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Massoudi, Dawiyat. "Approches thérapeutiques des opacités cornéennes par modulation de l'activité de protéinases de la matrice extracellulaire." Toulouse 3, 2001. http://thesesups.ups-tlse.fr/1640/.
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Pour l'être vivant, la vision constitue un élément important pour la perception de l'environnement. Cette fonction peut être altérée par une perte de transparence de la cornée pouvant conduire à une cécité. Les cécités causées par une perte de transparence cornéenne constituent selon l'Organisation Mondiale de la Santé la 3ème cause de cécité dans le monde après la cataracte et le glaucome. Le seul traitement curatif qui existe à l'heure actuelle pour ce type de cécité est la greffe de cornée. Ce traitement bien que satisfaisant demeure imparfait car il se heurte à de nombreuses complications telles que le rejet de greffe. De ce fait, ce travail vise à étudier des solutions alternatives aux greffes de cornée dans le cadre du traitement des opacités cornéennes et comporte deux axes : Un axe thérapeutique qui évalue l'efficacité de protéinases dans la résorption de l'opacité cornéenne. Les études menées au cours de cette thèse ont montré que la surexpression de la MMP-14 par les kératocytes via un vecteur parvoviral induisait une diminution de la sévérité de l'opacité cornéenne installée après traumatisme. Une autre partie de ses travaux a également montré que les protéinases Tolloïdes et leurs activateurs PCPEs (Procollagen C-proteinase enhancer), protéines qui interviennent dans la maturation du collagène joueraient un rôle important dans la cicatrisation cornéenne notamment dans la régénération de la lame basale et pourraient ainsi constituer une cible thérapeutique pertinente. Un axe plus fondamental qui porte sur l'étude de l'implication des collagènes de type XII et de type XIV dans la mise en place et le maintien de l'opacité cornéenne après blessure. Ces molécules font partie des collagènes FACIT (Fibril Associated Collagens with Interrupted Triple helices). Les investigations entreprises lors de cette étude ont montré que l'expression du collagène de type XII augmente au niveau de la cornée après un traumatisme. De manière intéressante, cet accroissement ne s'observe que dans les zones de la cornée où de l'opacité s'est installée. Cette remarque, d'abord effectuée chez l'homme s'avère également valable chez la souris. De plus, des analyses plus poussées de cette protéine réalisées chez la souris ont montré une expression qui varie en fonction du degré d'opacification de la cornée. En d'autres termes, plus l'opacité de la cornée est sévère, plus l'expression du collagène de type XII est importante. Ceci laisse donc supposer que cette molécule jouerait un rôle important dans le maintien de l'opacité au niveau de la cornée. En conclusion, ce travail de thèse a permis de démontrer d'une part, l'intérêt de la modulation de métalloprotéinases dans la résorption de l'opacité cornéenne et d'autre part, l'implication du collagène FACIT de type XII dans le maintien de l'opacité mise en place après un traumatisme cornéenVision constitutes an important element for our perception of the environment. Visual quality can be altered by loss of corneal transparency that can lead to corneal blindness. Loss of corneal transparency represents the 3rd cause of blindness worldwide according to World Health Organization. The only current curative treatment for this type of blindness is corneal transplantation. However, this treatment although satisfactory, faces many complications such as graft rejection. Thus, the purpose of this work was to study alternatives to corneal transplantation in the treatment of corneal opacities. The work consists of two majors goals: A therapeutic axis: This first aim concerns the evaluation of the effectiveness of the modulation of metalloproteinase activity in the resorption of corneal opacity. This project included the examination of the overexpression of the matrix metalloproteinase (MMP) 14 in in vivo mouse corneal scarring. The results showed a decrease of corneal opacity following over expression of MMP14 in the corneal stroma. This project also assessed the variation in the expression of Tolloid proteinases and their enhancers PCPEs (Procollagen C-Proteinase Enhancers) during in vivo corneal wound healing. We observed a significant increase in these proteinases following corneal incision. These observations suggest that these proteinases could play an important role in corneal matrix remodeling observed during wound healing. A more fundamental axis: The purpose of this project was to investigate the implication of FACIT (Fibril Associated Collagens with Interrupted Triple helices) type XII and type XIV collagens in the establishment and maintenance of corneal opacity after injury. We observed an increase in expression of type XII collagen in the cornea after injury, more precisely where opacities persisted. This was demonstrated not only in human corneas, but also in a mouse corneal scarring model. Furthermore, the expression of type XII collagen changed according to the degree of corneal opacity. These results suggest that the type XII collagen molecule could be important in the development and the maintenance of corneal opacity after injury. In conclusion, these projects have demonstrated a novel significance in the modulation of metalloproteinase activity in the resorption of corneal opacity and the implication of the FACIT type XII collagen in the maintenance of opacity after corneal trauma
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Liu, Yiding. "Technologies for Proteomic and Genomic Biomarker Analysis." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1229461302.
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Harsha, Prahladh 1976. "Robust PCPs of proximity and shorter PCPs." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/26720.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references (p. 179-185).
by Prahladh Harsha.
Ph.D.
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Dalas, Florent. "Influence des paramètres structuraux de superplastifiants sur l'hydratation, la création de surfaces initiales et la fluidité de systèmes cimentaires modèles." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS019/document.
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L’emploi d’adjuvants fluidifiants est courant pour tout béton. Ceci permet d’améliorer les propriétés rhéologiques à l’état frais: la fluidité initiale et son maintien pendant les 2-3 premières heures de la vie d’un béton. La compréhension de ce mécanisme d’action est encore partielle pour les PCP (copolymères greffés). Ici, le but a été de tester l’hypothèse selon laquelle l’évolution de la quantité de PCP adsorbé par unité de surface minérale instantanée explique quantitativement l’évolution temporelle de la fluidité au cours de la période d’ouvrabilité.Sur un système inerte (calcite), nous avons confirmé que la fluidité est bien gouvernée par l’adsorption: à même adsorption surfacique, la fluidité de la pâte est quasiment identique quelle que soit la structure du PCP. Par ailleurs sur un système inerte (calcite ou ettringite), la modification de la fonction ionique du PCP fournit une solution pour améliorer la résistance de l’adsorption à la variation de la concentration en sulfates.Deux techniques ont été utilisées pour mesurer l’aire interfaciale au cours de l’hydratation d’un système réactif modèle (aluminate tricalcique, gypse, hémihydrate et calcite): l’adsorption de N2 et la relaxométrie du proton de l’eau. L’adsorption du PCP par unité de surface réelle a été calculée et corrélée à la fluidité de la pâte. La relation simple fluidité/adsorption n’est plus vérifiée ici. La présence de PCP a un impact sur l’hydratation du système et l’augmentation de l’étendue de la surface minérale associée. Les PCP vont augmenter la surface spécifique de l’ettringite qui précipite en modifiant sa morphologie. Cet effet est plus marqué quand la densité de greffage du PCP diminueNowadays the use of superplasticizers admixtures becomes unavoidable for concrete. It allows enhancing the rheological properties at the fresh state: the initial flow and slump retention during the 2-3 first hours of the life of a concrete. The understanding of this mechanism is still partly elucidated for PCE (grafted copolymers). The aim of this thesis was to challenge the assumption of the evolution of the adsorbed amount of PCE per instantaneous mineral surface unit as origin of the fluidity temporal evolution during the workability period.On an inert system (calcite), we confirmed that the fluidity is mainly governed by the adsorption level. Thus for a same surface adsorption density, the fluidity of the paste is roughly similar whatever the structure of the PCE. On an inert system also (calcite or ettringite), the modification of the anionic function provides a technological way to improve the resistance of the adsorption against the variation of the sulfate ions concentration.The surface area of a reactive model system (tricalcium aluminate, gypsum, hemihydrate and calcite) has been measured by two techniques during the workability period: the N2 adsorption (BET) and the water proton relaxometry (RMN). The PCE adsorption per surface unit has been calculated and analysed in link with the fluidity of the paste. In that case, the simple relation, shown on the inert system, is not verified because the presence of PCE has also an impact on the hydration and on the extent of the surface area. Especially PCE lead to increase the surface by changing the morphology of ettringite. The specific surface area of ettringite increases when the grafting density of PCE decreases
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Harsha, Prahladh 1976. "Small PCPs with low query complexity." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/86448.
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Šnédarová, Gabriela. "Sorpce PCP na lignitu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216404.
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Within the framework of this diploma thesis, the sorptive capability of a lignite as a natural adsorbent was applied on an aqueous solution of pentachlorophenol. The aqueous solution of this substance, which is very dangerous for the environment, was prepared in various concentration ranges according to reached solubility. The solubility is noticed in different literatures variously and then is not applicable. That is why it was necessary to find out the ”real“ solubility. The aqueous solution of pentachlorophenol of given concentration was subsequently put to adsorption with exactly defined quantity of the lignite and as a result the adsorptive isotherms were obtained. These isotherms represent the adsorption capability in dependence on the adsorption duration, quantity of used lignite and concentration of pentachlorophenol solution. By the adsorption with duration longer than one hour, the quantity of adsorbed PCP does not increase markedly.
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Vyas, Nikhil S. M. Massachusetts Institute of Technology. "Imperfect gaps in Gap-ETH and PCPs." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122771.
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Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019Cataloged from PDF version of thesis.
Includes bibliographical references (pages 45-47).
In this thesis we study the role of perfect completeness in probabilistically checkable proof systems (PCPs) and give a new way to transform a PCP with imperfect completeness to a PCP with perfect completeness, when the initial gap is a constant. In particular, we show that PCP[subscript c,s][r, q] [mathematical symbol] PCP[subscript 1,s'][r + 0(1), q+ 0 (r)] for c - s = [omega](1) which in turn implies that one can convert imperfect completeness to perfect in linear-sized PCPs for NTIME[0(n)] with a 0(log n) additive loss in the query complexity q. We show our result by constructing a "robust circuit" using threshold gates. These results are a gap amplification procedure for PCPs (when completeness is imperfect), analogous to questions studied in parallel repetition [21] and pseudorandomness [141. We also investigate the time complexity of approximating perfectly satisfiable instances of 3SAT versus those with imperfect completeness. We show that the Gap-ETH conjecture without perfect completeness is equivalent to Gap-ETH with perfect completeness; that is, MAX 3SAT(1 - [epsilon], 1 - [delta]) for [delta] > [epsilon] has 2⁰([superscript n])-time algorithms if and only if MAX 3SAT(1, 1 - [delta]) has 2⁰([superscript n])-time algorithms. We also relate the time complexities of these two problems in a more fine-grained way, to show that T₂ (n) by Nikhil Vyas.
S.M.
S.M. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
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Drucker, Andrew Donald. "PCPs for Arthur-Merlin games and communication protocols." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60160.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.Includes bibliographical references (p. 59-62).
Probabilistically Checkable Proofs (PCPs) are an important class of proof systems that have played a key role in computational complexity theory. In this thesis we study the power of PCPs in two new settings: Arthur-Merlin games and communication protocols. In the first part of the thesis, we give a 'PCP characterization' of AM analogous to the PCP Theorem for NP. Similar characterizations have been given for higher levels of the Polynomial Hierarchy, and for PSPACE; however, we suggest that the result for AM might be of particular significance for attempts to derandomnize this class. To test this notion, we pose some 'Randomized Optimization Hypotheses' related to our stochastic CSPs that (in light of our result) would imply collapse results for AM. Unfortunately, the hypotheses appear over-strong, and we present evidence against them. In the process we show that. if some language in NP is hard-on-average against circuits of size 2 [omega](n), en there exist hard-on-average optimization problems of a particularly elegant form. In the second part of the thesis, we study PCPs in the setting of communication protocols. Using techniques inspired by Dinur's proof of the PCP Theorem. we show that functions f (X, y) with nondeterministic circuits of size i have -distributed PCP protocols' of proof length O(poly(m)) in which each verifier looks at a constant number of proof positions. We show a complementary negative result: a distributed PCP protocol using a proof of length f, in which Alice and Bob look at k bits of the proof while exchanging t bits of communication, can be converted into a PCP-free randomized protocol with communication bounded by In both parts of the thesis, our proofs make use of a powerful form of PCPs known as Probabilistically Checkable Proofs of Proximity. and demonstrate their versatility. In our work on Arthur-Merlin games, we also use known results on randomness-efficient soundness- and hardness-amplification. In particular, we make essential use of the Impagliazzo-Wigderson generator; our analysis relies on a recent Chernoff-type theorem for expander walks.
by Andrew Donald Drucker.
S.M.
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Giese, Arnaud. "Régulation de la protéine centrale de la polarité planaire cellulaire Vangl2 dans l’organe de Corti." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21761/document.
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Outre leur polarité apico-basale, certaines cellules épithéliales développent une seconde polarité, appelée Polarité Planaire Cellulaire (PCP). L'axe de la PCP est orienté perpendiculairement à l'axe de polarité apico-basale et régit l'orientation uniforme de certaines structures, comme les poils ou cils, non seulement à l'échelle de la cellule mais également au sein du tissu. L'épithélium cochléaire est l'un des meilleurs modèles d'étude de PCP chez les mammifères. En effet, les cellules neuro-épitheliales qui le composent, soutenues par des cellules de soutien, présentent à leur apex, des touffes ciliaires dont l'orientation est parfaitement coordonnée par la voie de la polarité planaire. Les deux premiers gènes impliqués dans la PCP chez les mammifères, Vangl2 et Scrib1, ont été identifiés sur la base du phénotype de la cochlée chez les mutants. L'analyse de la localisation de Vangl2 dans l'organe de Corti a également révélé une localisation asymétrique proximo-distale et transitoire de la protéine, perpendiculaire à l'axe apico-basal classique. Cette asymétrie apparaît à la jonction entre deux types cellulaires : une cellule sensorielle ciliée et une cellule de soutien. J'ai pu montrer au cours de mes travaux de thèse que cette asymétrie était majoritairement due à une accumulation de Vangl2 du côté distal des cellules de soutien, et que dans une moindre mesure, Vangl2 pouvait ségréger du côté distal des cellules ciliées. Cette localisation subcellulaire très précise et limitée dans l'espace semble être indépendante de l'expression du gène Scrib1 dans les cellules ciliées. La délétion du gène Scrib1 dans les cellules ciliées m'a toutefois permis de mettre en évidence que ce gène avait un rôle autonome dans la régulation de la PCP, et que les cellules de soutien de l'organe de Corti pouvaient jouer un rôle prépondérant dans le contrôle de la PCP. Mes travaux ont également permis de mettre en évidence que GIPC1 avait un rôle dans la régulation de la PCP et le maintien de l'intégrité des touffes ciliaires des cellules sensorielles, et que le complexe GIPC1/Myosine VI pouvait réguler l'établissement de l'asymétrie de Vangl2 dans l'organe de CortiSeveral epithelia exhibit a second polarity perpendicular to the apico-basal axis, called planar polarity and that governs the orientation of structures such as stereocilia and hear. Our laboratory studies planar polarity, using mammalian cochlear sensory epithelium and we focus our studies on Vangl2, that we identified as the first mammalian planar polarity gene. Vangl2 encodes a four-transmembrane protein that contains a PDZ binding domain in its C-terminus tail. Vangl2 is asymmetrically located at the junction between mechanosensory hair cells and supporting cells, and this asymmetry appears important for planar cell polarity. I have shown in my thesis, using STED microscopy, that Vangl2 asymmetry is mainly due to an accumulation of Vangl2 to the distal side of supporting cells. I sought to dissect the molecular role of Vangl2 by analysing its trafficking within the cochlear epithelium. Deletion analysis shows that the last 12 amino acids, unlike its N-terminus tail are essential for Vangl2 endoplasmic reticulum sorting, its plasma membrane targeting and its function. Conditional mutant mice analysis show that Scrib1, which we have previously shown, interacts with Vangl2 through the PDZ binding domain of its C-terminal tail, is not the protein mediating this asymmetry. My work also highlight that GIPC1 had a role in the regulation of PCP and maintaining the integrity of hair bundles of sensory cells, and that the complex GIPC1/Myosin VI could regulate Vangl2 asymmetry in the organ of Corti
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Mohammad, Hani Ali Yasin. "Iridium-PCP pincer complexes C-H oxidative addition reactions and functionalisation = Iridium-PCP-Pincer-Komplexe /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965171310.
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Isalou, Mansour. "Sequential anaerobic-aerobic biodegradation of tetrachloroethene (PCE)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq35193.pdf.
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Sutherland, Ian George. "The effect of CFCs on PCE biodegradation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58672.pdf.
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Mattock, Edwina Dorothy. "Professional identities in transition : the perceptions of in-service trainee PCE teachers undertaking an initial PCE teacher-training course." Thesis, Open University, 2010. http://oro.open.ac.uk/54535/.
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A change in government policy and perception regarding the importance of the Post Compulsory Education (PCE) sector to the economy has led to an increase in the professionalisation of the sector as a whole. This in turn has led to changes in training for teachers who work in PCE - the latest of these changes took place in September 2007 and required all those working as teachers in the sector to acquire a licence to practice and work towards qualified teacher status (QTLS) through continuous professional development (CPD). This study focuses on in-service trainee teachers undertaking a PCE initial teacher-training course and explores the transition from trainee to professional teacher. Using participant produced drawings and stories, and follow-up interviews, trainee teachers voice their own interpretations and perceptions of teacher-training, teachers and teaching. In addition, interview data from four participants designated as experts (experienced teachers who were working, or had worked, on teacher-training programmes) were included to add insight into policy change from the teacher-educator viewpoint. The aim of this study was to highlight individual perceptions of a lived experience - how trainee teachers saw the role of teachers and experienced the teacher-training process. The acquisition of teaching qualifications was seen by the trainees in this study as an important progression in their professional development because they were an acknowledgement of professional competence. This was also seen as a necessary part of acquiring a teacher identity in that it raised the status of the trainees and recognised their professional approach to their practice. For some of the trainees accepting their capabilities to perform the teaching role was easier than accepting an identity change - they considered themselves to be works in progress. Data provided by the trainees also showed that personal qualities were as equally valuable in the development of a professional teacher an idea not given emphasis in the new teacher-training course.
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Ng, Hoi-lam Alam. "Characterization of cre expression in BAC-Pcp2-IRES-Cre transgenic mice." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B36278245.
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Ng, Hoi-lam Alam, and 吳凱琳. "Characterization of cre expression in BAC-Pcp2-IRES-Cre transgenic mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36278245.
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Fong, C. S. "The role of spindle pole body component Pcp1 in fission yeast." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19201/.
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The centrosomal pericentrin-related proteins play pivotal roles in various aspects of cell division, however their underlying mechanisms have remained largely elusive. Here we show that fission yeast Pcp1, a pericentrin-like protein, regulates multiple functions of the spindle pole body (SPB) by recruiting two crucial factors: γ-tubulin complex (γ-TuC) and polo kinase (Plo1). We isolated two temperature-sensitive pcp1 mutants, pcp1-15 and pcp1-18, that display similar abnormal spindles but with remarkably different molecular defects. pcp1-15 is defective in recruiting γ-TuC to the mitotic SPB, and crucially restoring γ-TuC localisation to the SPB suppresses the mutant. In contrast, pcp1-18 fails to recruit Plo1, which results in defects in mitosis-specific reorganisation of the nuclear envelope (NE) and consequently, impairment of SPB insertion into the NE. Strikingly, pcp1-18 is rescued by overproducing nuclear pore components or advancing mitotic onset. Consistent with these findings, Pcp1 forms a complex with both γ-TuC and Plo1 in the cell. Lastly, we also show that Pcp1 is phosphorylated by Plo1 during mitosis. Our results therefore verify Pcp1’s speculated role in γ-TuC-mediated spindle assembly and unveils its unanticipated function in Plo1-dependent mitotic entry and structural reorganisation of the NE. The central role of Pcp1 in orchestrating multiple SPB functions provides mechanistic insight into how centrosomes regulate multiple cellular pathways, and may be relevant to cancer development due to centrosomal aberrations.
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Katakam, Hruday chand. "Fabrication and Characterization of Polycarbonate Polyurethane (PCPU) Nanofibers Impregnated with Nanofillers." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5525.
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Polycarbonate polyurethane (PCPU) has been studied as a novel polymer impregnated with nanoparticles for improved mechanical, thermal and adhesion properties [4]. This study investigates the synthesis of polycarbonate polyurethane (PCPU) polymeric nanofiber membranes by the process of electrospinning. This study further examines all the parameters associated with electrospinning a novel PCPU polymeric solution impregnated with nanofillers, such as nanoparticles, to produce fiber membranes. Tetrahydrofuran (THF) and N, N dimethylformamide (DMF) are used as solvents to dissolve PCPU polymer. One percent (1%) of nanofillers like silver and silica nanoparticles are added to PCPU polymer solution to investigate the impact on polymer solution properties, which in turn affects the fiber formation. Process parameters are studied by evaluating the impact each parameter has on the fiber formation. PCPU polymer concentrations of three polymer solutions (PCPU, PCPU + 1% silver and PCPU + 1% silica) with the appropriate solvent mixture ratio are achieved to produce polymeric fiber membranes with minimal bead formation. Polymeric nanofiber membranes of PCPU, PCPU + 1% silver and PCPU + 1% silica are produced using THF/DMF: 70/30 (V/V) solvent mixture. The polymeric nanofiber membranes obtained are characterized by using a scanning electron microscopy, rotational viscometer, tensiometer, contact angle measurement device, fourier transform infrared spectroscopy (FTIR). A comparative life cycle assessment (LCA) is performed to evaluate environmental impacts associated with solvents in the process of producing PCPU polymeric nanofiber membranes. The LCA is completed to gauge the potential impacts PCPU nanofiber membranes may have when utilized for various applications.
This study discusses the successful production and characterization of good quality (no beading) polymeric nanofiber membranes of PCPU and novel composites of PCPU + 1% silver and PCPU + 1% silica. This two dimensional production of impregnated PCPU in nanofiber form will give researchers the opportunity to capitalize on the large surface areas of PCPU nanofibers versus PCPU thin films.
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Kubálek, Jan. "Vysokorychlostní paketové DMA přenosy do FPGA." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2020. http://www.nusl.cz/ntk/nusl-417262.
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This thesis deals on the design, implementation, testing and measuring of a firmware module for FPGA chips, which enables DMA transfers of network data from computer RAM to the FPGA chip placed on a network interface card. These transfers are carried out using a PCIe bus on the speed of up to 100 Gbps with the possible support of speeds 200 Gbps and 400 Gbps. The goal of this technology is to allow network data processing for the purpose of maintenance of backbone network nodes and data centers. The module is designed so it can be used on different types of FPGA chips, mainly those produced by companies Xilinx and Intel.
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Wang, Lei. "Tetrachloroethene (PCE) and trichloroethene (TCE) biogradation with bioreactors /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036865.
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Mohammad, Hani Ali Yasin. "Iridium-PCP-Pincer complexes - C-H oxidative addition reactions and functionalisationource Iridium-PCP-Pincer-Komplexe - oxidative C-H-Additionsreaktion und Funktionalisierung /." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10236374.
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Lugli, Elena. "Analysis of a multi-gene family, PRT1. encoding subtilism-like serine proteases in Pneumocystis carinii." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302531.
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Lee, Wai-ming. "Correlation of PCPT and SPT data from a shallow marine site investigation /." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30110385.
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Lee, Wai-ming, and 李慧明. "Correlation of PCPT and SPT data from a shallow marine site investigation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B44570077.
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Thomas, Sophie. "PCP4, trisomie 21 et maladies neurodégénératives : construction et étude de modèles murins." Paris 5, 2005. http://www.theses.fr/2005PA05N16S.
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La Trisomie 21 se caractérise par un tableau clinique complexe comprenant des anomalies morphologiques et un retard mental. Elle est associée à un vieillissement accéléré avec un vieillissement précoce d'une neuropathologie d'Alzheimer. PCP4 est localisé sur HSA21 et intervient dans la transduction du signal calcique, processus impliqué dans la construction des réseaux neuronaux, suggérant que certains signes de la trisomie 21 pourraient être associés à sa surexpression. L' analyse du profil d'expression de PCP4 au cours de l'embryogénèse murine a permis de démontrer qu'il apparaît précocement dans des structures participant à l'établissement des connexions neuronales ainsi que dans d'autres organes atteints chez les patients trisomiques 21. Au cours du vieillissement normal, PCP4 n'est pas modulé systématiquement suggérant que les modulations observées en cas de neurodégénérescence sont provoquées par les gènes impliqués dans ces pathologies. Afin de rechercher l'implication de ce gène dans la trisomie 21, nous avons construit un modèle murin transgénique par transfection du gène entier dans des cellules ESPCP4 (PEP-19) belongs to a family of Iq motif proteins involved in calcium transduction signals. It binds calmodulin and regulates CamKII and nNOS wich are involved in neuronal plasticity and wich may also mediate the transduction of apoptotic signal. The gene is localized on HSA21 and is in 3 copies in Down syndrome (DS) patients. To determine whether PCP4 may be involved in some DS phenotypic features, we analysed its expression pattern during mouse development and in the adult brain. PC expression pattern suggests that its overexpression may be involved in some of the DS features such as abnormalities in neuronal differentiation in cluding synaptogenesis and migration. We thus constructed a mouse model of PCP4 overexpression using the ES cells transgenesis method. The transgenicline is currently under study. PCP4 expression in the aging brain has been shown not to vary systematically during normal aging suggesting that PCP4 modulations in human neuropathologies are induced by genes involved in these diseases. Moreover, microarrays analysis suggests that PCP4 modulation is associated with other genes involved in neurotransmission
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Serinagaoglu, Yelda. "Analysis of Pcp-2/L7 gene expression and function." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180545753.
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Rectanus, Heather Veith. "Assessment of Intrinsic Bioremediation at a PCE Contaminated Site." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/35335.
Full textAbstract:
Groundwater parameter analysis, microcosm experiments, and microcosms
modeling were undertaken to assess the potential of Monitored Natural
Attenuation as a remediation strategy at Site 12 at the Naval Amphibious
Base (NAB) Little Creek. Site 12 was contaminated with PCE waste disposed
by a former dry cleaning facility. In the groundwater analysis, contaminant
characteristics and redox indicators were evaluated to assess the
reductive dechlorination potential of Site 12. The results of the
groundwater analysis indicated that Site 12 exhibited sulfate-reducing
and methanogenic conditions which provide the required environment
for reductive dechlorination. However, Site 12 only demonstrated partial
reductive dechlorination to cis-1,2-DCE and possible anaerobic oxidation
of cis-1,2-DCE and VC to CO_{2}. Microcosms were designed to further
evaluate the extent of microbial degradation of the chlorinated ethenes
at Site 12 and to provide concentration versus time data for the estimation
of chlorinated ethenes' biodegradation rates. The extent of degradation
in the microcosms was consistent with the groundwater data. However,
ethene production was not observed and the quantity of TCE measured
for two of the microcosms differed substantially when compared to
the groundwater data. The microcosm model used SEAM3D to simulate
the results of the microcosm experiments (concentration versus time
data) to estimate the biodegradation rates of PCE and its daughter
products. The SEAM3D reductive dechlorination package, based on Monod
kinetics, predicted for the MLS12-Shallow microcosm maximum specific
utilization rates for PCE, TCE, cis-1,2-DCE and VC at 0.4, 0.42, 0.05,
and 0.25 day^{-1}, respectively and half saturation coefficients for
PCE, TCE, cis-1,2-DCE and VC at 0.41, 0.01, 0.07, and 0.02 mg/L, respectively.
The results of this study suggest that while the groundwater environment
provides the necessary conditions for reductive dechlorination, Site
12 is not an efficient system for reductive dechlorination. This lack
of efficiency may stem from sparse microbial populations capable of
reducing cis-1,2-DCE or the system may contain levels of PCE which
inhibit the further reduction of cis-1,2-DCE. Based on the observed
inhibitory relationship between PCE and cis-1,2-DCE and VC production,
source removal would reduce the PCE levels and encourage further reductive
dechlorination at Site 12. Therefore, the recommended first step for
a monitered natural attenuation-based remediation strategy at Site
12 should be source removal.Master of Science
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Beaudet, France. "Abiotic treatment of PCP-contaminated water with metallic iron." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6639.
Full textAbstract:
The removal of PCP from aqueous solution in contact with metallic iron was investigated by laboratory batch experiments. The decline in PCP concentration as well as inorganic parameters were monitored over time. Removal of up to 90% of the initial PCP was observed within 24 hours. The initial geochemical conditions of the PCP solution changed rapidly to basic and reductive conditions when in contact with metallic iron. Organic degradation by-products were not found during the removal of PCP using two distinct analytical procedures. Chloride ions analyzed in the solution after PCP removal were relatively low and showed high variability between experiments. The extraction of iron with solvents showed that a maximum of 37% PCP was sorbed. The effectiveness of iron on PCP removal appeared to be limited by the number of contacts with a fresh PCP solution. The rate constant in PCP removal appeared to be directly proportional to the iron to solution ratio. The PCP removal behaviour fitted well two sorption models (Freunlich, Langmuir). The results indicate that the process involved in the removal of PCP does not seem to be dechlorination because of the lack of by-products and low level in chloride ion, and is not completely sorption because of the lack of reversibility.
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Kadric, Edin. "An FPGA implementation for a high-speed optical link with a PCIe interface." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106491.
Full textAbstract:
This thesis describes the design and implementation of an optical fiber based high speed interface between two computers. The system is particular in that the data transits in a Field Programmable Gate Array (FPGA) situated between each computer and the optical fiber link. The measured full duplex speed for exchanging data between two C programs running on two different computers is over 8Gbit/s, including encoding, protocol and software overhead. This design is suited for applications requiring high bandwidth between two computers, and since an FPGA sees all the data being exchanged, it can be used as a fast and flexible data processing tool: Error correction, debug support, data analysis, encryption and compression are all possible uses where the FPGA can save the Central Processing Unit (CPU) an important amount of computing cycles.Cette thèse décrit la conception et l'implémentation d'une interface à grande vitesse entre deux ordinateurs, basée sur un lien en fibre optique. La particularité du système est que les données transitent dans un "Field Programmable Gate Array" (FPGA) qui se trouve entre chaque ordinateur et les câbles en fibre optique. La vitesse de transmission bidirectionnelle de données d'un programme en C à un autre via cette interface a été mesurée à plus de 8Gbit/s. Ceci inclus les ralentissements dus à l'encodage, le protocole de communication et le logiciel. Cette conception convient à des applications demandant une bande passante importante entre deux ordinateurs, et comme un FPGA observe toutes les données échangées, ce dernier peut être utilisé comme un outil de traitement de données rapide et flexible: La correction d'erreur de transmission, le support de débogage, l'analyse, le chiffrement et la compression de données sont toutes des applications potentielles où le FPGA peut alléger la tâche de l'unité centrale.
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Iscru, Emilia Maria. "Electrophysiological characterization of the cerebellar Purkinje cells from the Pcp2-L7- deficient mice." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1213299492.
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Mouton-Liger, François. "Fonction, régulation de PCP4 et trisomie 21 : analyse de modèles murins de surexpression." Paris 7, 2008. http://www.theses.fr/2008PA077062.
Full textAbstract:
La Trisomie 21 est la plus fréquente anomalie chromosomique et se caractérise par un tableau clinique complexe avec notamment un retard mental constant. Les déficiences cognitives dont l'origine demeure mal connue, pourraient être la conséquence d'altérations du développement précoce du système nerveux. PCP4/PEP-19 (Purkinje Cell Protein 4) est une protéine, dont le gène est localisé sur le chromosome 21, impliquée dans la transduction du signal calcique et modulant l'activation des cibles du complexe Ca2+-Calmoduline, dont la CaMKII. PCP4 possède une expression précoce dans le neuroectoderme, suggérant un rôle dans le développement des différentes structures du système nerveux. Pour confirmer cette hypothèse, un modèle de surexpression de PCP4 a été construit par transgénèse : les souris TgPCP4. Notre étude à plusieurs stades de développement, au niveau du transcrit et de la protéine, montre chez les TgPCP4 la présence de PCP4 dans des régions du système nerveux, où il est normalement observé plus tard au cours de l'embryogenèse. L'analyse par des marqueurs de différenciation neuronale montre que la surexpression de PCP4 induit une maturation neuronale précoce au niveau des ganglions nerveux et du rhombencéphale. Dans ces régions, nous avons mis en évidence une modulation de l'activité de la CaMKIIô, suggérant son implication dans ce mécanisme. Des résultats similaires ont été obtenus sur les souris TslCje, trisomiques pour une région du chromosome 16 murin orthologues du 21 humain pour 85 gènes (dont pcp4\ indiquant que les conséquences de cette surexpression peuvent être maintenues dans le contexte multigénique de la Trisomie 21Pcp4/pepl9 is a modulator of Ca2+-CaM, a key molecule for calcium signaling, expressed in postmitotic neuroectoderm cells during mouse embryogenesis. PCP4 gene is located on human chromosome 21, and present in three copies in Down syndrome (DS). To evaluate the consequences of 3 copies of this gene on the development of these cells in the nervous System, we constructed a transgenic (TgPCP4) mouse model, with one copy of human PCP4, and investigated the effects in this model. We showed that pcp4 overexpression is present at transcript and protein levels, and overexpression induced precocious neuronal differentiation, as shown by the distribution and levels of early neuronal markers. We also demonstrated that pcp4 overexpression was associated with an increase in CaMKIIdelta activation, TgPCP4 and TslCje, a mouse model of DS, developed similar modifications, demonstrating that these mechanisms may account for abnormal neuronal development in DS
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Iscru, Emilia. "Electrophysiological characterization of the cerebellar Purkinje cells from the Pcp2-L7- deficient mice." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213299492.
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Burghardt, Julie Marie. "Laboratory study evaluating thermal remediation of tetrachloroethylene impacted soil." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/967.
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Vigraham, Sushrutha. "Design and Analysis of a Real-time Data Monitoring Prototype for the LWA Radio Telescope." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/31306.
Full textAbstract:
Increasing computing power has been helping researchers understand many complex scientific problems. Scientific computing helps to model and visualize complex processes such as molecular modelling, medical imaging, astrophysics and space exploration by processing large set of data streams collected through sensors or cameras. This produces a massive amount of data which consume a large amount of processing and storage resources. Monitoring the data streams and filtering unwanted information will enable efficient use of the available resources. This thesis proposes a data-centric system that can monitor high-speed data streams in real-time. The proposed system provides a flexible environment where users can plug-in application-specific data monitoring algorithms. The Long Wavelength Array telescope (LWA) is an astronomical apparatus that works with high speed data streams, and the proposed data-centric platform is developed to evaluate FPGAs to implement data monitoring algorithms in LWA. The throughput of the data-centric system has been modeled and it is observed that the developed data-centric system can deliver a maximum throughput of 164 MB/s.Master of Science
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Matos, Gutiérrez Jaime Aquiles. "Optimización de la producción por sistema PCP en campo Pacaya." Universidad Nacional de Ingeniería. Programa Cybertesis PERÚ, 2009. http://cybertesis.uni.edu.pe/uni/2009/matos_gj/html/index-frames.html.
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Dennis, Philip Christopher. "Community analysis of an anaerobic tetrachloroethene, PCE, degrading bacterial consortium." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/MQ53371.pdf.
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Brown, Andrea J. "Endogenous decay sustaining PCE degradation and associated stable isotope effects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0018/MQ53370.pdf.
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Reynolds, Timothy James. "PCP pincer compounds: synthesis and application as methanol carbonylation catalysts." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654115.
Full textAbstract:
A range of 1,8-bis(PR2)anthracene - " Anthraphos " - compounds have been synthesised. Previously reported (where PR2 = -PPh2 (2.1) or -Pi-Pr2 (2.5)), and new (where PR2 = -PCYP2 (2.18), -PCyh2 (2.19) -Po-Tol2 (2.20) or -Po-Ans2 (2.21)) anthraphos structures have been prepared in 3 steps starting from 1,8-dichloroanthraquinone (2.7). Compound (2.7) was converted by chlorine- bromine substitution followed by reduction with Al(OCyhh into 1,8-dibromoanthracene (2.4), from which (2.1), (2.5) and (2.18)-(2.21) were prepared by double lithiation of (2.4) with n-BuLi and subsequent reaction with the corresponding ClPR2 reagent. 1,8-bis(di-tert-butylphosphino)anthracene (2.6) was prepared according to the literature procedure in 3 steps starting from 1,8-dichloroanthraquinone (2.7). On reaction of (2.5), (2.18) or (2.19) with [NiCl2(dme)l or [PtCl2(t-BuCNhl in the presence of i-Pr2NEt, cyclometallation of the C-H bond in the anthracene C(10)-position led to the new square-planar nickel and platinum pincer complexes (3.1)-(3.3) and (3.7)( 3.9), respectively. Reaction of (2.5), (2.18) or (2.19) with [PdCl2(CH3CNhl afforded the analogous new palladium pincer complexes (3.4)-(3.6) in the absence of i-Pr2NEt. On reaction of (2.5), (2.6), (2.18) or (2.19) with 0.5 eq. of [RhCl(COEhb cyclometallation of the C-H bond at the anthracene C(lO) position gave the corresponding new 5- coordinate Rh(llI) pincer complexes (3.10)-(3.13). Exposing solutions of (3.10)-(3.12) to CO gas led to coordination of CO, affording the 6-coordinate pseudooctahedral Rh (Ill) pincer complexes (3.14)-(3.16). Complexes (3.14)-(3.16) were also prepared by reaction of the diphosphines (2.5), (2.18) or (2.19) with 0.5 eq. of [RhCl(COhb at room temperature. Exposing a C6H6 solution of (2.6) to CO afforded the Rh(I) square-planar pincer complex (3.20) with elimination of HCl. Square-planar Rh (I) carbonyl pincer complexes (3.17)-(3.19) were prepared by dehydrochlorination of (3.14)-(3.16) with i-Pr2NEt at RT. The analogous complexes of diphosphines (2.20) and (2.21) were prepared by reaction of the diphosphines with 0.5 equivalents of [RhCl(CO)2b in the presence of i-Pr2NEt. 5-coordinate Ir(Ill) pincer complexes (3.25) and (3.26) were prepared under similar conditions to those in the literature, and the new complex (3.27) by reaction of (2.19) with 0.5 eq. of [IrCl(COEhb. Rh(I) complexes (3.17)-(3.19), (3.21) and (3.22) oxidatively add MeI at room temperature and subsequently undergo migratory insertion to give the corresponding 5-coordinate Rh(IH) acetyl species. Complex (3.20), with bulky tBu2P-substituents, was unreactive towards MeI under the same conditions. Kinetic studies with (3.17)-(3.19) and (3.21) and (3.22) showed that the second-order rate constants (kl ) for MeI oxidative addition varied by a factor of >850, depending on the structure of the diphosphine. Complex (3.22), with o-anisyl P-substituents, showed a second-order rate constant of 90.2 M-I S-1 (CH2Cl2, 23 CC) compared to 0.106-0.408 M-I S-1 for (3.17)-(3.19) and (3.21). The rate enhancement is . proposed to be due to neighbouring group participation of the methoxy groups. Rh(I) complexes (3.17)-(3.19) and (3.22) were used as pre-catalysts for HI-promoted methanol carbonylation under industrially relevant conditions, using CO and CO /H2 (95:5) as feed gasses. 31p{IH} NMR spectra of the exit solutions suggested the phosphines remained largely bound to the metal centres at the end of the reactions. Using pincer compounds as pre-catalysts, carbonylation rates over twice that of the Monsanto catalyst ([Rh(COhI2t) were observed using CO feed gas, and approaching 3 times using CO/H2. A mechanism for the formation of acetic acid and side-products from MeOH and CO catalysed by pincer compounds is proposed .
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Veeman, Michael Terrence. "Zebrafish prickle : non-canonical Wnt/PCP functions in vertebrate gastrulation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/4999.
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González, Morales Nicanor. "L'intestin adulte comme modèle d'étude de l'asymétrie droite-gauche chez la Drosophile : couplage entre la myosine ID et la polarité planaire dans l'asymétrie droite-gauche chez la Drosophile." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4071/document.
Full textAbstract:
L’asymétrie Droite-Gauche (DG) est responsable de l’empaquetage et l’enroulement stéréotypé des organes internes au cours du développement. Chez la Drosophile, l’intestin postérieur adulte (AHG) se développe asymétriquement selon l’axe DG en formant une boucle dextrale. Comme pour tous les organes asymétriques DG de la Drosophile, la mise en place de l’axe DG nécessite l’expression de la myosine non conventionnelle de type I : MyoID. Cette myosine se lie à la DE-Cadherine au niveau des jonctions adhérentes (AJ) pour mettre en place l’axe DG, mais le mécanisme moléculaire qui transforme la chiralité de MyoID en une morphogenèse asymétrique DG est totalement inconnu. Le AHG est un long tube situé au milieu de l’abdomen, qui présente une boucle dextrale dans sa partie proximale. Il se développe à partir d’un groupe de progéniteurs formés de deux populations de cellules : H1 et H2. Dans cette étude, nous avons mis en évidence que MyoID contrôle la formation de la boucle dextrale du AHG grâce à son interaction avec la cadhérine atypique Dachsous dans les cellules H1. De plus, nous avons pu mettre en évidence que la signalisation Dachsous-Fat est activée à travers les cellules H2 entrainant leur polarisation du coté droit, et ainsi formant l’enroulement du AHG. Les cellules H1 sont transitoires, elles disparaissent lors des premières heures de la métamorphose. Cependant, l’information dextrale générée dans les cellules H1 perdure dans les cellules H2 grâce à l’action coordonnée des composants de la polarité planaire. Nous montrons que la polarité planaire contrôle l’établissement de l’asymétrie DG en aval de MyoID, en transmettant l’information DG dans le AHGStereotyped left right (LR) asymmetry ensures proper looping of internal organs. In Drosophila, the adult hindgut (AHG) has a clear stereotypical dextral loop and, like all LR asymmetric organs, require MyoID for correct orientation. MyoID is an unconventional myosin type I that binds to DE-Cadherin, this association is required for proper LR establishment; however the mechanism that translates MyoID chirality into proper morphogenesis remains unknown. The AHG is a long tube coiled dextrally and located in the middle of the abdominal region. It develops from a cluster of progenitors containing two different populations of cells, H1 and H2. Here, we show that MyoID controls the AHG dextral loop by binding to the atypical cadherin Dachsous in H1 cells. Further, Ds-Fat signaling propagates towards the H2 cells which in turn become polarized towards the right and consequently loop. H1 is a transient population of cells that wear off in the first hours of metamorphosis; nevertheless the dextral information generated in H1 is maintained in H2 cells due to the cooperative action of PCP components. We demonstrate that the molecular basis of the LR establishment downstream of MyoID action lies in the PCP system, which has a double role transmitting and maintaining a dextral signal in the AHG. Thus, we provide for the first time a link in L/R morphogenesis between Drosophila and vertebrates in which PCP mutants result in L/R defects. Furthermore, in our attempts to better understand the evolution of L/R morphogenesis we found the recently co-Appearance of a myoID cis-Regulatory element and the AHG dextral loop, during Drosophila evolution, suggesting that changes in myoID express
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Mittenzwey, Nico. "Evaluating and Improving the Performance of MPI-Allreduce on QLogic HTX/PCIe InifiniBand HCA." Master's thesis, Universitätsbibliothek Chemnitz, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200901053.
Full textAbstract:
This thesis analysed the QLogic InfiniPath QLE7140 HCA and its onload architecture
and compared the results to the Mellanox InfiniHost III Lx HCA which uses an offload
architecture. As expected, the QLogic InfiniPath QLE7140 HCA can outperform the
Mellanox InfiniHost III Lx HCA in latency and bandwidth terms on our test system in
various test scenarios. The benchmarks showed, that sending messages with multiple
threads in parallel can increase the bandwidth greatly while bi-directional sends cut
the effective bandwidth for one HCA by up to 30%.
Different all-reduce algorithms where evaluated and compared with the help of the
LogGP model. The comparison showed that new all-reduce algorithms can outperform the ones already implemented in Open MPI for different scenarios.
The thesis also demonstrated, that one can implement multicast algorithms for InfiniBand
easily by using the RDMA-CM API.
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Hofmann, Eckhard. "Strukturanalyse der Lichtsammler Peridinin-Chlorophyll Alpha-Proteine (PCPs) von Amphidinium carterae und Heterocapsa pygmaea /." [S.l. : s.n.], 1999. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8312568.
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Martinez, Sébastien. "Rôle de la protéine tyrosine kinase 7 dans le cancer colorectal et la polarité planaire cellulaire." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4019.
Full textAbstract:
La voie de signalisation WNT/PCP, couramment associée à la polarité planaire cellulaire, joue un rôle fondamental dans la morphogenèse chez les vertébrés. Parmi les différents composants protéiques de la voie WNT/PCP, on retrouve la protéine tyrosine kinase 7 (PTK7), dont les fonctions restent encore très peu décrites. Au cours de ma thèse, j’ai montré que PTK7 interagissait avec le récepteur tyrosine kinase ROR2. Ce complexe, après fixation du ligand WNT5A, induit la migration de fibroblastes embryonnaires murins via l’activation de JNK. Au cours du développement embryonnaire du xénope, Ptk7 interagit de manière fonctionnelle avec Ror2, et contrôle l’expression de la protocadhérine Papc ainsi que la morphogénèse. De plus, en utilisant une approche de Tissue MicroArray, réalisée sur des patients atteints de cancers colorectaux, j’ai pu montrer que PTK7 était retrouvé surexprimé chez 34% des patients, et que cette surexpression était un facteur de mauvais pronostic. Dans des lignées cellulaires issues de cancers colorectaux, la suppression de PTK7 par shRNA entraine une diminution de la migration des cellules tumorales, mais n’impacte pas leur prolifération et leur résistance aux drogues anticancéreuses. Dans un modèle de xénogreffe murin, la suppression de PTK7 induit une diminution du développement tumoral et l’expression de ce dernier, dans des cellules négative pour PTK7, entraine une augmentation de l’apparition de métastases chez les animaux injectés. Ce travail apporte de nouveaux éclaircissements sur le du récepteur PTK7 dans la voie de signalisation WNT/PCP, et le définit comme potentiel biomarqueur et cible thérapeutique dans le cancer colorectalThe non-canonical WNT/planar cell polarity (WNT/PCP) pathway plays important roles in morphogenetic processes in vertebrates. Among WNT/PCP components, protein tyrosine kinase 7 (PTK7) is a tyrosine kinase receptor with poorly defined functions lacking catalytic activity. We show that PTK7 associates with receptor tyrosine kinase-like orphan receptor 2 (ROR2) to form a heterodimeric complex in mammalian cells and physically and functionally interact with the non-canonical WNT5A ligand, leading to JNK activation and cell movements. In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to regulate protocadherin papc expression and morphogenesis. Furthermore, we show that Ptk7 is required for papc activation induced by Wnt5a and that Wnt5a stimulates the release of the Ptk7 intracellular domain, which can translocate into the nucleus and activate papc expression. Moreover, using a Tissue MicroArray produced from CRC patients we correlated PTK7 expression with pathological features and patient outcome. PTK7 was significantly up-regulated in CRC tissue, and its overexpression was found in 34% of patients. In CRC cell lines, shRNA PTK7 reduced migration, but did not affect cell proliferation and resistance to drugs. In a xenograft mouse model, downregulation of PTK7 led to reduced tumor growth, whereas its overexpression in PTK7-negative cancer cells led to increased metastatic events. This work reveals novel molecular mechanisms of action of PTK7 in non-canonical WNT/PCP signaling that may promote cell and tissue movements and define PTK7 expression as a potential prognostic biomarker and a novel therapeutic target in CRC
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Watson, Julia Alice. "Investigating the role of Wnt/Planar cell polarity (PCP) in Neuromesodermal Progenitors (NMPs)." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31193.
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Neuromesodermal progenitors (NMPs) are bipotent progenitors, located at the caudal end of the embryo and are essential for axis formation. These stem cell-like progenitors possess the ability to self-renew and differentiate to both mesodermal and neural lineages, such as skeletal muscle and spinal cord derivatives. These progenitors arise at E8.5 and are localised in the caudal lateral epiblast (CLE), a posterior region of the embryo near the primitive streak. Later in development, they reside in the tail bud until cessation of axial elongation at E13.5. Throughout these stages NMPs are characteristically marked by co-expression of T(Bra) (Brachyury) and Sox2. This characteristic is also present in in vitro NMPs, which can be derived from Epiblast Stem Cells (EpiSCs) through treatment with Wnt/β-catenin signalling agonists and Fgf2, which simulates their in vivo environment. Protein and mRNA profiling of NMPs and mutant phenotypes in vivo supports the hypothesis that a non-canonical Wnt pathway, the Wnt/Planar Cell Polarity pathway (PCP) could be involved in NMP fate decision and/or maintenance. This thesis focuses on understanding more about the role of PCP by aiming to identify the spatio-temporal profile of Wnt/PCP pathway components in NMP regions during axial elongation, as well as determining its role in NMP behaviour through manipulation of this pathway via in vivo and in vitro assays Employing in situ hybridisation and immunohistochemistry techniques, key Wnt/PCP components, including Pk1, Vangl2 and Ptk7, were confirmed to be present in in vivo and in vitro NMPs, thus, providing strong evidence that Wnt/PCP may be involved regulating NMP behaviour. Disruption of Wnt/PCP signalling through overexpression of Wnt/PCP components was tested in refined in vivo and in vitro assays. Overexpression of Vangl2 and Ptk7, but not Pk1 in NMPs regions in vivo resulted in loss of contribution to neural lineages, as well as lower contribution to NMP regions themselves. Similarly, Wnt/PCP components were disrupted in vitro through generation of dox-inducible overexpression cells lines for Wnt/PCP components. These lines were used to generate NMPs from an optimised novel alternative source Epiblast-Like Cells (EpiLCs), however no clear affect to lineage was observed. Overall this work has successfully advanced our knowledge of Wnt/PCP mediated control of NMP differentiation and maintenance, and provided a finer grained description of the relationships between them.
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Albers, Katja [Verfasser]. "Effiziente Parametrisierung der PCP-SAFT Zustandsgleichung auf minimaler Datenbasis / Katja Albers." München : Verlag Dr. Hut, 2012. http://d-nb.info/1028785933/34.
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Audet, Marie-Claude. "Effets comportementaux et cognitifs de la phencyclidine (PCP) chez le rat." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ56386.pdf.
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Ohandja, Dieudonne Guy. "Biodegradation of perchloroethylene (PCE) in a membrane aerated biofilm reactor (MABR)." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420530.
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Wingett, S. W. "The role of PCP-A class proteins in pollen-stigma interactions." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270620.
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Kent, Mark Alexander. "Cobalt PCP pincer and rhodium diphosphine complexes as methanol homologation catalysts." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566818.
Full textAbstract:
The first two examples of cobalt phosphine PCP pincer complexes, [Co{2,6- (CH2PPh2-KPhC6H3-K[1}(COh] and [Co{2,6-(CH2PPh2-KPhC6H3-KC1}(PMe3h] have been synthesised from the precursors [CoCl(PMe3)3] and [CO(CH3) (PMe3)4]. Both pincer complexes possess pseudo-trigonal bipyramidal geometry with the coordinating pincer P atoms in equatorial sites and the pincer C atom in an axial site. A route to these pincer complexes has been discovered which involves a rearrangement with loss of PMe3 from the cyclometallated complex [Co{2-(CH2PPh2-KP)-4-(CH2PPh2)C6H3-K[1}(PMe3)3]. The mechanism for this rearrangement has been probed by both kinetic studies and deuterium-labelling studies, which suggests that two mechanisms operate, one of which involves a series of intramolecular C-H oxidative additions and reductive eliminations to effectively 'shuttle' protons around the complex. The other mechanism is suggested to involve a proton source, which may be the solvent, THF. The preparation of some rare examples of cobalt phosphinite PCP pincer complexes based on the diphosphinites 1,3-bis(diphenylphosphinooxy)benzene and 1,3-bis(diphenylphosphinooxy)-4,6-(di-tert-butyl)benzene is also reported. The synthesis of these pincers proceeds via an isolated cobalt(III) pincer complex with hydride, chloride and PMe3 ancillary ligands. The subsequent reduction to cobalt(l) pincer complexes proceeds using NEt3 or LiAlH4 as reducing agents. The new propane-backboned diphosphines 1,3-bis(SH-benzo[b ]phosphindol-S- yl)propane and 1,3-bis(di-2-naphthylphosphino)propane were synthesised. These diphosphines were complexed with [{RhCl(COh}Z] to afford the corresponding dinuclear 12-membered metallacycles [{RhCl(CO)(Il-diphosphine)}2], the latter of which possesses two rotational isomers which involves the exchange of the positions of one Cl and one CO ligand. The diphosphines 1,3-bis(SH- benzo [b] phosphindol-S-yl) propane and o-di phenyl phosphino benzyldi phenyl- phosphine were complexed with [Rh(CODh]BF4 to afford cis-chelating mononuclear Rh(l) complexes. The application of these phosphines and complexes as catalysts for methanol reductive carbonylation and homologation has been investigated. The catalyst involving the tetrahydrochloride salt of 1,3-bis( di-2-pyridylphosphino )propane exhibits methanol reductive carbonylatiori/homologation selectivity superior to the best previously reported literature system. Also, the catalyst involving the diphosphine 1,3-bis(SH-benzo[b ]phosphindol-S-yl)propane exhibits promising stability and selectivity to acetic acid under reductive carbonylation conditions, signalling a potential application as a methanol carbonylation catalyst.
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Guruswami, Venkatesan 1976. "Query-efficient checking of proofs and improved PCP characterizations of NP." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/80084.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1999.Includes bibliographical references (leaves 70-73).
by Venkatesan Guruswami.
S.M.
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King, J. M. H. "Effect of pentachlorophenol on the microbial ecosystem of activated sludge." Thesis, University of York, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379496.
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