Academic literature on the topic 'PDCD1 rs11568821'

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Journal articles on the topic "PDCD1 rs11568821"

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Sutherland, Alison, Jocelyn Davies, Catherine J. Owen, et al. "Genomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves’ Disease Susceptibility." Journal of Clinical Endocrinology & Metabolism 92, no. 8 (2007): 3338–41. http://dx.doi.org/10.1210/jc.2007-0173.

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Abstract Context: A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes. Previous investigations have also demonstrated that an intronic polymorphism (termed PD1.3; SNP ID rs11568821) in the programmed cell death (PDCD1) gene was associated with systemic lupus erythematosus and rheumatoid arthritis. Objective: We sought to replicate these genetic associations in Graves’ disease and autoimmune Addi
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Bialkevich, A. G., A. V. Sukalo, I. A. Kazyra, N. V. Nikitchenko, N. V. Savina, and R. I. Goncharova. "POLYMORPHISM OF STAT4, PTPN22, VEGF, TGF-B, PDCD1 AND PD-L1 GENES IN CHILDREN WITH HEREDITARY NEPHRITIS AND POLYCYSTIC KIDNEY DISEASE." Medical Journal, no. 2(75) (2021): 49–55. http://dx.doi.org/10.51922/1818-426x.2021.2.49.

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The study of the molecular and genetic nature of inherited kidney diseases is relevant in modern nephrology. It allows us to establish the etiology, develop new methods of treatment and prevention. The aim of the research was to study the genetic polymorphism of STAT4, PTPN22, VEGF, TGF-B, PDCD1 and PD-L1 in children with hereditary kidney diseases. The study included patients with hereditary nephritis (n = 40), polycystic kidney disease (n = 26) and chil dren without kidney diseases (n = 416). We use a standard method of phenol-chloroform extraction to isolate genomic DNA. Polymorphic variant
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Abo El-khair, S. M., W. Sameer, N. Awadallah, and D. Shaalan. "Programmed cell death 1 gene polymorphism as a possible risk for systemic lupus erythematosus in Egyptian females." Lupus 28, no. 12 (2019): 1427–34. http://dx.doi.org/10.1177/0961203319878493.

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a suggested genetic basis. The newly identified human programmed cell death 1 gene could be associated with SLE susceptibility. We aimed to investigate the association between programmed cell death 1 polymorphism (PD1.3G/A (rs11568821) and PD1.5C/T (rs2227981)) with the risk of SLE in the Egyptian female population. This retrospective case–control study included 150 Egyptian females; 70 patients diagnosed to have SLE and 80 age-matched healthy controls. The two single nucleotide polymorphisms of the pdcd1 gene were gen
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Giannopoulos, Krzysztof, Maciej Grzywnowicz, Lidia Karabon, et al. "In Chronic Lymphocytic Leukemia PD-1 Is Expressed Independently From PDCD1 Gene Polymorphisms and Does Not Influence BCR Signaling." Blood 122, no. 21 (2013): 1625. http://dx.doi.org/10.1182/blood.v122.21.1625.1625.

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Abstract Background The programmed death-1 (PD-1, CD279) is a negative lymphocytic immunoreceptor responsible for peripheral tolerance. Through inhibition of TCR/BCR signaling PD-1 impairs activation and effectors functions of T and B lymphocytes, where it is expressed upon activation. PD-1 was described on exhausted T cells and it is aberrantly expressed in several malignancies, where a PD-1 pathway was related to a potential tumor escape mechanism from the immunosurveillance. Previously, we characterized PD-1 as a novel phenotypic feature of chronic lymphocytic leukemia (CLL) cells. PD-1 was
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Wagner, Marta, Krzysztof Tupikowski, Monika Jasek, et al. "SNP-SNP Interaction in Genes Encoding PD-1/PD-L1 Axis as a Potential Risk Factor for Clear Cell Renal Cell Carcinoma." Cancers 12, no. 12 (2020): 3521. http://dx.doi.org/10.3390/cancers12123521.

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PD-1/PD-L1 axis plays an important role in maintaining homeostasis and prevention from autoimmunity; however, in the tumor microenvironment, PD-1/PD-L1 interaction is responsible for the evasion of immune surveillance by tumor cells. We therefore hypothesized that single nucleotide polymorphisms (SNPs) in genes encoding PD-1 and PD-L1 molecules are associated with the development and outcome of renal cell carcinoma (RCC). Here we genotyped nine polymorphisms: five of PDCD1: rs36084323G>A, rs11568821G>A, rs2227981C>T, rs10204525G>A, rs7421861T>C and four of PD-L1: rs822335C>T,
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Parakh, Sagun, Ashan Musafer, Sabrina Paessler, et al. "PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma." Frontiers in Immunology 12 (June 9, 2021). http://dx.doi.org/10.3389/fimmu.2021.672521.

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A significant number of patients (pts) with metastatic melanoma do not respond to anti-programmed cell death 1 (PD1) therapies. Identifying predictive biomarkers therefore remains an urgent need. We retrospectively analyzed plasma DNA of pts with advanced melanoma treated with PD-1 antibodies, nivolumab or pembrolizumab, for five PD-1 genotype single nucleotide polymorphisms (SNPs): PD1.1 (rs36084323, G>A), PD1.3 (rs11568821, G>A), PD1.5 (rs2227981, C>T) PD1.6 (rs10204225, G>A) and PD1.9 (rs2227982, C>T). Clinico-pathological and treatment parameters were col
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Dissertations / Theses on the topic "PDCD1 rs11568821"

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Gerber, Sebastian [Verfasser], Sabine [Akademischer Betreuer] [Gutachter] Mihm, and Heike [Gutachter] Bickeböller. "Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis: Vergleich der SOFA-Sub-Scores / Sebastian Gerber. Betreuer: Sabine Mihm. Gutachter: Sabine Mihm ; Heike Bickeböller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1105759946/34.

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Gerber, Sebastian. "Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis: Vergleich der SOFA-Sub-Scores." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-878B-B.

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