Relevant bibliographies by topics / PcTF

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Academic literature on the topic 'PcTF'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "PcTF"

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Bhunia, Asamanjoy, Dolores Esquivel, Subarna Dey, Ricardo Fernández-Terán, Yasutomo Goto, Shinji Inagaki, Pascal Van Der Voort, and Christoph Janiak. "A photoluminescent covalent triazine framework: CO2 adsorption, light-driven hydrogen evolution and sensing of nitroaromatics." Journal of Materials Chemistry A 4, no. 35 (2016): 13450–57. http://dx.doi.org/10.1039/c6ta04623a.

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Perera, Clifford, Udayangani Ramadasa, Chandrika Wijeratne, Panduka Karunanayake, Thashi Chang, Gamini Pathirana, Ravini Karunathilake, Suraj Perera, Kalyani Guruge, and Sankha Randenikumara. "Establishment of Palliative and End-of-Life Care Services in Sri Lanka." Prehospital and Disaster Medicine 34, s1 (May 2019): s127—s128. http://dx.doi.org/10.1017/s1049023x19002760.

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Introduction:Sri Lanka has a rapidly aging population with an exponential rise in chronic morbidity. There had been no parallel development of palliative and end-of-life care-specific approach in health care.Aim:To implement sustainable palliative and end-of-life care services in Sri Lanka through the existing systems and resources by advocacy, collaboration, and professional commitment.Methods:Sri Lanka Medical Association established a volunteer task force for palliative and end-of-life care (PCTF) in October 2016, which comprised of multi-disciplinary health care professionals, legal fraternity, and civil society. PCTF identified the need for sensitizing the general public on the importance of palliative care, for standard guidelines and formal training for practicing health care professionals engaged in hospital and community-based palliative care. These needs are addressed through activities of PCTF in collaboration with the Ministry of Health.Results:Representing the National Steering Committee of Palliative Care, the members of the PCTF were instrumental in developing the National Strategic Framework to fill the major gap of affordable quality palliative care in the country. PCTF also published the “Palliative Care Manual for Management of Non-Cancer Patients” as a preliminary guide for health care professionals. The draft document on the End-of-Life Care Guidelines has been formulated and is currently being reviewed by the relevant medical and legal stakeholders. PCTF has organized CME lectures on palliative care all over the country for health care professionals, and also conducted lectures, exhibitions, and mass media programs to sensitize the public on palliative care.Discussion:Within a brief period, PCTF has played a key role to recognize palliative care by contributing to policy making, training, and public sensitization in palliative and end-of-life care in Sri Lanka.
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Frank, Joachim. "New challenges to image processing posed by cryo-Electron microscopy of single particles." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 422–23. http://dx.doi.org/10.1017/s0424820100086416.

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Compared with images of negatively stained single particle specimens, those obtained by cryo-electron microscopy have the following new features: (a) higher “signal” variability due to a higher variability of particle orientation; (b) reduced signal/noise ratio (S/N); (c) virtual absence of low-spatial-frequency information related to elastic scattering, due to the properties of the phase contrast transfer function (PCTF); and (d) reduced resolution due to the efforts of the microscopist to boost the PCTF at low spatial frequencies, in his attempt to obtain recognizable particle images.
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Gu, Chunyang, Deyu Liu, Wei Huang, Jie Liu, and Renqiang Yang. "Synthesis of covalent triazine-based frameworks with high CO2 adsorption and selectivity." Polymer Chemistry 6, no. 42 (2015): 7410–17. http://dx.doi.org/10.1039/c5py01090j.

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de Jong, A. F., W. M. J. Coene, and A. J. Koster. "Measurement of PCTF parameters with high accuracy." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 1 (August 1992): 136–37. http://dx.doi.org/10.1017/s0424820100121089.

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Measurement of electron-optical parameters in TEM is important for two reasons: a) for automatic correction of focus, astigmatism and beam-tilt misalignment (autotuning) and b) for the accurate determination of the phase-contrast transfer function (PCTF) which is needed for a correct interpretation of high-resolution electron microscopy (HREM) images. This paper addresses specifically methods adapted to reach the second goal, stressing accuracy rather than speed and robusteness.
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Hosokawa, F., T. Osuna, M. Suzuki, and T. Oikawa. "Determination of Intensity Distribution of Effective Source by Means of PIXsysTEM." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 1 (August 12, 1990): 72–73. http://dx.doi.org/10.1017/s0424820100179117.

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The resolution of the transmission electron microscope is discussed considering its phase contrast transfer function (PCTF). Usually, as the envelope function for PCTF, the defocus due to the chromatic aberration (ED) and the reduction of the interference (EJ) due to the incidence angle of the electron beam upon the specimen are considered. It was shown by Frank that the latter is given by the Fourier transformation of the effective source. In the present study, the author shows that EJ can be calculated from the intensity distribution of a filament image formed near the back focal plane of the objective lens. This means that we can virtually get the profile of the effective source without focusing the exact back focal plane on the fluorescent screen, in the diffraction mood. Using the PIXsysTEM, the author also investigated the profile function of the effective electron source and calculated EJ values under various illumination conditions.Assume that the specimen is thin enough to be approximated as a weak phase object. In Fig. 1, consider A and B as filament images formed near the back focal plane of the objective lens by transmitted wave and scattered wave, respectively. They act as emitting sources for the image plane.
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Probst, W., E. Zellmann, G. Benner, and E. Weimer. "Cryo imaging using an energy-filtering TEM (EFTEM): Optimum use of phase-contrast transfer function (PCTF)." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 506–7. http://dx.doi.org/10.1017/s0424820100170268.

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Lack of contrast is one of the numerous problems arising from imaging of vitrified biological macromolecules in a TEM. This is due to the similar density of biological material and of vitreous ice and to the high background of inelastic scattering in the ice which is about four times that of carbon.Consequently in a CTEM images have to be recorded 1-3 μm underfocus to maximise phase contrast which in the same sense decreases the reliability of density information.Elastic filtering using an (EFTEM) allows closer to focus imaging still achieving considerable contrast. For 3D reconstruction of molecular densities the largest source of error is likely to arise from contributions of the PCTF. Thus, such images have to be corrected for the PCTF, which is much morereliably done for elastically filtered images close to focus.Thin vitreous ice films containing the virus particles were prepared on holey carbon grids and examined with cryo EM procedures. Images of frozen-hydrated cucumber mosaic virus (CCMV) particles ( Ø of roughly 25 nm) were recorded in Elastic Brightfield mode using the Zeiss EM 912 OMEGA with integrated imaging spectrometer and Koehler Illumination. Magnification was 50.000x, HT 120 kV, energy width 7 eV, total dose 800 electrons /nm2.
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Kim, Hye-Eun, Maiko Shitashiro, Akio Kuroda, Noboru Takiguchi, Hisao Ohtake, and Junichi Kato. "Identification and Characterization of the Chemotactic Transducer in Pseudomonas aeruginosa PAO1 for Positive Chemotaxis to Trichloroethylene." Journal of Bacteriology 188, no. 18 (September 15, 2006): 6700–6702. http://dx.doi.org/10.1128/jb.00584-06.

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ABSTRACT Pseudomonas aeruginosa PAO1 is repelled by trichloroethylene (TCE), and the methyl-accepting chemotaxis proteins PctA, PctB, and PctC serve as the major chemoreceptors for negative chemotaxis to TCE. In this study, we found that the pctABC triple mutant of P. aeruginosa PAO1 was attracted by TCE. Chemotaxis assays of a set of mutants containing deletions in 26 potential mcp genes revealed that mcpA (PA0180) is the chemoreceptor for positive chemotaxis to TCE. McpA also detects tetrachloroethylene and dichloroethylene isomers as attractants.
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Hosokawa, F., T. Tomita, T. Honda, and M. Kersker. "Ultra-High Resolution with The Jem-2010F Field-Emission Tem." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 464–65. http://dx.doi.org/10.1017/s0424820100164787.

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Historically, high probe current in small probes has been the principal virtue of the field emission TEM. Analytical performance is greatly enhanced[1] and fine probe mapping an important analytical tool for trace element segregation and very fine scale high resolution chemical imaging. Less appreciated is the enhanced high resolution capability due to the small energy spread of the electron source and higher coherency due to reduced primary and virtual source size. The envelope function of the phase contrast transfer function (PCTF) is drastically improved reducing image blurring due to both chromatic aberration and specimen illumination angle. This is especially true for the high spatial frequencies beyond the first zero. Intensities sufficient for image formation can be obtained from these higher frequency regions. Since the PCTF does not change its form, photographing images at the Scherzer condition will yield higher resolution with higher coherency, however, the transfer of the specimen potential corresponding to contrast enhanced regions is in the oscillations form beyond the first zero. Changes in the defocus will lead to changes in transferred frequencies beyond the first zero and possible extinctions of otherwise transferred information since the oscillations will pass through zero contrast. Interpretation of images under these conditions will, therefore, require accurate measurement of the optical parameters of the microscope and especially accurate measurements of the defocus conditions. It is also important to calculate images under these conditions for comparison with measured images which give the insurance of defocus conditions supposed to be presented.
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Struck, Joachim, Martina Strebelow, Sonja Tietz, Christine Alonso, Nils G. Morgenthaler, Johannes G. van der Hoeven, Peter Pickkers, and Andreas Bergmann. "Method for the Selective Measurement of Amino-Terminal Variants of Procalcitonin." Clinical Chemistry 55, no. 9 (September 1, 2009): 1672–79. http://dx.doi.org/10.1373/clinchem.2008.123018.

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Abstract Background: Procalcitonin (PCT) is an established marker for diagnosing and monitoring bacterial infections. Full-length PCT [116 amino acids that make up procalcitonin (PCT1–116)] can be truncated, leading to des-Ala-Pro-PCT (des-Alanin-Prolin-Procalcitonin; PCT3–116). Current immunoassays for PCT (“total PCT”) use antibodies directed against internal epitopes and are unable to distinguish amino-terminal PCT variants. Here we describe the development of monoclonal antibodies recognizing the amino-termini of PCT1–116 and PCT3–116 and their use in the selective measurement of these PCT species. Methods: With newly developed monoclonal antibodies against the amino-termini of PCT1–116 and PCT3–116, and an antibody against the katacalcin moiety of PCT, we developed and characterized immunoluminometric assays for the 2 PCT peptides. We comparatively assessed the kinetics of PCT variants in a human endotoxemia model. Results: Monoclonal antibodies against the amino-termini of PCT1–116 and PCT3–116 showed <1% cross-reactivity with other PCT-related peptides. The sandwich assays for PCT1–116 and PCT3–116 had functional assay sensitivities of 5 and 1.2 pmol/L, respectively, and exhibited recoveries within 20% of expected values. Plasma PCT1–116 was stable for 6 h at 22 °C and 24 h at 4 °C, and PCT3–116 was stable for at least 24 h at both temperatures. During experimental endotoxemia in healthy people, both PCT1–116 and PCT3–116 increased early in parallel with total PCT, but further increases in PCT1–116 were significantly slower than for PCT3–116 (P = 0.0049) and total PCT (P = 0.0024). Conclusions: The new assays selectively measure PCT1–116 and PCT3–116. Both PCT species increase early during endotoxemia but differ in their kinetics thereafter. The selective measurement of PCT species with different in vivo kinetics may be useful in improving PCT-guided therapies.
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Dissertations / Theses on the topic "PcTF"

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Duclot, Florian. "Rôle de l'acétyltransférase PCAF dans la plasticité cérébrale physiologique et pathologique : analyse de souris PCAF knock-out." Montpellier 2, 2009. http://www.theses.fr/2009MON20244.

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Cautain, Satia. "Etude des mécanismes d'usure en oxygène liquide." Thesis, Châtenay-Malabry, Ecole centrale de Paris, 2014. http://www.theses.fr/2014ECAP0012/document.

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L’oxygène liquide est utilisé principalement dans le domaine de la propulsion spatiale et la connaissance des mécanismes d’usure dans cet environnement est donc indispensable pour le développement des différents moteurs. Ce domaine est mal connu car l’oxygène liquide est un des rares fluides à associer trois propriétés spécifiques pouvant influencer les mécanismes du contact. Ces trois propriétés tribologiques spécifiques sont l’état liquide, la réactivité et la température cryogénique. Une campagne d’essais a été réalisée dans le cadre du projet européen In Space Propulsion-1 (ISP-1) afin d’identifier l’influence de chacune de ces propriétés sur un contact PCTFE/métal. Plusieurs comportements ont ainsi été explicités. D’abord, la présence de lubrification limite a été mise en évidence dans le cas d’un contact en azote liquide. Ensuite,la rugosité de la piste s’est révélé un paramètre fortement influent sur l’usure, les frottements ainsi que sur la formation d’un film de transfert de PCTFE sur le disque. Ce transfert de PCTFE a une grande influence sur le contact. Son épaisseur ainsi que sa régularité influencent directement les mécanismes du contact et plus particulièrement l’usure. Enfin, ces films de transfert se forment rapidement et leur épaisseur augmente avec la distance de glissement, changeant ainsi la vitesse d’usure. Tous ces mécanismes sont très dépendants de la température de surface au niveau du contact qui peut modifier les paramètres des matériaux. L’étude a donc été complétée en comparant une évaluation théorique de la température de surface avec une extrapolation de cette même température à partir des données mesurées dans le pion pendant la réalisation des essais
Liquid oxygen is mainly used for space propulsion. The knowledge of the wear mechanisms in this environment is therefore essential for the development of the engines. Wear mechanisms in liquid oxygen are not well known because liquid oxygen is one of the few fluids combining three tribological properties that can influence contact mechanisms. These three specific tribological properties are the liquid state, the reactivity and the cryogenic temperature. A test campaign was performed in the frame of the European project In Space Propulsion-1 (ISP-1) to identify the influence of each one of these properties on the PCTFE/metal contact. Several behaviors have been explained. First, boundary lubrication has been demonstrated for contactin liquid nitrogen. Then, we confirmed that disk roughness was greatly affecting wear, friction and PCTFE transfer film formation on the disk. This PCTFE transfer film has a great influence on the contact properties. Its thickness and its regularity directly influence contact mechanisms, especially wear. Finally, the transfer film is easily formed and the thickness increases with the sliding distance, thereby changing the wear rate. All these mechanisms are highly dependent on the surface temperature at the contact interface, which can modify the materials parameters.The study was completed by comparing a theoretical evaluation of the surface temperature with an extrapolation of this same temperature from the measured data in the pin during the experiments
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Yang, Yun. "Temperature dependent PCDD/PCDF product distributions from phenols." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/20182.

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Mateo, González Francesca. "Regulació del complex ciclina A-CDK2 per l'acetilasa PCAF." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/914.

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Els complexes ciclina-CDK són elements clau perquè el cicle cel·lular es doni de manera ordenada. Estan regulats a diferents nivells ja que les seves funcions són essencials per a la correcta progressió del cicle. El primer nivell de regulació és la interacció entre la ciclina i la CDK. En segon lloc, aquestes proteïnes poden experimentar fosforilacions i defosforilacions activadores i inhibidores. En tercer lloc, aquests complexes poden ser inhibits per la interacció amb CKIs (CDK Inhibitors). Finalment, la localització subcel·lular també és una manera de regular l'activitat d'aquests complexes, ja que només són actius al nucli de la cèl·lula.

En aquest treball presentem un nou mecanisme de regulació dels complexes ciclina-CDK. Concretament hem observat que els membres del complex ciclina A-CDK2 interaccionen amb l'acetilasa PCAF. Aquesta proteïna ha estat generalment considerada com a un co-activador transcripcional gràcies a la seva capacitat d'acetilar histones i activar la transcripció gènica. Tanmateix, també s'ha vist que és capaç d'acetilar proteïnes no-histones com ara p53 o MyoD, i com a conseqüència està implicada en altres funcions cel·lulars com la diferenciació o la resposta a dany al DNA. L'acetilasa PCAF s'uneix al complex ciclina A-CDK2 tot inhibint la seva activitat quinasa. A més, acetila la ciclina A, cosa que comporta la seva degradació pel sistema ubiquitina-proteasoma. PCAF també acetila CDK2 a la lisina 33, la qual es troba molt conservada a la família de les CDKs, ja que és un aminoàcid crucial per a la interacció amb l'ATP. L'acetilació de CDK2 a la lisina 33 comporta la inhibició de la seva activitat quinasa i la seva separació de la ciclina A.

En conclusió, els resultats d'aquesta tesi aporten un nou nivell de regulació dels complexes ciclina-CDK desconegut fins ara, i que cal tenir en compte com a possible mecanisme d'acció dels fàrmacs basats en compostos inhibidors de deacetilases els quals, d'altra banda, estan donant bons resultats en el tractament de malalties hematològiques i tumors sòlids.
"REGULATION OF CYCLIN A-CDK2 COMPLEX BY ACETYLATION"

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Cell cycle proteins are regulated in different ways, being phosphorylation one of the most important and more studied mechanisms of regulation. On the other hand, acetylation is another kind of post-translational modification that was discovered in histones and initially it was associated with transcriptionally active chromatin. However, different studies indicate that acetylation can also play a role in the regulation of non-histone proteins and it has been linked to oncogenesis and cardiovascular and neurodegenerative diseases.

In this work we report that cyclin A/cdk2 complex, which is crucial for cell cycle progression during S phase, is acetylated by the acetyltransferase P/CAF. Cyclin A directly interacts with P/CAF and is acetylated at lysines 54, 68, 95 and 112. Maximal acetylation occurs simultaneously to ubiquitylation at mitosis, indicating a role of acetylation on cyclin A stability. A non-acetylatable mutant in which these lysines were substituted by arginines (cycA 4R) cannot be ubiquitylated, is more stable than cycA wild-type and arrests cell cycle at mitosis.

Increased expression of cyclin A has been detected in many types of cancers and it has a prognostic value to predict survival or early relapse. Our results indicate that acetylation is able to cause a decrease in the levels of cyclin A, suggesting that treatment with HDAC inhibitors (which potentiate acetylation in the cell) could be considered to treat this kind of tumors.
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Pucella, Riccardo R. "Investigations on relative definability in PCF." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24036.

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The focus of this thesis is the study of relative definability of first-order boolean functions with respect to the language PCF, a paradigmatic typed, higher-order language based on the simply-typed $ lambda$-calculus. The basic core language is sequential. We study the effect of adding construct that embody various notions of parallel execution. The resulting set of equivalence classes with respect to relative definability forms a supsemilattice analoguous to the lattice of degrees in recursion theory. Recent results of Bucciarelli show that the lattice of degrees of parallelism has both infinite chains and infinite antichains. By considering a very simple subset of Sieber's sequentiality relations, we identify levels in the lattice and derive inexpressibility results concerning functions on different levels. This allows us to explore further the structure of the lattice of degrees of parallelism and show the existence of new infinite hierarchies. We also identify four subsemilattices of this structure, all characterized by a simple property.
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Flynn, Kimberly C. Grassco Colleen E. Boorom Eric W. "Paperless Contract Folder's (PCF) DoD 5015.2 certification." Monterey, Calif. : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/JAP/2010/Jun/10Jun%5FFlynn%5FJAP.pdf.

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"Submitted in partial fulfillment of the requirements for the degree of Master of Contract Management from the Naval Postgraduate School, June 2010."
Advisor(s): Doelling, Michael C. ; Brinkley, Douglas E. "June 2010." "Joint applied project"--Cover. Joint authors: .Grasso, Colleen E. ; Boorom, Eric W. Description based on title screen as viewed on July 14, 2010. Author(s) subject terms: Paperless Contract Folder's (PCF) DoD 5015.2 certification Includes bibliographical references (p. 97). Also available in print.
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Flynn, Kimberly C., Eric W. Boorom, and Colleen E. Grasso. "Paperless Contract Folder's (PCF) DoD 5015.2 certification." Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/10522.

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Joint Applied Project
The objective of this project is to conduct an analysis of the CECOM Contracting Center's Paperless Contracting Folder program in regards to maintaining its DoD 5015.2 certification. The desired outcomes will be the creation of a File Plan and User Guide to assist with DoD 5015.2 certification.
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Da, Silva Pereira Luis Miguel. "Combinatorics of Singular Cardinals and PCF structures." Paris 7, 2007. http://www.theses.fr/2007PA077100.

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Ce travail est centré sur la théorie PCF de Shelah. Nous étudions la connexion entre la topologie des espaces PCF et les notions standard de la théorie PCF. Nous démontrons une généralisation du résultat qui dit que les espaces PCF séparables sont séquentiels et nous obtenons comme corollaire qu'il existe beaucoup de suites qui ont une vrai cofmalité modulo l'idéal des ensembles finis. Nous démontrons que ce corollaire est optimal. Nous donnons aussi une démonstration topologique d'estimatives cardinales obtenues précédemment par l'utilisation de la norme de Galvin-Hajnal. Nous étudions une conséquence de la négation de la conjecture PCF de Shelah appelé la Propriété des Ensembles Livres Approximables (PELA). Nous notons que la PELA est incompatible avec l'existence d'échelles continus en forme d'arbre et nous prouvons la consistance de ces échelles avec l'existence des plus grands des grands cardinaux établissant ainsi que la PELA n'est pas impliqué par les grands cardinaux. Nous étudions l'existence d'échelles continus en forme d'arbre et la négation de la PELA en plusieurs extensions de Prikry de l'univers
This work is centered on Shelah's PCF theory. We study the connection between the topology of PCF spaces and standard PCF theory notions. We prove a generalization of the result that says that separable PCF spaces are sequential and obtain as a corollary that there exist many sequences that have true cofinality modulo the ideal of finite sets. We prove that this corollary is optimal. We also give a topological proof of cardinal estimates previously obtained through the use of the Galvin-Hajnal norm. We study a consequence of the negation of Shelah's PCF conjecture called the Approachable Free Subset Property (AFSP). We note that AFSP is incompatible with the existence of tree-like continuous scales and prove the consistency of these scales with the largest large cardinal axioms thus establishing that AFSP is not implied by large cardinals. We study the existence of tree-like continuous scales and the negation of AFSP in several Prikry extensions of the universe
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Perearnau, Garcia Anna. "lmplicacló de p27 i PCAF en la regulació de la transcripció." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/291434.

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En el nostre grup s’ha demostrat la interacció directa entre l’inhibidor de ciclines-CDKs p27 i l’acetiltransferasa PCAF. Aquesta interacció es produeix entre el domini HAT de PCAF i la regió que compren els aminoàcids 91-120 de p27. Aquesta regió conté un PRD (Proline Rich Domain, 91-96aa), un domini característic d’interacció entre proteïnes. En aquest treball hem comprobat que PCAF acetila la lisina en posició 100 de p27 in vivo. L’acetilació de p27 afecta la seva estabilitat, afavorint-ne la seva trasnlocació del nucli al citoplasma, al inici de la fase G1, on serà degradada (Pérez-Luna et al., 2012). PCAF és un co-activador transcripcional que actúa acetilant histones, factors de trasncripció i altres proteïnes. Per altra banda, recentment s’ha descrit que p27 actúa com a regulador transcripcional, bàsicament com a repressor transcripcional de la transcripció de determinats gens diana. Així doncs, com PCAF acetila p27, en aquest treball ens hem centrat en confirmar la col·laboració de p27 i PCAF en la regulació transcripcional dels seus gens diana. Per aconseguir aquest objectiu hem identificat els programes transcripcionals regulats per p27 i PCAF en cèl·lules humanes de càncer de còlon (HCT116), mitjançant experiments de ChIP-seq. Determinem que p27 i PCAF s’uneixen a regions diferents de la cromatina en els seus gens diana. Un cop identificats els gens diana comuns de p27 i PCAF, s’ha analitzat l’expressió de 14 d’aquests gens i hem pogut concloure que p27 i PCAF en regulen la seva transcripció de forma antagònica. p27 reprimeix i PCAF activa l’expressió de la majoria dels gens diana analitzats. Aquest efecte és degut a la unió de p27 i PCAF a elements reguladors de la transcripció en la cromatina. Hem descrit que p27 s’uneix a elements amb efecte activador de la transcripció en la cromatina dels seus gens diana, inhibint-los. Per contra, PCAF s’uneix a elements amb efecte silenciador sobre la transcripció del seus gens diana. Finalment hem demostrat la interacció de p27 i PCAF amb els factors de transcripció PAX en cèl·lules HCT116.
Our group has demonstrated the direct interaction between the cyclin-CDK inhibitor p27 and the acetyltransferase PCAF. This interaction occurs between the HAT domain of PCAF and the region comprising aa 91-120 of p27. This region of p27 contains a PRD (Proline Rich Domain, 91-96aa) a characteristic protein interacting domain. In this study we found that PCAF acetylates the lysine at position 100 of p27 in vivo. The acetylation of p27 affects its stability, promoting its translocation from the nucleus to the cytoplasm early in the G1 phase, where it will be degraded (Pérez-Luna et al., 2012). PCAF acts as a transcriptional coactivator by acetylating histones, transcription factors and other proteins. On the other hand, it has been reported that p27 acts as a transcriptional regulator, basically by repressing transcription of certain target genes. Therefore, since PCAF acetylates p27, in this thesis we focus on confirming the collaboration of p27 and PCAF in the transcriptional regulation of their target genes. To pursue this goal we have identified the transcriptional programs regulated by p27 and PCAF in HCT116 cells by ChIP -seq experiments. We found that p27 and PCAF binds to different regions of the chromatin of their target genes. Once the common target genes of p27 and PCAF were identified, their expression was analyzed. We concluded that p27 and PCAF regulate the transcription of their target genes antagonistically. p27 represses and PCAF activates the expression of most of their target genes, due to its binding to transcription regulatory elements in the chromatin. p27 binds to transcription activating elements, thus inhibiting the transcription of the target gene. On the contrary, PCAF binds to transcription silencing elements, thus activating the transcription of the target gene. Finally we demonstrated the interaction of p27 and PCAF with transcription factors PAX in HCT116 cells.
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Silva, Wanderley Pereira da. "Análise da especialização tecnológica do Brasil por meio da verificação de pedidos de patentes pela via PCT entre os anos de 2000 a 2019." Master's thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/21652.

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Mestrado em Economia e Gestão de Ciência, Tecnologia e Inovação
Esta dissertação analisa o perfil tecnológico brasileiro no período de 2000 a 2019. A partir da construção de uma base de dados com solicitações de patentes pela via PCT provenientes do Banco de Dados Estatísticos da Organização Mundial de Propriedade Intelectual – OMPI, propõe-se explicitar as transformações ocorridas na especialização tecnológica do Brasil, bem como revelar sua evolução. Os resultados obtidos são comparados com os pedidos de residentes em Brasil no escritório nacional de patentes o Instituto Brasileiro de Propriedade Industrial – INPI. Interessante observar que muitos campos tecnológicos que apresentam vantagem tecnológica revelada são comuns em ambos escritórios de patentes. Pelo índice de diversificação é possível verificar que, no período analisado, o Brasil conseguiu aumentar o número de campos tecnológicos especializados. Esse avanço foi significativopois permite que o país progrida para novos processos de aprendizagem eacúmulo de novas competências tecnológicas.
This master´s thesis analyzes the Brazilian technological specialization from 2000 to 2019. Based on a database developed by the author with patents applications via PCT from the Statistical Database of the World Intellectual Property Organization– WIPO, the aim is to explain the transformations that occurred in Brazil´s technological specialization, as well as to characterize its evolution. The results obtained are compared with the applications from residents in Brazil at the national patent office the Brazilian Institute of Industrial Property - INPI. It is interesting to note that many technological fields that present revealed technology are common in both patent offices. Through the diversification index, it is possible to verify that, in the analyzed period, Brazil managed to increase the number of specialized technological fields. This advance is significant because it allows the country to progress to new learning processes and the accumulation of new technological skills.
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Books on the topic "PcTF"

1

Organization, World Intellectual Property. PCT applicant's guide. Geneva: World Intellectual Property Organization, 1985.

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Wakeman, Lois. PCTE: The standard for open repositories. New York: Prentice Hall, 1993.

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Association of Public Health Observatories. Developing public health information for PCG/PCTs. London: Public Health Observatories, 2001.

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McDonnell, Jackie. Yogi's PCT handboook: Planning guide. Shawnee Mission, KS: Yogi's Books, 2011.

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1968-, Liaigre Franck, ed. Les listes noires du PCF. Paris: Calmann-Lévy, 2008.

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Photos d'identité: PCF, 70 ans. Paris: Messidor, 1990.

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Shear, Stephen C. The PCT process: By Steve Shear. 3rd ed. [United States]: Silicon Valley Seminars, 2005.

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Nolff, Markus. TRIPS, PCT, and global patent procurement. London: Kluwer Law International, 2001.

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Nolff, Markus. TRIPS, PCT, and global patent procurement. Boston, MA: Kluwer Law International, 2000.

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Samson, Helfgott, Reed T. David 1961-, and American Bar Association. Section of Intellectual Property Law, eds. The practitioner's guide to the PCT. Chicago, Illinois: ABA, Section of Intellectual Property Law, 2013.

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Book chapters on the topic "PcTF"

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, et al. "pCAF." In Encyclopedia of Signaling Molecules, 1348. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101003.

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Gooch, Jan W. "PCTFE." In Encyclopedic Dictionary of Polymers, 521. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8486.

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Bashford, David. "Polychlorotrifluoroethylene (PCTFE)." In Thermoplastics, 247–48. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-1531-2_45.

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Gooch, Jan W. "PCTFE Fluoroplastics." In Encyclopedic Dictionary of Polymers, 521. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8487.

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Steiner, G., and C. Zimmerer. "Polychlorotrifluoroethylene (PCTFE)." In Polymer Solids and Polymer Melts – Definitions and Physical Properties I, 492–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-32072-9_46.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber, et al. "PCT." In Encyclopedia of Molecular Mechanisms of Disease, 1593. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6602.

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Gooch, Jan W. "PCF." In Encyclopedic Dictionary of Polymers, 521. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8483.

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Gooch, Jan W. "PCT." In Encyclopedic Dictionary of Polymers, 521. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8485.

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, et al. "PCAF Lysine Acetyltransferase." In Encyclopedia of Signaling Molecules, 1349–53. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_511.

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You, Linya, Kezhi Yan, and Xiang-Jiao Yang. "PCAF Lysine Acetyltransferase." In Encyclopedia of Signaling Molecules, 3795–803. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_511.

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Conference papers on the topic "PcTF"

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Iyer, Ganesh Neelakanta, Jayakhanna Pasimuthu, and Ramesh Loganathan. "PCTF: An Integrated, Extensible Cloud Test Framework for Testing Cloud Platforms and Applications." In 2013 13th International Conference on Quality Software (QSIC). IEEE, 2013. http://dx.doi.org/10.1109/qsic.2013.65.

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Haghighi, Payam, Prabath Vemulapalli, Prashant Mohan, Jami J. Shah, and Joseph K. Davidson. "Preliminary Investigation on Generating an Explicit GD&T Scheme From a Process Plan." In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-13123.

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Geometric Dimensioning and Tolerancing (GD&T) Standards have established a language for clear and concise specification of dimensional and geometric variations on manufactured parts. The language includes symbols for tolerance type, tolerance value, datum and reference frames, diameter and material condition modifiers and associativity with geometric entities. Designers use the standard to communicate their dimensional specifications to manufacturing and inspection personnel. However, process planners appear to be less formal in how tolerances are represented in process plans. Typically, they are shown only as dimensional plus/minus values. Datum Reference Frames (DRF) and geometric tolerance symbols are absent. It is believed that the latter are implicit in the set-up and fixturing prescribed in the plan. In this paper we explore how one might extract the implicit information systematically. The motivation for this effort is to verify the consistency of manufacturing tolerances with design specs and to be able to use the same tolerance analysis tools used in design. We discuss three research issues: extracting implied DRFs from set-ups and fixtures; converting plus/minus tolerances to appropriate geometric tolerances; and dealing with transient features — which are features that do not exist on the finished part used for GDT specs by the designer. We propose a new data structure, PCTF (process oriented constraint tolerance feature graph) to facilitate mapping between design and manufacturing tolerances.
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Glabowski, Mariusz. "Continuous threshold model for multi-service wireless systems with PCT1 and PCT2 traffic." In 2007 International Symposium on Communications and Information Technologies. IEEE, 2007. http://dx.doi.org/10.1109/iscit.2007.4392057.

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Weiwei, Wang, and Lu Lu. "Analysis on Impact of Fuel Thermal Conductivity Degradation (TCD) on Large Break Loss of Coolant Accidents of CAP1000." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66283.

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Under high burnup conditions, thermal conductivity of fuel pellet degrades, which is referred to as thermal conductivity degradation (TCD). TCD phenomenon influences fuel average temperature and fuel storage energy under steady state condition before loss of coolant accident (LOCA) and further influences peak cladding temperature (PCT) during large break LOCA process. In this study, sensitivity study on double ended guillotine break of cold leg in CAP1000 at different burnup conditions was performed, using large break LOCA analysis code WCOBRA/TRAC and PCTs under different conditions were obtained. The modified NFI (Nuclear Fuels Institute) TCD model was adopted to model fuel conductivity after degradation in analysis and decrease of peaking factors including FQ and FΔh after 30GWD/MTU was also considered. Sensitivity analysis showed that: after considering the influence of TCD and peaking factor burndown, the PCT limiting case did not occur in low burnup range again, but occurred at burup of about 29GWD/MTU. Compared to other burnup points, the first and second peak values of PCT at that burnup point were all at the highest level. Performing of this study could prefer reference for analysis and estimation of large break LOCA of passive nuclear power plants under high burnup conditions.
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Gkoulalas-Divanis, Aris, and Grigorios Loukides. "PCTA." In the 4th International Workshop. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/1971690.1971695.

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Boudier, Gerard, Ferdinando Gallo, Regis Minot, and Ian Thomas. "An overview of PCTE and PCTE+." In the third ACM SIGSOFT/SIGPLAN software engineering symposium. New York, New York, USA: ACM Press, 1988. http://dx.doi.org/10.1145/64135.65026.

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Zhang, Jiawei, and Philip S. Yu. "PCT." In WWW '16: 25th International World Wide Web Conference. Republic and Canton of Geneva, Switzerland: International World Wide Web Conferences Steering Committee, 2016. http://dx.doi.org/10.1145/2872427.2883038.

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Jiang, Chuan, Sanjay Rao, and Mohit Tawarmalani. "PCF." In SIGCOMM '20: Annual conference of the ACM Special Interest Group on Data Communication on the applications, technologies, architectures, and protocols for computer communication. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3387514.3405858.

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D'Innocenzo, Alessandro, Alessandro Abate, and Joost-Pieter Katoen. "Robust PCTL model checking." In the 15th ACM international conference. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2185632.2185673.

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Liao, Jan-Ray, and Shun-Zhi Lee. "Direct PCF." In 2009 IEEE 13th International Symposium on Consumer Electronics. IEEE, 2009. http://dx.doi.org/10.1109/isce.2009.5156838.

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Reports on the topic "PcTF"

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Thoreson, Gregory G. PCF File Format. Office of Scientific and Technical Information (OSTI), August 2017. http://dx.doi.org/10.2172/1378172.

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Thoreson, Gregory. PCF File Format. Office of Scientific and Technical Information (OSTI), May 2019. http://dx.doi.org/10.2172/1762353.

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Lindquist, Timothy E. Assessing PCTE, CORBA and the WWW. Fort Belvoir, VA: Defense Technical Information Center, May 1997. http://dx.doi.org/10.21236/ada333491.

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Maggio, Gian M., David Laney, and Lawrence Larson. BER and Error-Floor Calculation for Multi-Access PCTH. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada414339.

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Herton, Michael J. UT20-PCTE Browser Tool Version Description Document Version 0.1. Fort Belvoir, VA: Defense Technical Information Center, June 1992. http://dx.doi.org/10.21236/ada257429.

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Smith, Robert C., and Michael J. Horton. UT20-Ada PCTE Binding Version Description Document Version 0.1. Fort Belvoir, VA: Defense Technical Information Center, June 1992. http://dx.doi.org/10.21236/ada257430.

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Schenten, Julian. Product Carbon Footprint (PCF) und die Anreizsituation der Akteure in den Wertschöpfungsketten – Ergebnisse einer Befragung von Unternehmensverbänden. Sonderforschungsgruppe Institutionenanalyse, 2013. http://dx.doi.org/10.46850/sofia.9783941627284.

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Wer den Carbon Footprint für ein Produkt (Product Carbon Footprint oder PCF) ermitteln will, benötigt zu allen Abschnitten im Lebensweg des Produkts Daten zum Ausstoß klimarelevanter Gase. Das Unternehmen, das den PCF für eines seiner Erzeugnisse errechnen möchte, ist daher darauf angewiesen, dass unterschiedliche Akteure – entlang des produktspezifischen Lebenswegs, aber auch im eigenen Betrieb oder Konzernverbund – kooperieren. Dieser Beitrag untersucht die Anreiz- und Hemmnissituation von Akteuren in den Wertschöpfungsketten von Produkten. Analysiert werden sowohl der Akteur, der sein Produkt bilanzieren möchte, als auch die vor- und ggf. nachgelagerten Akteure, die zu diesem Zweck ihre Daten übermitteln müssen. Die Haupterkenntnisquelle der Untersuchung speist sich aus empirischen Befunden, die im Rahmen von Interviews gewonnen wurden oder aus den Fallstudien im Projekt „Unternehmensvorteile durch Umweltmanagement entlang der Wertschöpfungskette und durch Verbraucherinformation – Chancen und Rahmenbedingungen für die Bestimmung und die Kommunikation des CO2-Fußabdrucks von Produkten, insbesondere für kleine und mittlere Unternehmen (PCF-KMU)“ stammen. Ziel ist es,- einen wissenschaftlichen Beitrag im Hinblick auf die Anreiz- und Hemmnis-situation von Akteuren bezüglich des PCF zu leisten;- Unternehmen Anhaltspunkte zu liefern, welche Faktoren in Bezug auf die Interessenlagen der anderen Akteure zu berücksichtigen sind, wenn es den PCF für eines seiner Produkte ermitteln möchte;- Handlungsoptionen aufzuzeigen, wie sich der institutionellen Rahmenbedingungen modifizieren ließen, um Hemmnisse hinsichtlich des PCF abzubauen. Abschnitt 3 nimmt eine Präzisierung des Untersuchungsgegenstands vor. Daraufhin erläutert Abschnitt 4 das methodische Vorgehen. Die Anreizanalyse findet sich dann in Abschnitt 5, wobei eine Systematisierung anhand unterschiedlicher Einflussfaktoren auf die Handlungen der Akteure erfolgt, die Abschnitt 6 in einem Fazit zusammenführt. Zuletzt enthält Abschnitt 7 die aus den Befunden abgeleiteten Gestaltungsoptionen.
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Roberson, G. P., H. E. Martz, D. C. Camp, D. J. Decman, and E. M. Johansson. Preliminary A{ampersand}PCT multiple detector design. Office of Scientific and Technical Information (OSTI), June 1997. http://dx.doi.org/10.2172/567997.

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Muller, Isabelle, Ian Pegg, and Rodney Skeen. Long-Term PCT of ILAW Glasses (FY2019). Office of Scientific and Technical Information (OSTI), September 2019. http://dx.doi.org/10.2172/1784548.

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Puggelli, Alberto A., Wenchao Li, Alberto L. Sangiovanni-Vincentelli, and Sanjit A. Seshia. Polynomial-Time Verification of PCTL Properties of MDPs with Convex Uncertainties. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada583813.

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