coletadas foram analisadas qualitativamente. O exame dos dados da pesquisa demonstrou que há necessidade de alterações no ambiente para promover segurança e comodidade. Depois de caracterizados os resultados, constatou-se que a acessibilidade no prédio é parcialmente atendida, e foram identificadas as áreas que necessitam de intervenções, ajustes e melhorias. Ao final, sugere-se à administração central da FDR o desenvolvimento de ações que contemplem a acessibilidade. A dissertação buscou aprofundar a temática da acessibilidade, no âmbito da Universidade Federal de Pernambuco (UFPE), promover a sua reflexão, e assim possibilitar a autonomia universal no uso dos seus espaços.
The aim of this dissertation is to analyze and to propose recommendations for accessibility of disabled persons (PcD in Portuguese) and persons with reduced mobility (PMR in Portuguese), user of the headquarter building of Faculdade de Direito do Recife (FDR) dependencies. The research focus was evaluate physical structure, equipments and furnishings, in a special way those located throughout accessible route, established in the year 2015. The methodology developed based on an exploratory and descriptive research, handling legal document data, bibliography data and case study strategy. Therefore, it were accomplished semi-structure interviews, accessibility spreadsheets and building blueprints analysis. The interviews have brought to the light the PcD and PMR persons’perception to intent to identify the awkwardness suffered by them in the FDR dependencies. The accessibility spreadsheets have had purpose to verify the accessible space conditions in the FDR in compliance with specific legislation to PcD persons andemphasis in NBR 9050/2015. A comparison between arquitectonic blueprints of the accessible route and on the spot condition carried out. It were accomplished direct observations with register in photography and voice recorder. It was made a data collected qualitative analysis. The data exam demonstrated the necessity to carry out modifications into the environment to promote safe and wellbeing. As result of data characterizing, it realized the accessibility conditions werenot properlyattended.In addition, improvement opportunities, interventions and adjustments were found. At the end, the report suggest to central administration of FDR developing actions that include accessibility conditions. The dissertation reached deepen itself onto the accessibility thematic at the Universidade Federal de Pernambuco (UFPE) ambit, to promote pensiveness about theme, and this way enable universal autonomy inside the academy spaces.
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PEREIRA, Olavo Antônio de Almeida. "Os reflexos da emenda no Lei de Cotas Sociais para as PCD no acesso e na acessibilidade no Instituto Federal Sul-Riograndense Campus Pelotas." Universidade Catolica de Pelotas, 2017. http://tede.ucpel.edu.br:8080/jspui/handle/tede/674.
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This dissertation aimed to verify whether the Instituto Federal Sul-Rio-Grandense - Campus Pelotas is prepared to receive disabled people (DP). The research occurred in the Campus Pelotas, especially observing the adaptations for accessibility in the campus, in documents from the webpage ifsul.edu.br/processoseletivo/edital, and in the Programa Q-Acadêmico of the academic records, which contain the registration data. As referential, we used subjects like: Estado Brasileiro, social policies, public higher education, affirmative action policies, with emphasis on the law nº 12712/12, and on the recent amendment of law nº 13409/16, which unlike the previous veto, it included DP in social quotas since 2017. The research was bibliographical and documental and it developed by the means of a qualitative approach, with a support of quantitative data in graphs related to the admission of disabled students. Since the DP quotas in selective process of the public notice nº 100/2017 were implemented, we noticed that there was an increase of DP enrolled in this modality in several campi. This can help in the increasing of DP in courses of this campus, once it is prepared to receive this people, with ramps, elevators and adapted toilets. Keywords: Disabled People. Social Quotas Policy. Accessibility.
A presente dissertação tem como objetivo, verificar se o Instituto Federal Sul-Rio-Grandense Campus Pelotas está preparado para receber as Pessoas com Deficiência (PcD). O estudo da pesquisa foi no Campus Pelotas, especificamente em observações das adaptações para acessibilidade no campus, em documentos na página do ifsul.edu.br/processo/seletivo/edital e no Programa Q-Acadêmico dos registros acadêmicos, responsável por conter dados das matriculas. Como referencial foram utilizados os temas Estado Brasileiro, políticas sociais, ensino superior público, política de ações afirmativas, com ênfase na Lei 12.712/12, e a recente emenda da lei 13.409/16, que ao contrário do veto anterior, incluiu a partir de 2017 as PcD na cotas sociais. A pesquisa foi bibliográfica e documental e desenvolveu-se por meio de uma abordagem qualitativa, com apoio de dados quantitativos em gráficos, referentes ao ingresso de alunos com deficiência. Desde a implantação de cotas para as PcD no processo seletivo do edital 100/2017 notou-se um aumento do número de escritos nesta modalidade (PcD) em vários campus, o que poderá ajudar no aumento do ingresso de alunos com deficiência nos cursos do campus Pelotas. Já que o campus Pelotas está preparado, com rampas elevadores e banheiros adaptados, acessíveis para receber este público.
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Ni, Nyoman Ayu Dewi [Verfasser], Carsten [Akademischer Betreuer] Lüder, Uwe [Akademischer Betreuer] Groß, and Ernst A. [Akademischer Betreuer] Wimmer. "Molecular and Functional Characterization of Programmed Cell Death (PCD) in Toxoplasma gondii / Ayu Dewi Ni Nyoman. Gutachter: Uwe Groß ; Ernst A. Wimmer. Betreuer: Carsten Lüder." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/104430703X/34.
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Silva, Cristiano Alves da. "Avaliação da acurácia dos ortomosaicos e modelos digitais do terreno gerados por VANT e sua aplicação no cálculo de volume de pilhas de rejeito da Pedra Cariri." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/20034.
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SILVA, Cristiano Alves da. Avaliação da acurácia dos ortomosaicos e modelos digitais do terreno gerados por VANT e sua aplicação no cálculo de volume de pilhas de rejeito da Pedra Cariri. 2015. 146 f. Dissertação (Mestrado em Geologia)-Universidade Federal do Ceará, Fortaleza, 2015.Submitted by Vitor Campos (vitband@gmail.com) on 2016-10-05T23:02:45Z No. of bitstreams: 1 2015_dis_casilva.pdf: 5268107 bytes, checksum: c3a0b833ecc7a09a72b7062054e67836 (MD5)
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Recently, the technological advancement of Unmanned Aerial Vehicles (UAVs) has been exponential. This equipment are capable of generating remote sensing products of high accuracy at low operating costs, carrying out activities previously performed exclusively by manned aircraft. In this context, the National Department of Mineral Production (DNPM), aiming to maximize their actions of oversight and management of mining, has partnered with the University of Brasilia (UnB) for the development of a small UAV capable of generating orthomosaics and Terrain Digital models (TDM) with high accuracy. To achieve such objective, UnB has developed a 2,5 kg aircraft equipped with a small-format camera, nonmetric, capable of obtaining high-resolution photographs, after being processed through method of computing similarities between overlapping images, generates a cloud of points of the three-dimensional coordinates (x, y, z) of the surface, allowing to generate orthomosaics and TDMs. However, UAV technology is still considered emerging, being common questions about the survey method, used sensor and mainly accuracy of obtained results, a fact that motivated the elaboration in this case study. The main purpose this research is to evaluate of the accuracy of orthomosaics and TDMs generated from the data collected by the UAV developed by UnB, as well it's application in calculating the volume of laminate sedimentary limestone tailings piles of Araripe Basin in Ceará, extracted in the form of tiles in natura marked under the name of Cariri Stone, compared it's accuracy with the results obtained with Global Navigation Satellite System (GNSS) and Light Detecting and Ranging (LIDAR) technologies, more commonly used by mining for this purpose. To evaluating the accuracy was used hypothesis testing method, from the trend and precision of analysis, and the results classified according to the Standard Cartographic Accuracy of Digital Cartographic Products (PEC-PCD). After the experiments performed, it was possible to acknowledge that the UAVUnB/DNPM is capable of generating with accuracy orthomosaics and MDTs, consistent with those obtained by conventional aerial photography, if properly oriented by ground control points. In this case study, the UAV showed better results when compared with modeling performed through GNSS and LIDAR technologies.
Nos últimos anos foi exponencial o avanço tecnológico dos denominados Veículos Aéreos Não Tripulados (VANT) Estes equipamentos são capazes de gerar produtos de sensoriamento remoto de elevada acurácia com baixo custo operacional desempenhando atividades antes executadas exclusivamente por aeronaves tripuladas Neste contexto o Departamento Nacional de Produção Mineral (DNPM) para maximizar suas ações de fiscalização e gestão da mineração firmou parceria com a Universidade de Brasília (UnB) para desenvolvimento de um VANT de pequenas dimensões capaz de gerar ortomosaicos e Modelos Digitais do Terreno (MDT) de alta acurácia Para alcançar esse objetivo a UnB desenvolveu uma aeronave de 25 kg equipada com uma câmera não métrica capaz de obter fotografias de alta resolução que após processadas utilizando o método de correlação de imagens sobrepostas gera uma nuvem de pontos das coordenadas tridimensionais da superfície permitindo a geração de ortomosaicos e MDTs Contudo a tecnologia VANT ainda é considerada emergente São comuns indagações sobre o método de levantamento o sensor utilizado e principalmente a acurácia dos resultados obtidos fato que motivou a elaboração deste estudo de caso O objetivo principal desta pesquisa foi realizar a avaliação da acurácia dos ortomosaicos e MDTs gerados a partir dos dados coletados pelo VANT desenvolvido pela UnB bem como sua aplicação no cálculo do volume de pilhas de rejeito do calcário sedimentar laminado da Bacia do Araripe no Ceará comercializado com o nome de Pedra Cariri sendo comparada sua acurácia com as obtidas pelas tecnologias Global Navigation Satellite System (GNSS) e Light Detecting and Ranging (LIDAR) mais utilizadas pelo seguimento da mineração para esta finalidade Para avaliação da acurácia foi usado o método de testes de hipóteses a partir da análise de tendência e precisão sendo os resultados classificados de acordo com o Padrão de Exatidão Cartográfica dos Produtos Cartográficos Digitais (PEC-PCD) Após os experimentos realizados foi possível constatar que o VANT-UnB/DNPM é capaz de gerar ortomosaicos e MDTs de alta acurácia compatíveis com os obtidos por aerofotogrametria convencional desde que devidamente orientado por pontos de apoio de solo apresentando melhor acurácia no cálculo de volume neste estudo de caso se comparado com a modelagem realizada com as tecnologias GNSS e LIDAR.
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Solčanský, Marek. "Chemická pasivace povrchu křemíkových desek pro solární články." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217864.
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This master´s thesis deals with an examination of different solution types a for the chemical passivation of a silicon surface. Various solutions are tested on silicon wafers for their consequent comparison. The main purpose of this work is to find optimal solution, which suits the requirements of a time stability and start-up velocity of passivation, reproducibility of the measurements and a possibility of a perfect cleaning of a passivating solution remainig from a silicon surface, so that the parameters of a measured silicon wafer will not worsen and there will not be any contamination of the other wafers series in the production after a repetitive return of the measured wafer into the production process. The cleaning process itself is also a subject of a development.
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Mattioli, Federico. "Problema di Cauchy-Dirichlet per l'equazione del calore." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12042/.
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In quest'elaborato si risolve il problema di Cauchy-Dirichlet per l'equazione del calore, prendendo come oggetto d'esame una sbarra omogenea. Nel primo capitolo si studiano le serie di Fourier reali a partire dalle serie trigonometriche; vengono dati, poi, i principali risultati di convergenza puntuale, uniforme ed in L^2 e si discute l'integrabilità termine a termine di una serie di Fourier.
Il secondo capitolo tratta la convergenza secondo Cesàro, le serie di Fejèr ed i principali risultati di convergenza di queste ultime. Nel terzo, ed ultimo, capitolo si risolve il Problema di Cauchy-Dirichlet, distinguendo i casi in cui il dato iniziale sia di classe C^1 o solo continuo; nel secondo caso si propone una risoluzione basata sulle serie di Fejér e sul concetto di barriera ed una utilizzando il nucleo di Green per l'equazione del calore.
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Weidemann, Eva. "Waste incineration residues : Persistent organic pollutants in flue gas and fly ash from waste incineration." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92765.
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Modern societies produce large quantities of municipal solid waste (MSW), which is commonly disposed of by incineration. This has several advantages: it reduces the waste’s volume and sterilizes it while also enabling energy recovery. However, MSW incineration has some notable disadvantages, the most widely debated of which is probably the production and release of persistent organic pollutants (POP) such as polychlorinated dibenzofurans (PCDF), dibenzo-p-dioxins (PCDD), biphenyls (PCB) and naphthalenes (PCN). Of the 210 PCDF and PCDD congeners, 17 are toxic, with hormone-disrupting and carcinogenic properties. Twelve of the 209 PCB congeners and at least 2 of the 75 PCN also exhibit such properties. These POP form in the post-combustion zones of MSW incineration plants and are removed from the flue gas using filtering devices that trap them in the fly ash This thesis concerns the formation and degradation of POP in processes related to MSW incineration. The first paper describes a case study in which PCDD were forming in filters designed to remove them from flue gases, causing emission-related issues in a full-scale MSW incineration plant. It was shown that the PCDD formation was probably due to chlorophenol condensation on the filters’ surfaces. The second paper describes the validation of a cooling probe designed to prevent POP formation during high temperature (>450 °C) flue gas sampling. The results obtained also confirmed that PCDF and PCDD formation takes place at temperatures below 600 °C. In the third paper, three different fly ashes were subjected to thermal treatment under an inert atmosphere in a rotary kiln and in sealed ampoules at 400 °C. The concentrations, degrees of chlorination and congener profiles of the POP in the treated ashes and emitted gases were compared to those for the untreated ashes. The trends observed for PCDF mirrored those for PCN, while the trends for PCDD closely resembled those for PCB. The PCDF congener profiles of the kiln ash were similar regardless of the initial ash composition, suggesting that the mechanisms of PCDF formation were similar in all cases. The fourth paper describes the surface characterization of the three fly ashes studied in paper three by SEM, EDX, XPS and XRD. In addition, the thermal desorption and subsequent degradation of POP from the ashes was studied at temperatures of 300-900 °C. The composition of the gases released as the temperature increased differed between the ashes and depended on their composition. Doping experiments using isotopically labelled PCDF and PCDD suggests that PCDD desorbed at lower temperatures than PCDF. This thesis examines several problems relating to POP formation during MSW incineration, from sampling to the ultimate fate of incineration residues. The results obtained illustrate the wide range of processes that contribute to thermal POP formation and degradation during and after MSW incineration.Förbränning av hushållssopor är en vanlig metod för att hantera ett växande avfallsproblem. Metoden har flera fördelar, såsom minskning av volym och vikt, sterilisering och energiåtervinning. Sopförbränning har dock vissa nackdelar och det mest debatterade är sannolikt utsläpp av persistenta organiska föroreningar (POPs) som polyklorerad dibensofuran (PCDF), dibenso-p-dioxin (PCDD), bifenyl (PCB) och naftalen (PCN). Det finns totalt 210 PCDF- och PCDD- kongener, med mellan ett till åtta klor på kolskelettet, varav 17 är giftiga med hormonstörande och cancerframkallande egenskaper. Även tolv av totalt 209 PCB-kongener samt minst två av totalt 75 PCN-kongener uppvisar liknande egenskaper. Dessa klorerade organiska föroreningar bildas då rökgaserna kyls ner i sopförbränningsanläggningarna och avlägsnas från rökgaserna med hjälp av filter och hamnar i flygaskan. Denna avhandling handlar om bildning och nedbrytning av POPs i sopförbränningsrelaterade processer. Den första artikeln är en fallstudie där PCDD bildas i filtren i en fullskalig sopförbränningsanläggning. Bildningen ledde till förhöjda halter organiska föroreningar i rökgaserna, vilket ledde till ökade utsläpp. Den funna bildningsvägen för PCDD i filtren befanns sannolikt bero på kondensation av klorfenoler på filterytorna. Den andra artikeln är en valideringsstudie av en kylprob avsedd att användas vid rökgasprovtagning vid hög temperatur (> 450 °C) för att undvika bildning av POPs under provtagningen. Studien bekräftade att majoriteten av PCDF- och PCDD- bildning i rökgaser från sopförbränning sker vid temperaturer under 600 °C. I den tredje artikeln berättas om behandling av tre olika flygaskor från olika sopförbränningsanläggningar. Askorna behandlades vid 400 °C i inert atmosfär i både en roterugn och i förseglade ampuller. De resulterande koncentrationerna, kloreringsgraderna och kongenprofilerna av de organiska föroreningarna jämfördes. Likheter hittades mellan PCDF och PCN, medan PCDD och PCB betedde sig på ett annat sätt. Studien fann också att PCDF kongenprofiler i aska som behandlats i roterugnen liknade varandra, oberoende av askornas sammansättning, vilket tyder på en liknande bildningsväg. För den fjärde artikeln, genomfördes ytkarakterisering (SEM, EDX, XPS och XRD) på de tre flygaskorna från artikel tre som sedan hettades upp från 30 °C till 900 °C i vacuum. Det som frigjordes på grund av uppvärmningen samt nedbrytningsprodukter från askorna studerades med hjälp av masspektrometri och infraröd spektroskopi. Studien fann att de gaser som frigjordes när temperaturen ökade skilde mellan askorna, beroende på deras sammansättning. Studien fann också att när aska dopad med isotopmärkt PCDF och PCDD utsattes för samma behandling, frigjordes PCDD vid lägre temperatur än PCDF. Denna avhandling berör flera aspekter av problematiken kring klorerade organiska föroreningar som bildas vid sopförbränning, från provtagning till hur man ska hantera flygaskan. Avhandlingen belyser även olika typer av bildning och nedbrytning av POPs i varma processer kopplade till sopförbränning.
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Delvart, Vincent Dekeuwer-Défossez Françoise. "Les conséquences du divorce sur les libéralités entre époux et les avantages matrimoniaux." [S.l.] : [s.n.], 2005. http://frodon.univ-lille2.fr:8180/sdx/pcd/ed74/2005/delvart.
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Stark, Marie Luise [Verfasser]. "Transfer von Dioxinen (PCDD), Furanen (PCDF) und polychlorierten Biphenylen (PCB) aus dem Futter in ausgewählte Gewebe wachsender Schafe / Marie Luise Stark." Berlin : Freie Universität Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:188-refubium-31051-8.
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Yang, Yun. "Temperature dependent PCDD/PCDF product distributions from phenols." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/20182.
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Jang, Kyoung-Jin. "Mitochondrial function provides instructive signals for activation-induced B cell fates." Kyoto University, 2015. http://hdl.handle.net/2433/199208.
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Fredlund, Viktor, and Andreas Tollerup. "Valuation - The issue of illiquidity : A qualitative retake on illiquidity discounts in the context of private company valuation on the Swedish market." Thesis, Umeå universitet, Företagsekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-99826.
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A private company lacks a direct observable market value and several situations may require a practitioner to compute the value of a private company. Since most of the valuation methods in use are based on data derived from the public stock markets certain adjustments may be appropriate when valuing a private company. Marketability and liquidity is said to be one of the more observable differences between a public and a private company. This implies that the shares in a private company have a lack of marketability and liquidity in comparison to the shares in a public company, which practitioners may have to adjust for. Several quantitative studies are conducted on the subject in order reassure price differences between public and private companies, namely a private company discount (PCD). Furthermore, several quantitative studies strive to establish a general and standardized cost for lack of marketability (liquidity) expressed as the illiquidity discount or the discount for lack of marketability (DLOM). These studies have different perceptions and use different hypothesis to identify illiquidity, which in turn will lead to a large span of different discounts. Essentially, earlier research examines assets marketability and liquidity with the assumption of them being equal in all other aspects. Professional practitioners constantly seek guidance in these studies to justify their estimated and applied illiquidity discount/DLOM when performing a valuation on a privately held company. Furthermore, we have also observed survey-studies adopting a more qualitative method in order to appreciate the level of discounts applied in a valuation by professional practitioners. Consequently, this sea of studies provides the practitioner with a discount that ranges from 5% to 60% to take a stand on. The impossibility to determine the most adequate theory contributes to the inconsistency of how this issue is handled in reality by market participants and courts. In our study we first provide the reader with a rigorous literature study, which describes earlier research on the subject of illiquidity discount/DLOM. We conclude that research has gone one step too far when conducting all of these quantitative studies. This is why we conduct our own empirical data through semi-structured in-depth interviews with professional valuation experts on the Swedish market. This makes our approach a retake on the issue in order to generate suggestions to further studies. What we find is that all of the independent consultants, primarily, does not apply a discount when valuing a majority interest due to the paradigm on the Swedish market. In contrast, the private equity fund manager, which only acquires majority interest, can use this type of discounts in their dependent valuation of majority interests. However, when valuing a minority interest the independent valuation consultants use quantitative empirical studies to derive a starting point of the discount. The level of the discount is then estimated upon the purpose of the valuation and firm-specific variables, which all of the participant’s states to be the most important ones when estimating a illiquidity discount/DLOM. Based on these results we argue that one should be very careful when taking guidelines from quantitative empirical studies. Our interpretation is that the level of illiquidity/DLOM applicable depends on the level of attractiveness, which in turn has a bearing on all firm-specific variables. When it comes to applying the appropriate discount all of the participants argue in favor for a discount-on-value and not as some research suggest; a risk premium added to the discount rate. We also generate adequate suggestions to further studies based on these interviews. Since courts and in particular the Swedish tax-court is inconsistent when approving or rejecting illiquidity discounts/DLOM we suggest legal actions on the issue. Furthermore we suggest a survey-like study in order to catch consensus take on how to estimate the level of discount. In fact, this can be done every year in a similar way as PwC’s market risk premium study is conducted.
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Oosthuizen, G. A. "Innovative cutting materials for finish shoulder milling Ti-6A1-4V aero-engine alloys." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1561.
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Thesis (MScEng (Industrial Engineering))--University of Stellenbosch, 2009.The titanium alloys have found wide application in the aerospace, biomedical and automotive industries. Soaring fuel prices and environmental concerns are the fundamental drivers that intensify the demand situation for titanium. From a machining viewpoint, one of the challenges companies face, is achieving high material removal rates while maintaining the form and function of the part. The ultimate aim for a machining business remains to make parts quickly. Conventional cutting speeds range from 30 to 100 m/min in the machining of Ti-6Al-4V. Milling this alloy faster however is challenging. Although titanium is becoming a material of choice, many of the same qualities that enhance titanium‟s appeal for most applications also contribute to its being one of the most difficult materials to machine. The author explored the potential for Polycrystalline diamond (PCD) inserts in high speed milling of Ti-6Al-4V, by trying to understand the fundamental causes of tool failure. The objective was to achieve an order of magnitude increase in tool life, while machining at high speed, simply by reducing some of the failure mechanisms through different cutting strategies. Tool wear is described as a thermo-mechanical high-cycle fatigue phenomenon. The capability of a higher material removal per tool life is achieved in the case of PCD inserts compared to Tungsten carbide (WC). The average surface roughness produced was relatively low. The collected chips were also analyzed. The work demonstrated progress over the performance reported in current literature. The work confirms that there is a region where a sufficiently high temperature in the cutting zone may contribute to extended tool life, provided that the tool material can withstand these extreme conditions.
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Du, Dong. "Contributions to Persistence Theory." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338304358.
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Graner, Érika Mendes. "Avaliação histocitológica, histoquímica e morfofisiológica da habituação e senescência em pupunheiras mantidas in vitro." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-13112013-162335/.
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A técnica de cultura de tecidos permite a propagação rápida e maciça de propágulos geneticamente semelhantes, isentos de doenças, sendo amplamente empregada para a obtenção de gemas adventícias e embriões somáticos visando principalmente, a multiplicação clonal sob ação de reguladores de crescimento. Resultados satisfatórios foram obtidos com a espécie Bactris gasipaes Kunth. por meio da regeneração direta de gemas adventícias e de embriões somáticos, no entanto, as consequências decorrentes da prolongada manutenção in vitro de espécies perenes como a pupunheira, não estão elucidadas, sendo que as pesquisas mais expressivas ocorrem com espécies anuais e restritas a órgãos específicos. Considerando que o tempo de cultivo pode promover a senescência e a habituação de determinados tecidos aos reguladores de crescimento, afetando consideravelmente o potencial morfogênico, o objetivo principal do presente trabalho foi investigar a ocorrência destes processos em folhas, raízes e bases caulinares de plântulas e microplantas com um e oito anos de cultivo, respectivamente. Para tanto, o processo de senescência foi monitorado por meio de análises histológicas, ultraestruturais e histoquímicas à detecção de substâncias ergásticas e à fragmentação do DNA, ao passo que o processo de habituação, foi monitorado por meio de análises morfofisiológicas, histológicas e histoquímicas. Os resultados pertinentes ao processo de senescência evidenciaram a ocorrência de intenso processo de morte celular programada nas células de diversos tecidos nas estruturas analisadas das microplantas, sendo que estes eventos foram escassos e limitados às bases caulinares nas plântulas. Além disso, foi observada a presença elevada de plastoglóbulos no interior dos cloroplastos e de compostos fenólicos nas estruturas foliares e radiculares das microplantas. Já, em relação aos resultados obtidos à detecção do processo de habituação nestas microplantas, quando comparados às plântulas, foram detectados problemas relacionados ao alongamento da parte aérea e do sistema radicular, bem como alterações morfológicas nas raízes e uma pronunciada redução no potencial morfogênico das células pré-procambiais em relação às plântulas. Estes resultados evidenciam que a manutenção in vitro de pupunheiras por longos períodos promoveu o envelhecimento dos propágulos em decorrência à senescência generalizada, bem como provavelmente os conduziu ao processo de habituação aos reguladores de crescimento ANA e/ou BAP, inviabilizando a propagação em grande escala desta espécie.The tissue culture technique allows rapid and massive spread of propagules genetically similar, free from diseases, being the technique widely employed to obtain adventitious buds and somatic embryos mainly targeting the clonal multiplication under the action of growth regulators. Satisfactory results have been obtained with the specie Bactris gasipaes Kunth. through direct regeneration of adventitious buds and somatic embryos, however, the consequences from prolonged in vitro maintenance of perennial species such as peach palm are not clear, and the most significant research occur with annual species and restricted to specific organs. Whereas the cultivation time can promote senescence and habituation of certain tissues to the growth regulators, affecting considerably the morphogenic potential, the main objective of this study was to investigate the occurrence of these processes in leaves, roots and stem bases of seedlings and microplants with one and eight years of cultivation, respectively. Thus, the senescence process was monitored by histological, ultrastructural and histochemical detection of ergastic substances and DNA fragmentation, whereas the habituation process was monitored by analyses histologic, histochemic and morpho-physiological. The relevant results from the senescence process showed the occurrence of an intensive process of programmed cell death in cells of various tissues of the analised microplants structures, and these events were rare and limited to the stem bases in the seedlings. Furthermore, it was observed the high presence of plastoglobules inside chloroplast and phenolic compounds in the leaf and root structure of microplants. Already, the results obtained in relation to the detection of the habituation process in these microplants, when compared to the seedlings, were detected problems related to the elongation of shoots and roots, as well as morphological changes in roots and a pronounced reduction in the morphogenic potential of pre procambial cells compared to seedlings. These results demonstrate that the in vitro maintenance of peach palm for long periods promoted the aging of seedlings due to senescence widespread and probably led to the habituation process, to the growth regulators NAA and/or BAP, difficulting the propagation on a large scale of this species.
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Lins, Valéria Cristina Montenegro Batista. "Percepção das pessoas com deficiência sobre a Atenção à Saúde e sua contribuição para a educação médica." PROGRAMA DE PÓS-GRADUAÇÃO EM ENSINO NA SAÚDE, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/25395.
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A Política Nacional de Saúde da Pessoa com Deficiência orienta ações de promoção da saúde, prevenção de incapacidades, melhoria dos mecanismos de informação, capacitação profissional, e organização/funcionamento dos serviços de atenção à saúde. No entanto, as pessoas com deficiência não se sentem assistidas em suas necessidades quando procuram tais serviços. Adicionalmente, a educação médica, em geral, não tem contemplado em seus conteúdos curriculares esse grupo de pessoas, contribuindo assim, para o não reconhecimento das especificidades relacionadas aos vários tipos de deficiência e de aspectos relevantes para o cuidado integral. Esse estudo objetiva compreender a percepção das pessoas com deficiência sobre o atendimento médico recebido nos serviços de saúde, de modo a contribuir para uma formação profissional que atenda às necessidades dessa população específica. O caminho teórico-metodológico percorrido foi a fenomenologia, utilizando a abordagem qualitativa. As técnicas utilizadas para a coleta dos dados foram grupo focal e entrevistas semiestruturadas, de onde emergiram três unidades temáticas: Necessidades das pessoas com deficiência; Serviços de Saúde e Atenção integral à saúde das pessoas com deficiência. Os resultados dessa pesquisa evidenciaram que as pessoas com deficiência, quando recorrem aos serviços de saúde buscando atendimento médico, muitas vezes, se deparam com barreiras presentes nas instituições, tanto no que se refere ao aspecto atitudinal e de comunicação, quanto à acessibilidade e à falta de equipamentos e materiais apropriados ao seu atendimento. Observou-se também a necessidade de sensibilização e capacitação dos profissionais médicos para melhor atendimento e acolhimento às pessoas com deficiência, no sentido de contribuir para que elas se sintam incluídas socialmente e respeitadas na sua condição. Reitera-se a importância do papel da atenção primária no cuidado integral à saúde dessas pessoas, o que se constitui um desafio e provoca uma reflexão sobre a eficácia das práticas atuais e sobre as possibilidades de melhorias futuras. Conclui-se que é necessário que as escolas médicas se comprometam com a temática e possibilitem um ensino voltado para as necessidades em saúde dessas pessoas.
The National Policy on the Health of Persons with Disabilities guides actions of health promotion, disability prevention, improvement of information mechanisms, professional training, organization and operation of health care services. However, persons with disabilities do not feel assisted in their needs when seeking such services. In addition, medical education, in general, has not included in its curriculum content this group of persons, thus contributing to the non-recognition of the specificities related to the various types of disability and aspects relevant to integral care. This study aims to understand the perception of persons with disabilities about the medical care received in health services, so as to contribute to professional training that meets the needs of this specific population. The theoretical-methodological path covered was phenomenology, using the qualitative approach. The techniques used to collect data were focal group and semi-structured interviews, from which emerged three thematic units: Needs of persons with disabilities; Health Services and Comprehensive health care for persons with disabilities. The results of this research showed that persons with disabilities, when they use health services seeking medical attention, often face barriers in the institutions, both at the level of attitudinal and communication, accessibility, to the lack of equipment and materials appropriate to their service. There was also a need for awareness and training of medical professionals to better care and accommodate persons with disabilities, in order to make them feel socially included and respected in their condition. The importance of the role of primary care in the integral health care of these persons is reiterated, and it is a challenge, reflecting on the effectiveness of current practices and the possibilities for future improvements. It is concluded that it is necessary for medical schools to commit themselves to the theme and to provide education aimed at the health needs of these persons.
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Jermany, Joanne Lorna. "Biosynthesis and maturation of the prohormone convertases PC3 and PC2." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295620.
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The prohormone convertases PC2 and PC3 are members of the highly conserved subtilisin-like serine protease superfamily. Targeted to the regulated secretory pathway of neuroendocrine cells they are involved in the proteolytic processing of a number of co-secreted polypeptides. To investigate the nature of their biosynthesis, maturation and possible interaction with the neuroendocrine polypeptide 7B2, a series of mutants were constructed and translated in a novel cell-free in vitro translation/translocation system derived from Xenopus eggs. It was shown that PC3 undergoes rapid (T1/2<10min), autocatalytic maturation, optimally at pH7, in a calcium-independent manner, from an 88kDa proform to an 80kDa mature form, in a proteolytic reaction occurring carboxy-terminal to RSKR83. This indicates the endoplasmic reticulum as the sub-cellular location for PC3 maturation in vivo. Conversely, PC2 matures optimally at pH5.5 in an autocatalytic reaction dependent on millimolar calcium. It was demonstrated that mutation of the PC2 unique oxyanion aspartate282 to asparagine increased its optimal processing pH requirements from acidic to neutral, in a reaction still dependent on millimolar calcium. This infers that the oxyanion aspartate of PC2 influences the pH at which the protease matures. In vitro the role of the neuroendocrine precursor 7B2 in PC2 biosynthesis was shown to be two-fold and pH-dependent. At acidic pH, pro-7B2 acted as an inhibitor of pro-PC2 maturation, whereas under neutral pH conditions pro-7B2 was seen to markedly enhance pro-PC2 maturation. Neither precursor nor mature 7B2 were shown to interact with the PC2 oxyanion mutant, pro- or mature PC3 in vitro. This is consistent with the proposed view that 7B2 specifically interacts with PC2 in the regulated secretory pathway and the association is dependent upon the nature of the PC2 oxyanion aspartate residue.
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Chisholm, A. M. "Oxford City PCG and PCT : a case study of collaboration." Thesis, Oxford Brookes University, 2007. http://radar.brookes.ac.uk/radar/items/c8b866a0-5bf4-b06a-dcfd-3d59e8093840/1.
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In 1997 the New Labour government instigated a period of radical reform for the National Health Service, a key element of which was the establishment across England of Primary Care Groups (PCGs), which subsequently became Primary Care Trusts (PCTs). These were local statutory governance bodies with responsibility to deliver and develop primary care and to improve the health of their local population: complex functions requiring collaboration with a range of organisations and agencies. The central aim of this study was to investigate whether and how PCG/Ts developed and facilitated collaboration within primary care, and between it and other NHS and non-NHS bodies, and to identify factors which enabled and inhibited collaboration. Using a theoretical framework which draws on a critical realist tradition, an approach was adopted to the analysis of organisational change which was attentive not only to rational, incremental processes of change but which took into account the political, cultural and economic context in which PCG/Ts operated. A key element of this context was the strong resemblance between New Labour's prominent `third way' discourse of collaboration and the defining characteristics of a network mode of governance: trust, loyalty, reciprocity and voluntariness. Inductive and deductive approaches were combined to test and develop theory about the interactions between context and organisational form, using multiple qualitative methods within a longitudinal nested case study. The study demonstrated that the locality-wide base of PCG/Ts, their explicit health improvement remit, budgetary arrangements and the presence of clinicians on their governing bodies were aspects of their organisational forms which equipped them to facilitate collaboration. However, over time, certain contradictions became apparent in New Labour's approach to organising the NHS which undermined many of the PCG/T's collaborative processes. This thesis argues that the alignment of the third way discourse with a network mode of governance exemplified 'symbolic politics. ' What was presented as a rational response to complex social problems and fragmentation of public services, was in fact largely a pragmatic political manoeuvre designed to distance itself from the perceived failure of previous administrations' hierarchy and market modes of governance.
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BARBERO, PIERRE. "Les convertases de pro-hormones pc1, pc2 et pc5-a : maturation des precurseurs polypeptidiques et adressage dans la voie regulee de secretion des cellules eucaryotes." Nice, 1999. http://www.theses.fr/1999NICE5296.
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L'obtention de molecules bioactives issues d'un precurseur polypeptidique inactif necessite de nombreuses etapes de maturation post-traductionnelle. Parmi ces etapes, le clivage endoproteolytique au niveau de motifs basiques permet la liberation des peptides du precurseur. Les enzymes realisant cette proteolyse des precurseurs hormonaux polypeptidiques sont qualifiees de pro-hormones convertases (pcs). Actuellement, huits pcs ont ete identifiees et seules pc1, pc2 et pc5-a sont specifiques de la voie regulee de secretion des cellules neuroendocrines. La neurotensine (nt) et la neuromedine n (nn), deux peptides apparentes aux fonctions de type neurotransmetteur/neuromodulateur dans le snc et de type hormonale dans la peripherie, sont synthetises au sein d'un precurseur commun le pro-nt/nn. Le pro-nt/nn est mature de facon differente selon les tissus, engendrant la nt et la nn libres dans le snc, et la nt et des formes intermediaires de maturation (bignt et bignn) dans la peripherie. Nos travaux revelent que pc1, pc2 et pc5-a maturent le pro-nt/nn avec des profils de maturation differents. Pc1 engendre un profil semblable au profil intestinal, de plus, elle est colocalisee avec le pro-nt/nn dans l'intestin de souris. Pc5-a mature le pro-nt/nn avec un profil similaire a celui observe dans la glande surrenale qui se trouve etre riche en pc5. En revanche, pc2 qui engendre une maturation complete du pro-nt/nn avec liberation des peptides nt et nn libres, serait l'enzyme de maturation cerebrale de ce precurseur. De plus, sa colocalisation avec le pro-nt/nn dans l'intestin de rat pourrait rendre compte du profil particulier observe avec l'apparition de nn libre en quantite importante dans ce tissu. Enfin, nous avons montre que la proteine 7b2 qui se lie specifiquement a pc2 est essentielle a l'activation de cette pc en assurant son orientation correcte vers la voie regulee de secretion ou elle peut alors pleinement jouer son role d'enzyme de maturation. Un mecanisme d'adressage plus general via des sequences presentes dans le domaine carboxy-terminal des pcs pourrait rendre compte de la localisation intracellulaire specifique de pc1, pc2 et pc5-a.
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Gangnon, Françoise. "Contribution à l'identification des enzymes impliquées dans la maturation des précurseurs de neuropeptides : caractérisation des prohormone-convertases PC1, PC2 et PC5-A chez la grenouille." Rouen, 2002. http://www.theses.fr/2002ROUES025.
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Les prohormone-convertases (PCs) sont des protéases à sérine de type subtilisine qui clivent les précurseurs des hormones peptidiques et des neuropeptides, généralement, au niveau de doublets basiques, pour générer des peptides actifs. Parmi ces enzymes, seules PC1, PC2 et PC5-A sont adressées vers la voie régulée de sécrétion et, de fait, interviendraient dans la maturation des pro-neuropeptides. Dans le cadre d'un programme d'identification de nouveaux neuropeptides chez la grenouille, nous avons cloné les ADNc codant PC1, PC2 et PC5-A chez cet amphibien. Les trois convertases ont été hautement conservées au cours de l'évolution. Elles sont présentes dans le SNC et en périphérie. Les transcrits de PC1, PC2 et PC5-A de grenouille sont abondamment exprimés dans des régions cérébrales où la présence de différents neuropeptides a déjà été établie. Ces résultats sont en faveur d'un rôle majeur joué par ces enzymes dans la maturation des précurseurs de neuropeptidesProhormone-convertases (PCs) are subtilisin-like serine proteases responsible for the proteolytic cleavage of pro-hormones and pro-neuropeptides, that generally occurs at dibasic sites. Among the different PCs characterized to date, only PC1, PC2 and PC5-A are sorted towards the regulated secretory pathway, suggesting that these three convertases may be involved in the processing of neuropeptide precursors. As part of a program of identification of novel regulatory peptides in the brain of the frog, conducted in our laboratory, we have cloned frog PC1, PC2 and PC5-A cDNAs. The three convertases have been highly conserved during evolution. The tissue distribution of frog PCs revealed that PC1, PC2 and PC5-A are present both in the CNS and in peripheral organs. The frog PCs mRNAs are actively expressed in brain nuclei which contain various regulatory peptides, supporting the view that these enzymes are involved in the processing of neuropeptide precursors
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Braga, Guilherme Pritsch. "O impacto da inclusão de pessoas com deficiência no mercado de trabalho: uma análise da relação entre a inclusão e os resultados de trabalho em equipe." Universidade do Vale do Rio dos Sinos, 2018. http://www.repositorio.jesuita.org.br/handle/UNISINOS/7168.
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Esse trabalho tem como objetivo analisar o impacto da inclusão de pessoas com de deficiência (PcD) em equipes de trabalho. No Brasil, a lei 8.213/91 obriga empresas a partir de 100 funcionários a incluir PcD em seu quadro de colaboradores. Através da pesquisa foi possível entender a influência da legislação nesse processo e o impacto que isso gera nas equipes de trabalho. Para tanto foi buscado teorias que embasassem o tema e indicadores que poderiam ser utilizados para esse objetivo. O tema diversidade em equipes de trabalho e resultados é amplamente discutido no meio acadêmico e empresarial, contudo não contempla as pessoas com deficiência em suas análises. Foi utilizada essa literatura para embasar a construção de uma survey que foi aplicada em 8 equipes de trabalho de 5 diferentes empresas do Rio Grande do Sul e São Paulo. A pesquisa foi quantitativa, de cunho exploratório e com uma temporalidade longitudinal. Foram definidos 9 conjuntos de indicadores para serem avaliados nos resultados das equipes de trabalho. Foi realizada uma coleta antes da entrada de uma pessoa com deficiência e outra 3 meses após a inclusão desse novo colaborador. Dessa forma, foi possível mensurar o impacto nos resultados das equipes de trabalho antes e depois da inclusão de uma PcD. Ao agrupar as respostas das equipes e realizar a comparação de médias entre a coleta 1 e coleta 2 e não foi encontrada uma diferença significativa na comparação das médias dos conjuntos de indicadores escolhidos. Foi ressaltada a relevância desse resultado tendo em vista as barreiras que existem para a inclusão de PcD no mercado de trabalho. Não haver uma diferença significativa entre a os resultados, antes e depois da inclusão de uma pessoas com deficiência, contribui para desmistificar percepções equivocadas de empresas que possuem resistências na inclusão. Foi também proposto um instrumento para mensuração de resultados das equipes de trabalho, considerando a inclusão de uma pessoa com deficiência como variável. Esse instrumento foi desenvolvido com base em todo referencial de literatura, conhecimentos práticos adquiridos com a pesquisa e análise dos resultados. Dessa forma, deixando um instrumento que pode ser aplicado para estudos no meio acadêmico e empresarial.
This study aims to analyze the impact of inclusion of people with disabilities (PwD) on work teams. In Brazil there is a law that requires companies with 100 employees or more to include PwD in their workforce. Through the research it was possible to understand the influence of the legislation in this process and the impact that this generates on work teams. Were brought theories that supported the theme and indicators that could be used for this purpose. The theme of team diversity and outcomes is widely discussed in academic and business, but does not address people with disabilities in their analysis. This literature was used to base the construction of a survey that was applied in 8 work teams of 5 different companies from Rio Grande do Sul and São Paulo. The research was quantitative, of an exploratory nature and with a longitudinal temporality. Nine sets of indicators were defined to evaluate the results of the work teams. A collect was performed before the entry of one person with a disability and another 3 months after the inclusion of this new employee. This way, it was possible to measure the impact on the results of work teams before and after the inclusion of a PwD. By grouping the team responses and comparing results between collection 1 and collection 2, no significant difference was found in the comparison of the chosen sets of indicators. It was emphasized the relevance of this result considering the barriers that exist for including a PwD in the labor market. Not having a significant difference between the results, before and after the inclusion of people with disabilities, contributes to demystify misperceptions of companies that have resistance in inclusion. It was also proposed an instrument for measuring the results of the work teams, considering the inclusion of a person with disability as a variable. This instrument was developed based on all references of literature, practical knowledge acquired with the research and analysis of the results. Thus, leaving an instrument that can be applied to academic studies and for business.
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Foster, Robert Graham. "Development of a modular in vivo reporter system for CRISPR-mediated genome editing and its therapeutic applications for rare genetic respiratory diseases." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33040.
Full textAbstract:
Rare diseases, when considered as a whole, affect up to 7% of the population, which would represent 3.5 million individuals in the United Kingdom alone. However, while 'personalised medicine' is now yielding remarkable results using recent sequencing technologies in terms of diagnosing genetic conditions, we have made much less headway in translating this patient information into therapies and effective treatments. Even with recent calls for greater research into personalised treatments for those affected by a rare disease, progress in this area is still severely lacking, in part due to the astronomical cost and time involved in bringing treatments to the clinic. Gene correction using the recently-described genome editing technology CRISPR/Cas9, which allows precise editing of DNA, offers an exciting new avenue of treatment, if not cure, for rare diseases; up to 80% of which have a genetic component. This system allows the researcher to target any locus in the genome for cleavage with a short guide-RNA, as long as it precedes a highly ubiquitous NGG sequence motif. If a repair sequence is then also provided, such as a wild-type copy of the mutated gene, it can be incorporated by homology-directed repair (HDR), leading to gene correction. As both guide-RNA and repair template are easily generated, whilst the machinery for editing and delivery remain the same, this system could usher in the era of 'personalised medicine' and offer hope to those with rare genetic diseases. However, currently it is difficult to test the efficacy of CRISPR/Cas9 for gene correction, especially in vivo. Therefore, in my PhD I have developed a novel fluorescent reporter system which provides a rapid, visual read-out of both non-homologous end joining (NHEJ) and homology-directed repair (HDR) driven by CRISPR/Cas9. This system is built upon a cassette which is stably and heterozygously integrated into a ubiquitously expressed locus in the mouse genome. This cassette contains a strong hybrid promoter driving expression of membrane-tagged tdTomato, followed by a strong stop sequence, and then membrane-tagged EGFP. Unedited, this system drives strong expression of membrane-tdTomato in all cell types in the embryo and adult mouse. However, following the addition of CRISPR/Cas9 components, and upon cleavage, the tdTomato is rapidly excised, resulting via NHEJ either in cells without fluorescence (due to imperfect deletions) or with membrane-EGFP. If a repair template containing nuclear tagged-EGFP is also supplied, the editing machinery may then use the precise HDR pathway, which results in a rapid transition from membrane-tdTomato to nuclear- EGFP. Thereby this system allows the kinetics of editing to be visualised in real time and allows simple scoring of the proportion of cells which have been edited by NHEJ or corrected by HDR. It therefore provides a simple, fast and scalable manner to optimise reagents and protocols for gene correction by CRISPR/Cas9, especially compared to sequencing approaches, and will prove broadly useful to many researchers in the field. Further to this, I have shown that methods which lead to gene correction in our reporter system are also able to partially repair mutations found in the disease-causing gene, Zmynd10; which is implicated in the respiratory disorder primary ciliary dyskinesia (PCD), for which there is no effective treatment. PCD is an autosomal-recessive rare disorder affecting motile cilia (MIM:244400), which results in impaired mucociliary clearance leading to neonatal respiratory distress and recurrent airway infections, often progressing to lung failure. Clinically, PCD is a chronic airway disease, similar to CF, with progressive deterioration of lung function and lower airway bacterial colonization. However, unlike CF which is monogenic, over 40 genes are known to cause PCD. The high genetic heterogeneity of this rare disease makes it well suited to such a genome editing strategy, which can be tailored for the correction of any mutated locus.