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Dissertations / Theses on the topic 'PDE2A'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Lobo, Miguel Gonçalo de Oliveira Jones Ferrão. "Role of PDE2A in cAMP/PKA signaling compartmentalization." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e647c600-48e4-4222-85e7-019f91745608.

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<b>Background and Aims :</b> cAMP/PKA signaling is compartmentalized within the cell, with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), are key regulators of this process. They are situated in specific subcellular domains within which they control local cAMP levels. Several components of the cAMP/PKA cascade have been identified in different mitochondrial compartments, including isoform 2 of PDE2A and multiple A-kinase anchoring proteins, suggesting the presence of multiple cAMP/PKA signali

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2

Delhaye, Sébastien. "Rôle de la phosphodiestérase 2A dans la physiopathologie du syndrome de l’X fragile." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6014.

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Le Syndrome de l’X Fragile (SXF) est la forme la plus fréquente de déficience intellectuelle héréditaire. Le phénotype des patients SXF est complexe. En effet, ils présentent aussi des traits autistiques, de l’hyperactivité et un déficit de l’attention. Au niveau du cerveau, le phénotype majeur est la présence d’épines dendritiques plus nombreuses, plus longues et plus fines. Ces anomalies morphologiques sont associées à des formes altérées de plasticité synaptique chez le modèle murin de SXF, la souris Fmr1-KO. Le SXF est causé par l’expansion (plus de 200 fois) du triplet nucléotidique CGG d

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3

Law, Robert. "PDE3A signalling in blood platelets." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13761.

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Cyclic 3’, 5’ adenosine monophosphate (cAMP) signalling downstream of prostacyclin (PGI₂) is a key inhibitory pathway in blood platelets. This pathway is dynamically regulated by phosphodiesterase 3A (PDE3A), which hydrolyses cAMP into metabolically inactive AMP. Although PDE3A is an established drug target in anti-platelet therapies, the molecular mechanisms that underlie its function in platelets remain unclear. Therefore, the major aim of this study was to further explore PDE3A signalling in human platelets. Using a combination of cell fractionation and immunoblotting we identified two PDE3

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4

Wilson, Moira Ann. "Characterisation and analysis of PDE4A phosphodiesterase isoforms." Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307182.

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5

Johnston, Lee Ann. "The investigation of two novel PDE4A enzymes." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400759.

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6

Livie, Craig. "Determining the role of PDE2 within the mitochondria." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6683/.

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3’,5’-cyclic adenosine monophosphate (cAMP) is a near ubiquitous second messenger responsible for the regulation of a myriad of physiological processes. It is produced by the adenylyl cyclases (AC) and degraded by phosphodiesterases (PDEs). The primary effector of cAMP is protein kinase A (PKA). In order to overcome cross-contamination of separate cAMP-mediated processes within the same cell strict spatiotemporal control is required. Compartmentalisation sculpts cAMP gradients allowing targeted cAMP/PKA action with the cell. This is achieved by the tethering of unique isoforms of AC, PKA and P

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7

Begg, Fiona A. "Cloning and biochemical characterisation of two novel PDE4A cAMP phosphodiesterases." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394925.

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8

Sekharan, Monica R. "Structural studies of the cGMP-binding GAF domain of PDE5A /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.

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9

Ercu, Maria [Verfasser]. "Molecular mechanisms underlying PDE3A-caused hypertension with brachydactyly (HTNB) / Maria Ercu." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1222513862/34.

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10

Lounas, Amel. "Fonction et localisation de la PDE8A dans les cellules ovariennes porcines et son implication dans la stéroïdogenèse." Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27731.

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Les nucléotides cycliques sont des seconds messagers intracellulaires possédant une grande importance dans la signalisation cellulaire du follicule ovarien. Les niveaux intracellulaires en nucléotides cycliques tel que l'adénosine monophosphate cyclique (AMPc) dépendent de leur synthèse, assurée par l'adenylyl-cyclase (AC) ainsi que leur dégradation par les phosphodiéstérases (PDE). Ces dernières appartiennent à la superfamille des métalophosphohydrolases, elles hydrolysent le groupement phosphate en 3' des nucléotides cycliques pour produire un nucléotide 5' phosphate. Dans les cellules ovari

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11

Jiao, Kangwei [Verfasser], and Marius [Akademischer Betreuer] Ueffing. "Evaluation of Neuroprotective Interventions in Different Pde6a Mutant Animal Models for Retinitis Pigmentosa / Kangwei Jiao ; Betreuer: Marius Ueffing." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197134891/34.

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12

Das, Soumyaparna [Verfasser]. "Towards new treatments for hereditary photoreceptor degeneration : Pharmacological and genetic approaches to restore Ca2+ homeostasis and Pde6a function / Soumyaparna Das." Tübingen : Universitätsbibliothek Tübingen, 2022. http://d-nb.info/1234450895/34.

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13

Ruivo, António Filipe de Matos. "Aplicabilidade do modelo de regulação económica vigente na Colômbia para o setor dos serviços de águas ao contexto português." Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/7445.

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Mestrado em Finanças<br>Os serviços públicos de abastecimento de água para consumo humano e saneamento de águas residuais, designados de serviços de águas, sendo prestados por entidades que operam em regime de monopólio natural, e nesta medida, regulados na maioria dos países, são o objeto de estudo neste trabalho. Coloca-se a questão de como podem estes serviços, de interesse económico geral, e recentemente reconhecidos pela ONU como direitos humanos, ser universalmente prestados com qualidade, continuidade e a preços acessíveis, sem que as eventuais ineficiências das entidades que os prestam

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14

Bahn, Yong-Sun. "The role of the cyclic AMP-signaling pathway in morphogenic transitions, resistance to stresses, and virulence of Candida albicans." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054647894.

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15

Selke, Kristin [Verfasser], André [Akademischer Betreuer] Bleich, and Inga [Akademischer Betreuer] Brüsch. "Charakterisierung der Kandidatengene Bcl2l15, Slc30a7, Pde5a und Ifi44 für chronisch entzündliche Darmerkrankungen im Tiermodell der Interleukin-10-defizienten Maus / Kristin Selke ; André Bleich, Inga Brüsch." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2021. http://d-nb.info/123768479X/34.

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16

Mo, Weilan. "Human heart β-adrenoceptors, arrhythmias and control by phosphodiesterases". Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/125160/1/Weilan%20Mo%20Thesis.pdf.

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Heart failure is a global epidemic. 50% of patients die within 5 years of diagnosis and 30–50% will be of sudden death due to an arrhythmia. New medicines for heart failure are urgently required. This thesis used explanted hearts from patients with heart failure undergoing heart transplantation to investigate the cause of dangerous ventricular arrhythmias. It was found that both noradrenaline and adrenaline through activation of β1- and β2-adrenoceptors caused arrhythmias which could be controlled by enzymes called phosphodiesterases. These enzymes provide a novel target for future medicines t

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17

Hwang, Yueh-Fei, and 黃月妃. "Miture Design Approach to PEA-PDEA-PTEA Ternary Polyol-Based Waterborne Polyurethane." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/18712634864229720547.

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18

Yu, Yu Tzu, and 尤鈺慈. "The Role of High Affinity Phosphodiesterase PDE2 in Mitochondria of Senescent Yeast Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/67669496516808463452.

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碩士<br>國立清華大學<br>生物科技研究所<br>103<br>Mitochondria are dynamic organelles that continuously undergo fusion and fission. Mitochondrial dynamics is important for maintaining mitochondrial integrity and cellular function. Aging is a degenerative process that exhibit physiological and mitochondrial dysfunction. Previous studies of our lab revealed mitochondrial fragmentation was present in senescent yeast cells. Resveratrol, a polyphenol mitigated mitochondrial fragmentation and superoxide level. In addition, resveratrol elevated membrane potential in the senescent yeast cells. However, the mechanism

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19

Po-Hsuan and 陳博玄. "Tongkat Ali (Eurycoma longifolia) decrease the PDE5A gene expression and enhance the NO and cGMP concentration of the plasma." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/48108866942795387684.

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碩士<br>中山醫學大學<br>醫學研究所<br>97<br>Eurycoma longifolia (Tongkat Ali) is a plant with folk medicine in Indonesia, Malaysia, Thailand and Vietnam. The residences in Malaysia usually treat it as “ginseng of Malaysia”, and think it possesses multiple medical functions such as anti-hypertension and appetite stimulation. The purpose of this project was to examine the effect of E. longifolia extract on plasma NO and cGMP concentration in mice. Viagra was also used for comparison. Mice were treated by E. longifolia, Viagra, L-Arginine, Tongkat Ali plus ginseng, Dioscorea for 2 and 4 weeks. Plasma

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20

Lämmle, Simon. "Die Rolle der Phosphodiesterase 2 im Herzen." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-994E-0.

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Herzinsuffizienz ist ein weltweites Gesundheitsproblem mit hoher Morbidität und Mortalität und immer noch schlechter Prognose. Ein charakteristisches Merkmal der molekularen und damit verbundenen strukturellen Veränderungen, die der terminalen Insuffizienz vorangehen ist die durch Desensitivierungsmechanismen vermittelte Abnahme des beta-adrenergen (β-AR) Signalmoleküls zyklisches Adenosinmonophosphat (cAMP) auf der einen Seite und der gleichzeitigen Zunahme des von natriuretischen Peptiden (NP) und Stickstoffmonoxid (NO) generierten zyklischen Guanosinmonophosphat (cGMP) auf der anderen Seite

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21

Rood, Keith L. "Novel Adaptor-Dependent Domains Promote Processive Degradation by ClpXP." 2011. https://scholarworks.umass.edu/theses/713.

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Protein degradation by ATP dependent proteases is a universally conserved process. Recognition of substrates by such proteases commonly occurs via direct interaction or with the aid of a regulatory adaptor protein. An example of this regulation is found in Caulobacter crescentus, where key regulatory proteins are proteolysed in a cell-cycle dependent fashion. Substrates include essential transcription factors, structural proteins, and second messenger metabolism components. In this study, we explore sequence and structural requirements for regulated adaptor mediated degradation of PdeA, an imp

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22

Emons, Julius. "Rolle der Phosphodiesterase 2 in der menschlichen und experimentellen Herzinsuffizienz." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F03-1.

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23

Santos, João Filipe Delgado dos. "Regulation of CFTR trafficking and membrane anchoring : new insights into cAMP signalling." Doctoral thesis, 2019. http://hdl.handle.net/10451/42281.

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Cystic Fibrosis (CF) is the most common lethal autosomic recessive disorder among Caucasian population. It is caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein, a cAMP-regulated chloride channel expressed at the apical surface of epithelial cells. The most common CF-causing mutation is a deletion of phenylalanine 508 (F508del, present in 85% of CF patients) and leads to CFTR misfolding which is recognized by the endoplasmic reticulum (ER) quality control (ERQC) resulting in ER retention and degradation. Regulation of CFTR at the pl

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24

Perera, Ruwan K. "Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-9936-4.

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